Performance Comparison between SemiAutomated and Manual Cell Counting for Animal Cell Culture
S. Uhlendorff, U. Odefey, B. Frahm, M. Pein-Hackelbusch, Chemie Ingenieur Technik (2025).

Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis
S. Uhlendorff, T. Burankova, K. Dahlmann, B. Frahm, M. Pein-Hackelbusch, Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, 2025.

Mycelium-based materials from residues of the regional wood industry
L. Reinhardt, V. Gassenmeier, S. Feldt, S. Plate, M. Tremmel, B. Frahm, M. Stosch, Mycelium-Based Materials from Residues of the Regional Wood Industry, n.d.

Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie
J. Segermann, M. Luttmann, A. Blome, S. Feldt, S. Sivanesan, C.-A. Holst, V. Lohweg, B. Frahm, U. Müller, Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie, 2024.

Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen
M. Luttmann, A. Blome, J. Segermann, M. Jekle, B. Frahm, U. Müller, Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen, 2024.

Investigation of microbial spoilage in vegan foods
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Investigation of Microbial Spoilage in Vegan Foods, 2024.

Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-situ Monitoring of Hybridoma Cell Culture
V. Gassenmeier, G. Campolongo, B. Frahm, Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-Situ Monitoring of Hybridoma Cell Culture, 2024.

Process optimization in baked goods production using inline sensors and objective product evaluation
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process Optimization in Baked Goods Production Using Inline Sensors and Objective Product Evaluation, 2024.

Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters
S. Ramm, U. Odefey, B. Frahm, M. Pein-Hackelbusch, (2024).

Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 96 (2024) 528–534.

Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung
A. Blome, M. Luttmann, M. Jekle, B. Frahm, U. Müller, Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung, 2023.

Vorstellung des Projektes eTeig 4.0c - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Vorstellung des Projektes eTeig 4.0“- Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung, 2023.

Real-time Monitoring of DCO2 in addition to DO
V. Gassenmeier, G. Campolongo, B. Frahm, Real-Time Monitoring of DCO2 in Addition to DO, n.d.

A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, DECHEMA e.V., n.d.

View on a mechanistic model of Chlorella vulgaris in shake flasks
V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks, n.d.

Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture
T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, DECHEMA e.V., 2023.

Microbial spoilage in vegan foods
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial Spoilage in Vegan Foods, Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draeenka Komes, Sanja Vidadek Filipec and Bojana Voudko, 2023.

Validation and Uncertainty Assessment of a SoftwareIntegrated Workflow for pH Calculations
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 95 (2023) 1960–1969.

Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression 
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d.

A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, 2023.

Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.

Vorstellung des Projektes eTeig 4.0c - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Vorstellung des Projektes eTeig 4.0“- Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung, 2023.

Teig 4.0 - Promotionsthemen
M. Luttmann, A. Blome, M. Jekle, B. Frahm, U. Müller, Teig 4.0 - Promotionsthemen, 2023.

Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Processes 10 (2022).

A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, n.d.

Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology
V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Current Research in Biotechnology 4 (2022) 102–119.

View on a mechanistic model of Chlorella vulgaris in incubated shake flasks
F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, Bioprocess and Biosystems Engineering 45 (2022) 15–30.

Real-time Monitoring of DCO2 in addition to DO
V. Gassenmeier, B. Frahm, Real-Time Monitoring of DCO2 in Addition to DO, assets-labs, 2022.

Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022, pp. 21–48.

Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products, Versuchsanstalt der Hefeindustrie e.V., 2022.

Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products, 2022.

Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, 2022.

A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion
T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion, n.d.

Microbial spoilage in vegan foods
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial Spoilage in Vegan Foods, 2022.

Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Processes 9 (2021).

Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction
T. Hernández Rodriguez, B. Frahm, Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction, 2021.

Model-assisted Design of Experiments - Concept, Software and Applications
A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-Assisted Design of Experiments - Concept, Software and Applications, 2021.

Bovine Colostrum for Human Consumption
G. Wirtanen, J. Alarinta, B. Frahm, S. Fasse, in: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy &; Animal Science, 2021.

Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing
S. Fasse, J. Alarinta, B. Frahm, G. Wirtanen, Dairy 2 (2021) 556–575.

Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021, pp. 49–74.

Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Bioprocess and Biosystems Engineering 44 (2021) 793–808.

Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses
A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Bioprocess and Biosystems Engineering 44 (2021) 683–700.

Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung
A. Blome, M. Luttmann, B. Frahm, U. Müller, Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung, 2021.

Digital Seed Train Twins and Statistical Methods
T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021, pp. 97–131.

Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes
J. Möller, T. Hernández Rodríguez, J. Müller, L. Arndt, K.B. Kuchemüller, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Computers &; Chemical Engineering 134 (2020) 1–13.

Design, Optimization and Adaptive Control of Cell Culture Seed Trains
T. Hernández Rodríguez, B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, Springer, Berlin, Heidelberg, New York, 2020, pp. 251–267.

Estimation of Process Model Parameters
S. Deppe, B. Frahm, V.C. Hass, T. Hernández Rodríguez, K.B. Kuchemüller, J. Möller, R. Pörtner, in: R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols, Springer, Berlinf; Heidelbergf; New York, 2020, pp. 213–234.

Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.

Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020.

Integration of prior knowledge and digital tools for uncertainty-based decision support
T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support, 2020.

Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration, Wiley, 2020.

Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, Wiley, 2020.

Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner,  Claus  Weihs, R. Pörtner, B. Frahm, Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, BioMed Central, 2020.

Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration
F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, S. Deppe, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.

Model-assisted Design of Experiments for algae cultivation
S. Deppe, F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, J. Möller, R. Pörtner, A. Moser, V.C. Hass, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2020.

Modeling of microalgae in an air-lift photobioreactor for biomass production
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2020.

Predicting industrialscale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, C. Weihs, R. Pörtner, B. Frahm, Biotechnology and Bioengineering 116 (2019) 2944–2959.

Multivariable control strategy for the photosynthetic cultures of microalgae
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae, IEEE, 2019.

Scale-up of stirred vessels
B. Frahm, Scale-up of Stirred Vessels, 2019.

Workflow for model-assisted design and scale-up of biopharmaceutical production processes
J. Möller, J. Müller, T. Hernández Rodriguez, K.B. Kuchemüller, L. Arndt, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes, 2019.

Model-Assisted Design of Experiments
J. Möller, K.B. Kuchemüller, A. Moser, V.C. Hass, T. Hernández Rodriguez, S. Deppe, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments, 2019.

Novel control strategy for microalgae in photobioreactor
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Novel Control Strategy for Microalgae in Photobioreactor, 2019.

Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.

Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.

Model-Assisted Design of Experiments – Software Toolbox
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, S. Deppe, G.A. Ifrim, A. Moser, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments – Software Toolbox, 2019.

Model-assisted Design of Experiments for algae cultivation
S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K.B. Kuchemüller, R. Pörtner, A. Moser, V.C. Hass, G.A. Ifrim, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2019.

Modeling of microalgae in an air-lift photobioreactor for biomass production
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2019.

Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.

Multivariable control strategy for the photosynthetic cultures of microalgae
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae, 2019.

Model-Assisted Design of Process Strategies for Cell Culture Processes
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, American Pharmaceutical Review 3 (2018) 39–41.

A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization
T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, J. Stettner, A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization, 2018.

Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, BioMed Central, 2018.

Model-Assisted Design of Process Strategies for Cell Culture Processes
R. Pörtner, J. Möller, B. Frahm, V.C. Hass, Model-Assisted Design of Process Strategies for Cell Culture Processes, 2018.

Model-Assisted Design and Optimization of Process Strategies
J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design and Optimization of Process Strategies, 2018.

Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses
T. Hernández Rodriguez, J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018.

Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren
T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.

Model-assisted design and optimization of biotechnological processes
R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, Model-Assisted Design and Optimization of Biotechnological Processes, 2017.

Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren
T. Hernández Rodriguez, K.S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.

Influence of parameter accuracies in cell culture seed train simulations
T. Hernández Rodriguez, K.S. Koopmann, R. Pörtner, B. Frahm, Influence of Parameter Accuracies in Cell Culture Seed Train Simulations, 2017.

Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017.

Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017.

Advanced Process and Control Strategies for Bioreactors
R. Pörtner, O. Platas Barradas, B. Frahm, V.C. Hass, in: Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls, Elsevier, Amsterdam, 2016, pp. 463–493.

DMA Photobioreactor System – Cultivation at low shear stress and optional membrane aeration
U. Beshay, S. Feldt, B. Schwarze, P. Wefing, T. Hahne, J. Moschinski, C. Müller, R. Büker, M. Kramer, H. Brod, B. Frahm, DMA Photobioreactor System – Cultivation at Low Shear Stress and Optional Membrane Aeration, 2016.

A software tool for biopharmaceutical seed train design and optimization
T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2016.

Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies
K.S. Koopmann, T. Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, B. Frahm, Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies, 2016.

Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas-Barradas, R. Pörtner, B. Frahm, Cytotechnology 68 (2015) 1019–1032.

Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, BioMed Central, 2015.

Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas Barradas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale, BioMed Central, 2015.

Seed train design and optimization for animal cell suspension culture
B. Frahm, R. Pörtner, S. Kern, T. Hernández Rodriguez, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015.

Seed train design and optimization for animal cell suspension culture
B. Frahm, T. Hernández Rodriguez, S. Kern, K.S. Koopmann, U. Beshay, O. Platas-Barradas, R. Pörtner, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015.

Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015.

Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale, 2015.

A software tool for biopharmaceutical seed train design and optimization
T. Hernández Rodriguez, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2015.

Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015.

Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale, 2015.

Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags
T. Hahne, B. Schwarze, M. Kramer, B. Frahm, Journal of Algal Biomass Utilization 5 (2014) 66–73.

Beleuchtung von disposable Bioreaktoren
B. Frahm, U. Meier, (2014).

Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche
F. Drews, G. Drews, C. Folz, G. Platz, T. Gassenmeier, M. Kramer, C. Hundeiker, B. Schwarze, B. Frahm, Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche, 2014.

Seed train optimization for suspension cell culture
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, BioMed Central , 2013.

Model-based design of the first steps of a seed train for cell culture processes
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes, BioMed Central, 2013.

Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse, 2013.

Model-based design of the first steps of a seed train for cell culture processes
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes, 2013.

Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags
T. Hahne, B. Schwarze, J. Moschinski, A. Kuttig, M. Kramer, B. Frahm, Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags, 2013.

Seed train optimization for suspension cell culture
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, 2013.

Seed Train Optimization for Cell Culture
B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013, pp. 355–367.

Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA), Springer, Dordrecht, 2012.

Photobioreaktor mit rotatorisch oszillierenden Lichtquellen
H. Brod, B. Frahm, (2012).

Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, Vogel Business Media, 2012.

Optimierung des Seed trains von Suspensions-Zellkulturen
R. Marzougui, R. Pörtner, B. Frahm, Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.

A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, J. Dewulf, H. Van Langenhove, R. Ludwig, Journal of Molecular Catalysis B: Enzymatic 68 (2011) 154–161.

Flüssigkeitsbegaser
H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, J. Seletzky, (2011).

Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, 2011.

Intensified absorption and distillation devices for modular chemical production processes
B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, Czech Society of Chemical Engineering, 2010.

Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen
H. Brod, B. Frahm, J. Kauling, (2010).

Bioreaktor
H. Brod, B. Frahm, M. Jenne, J. Kauling, (2010).

Begasungssystem
B. Frahm, J. Kauling, A. Pütz, M. Schindler, (2010).

Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration
B. Frahm, H. Brod, Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration, 2010.

Intensified absorption and distillation devices for modular chemical production processes
B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, 2010.

Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration
B. Frahm, H. Brod, U. Langer, Cytotechnology 59 (2009) 17–30.

Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen
A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, (2009).

Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, U. Langer, Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA), 2009.

Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, U. Langer, Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA), 2009.

Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor
W. Van Hecke, H. Van Langenhovve, B. Frahm, H. Brod, J. Dewulf, D. Haltrich, R. Ludwig, Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor, 2009.

Pushing the Limits in High-Density Mammalian Cell Fermentation
H. Brod, J. Kauling, B. Frahm, M. Jenne, U. Langer, B. Bödeker, Pushing the Limits in High-Density Mammalian Cell Fermentation, 2008.

High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, M. Burnett, U. Langer, B. Bödeker, High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2008.

High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2008.

Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien
B. Frahm, S. Kirchner, J. Kauling, H. Brod, U. Langer, B. Bödeker, Chemie Ingenieur Technik 79 (2007) 1052–1058.

Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller
R. Pörtner, B. Frahm, P. Lane, A. Munack, K. Kühn, V.C. Hass, Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller, Springer, Dordrecht, 2007.

Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component
H. Brod, B. Frahm, J. Kauling, R. Rose, (2007).

Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen
H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, S. Schmidt, (2007).

Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen
H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.

Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen
H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.

High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)
B. Frahm, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, B. Bödeker, High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2007.

Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode
B. Frahm, P. Lane, A. Munack, R. Pörtner, Chemie Ingenieur Technik 77 (2005) 429–435.

Flexible Fed-Batch Process Control of Animal Cells
B. Frahm, R. Pörtner, Flexible Fed-Batch Process Control of Animal Cells, Springer, Dordrecht, 2005.

Optimisation of time-space-yield for hybridoma fed-batch cultures with an adaptive OLFO-controller
R. Pörtner, B. Frahm, P. Lane, A. Munack, Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive OLFO-Controller, 2005.

Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode
R. Pörtner, B. Frahm, V.C. Hass, P. Lane, A. Munack, Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode, 2005.

Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line
R. Pörtner, J.-O. Schwabe, B. Frahm, Biotechnology and Applied Biochemistry 40 (2004).

Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung
B. Frahm, V.C. Hass, P. Lane, A. Munack, H. Märkl, R. Pörtner, Chemie Ingenieur Technik 75 (2003) 457–460.

Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis
B. Frahm, P. Lane, H. Märkl, R. Pörtner, Bioprocess and Biosystems Engineering 26 (2003) 1–10.

Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen
B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003.

Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control
B. Frahm, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control, Inst. für Bioprozess- und Analysenmesstechnik , Heiligenstadt, 2003.

Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells
K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. Hass, Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, ECC, Granada, 2003.

Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies
B. Frahm, R. Pörtner, Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies, 2003.

Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung
B. Frahm, R. Pörtner, Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung, 2003.

Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung
V.C. Hass, K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung, 2003.

Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies
B. Frahm, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies, 2003.

Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung
R. Pörtner, B. Frahm, P. Lane, V.C. Hass, A. Munack, H. Märkl, Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung, 2003.

CO2-off-gas measurement for animal cell culture processes
B. Frahm, R. Pörtner, CO2-off-Gas Measurement for Animal Cell Culture Processes, 2003.

Flexible fed-batch process control of animal cells
B. Frahm, R. Pörtner, Flexible Fed-Batch Process Control of Animal Cells, 2003.

Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells
K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. Hass, Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, 2003.

Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement
B. Frahm, H.-C. Blank, P. Cornand, W. Oelßner, U. Guth, P. Lane, A. Munack, K. Johannsen, R. Pörtner, Journal of Biotechnology 99 (2002) 133–148.

Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells
B. Frahm, P. Lane, H. Atzert, A. Munack, M. Hoffmann, V.C. Hass, R. Pörtner, Biotechnology Progress 18 (2002) 1095–1103.

Reaktor-Abgasmessungen bei Zellkulturen
B. Frahm, R. Pörtner, BIOforum 4 (2002) 179–180.

Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen
B. Frahm, R. Pörtner, Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen, Kurt-Schwabe-Inst. , Meinsberg , 2002.

Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen
B. Frahm, R. Pörtner, Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen, 2002.

Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells
B. Frahm, R. Pörtner, Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells, 2002.

Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells
B. Frahm, R. Pörtner, Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells, 2002.

Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control
B. Frahm, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control, 2002.

Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells
B. Frahm, H. Atzert, P. Lane, M. Hoffmann, V.C. Hass, A. Munack, R. Pörtner, Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells, Springer, Dordrecht, 2001.

Model-Based Control of Hybridoma Cell Cultures
V.C. Hass, P. Lane, M. Hoffmann, B. Frahm, J.-O. Schwabe, R. Pörtner, A. Munack, Model-Based Control of Hybridoma Cell Cultures, 2001.

Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen
B. Frahm, R. Pörtner, Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen, 2001.

Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen
M. Hoffmann, V.C. Hass, B. Frahm, J.-O. Schwabe, R. Pörtner, P. Lane, A. Munack, Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen, 2001.

Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik
B. Frahm, R. Pörtner, Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik, 2001.

Adaptive modellgestützte Steuerung von Zellkulturprozessen
B. Frahm, H. Atzert, J.-O. Schwabe, P. Lane, A. Munack, M. Hoffmann, V.C. Hass, R. Pörtner, Adaptive Modellgestützte Steuerung von Zellkulturprozessen, 2001.

Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities
P. Lane, B. Frahm, H. Atzert, J.-O. Schwabe, M. Hoffmann, V.C. Hass, R. Pörtner, Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities, 2001.

Development of an automated, model-based, adaptive control for the effective cultivation of hybridoma cells
B. Frahm, H. Atzert, P. Lane, M. Hoffmann, V.C. Hass, A. Munack, R. Pörtner, Development of an Automated, Model-Based, Adaptive Control for the Effective Cultivation of Hybridoma Cells, 2001.

Model-Based Control of Hybridoma Cell Cultures
V.C. Hass, P. Lane, M. Hoffmann, B. Frahm, J.-O. Schwabe, R. Pörtner, A. Munack, Model-Based Control of Hybridoma Cell Cultures, ScienceDirect, Oxford, 2001.

Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren
T. Anderelei, B. Frahm, J. Büchs, Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren, 2000.

Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus
M. Hoffmann, B. Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V.C. Hass, A. Munack, Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus, 2000.