@misc{2909,
  author       = {{Brod, Helmut and Frahm, Björn and Kauling, Jörg}},
  location     = {{Würzburg, Germany}},
  title        = {{{Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen}}},
  year         = {{2007}},
}

@misc{2910,
  author       = {{Brod, Helmut and Frahm, Björn and Kauling, Jörg}},
  location     = {{Osnabrück, Germany}},
  title        = {{{Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen}}},
  year         = {{2007}},
}

@misc{2967,
  author       = {{Frahm, Björn and Kirchner, S. and Rose, R. and Jenne, M. and Kauling, J. and Brod, H. and Jöris, K. and Wischniewski, M. and Langer, U. and Bödeker, B.}},
  location     = {{Leverkusen, Germany}},
  title        = {{{High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)}}},
  year         = {{2007}},
}

@misc{2347,
  author       = {{Frahm, Björn and Lane, Paul and Munack, Axel and Pörtner, Ralf}},
  booktitle    = {{Chemie Ingenieur Technik}},
  issn         = {{1522-2640}},
  number       = {{4}},
  pages        = {{429--435}},
  publisher    = {{WILEY-VCH Verlag}},
  title        = {{{Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode}}},
  doi          = {{10.1002/cite.200407094}},
  volume       = {{77}},
  year         = {{2005}},
}

@misc{2813,
  author       = {{Frahm, Björn and Pörtner, R.}},
  booktitle    = {{Animal Cell Technology Meets Genomics}},
  isbn         = {{1-4020-2791-5}},
  location     = {{Granada}},
  pages        = {{693--695}},
  publisher    = {{Springer}},
  title        = {{{Flexible Fed-Batch Process Control of Animal Cells}}},
  doi          = {{10.1007/1-4020-3103-3_142}},
  volume       = {{vol. 2}},
  year         = {{2005}},
}

@misc{2907,
  author       = {{Pörtner, Ralf and Frahm, Björn and Lane, P. and Munack, A.}},
  location     = {{Harrogate, UK}},
  title        = {{{Optimisation of time-space-yield for hybridoma fed-batch cultures with an adaptive OLFO-controller}}},
  year         = {{2005}},
}

@misc{2908,
  author       = {{Pörtner, R. and Frahm, Björn and Hass, V. C. and Lane, P. and Munack, A.}},
  location     = {{Wiesbaden, Germany}},
  title        = {{{Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode}}},
  year         = {{2005}},
}

@misc{2345,
  author       = {{Pörtner, Ralf and Schwabe, Jan-Oliver and Frahm, Björn}},
  booktitle    = {{Biotechnology and Applied Biochemistry}},
  issn         = {{1470-8744}},
  publisher    = {{Wiley-Blackwell}},
  title        = {{{Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line}}},
  doi          = {{10.1042/ba20030168}},
  volume       = {{40}},
  year         = {{2004}},
}

@misc{7934,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Manchester, UK}},
  title        = {{{Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies}}},
  year         = {{2003}},
}

@misc{2343,
  author       = {{Frahm, Björn and Hass, V. C. and Lane, P. and Munack, A. and Märkl, H. and Pörtner, R.}},
  booktitle    = {{Chemie Ingenieur Technik}},
  issn         = {{1522-2640}},
  number       = {{4}},
  pages        = {{457--460}},
  publisher    = {{WILEY-VCH Verlag}},
  title        = {{{Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung}}},
  doi          = {{10.1002/cite.200390093}},
  volume       = {{75}},
  year         = {{2003}},
}

@misc{2344,
  author       = {{Frahm, Björn and Lane, P. and Märkl, H. and Pörtner, R.}},
  booktitle    = {{Bioprocess and Biosystems Engineering}},
  issn         = {{1615-7591}},
  number       = {{1}},
  pages        = {{1--10}},
  publisher    = {{Springer}},
  title        = {{{Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis}}},
  doi          = {{10.1007/s00449-003-0335-z}},
  volume       = {{26}},
  year         = {{2003}},
}

@phdthesis{2393,
  abstract     = {{Die wirtschaftlich immer mehr an Bedeutung gewinnende Kultivierung tierischer Zelllinien umfasst zahlreiche Anwendungen in der Pharmaherstellung und Medizintechnik. Eine Vielzahl der Produkte (Diagnostika, Impfstoffe, Therapeutika) wird in Fed-Batch-Prozessen hergestellt. Für die verbesserte Steuerung von derartigen Fed-Batch-Prozessen stellt der Autor eine adaptive, modellgestützte Steuerung vor. Anwendungsbeispiele veranschaulichen das Potential und die Flexibilität der Steuerung und ihre Universalität bezüglich verschiedener Kultivierungssysteme und Zelllinien. 

Da auch die gelöst-CO2-Konzentration und die Atmungsaktivität der Zellen zunehmend Bedeutung in der Prozessführung erlangen, stellt dieses Buch weiterhin die entwickelte Erfassung dieser Größen per Abgasanalytik und Modellierung des Kohlendioxidtransfers vor.}},
  author       = {{Frahm, Björn}},
  isbn         = {{ 	978-3-8334-0111-4 }},
  keywords     = {{Tierzelle, Suspensionskultur, Prozesssteuerung}},
  pages        = {{120}},
  publisher    = {{Books on Demand GmbH}},
  title        = {{{Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen}}},
  year         = {{2003}},
}

@misc{2435,
  author       = {{Frahm, Björn and Müller-Landré, B. and Wiggers de Almeida, G. and Singer, M. and Rausch, M. and Lane, P. and Munack, A. and Hass, V. C. and Pörtner, R.}},
  booktitle    = {{Technische Systeme für Biotechnologie und Umwelt}},
  editor       = {{Beckmann, Dieter}},
  isbn         = {{3-00-011287-1}},
  location     = {{Heilbad Heiligenstadt}},
  pages        = {{503--509}},
  publisher    = {{Inst. für Bioprozess- und Analysenmesstechnik }},
  title        = {{{Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control}}},
  year         = {{2003}},
}

@misc{2436,
  author       = {{Kühn, K. and Frahm, Björn and Pörtner, R. and Lane, P. and Munack, A. and Hass, V. C.}},
  booktitle    = {{ ECCE - 4th European Congress of Chemical Engineering}},
  isbn         = {{84-88233-35-3}},
  location     = {{Granada}},
  publisher    = {{ECCE4}},
  title        = {{{Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells}}},
  volume       = {{10}},
  year         = {{2003}},
}

@inproceedings{2901,
  author       = {{Pörtner, R. and Frahm, Björn}},
  location     = {{Manchester, UK}},
  title        = {{{Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies}}},
  year         = {{2003}},
}

@misc{2902,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Göttingen, Germany}},
  title        = {{{Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung}}},
  year         = {{2003}},
}

@misc{2903,
  author       = {{Hass, V. C.  and Kühn, K. and Frahm, Björn and Pörtner, R. and Lane, P. and Munack, A.}},
  location     = {{München}},
  title        = {{{Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung}}},
  year         = {{2003}},
}

@misc{2905,
  author       = {{Frahm, Björn and Lane, P. and Munack, A. and Hass, V. C. and Pörtner, Ralf}},
  location     = {{Frankfurt am Main, Germany}},
  title        = {{{Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies}}},
  year         = {{2003}},
}

@misc{2906,
  author       = {{Pörtner, Ralf and Frahm, Björn and Lane, P. and Hass, V. C. and Munack, A. and Märkl, H.}},
  location     = {{Bad Dürkheim, Germany}},
  title        = {{{Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung}}},
  year         = {{2003}},
}

@misc{2964,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Manchester, UK}},
  title        = {{{CO2-off-gas measurement for animal cell culture processes}}},
  year         = {{2003}},
}

@misc{2965,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Granada, Spain}},
  title        = {{{Flexible fed-batch process control of animal cells}}},
  year         = {{2003}},
}

@misc{2966,
  author       = {{Kühn, K. and Frahm, Björn and Pörtner, Ralf and Lane, P. and Munack, A. and Hass, V. C.}},
  location     = {{Granada, Spain}},
  title        = {{{Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells}}},
  year         = {{2003}},
}

@misc{2340,
  author       = {{Frahm, Björn and Blank, H.-C. and Cornand, P. and Oelßner, W. and Guth, U. and Lane, P. and Munack, A. and Johannsen, K. and Pörtner, R.}},
  booktitle    = {{Journal of Biotechnology}},
  issn         = {{1873-4863 }},
  keywords     = {{Dissolved carbon dioxide, Carbon dioxide production rate, Carbon dioxide transfer rate, Off-gas measurement, Mammalian cell suspension culture}},
  number       = {{2}},
  pages        = {{133--148}},
  publisher    = {{Elsevier}},
  title        = {{{Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement}}},
  doi          = {{https://doi.org/10.1016/S0168-1656(02)00180-3}},
  volume       = {{99}},
  year         = {{2002}},
}

@misc{2341,
  author       = {{Frahm, Björn and Lane, P. and Atzert, H. and Munack, A. and Hoffmann, M. and Hass, V. C. and Pörtner, R.}},
  booktitle    = {{Biotechnology Progress}},
  issn         = {{1520-6033}},
  number       = {{5}},
  pages        = {{1095--1103}},
  publisher    = {{ Wiley }},
  title        = {{{Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells}}},
  doi          = {{10.1021/bp020035y}},
  volume       = {{18}},
  year         = {{2002}},
}

@misc{2342,
  author       = {{Frahm, Björn and Pörtner, R.}},
  booktitle    = {{BIOforum}},
  issn         = {{0940-0079}},
  pages        = {{179--180}},
  publisher    = {{GIT-Verlag}},
  title        = {{{Reaktor-Abgasmessungen bei Zellkulturen}}},
  volume       = {{4}},
  year         = {{2002}},
}

@misc{2431,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  booktitle    = {{Biosystemtechnik: Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung biotechnologischer Prozesse}},
  editor       = {{Kaden , Heiner }},
  isbn         = {{3-00-009026-6}},
  location     = {{Waldheim/Sa. }},
  pages        = {{39--48}},
  publisher    = {{Kurt-Schwabe-Inst. }},
  title        = {{{Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen}}},
  year         = {{2002}},
}

@misc{2897,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Wiesbaden, Germany}},
  title        = {{{Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen}}},
  year         = {{2002}},
}

@misc{2898,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Lonza Biologics, Slough, UK}},
  title        = {{{Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells}}},
  year         = {{2002}},
}

@misc{2899,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Birmingham, UK}},
  title        = {{{Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells}}},
  year         = {{2002}},
}

@misc{2900,
  author       = {{Frahm, Björn and Müller-Landré, B. and Wiggers de Almeida, G. and Singer, M. and Rausch, M. and Lane, P. and Munack, A. and Hass, V. C. and Pörtner, R.}},
  location     = {{Heilbad Heiligenstadt, Germany}},
  title        = {{{Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control}}},
  year         = {{2002}},
}

@misc{7933,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Waldheim, Germany}},
  title        = {{{Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen}}},
  year         = {{2001}},
}

@misc{2427,
  author       = {{Frahm, Björn and Atzert, H. and Lane, P. and Hoffmann, M. and Hass, V. C. and Munack, A. and Pörtner, Ralf}},
  booktitle    = {{Animal Cell Technology: From Target to Market}},
  isbn         = {{9789401038973}},
  pages        = {{446--448}},
  publisher    = {{Springer}},
  title        = {{{Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells}}},
  doi          = {{10.1007/978-94-010-0369-8_107}},
  volume       = {{vol. 1}},
  year         = {{2001}},
}

@misc{2429,
  author       = {{Hass, V. C. and Lane, P. and Hoffmann, M. and Frahm, Björn and Schwabe, J.-O. and Pörtner, R. and Munack, A.}},
  location     = {{Québec City, Québec, Canada}},
  title        = {{{Model-Based Control of Hybridoma Cell Cultures}}},
  year         = {{2001}},
}

@misc{2894,
  author       = {{Hoffmann, M. and Hass, V. C.  and Frahm, Björn and Schwabe, J.-O. and Pörtner, R. and Lane, P. and Munack, A.}},
  location     = {{Leipzig, Germany}},
  title        = {{{Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen}}},
  year         = {{2001}},
}

@misc{2895,
  author       = {{Frahm, Björn and Pörtner, R.}},
  location     = {{Hannover}},
  title        = {{{Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik}}},
  year         = {{2001}},
}

@misc{2960,
  author       = {{Frahm, Björn and Atzert, H. and Schwabe, J.-O. and Lane, P. and Munack, A. and Hoffmann, M. and Hass, V. C. and Pörtner, R.}},
  location     = {{Leipzig, Germany}},
  title        = {{{Adaptive modellgestützte Steuerung von Zellkulturprozessen}}},
  year         = {{2001}},
}

@misc{2961,
  author       = {{Lane, P. and Frahm, Björn and Atzert, H. and Schwabe, J.-O. and Hoffmann, M. and Hass, V. C. and Pörtner, R.}},
  location     = {{Leipzig, Germany}},
  title        = {{{Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities}}},
  year         = {{2001}},
}

@misc{2962,
  author       = {{Frahm, Björn and Atzert, H. and Lane, P. and Hoffmann, M. and Hass, V. C. and Munack, A. and Pörtner, R.}},
  location     = {{Tylösand, Sweden}},
  title        = {{{Development of an automated, model-based, adaptive control for the effective cultivation of hybridoma cells}}},
  year         = {{2001}},
}

@misc{2963,
  author       = {{Hass, V.C. and Lane, P. and Hoffmann, M. and Frahm, Björn and Schwabe, J.-O. and Pörtner, R. and Munack, A.}},
  booktitle    = {{Computer Applications in Biotechnology, 2001: Modelling, Monitoring and Control of Biotechnological Processes}},
  isbn         = {{ 0080436811 }},
  issn         = {{ 1474-6670 }},
  location     = {{Québec City, Québec, Canada}},
  pages        = {{323--329}},
  publisher    = {{ScienceDirect}},
  title        = {{{Model-Based Control of Hybridoma Cell Cultures}}},
  doi          = {{https://doi.org/10.1016/S1474-6670(17)34240-4}},
  volume       = {{34}},
  year         = {{2001}},
}

@misc{2893,
  author       = {{Anderelei, T. and Frahm, Björn and Büchs, J.}},
  location     = {{Bamberg, Germany}},
  title        = {{{Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren}}},
  year         = {{2000}},
}

@misc{2959,
  author       = {{Hoffmann, M. and Frahm, Björn and Schwabe, J.-O. and Lane, P. and Pörtner, R. and Hass, V. C. and Munack, A.}},
  location     = {{Heilbad Heiligenstadt, Germany}},
  title        = {{{Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus}}},
  year         = {{2000}},
}