@misc{2986,
  author       = {{Kern, S. and Platas, O. and Schaletzky, M. and Sandig, V. and Frahm, Björn and Pörtner, R.}},
  location     = {{Hamburg, Germany}},
  title        = {{{Model-based strategy for cell culture seed train layout verified at lab scale}}},
  year         = {{2015}},
}

@misc{2987,
  author       = {{Hernández Rodriguez, Tanja and Pörtner, R. and Frahm, Björn}},
  location     = {{Munic, Germany}},
  title        = {{{A software tool for biopharmaceutical seed train design and optimization}}},
  year         = {{2015}},
}

@misc{2988,
  author       = {{Hernández Rodriguez, Tanja and Pörtner, R. and Frahm, Björn}},
  location     = {{Barcelona, Spain}},
  title        = {{{Considerations for cell passaging in cell culture seed trains}}},
  year         = {{2015}},
}

@misc{2990,
  author       = {{Kern, S. and Platas, O. and Schaletzky, M. and Sandig, V. and Frahm, Björn and Pörtner, R.}},
  location     = {{Barcelona, Spain}},
  title        = {{{Model-based strategy for cell culture seed train layout verified at lab scale}}},
  year         = {{2015}},
}

@misc{2388,
  author       = {{Hahne, T. and Schwarze, B. and Kramer, M. and Frahm, Björn}},
  booktitle    = {{Journal of Algal Biomass Utilization}},
  issn         = {{2229-6905}},
  number       = {{2}},
  pages        = {{66--73}},
  publisher    = {{PHYCO SPECTRUM}},
  title        = {{{Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags}}},
  volume       = {{5}},
  year         = {{2014}},
}

@misc{2878,
  abstract     = {{Ein Bioreaktor mit einem Disposable Bag, der einen von einer Wandung (1) begrenzten Reaktorraum (2) aufweist, ist als Photo-Bioreaktor ausgelegt, bei dem in unmittelbarer Nachbarschaft der Wandung (1) des Disposable Bags Lichtquellen (LED-Streifen 6) angeordnet sind. }},
  author       = {{Frahm, Björn and Meier, Uwe}},
  pages        = {{9}},
  title        = {{{Beleuchtung von disposable Bioreaktoren}}},
  year         = {{2014}},
}

@misc{2984,
  author       = {{Drews, F. and Drews, G. and Folz, C. and Platz, G. and Gassenmeier, Thomas and Kramer, M. and Hundeiker, C. and Schwarze, B. and Frahm, Björn}},
  location     = {{Köthen, Germany}},
  title        = {{{Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche}}},
  year         = {{2014}},
}

@inbook{2394,
  abstract     = {{For the production of biopharmaceuticals a seed train is required to generate an adequate number of cells for inoculation of the production bioreactor. This seed train is time- and cost-intensive but offers potential for optimization. A method and a protocol are described for the seed train mapping, directed modeling without major effort, and its optimization regarding selected optimization criteria such as optimal points in time for cell passaging. Furthermore, the method can also be applied for the set-up of a new seed train, for example for a new cell line. Although the chapter is directed towards suspension cell lines, the method is also generally applicable, e.g. for adherent cell lines.}},
  author       = {{Frahm, Björn}},
  booktitle    = {{Animal Cell Biotechnology}},
  isbn         = {{9781627037327}},
  issn         = {{1064-3745}},
  keywords     = {{Seed train Optimization Modeling Prediction Space-Time-Yield (STY) Systems approach Bioinformatics Computational biotechnology Suspension Production}},
  pages        = {{355--367}},
  publisher    = {{Humana Press}},
  title        = {{{Seed Train Optimization for Cell Culture}}},
  doi          = {{10.1007/978-1-62703-733-4_22}},
  volume       = {{1104}},
  year         = {{2013}},
}

@misc{2817,
  author       = {{Hernández Rodriguez, Tanja and Pörtner, Ralf and Frahm, Björn}},
  booktitle    = {{BMC proceedings / BioMed Central }},
  issn         = {{1753-6561}},
  publisher    = {{BioMed Central }},
  title        = {{{Seed train optimization for suspension cell culture}}},
  doi          = {{10.1186/1753-6561-7-s6-p9}},
  volume       = {{7}},
  year         = {{2013}},
}

@misc{2818,
  author       = {{Kern, Simon and Platas, Oscar and Schaletzky, Martin and Sandig, Volker and Frahm, Björn and Pörtner, Ralf}},
  booktitle    = {{BMC proceedings / BioMed Central }},
  issn         = {{1753-6561}},
  publisher    = {{BioMed Central}},
  title        = {{{Model-based design of the first steps of a seed train for cell culture processes}}},
  doi          = {{10.1186/1753-6561-7-s6-p11}},
  volume       = {{7}},
  year         = {{2013}},
}

@misc{2980,
  author       = {{Kern, S. and Platas, O. and Schaletzky, M. and Sandig, V.  and Frahm, Björn and Pörtner, R.}},
  location     = {{Bad Wildungen, Germany}},
  title        = {{{Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse}}},
  year         = {{2013}},
}

@misc{2981,
  author       = {{Kern, S. and Platas, O. and Schaletzky, M. and Sandig, V.  and Frahm, Björn and Pörtner, R.}},
  location     = {{Lille, France}},
  title        = {{{Model-based design of the first steps of a seed train for cell culture processes}}},
  year         = {{2013}},
}

@misc{2982,
  author       = {{Hahne, T. and Schwarze, B. and Moschinski, J. and Kuttig, A. and Kramer, M. and Frahm, Björn}},
  location     = {{Hamburg, Germany}},
  title        = {{{Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags}}},
  year         = {{2013}},
}

@misc{2983,
  author       = {{Hernández Rodriguez, Tanja and Pörtner, R. and Frahm, Björn}},
  location     = {{Lille, France}},
  title        = {{{Seed train optimization for suspension cell culture}}},
  year         = {{2013}},
}

@misc{2816,
  author       = {{Frahm, Björn and Brod, H.}},
  booktitle    = {{Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009}},
  isbn         = {{978-94-007-0883-9}},
  issn         = {{978-94-007-0884-6}},
  location     = {{ Dublin, Ireland}},
  pages        = {{355--359}},
  publisher    = {{Springer}},
  title        = {{{Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA)}}},
  doi          = {{10.1007/978-94-007-0884-6_56}},
  volume       = {{vol. 5}},
  year         = {{2012}},
}

@misc{2877,
  abstract     = {{Die Erfindung betrifft einen Photobioreaktor mit Belichtung durch rotatorisch oszillierend bewegte Lichtquellen (Lichtleiter, LEDs) sowie optional kombiniert rotatorisch oszillierend bewegte Membranflächen zum Gastransport. Vorteile sind unter anderem ein im zeitlichen Mittel räumlich homogener Lichteintrag, welcher über Intensität und Oszillation an die Kultur und deren Dichte angepasst werden kann, sowie ein scherarmer Leistungseintrag und optional eine scherarme blasenfreie Be- und Entgasung. }},
  author       = {{Brod, Helmut and Frahm, Björn}},
  pages        = {{19}},
  title        = {{{Photobioreaktor mit rotatorisch oszillierenden Lichtquellen}}},
  year         = {{2012}},
}

@misc{2918,
  author       = {{Van Hecke, W. and Haltrich, D. and Frahm, Björn and Brod, H. and Ludwig, R.}},
  booktitle    = {{Achema 2012}},
  location     = {{Frankfurt am Main, Germany}},
  publisher    = {{Vogel Business Media}},
  title        = {{{Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor}}},
  year         = {{2012}},
}

@misc{2973,
  author       = {{Marzougui, R. and Pörtner, R. and Frahm, Björn}},
  location     = {{Freiburg, Germany}},
  title        = {{{Optimierung des Seed trains von Suspensions-Zellkulturen}}},
  year         = {{2012}},
}

@misc{2350,
  author       = {{Van Hecke, Wouter and Haltrich, Dietmar and Frahm, Björn and Brod, Helmut and Dewulf, Jo and Van Langenhove, Herman and Ludwig, Roland}},
  booktitle    = {{Journal of Molecular Catalysis B: Enzymatic}},
  issn         = {{1381-1177}},
  number       = {{2}},
  pages        = {{154--161}},
  publisher    = {{Elsevier}},
  title        = {{{A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor}}},
  doi          = {{10.1016/j.molcatb.2010.10.004}},
  volume       = {{68}},
  year         = {{2011}},
}

@misc{2876,
  abstract     = {{Die Erfindung betrifft einen Begaser zum Eintrag eines Gases oder Gasgemisches in eine Flüssigkeit sowie ein Verfahren zur Begasung von Flüssigkeiten. Der erf?ndungsgemäße Begaser umfasst einen Hohlraum, einen Gaseinlass zum Einleiten eines Gases in den Hohlraum und zwei oder mehr Flächen, die formschlüssig aufeinander gepresst sind oder gepresst werden können, so dass ein durch den Gaseinlass in den Hohlraum gedrücktes Gas durch die zwischen den zusammengepressten Flächen auftretenden Spalten entweicht. }},
  author       = {{Brod, Helmut and Frahm, Björn and Jenne, Marc and Kauling, Jörg and Schmitt, Franz and Seletzky, Juri}},
  pages        = {{32}},
  title        = {{{Flüssigkeitsbegaser}}},
  year         = {{2011}},
}

@misc{2972,
  author       = {{Van Hecke, W. and Haltrich, D. and Frahm, Björn and Brod, H. and Ludwig, R.}},
  location     = {{Berlin, Germany}},
  title        = {{{Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor}}},
  year         = {{2011}},
}

@misc{2815,
  author       = {{Dercks, B. and Frahm, Björn and Grünewald, M. and Kenig, E. and Lautenschleger, A. and Gorak, A. and Schmidt, P.  and Sudhoff, D. and Ressler, S. and Zecirovic, R.}},
  booktitle    = {{Proceedings 19th International Congress of Chemical and Process Engineering}},
  isbn         = {{978-80-02-02250-3}},
  location     = {{Prague, CZ}},
  publisher    = {{Czech Society of Chemical Engineering}},
  title        = {{{Intensified absorption and distillation devices for modular chemical production processes}}},
  year         = {{2010}},
}

@misc{2873,
  abstract     = {{Die Erfindung betrifft ein Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen, insbesondere von Zellkulturen, welche zur Agglomeration bzw. Anhaftung an den Bioreaktor und seine Elemente neigen, oder bei denen Zelldebris oder Substanzen leicht agglomerieren bzw. anhaften.}},
  author       = {{Brod, Helmut and Frahm, Björn and Kauling, Jörg}},
  pages        = {{26}},
  title        = {{{Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen}}},
  year         = {{2010}},
}

@misc{2874,
  abstract     = {{Die Erfindung betrifft einen Bioreaktor, die Verwendung des Bioreaktors zur Kultivierung von Mikroorganismen oder Zellkulturen sowie ein Verfahren zur Kultivierung von Mikroorganismen oder Zellkulturen. }},
  author       = {{Brod, Helmut and Frahm, Björn and Jenne, Marc and Kauling, Jörg}},
  pages        = {{27}},
  title        = {{{Bioreaktor}}},
  year         = {{2010}},
}

@misc{2875,
  abstract     = {{Gegenstand der Erfindung ist ein neuartiges Begasungssystem, das insbesondere aber nicht ausschließlich in der Biotechnologie zur Versorgung von Zellen oder Mikroorganismen mit Sauerstoff einsetzbar ist. Das Begasungssystem umfasst eine Blasensäule und einen Verteiler. In dem Gefäß befindet sich ferner ein flüssiges Medium, das mit Gas versorgt werden soll. Es wird ein Vektor als Transportmittel für das Gas eingesetzt. Das Gas wird in die Blasensäule eingetragen und hier von dem Vektor aufgenommen. Der Vektor wird in Tropfenform über den Verteiler auf die Flüssigkeitsoberfläche aufgetragen, sinkt in dem Medium nach unten und gibt einen Teil des aufgenommenen Gases an das Medium ab. Am Boden des Gefäßes befindet sich eine Sammelvorrichtung, in der die Vektortropfen koaleszieren und wieder in die Blasensäule gelangen. Gegenstand der Erfindung ist weiterhin ein Bioreaktor umfassend das neuartige Begasungssystem. Gegenstand der Erfindung ist ferner ein Verfahren zur Begasung eines flüssigen Mediums, vorzugsweise einer Zellen oder Mikroorganismen enthaltenden wässrigen Suspension. }},
  author       = {{Frahm, Björn and Kauling, Jörg and Pütz, Andre and Schindler, Markus}},
  pages        = {{35}},
  title        = {{{Begasungssystem}}},
  year         = {{2010}},
}

@misc{2892,
  author       = {{Frahm, Björn and Brod, Helmut}},
  location     = {{Boston, USA}},
  title        = {{{Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration}}},
  year         = {{2010}},
}

@misc{2913,
  author       = {{Dercks, B. and Frahm, Björn and Grünewald, M. and Kenig, E. and Lautenschleger, A. and Gorak, A. and Schmidt, P. and Sudhoff, D. and Ressler, S. and Zecirovic, R.}},
  location     = {{Prague, Czech Republic}},
  title        = {{{Intensified absorption and distillation devices for modular chemical production processes}}},
  year         = {{2010}},
}

@misc{2349,
  author       = {{Frahm, Björn and Brod, Helmut and Langer, Uwe}},
  booktitle    = {{Cytotechnology}},
  issn         = {{1573-0778}},
  number       = {{1}},
  pages        = {{17--30}},
  publisher    = {{Springer}},
  title        = {{{Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration}}},
  doi          = {{10.1007/s10616-009-9189-9}},
  volume       = {{59}},
  year         = {{2009}},
}

@misc{2872,
  abstract     = {{Die Erfindung betrifft eine Vorrichtung und ein Verfahren zur Rückhaltung und Rückführung von Zellen in einem kontinuierlich oder absatzweise durchströmten Gefäß. Ferner betrifft die Erfindung ein Verfahren zur Herstellung einer Vorrichtung, mit dem Zellen in einem kontinuierlich oder absatzweise durchströmten Gefäß zurückgehalten und zurückgeführt werden können. }},
  author       = {{Braun, Arndt and Brod, Helmut and Frahm, Björn and Jenne, Marc and Kauling, Jörg and Kirchner, Stephan}},
  pages        = {{35}},
  title        = {{{Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen}}},
  year         = {{2009}},
}

@misc{2912,
  author       = {{Frahm, Björn and Brod, H. and Langer, U.}},
  location     = {{Frankfurt am Main, Germany}},
  title        = {{{Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)}}},
  year         = {{2009}},
}

@misc{2970,
  author       = {{Frahm, Björn and Brod, H. and Langer, U.}},
  location     = {{Dublin, Ireland}},
  title        = {{{Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)}}},
  year         = {{2009}},
}

@misc{2971,
  author       = {{Van Hecke, W. and Van Langenhovve, H. and Frahm, Björn and Brod, H. and Dewulf, J. and Haltrich, D. and Ludwig, R.}},
  location     = {{Krakow, Poland}},
  title        = {{{Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor}}},
  year         = {{2009}},
}

@misc{2911,
  author       = {{Brod, H. and Kauling, J. and Frahm, Björn and Jenne, M. and Langer, U. and Bödeker, B.}},
  location     = {{Leverkusen, Germany}},
  title        = {{{Pushing the Limits in High-Density Mammalian Cell Fermentation}}},
  year         = {{2008}},
}

@misc{2968,
  author       = {{Frahm, Björn and Brod, H. and Burnett, M. and Langer, U. and Bödeker, B.}},
  location     = {{Palladium, Cologne, Germany}},
  title        = {{{High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)}}},
  year         = {{2008}},
}

@misc{2969,
  author       = {{Frahm, Björn and Brod, Helmut}},
  location     = {{Leverkusen, Germany}},
  title        = {{{High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)}}},
  year         = {{2008}},
}

@inproceedings{4037,
  author       = {{Bödeker, A. and Bensmann, H.  and Kutz, Gerd}},
  location     = {{Nürnberg}},
  title        = {{{Qualification of a packaging line for cylindrical containers and blister packs}}},
  year         = {{2007}},
}

@misc{2348,
  author       = {{Frahm, Björn and Kirchner, S. and Kauling, J. and Brod, H. and Langer, U. and Bödeker, B.}},
  booktitle    = {{Chemie Ingenieur Technik}},
  issn         = {{0009-286X}},
  number       = {{7}},
  pages        = {{1052--1058}},
  publisher    = {{WILEY-VCH Verlag}},
  title        = {{{Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien}}},
  doi          = {{10.1002/cite.200700070}},
  volume       = {{79}},
  year         = {{2007}},
}

@misc{2814,
  author       = {{Pörtner, Ralf and Frahm, Björn and Lane, Paul and Munack, Axel and Kühn, Kathrin and Hass, Volker C.}},
  booktitle    = {{Cell Technology for Cell Products}},
  isbn         = {{978-1-402-05475-4}},
  location     = {{Harrogate, UK}},
  pages        = {{497--501}},
  publisher    = {{Springer}},
  title        = {{{Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller}}},
  doi          = {{10.1007/978-1-4020-5476-1_84}},
  volume       = {{vol. 3}},
  year         = {{2007}},
}

@misc{2870,
  abstract     = {{The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude and the equivalent number of revolutions. The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude, the equivalent number of revolutions, acceleration of the membrane surface, the delay of the membrane surface, the interruption of the movement or discontinuity. The course of motion is not restricted to recurring samples. The material transfer is increased by mounting of immovable current interfering elements. The disturb of the current forms by the rotatingly oscillating movement of the membrane surfaces. The supply of the membrane surface is undertaken with the help of flexible hoses or turning seals for the supply and discharge of gas. The membrane surface is used for the production of micro-bubbles or gas bubbles in the liquid. Rotor arms rotate in one of the rotation directions curved around the drive shaft. An independent claim is included for a device for gassing of liquid for cell cultures.  }},
  author       = {{Brod, Helmut and Frahm, Björn and Kauling, Jörg and Rose, Reinhold}},
  title        = {{{Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component}}},
  year         = {{2007}},
}

@misc{2871,
  abstract     = {{Gegenstand der Erfindung ist ein um seine ortsfeste, bevorzugt vertikale Achse oszillatorischrotierend angetriebener Reaktor für bevorzugt biotechnologische und pharmazeutische Anwendungen. Mit seinen prozessintensivierenden Eigenschaften für das Mischen, das Suspendieren, den Gasstofftransport, die Wärmeübertragung, die Bestrahlung und die Partikelrückhaltung wird die Anwendbarkeit im großtechnischen Maßstab gewährleistet. Der ohne Wellenabdichtung auskommende Reaktor erlaubt eine steriltechnisch besonders robuste Produktion unter Verzicht auf eine Reinigung und Reinigungsvalidierung erfordert, wenn der Reaktor als Einwegreaktor ausgeführt ist. }},
  author       = {{Brod, Helmut and Frahm, Björn and Kauling, Jörg and Poggel, Martin and Rose, Reinhold and Schmidt, Sebastian }},
  pages        = {{56}},
  title        = {{{Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen}}},
  year         = {{2007}},
}

@misc{2909,
  author       = {{Brod, Helmut and Frahm, Björn and Kauling, Jörg}},
  location     = {{Würzburg, Germany}},
  title        = {{{Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen}}},
  year         = {{2007}},
}

@misc{2910,
  author       = {{Brod, Helmut and Frahm, Björn and Kauling, Jörg}},
  location     = {{Osnabrück, Germany}},
  title        = {{{Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen}}},
  year         = {{2007}},
}

@misc{2967,
  author       = {{Frahm, Björn and Kirchner, S. and Rose, R. and Jenne, M. and Kauling, J. and Brod, H. and Jöris, K. and Wischniewski, M. and Langer, U. and Bödeker, B.}},
  location     = {{Leverkusen, Germany}},
  title        = {{{High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)}}},
  year         = {{2007}},
}

@misc{2347,
  author       = {{Frahm, Björn and Lane, Paul and Munack, Axel and Pörtner, Ralf}},
  booktitle    = {{Chemie Ingenieur Technik}},
  issn         = {{1522-2640}},
  number       = {{4}},
  pages        = {{429--435}},
  publisher    = {{WILEY-VCH Verlag}},
  title        = {{{Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode}}},
  doi          = {{10.1002/cite.200407094}},
  volume       = {{77}},
  year         = {{2005}},
}

@misc{2813,
  author       = {{Frahm, Björn and Pörtner, R.}},
  booktitle    = {{Animal Cell Technology Meets Genomics}},
  isbn         = {{1-4020-2791-5}},
  location     = {{Granada}},
  pages        = {{693--695}},
  publisher    = {{Springer}},
  title        = {{{Flexible Fed-Batch Process Control of Animal Cells}}},
  doi          = {{10.1007/1-4020-3103-3_142}},
  volume       = {{vol. 2}},
  year         = {{2005}},
}

@misc{2907,
  author       = {{Pörtner, Ralf and Frahm, Björn and Lane, P. and Munack, A.}},
  location     = {{Harrogate, UK}},
  title        = {{{Optimisation of time-space-yield for hybridoma fed-batch cultures with an adaptive OLFO-controller}}},
  year         = {{2005}},
}

@misc{2908,
  author       = {{Pörtner, R. and Frahm, Björn and Hass, V. C. and Lane, P. and Munack, A.}},
  location     = {{Wiesbaden, Germany}},
  title        = {{{Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode}}},
  year         = {{2005}},
}

@misc{2345,
  author       = {{Pörtner, Ralf and Schwabe, Jan-Oliver and Frahm, Björn}},
  booktitle    = {{Biotechnology and Applied Biochemistry}},
  issn         = {{1470-8744}},
  publisher    = {{Wiley-Blackwell}},
  title        = {{{Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line}}},
  doi          = {{10.1042/ba20030168}},
  volume       = {{40}},
  year         = {{2004}},
}

@misc{7934,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Manchester, UK}},
  title        = {{{Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies}}},
  year         = {{2003}},
}

@misc{2343,
  author       = {{Frahm, Björn and Hass, V. C. and Lane, P. and Munack, A. and Märkl, H. and Pörtner, R.}},
  booktitle    = {{Chemie Ingenieur Technik}},
  issn         = {{1522-2640}},
  number       = {{4}},
  pages        = {{457--460}},
  publisher    = {{WILEY-VCH Verlag}},
  title        = {{{Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung}}},
  doi          = {{10.1002/cite.200390093}},
  volume       = {{75}},
  year         = {{2003}},
}

@misc{2344,
  author       = {{Frahm, Björn and Lane, P. and Märkl, H. and Pörtner, R.}},
  booktitle    = {{Bioprocess and Biosystems Engineering}},
  issn         = {{1615-7591}},
  number       = {{1}},
  pages        = {{1--10}},
  publisher    = {{Springer}},
  title        = {{{Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis}}},
  doi          = {{10.1007/s00449-003-0335-z}},
  volume       = {{26}},
  year         = {{2003}},
}

@phdthesis{2393,
  abstract     = {{Die wirtschaftlich immer mehr an Bedeutung gewinnende Kultivierung tierischer Zelllinien umfasst zahlreiche Anwendungen in der Pharmaherstellung und Medizintechnik. Eine Vielzahl der Produkte (Diagnostika, Impfstoffe, Therapeutika) wird in Fed-Batch-Prozessen hergestellt. Für die verbesserte Steuerung von derartigen Fed-Batch-Prozessen stellt der Autor eine adaptive, modellgestützte Steuerung vor. Anwendungsbeispiele veranschaulichen das Potential und die Flexibilität der Steuerung und ihre Universalität bezüglich verschiedener Kultivierungssysteme und Zelllinien. 

Da auch die gelöst-CO2-Konzentration und die Atmungsaktivität der Zellen zunehmend Bedeutung in der Prozessführung erlangen, stellt dieses Buch weiterhin die entwickelte Erfassung dieser Größen per Abgasanalytik und Modellierung des Kohlendioxidtransfers vor.}},
  author       = {{Frahm, Björn}},
  isbn         = {{ 	978-3-8334-0111-4 }},
  keywords     = {{Tierzelle, Suspensionskultur, Prozesssteuerung}},
  pages        = {{120}},
  publisher    = {{Books on Demand GmbH}},
  title        = {{{Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen}}},
  year         = {{2003}},
}

@misc{2435,
  author       = {{Frahm, Björn and Müller-Landré, B. and Wiggers de Almeida, G. and Singer, M. and Rausch, M. and Lane, P. and Munack, A. and Hass, V. C. and Pörtner, R.}},
  booktitle    = {{Technische Systeme für Biotechnologie und Umwelt}},
  editor       = {{Beckmann, Dieter}},
  isbn         = {{3-00-011287-1}},
  location     = {{Heilbad Heiligenstadt}},
  pages        = {{503--509}},
  publisher    = {{Inst. für Bioprozess- und Analysenmesstechnik }},
  title        = {{{Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control}}},
  year         = {{2003}},
}

@misc{2436,
  author       = {{Kühn, K. and Frahm, Björn and Pörtner, R. and Lane, P. and Munack, A. and Hass, V. C.}},
  booktitle    = {{ ECCE - 4th European Congress of Chemical Engineering}},
  isbn         = {{84-88233-35-3}},
  location     = {{Granada}},
  publisher    = {{ECCE4}},
  title        = {{{Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells}}},
  volume       = {{10}},
  year         = {{2003}},
}

@inproceedings{2901,
  author       = {{Pörtner, R. and Frahm, Björn}},
  location     = {{Manchester, UK}},
  title        = {{{Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies}}},
  year         = {{2003}},
}

@misc{2902,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Göttingen, Germany}},
  title        = {{{Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung}}},
  year         = {{2003}},
}

@misc{2903,
  author       = {{Hass, V. C.  and Kühn, K. and Frahm, Björn and Pörtner, R. and Lane, P. and Munack, A.}},
  location     = {{München}},
  title        = {{{Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung}}},
  year         = {{2003}},
}

@misc{2905,
  author       = {{Frahm, Björn and Lane, P. and Munack, A. and Hass, V. C. and Pörtner, Ralf}},
  location     = {{Frankfurt am Main, Germany}},
  title        = {{{Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies}}},
  year         = {{2003}},
}

@misc{2906,
  author       = {{Pörtner, Ralf and Frahm, Björn and Lane, P. and Hass, V. C. and Munack, A. and Märkl, H.}},
  location     = {{Bad Dürkheim, Germany}},
  title        = {{{Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung}}},
  year         = {{2003}},
}

@misc{2964,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Manchester, UK}},
  title        = {{{CO2-off-gas measurement for animal cell culture processes}}},
  year         = {{2003}},
}

@misc{2965,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Granada, Spain}},
  title        = {{{Flexible fed-batch process control of animal cells}}},
  year         = {{2003}},
}

@misc{2966,
  author       = {{Kühn, K. and Frahm, Björn and Pörtner, Ralf and Lane, P. and Munack, A. and Hass, V. C.}},
  location     = {{Granada, Spain}},
  title        = {{{Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells}}},
  year         = {{2003}},
}

@misc{2340,
  author       = {{Frahm, Björn and Blank, H.-C. and Cornand, P. and Oelßner, W. and Guth, U. and Lane, P. and Munack, A. and Johannsen, K. and Pörtner, R.}},
  booktitle    = {{Journal of Biotechnology}},
  issn         = {{1873-4863 }},
  keywords     = {{Dissolved carbon dioxide, Carbon dioxide production rate, Carbon dioxide transfer rate, Off-gas measurement, Mammalian cell suspension culture}},
  number       = {{2}},
  pages        = {{133--148}},
  publisher    = {{Elsevier}},
  title        = {{{Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement}}},
  doi          = {{https://doi.org/10.1016/S0168-1656(02)00180-3}},
  volume       = {{99}},
  year         = {{2002}},
}

@misc{2341,
  author       = {{Frahm, Björn and Lane, P. and Atzert, H. and Munack, A. and Hoffmann, M. and Hass, V. C. and Pörtner, R.}},
  booktitle    = {{Biotechnology Progress}},
  issn         = {{1520-6033}},
  number       = {{5}},
  pages        = {{1095--1103}},
  publisher    = {{ Wiley }},
  title        = {{{Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells}}},
  doi          = {{10.1021/bp020035y}},
  volume       = {{18}},
  year         = {{2002}},
}

@misc{2342,
  author       = {{Frahm, Björn and Pörtner, R.}},
  booktitle    = {{BIOforum}},
  issn         = {{0940-0079}},
  pages        = {{179--180}},
  publisher    = {{GIT-Verlag}},
  title        = {{{Reaktor-Abgasmessungen bei Zellkulturen}}},
  volume       = {{4}},
  year         = {{2002}},
}

@misc{2431,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  booktitle    = {{Biosystemtechnik: Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung biotechnologischer Prozesse}},
  editor       = {{Kaden , Heiner }},
  isbn         = {{3-00-009026-6}},
  location     = {{Waldheim/Sa. }},
  pages        = {{39--48}},
  publisher    = {{Kurt-Schwabe-Inst. }},
  title        = {{{Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen}}},
  year         = {{2002}},
}

@misc{2897,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Wiesbaden, Germany}},
  title        = {{{Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen}}},
  year         = {{2002}},
}

@misc{2898,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Lonza Biologics, Slough, UK}},
  title        = {{{Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells}}},
  year         = {{2002}},
}

@misc{2899,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Birmingham, UK}},
  title        = {{{Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells}}},
  year         = {{2002}},
}

@misc{2900,
  author       = {{Frahm, Björn and Müller-Landré, B. and Wiggers de Almeida, G. and Singer, M. and Rausch, M. and Lane, P. and Munack, A. and Hass, V. C. and Pörtner, R.}},
  location     = {{Heilbad Heiligenstadt, Germany}},
  title        = {{{Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control}}},
  year         = {{2002}},
}

@misc{7933,
  author       = {{Frahm, Björn and Pörtner, Ralf}},
  location     = {{Waldheim, Germany}},
  title        = {{{Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen}}},
  year         = {{2001}},
}

@misc{2427,
  author       = {{Frahm, Björn and Atzert, H. and Lane, P. and Hoffmann, M. and Hass, V. C. and Munack, A. and Pörtner, Ralf}},
  booktitle    = {{Animal Cell Technology: From Target to Market}},
  isbn         = {{9789401038973}},
  pages        = {{446--448}},
  publisher    = {{Springer}},
  title        = {{{Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells}}},
  doi          = {{10.1007/978-94-010-0369-8_107}},
  volume       = {{vol. 1}},
  year         = {{2001}},
}

@misc{2429,
  author       = {{Hass, V. C. and Lane, P. and Hoffmann, M. and Frahm, Björn and Schwabe, J.-O. and Pörtner, R. and Munack, A.}},
  location     = {{Québec City, Québec, Canada}},
  title        = {{{Model-Based Control of Hybridoma Cell Cultures}}},
  year         = {{2001}},
}

@misc{2894,
  author       = {{Hoffmann, M. and Hass, V. C.  and Frahm, Björn and Schwabe, J.-O. and Pörtner, R. and Lane, P. and Munack, A.}},
  location     = {{Leipzig, Germany}},
  title        = {{{Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen}}},
  year         = {{2001}},
}

@misc{2895,
  author       = {{Frahm, Björn and Pörtner, R.}},
  location     = {{Hannover}},
  title        = {{{Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik}}},
  year         = {{2001}},
}

@misc{2960,
  author       = {{Frahm, Björn and Atzert, H. and Schwabe, J.-O. and Lane, P. and Munack, A. and Hoffmann, M. and Hass, V. C. and Pörtner, R.}},
  location     = {{Leipzig, Germany}},
  title        = {{{Adaptive modellgestützte Steuerung von Zellkulturprozessen}}},
  year         = {{2001}},
}

@misc{2961,
  author       = {{Lane, P. and Frahm, Björn and Atzert, H. and Schwabe, J.-O. and Hoffmann, M. and Hass, V. C. and Pörtner, R.}},
  location     = {{Leipzig, Germany}},
  title        = {{{Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities}}},
  year         = {{2001}},
}

@misc{2962,
  author       = {{Frahm, Björn and Atzert, H. and Lane, P. and Hoffmann, M. and Hass, V. C. and Munack, A. and Pörtner, R.}},
  location     = {{Tylösand, Sweden}},
  title        = {{{Development of an automated, model-based, adaptive control for the effective cultivation of hybridoma cells}}},
  year         = {{2001}},
}

@misc{2963,
  author       = {{Hass, V.C. and Lane, P. and Hoffmann, M. and Frahm, Björn and Schwabe, J.-O. and Pörtner, R. and Munack, A.}},
  booktitle    = {{Computer Applications in Biotechnology, 2001: Modelling, Monitoring and Control of Biotechnological Processes}},
  isbn         = {{ 0080436811 }},
  issn         = {{ 1474-6670 }},
  location     = {{Québec City, Québec, Canada}},
  pages        = {{323--329}},
  publisher    = {{ScienceDirect}},
  title        = {{{Model-Based Control of Hybridoma Cell Cultures}}},
  doi          = {{https://doi.org/10.1016/S1474-6670(17)34240-4}},
  volume       = {{34}},
  year         = {{2001}},
}

@misc{2893,
  author       = {{Anderelei, T. and Frahm, Björn and Büchs, J.}},
  location     = {{Bamberg, Germany}},
  title        = {{{Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren}}},
  year         = {{2000}},
}

@misc{2959,
  author       = {{Hoffmann, M. and Frahm, Björn and Schwabe, J.-O. and Lane, P. and Pörtner, R. and Hass, V. C. and Munack, A.}},
  location     = {{Heilbad Heiligenstadt, Germany}},
  title        = {{{Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus}}},
  year         = {{2000}},
}