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Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies. 2003."},"type":"conference_speech","conference":{"end_date":"2003-01-07","name":"13th ESACT UK Meeting","location":"Manchester, UK","start_date":"2003-01-06"},"year":2003},{"publication_status":"published","author":[{"id":"45666","full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm"},{"last_name":"Hass","full_name":"Hass, V. C.","first_name":"V. 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(2003)</b>: Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung, in: <i>Chemie Ingenieur Technik</i> <i>75</i> (<i>4</i>), S. 457–460.","chicago-de":"Frahm, Björn, V. C. Hass, P. Lane, A. Munack, H. Märkl und R. Pörtner. 2003. Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. <i>Chemie Ingenieur Technik</i> 75, Nr. 4: 457–460. doi:<a href=\"https://doi.org/10.1002/cite.200390093,\">10.1002/cite.200390093,</a> .","havard":"B. Frahm, V.C. Hass, P. Lane, A. Munack, H. Märkl, R. Pörtner, Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung, Chemie Ingenieur Technik. 75 (2003) 457–460.","short":"B. Frahm, V.C. Hass, P. Lane, A. Munack, H. Märkl, R. Pörtner, Chemie Ingenieur Technik 75 (2003) 457–460.","ama":"Frahm B, Hass VC, Lane P, Munack A, Märkl H, Pörtner R. 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Pörtner, “Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung,” <i>Chemie Ingenieur Technik</i>, vol. 75, no. 4, pp. 457–460, 2003.","mla":"Frahm, Björn, et al. “Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung.” <i>Chemie Ingenieur Technik</i>, vol. 75, no. 4, WILEY-VCH Verlag, 2003, pp. 457–60, doi:<a href=\"https://doi.org/10.1002/cite.200390093\">10.1002/cite.200390093</a>.","chicago":"Frahm, Björn, V. C. Hass, P. Lane, A. Munack, H. Märkl, and R. Pörtner. “Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung.” <i>Chemie Ingenieur Technik</i> 75, no. 4 (2003): 457–60. <a href=\"https://doi.org/10.1002/cite.200390093\">https://doi.org/10.1002/cite.200390093</a>."},"oa":"1","year":2003},{"page":"1-10","extern":"1","language":[{"iso":"eng"}],"_id":"2344","quality_controlled":"1","oa":"1","type":"scientific_journal_article","citation":{"havard":"B. Frahm, P. Lane, H. Märkl, R. Pörtner, Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis, Bioprocess and Biosystems Engineering. 26 (2003) 1–10.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Lane, P.</span> ; <span style=\"font-variant:small-caps;\">Märkl, H.</span> ; <span style=\"font-variant:small-caps;\">Pörtner, R.</span>: Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. In: <i>Bioprocess and Biosystems Engineering</i> Bd. 26, Springer (2003), Nr. 1, S. 1–10","ufg":"<b>Frahm, Björn et. al. (2003)</b>: Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis, in: <i>Bioprocess and Biosystems Engineering</i> <i>26</i> (<i>1</i>), S. 1–10.","bjps":"<b>Frahm B <i>et al.</i></b> (2003) Improvement of a Mammalian Cell Culture Process by Adaptive, Model-Based Dialysis Fed-Batch Cultivation and Suppression of Apoptosis. <i>Bioprocess and Biosystems Engineering</i> <b>26</b>, 1–10.","chicago-de":"Frahm, Björn, P. Lane, H. Märkl und R. Pörtner. 2003. Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. <i>Bioprocess and Biosystems Engineering</i> 26, Nr. 1: 1–10. doi:<a href=\"https://doi.org/10.1007/s00449-003-0335-z,\">10.1007/s00449-003-0335-z,</a> .","apa":"Frahm, B., Lane, P., Märkl, H., &#38; Pörtner, R. (2003). Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. <i>Bioprocess and Biosystems Engineering</i>, <i>26</i>(1), 1–10. <a href=\"https://doi.org/10.1007/s00449-003-0335-z\">https://doi.org/10.1007/s00449-003-0335-z</a>","mla":"Frahm, Björn, et al. “Improvement of a Mammalian Cell Culture Process by Adaptive, Model-Based Dialysis Fed-Batch Cultivation and Suppression of Apoptosis.” <i>Bioprocess and Biosystems Engineering</i>, vol. 26, no. 1, Springer, 2003, pp. 1–10, doi:<a href=\"https://doi.org/10.1007/s00449-003-0335-z\">10.1007/s00449-003-0335-z</a>.","chicago":"Frahm, Björn, P. Lane, H. Märkl, and R. Pörtner. “Improvement of a Mammalian Cell Culture Process by Adaptive, Model-Based Dialysis Fed-Batch Cultivation and Suppression of Apoptosis.” <i>Bioprocess and Biosystems Engineering</i> 26, no. 1 (2003): 1–10. <a href=\"https://doi.org/10.1007/s00449-003-0335-z\">https://doi.org/10.1007/s00449-003-0335-z</a>.","ama":"Frahm B, Lane P, Märkl H, Pörtner R. Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. <i>Bioprocess and Biosystems Engineering</i>. 2003;26(1):1-10. doi:<a href=\"https://doi.org/10.1007/s00449-003-0335-z\">10.1007/s00449-003-0335-z</a>","van":"Frahm B, Lane P, Märkl H, Pörtner R. Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. Bioprocess and Biosystems Engineering. 2003;26(1):1–10.","ieee":"B. Frahm, P. Lane, H. Märkl, and R. Pörtner, “Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis,” <i>Bioprocess and Biosystems Engineering</i>, vol. 26, no. 1, pp. 1–10, 2003.","short":"B. Frahm, P. Lane, H. Märkl, R. Pörtner, Bioprocess and Biosystems Engineering 26 (2003) 1–10."},"year":2003,"doi":"10.1007/s00449-003-0335-z","user_id":"45666","date_updated":"2023-03-15T13:49:39Z","main_file_link":[{"url":"https://link.springer.com/article/10.1007/s00449-003-0335-z","open_access":"1"}],"department":[{"_id":"DEP4021"}],"date_created":"2020-05-15T09:14:06Z","publication":"Bioprocess and Biosystems Engineering","issue":"1","status":"public","publication_status":"published","publisher":"Springer","author":[{"id":"45666","last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn"},{"first_name":"P.","full_name":"Lane, P.","last_name":"Lane"},{"full_name":"Märkl, H.","first_name":"H.","last_name":"Märkl"},{"full_name":"Pörtner, R.","first_name":"R.","last_name":"Pörtner"}],"volume":26,"intvolume":"        26","publication_identifier":{"issn":["1615-7591","1615-7605"]},"title":"Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis"},{"abstract":[{"text":"Die wirtschaftlich immer mehr an Bedeutung gewinnende Kultivierung tierischer Zelllinien umfasst zahlreiche Anwendungen in der Pharmaherstellung und Medizintechnik. Eine Vielzahl der Produkte (Diagnostika, Impfstoffe, Therapeutika) wird in Fed-Batch-Prozessen hergestellt. Für die verbesserte Steuerung von derartigen Fed-Batch-Prozessen stellt der Autor eine adaptive, modellgestützte Steuerung vor. Anwendungsbeispiele veranschaulichen das Potential und die Flexibilität der Steuerung und ihre Universalität bezüglich verschiedener Kultivierungssysteme und Zelllinien. \r\n\r\nDa auch die gelöst-CO2-Konzentration und die Atmungsaktivität der Zellen zunehmend Bedeutung in der Prozessführung erlangen, stellt dieses Buch weiterhin die entwickelte Erfassung dieser Größen per Abgasanalytik und Modellierung des Kohlendioxidtransfers vor.","lang":"ger"}],"_id":"2393","language":[{"iso":"ger"}],"publication_status":"published","author":[{"last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn","id":"45666"}],"place":"Norderstedt","publisher":"Books on Demand GmbH","page":"120","keyword":["Tierzelle","Suspensionskultur","Prozesssteuerung"],"status":"public","title":"Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen","date_created":"2020-05-19T14:44:50Z","department":[{"_id":"DEP4021"}],"date_updated":"2023-03-15T13:49:39Z","user_id":"45666","type":"dissertation","citation":{"short":"B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003.","ama":"Frahm B. <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH; 2003.","mla":"Frahm, Björn. <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Books on Demand GmbH, 2003.","chicago":"Frahm, Björn. <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH, 2003.","ieee":"B. Frahm, <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH, 2003.","van":"Frahm B. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH; 2003. 120 p.","chicago-de":"Frahm, Björn. 2003. <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH.","ufg":"<b>Frahm, Björn (2003)</b>: Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Norderstedt.","bjps":"<b>Frahm B</b> (2003) <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH.","apa":"Frahm, B. (2003). <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH.","havard":"B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. 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Frahm <i>et al.</i>, <i>Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control</i>. Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik , 2003, pp. 503–509.","chicago":"Frahm, Björn, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V. C. Hass, and R. Pörtner. <i>Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control</i>. Edited by Dieter Beckmann and Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld). <i>Technische Systeme Für Biotechnologie Und Umwelt</i>. 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