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","lang":"ger"},{"lang":"eng","text":"Bioreactor comprises a disposable bag, which has a reactor chamber (2) bounded by a wall (1), and light sources arranged in the immediate vicinity of the wall of the disposable bags. The bioreactor is designed as a photo-bioreactor. "}],"department":[{"_id":"DEP4021"}],"author":[{"id":"45666","first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn"},{"full_name":"Meier, Uwe","first_name":"Uwe","last_name":"Meier"}],"year":2014,"publication_date":"2014-01-06","page":"9","status":"public","title":"Beleuchtung von disposable Bioreaktoren","citation":{"short":"B. Frahm, U. Meier, (2014).","chicago-de":"Frahm, Björn und Uwe Meier. 2014. Beleuchtung von disposable Bioreaktoren.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Meier, Uwe</span>: Beleuchtung von disposable Bioreaktoren (2014)","van":"Frahm B, Meier U. 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Bundesalgenstammtisch","start_date":"2014-06-03","end_date":"2014-06-04"},"department":[{"_id":"DEP4021"}],"year":2014,"author":[{"first_name":"F.","last_name":"Drews","full_name":"Drews, F."},{"full_name":"Drews, G.","last_name":"Drews","first_name":"G."},{"full_name":"Folz, C.","first_name":"C.","last_name":"Folz"},{"first_name":"G.","full_name":"Platz, G.","last_name":"Platz"},{"first_name":"Thomas","id":"12675","last_name":"Gassenmeier","full_name":"Gassenmeier, Thomas"},{"full_name":"Kramer, M.","last_name":"Kramer","first_name":"M."},{"last_name":"Hundeiker","first_name":"C.","full_name":"Hundeiker, C."},{"full_name":"Schwarze, B.","first_name":"B.","last_name":"Schwarze"},{"last_name":"Frahm","id":"45666","first_name":"Björn","full_name":"Frahm, Björn"}],"publication_status":"published","citation":{"apa":"Drews, F., Drews, G., Folz, C., Platz, G., Gassenmeier, T., Kramer, M., … Frahm, B. (2014). <i>Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche</i>. Presented at the 7. Bundesalgenstammtisch, Köthen, Germany.","chicago":"Drews, F., G. Drews, C. Folz, G. Platz, Thomas Gassenmeier, M. Kramer, C. Hundeiker, B. Schwarze, and Björn Frahm. <i>Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche</i>, 2014.","van":"Drews F, Drews G, Folz C, Platz G, Gassenmeier T, Kramer M, et al. Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. 2014.","mla":"Drews, F., et al. <i>Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche</i>. 2014.","havard":"F. Drews, G. Drews, C. Folz, G. Platz, T. Gassenmeier, M. Kramer, C. Hundeiker, B. Schwarze, B. 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Frahm, Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche, 2014.","din1505-2-1":"<span style=\"font-variant:small-caps;\"><span style=\"font-variant:small-caps;\">Drews, F.</span> ; <span style=\"font-variant:small-caps;\">Drews, G.</span> ; <span style=\"font-variant:small-caps;\">Folz, C.</span> ; <span style=\"font-variant:small-caps;\">Platz, G.</span> ; <span style=\"font-variant:small-caps;\">Gassenmeier, Thomas</span> ; <span style=\"font-variant:small-caps;\">Kramer, M.</span> ; <span style=\"font-variant:small-caps;\">Hundeiker, C.</span> ; <span style=\"font-variant:small-caps;\">Schwarze, B.</span> ; u. a.</span>: <i>Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche</i>, 2014","chicago-de":"Drews, F., G. Drews, C. Folz, G. Platz, Thomas Gassenmeier, M. Kramer, C. Hundeiker, B. Schwarze und Björn Frahm. 2014. <i>Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche</i>.","ieee":"F. Drews <i>et al.</i>, <i>Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche</i>. 2014.","ama":"Drews F, Drews G, Folz C, et al. <i>Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche</i>.; 2014."},"title":"Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche","_id":"2984","language":[{"iso":"ger"}],"date_updated":"2023-03-15T13:49:44Z","user_id":"45666","type":"conference_poster","date_created":"2020-06-22T13:33:18Z"},{"place":"Totowa, NJ","doi":"10.1007/978-1-62703-733-4_22","_id":"2394","user_id":"74004","intvolume":"      1104","type":"book_chapter","publisher":"Humana Press","department":[{"_id":"DEP4021"}],"abstract":[{"lang":"eng","text":"For the production of biopharmaceuticals a seed train is required to generate an adequate number of cells for inoculation of the production bioreactor. This seed train is time- and cost-intensive but offers potential for optimization. A method and a protocol are described for the seed train mapping, directed modeling without major effort, and its optimization regarding selected optimization criteria such as optimal points in time for cell passaging. Furthermore, the method can also be applied for the set-up of a new seed train, for example for a new cell line. Although the chapter is directed towards suspension cell lines, the method is also generally applicable, e.g. for adherent cell lines."}],"publication_status":"published","series_title":"Methods in Molecular Biology ","language":[{"iso":"eng"}],"keyword":["Seed train Optimization Modeling Prediction Space-Time-Yield (STY) Systems approach Bioinformatics Computational biotechnology Suspension Production"],"date_updated":"2023-03-15T13:49:39Z","date_created":"2020-05-19T14:45:43Z","publication":"Animal Cell Biotechnology","publication_identifier":{"issn":["1064-3745","1940-6029"],"eisbn":["9781627037334"],"isbn":["9781627037327"]},"page":"355-367","status":"public","author":[{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm"}],"year":2013,"volume":1104,"citation":{"ieee":"B. Frahm, “Seed Train Optimization for Cell Culture,” in <i>Animal Cell Biotechnology</i>, vol. 1104, Totowa, NJ: Humana Press, 2013, pp. 355–367.","ama":"Frahm B. 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Pörtner, and Björn Frahm. <i>Seed Train Optimization for Suspension Cell Culture</i>, 2013.","ieee":"T. Hernández Rodriguez, R. Pörtner, and B. Frahm, <i>Seed train optimization for suspension cell culture</i>. 2013.","apa":"Hernández Rodriguez, T., Pörtner, R., &#38; Frahm, B. (2013). <i>Seed train optimization for suspension cell culture</i>. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.","havard":"T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, 2013.","mla":"Hernández Rodriguez, Tanja, et al. <i>Seed Train Optimization for Suspension Cell Culture</i>. 2013.","bjps":"<b>Hernández Rodriguez T, Pörtner R and Frahm B</b> (2013) <i>Seed Train Optimization for Suspension Cell Culture</i>. .","ufg":"<b>Hernández Rodriguez, Tanja et. al. 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Frahm, Seed Train Optimization for Suspension Cell Culture, 2013."},"publication_status":"published"},{"date_updated":"2023-03-15T13:49:43Z","publication":"Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009","publication_identifier":{"isbn":["978-94-007-0883-9"],"eissn":["978-94-007-0884-6"]},"date_created":"2020-06-04T13:19:37Z","language":[{"iso":"eng"}],"oa":"1","volume":"vol. 5","citation":{"ieee":"B. Frahm and H. Brod, <i>Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA)</i>, vol. 5. Dordrecht: Springer, 2012, pp. 355–359.","ama":"Frahm B, Brod H. <i>Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA)</i>. Vol 5. Dordrecht: Springer; 2012:355-359. doi:<a href=\"https://doi.org/10.1007/978-94-007-0884-6_56\">10.1007/978-94-007-0884-6_56</a>","chicago-de":"Frahm, Björn und H. 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Brod. <i>Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA)</i>. <i>Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009</i>. Vol. 5. ESACT Proceedings. Dordrecht: Springer, 2012. <a href=\"https://doi.org/10.1007/978-94-007-0884-6_56\">https://doi.org/10.1007/978-94-007-0884-6_56</a>.","apa":"Frahm, B., &#38; Brod, H. (2012). <i>Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA)</i>. <i>Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009</i> (Vol. 5, pp. 355–359). Dordrecht: Springer. <a href=\"https://doi.org/10.1007/978-94-007-0884-6_56\">https://doi.org/10.1007/978-94-007-0884-6_56</a>","mla":"Frahm, Björn, and H. Brod. “Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA).” <i>Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009</i>, vol. 5, Springer, 2012, pp. 355–59, doi:<a href=\"https://doi.org/10.1007/978-94-007-0884-6_56\">10.1007/978-94-007-0884-6_56</a>.","bjps":"<b>Frahm B and Brod H</b> (2012) <i>Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA)</i>. Dordrecht: Springer.","havard":"B. Frahm, H. Brod, Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA), Springer, Dordrecht, 2012.","ufg":"<b>Frahm, Björn/Brod, H. (2012)</b>: Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA) (=<i>ESACT Proceedings 5</i>), Dordrecht.","van":"Frahm B, Brod H. Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. Dordrecht: Springer; 2012. (ESACT Proceedings; vol. 5)."},"title":"Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA)","extern":"1","status":"public","page":"355-359","year":2012,"author":[{"full_name":"Frahm, Björn","id":"45666","last_name":"Frahm","first_name":"Björn"},{"last_name":"Brod","first_name":"H.","full_name":"Brod, H."}],"main_file_link":[{"url":"https://link.springer.com/book/10.1007%2F978-94-007-0884-6","open_access":"1"}],"user_id":"45666","type":"conference_editor_article","_id":"2816","doi":"10.1007/978-94-007-0884-6_56","place":"Dordrecht","publication_status":"published","series_title":"ESACT Proceedings","publisher":"Springer","department":[{"_id":"DEP4021"}],"conference":{"end_date":"2009-06-10","start_date":"2009-06-07","name":"21st Annual Meeting of the European Society for Animal Cell Technology (ESACT)","location":" Dublin, Ireland"}},{"_id":"2877","ipn":"EP000002520642A1","ipc":"C12M 1/00 ","alternative_title":["Photo-bioreactor with rotary oscillating light sources"],"user_id":"45666","date_updated":"2023-03-15T13:49:43Z","type":"patent","date_created":"2020-06-05T14:32:12Z","status":"public","page":"19","publication_date":"2012-11-07","year":2012,"author":[{"first_name":"Helmut","full_name":"Brod, Helmut","last_name":"Brod"},{"last_name":"Frahm","first_name":"Björn","id":"45666","full_name":"Frahm, Björn"}],"department":[{"_id":"DEP4021"}],"abstract":[{"text":"Die Erfindung betrifft einen Photobioreaktor mit Belichtung durch rotatorisch oszillierend bewegte Lichtquellen (Lichtleiter, LEDs) sowie optional kombiniert rotatorisch oszillierend bewegte Membranflächen zum Gastransport. Vorteile sind unter anderem ein im zeitlichen Mittel räumlich homogener Lichteintrag, welcher über Intensität und Oszillation an die Kultur und deren Dichte angepasst werden kann, sowie ein scherarmer Leistungseintrag und optional eine scherarme blasenfreie Be- und Entgasung. ","lang":"ger"},{"text":"Photobioreactor comprises light sources, which are arbitrarily movable in rotational oscillation distributed in a bioreactor liquid volume. An independent claim is also included for using the photobioreactor, comprising executing an arbitrary discontinuous movement using the light sources.  ","lang":"eng"}],"application_date":"2012-05-02","application_number":" \t12166475","citation":{"chicago":"Brod, Helmut, and Björn Frahm. “Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen,” 2012.","apa":"Brod, H., &#38; Frahm, B. (2012). Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.","ieee":"H. Brod and B. Frahm, “Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.” 2012.","ufg":"<b>Brod, Helmut/Frahm, Björn (2012)</b>: Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.","havard":"H. Brod, B. Frahm, Photobioreaktor mit rotatorisch oszillierenden Lichtquellen, (2012).","bjps":"<b>Brod H and Frahm B</b> (2012) Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen.","mla":"Brod, Helmut, and Björn Frahm. <i>Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen</i>. 2012.","van":"Brod H, Frahm B. Photobioreaktor mit rotatorisch oszillierenden Lichtquellen. 2012.","ama":"Brod H, Frahm B. Photobioreaktor mit rotatorisch oszillierenden Lichtquellen. 2012.","chicago-de":"Brod, Helmut und Björn Frahm. 2012. Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Photobioreaktor mit rotatorisch oszillierenden Lichtquellen (2012)","short":"H. Brod, B. Frahm, (2012)."},"title":"Photobioreaktor mit rotatorisch oszillierenden Lichtquellen","extern":"1"},{"conference":{"location":"Frankfurt am Main, Germany","name":"ACHEMA 2012","end_date":"2012-06-22","start_date":"2012-06-18"},"department":[{"_id":"DEP4021"}],"author":[{"first_name":"W.","full_name":"Van Hecke, W.","last_name":"Van Hecke"},{"full_name":"Haltrich, D.","first_name":"D.","last_name":"Haltrich"},{"last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn","id":"45666"},{"first_name":"H.","last_name":"Brod","full_name":"Brod, H."},{"first_name":"R.","last_name":"Ludwig","full_name":"Ludwig, R."}],"year":2012,"publisher":"Vogel Business Media","status":"public","title":"Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor","publication_status":"published","citation":{"ama":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. <i>Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor</i>. 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Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, Vogel Business Media, 2012.","ufg":"<b>Van Hecke, W. et. al. (2012)</b>: Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor.","havard":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor, Vogel Business Media, 2012.","bjps":"<b>Van Hecke W <i>et al.</i></b> (2012) <i>Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor</i>. Vogel Business Media.","mla":"Van Hecke, W., et al. “Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor.” <i>Achema 2012</i>, Vogel Business Media, 2012.","van":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. 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Frankfurt am Main, Germany: Vogel Business Media."},"_id":"2918","language":[{"iso":"eng"}],"date_created":"2020-06-15T14:30:34Z","type":"conference_speech","publication":"Achema 2012","date_updated":"2023-03-15T13:49:43Z","user_id":"45666"},{"language":[{"iso":"ger"}],"_id":"2973","user_id":"45666","date_updated":"2023-03-15T13:49:44Z","date_created":"2020-06-18T14:31:21Z","type":"conference_poster","status":"public","author":[{"full_name":"Marzougui, R.","first_name":"R.","last_name":"Marzougui"},{"first_name":"R.","full_name":"Pörtner, R.","last_name":"Pörtner"},{"last_name":"Frahm","first_name":"Björn","id":"45666","full_name":"Frahm, Björn"}],"year":2012,"conference":{"location":"Freiburg, Germany","name":"GVC / DECHEMA Vortrags- und Diskussionstagung “Biopharmazeutische Produktion”","start_date":"2012-05-14","end_date":"2012-05-16"},"department":[{"_id":"DEP4021"}],"citation":{"chicago-de":"Marzougui, R., R. Pörtner und Björn Frahm. 2012. <i>Optimierung des Seed trains von Suspensions-Zellkulturen</i>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Marzougui, R.</span> ; <span style=\"font-variant:small-caps;\">Pörtner, R.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>Optimierung des Seed trains von Suspensions-Zellkulturen</i>, 2012","short":"R. Marzougui, R. Pörtner, B. Frahm, Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.","havard":"R. Marzougui, R. Pörtner, B. Frahm, Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.","mla":"Marzougui, R., et al. <i>Optimierung des Seed trains von Suspensions-Zellkulturen</i>. 2012.","bjps":"<b>Marzougui R, Pörtner R and Frahm B</b> (2012) <i>Optimierung des Seed trains von Suspensions-Zellkulturen</i>. .","ufg":"<b>Marzougui, R. et. al. (2012)</b>: Optimierung des Seed trains von Suspensions-Zellkulturen.","ama":"Marzougui R, Pörtner R, Frahm B. <i>Optimierung des Seed trains von Suspensions-Zellkulturen</i>.; 2012.","van":"Marzougui R, Pörtner R, Frahm B. Optimierung des Seed trains von Suspensions-Zellkulturen. 2012.","chicago":"Marzougui, R., R. Pörtner, and Björn Frahm. <i>Optimierung des Seed trains von Suspensions-Zellkulturen</i>, 2012.","ieee":"R. Marzougui, R. Pörtner, and B. Frahm, <i>Optimierung des Seed trains von Suspensions-Zellkulturen</i>. 2012.","apa":"Marzougui, R., Pörtner, R., &#38; Frahm, B. (2012). <i>Optimierung des Seed trains von Suspensions-Zellkulturen</i>. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung “Biopharmazeutische Produktion,” Freiburg, Germany."},"publication_status":"published","title":"Optimierung des Seed trains von Suspensions-Zellkulturen"},{"quality_controlled":"1","publisher":"Elsevier","issue":"2","department":[{"_id":"DEP4021"}],"publication_status":"published","doi":"10.1016/j.molcatb.2010.10.004","_id":"2350","intvolume":"        68","user_id":"45666","type":"scientific_journal_article","page":"154-161","status":"public","author":[{"last_name":"Van Hecke","first_name":"Wouter","full_name":"Van Hecke, Wouter"},{"first_name":"Dietmar","last_name":"Haltrich","full_name":"Haltrich, Dietmar"},{"last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn","id":"45666"},{"first_name":"Helmut","full_name":"Brod, Helmut","last_name":"Brod"},{"last_name":"Dewulf","full_name":"Dewulf, Jo","first_name":"Jo"},{"last_name":"Van Langenhove","first_name":"Herman","full_name":"Van Langenhove, Herman"},{"full_name":"Ludwig, Roland","last_name":"Ludwig","first_name":"Roland"}],"main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S1381117710002663"}],"year":2011,"volume":68,"citation":{"ama":"Van Hecke W, Haltrich D, Frahm B, et al. A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. <i>Journal of Molecular Catalysis B: Enzymatic</i>. 2011;68(2):154-161. doi:<a href=\"https://doi.org/10.1016/j.molcatb.2010.10.004\">10.1016/j.molcatb.2010.10.004</a>","ieee":"W. Van Hecke <i>et al.</i>, “A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor,” <i>Journal of Molecular Catalysis B: Enzymatic</i>, vol. 68, no. 2, pp. 154–161, 2011.","van":"Van Hecke W, Haltrich D, Frahm B, Brod H, Dewulf J, Van Langenhove H, et al. A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic. 2011;68(2):154–61.","ufg":"<b>Van Hecke, Wouter et. al. 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A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. <i>Journal of Molecular Catalysis B: Enzymatic</i> 68, Nr. 2: 154–161. doi:<a href=\"https://doi.org/10.1016/j.molcatb.2010.10.004,\">10.1016/j.molcatb.2010.10.004,</a> .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Van Hecke, Wouter</span> ; <span style=\"font-variant:small-caps;\">Haltrich, Dietmar</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Dewulf, Jo</span> ; <span style=\"font-variant:small-caps;\">Van Langenhove, Herman</span> ; <span style=\"font-variant:small-caps;\">Ludwig, Roland</span>: A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. In: <i>Journal of Molecular Catalysis B: Enzymatic</i> Bd. 68, Elsevier (2011), Nr. 2, S. 154–161"},"extern":"1","title":"A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor","language":[{"iso":"eng"}],"date_updated":"2023-03-15T13:49:39Z","date_created":"2020-05-15T10:21:22Z","publication":"Journal of Molecular Catalysis B: Enzymatic","publication_identifier":{"issn":["1381-1177"],"eisbn":["1873-3158"]}},{"title":"Flüssigkeitsbegaser","extern":"1","application_number":"2010005442 ","citation":{"apa":"Brod, H., Frahm, B., Jenne, M., Kauling, J., Schmitt, F., &#38; Seletzky, J. (2011). Flüssigkeitsbegaser.","chicago":"Brod, Helmut, Björn Frahm, Marc Jenne, Jörg Kauling, Franz Schmitt, and Juri Seletzky. “Flüssigkeitsbegaser,” 2011.","van":"Brod H, Frahm B, Jenne M, Kauling J, Schmitt F, Seletzky J. Flüssigkeitsbegaser. 2011.","mla":"Brod, Helmut, et al. <i>Flüssigkeitsbegaser</i>. 2011.","havard":"H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, J. Seletzky, Flüssigkeitsbegaser, (2011).","bjps":"<b>Brod H <i>et al.</i></b> (2011) Flüssigkeitsbegaser.","ufg":"<b>Brod, Helmut et. al. (2011)</b>: Flüssigkeitsbegaser.","short":"H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, J. Seletzky, (2011).","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Jenne, Marc</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span> ; <span style=\"font-variant:small-caps;\">Schmitt, Franz</span> ; <span style=\"font-variant:small-caps;\">Seletzky, Juri</span>: Flüssigkeitsbegaser (2011)","chicago-de":"Brod, Helmut, Björn Frahm, Marc Jenne, Jörg Kauling, Franz Schmitt und Juri Seletzky. 2011. Flüssigkeitsbegaser.","ieee":"H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, and J. Seletzky, “Flüssigkeitsbegaser.” 2011.","ama":"Brod H, Frahm B, Jenne M, Kauling J, Schmitt F, Seletzky J. Flüssigkeitsbegaser. 2011."},"year":2011,"author":[{"last_name":"Brod","full_name":"Brod, Helmut","first_name":"Helmut"},{"first_name":"Björn","id":"45666","full_name":"Frahm, Björn","last_name":"Frahm"},{"last_name":"Jenne","first_name":"Marc","full_name":"Jenne, Marc"},{"full_name":"Kauling, Jörg","first_name":"Jörg","last_name":"Kauling"},{"full_name":"Schmitt, Franz","first_name":"Franz","last_name":"Schmitt"},{"first_name":"Juri","full_name":"Seletzky, Juri","last_name":"Seletzky"}],"department":[{"_id":"DEP4021"}],"application_date":"2010-09-04","abstract":[{"text":"Die Erfindung betrifft einen Begaser zum Eintrag eines Gases oder Gasgemisches in eine Flüssigkeit sowie ein Verfahren zur Begasung von Flüssigkeiten. Der erf?ndungsgemäße Begaser umfasst einen Hohlraum, einen Gaseinlass zum Einleiten eines Gases in den Hohlraum und zwei oder mehr Flächen, die formschlüssig aufeinander gepresst sind oder gepresst werden können, so dass ein durch den Gaseinlass in den Hohlraum gedrücktes Gas durch die zwischen den zusammengepressten Flächen auftretenden Spalten entweicht. ","lang":"ger"},{"lang":"eng","text":" The invention relates to an aerator for introducing a gas or gas mixture into a liquid and to a method for aerating liquids. The aerator according to the invention comprises a cavity, a gas inlet for directing a gas into the cavity and two or more surfaces that are or can be pressed against one another in a form-fit such that a gas that is forced into the cavity by means of the gas inlet escapes through gaps that form between the compressed surfaces. "}],"status":"public","page":"32","publication_date":"2011-03-24","type":"patent","date_created":"2020-06-05T14:28:44Z","user_id":"45666","date_updated":"2023-03-15T13:49:43Z","ipn":"O002011032652A1     ","ipc":"C12M 1/08 ","alternative_title":["Liquid Aerator"],"_id":"2876"},{"citation":{"ieee":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, and R. Ludwig, <i>Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor</i>. 2011.","ama":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. <i>Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor</i>.; 2011.","short":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, 2011.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Van Hecke, W.</span> ; <span style=\"font-variant:small-caps;\">Haltrich, D.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Brod, H.</span> ; <span style=\"font-variant:small-caps;\">Ludwig, R.</span>: <i>Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor</i>, 2011","chicago-de":"Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod und R. Ludwig. 2011. <i>Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor</i>.","apa":"Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., &#38; Ludwig, R. (2011). <i>Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor</i>. Presented at the 1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting, Berlin, Germany.","chicago":"Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod, and R. Ludwig. <i>Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor</i>, 2011.","van":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. 2011.","ufg":"<b>Van Hecke, W. et. al. (2011)</b>: Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor.","bjps":"<b>Van Hecke W <i>et al.</i></b> (2011) <i>Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor</i>. .","havard":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor, 2011.","mla":"Van Hecke, W., et al. <i>Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor</i>. 2011."},"publication_status":"published","title":"Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor","extern":"1","status":"public","author":[{"first_name":"W.","last_name":"Van Hecke","full_name":"Van Hecke, W."},{"first_name":"D.","full_name":"Haltrich, D.","last_name":"Haltrich"},{"full_name":"Frahm, Björn","last_name":"Frahm","id":"45666","first_name":"Björn"},{"last_name":"Brod","full_name":"Brod, H.","first_name":"H."},{"first_name":"R.","last_name":"Ludwig","full_name":"Ludwig, R."}],"year":2011,"conference":{"name":"1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting","location":"Berlin, Germany","end_date":"2011-09-29","start_date":"2011-09-25"},"department":[{"_id":"DEP4021"}],"user_id":"45666","date_updated":"2023-03-15T13:49:44Z","type":"conference_poster","date_created":"2020-06-18T14:28:39Z","_id":"2972","language":[{"iso":"eng"}]},{"language":[{"iso":"eng"}],"_id":"2815","publication":"Proceedings 19th International Congress of Chemical and Process Engineering","publication_identifier":{"isbn":["978-80-02-02250-3","978-80-02-02210-7 (CD-ROM)"]},"date_created":"2020-06-04T13:18:51Z","type":"conference_editor_article","user_id":"45666","date_updated":"2023-03-15T13:49:43Z","year":2010,"author":[{"last_name":"Dercks","full_name":"Dercks, B.","first_name":"B."},{"last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn","id":"45666"},{"first_name":"M.","full_name":"Grünewald, M.","last_name":"Grünewald"},{"first_name":"E.","last_name":"Kenig","full_name":"Kenig, E."},{"full_name":"Lautenschleger, A.","first_name":"A.","last_name":"Lautenschleger"},{"first_name":"A.","full_name":"Gorak, A.","last_name":"Gorak"},{"full_name":"Schmidt, P. ","first_name":"P. ","last_name":"Schmidt"},{"last_name":"Sudhoff","first_name":"D.","full_name":"Sudhoff, D."},{"first_name":"S.","full_name":"Ressler, S.","last_name":"Ressler"},{"first_name":"R.","full_name":"Zecirovic, R.","last_name":"Zecirovic"}],"department":[{"_id":"DEP4021"}],"conference":{"location":"Prague, CZ","name":"7th European Congress of Chemical Engineering ; 19th International Congress of Chemical and Process Engineering","end_date":"2010-09-01","start_date":"2010-08-28"},"status":"public","publisher":"Czech Society of Chemical Engineering","title":"Intensified absorption and distillation devices for modular chemical production processes","extern":"1","citation":{"din1505-2-1":"<span style=\"font-variant:small-caps;\"><span style=\"font-variant:small-caps;\">Dercks, B.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Grünewald, M.</span> ; <span style=\"font-variant:small-caps;\">Kenig, E.</span> ; <span style=\"font-variant:small-caps;\">Lautenschleger, A.</span> ; <span style=\"font-variant:small-caps;\">Gorak, A.</span> ; <span style=\"font-variant:small-caps;\">Schmidt, P. </span> ; <span style=\"font-variant:small-caps;\">Sudhoff, D.</span> ; u. a.</span>: <i>Intensified absorption and distillation devices for modular chemical production processes</i> : Czech Society of Chemical Engineering, 2010","chicago-de":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P.  Schmidt, D. Sudhoff, S. Ressler und R. Zecirovic. 2010. <i>Intensified absorption and distillation devices for modular chemical production processes</i>. <i>Proceedings 19th International Congress of Chemical and Process Engineering</i>. Czech Society of Chemical Engineering.","short":"B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, Czech Society of Chemical Engineering, 2010.","havard":"B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified absorption and distillation devices for modular chemical production processes, Czech Society of Chemical Engineering, 2010.","mla":"Dercks, B., et al. “Intensified Absorption and Distillation Devices for Modular Chemical Production Processes.” <i>Proceedings 19th International Congress of Chemical and Process Engineering</i>, Czech Society of Chemical Engineering, 2010.","bjps":"<b>Dercks B <i>et al.</i></b> (2010) <i>Intensified Absorption and Distillation Devices for Modular Chemical Production Processes</i>. Czech Society of Chemical Engineering.","ufg":"<b>Dercks, B. et. al. (2010)</b>: Intensified absorption and distillation devices for modular chemical production processes.","ama":"Dercks B, Frahm B, Grünewald M, et al. <i>Intensified Absorption and Distillation Devices for Modular Chemical Production Processes</i>. Czech Society of Chemical Engineering; 2010.","van":"Dercks B, Frahm B, Grünewald M, Kenig E, Lautenschleger A, Gorak A, et al. Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering; 2010.","chicago":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P.  Schmidt, D. Sudhoff, S. Ressler, and R. Zecirovic. <i>Intensified Absorption and Distillation Devices for Modular Chemical Production Processes</i>. <i>Proceedings 19th International Congress of Chemical and Process Engineering</i>. Czech Society of Chemical Engineering, 2010.","ieee":"B. Dercks <i>et al.</i>, <i>Intensified absorption and distillation devices for modular chemical production processes</i>. Czech Society of Chemical Engineering, 2010.","apa":"Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). <i>Intensified absorption and distillation devices for modular chemical production processes</i>. <i>Proceedings 19th International Congress of Chemical and Process Engineering</i>. Prague, CZ: Czech Society of Chemical Engineering."},"publication_status":"published"},{"abstract":[{"lang":"ger","text":"Die Erfindung betrifft ein Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen, insbesondere von Zellkulturen, welche zur Agglomeration bzw. Anhaftung an den Bioreaktor und seine Elemente neigen, oder bei denen Zelldebris oder Substanzen leicht agglomerieren bzw. anhaften."},{"lang":"eng","text":"The invention relates to a method for reducing deposits during the cultivation of organisms, particularly cell cultures, which tend to agglomerate or adhere to the bioreactor and the elements thereof, or in which cell debris or substances easily agglomerate or adhere. "}],"application_date":"2009-09-17","author":[{"last_name":"Brod","full_name":"Brod, Helmut","first_name":"Helmut"},{"last_name":"Frahm","id":"45666","full_name":"Frahm, Björn","first_name":"Björn"},{"first_name":"Jörg","last_name":"Kauling","full_name":"Kauling, Jörg"}],"year":2010,"department":[{"_id":"DEP4021"}],"publication_date":"2010-04-01","status":"public","page":"26","title":"Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen","extern":"1","citation":{"ama":"Brod H, Frahm B, Kauling J. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen. 2010.","ieee":"H. Brod, B. Frahm, and J. Kauling, “Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.” 2010.","short":"H. Brod, B. Frahm, J. Kauling, (2010).","chicago-de":"Brod, Helmut, Björn Frahm und Jörg Kauling. 2010. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span>: Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen (2010)","van":"Brod H, Frahm B, Kauling J. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen. 2010.","havard":"H. Brod, B. Frahm, J. Kauling, Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen, (2010).","mla":"Brod, Helmut, et al. <i>Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen</i>. 2010.","bjps":"<b>Brod H, Frahm B and Kauling J</b> (2010) Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen.","ufg":"<b>Brod, Helmut et. al. (2010)</b>: Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","apa":"Brod, H., Frahm, B., &#38; Kauling, J. (2010). Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","chicago":"Brod, Helmut, Björn Frahm, and Jörg Kauling. “Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen,” 2010."},"application_number":"2009006722 ","ipc":"C12N 5/00","alternative_title":["Method for reducing deposits during the cultivation of organisms"],"ipn":"WO002010034428A2","_id":"2873","date_created":"2020-06-05T14:12:21Z","type":"patent","user_id":"45666","date_updated":"2023-03-15T13:49:43Z"},{"date_created":"2020-06-05T14:17:50Z","type":"patent","user_id":"45666","date_updated":"2023-03-15T13:49:43Z","ipc":"C12M 1/04","alternative_title":["Mikrogespargter Air-Lift-Bioreaktor für die Zellkultur"],"ipn":"WO002010069492A1","_id":"2874","title":"Bioreaktor","extern":"1","citation":{"short":"H. Brod, B. Frahm, M. Jenne, J. Kauling, (2010).","chicago-de":"Brod, Helmut, Björn Frahm, Marc Jenne und Jörg Kauling. 2010. Bioreaktor.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Jenne, Marc</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span>: Bioreaktor (2010)","apa":"Brod, H., Frahm, B., Jenne, M., &#38; Kauling, J. (2010). Bioreaktor.","ieee":"H. Brod, B. Frahm, M. Jenne, and J. Kauling, “Bioreaktor.” 2010.","chicago":"Brod, Helmut, Björn Frahm, Marc Jenne, and Jörg Kauling. “Bioreaktor,” 2010.","van":"Brod H, Frahm B, Jenne M, Kauling J. Bioreaktor. 2010.","ama":"Brod H, Frahm B, Jenne M, Kauling J. Bioreaktor. 2010.","ufg":"<b>Brod, Helmut et. al. (2010)</b>: Bioreaktor.","havard":"H. Brod, B. Frahm, M. Jenne, J. Kauling, Bioreaktor, (2010).","mla":"Brod, Helmut, et al. <i>Bioreaktor</i>. 2010.","bjps":"<b>Brod H <i>et al.</i></b> (2010) Bioreaktor."},"application_number":"2009008733 ","application_date":"2009-12-08","abstract":[{"lang":"ger","text":"Die Erfindung betrifft einen Bioreaktor, die Verwendung des Bioreaktors zur Kultivierung von Mikroorganismen oder Zellkulturen sowie ein Verfahren zur Kultivierung von Mikroorganismen oder Zellkulturen. "},{"text":"The invention relates to a bioreactor, to the use of the bioreactor for culturing microorganisms or cell cultures, and also to a method for culturing microorganisms or cell cultures. ","lang":"eng"}],"author":[{"last_name":"Brod","full_name":"Brod, Helmut","first_name":"Helmut"},{"full_name":"Frahm, Björn","id":"45666","last_name":"Frahm","first_name":"Björn"},{"full_name":"Jenne, Marc","first_name":"Marc","last_name":"Jenne"},{"first_name":"Jörg","last_name":"Kauling","full_name":"Kauling, Jörg"}],"year":2010,"department":[{"_id":"DEP4021"}],"publication_date":"2010-06-24","status":"public","page":"27"},{"date_created":"2020-06-05T14:22:30Z","type":"patent","user_id":"45666","date_updated":"2023-03-15T13:49:43Z","alternative_title":["Gassing System"],"ipc":"C12M 1/04 ","ipn":"WO002010083956A2","_id":"2875","title":"Begasungssystem","extern":"1","citation":{"short":"B. Frahm, J. Kauling, A. Pütz, M. Schindler, (2010).","chicago-de":"Frahm, Björn, Jörg Kauling, Andre Pütz und Markus Schindler. 2010. Begasungssystem.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span> ; <span style=\"font-variant:small-caps;\">Pütz, Andre</span> ; <span style=\"font-variant:small-caps;\">Schindler, Markus</span>: Begasungssystem (2010)","van":"Frahm B, Kauling J, Pütz A, Schindler M. Begasungssystem. 2010.","ama":"Frahm B, Kauling J, Pütz A, Schindler M. Begasungssystem. 2010.","ufg":"<b>Frahm, Björn et. al. (2010)</b>: Begasungssystem.","mla":"Frahm, Björn, et al. <i>Begasungssystem</i>. 2010.","havard":"B. Frahm, J. Kauling, A. Pütz, M. Schindler, Begasungssystem, (2010).","bjps":"<b>Frahm B <i>et al.</i></b> (2010) Begasungssystem.","apa":"Frahm, B., Kauling, J., Pütz, A., &#38; Schindler, M. (2010). Begasungssystem.","ieee":"B. Frahm, J. Kauling, A. Pütz, and M. Schindler, “Begasungssystem.” 2010.","chicago":"Frahm, Björn, Jörg Kauling, Andre Pütz, and Markus Schindler. “Begasungssystem,” 2010."},"application_number":"2010000124 ","application_date":"2010-01-13","abstract":[{"lang":"ger","text":"Gegenstand der Erfindung ist ein neuartiges Begasungssystem, das insbesondere aber nicht ausschließlich in der Biotechnologie zur Versorgung von Zellen oder Mikroorganismen mit Sauerstoff einsetzbar ist. Das Begasungssystem umfasst eine Blasensäule und einen Verteiler. In dem Gefäß befindet sich ferner ein flüssiges Medium, das mit Gas versorgt werden soll. Es wird ein Vektor als Transportmittel für das Gas eingesetzt. Das Gas wird in die Blasensäule eingetragen und hier von dem Vektor aufgenommen. Der Vektor wird in Tropfenform über den Verteiler auf die Flüssigkeitsoberfläche aufgetragen, sinkt in dem Medium nach unten und gibt einen Teil des aufgenommenen Gases an das Medium ab. Am Boden des Gefäßes befindet sich eine Sammelvorrichtung, in der die Vektortropfen koaleszieren und wieder in die Blasensäule gelangen. Gegenstand der Erfindung ist weiterhin ein Bioreaktor umfassend das neuartige Begasungssystem. Gegenstand der Erfindung ist ferner ein Verfahren zur Begasung eines flüssigen Mediums, vorzugsweise einer Zellen oder Mikroorganismen enthaltenden wässrigen Suspension. "},{"text":" The invention relates to a novel gassing system that can be used particularly but not exclusively in biotechnology for supplying oxygen to cells or microorganisms. The gassing system comprises a bubble column and a distributor. There is furthermore a fluid medium in the tank that is to be supplied with gas. A vector is used as a transport means for the gas. The gas is incorporated into the bubble column and taken up by the vector here. The vector is applied to the fluid surface in droplet form via the distributor, sinks down into the medium and releases a portion of the absorbed gas to the medium. There is a collection device on the floor of the tank wherein the vector drops coalesce and enter the bubble column again. The invention furthermore relates to a bioreactor comprising the novel gassing system. The invention furthermore relates to a method for gassing a fluid medium, preferably an aqueous suspension comprising cells or microorganisms. ","lang":"eng"}],"year":2010,"author":[{"first_name":"Björn","id":"45666","full_name":"Frahm, Björn","last_name":"Frahm"},{"last_name":"Kauling","full_name":"Kauling, Jörg","first_name":"Jörg"},{"full_name":"Pütz, Andre","first_name":"Andre","last_name":"Pütz"},{"full_name":"Schindler, Markus","last_name":"Schindler","first_name":"Markus"}],"department":[{"_id":"DEP4021"}],"publication_date":"2010-07-09","status":"public","page":"35"},{"user_id":"45666","date_updated":"2023-03-15T13:49:43Z","type":"conference_speech","date_created":"2020-06-08T14:12:17Z","language":[{"iso":"eng"}],"_id":"2892","citation":{"ama":"Frahm B, Brod H. <i>Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration</i>.; 2010.","ieee":"B. Frahm and H. Brod, <i>Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration</i>. 2010.","short":"B. Frahm, H. 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Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, and S. Kirchner, “Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.” 2009.","ama":"Braun A, Brod H, Frahm B, Jenne M, Kauling J, Kirchner S. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen. 2009.","apa":"Braun, A., Brod, H., Frahm, B., Jenne, M., Kauling, J., &#38; Kirchner, S. (2009). Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.","chicago":"Braun, Arndt, Helmut Brod, Björn Frahm, Marc Jenne, Jörg Kauling, and Stephan Kirchner. “Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen,” 2009.","van":"Braun A, Brod H, Frahm B, Jenne M, Kauling J, Kirchner S. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen. 2009.","ufg":"<b>Braun, Arndt et. al. (2009)</b>: Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.","mla":"Braun, Arndt, et al. <i>Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen</i>. 2009.","bjps":"<b>Braun A <i>et al.</i></b> (2009) Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen.","havard":"A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen, (2009).","short":"A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, (2009).","chicago-de":"Braun, Arndt, Helmut Brod, Björn Frahm, Marc Jenne, Jörg Kauling und Stephan Kirchner. 2009. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Braun, Arndt</span> ; <span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Jenne, Marc</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span> ; <span style=\"font-variant:small-caps;\">Kirchner, Stephan</span>: Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen (2009)"},"application_number":"2009004200 ","extern":"1","title":"Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen","publication_date":"200-12-23","page":"35","status":"public","abstract":[{"lang":"ger","text":"Die Erfindung betrifft eine Vorrichtung und ein Verfahren zur Rückhaltung und Rückführung von Zellen in einem kontinuierlich oder absatzweise durchströmten Gefäß. Ferner betrifft die Erfindung ein Verfahren zur Herstellung einer Vorrichtung, mit dem Zellen in einem kontinuierlich oder absatzweise durchströmten Gefäß zurückgehalten und zurückgeführt werden können. "},{"text":"The invention relates to an apparatus and a method for retaining and recirculating cells in a continuous-flow or batch-flow vessel. The invention further relates to a method for producing an apparatus which allows cells to be retained and recirculated in a continuous-flow or batch-flow vessel.","lang":"eng"}],"application_date":"2009-06-10","department":[{"_id":"DEP4021"}],"author":[{"full_name":"Braun, Arndt","first_name":"Arndt","last_name":"Braun"},{"last_name":"Brod","first_name":"Helmut","full_name":"Brod, Helmut"},{"last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn","id":"45666"},{"last_name":"Jenne","first_name":"Marc","full_name":"Jenne, Marc"},{"full_name":"Kauling, Jörg","first_name":"Jörg","last_name":"Kauling"},{"full_name":"Kirchner, Stephan","last_name":"Kirchner","first_name":"Stephan"}],"year":2009},{"user_id":"45666","date_updated":"2023-03-15T13:49:43Z","date_created":"2020-06-10T14:01:21Z","type":"conference_speech","language":[{"iso":"eng"}],"_id":"2912","citation":{"chicago-de":"Frahm, Björn, H. Brod und U. 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Brod, B. Frahm, J. Kauling, R. Rose, (2007).","chicago-de":"Brod, Helmut, Björn Frahm, Jörg Kauling und Reinhold Rose. 2007. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span> ; <span style=\"font-variant:small-caps;\">Rose, Reinhold</span>: Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component (2007)","apa":"Brod, H., Frahm, B., Kauling, J., &#38; Rose, R. (2007). Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.","ieee":"H. Brod, B. Frahm, J. Kauling, and R. Rose, “Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.” 2007.","chicago":"Brod, Helmut, Björn Frahm, Jörg Kauling, and Reinhold Rose. “Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component,” 2007.","van":"Brod H, Frahm B, Kauling J, Rose R. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component. 2007.","ama":"Brod H, Frahm B, Kauling J, Rose R. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component. 2007.","ufg":"<b>Brod, Helmut et. al. (2007)</b>: Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.","bjps":"<b>Brod H <i>et al.</i></b> (2007) Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component.","havard":"H. Brod, B. Frahm, J. Kauling, R. Rose, Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component, (2007).","mla":"Brod, Helmut, et al. <i>Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component</i>. 2007."},"application_number":" \t102006008687 ","abstract":[{"text":"The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude and the equivalent number of revolutions. The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude, the equivalent number of revolutions, acceleration of the membrane surface, the delay of the membrane surface, the interruption of the movement or discontinuity. The course of motion is not restricted to recurring samples. The material transfer is increased by mounting of immovable current interfering elements. The disturb of the current forms by the rotatingly oscillating movement of the membrane surfaces. The supply of the membrane surface is undertaken with the help of flexible hoses or turning seals for the supply and discharge of gas. The membrane surface is used for the production of micro-bubbles or gas bubbles in the liquid. Rotor arms rotate in one of the rotation directions curved around the drive shaft. An independent claim is included for a device for gassing of liquid for cell cultures.  ","lang":"eng"},{"text":"Die Erfindung betrifft ein Verfahren und eine Vorrichtung zur blasenfreien Begasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. ","lang":"ger"}],"application_date":"2006-02-24","author":[{"full_name":"Brod, Helmut","first_name":"Helmut","last_name":"Brod"},{"last_name":"Frahm","id":"45666","full_name":"Frahm, Björn","first_name":"Björn"},{"last_name":"Kauling","first_name":"Jörg","full_name":"Kauling, Jörg"},{"full_name":"Rose, Reinhold","first_name":"Reinhold","last_name":"Rose"}],"year":2007,"main_file_link":[{"url":"https://depatisnet.dpma.de/DepatisNet/depatisnet?action=bibdat&docid=DE102006008687A1","open_access":"1"}],"department":[{"_id":"DEP4021"}],"publication_date":"2007-08-30","status":"public","date_created":"2020-06-05T13:41:13Z","type":"patent","user_id":"45666","date_updated":"2023-03-15T13:49:43Z","alternative_title":["Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten"],"ipc":"C12M 1/04 ","ipn":"DE102006008687A1","oa":"1","_id":"2870"},{"citation":{"ieee":"H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, and S. Schmidt, “Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.” 2007.","ama":"Brod H, Frahm B, Kauling J, Poggel M, Rose R, Schmidt S. Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. 2007.","chicago-de":"Brod, Helmut, Björn Frahm, Jörg Kauling, Martin Poggel, Reinhold Rose und Sebastian  Schmidt. 2007. Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span> ; <span style=\"font-variant:small-caps;\">Poggel, Martin</span> ; <span style=\"font-variant:small-caps;\">Rose, Reinhold</span> ; <span style=\"font-variant:small-caps;\">Schmidt, Sebastian </span>: Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen (2007)","short":"H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, S. Schmidt, (2007).","chicago":"Brod, Helmut, Björn Frahm, Jörg Kauling, Martin Poggel, Reinhold Rose, and Sebastian  Schmidt. “Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen,” 2007.","apa":"Brod, H., Frahm, B., Kauling, J., Poggel, M., Rose, R., &#38; Schmidt, S. (2007). Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.","bjps":"<b>Brod H <i>et al.</i></b> (2007) Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen.","havard":"H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, S. Schmidt, Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen, (2007).","mla":"Brod, Helmut, et al. <i>Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen</i>. 2007.","ufg":"<b>Brod, Helmut et. al. (2007)</b>: Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.","van":"Brod H, Frahm B, Kauling J, Poggel M, Rose R, Schmidt S. Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. 2007."},"application_number":"2007003521 ","extern":"1","title":"Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen","publication_date":"2007-11-01","page":"56","status":"public","application_date":"2007-04-23","abstract":[{"text":"Gegenstand der Erfindung ist ein um seine ortsfeste, bevorzugt vertikale Achse oszillatorischrotierend angetriebener Reaktor für bevorzugt biotechnologische und pharmazeutische Anwendungen. Mit seinen prozessintensivierenden Eigenschaften für das Mischen, das Suspendieren, den Gasstofftransport, die Wärmeübertragung, die Bestrahlung und die Partikelrückhaltung wird die Anwendbarkeit im großtechnischen Maßstab gewährleistet. Der ohne Wellenabdichtung auskommende Reaktor erlaubt eine steriltechnisch besonders robuste Produktion unter Verzicht auf eine Reinigung und Reinigungsvalidierung erfordert, wenn der Reaktor als Einwegreaktor ausgeführt ist. ","lang":"ger"},{"lang":"eng","text":"The subject matter of the invention is a reactor, driven about its fixed, preferably vertical, axis in an oscillatory/rotating manner, for preferably biotechnological and pharmaceutical applications. With its process-intensifying properties for mixing, suspending, gas transport, heat transfer, irradiation and particle retention, the applicability is ensured on a commercial scale. The reactor, which does not need a shaft seal, permits especially robust production with respect to sterile requirements while dispensing with cleaning and cleaning validation if the reactor is designed as a one-way reactor. "}],"department":[{"_id":"DEP4021"}],"author":[{"first_name":"Helmut","last_name":"Brod","full_name":"Brod, Helmut"},{"last_name":"Frahm","id":"45666","full_name":"Frahm, Björn","first_name":"Björn"},{"first_name":"Jörg","full_name":"Kauling, Jörg","last_name":"Kauling"},{"first_name":"Martin","full_name":"Poggel, Martin","last_name":"Poggel"},{"full_name":"Rose, Reinhold","last_name":"Rose","first_name":"Reinhold"},{"full_name":"Schmidt, Sebastian ","last_name":"Schmidt","first_name":"Sebastian "}],"year":2007,"date_updated":"2023-03-15T13:49:43Z","user_id":"45666","type":"patent","date_created":"2020-06-05T13:57:51Z","_id":"2871","alternative_title":["One-trip plastic reactor for bio-technological and pharmaceutical production applications rotates and oscillates on a vertical shaft"],"ipc":"B01J 19/28","ipn":"WO002007121958A1"},{"year":2007,"author":[{"full_name":"Brod, Helmut","last_name":"Brod","first_name":"Helmut"},{"first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm","id":"45666"},{"last_name":"Kauling","first_name":"Jörg","full_name":"Kauling, Jörg"}],"conference":{"location":"Würzburg, Germany","name":"GVC Fachausschuss Mischvorgänge","start_date":"2007-03-05","end_date":"2007-03-06"},"department":[{"_id":"DEP4021"}],"status":"public","title":"Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen","extern":"1","citation":{"van":"Brod H, Frahm B, Kauling J. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. 2007.","ama":"Brod H, Frahm B, Kauling J. <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>.; 2007.","ufg":"<b>Brod, Helmut et. al. (2007)</b>: Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen.","havard":"H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.","bjps":"<b>Brod H, Frahm B and Kauling J</b> (2007) <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>. .","mla":"Brod, Helmut, et al. <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>. 2007.","apa":"Brod, H., Frahm, B., &#38; Kauling, J. (2007). <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>. Presented at the GVC Fachausschuss Mischvorgänge, Würzburg, Germany.","ieee":"H. Brod, B. Frahm, and J. Kauling, <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>. 2007.","chicago":"Brod, Helmut, Björn Frahm, and Jörg Kauling. <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>, 2007.","short":"H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span>: <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>, 2007","chicago-de":"Brod, Helmut, Björn Frahm und Jörg Kauling. 2007. <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>."},"_id":"2909","language":[{"iso":"ger"}],"type":"conference_speech","date_created":"2020-06-10T13:47:31Z","user_id":"45666","date_updated":"2023-03-15T13:49:43Z"},{"type":"conference_speech","date_created":"2020-06-10T13:54:43Z","date_updated":"2023-03-15T13:49:43Z","user_id":"45666","language":[{"iso":"ger"}],"_id":"2910","extern":"1","title":"Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen","citation":{"ama":"Brod H, Frahm B, Kauling J. <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>.; 2007.","ieee":"H. Brod, B. Frahm, and J. Kauling, <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>. 2007.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span>: <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>, 2007","chicago-de":"Brod, Helmut, Björn Frahm und Jörg Kauling. 2007. <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>.","short":"H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.","ufg":"<b>Brod, Helmut et. al. (2007)</b>: Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen.","havard":"H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.","bjps":"<b>Brod H, Frahm B and Kauling J</b> (2007) <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>. .","mla":"Brod, Helmut, et al. <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>. 2007.","van":"Brod H, Frahm B, Kauling J. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. 2007.","chicago":"Brod, Helmut, Björn Frahm, and Jörg Kauling. <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>, 2007.","apa":"Brod, H., Frahm, B., &#38; Kauling, J. (2007). <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung „Aufarbeitung biotechnologischer Produkte\", Osnabrück, Germany."},"department":[{"_id":"DEP4021"}],"conference":{"location":"Osnabrück, Germany","name":"GVC / DECHEMA Vortrags- und Diskussionstagung „Aufarbeitung biotechnologischer Produkte\"","end_date":"2007-05-16","start_date":"2007-05-14"},"year":2007,"author":[{"last_name":"Brod","first_name":"Helmut","full_name":"Brod, Helmut"},{"id":"45666","full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn"},{"last_name":"Kauling","first_name":"Jörg","full_name":"Kauling, Jörg"}],"status":"public"},{"title":"High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)","extern":"1","citation":{"ama":"Frahm B, Kirchner S, Rose R, et al. <i>High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA)</i>.; 2007.","ieee":"B. Frahm <i>et al.</i>, <i>High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)</i>. 2007.","van":"Frahm B, Kirchner S, Rose R, Jenne M, Kauling J, Brod H, et al. High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). 2007.","mla":"Frahm, Björn, et al. <i>High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA)</i>. 2007.","bjps":"<b>Frahm B <i>et al.</i></b> (2007) <i>High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA)</i>. .","havard":"B. Frahm, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, B. Bödeker, High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA), 2007.","ufg":"<b>Frahm, Björn et. al. (2007)</b>: High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA).","apa":"Frahm, B., Kirchner, S., Rose, R., Jenne, M., Kauling, J., Brod, H., … Bödeker, B. (2007). <i>High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)</i>. Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.","chicago":"Frahm, Björn, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, and B. Bödeker. <i>High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA)</i>, 2007.","short":"B. Frahm, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, B. Bödeker, High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2007.","din1505-2-1":"<span style=\"font-variant:small-caps;\"><span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Kirchner, S.</span> ; <span style=\"font-variant:small-caps;\">Rose, R.</span> ; <span style=\"font-variant:small-caps;\">Jenne, M.</span> ; <span style=\"font-variant:small-caps;\">Kauling, J.</span> ; <span style=\"font-variant:small-caps;\">Brod, H.</span> ; <span style=\"font-variant:small-caps;\">Jöris, K.</span> ; <span style=\"font-variant:small-caps;\">Wischniewski, M.</span> ; u. a.</span>: <i>High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)</i>, 2007","chicago-de":"Frahm, Björn, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer und B. Bödeker. 2007. <i>High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)</i>."},"author":[{"id":"45666","full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn"},{"full_name":"Kirchner, S.","first_name":"S.","last_name":"Kirchner"},{"last_name":"Rose","first_name":"R.","full_name":"Rose, R."},{"full_name":"Jenne, M.","first_name":"M.","last_name":"Jenne"},{"first_name":"J.","full_name":"Kauling, J.","last_name":"Kauling"},{"last_name":"Brod","full_name":"Brod, H.","first_name":"H."},{"full_name":"Jöris, K.","first_name":"K.","last_name":"Jöris"},{"last_name":"Wischniewski","full_name":"Wischniewski, M.","first_name":"M."},{"last_name":"Langer","full_name":"Langer, U.","first_name":"U."},{"first_name":"B.","last_name":"Bödeker","full_name":"Bödeker, B."}],"year":2007,"department":[{"_id":"DEP4021"}],"conference":{"start_date":"2007-12-07","location":"Leverkusen, Germany","name":"Technology Colloquium, BayKomm"},"status":"public","date_created":"2020-06-18T14:11:22Z","type":"conference_poster","user_id":"45666","date_updated":"2023-03-15T13:49:44Z","language":[{"iso":"eng"}],"_id":"2967"},{"citation":{"short":"B. 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Frahm, P. Lane, H. Märkl, R. Pörtner, Bioprocess and Biosystems Engineering 26 (2003) 1–10.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Lane, P.</span> ; <span style=\"font-variant:small-caps;\">Märkl, H.</span> ; <span style=\"font-variant:small-caps;\">Pörtner, R.</span>: Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. In: <i>Bioprocess and Biosystems Engineering</i> Bd. 26, Springer (2003), Nr. 1, S. 1–10","chicago-de":"Frahm, Björn, P. Lane, H. Märkl und R. Pörtner. 2003. Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. <i>Bioprocess and Biosystems Engineering</i> 26, Nr. 1: 1–10. doi:<a href=\"https://doi.org/10.1007/s00449-003-0335-z,\">10.1007/s00449-003-0335-z,</a> .","ama":"Frahm B, Lane P, Märkl H, Pörtner R. 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Für die verbesserte Steuerung von derartigen Fed-Batch-Prozessen stellt der Autor eine adaptive, modellgestützte Steuerung vor. Anwendungsbeispiele veranschaulichen das Potential und die Flexibilität der Steuerung und ihre Universalität bezüglich verschiedener Kultivierungssysteme und Zelllinien. \r\n\r\nDa auch die gelöst-CO2-Konzentration und die Atmungsaktivität der Zellen zunehmend Bedeutung in der Prozessführung erlangen, stellt dieses Buch weiterhin die entwickelte Erfassung dieser Größen per Abgasanalytik und Modellierung des Kohlendioxidtransfers vor."}],"department":[{"_id":"DEP4021"}],"author":[{"full_name":"Frahm, Björn","id":"45666","last_name":"Frahm","first_name":"Björn"}],"year":2003,"publisher":"Books on Demand GmbH","page":"120","status":"public","title":"Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen","publication_status":"published","citation":{"mla":"Frahm, Björn. <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Books on Demand GmbH, 2003.","havard":"B. 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Norderstedt: Books on Demand GmbH, 2003.","apa":"Frahm, B. (2003). <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH.","chicago-de":"Frahm, Björn. 2003. <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt : Books on Demand GmbH, 2003","short":"B. 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Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. Beckmann D, Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld), editors. Technische Systeme für Biotechnologie und Umwelt. Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik ; 2003.","ufg":"<b>Frahm, Björn et. al. (2003)</b>: Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control, Heiligenstadt.","havard":"B. Frahm, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V.C. Hass, R. 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Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik .","din1505-2-1":"<span style=\"font-variant:small-caps;\"><span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Müller-Landré, B.</span> ; <span style=\"font-variant:small-caps;\">Wiggers de Almeida, G.</span> ; <span style=\"font-variant:small-caps;\">Singer, M.</span> ; <span style=\"font-variant:small-caps;\">Rausch, M.</span> ; <span style=\"font-variant:small-caps;\">Lane, P.</span> ; <span style=\"font-variant:small-caps;\">Munack, A.</span> ; <span style=\"font-variant:small-caps;\">Hass, V. C.</span> ; u. a.</span> ; <span style=\"font-variant:small-caps;\">Beckmann, D.</span> ; <span style=\"font-variant:small-caps;\">Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld)</span> (Hrsg.): <i>Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control</i>. 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Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik , 2003, pp. 503–509."},"extern":"1","title":"Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control","language":[{"iso":"eng"}],"place":"Heiligenstadt","_id":"2435","date_updated":"2023-03-15T13:49:40Z","user_id":"45666","editor":[{"last_name":"Beckmann","full_name":"Beckmann, Dieter","first_name":"Dieter"}],"corporate_editor":["Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld)","Institut für Bioprozeß- und Analysenmeßtechnik "],"type":"conference_editor_article","date_created":"2020-05-20T13:59:48Z","publication":"Technische Systeme für Biotechnologie und Umwelt","publication_identifier":{"isbn":["3-00-011287-1"]}},{"status":"public","publisher":"ECCE4","department":[{"_id":"DEP4021"}],"conference":{"end_date":"2003-09-25","start_date":"2003-09-21","location":"Granada","name":"4th European Congress of Chemical Engineering"},"year":2003,"author":[{"full_name":"Kühn, K.","last_name":"Kühn","first_name":"K."},{"full_name":"Frahm, Björn","first_name":"Björn","id":"45666","last_name":"Frahm"},{"full_name":"Pörtner, R.","last_name":"Pörtner","first_name":"R."},{"last_name":"Lane","first_name":"P.","full_name":"Lane, P."},{"full_name":"Munack, A.","last_name":"Munack","first_name":"A."},{"full_name":"Hass, V. C.","first_name":"V. C.","last_name":"Hass"}],"publication_status":"published","citation":{"chicago-de":"Kühn, K., Björn Frahm, R. Pörtner, P. Lane, A. Munack und V. C. Hass. 2003. <i>Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells</i>. Hg. von European Federation of Chemical Engineering. <i> ECCE - 4th European Congress of Chemical Engineering</i>. Bd. 10. Granada: ECCE4.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kühn, K.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Pörtner, R.</span> ; <span style=\"font-variant:small-caps;\">Lane, P.</span> ; <span style=\"font-variant:small-caps;\">Munack, A.</span> ; <span style=\"font-variant:small-caps;\">Hass, V. C.</span> ; <span style=\"font-variant:small-caps;\">European Federation of Chemical Engineering</span> (Hrsg.): <i>Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells</i>. Bd. 10. Granada : ECCE4, 2003","short":"K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. Hass, Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, ECCE4, Granada, 2003.","chicago":"Kühn, K., Björn Frahm, R. Pörtner, P. Lane, A. Munack, and V. C. Hass. <i>Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells</i>. Edited by European Federation of Chemical Engineering. <i> ECCE - 4th European Congress of Chemical Engineering</i>. Vol. 10. Granada: ECCE4, 2003.","apa":"Kühn, K., Frahm, B., Pörtner, R., Lane, P., Munack, A., &#38; Hass, V. C. (2003). <i>Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells</i>. (European Federation of Chemical Engineering, Ed.), <i> ECCE - 4th European Congress of Chemical Engineering</i> (Vol. 10). Granada: ECCE4.","ufg":"<b>Kühn, K. et. al. (2003)</b>: Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells (=<i> 10</i>), Granada.","havard":"K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. 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Oxford: ScienceDirect. doi:<a href=\"https://doi.org/10.1016/S1474-6670(17)34240-4,\">https://doi.org/10.1016/S1474-6670(17)34240-4,</a> .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hass, V.C.</span> ; <span style=\"font-variant:small-caps;\">Lane, P.</span> ; <span style=\"font-variant:small-caps;\">Hoffmann, M.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Schwabe, J.-O.</span> ; <span style=\"font-variant:small-caps;\">Pörtner, R.</span> ; <span style=\"font-variant:small-caps;\">Munack, A.</span> ; <span style=\"font-variant:small-caps;\">Published for the International Federation of Automatic Control by Pergamon </span> (Hrsg.): <i>Model-Based Control of Hybridoma Cell Cultures</i>, <i>  IFAC Proceedings Volumes / IFAC, International Federation of Automatic Control</i>. Bd. 34. 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