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(2011)</b>: Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor.","bjps":"<b>Van Hecke W <i>et al.</i></b> (2011) <i>Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor</i>. .","chicago-de":"Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod und R. Ludwig. 2011. <i>Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor</i>.","ama":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. <i>Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor</i>.; 2011.","short":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, 2011.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Van Hecke, W.</span> ; <span style=\"font-variant:small-caps;\">Haltrich, D.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Brod, H.</span> ; <span style=\"font-variant:small-caps;\">Ludwig, R.</span>: <i>Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor</i>, 2011","apa":"Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., &#38; Ludwig, R. (2011). <i>Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor</i>. Presented at the 1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting, Berlin, Germany.","van":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. 2011.","ieee":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, and R. Ludwig, <i>Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor</i>. 2011.","mla":"Van Hecke, W., et al. <i>Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor</i>. 2011.","chicago":"Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod, and R. Ludwig. <i>Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor</i>, 2011."},"conference":{"start_date":"2011-09-25","location":"Berlin, Germany","name":"1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting","end_date":"2011-09-29"},"year":2011,"title":"Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor","department":[{"_id":"DEP4021"}],"date_created":"2020-06-18T14:28:39Z","date_updated":"2023-03-15T13:49:44Z","user_id":"45666"},{"date_created":"2020-06-04T13:18:51Z","department":[{"_id":"DEP4021"}],"date_updated":"2023-03-15T13:49:43Z","user_id":"45666","title":"Intensified absorption and distillation devices for modular chemical production processes","publication_identifier":{"isbn":["978-80-02-02250-3","978-80-02-02210-7 (CD-ROM)"]},"year":2010,"type":"conference_editor_article","citation":{"mla":"Dercks, B., et al. “Intensified Absorption and Distillation Devices for Modular Chemical Production Processes.” <i>Proceedings 19th International Congress of Chemical and Process Engineering</i>, Czech Society of Chemical Engineering, 2010.","chicago":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P.  Schmidt, D. Sudhoff, S. Ressler, and R. Zecirovic. <i>Intensified Absorption and Distillation Devices for Modular Chemical Production Processes</i>. <i>Proceedings 19th International Congress of Chemical and Process Engineering</i>. Czech Society of Chemical Engineering, 2010.","ama":"Dercks B, Frahm B, Grünewald M, et al. <i>Intensified Absorption and Distillation Devices for Modular Chemical Production Processes</i>. Czech Society of Chemical Engineering; 2010.","van":"Dercks B, Frahm B, Grünewald M, Kenig E, Lautenschleger A, Gorak A, et al. Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering; 2010.","ieee":"B. Dercks <i>et al.</i>, <i>Intensified absorption and distillation devices for modular chemical production processes</i>. Czech Society of Chemical Engineering, 2010.","short":"B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, Czech Society of Chemical Engineering, 2010.","havard":"B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified absorption and distillation devices for modular chemical production processes, Czech Society of Chemical Engineering, 2010.","din1505-2-1":"<span style=\"font-variant:small-caps;\"><span style=\"font-variant:small-caps;\">Dercks, B.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Grünewald, M.</span> ; <span style=\"font-variant:small-caps;\">Kenig, E.</span> ; <span style=\"font-variant:small-caps;\">Lautenschleger, A.</span> ; <span style=\"font-variant:small-caps;\">Gorak, A.</span> ; <span style=\"font-variant:small-caps;\">Schmidt, P. </span> ; <span style=\"font-variant:small-caps;\">Sudhoff, D.</span> ; u. a.</span>: <i>Intensified absorption and distillation devices for modular chemical production processes</i> : Czech Society of Chemical Engineering, 2010","chicago-de":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P.  Schmidt, D. Sudhoff, S. Ressler und R. Zecirovic. 2010. <i>Intensified absorption and distillation devices for modular chemical production processes</i>. <i>Proceedings 19th International Congress of Chemical and Process Engineering</i>. Czech Society of Chemical Engineering.","ufg":"<b>Dercks, B. et. al. (2010)</b>: Intensified absorption and distillation devices for modular chemical production processes.","bjps":"<b>Dercks B <i>et al.</i></b> (2010) <i>Intensified Absorption and Distillation Devices for Modular Chemical Production Processes</i>. Czech Society of Chemical Engineering.","apa":"Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). <i>Intensified absorption and distillation devices for modular chemical production processes</i>. <i>Proceedings 19th International Congress of Chemical and Process Engineering</i>. Prague, CZ: Czech Society of Chemical Engineering."},"conference":{"start_date":"2010-08-28","location":"Prague, CZ","name":"7th European Congress of Chemical Engineering ; 19th International Congress of Chemical and Process Engineering","end_date":"2010-09-01"},"author":[{"first_name":"B.","full_name":"Dercks, B.","last_name":"Dercks"},{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"last_name":"Grünewald","full_name":"Grünewald, M.","first_name":"M."},{"last_name":"Kenig","full_name":"Kenig, E.","first_name":"E."},{"last_name":"Lautenschleger","first_name":"A.","full_name":"Lautenschleger, A."},{"full_name":"Gorak, A.","first_name":"A.","last_name":"Gorak"},{"last_name":"Schmidt","full_name":"Schmidt, P. ","first_name":"P. "},{"first_name":"D.","full_name":"Sudhoff, D.","last_name":"Sudhoff"},{"last_name":"Ressler","full_name":"Ressler, S.","first_name":"S."},{"full_name":"Zecirovic, R.","first_name":"R.","last_name":"Zecirovic"}],"publisher":"Czech Society of Chemical Engineering","_id":"2815","language":[{"iso":"eng"}],"extern":"1","publication_status":"published","status":"public","publication":"Proceedings 19th International Congress of Chemical and Process Engineering"},{"department":[{"_id":"DEP4021"}],"date_created":"2020-06-05T14:12:21Z","date_updated":"2023-03-15T13:49:43Z","application_number":"2009006722 ","user_id":"45666","alternative_title":["Method for reducing deposits during the cultivation of organisms"],"application_date":"2009-09-17","publication_date":"2010-04-01","title":"Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen","year":2010,"citation":{"bjps":"<b>Brod H, Frahm B and Kauling J</b> (2010) Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen.","chicago-de":"Brod, Helmut, Björn Frahm und Jörg Kauling. 2010. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","ufg":"<b>Brod, Helmut et. al. (2010)</b>: Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","havard":"H. Brod, B. Frahm, J. Kauling, Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen, (2010).","short":"H. Brod, B. Frahm, J. Kauling, (2010).","ama":"Brod H, Frahm B, Kauling J. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen. 2010.","apa":"Brod, H., Frahm, B., &#38; Kauling, J. (2010). Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span>: Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen (2010)","mla":"Brod, Helmut, et al. <i>Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen</i>. 2010.","chicago":"Brod, Helmut, Björn Frahm, and Jörg Kauling. “Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen,” 2010.","van":"Brod H, Frahm B, Kauling J. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen. 2010.","ieee":"H. Brod, B. Frahm, and J. Kauling, “Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.” 2010."},"type":"patent","ipc":"C12N 5/00","ipn":"WO002010034428A2","author":[{"last_name":"Brod","full_name":"Brod, Helmut","first_name":"Helmut"},{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"last_name":"Kauling","full_name":"Kauling, Jörg","first_name":"Jörg"}],"_id":"2873","abstract":[{"text":"Die Erfindung betrifft ein Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen, insbesondere von Zellkulturen, welche zur Agglomeration bzw. Anhaftung an den Bioreaktor und seine Elemente neigen, oder bei denen Zelldebris oder Substanzen leicht agglomerieren bzw. anhaften.","lang":"ger"},{"lang":"eng","text":"The invention relates to a method for reducing deposits during the cultivation of organisms, particularly cell cultures, which tend to agglomerate or adhere to the bioreactor and the elements thereof, or in which cell debris or substances easily agglomerate or adhere. "}],"extern":"1","page":"26","status":"public"},{"ipn":"WO002010069492A1","citation":{"havard":"H. Brod, B. Frahm, M. Jenne, J. Kauling, Bioreaktor, (2010).","chicago-de":"Brod, Helmut, Björn Frahm, Marc Jenne und Jörg Kauling. 2010. Bioreaktor.","bjps":"<b>Brod H <i>et al.</i></b> (2010) Bioreaktor.","ufg":"<b>Brod, Helmut et. al. (2010)</b>: Bioreaktor.","ama":"Brod H, Frahm B, Jenne M, Kauling J. Bioreaktor. 2010.","short":"H. Brod, B. Frahm, M. Jenne, J. Kauling, (2010).","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Jenne, Marc</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span>: Bioreaktor (2010)","apa":"Brod, H., Frahm, B., Jenne, M., &#38; Kauling, J. (2010). Bioreaktor.","van":"Brod H, Frahm B, Jenne M, Kauling J. Bioreaktor. 2010.","ieee":"H. Brod, B. Frahm, M. Jenne, and J. Kauling, “Bioreaktor.” 2010.","mla":"Brod, Helmut, et al. <i>Bioreaktor</i>. 2010.","chicago":"Brod, Helmut, Björn Frahm, Marc Jenne, and Jörg Kauling. “Bioreaktor,” 2010."},"type":"patent","ipc":"C12M 1/04","year":2010,"title":"Bioreaktor","publication_date":"2010-06-24","user_id":"45666","application_date":"2009-12-08","alternative_title":["Mikrogespargter Air-Lift-Bioreaktor für die Zellkultur"],"department":[{"_id":"DEP4021"}],"date_created":"2020-06-05T14:17:50Z","date_updated":"2023-03-15T13:49:43Z","application_number":"2009008733 ","page":"27","status":"public","extern":"1","_id":"2874","abstract":[{"text":"Die Erfindung betrifft einen Bioreaktor, die Verwendung des Bioreaktors zur Kultivierung von Mikroorganismen oder Zellkulturen sowie ein Verfahren zur Kultivierung von Mikroorganismen oder Zellkulturen. ","lang":"ger"},{"lang":"eng","text":"The invention relates to a bioreactor, to the use of the bioreactor for culturing microorganisms or cell cultures, and also to a method for culturing microorganisms or cell cultures. "}],"author":[{"last_name":"Brod","full_name":"Brod, Helmut","first_name":"Helmut"},{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"last_name":"Jenne","full_name":"Jenne, Marc","first_name":"Marc"},{"first_name":"Jörg","full_name":"Kauling, Jörg","last_name":"Kauling"}]},{"abstract":[{"lang":"ger","text":"Gegenstand der Erfindung ist ein neuartiges Begasungssystem, das insbesondere aber nicht ausschließlich in der Biotechnologie zur Versorgung von Zellen oder Mikroorganismen mit Sauerstoff einsetzbar ist. Das Begasungssystem umfasst eine Blasensäule und einen Verteiler. In dem Gefäß befindet sich ferner ein flüssiges Medium, das mit Gas versorgt werden soll. Es wird ein Vektor als Transportmittel für das Gas eingesetzt. Das Gas wird in die Blasensäule eingetragen und hier von dem Vektor aufgenommen. Der Vektor wird in Tropfenform über den Verteiler auf die Flüssigkeitsoberfläche aufgetragen, sinkt in dem Medium nach unten und gibt einen Teil des aufgenommenen Gases an das Medium ab. Am Boden des Gefäßes befindet sich eine Sammelvorrichtung, in der die Vektortropfen koaleszieren und wieder in die Blasensäule gelangen. Gegenstand der Erfindung ist weiterhin ein Bioreaktor umfassend das neuartige Begasungssystem. Gegenstand der Erfindung ist ferner ein Verfahren zur Begasung eines flüssigen Mediums, vorzugsweise einer Zellen oder Mikroorganismen enthaltenden wässrigen Suspension. "},{"lang":"eng","text":" The invention relates to a novel gassing system that can be used particularly but not exclusively in biotechnology for supplying oxygen to cells or microorganisms. The gassing system comprises a bubble column and a distributor. There is furthermore a fluid medium in the tank that is to be supplied with gas. A vector is used as a transport means for the gas. The gas is incorporated into the bubble column and taken up by the vector here. The vector is applied to the fluid surface in droplet form via the distributor, sinks down into the medium and releases a portion of the absorbed gas to the medium. There is a collection device on the floor of the tank wherein the vector drops coalesce and enter the bubble column again. The invention furthermore relates to a bioreactor comprising the novel gassing system. The invention furthermore relates to a method for gassing a fluid medium, preferably an aqueous suspension comprising cells or microorganisms. "}],"_id":"2875","extern":"1","author":[{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"last_name":"Kauling","full_name":"Kauling, Jörg","first_name":"Jörg"},{"first_name":"Andre","full_name":"Pütz, Andre","last_name":"Pütz"},{"full_name":"Schindler, Markus","first_name":"Markus","last_name":"Schindler"}],"status":"public","page":"35","publication_date":"2010-07-09","title":"Begasungssystem","application_number":"2010000124 ","date_updated":"2023-03-15T13:49:43Z","date_created":"2020-06-05T14:22:30Z","department":[{"_id":"DEP4021"}],"alternative_title":["Gassing System"],"application_date":"2010-01-13","user_id":"45666","ipc":"C12M 1/04 ","citation":{"havard":"B. Frahm, J. Kauling, A. Pütz, M. Schindler, Begasungssystem, (2010).","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span> ; <span style=\"font-variant:small-caps;\">Pütz, Andre</span> ; <span style=\"font-variant:small-caps;\">Schindler, Markus</span>: Begasungssystem (2010)","ufg":"<b>Frahm, Björn et. al. (2010)</b>: Begasungssystem.","bjps":"<b>Frahm B <i>et al.</i></b> (2010) Begasungssystem.","chicago-de":"Frahm, Björn, Jörg Kauling, Andre Pütz und Markus Schindler. 2010. Begasungssystem.","apa":"Frahm, B., Kauling, J., Pütz, A., &#38; Schindler, M. (2010). Begasungssystem.","chicago":"Frahm, Björn, Jörg Kauling, Andre Pütz, and Markus Schindler. “Begasungssystem,” 2010.","mla":"Frahm, Björn, et al. <i>Begasungssystem</i>. 2010.","ama":"Frahm B, Kauling J, Pütz A, Schindler M. Begasungssystem. 2010.","van":"Frahm B, Kauling J, Pütz A, Schindler M. Begasungssystem. 2010.","ieee":"B. Frahm, J. Kauling, A. Pütz, and M. Schindler, “Begasungssystem.” 2010.","short":"B. Frahm, J. Kauling, A. Pütz, M. Schindler, (2010)."},"type":"patent","ipn":"WO002010083956A2","year":2010},{"_id":"2892","language":[{"iso":"eng"}],"publication_status":"published","extern":"1","author":[{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"last_name":"Brod","full_name":"Brod, Helmut","first_name":"Helmut"}],"status":"public","title":"Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration","date_updated":"2023-03-15T13:49:43Z","department":[{"_id":"DEP4021"}],"date_created":"2020-06-08T14:12:17Z","user_id":"45666","citation":{"chicago-de":"Frahm, Björn und Helmut Brod. 2010. <i>Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration</i>.","ufg":"<b>Frahm, Björn/Brod, Helmut (2010)</b>: Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration.","bjps":"<b>Frahm B and Brod H</b> (2010) <i>Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration</i>. .","apa":"Frahm, B., &#38; Brod, H. 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Brod, Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration, 2010.","mla":"Frahm, Björn, and Helmut Brod. <i>Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration</i>. 2010.","chicago":"Frahm, Björn, and Helmut Brod. <i>Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration</i>, 2010.","ama":"Frahm B, Brod H. <i>Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration</i>.; 2010.","van":"Frahm B, Brod H. Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration. 2010.","ieee":"B. Frahm and H. Brod, <i>Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration</i>. 2010."},"type":"conference_speech","conference":{"location":"Boston, USA","start_date":"2010-08-23","end_date":"2010-08-24","name":"6th annual Optimizing Cell Culture Technology-Meeting as part of The Bioprocessing Summit - Practical Solutions for Today’s Laboratory Challenges"},"year":2010},{"user_id":"45666","date_updated":"2023-03-15T13:49:43Z","department":[{"_id":"DEP4021"}],"date_created":"2020-06-10T14:06:06Z","title":"Intensified absorption and distillation devices for modular chemical production processes","year":2010,"conference":{"start_date":"2010-08-28","location":"Prague, Czech Republic","name":"19th International Congress of Chemical and Process Engineering, CHISA ","end_date":"2010-09-01"},"citation":{"bjps":"<b>Dercks B <i>et al.</i></b> (2010) <i>Intensified Absorption and Distillation Devices for Modular Chemical Production Processes</i>. .","chicago-de":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler und R. Zecirovic. 2010. <i>Intensified absorption and distillation devices for modular chemical production processes</i>.","ufg":"<b>Dercks, B. et. al. (2010)</b>: Intensified absorption and distillation devices for modular chemical production processes.","havard":"B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified absorption and distillation devices for modular chemical production processes, 2010.","short":"B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. 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Presented at the 19th International Congress of Chemical and Process Engineering, CHISA , Prague, Czech Republic.","din1505-2-1":"<span style=\"font-variant:small-caps;\"><span style=\"font-variant:small-caps;\">Dercks, B.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Grünewald, M.</span> ; <span style=\"font-variant:small-caps;\">Kenig, E.</span> ; <span style=\"font-variant:small-caps;\">Lautenschleger, A.</span> ; <span style=\"font-variant:small-caps;\">Gorak, A.</span> ; <span style=\"font-variant:small-caps;\">Schmidt, P.</span> ; <span style=\"font-variant:small-caps;\">Sudhoff, D.</span> ; u. a.</span>: <i>Intensified absorption and distillation devices for modular chemical production processes</i>, 2010","chicago":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, and R. 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Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology. 2009;59(1):17–30.","ieee":"B. Frahm, H. Brod, and U. Langer, “Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration,” <i>Cytotechnology</i>, vol. 59, no. 1, pp. 17–30, 2009.","havard":"B. Frahm, H. Brod, U. Langer, Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration, Cytotechnology. 59 (2009) 17–30.","chicago-de":"Frahm, Björn, Helmut Brod und Uwe Langer. 2009. Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. <i>Cytotechnology</i> 59, Nr. 1: 17–30. doi:<a href=\"https://doi.org/10.1007/s10616-009-9189-9,\">10.1007/s10616-009-9189-9,</a> .","ufg":"<b>Frahm, Björn et. al. (2009)</b>: Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration, in: <i>Cytotechnology</i> <i>59</i> (<i>1</i>), S. 17–30.","bjps":"<b>Frahm B, Brod H and Langer U</b> (2009) Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration. <i>Cytotechnology</i> <b>59</b>, 17–30.","ama":"Frahm B, Brod H, Langer U. Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. <i>Cytotechnology</i>. 2009;59(1):17-30. doi:<a href=\"https://doi.org/10.1007/s10616-009-9189-9\">10.1007/s10616-009-9189-9</a>","short":"B. Frahm, H. Brod, U. Langer, Cytotechnology 59 (2009) 17–30."},"year":2009,"publication_status":"published","publisher":"Springer","author":[{"id":"45666","last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn"},{"first_name":"Helmut","full_name":"Brod, Helmut","last_name":"Brod"},{"first_name":"Uwe","full_name":"Langer, Uwe","last_name":"Langer"}],"publication":"Cytotechnology","issue":"1","status":"public","title":"Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration","volume":59,"intvolume":"        59","publication_identifier":{"eissn":["1573-0778"],"issn":["0920-9069"]}},{"year":2009,"ipc":"C12M 1/08","citation":{"ama":"Braun A, Brod H, Frahm B, Jenne M, Kauling J, Kirchner S. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen. 2009.","short":"A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, (2009).","havard":"A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen, (2009).","bjps":"<b>Braun A <i>et al.</i></b> (2009) Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen.","ufg":"<b>Braun, Arndt et. al. (2009)</b>: Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.","chicago-de":"Braun, Arndt, Helmut Brod, Björn Frahm, Marc Jenne, Jörg Kauling und Stephan Kirchner. 2009. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.","ieee":"A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, and S. Kirchner, “Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.” 2009.","van":"Braun A, Brod H, Frahm B, Jenne M, Kauling J, Kirchner S. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen. 2009.","chicago":"Braun, Arndt, Helmut Brod, Björn Frahm, Marc Jenne, Jörg Kauling, and Stephan Kirchner. “Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen,” 2009.","mla":"Braun, Arndt, et al. <i>Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen</i>. 2009.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Braun, Arndt</span> ; <span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Jenne, Marc</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span> ; <span style=\"font-variant:small-caps;\">Kirchner, Stephan</span>: Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen (2009)","apa":"Braun, A., Brod, H., Frahm, B., Jenne, M., Kauling, J., &#38; Kirchner, S. (2009). Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen."},"type":"patent","ipn":"WO002009152990A2 ","date_updated":"2023-03-15T13:49:43Z","application_number":"2009004200 ","date_created":"2020-06-05T14:07:35Z","department":[{"_id":"DEP4021"}],"application_date":"2009-06-10","alternative_title":["Device for retaining and recirculating cells in a continuous-flow or batch-flow vessel, comprises channels, means for fumigation of external surfaces and/or spaces between the channels, and a generating mean"],"user_id":"45666","publication_date":"200-12-23","title":"Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen","status":"public","page":"35","author":[{"last_name":"Braun","full_name":"Braun, Arndt","first_name":"Arndt"},{"full_name":"Brod, Helmut","first_name":"Helmut","last_name":"Brod"},{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"last_name":"Jenne","first_name":"Marc","full_name":"Jenne, Marc"},{"first_name":"Jörg","full_name":"Kauling, Jörg","last_name":"Kauling"},{"first_name":"Stephan","full_name":"Kirchner, Stephan","last_name":"Kirchner"}],"_id":"2872","abstract":[{"lang":"ger","text":"Die Erfindung betrifft eine Vorrichtung und ein Verfahren zur Rückhaltung und Rückführung von Zellen in einem kontinuierlich oder absatzweise durchströmten Gefäß. Ferner betrifft die Erfindung ein Verfahren zur Herstellung einer Vorrichtung, mit dem Zellen in einem kontinuierlich oder absatzweise durchströmten Gefäß zurückgehalten und zurückgeführt werden können. "},{"text":"The invention relates to an apparatus and a method for retaining and recirculating cells in a continuous-flow or batch-flow vessel. The invention further relates to a method for producing an apparatus which allows cells to be retained and recirculated in a continuous-flow or batch-flow vessel.","lang":"eng"}],"extern":"1"},{"user_id":"45666","date_created":"2020-06-10T14:01:21Z","department":[{"_id":"DEP4021"}],"date_updated":"2023-03-15T13:49:43Z","title":"Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)","year":2009,"conference":{"name":"Industrial Biotechnology Exhibition & Partnering Conference at ACHEMA ","end_date":"2009-05-15","start_date":"2009-05-11","location":"Frankfurt am Main, Germany"},"citation":{"chicago":"Frahm, Björn, H. 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(2009)</b>: Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA).","bjps":"<b>Frahm B, Brod H and Langer U</b> (2009) <i>Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA)</i>. .","havard":"B. Frahm, H. Brod, U. 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Pörtner, B. Frahm, P. Lane, A. Munack, K. Kühn, and V. C. Hass, <i>Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller</i>, vol. 3. Dordrecht: Springer, 2007, pp. 497–501.","van":"Pörtner R, Frahm B, Lane P, Munack A, Kühn K, Hass VC. Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller. Cell Technology for Cell Products. Dordrecht: Springer; 2007. (ESACT Proceedings; vol. 3).","ama":"Pörtner R, Frahm B, Lane P, Munack A, Kühn K, Hass VC. <i>Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller</i>. Vol 3. 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(2007). <i>Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller</i>. <i>Cell Technology for Cell Products</i> (Vol. 3, pp. 497–501). Dordrecht: Springer. <a href=\"https://doi.org/10.1007/978-1-4020-5476-1_84\">https://doi.org/10.1007/978-1-4020-5476-1_84</a>","ufg":"<b>Pörtner, Ralf et. al. (2007)</b>: Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller (=<i>ESACT Proceedings 3</i>), Dordrecht.","chicago-de":"Pörtner, Ralf, Björn Frahm, Paul Lane, Axel Munack, Kathrin Kühn und Volker C. Hass. 2007. <i>Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller</i>. <i>Cell Technology for Cell Products</i>. Bd. 3. ESACT Proceedings. Dordrecht: Springer. doi:<a href=\"https://doi.org/10.1007/978-1-4020-5476-1_84,\">10.1007/978-1-4020-5476-1_84,</a> .","bjps":"<b>Pörtner R <i>et al.</i></b> (2007) <i>Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller</i>. Dordrecht: Springer."},"type":"conference_editor_article","conference":{"name":"19th ESACT Meeting","end_date":"2005-06-08","start_date":"2005-06-05","location":"Harrogate, UK"}},{"status":"public","author":[{"last_name":"Brod","full_name":"Brod, Helmut","first_name":"Helmut"},{"last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn","id":"45666"},{"first_name":"Jörg","full_name":"Kauling, Jörg","last_name":"Kauling"},{"first_name":"Reinhold","full_name":"Rose, Reinhold","last_name":"Rose"}],"abstract":[{"text":"The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude and the equivalent number of revolutions. The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude, the equivalent number of revolutions, acceleration of the membrane surface, the delay of the membrane surface, the interruption of the movement or discontinuity. The course of motion is not restricted to recurring samples. The material transfer is increased by mounting of immovable current interfering elements. The disturb of the current forms by the rotatingly oscillating movement of the membrane surfaces. The supply of the membrane surface is undertaken with the help of flexible hoses or turning seals for the supply and discharge of gas. The membrane surface is used for the production of micro-bubbles or gas bubbles in the liquid. Rotor arms rotate in one of the rotation directions curved around the drive shaft. An independent claim is included for a device for gassing of liquid for cell cultures.  ","lang":"eng"},{"lang":"ger","text":"Die Erfindung betrifft ein Verfahren und eine Vorrichtung zur blasenfreien Begasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. "}],"ipc":"C12M 1/04 ","ipn":"DE102006008687A1","application_date":"2006-02-24","title":"Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component","_id":"2870","extern":"1","year":2007,"oa":"1","citation":{"apa":"Brod, H., Frahm, B., Kauling, J., &#38; Rose, R. (2007). Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span> ; <span style=\"font-variant:small-caps;\">Rose, Reinhold</span>: Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component (2007)","van":"Brod H, Frahm B, Kauling J, Rose R. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component. 2007.","ieee":"H. Brod, B. Frahm, J. Kauling, and R. Rose, “Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.” 2007.","mla":"Brod, Helmut, et al. <i>Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component</i>. 2007.","chicago":"Brod, Helmut, Björn Frahm, Jörg Kauling, and Reinhold Rose. “Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component,” 2007.","chicago-de":"Brod, Helmut, Björn Frahm, Jörg Kauling und Reinhold Rose. 2007. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.","ufg":"<b>Brod, Helmut et. al. (2007)</b>: Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.","bjps":"<b>Brod H <i>et al.</i></b> (2007) Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component.","havard":"H. Brod, B. Frahm, J. Kauling, R. Rose, Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component, (2007).","short":"H. Brod, B. Frahm, J. Kauling, R. Rose, (2007).","ama":"Brod H, Frahm B, Kauling J, Rose R. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component. 2007."},"type":"patent","main_file_link":[{"url":"https://depatisnet.dpma.de/DepatisNet/depatisnet?action=bibdat&docid=DE102006008687A1","open_access":"1"}],"date_updated":"2023-03-15T13:49:43Z","application_number":" \t102006008687 ","date_created":"2020-06-05T13:41:13Z","department":[{"_id":"DEP4021"}],"alternative_title":["Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten"],"user_id":"45666","publication_date":"2007-08-30"},{"title":"Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen","publication_date":"2007-11-01","date_created":"2020-06-05T13:57:51Z","department":[{"_id":"DEP4021"}],"application_number":"2007003521 ","date_updated":"2023-03-15T13:49:43Z","user_id":"45666","alternative_title":["One-trip plastic reactor for bio-technological and pharmaceutical production applications rotates and oscillates on a vertical shaft"],"application_date":"2007-04-23","citation":{"havard":"H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, S. Schmidt, Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen, (2007).","din1505-2-1":"<span style=\"font-variant:small-caps;\">Brod, Helmut</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Kauling, Jörg</span> ; <span style=\"font-variant:small-caps;\">Poggel, Martin</span> ; <span style=\"font-variant:small-caps;\">Rose, Reinhold</span> ; <span style=\"font-variant:small-caps;\">Schmidt, Sebastian </span>: Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen (2007)","bjps":"<b>Brod H <i>et al.</i></b> (2007) Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen.","chicago-de":"Brod, Helmut, Björn Frahm, Jörg Kauling, Martin Poggel, Reinhold Rose und Sebastian  Schmidt. 2007. Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.","ufg":"<b>Brod, Helmut et. al. (2007)</b>: Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.","apa":"Brod, H., Frahm, B., Kauling, J., Poggel, M., Rose, R., &#38; Schmidt, S. (2007). Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.","ama":"Brod H, Frahm B, Kauling J, Poggel M, Rose R, Schmidt S. Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. 2007.","mla":"Brod, Helmut, et al. <i>Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen</i>. 2007.","chicago":"Brod, Helmut, Björn Frahm, Jörg Kauling, Martin Poggel, Reinhold Rose, and Sebastian  Schmidt. “Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen,” 2007.","ieee":"H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, and S. Schmidt, “Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.” 2007.","van":"Brod H, Frahm B, Kauling J, Poggel M, Rose R, Schmidt S. Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. 2007.","short":"H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, S. Schmidt, (2007)."},"type":"patent","ipc":"B01J 19/28","ipn":"WO002007121958A1","year":2007,"abstract":[{"lang":"ger","text":"Gegenstand der Erfindung ist ein um seine ortsfeste, bevorzugt vertikale Achse oszillatorischrotierend angetriebener Reaktor für bevorzugt biotechnologische und pharmazeutische Anwendungen. Mit seinen prozessintensivierenden Eigenschaften für das Mischen, das Suspendieren, den Gasstofftransport, die Wärmeübertragung, die Bestrahlung und die Partikelrückhaltung wird die Anwendbarkeit im großtechnischen Maßstab gewährleistet. Der ohne Wellenabdichtung auskommende Reaktor erlaubt eine steriltechnisch besonders robuste Produktion unter Verzicht auf eine Reinigung und Reinigungsvalidierung erfordert, wenn der Reaktor als Einwegreaktor ausgeführt ist. "},{"text":"The subject matter of the invention is a reactor, driven about its fixed, preferably vertical, axis in an oscillatory/rotating manner, for preferably biotechnological and pharmaceutical applications. With its process-intensifying properties for mixing, suspending, gas transport, heat transfer, irradiation and particle retention, the applicability is ensured on a commercial scale. The reactor, which does not need a shaft seal, permits especially robust production with respect to sterile requirements while dispensing with cleaning and cleaning validation if the reactor is designed as a one-way reactor. ","lang":"eng"}],"_id":"2871","extern":"1","author":[{"last_name":"Brod","first_name":"Helmut","full_name":"Brod, Helmut"},{"last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn","id":"45666"},{"full_name":"Kauling, Jörg","first_name":"Jörg","last_name":"Kauling"},{"last_name":"Poggel","first_name":"Martin","full_name":"Poggel, Martin"},{"full_name":"Rose, Reinhold","first_name":"Reinhold","last_name":"Rose"},{"full_name":"Schmidt, Sebastian ","first_name":"Sebastian ","last_name":"Schmidt"}],"page":"56","status":"public"},{"year":2007,"conference":{"location":"Würzburg, Germany","start_date":"2007-03-05","end_date":"2007-03-06","name":"GVC Fachausschuss Mischvorgänge"},"type":"conference_speech","citation":{"apa":"Brod, H., Frahm, B., &#38; Kauling, J. (2007). <i>Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen</i>. 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Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007."},"type":"conference_speech","conference":{"start_date":"2007-05-14","location":"Osnabrück, Germany","name":"GVC / DECHEMA Vortrags- und Diskussionstagung „Aufarbeitung biotechnologischer Produkte\"","end_date":"2007-05-16"},"author":[{"full_name":"Brod, Helmut","first_name":"Helmut","last_name":"Brod"},{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"},{"first_name":"Jörg","full_name":"Kauling, Jörg","last_name":"Kauling"}],"language":[{"iso":"ger"}],"_id":"2910","extern":"1","status":"public"},{"extern":"1","language":[{"iso":"eng"}],"_id":"2967","author":[{"id":"45666","last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn"},{"first_name":"S.","full_name":"Kirchner, S.","last_name":"Kirchner"},{"last_name":"Rose","first_name":"R.","full_name":"Rose, R."},{"last_name":"Jenne","first_name":"M.","full_name":"Jenne, M."},{"last_name":"Kauling","full_name":"Kauling, J.","first_name":"J."},{"last_name":"Brod","first_name":"H.","full_name":"Brod, H."},{"last_name":"Jöris","first_name":"K.","full_name":"Jöris, K."},{"last_name":"Wischniewski","full_name":"Wischniewski, M.","first_name":"M."},{"full_name":"Langer, U.","first_name":"U.","last_name":"Langer"},{"first_name":"B.","full_name":"Bödeker, B.","last_name":"Bödeker"}],"status":"public","title":"High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)","user_id":"45666","date_updated":"2023-03-15T13:49:44Z","date_created":"2020-06-18T14:11:22Z","department":[{"_id":"DEP4021"}],"conference":{"start_date":"2007-12-07","location":"Leverkusen, Germany","name":"Technology Colloquium, BayKomm"},"type":"conference_poster","citation":{"havard":"B. Frahm, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, B. 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Langer und B. Bödeker. 2007. <i>High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)</i>.","ufg":"<b>Frahm, Björn et. al. (2007)</b>: High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA).","apa":"Frahm, B., Kirchner, S., Rose, R., Jenne, M., Kauling, J., Brod, H., … Bödeker, B. (2007). <i>High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)</i>. Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.","mla":"Frahm, Björn, et al. <i>High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA)</i>. 2007.","chicago":"Frahm, Björn, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, and B. 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Bödeker, High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2007."},"year":2007},{"status":"public","issue":"4","publication":"Chemie Ingenieur Technik","author":[{"first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm","id":"45666"},{"last_name":"Lane","first_name":"Paul","full_name":"Lane, Paul"},{"full_name":"Munack, Axel","first_name":"Axel","last_name":"Munack"},{"first_name":"Ralf","full_name":"Pörtner, Ralf","last_name":"Pörtner"}],"publisher":"WILEY-VCH Verlag","publication_status":"published","publication_identifier":{"eissn":["1522-2640"],"issn":["0009-286X"]},"volume":77,"intvolume":"        77","title":"Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode","page":"429-435","_id":"2347","language":[{"iso":"ger"}],"extern":"1","year":2005,"oa":"1","type":"scientific_journal_article","citation":{"ama":"Frahm B, Lane P, Munack A, Pörtner R. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. <i>Chemie Ingenieur Technik</i>. 2005;77(4):429-435. doi:<a href=\"https://doi.org/10.1002/cite.200407094\">10.1002/cite.200407094</a>","mla":"Frahm, Björn, et al. “Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode.” <i>Chemie Ingenieur Technik</i>, vol. 77, no. 4, WILEY-VCH Verlag, 2005, pp. 429–35, doi:<a href=\"https://doi.org/10.1002/cite.200407094\">10.1002/cite.200407094</a>.","chicago":"Frahm, Björn, Paul Lane, Axel Munack, and Ralf Pörtner. “Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode.” <i>Chemie Ingenieur Technik</i> 77, no. 4 (2005): 429–35. <a href=\"https://doi.org/10.1002/cite.200407094\">https://doi.org/10.1002/cite.200407094</a>.","ieee":"B. Frahm, P. Lane, A. Munack, and R. Pörtner, “Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode,” <i>Chemie Ingenieur Technik</i>, vol. 77, no. 4, pp. 429–435, 2005.","van":"Frahm B, Lane P, Munack A, Pörtner R. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. Chemie Ingenieur Technik. 2005;77(4):429–35.","short":"B. Frahm, P. Lane, A. Munack, R. Pörtner, Chemie Ingenieur Technik 77 (2005) 429–435.","havard":"B. Frahm, P. Lane, A. Munack, R. 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Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. <i>Bioprocess and Biosystems Engineering</i>. 2003;26(1):1-10. doi:<a href=\"https://doi.org/10.1007/s00449-003-0335-z\">10.1007/s00449-003-0335-z</a>"},"type":"scientific_journal_article","year":2003,"doi":"10.1007/s00449-003-0335-z","date_updated":"2023-03-15T13:49:39Z","main_file_link":[{"open_access":"1","url":"https://link.springer.com/article/10.1007/s00449-003-0335-z"}],"date_created":"2020-05-15T09:14:06Z","department":[{"_id":"DEP4021"}],"user_id":"45666","page":"1-10","_id":"2344","language":[{"iso":"eng"}],"extern":"1","quality_controlled":"1"},{"year":2003,"publication_identifier":{"isbn":[" \t978-3-8334-0111-4 "]},"citation":{"havard":"B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt : Books on Demand GmbH, 2003","ufg":"<b>Frahm, Björn (2003)</b>: Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Norderstedt.","chicago-de":"Frahm, Björn. 2003. <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH.","bjps":"<b>Frahm B</b> (2003) <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH.","apa":"Frahm, B. (2003). <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH.","mla":"Frahm, Björn. <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Books on Demand GmbH, 2003.","chicago":"Frahm, Björn. <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH, 2003.","ama":"Frahm B. <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH; 2003.","van":"Frahm B. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH; 2003. 120 p.","ieee":"B. Frahm, <i>Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen</i>. Norderstedt: Books on Demand GmbH, 2003.","short":"B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003."},"type":"dissertation","user_id":"45666","date_updated":"2023-03-15T13:49:39Z","date_created":"2020-05-19T14:44:50Z","department":[{"_id":"DEP4021"}],"title":"Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen","status":"public","keyword":["Tierzelle","Suspensionskultur","Prozesssteuerung"],"page":"120","author":[{"id":"45666","last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn"}],"place":"Norderstedt","publisher":"Books on Demand GmbH","publication_status":"published","language":[{"iso":"ger"}],"_id":"2393","abstract":[{"text":"Die wirtschaftlich immer mehr an Bedeutung gewinnende Kultivierung tierischer Zelllinien umfasst zahlreiche Anwendungen in der Pharmaherstellung und Medizintechnik. Eine Vielzahl der Produkte (Diagnostika, Impfstoffe, Therapeutika) wird in Fed-Batch-Prozessen hergestellt. Für die verbesserte Steuerung von derartigen Fed-Batch-Prozessen stellt der Autor eine adaptive, modellgestützte Steuerung vor. Anwendungsbeispiele veranschaulichen das Potential und die Flexibilität der Steuerung und ihre Universalität bezüglich verschiedener Kultivierungssysteme und Zelllinien. \r\n\r\nDa auch die gelöst-CO2-Konzentration und die Atmungsaktivität der Zellen zunehmend Bedeutung in der Prozessführung erlangen, stellt dieses Buch weiterhin die entwickelte Erfassung dieser Größen per Abgasanalytik und Modellierung des Kohlendioxidtransfers vor.","lang":"ger"}]},{"editor":[{"last_name":"Beckmann","full_name":"Beckmann, Dieter","first_name":"Dieter"}],"year":2003,"conference":{"end_date":"2002-10-02","name":"11. Heiligenstädter Kolloquium","location":"Heilbad Heiligenstadt","start_date":"2002-09-30"},"citation":{"chicago":"Frahm, Björn, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V. C. Hass, and R. Pörtner. <i>Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control</i>. Edited by Dieter Beckmann and Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld). <i>Technische Systeme Für Biotechnologie Und Umwelt</i>. Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik , 2003.","mla":"Frahm, Björn, et al. “Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control.” <i>Technische Systeme Für Biotechnologie Und Umwelt</i>, edited by Dieter Beckmann and Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld), Inst. für Bioprozess- und Analysenmesstechnik , 2003, pp. 503–09.","ieee":"B. Frahm <i>et al.</i>, <i>Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control</i>. Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik , 2003, pp. 503–509.","van":"Frahm B, Müller-Landré B, Wiggers de Almeida G, Singer M, Rausch M, Lane P, et al. 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C.</span> ; u. a.</span> ; <span style=\"font-variant:small-caps;\">Beckmann, D.</span> ; <span style=\"font-variant:small-caps;\">Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld)</span> (Hrsg.): <i>Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control</i>. Heiligenstadt : Inst. für Bioprozess- und Analysenmesstechnik , 2003","apa":"Frahm, B., Müller-Landré, B., Wiggers de Almeida, G., Singer, M., Rausch, M., Lane, P., … Pörtner, R. (2003). <i>Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control</i>. (D. Beckmann &#38; Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld), Eds.), <i>Technische Systeme für Biotechnologie und Umwelt</i> (pp. 503–509). Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik .","ama":"Frahm B, Müller-Landré B, Wiggers de Almeida G, et al. <i>Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control</i>. 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(2003)</b>: Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control, Heiligenstadt.","bjps":"<b>Frahm B <i>et al.</i></b> (2003) <i>Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control</i>, Beckmann D and Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld) (eds). Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik .","chicago-de":"Frahm, Björn, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V. C. Hass und R. Pörtner. 2003. <i>Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control</i>. Hg. von Dieter Beckmann und Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld). <i>Technische Systeme für Biotechnologie und Umwelt</i>. Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik ."},"type":"conference_editor_article","user_id":"45666","date_updated":"2023-03-15T13:49:40Z","department":[{"_id":"DEP4021"}],"date_created":"2020-05-20T13:59:48Z","page":"503-509","place":"Heiligenstadt","extern":"1","corporate_editor":["Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld)","Institut für Bioprozeß- und Analysenmeßtechnik "],"_id":"2435","language":[{"iso":"eng"}],"publication_identifier":{"isbn":["3-00-011287-1"]},"title":"Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control","status":"public","publication":"Technische Systeme für Biotechnologie und Umwelt","author":[{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"last_name":"Müller-Landré","full_name":"Müller-Landré, B.","first_name":"B."},{"last_name":"Wiggers de Almeida","full_name":"Wiggers de Almeida, G.","first_name":"G."},{"last_name":"Singer","first_name":"M.","full_name":"Singer, M."},{"first_name":"M.","full_name":"Rausch, M.","last_name":"Rausch"},{"last_name":"Lane","full_name":"Lane, P.","first_name":"P."},{"last_name":"Munack","first_name":"A.","full_name":"Munack, A."},{"last_name":"Hass","full_name":"Hass, V. 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Edited by European Federation of Chemical Engineering. <i> ECCE - 4th European Congress of Chemical Engineering</i>. Vol. 10. Granada: ECCE4, 2003.","mla":"Kühn, K., et al. “Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells.” <i> ECCE - 4th European Congress of Chemical Engineering</i>, edited by European Federation of Chemical Engineering, vol. 10, ECCE4, 2003.","apa":"Kühn, K., Frahm, B., Pörtner, R., Lane, P., Munack, A., &#38; Hass, V. C. (2003). <i>Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells</i>. (European Federation of Chemical Engineering, Ed.), <i> ECCE - 4th European Congress of Chemical Engineering</i> (Vol. 10). 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Presented at the “Zellkultur-Tag”, Sartorius-College, Göttingen, Germany.","bjps":"<b>Frahm B and Pörtner R</b> (2003) <i>Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung</i>. .","chicago-de":"Frahm, Björn und Ralf Pörtner. 2003. <i>Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung</i>.","ufg":"<b>Frahm, Björn/Pörtner, Ralf (2003)</b>: Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung."},"type":"conference_speech","conference":{"location":"Göttingen, Germany","start_date":"2003-02-13","name":"“Zellkultur-Tag”, Sartorius-College"},"year":2003,"title":"Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung","department":[{"_id":"DEP4021"}],"date_created":"2020-06-09T14:20:17Z","date_updated":"2023-03-15T13:49:43Z","user_id":"45666","status":"public","language":[{"iso":"ger"}],"_id":"2902","extern":"1","author":[{"last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn","id":"45666"},{"last_name":"Pörtner","full_name":"Pörtner, Ralf","first_name":"Ralf"}]},{"status":"public","extern":"1","_id":"2903","language":[{"iso":"ger"}],"author":[{"last_name":"Hass","full_name":"Hass, V. 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C.","first_name":"V. C.","last_name":"Hass"},{"last_name":"Munack","full_name":"Munack, A.","first_name":"A."}],"extern":"1","publication_status":"published","language":[{"iso":"eng"}],"_id":"2959","year":2000,"conference":{"name":"10. Heiligenstädter Kolloquium, Technische Systeme für Biotechnologie und Umwelt","end_date":"2000-10-11","start_date":"2000-10-09","location":"Heilbad Heiligenstadt, Germany"},"citation":{"din1505-2-1":"<span style=\"font-variant:small-caps;\">Hoffmann, M.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Schwabe, J.-O.</span> ; <span style=\"font-variant:small-caps;\">Lane, P.</span> ; <span style=\"font-variant:small-caps;\">Pörtner, R.</span> ; <span style=\"font-variant:small-caps;\">Hass, V. C.</span> ; <span style=\"font-variant:small-caps;\">Munack, A.</span>: <i>Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus</i>, 2000","havard":"M. Hoffmann, B. Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V.C. Hass, A. Munack, Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus, 2000.","apa":"Hoffmann, M., Frahm, B., Schwabe, J.-O., Lane, P., Pörtner, R., Hass, V. C., &#38; Munack, A. (2000). <i>Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus</i>. Presented at the 10. Heiligenstädter Kolloquium, Technische Systeme für Biotechnologie und Umwelt, Heilbad Heiligenstadt, Germany.","chicago-de":"Hoffmann, M., Björn Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V. C. Hass und A. 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