[{"status":"public","page":"5","publisher":"Technische Hochschule Ostwestfalen-Lippe","year":"2026","author":[{"id":"85848","full_name":"Süßle, Eberhard","first_name":"Eberhard","last_name":"Süßle"}],"ddc":["570"],"department":[{"_id":"DEP4021"}],"abstract":[{"text":"Plant-based meat alternatives continue to gain market relevance due to sustainability, ethical, and health considerations. However, replicating the texture, cohesion, and sensory attributes of animal-derived meat remains a major technological challenge. Microbial transglutaminase (mTGase), an enzyme that catalyzes covalent cross-linking between glutamine and lysine residues in proteins, has emerged as a promising structuring tool for improving protein network formation in plant-based systems. Produced via microbial fermentation, mTGase is calcium-independent and active across a broad range of food-processing conditions. This review summarizes the mechanism of action of mTGase, its reactivity toward major plant protein sources, and its functional role in comminuted, emulsified, and structured plant-based meat products. Particular emphasis is placed on the integration of mTGase with physical structuring technologies such as extrusion and shear-cell processing. Overall, mTGase represents a versatile enzymatic strategy for enhancing texture and cohesion while reducing reliance on synthetic binders in clean-label plant-based meat alternatives.","lang":"eng"}],"citation":{"chicago-de":"Süßle, Eberhard. 2026. Short Review on Microbial Transglutaminase (mTGase) as a Structuring Tool in Plant-Based Meat Alternatives: Mechanisms, Applications, Future Perspectives, Consumer Concerns and Market Adoption. Technische Hochschule Ostwestfalen-Lippe. doi:10.25644/7yns-b575, .","din1505-2-1":"Süßle, Eberhard: Short Review on Microbial Transglutaminase (mTGase) as a Structuring Tool in Plant-Based Meat Alternatives: Mechanisms, Applications, Future Perspectives, Consumer Concerns and Market Adoption, Technische Hochschule Ostwestfalen-Lippe (2026)","short":"E. Süßle, (2026).","chicago":"Süßle, Eberhard. “Short Review on Microbial Transglutaminase (MTGase) as a Structuring Tool in Plant-Based Meat Alternatives: Mechanisms, Applications, Future Perspectives, Consumer Concerns and Market Adoption.” Technische Hochschule Ostwestfalen-Lippe, 2026. https://doi.org/10.25644/7yns-b575.","apa":"Süßle, E. (2026). Short Review on Microbial Transglutaminase (mTGase) as a Structuring Tool in Plant-Based Meat Alternatives: Mechanisms, Applications, Future Perspectives, Consumer Concerns and Market Adoption. 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Süßle, Short Review on Microbial Transglutaminase (mTGase) as a Structuring Tool in Plant-Based Meat Alternatives: Mechanisms, Applications, Future Perspectives, Consumer Concerns and Market Adoption, (2026).","van":"Süßle E. Short Review on Microbial Transglutaminase (mTGase) as a Structuring Tool in Plant-Based Meat Alternatives: Mechanisms, Applications, Future Perspectives, Consumer Concerns and Market Adoption. Technische Hochschule Ostwestfalen-Lippe; 2026.","ieee":"E. Süßle, “Short Review on Microbial Transglutaminase (mTGase) as a Structuring Tool in Plant-Based Meat Alternatives: Mechanisms, Applications, Future Perspectives, Consumer Concerns and Market Adoption.” Technische Hochschule Ostwestfalen-Lippe, 2026. doi: 10.25644/7yns-b575.","ama":"Süßle E. Short Review on Microbial Transglutaminase (mTGase) as a Structuring Tool in Plant-Based Meat Alternatives: Mechanisms, Applications, Future Perspectives, Consumer Concerns and Market Adoption. Published online 2026. doi:10.25644/7yns-b575"},"publication_status":"published","file":[{"access_level":"open_access","success":1,"file_name":"Final_mTGtase.pdf","content_type":"application/pdf","date_created":"2026-03-27T09:30:11Z","file_id":"13630","file_size":152847,"creator":"adm-40d-sm4","relation":"main_file","date_updated":"2026-03-27T09:30:11Z"}],"title":"Short Review on Microbial Transglutaminase (mTGase) as a Structuring Tool in Plant-Based Meat Alternatives: Mechanisms, Applications, Future Perspectives, Consumer Concerns and Market Adoption","keyword":["microbial transglutaminase","plant-based meat","protein cross-linking","meat analogues","texture modification","regulatory classification","consumer perception","market adoption"],"language":[{"iso":"eng"}],"_id":"13629","doi":"10.25644/7yns-b575","oa":"1","has_accepted_license":"1","user_id":"83778","date_updated":"2026-03-27T10:45:52Z","file_date_updated":"2026-03-27T09:30:11Z","type":"preprint","date_created":"2026-03-27T09:31:16Z"},{"publication_status":"published","citation":{"short":"S. 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Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis.; 2025."},"title":"Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis","status":"public","conference":{"location":"Chemnitz","name":"18th International Workshop on Impedance Spectroscopy","start_date":"2025-09-23","end_date":"2025-09-26"},"department":[{"_id":"DEP4028"},{"_id":"DEP4021"}],"author":[{"first_name":"Selina","full_name":"Uhlendorff, Selina","id":"68713","last_name":"Uhlendorff","orcid":"https://orcid.org/0000-0002-0502-8032"},{"first_name":"Tatsiana","last_name":"Burankova","full_name":"Burankova, Tatsiana"},{"first_name":"Katharina","last_name":"Dahlmann","full_name":"Dahlmann, Katharina"},{"first_name":"Björn","last_name":"Frahm","id":"45666","full_name":"Frahm, Björn"},{"last_name":"Pein-Hackelbusch","first_name":"Miriam","id":"64952","full_name":"Pein-Hackelbusch, Miriam","orcid":"0000-0002-7920-0595"}],"year":"2025","related_material":{"link":[{"relation":"confirmation","url":"https://www.tu-chemnitz.de/etit/messtech/iwis/program.php"}]},"date_updated":"2026-03-27T16:51:16Z","user_id":"45666","type":"conference_poster","date_created":"2025-09-29T08:37:10Z","language":[{"iso":"eng"}],"_id":"13223"},{"conference":{"name":"5th annual Bioprocessing Summit Europe","location":"Barcelona, Spain","end_date":"2022-03-24","start_date":"2022-03-22"},"department":[{"_id":"DEP4021"}],"year":"2022","author":[{"last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja","id":"52466","first_name":"Tanja"},{"id":"68713","last_name":"Ramm","first_name":"Selina","full_name":"Ramm, Selina","orcid":"https://orcid.org/0000-0002-0502-8032"},{"last_name":"Lange-Hegermann","first_name":"Markus","full_name":"Lange-Hegermann, Markus","id":"71761"},{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"}],"status":"public","title":"A systematic, model-based workflow for risk-based decision making in upstream development","publication_status":"accepted","citation":{"din1505-2-1":"Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development","chicago-de":"Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann und Björn Frahm. A systematic, model-based workflow for risk-based decision making in upstream development.","short":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, n.d.","mla":"Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development.","havard":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, n.d.","bjps":"Hernández Rodriguez T et al. (n.d.) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. .","ufg":"Hernández Rodriguez, Tanja u. a.: A systematic, model-based workflow for risk-based decision making in upstream development, o. O. u. J. .","van":"Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. 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Frahm, A systematic, model-based workflow for risk-based decision making in upstream development."},"language":[{"iso":"eng"}],"_id":"7932","type":"conference_poster","date_created":"2022-05-04T19:35:20Z","date_updated":"2024-08-02T13:57:53Z","user_id":"83781"},{"date_created":"2022-05-05T11:14:10Z","type":"scientific_journal_article","publication_identifier":{"eissn":["2590-2628 "]},"publication":"Current Research in Biotechnology","date_updated":"2024-08-05T07:10:50Z","user_id":"83781","intvolume":" 4","language":[{"iso":"eng"}],"doi":"10.1016/j.crbiot.2022.01.005","_id":"7976","title":"Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology","publication_status":"published","volume":4,"citation":{"chicago-de":"Gassenmeier, Veronika, Sahar Deppe, Tanja Hernández Rodriguez, Fabian Kuhfuß, André Moser, Volker C. Hass, Kim B. Kuchemüller, u. a. 2022. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology 4: 102–119. doi:10.1016/j.crbiot.2022.01.005, .","din1505-2-1":"Gassenmeier, Veronika ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Kuhfuß, Fabian ; Moser, André ; Hass, Volker C. ; Kuchemüller, Kim B. ; Pörtner, Ralf ; u. a.: Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. In: Current Research in Biotechnology Bd. 4, Elsevier (2022), S. 102–119","short":"V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Current Research in Biotechnology 4 (2022) 102–119.","chicago":"Gassenmeier, Veronika, Sahar Deppe, Tanja Hernández Rodriguez, Fabian Kuhfuß, André Moser, Volker C. Hass, Kim B. 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Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology, Current Research in Biotechnology. 4 (2022) 102–119.","mla":"Gassenmeier, Veronika, et al. “Model-Assisted DoE Applied to Microalgae Processes, Current Research in Biotechnology.” Current Research in Biotechnology, vol. 4, 2022, pp. 102–19, https://doi.org/10.1016/j.crbiot.2022.01.005.","van":"Gassenmeier V, Deppe S, Hernández Rodriguez T, Kuhfuß F, Moser A, Hass VC, et al. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology. 2022;4:102–19.","ieee":"V. Gassenmeier et al., “Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology,” Current Research in Biotechnology, vol. 4, pp. 102–119, 2022, doi: 10.1016/j.crbiot.2022.01.005.","ama":"Gassenmeier V, Deppe S, Hernández Rodriguez T, et al. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology. 2022;4:102-119. doi:10.1016/j.crbiot.2022.01.005"},"department":[{"_id":"DEP4021"}],"year":"2022","author":[{"last_name":"Gassenmeier","first_name":"Veronika","full_name":"Gassenmeier, Veronika","id":"74048"},{"first_name":"Sahar","full_name":"Deppe, Sahar","last_name":"Deppe","id":"52121"},{"last_name":"Hernández Rodriguez","first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja","id":"52466"},{"first_name":"Fabian","full_name":"Kuhfuß, Fabian","last_name":"Kuhfuß"},{"last_name":"Moser","first_name":"André","full_name":"Moser, André"},{"full_name":"Hass, Volker C.","first_name":"Volker C.","last_name":"Hass"},{"last_name":"Kuchemüller","full_name":"Kuchemüller, Kim B.","first_name":"Kim B."},{"first_name":"Ralf","last_name":"Pörtner","full_name":"Pörtner, Ralf"},{"last_name":"Möller","first_name":"Johannes","full_name":"Möller, Johannes"},{"first_name":"George Adrian","id":"73814","full_name":"Ifrim, George Adrian","last_name":"Ifrim"},{"full_name":"Frahm, Björn","id":"45666","last_name":"Frahm","first_name":"Björn"}],"page":"102-119","status":"public","quality_controlled":"1","publisher":"Elsevier"},{"doi":"10.1007/s00449-021-02627-2","_id":"7977","place":"Berlin","intvolume":" 45","user_id":"83781","type":"scientific_journal_article","quality_controlled":"1","publisher":"Springer","abstract":[{"text":"Kinetic growth models are a useful tool for a better understanding of microalgal cultivation and for optimizing cultivation conditions. The evaluation of such models requires experimental data that is laborious to generate in bioreactor settings. The experimental shake flask setting used in this study allows to run 12 experiments at the same time, with 6 individual light intensities and light durations. This way, 54 biomass data sets were generated for the cultivation of the microalgae Chlorella vulgaris. To identify the model parameters, a stepwise parameter estimation procedure was applied. First, light-associated model parameters were estimated using additional measurements of local light intensities at differ heights within medium at different biomass concentrations. Next, substrate related model parameters were estimated, using experiments for which biomass and nitrate data were provided. Afterwards, growth-related model parameters were estimated by application of an extensive cross validation procedure.","lang":"eng"}],"department":[{"_id":"DEP4021"}],"publication_status":"published","language":[{"iso":"eng"}],"date_updated":"2024-08-05T07:07:37Z","date_created":"2022-05-05T11:28:56Z","publication":"Bioprocess and Biosystems Engineering","publication_identifier":{"eissn":["1615-7605"],"issn":["1615-7591 "]},"page":"15-30","status":"public","author":[{"last_name":"Kuhfuß","full_name":"Kuhfuß, Fabian","first_name":"Fabian"},{"last_name":"Gassenmeier","full_name":"Gassenmeier, Veronika","id":"74048","first_name":"Veronika"},{"last_name":"Deppe","full_name":"Deppe, Sahar","id":"52121","first_name":"Sahar"},{"first_name":"George Adrian","id":"73814","last_name":"Ifrim","full_name":"Ifrim, George Adrian"},{"full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja","last_name":"Hernández Rodriguez","id":"52466"},{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"}],"year":"2022","volume":45,"citation":{"chicago":"Kuhfuß, Fabian, Veronika Gassenmeier, Sahar Deppe, George Adrian Ifrim, Tanja Hernández Rodriguez, and Björn Frahm. “View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks.” Bioprocess and Biosystems Engineering 45 (2022): 15–30. https://doi.org/10.1007/s00449-021-02627-2.","apa":"Kuhfuß, F., Gassenmeier, V., Deppe, S., Ifrim, G. A., Hernández Rodriguez, T., & Frahm, B. (2022). View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering, 45, 15–30. https://doi.org/10.1007/s00449-021-02627-2","ufg":"Kuhfuß, Fabian u. a.: View on a mechanistic model of Chlorella vulgaris in incubated shake flasks, in: Bioprocess and Biosystems Engineering 45 (2022), S. 15–30.","mla":"Kuhfuß, Fabian, et al. “View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks.” Bioprocess and Biosystems Engineering, vol. 45, 2022, pp. 15–30, https://doi.org/10.1007/s00449-021-02627-2.","bjps":"Kuhfuß F et al. (2022) View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks. Bioprocess and Biosystems Engineering 45, 15–30.","havard":"F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. 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Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, Bioprocess and Biosystems Engineering 45 (2022) 15–30.","ieee":"F. Kuhfuß, V. Gassenmeier, S. Deppe, G. A. Ifrim, T. Hernández Rodriguez, and B. Frahm, “View on a mechanistic model of Chlorella vulgaris in incubated shake flasks,” Bioprocess and Biosystems Engineering, vol. 45, pp. 15–30, 2022, doi: 10.1007/s00449-021-02627-2.","ama":"Kuhfuß F, Gassenmeier V, Deppe S, Ifrim GA, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. 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Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction. 2021.","bjps":"Hernández Rodriguez T and Frahm B (2021) Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction. .","van":"Hernández Rodriguez T, Frahm B. Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. 2021.","ama":"Hernández Rodriguez T, Frahm B. Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction.; 2021."},"publication_status":"published","title":"Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction","status":"public","year":"2021","author":[{"first_name":"Tanja","last_name":"Hernández Rodriguez","id":"52466","full_name":"Hernández Rodriguez, Tanja"},{"full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn","id":"45666"}],"department":[{"_id":"DEP4021"}],"conference":{"name":"International Week 'Digitalization and Sustainability in Higher Education'","location":"SeAMK, Seinäjoki, Finnland","start_date":"2021-02-15","end_date":"2021-02-19"}},{"_id":"7931","language":[{"iso":"eng"}],"date_updated":"2023-03-15T13:50:12Z","user_id":"45673","date_created":"2022-05-04T19:32:05Z","type":"conference_poster","status":"public","conference":{"end_date":"2021-03-18","start_date":"2021-03-15","name":"24th International Congress of Chemical and Process Engineering, CHISA 2021","location":"as a web conference, Prague, Czech Republic"},"department":[{"_id":"DEP4021"}],"year":2021,"author":[{"first_name":"André","last_name":"Moser","full_name":"Moser, André"},{"full_name":"Möller, Johannes","first_name":"Johannes","last_name":"Möller"},{"full_name":"Kuchemüller, Kim B.","first_name":"Kim B.","last_name":"Kuchemüller"},{"first_name":"Sahar","last_name":"Deppe","full_name":"Deppe, Sahar"},{"full_name":"Hernández Rodriguez, Tanja","last_name":"Hernández Rodriguez","first_name":"Tanja","id":"52466"},{"first_name":"Veronika","id":"74048","last_name":"Gassenmeier","full_name":"Gassenmeier, Veronika"},{"full_name":"Ifrim, George Adrian","id":"73814","first_name":"George Adrian","last_name":"Ifrim"},{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"},{"last_name":"Pörtner","first_name":"Ralf","full_name":"Pörtner, Ralf"},{"last_name":"Hass","full_name":"Hass, Volker C.","first_name":"Volker C."}],"citation":{"short":"A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-Assisted Design of Experiments - Concept, Software and Applications, 2021.","chicago-de":"Moser, André, Johannes Möller, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Veronika Gassenmeier, George Adrian Ifrim, Björn Frahm, Ralf Pörtner und Volker C. Hass. 2021. Model-assisted Design of Experiments - Concept, Software and Applications.","din1505-2-1":"Moser, André ; Möller, Johannes ; Kuchemüller, Kim B. ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Ifrim, George Adrian ; Frahm, Björn ; u. a.: Model-assisted Design of Experiments - Concept, Software and Applications, 2021","van":"Moser A, Möller J, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Gassenmeier V, et al. Model-assisted Design of Experiments - Concept, Software and Applications. 2021.","ufg":"Moser, André et. al. (2021): Model-assisted Design of Experiments - Concept, Software and Applications.","mla":"Moser, André, et al. Model-Assisted Design of Experiments - Concept, Software and Applications. 2021.","bjps":"Moser A et al. (2021) Model-Assisted Design of Experiments - Concept, Software and Applications. .","havard":"A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-assisted Design of Experiments - Concept, Software and Applications, 2021.","apa":"Moser, A., Möller, J., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., … Hass, V. C. (2021). Model-assisted Design of Experiments - Concept, Software and Applications. Presented at the 24th International Congress of Chemical and Process Engineering, CHISA 2021, as a web conference, Prague, Czech Republic.","chicago":"Moser, André, Johannes Möller, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Veronika Gassenmeier, George Adrian Ifrim, Björn Frahm, Ralf Pörtner, and Volker C. Hass. Model-Assisted Design of Experiments - Concept, Software and Applications, 2021.","ama":"Moser A, Möller J, Kuchemüller KB, et al. Model-Assisted Design of Experiments - Concept, Software and Applications.; 2021.","ieee":"A. Moser et al., Model-assisted Design of Experiments - Concept, Software and Applications. 2021."},"title":"Model-assisted Design of Experiments - Concept, Software and Applications"},{"language":[{"iso":"eng"}],"_id":"7939","user_id":"45666","date_updated":"2023-03-15T13:50:12Z","publication":"MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science","type":"encyclopedia_article","date_created":"2022-05-04T20:09:13Z","status":"public","author":[{"last_name":"Wirtanen","first_name":"Gun","full_name":"Wirtanen, Gun"},{"last_name":"Alarinta","first_name":"Jarmo","full_name":"Alarinta, Jarmo"},{"first_name":"Björn","id":"45666","last_name":"Frahm","full_name":"Frahm, Björn"},{"last_name":"Fasse","first_name":"Sylvia","full_name":"Fasse, Sylvia"}],"year":2021,"department":[{"_id":"DEP4021"}],"citation":{"chicago":"Wirtanen, Gun, Jarmo Alarinta, Björn Frahm, and Sylvia Fasse. “Bovine Colostrum for Human Consumption.” In MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021.","ieee":"G. Wirtanen, J. Alarinta, B. Frahm, and S. Fasse, “Bovine Colostrum for Human Consumption,” in MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021.","apa":"Wirtanen, G., Alarinta, J., Frahm, B., & Fasse, S. (2021). Bovine Colostrum for Human Consumption. In MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science.","bjps":"Wirtanen G et al. (2021) Bovine Colostrum for Human Consumption. MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science.","havard":"G. Wirtanen, J. Alarinta, B. Frahm, S. Fasse, Bovine Colostrum for Human Consumption, in: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021.","mla":"Wirtanen, Gun, et al. “Bovine Colostrum for Human Consumption.” MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021.","ufg":"Wirtanen, Gun et. al. (2021): Bovine Colostrum for Human Consumption, in: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science.","ama":"Wirtanen G, Alarinta J, Frahm B, Fasse S. Bovine Colostrum for Human Consumption. In: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science. ; 2021.","van":"Wirtanen G, Alarinta J, Frahm B, Fasse S. Bovine Colostrum for Human Consumption. In: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science. 2021.","din1505-2-1":"Wirtanen, Gun ; Alarinta, Jarmo ; Frahm, Björn ; Fasse, Sylvia: Bovine Colostrum for Human Consumption. In: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021","chicago-de":"Wirtanen, Gun, Jarmo Alarinta, Björn Frahm und Sylvia Fasse. 2021. Bovine Colostrum for Human Consumption. In: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science.","short":"G. Wirtanen, J. Alarinta, B. Frahm, S. Fasse, in: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021."},"title":"Bovine Colostrum for Human Consumption"},{"type":"scientific_journal_article","intvolume":" 2","user_id":"83781","_id":"7981","doi":"10.3390/dairy2040044","place":"Basel","isi":"1","publication_status":"published","issue":"4","abstract":[{"lang":"eng","text":"The main purpose of bovine colostrum, being the milk secreted by a cow after giving birth, is to transfer passive immunity to the calf. The calves have an immature immune system as they lack immunoglobulins (Igs). Subsequently, the supply of good quality bovine colostrum is required. The quality of colostrum is classified by low bacterial counts and adequate Ig concentrations. Bacterial contamination can contain a variety of human pathogens or high counts of spoilage bacteria, which has become more challenging with the emerging use of bovine colostrum as food and food supplements. There is also a growing risk for the spread of zoonotic diseases originating from bovines. For this reason, processing based on heat treatment or other feasible techniques is required. This review provides an overview of literature on the microbial quality of bovine colostrum and processing methods to improve its microbial quality and keep its nutritional values as food. The highlights of this review are as follows: high quality colostrum is a valuable raw material in food products and supplements; the microbial safety of bovine colostrum is increased using an appropriate processing-suitable effective heat treatment which does not destroy the high nutrition value of colostrum; the heat treatment processes are cost-effective compared to other methods; and heat treatment can be performed in both small- and large-scale production."}],"department":[{"_id":"DEP4021"}],"publisher":"MDPI","quality_controlled":"1","publication_identifier":{"eissn":["2624-862X "]},"publication":"Dairy","date_created":"2022-05-05T12:51:45Z","date_updated":"2025-06-26T08:58:30Z","keyword":["bovine colostrum","bacteria","pathogens","probiotic bacteria","cost-effective processing","heat treatment","pasteurization","contamination control","immunoglobulins","enzymes"],"language":[{"iso":"eng"}],"title":"Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing","volume":2,"citation":{"short":"S. Fasse, J. Alarinta, B. Frahm, G. Wirtanen, Dairy 2 (2021) 556–575.","din1505-2-1":"Fasse, Sylvia ; Alarinta, Jarmo ; Frahm, Björn ; Wirtanen, Gun: Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. In: Dairy Bd. 2. Basel, MDPI (2021), Nr. 4, S. 556–575","chicago-de":"Fasse, Sylvia, Jarmo Alarinta, Björn Frahm und Gun Wirtanen. 2021. Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy 2, Nr. 4: 556–575. doi:10.3390/dairy2040044, .","apa":"Fasse, S., Alarinta, J., Frahm, B., & Wirtanen, G. (2021). Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy, 2(4), 556–575. https://doi.org/10.3390/dairy2040044","chicago":"Fasse, Sylvia, Jarmo Alarinta, Björn Frahm, and Gun Wirtanen. “Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing.” Dairy 2, no. 4 (2021): 556–75. https://doi.org/10.3390/dairy2040044.","van":"Fasse S, Alarinta J, Frahm B, Wirtanen G. Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy. 2021;2(4):556–75.","ufg":"Fasse, Sylvia u. a.: Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing, in: Dairy 2 (2021), H. 4, S. 556–575.","havard":"S. Fasse, J. Alarinta, B. Frahm, G. Wirtanen, Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing, Dairy. 2 (2021) 556–575.","bjps":"Fasse S et al. (2021) Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy 2, 556–575.","mla":"Fasse, Sylvia, et al. “Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing.” Dairy, vol. 2, no. 4, 2021, pp. 556–75, https://doi.org/10.3390/dairy2040044.","ieee":"S. Fasse, J. Alarinta, B. Frahm, and G. Wirtanen, “Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing,” Dairy, vol. 2, no. 4, pp. 556–575, 2021, doi: 10.3390/dairy2040044.","ama":"Fasse S, Alarinta J, Frahm B, Wirtanen G. Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy. 2021;2(4):556-575. doi:10.3390/dairy2040044"},"external_id":{"isi":["001178458700001"]},"year":"2021","author":[{"first_name":"Sylvia","last_name":"Fasse","full_name":"Fasse, Sylvia"},{"last_name":"Alarinta","full_name":"Alarinta, Jarmo","first_name":"Jarmo"},{"id":"45666","first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn"},{"first_name":"Gun","full_name":"Wirtanen, Gun","last_name":"Wirtanen"}],"status":"public","page":"556-575"},{"page":"49-74","status":"public","year":"2021","author":[{"first_name":"Tanja","id":"52466","full_name":"Hernández Rodriguez, Tanja","last_name":"Hernández Rodriguez"},{"last_name":"Morerod","full_name":"Morerod, Sophie","first_name":"Sophie"},{"first_name":"Ralf","last_name":"Pörtner","full_name":"Pörtner, Ralf"},{"first_name":"Florian M.","full_name":"Wurm, Florian M.","last_name":"Wurm"},{"id":"45666","last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn"}],"citation":{"chicago-de":"Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm und Björn Frahm. 2021. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, special issue:49–74. Processes : open access journal . Basel: MDPI. doi:10.3390/pr9060964, .","din1505-2-1":"Hernández Rodriguez, Tanja ; Morerod, Sophie ; Pörtner, Ralf ; Wurm, Florian M. ; Frahm, Björn: Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Processes : open access journal . Bd. special issue. Basel : MDPI, 2021, S. 49–74","short":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021, pp. 49–74.","havard":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021: pp. 49–74.","bjps":"Hernández Rodriguez T et al. (2021) Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue. Basel: MDPI, pp. 49–74.","mla":"Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study.” Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue, MDPI, 2021, pp. 49–74, https://doi.org/10.3390/pr9060964.","ufg":"Hernández Rodriguez, Tanja u. a.: Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: o. Hg.: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Band special issue, Basel 2021 (Processes : open access journal ), S. 49–74.","ama":"Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Vol special issue. Processes : open access journal . MDPI; 2021:49-74. doi:10.3390/pr9060964","van":"Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2021. p. 49–74. (Processes : open access journal ; vol. special issue).","chicago":"Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm, and Björn Frahm. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study.” In Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, special issue:49–74. Processes : Open Access Journal . Basel: MDPI, 2021. https://doi.org/10.3390/pr9060964.","ieee":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F. M. Wurm, and B. Frahm, “Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study,” in Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue, Basel: MDPI, 2021, pp. 49–74. doi: 10.3390/pr9060964.","apa":"Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm, B. (2021). Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue (pp. 49–74). MDPI. https://doi.org/10.3390/pr9060964"},"volume":"special issue","title":"Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study","language":[{"iso":"eng"}],"keyword":["clonal cell population","phenotypic diversity","inoculum train","uncertainty-based","cell culture model","biopharmaceutical manufacturing"],"date_updated":"2023-08-16T09:17:50Z","date_created":"2022-05-05T12:55:52Z","publication":"Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing","publication_identifier":{"issn":["2227-9717 "],"eisbn":["978-3-0365-5209-5"],"isbn":["978-3-0365-5210-1"]},"quality_controlled":"1","publisher":"MDPI","abstract":[{"text":"For the manufacturing of complex biopharmaceuticals using bioreactors with cultivated mammalian cells, high product concentration is an important objective. The phenotype of the cells in a reactor plays an important role. Are clonal cell populations showing high cell-specific growth rates more favorable than cell lines with higher cell-specific productivities or vice versa? Five clonal Chinese hamster ovary cell populations were analyzed based on the data of a 3-month-stability study. We adapted a mechanistic cell culture model to the experimental data of one such clonally derived cell population. Uncertainties and prior knowledge concerning model parameters were considered using Bayesian parameter estimations. This model was used then to define an inoculum train protocol. Based on this, we subsequently simulated the impacts of differences in growth rates (±10%) and production rates (±10% and ±50%) on the overall cultivation time, including making the inoculum train cultures; the final production phase, the volumetric titer in that bioreactor and the ratio of both, defined as overall process productivity. We showed thus unequivocally that growth rates have a higher impact (up to three times) on overall process productivity and for product output per year, whereas cells with higher productivity can potentially generate higher product concentrations in the production vessel.","lang":"eng"}],"department":[{"_id":"DEP4021"}],"publication_status":"published","series_title":"Processes : open access journal ","doi":"10.3390/pr9060964","_id":"7983","place":"Basel","user_id":"83781","type":"book_chapter"},{"title":"Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train","volume":44,"citation":{"ieee":"T. Hernández Rodriguez, C. Posch, R. Pörtner, and B. Frahm, “Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train,” Bioprocess and Biosystems Engineering, vol. 44, no. 4, pp. 793–808, 2021, doi: 10.1007/s00449-020-02488-1 .","ama":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering. 2021;44(4):793-808. doi:10.1007/s00449-020-02488-1 ","apa":"Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2021). Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering, 44(4), 793–808. https://doi.org/10.1007/s00449-020-02488-1 ","chicago":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, and Björn Frahm. “Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train.” Bioprocess and Biosystems Engineering 44, no. 4 (2021): 793–808. https://doi.org/10.1007/s00449-020-02488-1 .","van":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering. 2021;44(4):793–808.","ufg":"Hernández Rodriguez, Tanja u. a.: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, in: Bioprocess and Biosystems Engineering 44 (2021), H. 4, S. 793–808.","mla":"Hernández Rodriguez, Tanja, et al. “Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train.” Bioprocess and Biosystems Engineering, vol. 44, no. 4, 2021, pp. 793–808, https://doi.org/10.1007/s00449-020-02488-1 .","bjps":"Hernández Rodriguez T et al. (2021) Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train. Bioprocess and Biosystems Engineering 44, 793–808.","havard":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, Bioprocess and Biosystems Engineering. 44 (2021) 793–808.","short":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Bioprocess and Biosystems Engineering 44 (2021) 793–808.","din1505-2-1":"Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. In: Bioprocess and Biosystems Engineering Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 793–808","chicago-de":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner und Björn Frahm. 2021. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering 44, Nr. 4: 793–808. doi:10.1007/s00449-020-02488-1 , ."},"author":[{"last_name":"Hernández Rodriguez","id":"52466","full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja"},{"first_name":"Christoph","full_name":"Posch, Christoph","last_name":"Posch"},{"last_name":"Pörtner","first_name":"Ralf","full_name":"Pörtner, Ralf"},{"first_name":"Björn","last_name":"Frahm","id":"45666","full_name":"Frahm, Björn"}],"year":"2021","page":"793-808","status":"public","date_created":"2022-05-05T13:06:12Z","publication":"Bioprocess and Biosystems Engineering","publication_identifier":{"issn":["1615-7591"],"eissn":["1615-7605"]},"date_updated":"2023-08-21T07:51:38Z","language":[{"iso":"eng"}],"keyword":["Dynamic parameter estimation","Bioprocess","Cell cultures","Moving horizon estimation","Prior knowledge"],"publication_status":"published","department":[{"_id":"DEP4021"}],"issue":"4","abstract":[{"text":"Bioprocess modeling has become a useful tool for prediction of the process future with the aim to deduce operating decisions (e.g. transfer or feeds). Due to variabilities, which often occur between and within batches, updating (re-estimation) of model parameters is required at certain time intervals (dynamic parameter estimation) to obtain reliable predictions. This can be challenging in the presence of low sampling frequencies (e.g. every 24 h), different consecutive scales and large measurement errors, as in the case of cell culture seed trains. This contribution presents an iterative learning workflow which generates and incorporates knowledge concerning cell growth during the process by using a moving horizon estimation (MHE) approach for updating of model parameters. This estimation technique is compared to a classical weighted least squares estimation (WLSE) approach in the context of model updating over three consecutive cultivation scales (40–2160 L) of an industrial cell culture seed train. Both techniques were investigated regarding robustness concerning the aforementioned challenges and the required amount of experimental data (estimation horizon). It is shown how the proposed MHE can deal with the aforementioned difficulties by the integration of prior knowledge, even if only data at two sampling points are available, outperforming the classical WLSE approach. This workflow allows to adequately integrate current process behavior into the model and can therefore be a suitable component of a digital twin.","lang":"eng"}],"quality_controlled":"1","publisher":"Springer","type":"scientific_journal_article","user_id":"83781","intvolume":" 44","place":"Berlin ; Heidelberg [u.a.]","doi":"10.1007/s00449-020-02488-1 ","_id":"7985"},{"date_updated":"2023-08-21T07:55:05Z","publication":"Bioprocess and Biosystems Engineering","publication_identifier":{"isbn":["1615-7591"],"eissn":["1615-7605"]},"date_created":"2022-05-05T13:10:11Z","keyword":["Biocatalysis","Monte Carlo methods","Fed-batch strategy","Model-assisted design of experiments","Quality by design"],"language":[{"iso":"eng"}],"citation":{"chicago":"Moser, André, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Björn Frahm, Ralf Pörtner, Volker C. Hass, and Johannes Möller. “Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses.” Bioprocess and Biosystems Engineering 44, no. 4 (2021): 683–700. https://doi.org/10.1007/s00449-020-02478-3.","ieee":"A. Moser et al., “Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses,” Bioprocess and Biosystems Engineering, vol. 44, no. 4, pp. 683–700, 2021, doi: 10.1007/s00449-020-02478-3.","apa":"Moser, A., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Frahm, B., Pörtner, R., Hass, V. C., & Möller, J. (2021). Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering, 44(4), 683–700. https://doi.org/10.1007/s00449-020-02478-3","bjps":"Moser A et al. (2021) Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses. Bioprocess and Biosystems Engineering 44, 683–700.","mla":"Moser, André, et al. “Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses.” Bioprocess and Biosystems Engineering, vol. 44, no. 4, 2021, pp. 683–700, https://doi.org/10.1007/s00449-020-02478-3.","havard":"A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, Bioprocess and Biosystems Engineering. 44 (2021) 683–700.","ufg":"Moser, André u. a.: Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, in: Bioprocess and Biosystems Engineering 44 (2021), H. 4, S. 683–700.","ama":"Moser A, Kuchemüller KB, Deppe S, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering. 2021;44(4):683-700. doi:10.1007/s00449-020-02478-3","van":"Moser A, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Frahm B, Pörtner R, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering. 2021;44(4):683–700.","chicago-de":"Moser, André, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Björn Frahm, Ralf Pörtner, Volker C. Hass und Johannes Möller. 2021. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering 44, Nr. 4: 683–700. doi:10.1007/s00449-020-02478-3, .","din1505-2-1":"Moser, André ; Kuchemüller, Kim B. ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pörtner, Ralf ; Hass, Volker C. ; Möller, Johannes: Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. In: Bioprocess and Biosystems Engineering Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 683–700","short":"A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Bioprocess and Biosystems Engineering 44 (2021) 683–700."},"volume":44,"title":"Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses","status":"public","page":"683-700","year":"2021","author":[{"last_name":"Moser","first_name":"André","full_name":"Moser, André"},{"full_name":"Kuchemüller, Kim B.","first_name":"Kim B.","last_name":"Kuchemüller"},{"first_name":"Sahar","full_name":"Deppe, Sahar","last_name":"Deppe"},{"full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja","id":"52466","last_name":"Hernández Rodriguez"},{"last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn","id":"45666"},{"first_name":"Ralf","full_name":"Pörtner, Ralf","last_name":"Pörtner"},{"last_name":"Hass","full_name":"Hass, Volker C.","first_name":"Volker C."},{"last_name":"Möller","full_name":"Möller, Johannes","first_name":"Johannes"}],"user_id":"83781","intvolume":" 44","type":"scientific_journal_article","place":"Berlin ; Heidelberg [u.a.]","_id":"7986","doi":"10.1007/s00449-020-02478-3","publication_status":"published","publisher":"Springer","quality_controlled":"1","department":[{"_id":"DEP4021"}],"issue":"4","abstract":[{"lang":"eng","text":"Bioprocess development and optimization are still cost- and time-intensive due to the enormous number of experiments involved. In this study, the recently introduced model-assisted Design of Experiments (mDoE) concept (Möller et al. in Bioproc Biosyst Eng 42(5):867, https://doi.org/10.1007/s00449-019-02089-7, 2019) was extended and implemented into a software (“mDoE-toolbox”) to significantly reduce the number of required cultivations. The application of the toolbox is exemplary shown in two case studies with Saccharomyces cerevisiae. In the first case study, a fed-batch process was optimized with respect to the pH value and linearly rising feeding rates of glucose and nitrogen source. Using the mDoE-toolbox, the biomass concentration was increased by 30% compared to previously performed experiments. The second case study was the whole-cell biocatalysis of ethyl acetoacetate (EAA) to (S)-ethyl-3-hydroxybutyrate (E3HB), for which the feeding rates of glucose, nitrogen source, and EAA were optimized. An increase of 80% compared to a previously performed experiment with similar initial conditions was achieved for the E3HB concentration."}]},{"citation":{"ufg":"Blome, André u. a.: Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung, o. O. 2021.","havard":"A. Blome, M. Luttmann, B. Frahm, U. Müller, Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung, 2021.","mla":"Blome, André, et al. “Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung.” Seminar Life Science Technologies 2021-04-28, 2021.","bjps":"Blome A et al. (2021) Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung. .","van":"Blome A, Luttmann M, Frahm B, Müller U. Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. Seminar Life Science Technologies 2021-04-28. 2021.","ama":"Blome A, Luttmann M, Frahm B, Müller U. Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung.; 2021.","chicago":"Blome, André, Mario Luttmann, Björn Frahm, and Ulrich Müller. Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung. Seminar Life Science Technologies 2021-04-28, 2021.","apa":"Blome, A., Luttmann, M., Frahm, B., & Müller, U. (2021). Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. In Seminar Life Science Technologies 2021-04-28. Seminar Life Science Technologies, TH OWL, Lemgo, Germany.","ieee":"A. Blome, M. Luttmann, B. Frahm, and U. Müller, Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. 2021.","din1505-2-1":"Blome, André ; Luttmann, Mario ; Frahm, Björn ; Müller, Ulrich: Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung, 2021","chicago-de":"Blome, André, Mario Luttmann, Björn Frahm und Ulrich Müller. 2021. Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. Seminar Life Science Technologies 2021-04-28.","short":"A. Blome, M. Luttmann, B. Frahm, U. Müller, Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung, 2021."},"title":"Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung","status":"public","department":[{"_id":"DEP4021"},{"_id":"DEP1308"}],"conference":{"name":"Seminar Life Science Technologies, TH OWL","location":"Lemgo, Germany","end_date":"2021-04-28"},"author":[{"last_name":"Blome","first_name":"André","full_name":"Blome, André","id":"62117"},{"first_name":"Mario","last_name":"Luttmann","id":"63215","full_name":"Luttmann, Mario"},{"id":"45666","full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn"},{"last_name":"Müller","full_name":"Müller, Ulrich","id":"12119","first_name":"Ulrich"}],"year":"2021","date_updated":"2024-04-15T07:22:55Z","user_id":"81304","date_created":"2022-05-10T14:02:37Z","type":"conference_speech","publication":"Seminar Life Science Technologies 2021-04-28","language":[{"iso":"eng"}],"_id":"8078"},{"author":[{"last_name":"Hernández Rodriguez","first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja","id":"52466"},{"first_name":"Björn","id":"45666","full_name":"Frahm, Björn","last_name":"Frahm"}],"year":"2021","page":"97–131","status":"public","title":"Digital Seed Train Twins and Statistical Methods","volume":176,"citation":{"ama":"Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, eds. Digital Twins Tools and Concepts for Smart Biomanufacturing. Vol 176. Advances in Biochemical Engineering/Biotechnology. Springer; 2021:97-131. doi:https://doi.org/10.1007/10_2020_137","ieee":"T. Hernández Rodriguez and B. Frahm, “Digital Seed Train Twins and Statistical Methods,” in Digital Twins Tools and Concepts for Smart Biomanufacturing, vol. 176, C. Herwig, R. Pörtner, and J. Möller, Eds. Berlin, Heidelberg: Springer, 2021, pp. 97–131. doi: https://doi.org/10.1007/10_2020_137.","short":"T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021, pp. 97–131.","chicago-de":"Hernández Rodriguez, Tanja und Björn Frahm. 2021. Digital Seed Train Twins and Statistical Methods. In: Digital Twins Tools and Concepts for Smart Biomanufacturing, hg. von Christoph Herwig, Ralf Pörtner, und Johannes Möller, 176:97–131. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer. doi:https://doi.org/10.1007/10_2020_137, .","din1505-2-1":"Hernández Rodriguez, Tanja ; Frahm, Björn: Digital Seed Train Twins and Statistical Methods. In: Herwig, C. ; Pörtner, R. ; Möller, J. (Hrsg.): Digital Twins Tools and Concepts for Smart Biomanufacturing, Advances in Biochemical Engineering/Biotechnology. Bd. 176. Berlin, Heidelberg : Springer, 2021, S. 97–131","van":"Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, editors. Digital Twins Tools and Concepts for Smart Biomanufacturing. Berlin, Heidelberg: Springer; 2021. p. 97–131. (Advances in Biochemical Engineering/Biotechnology; vol. 176).","bjps":"Hernández Rodriguez T and Frahm B (2021) Digital Seed Train Twins and Statistical Methods. In Herwig C, Pörtner R and Möller J (eds), Digital Twins Tools and Concepts for Smart Biomanufacturing, vol. 176. Berlin, Heidelberg: Springer, pp. 97–131.","havard":"T. Hernández Rodriguez, B. Frahm, Digital Seed Train Twins and Statistical Methods, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021: pp. 97–131.","mla":"Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins and Statistical Methods.” Digital Twins Tools and Concepts for Smart Biomanufacturing, edited by Christoph Herwig et al., vol. 176, Springer, 2021, pp. 97–131, https://doi.org/10.1007/10_2020_137.","ufg":"Hernández Rodriguez, Tanja/Frahm, Björn: Digital Seed Train Twins and Statistical Methods, in: Herwig, Christoph/Pörtner, Ralf/Möller, Johannes (Hgg.): Digital Twins Tools and Concepts for Smart Biomanufacturing, Bd. 176, Berlin, Heidelberg 2021 (Advances in Biochemical Engineering/Biotechnology), S. 97–131.","apa":"Hernández Rodriguez, T., & Frahm, B. (2021). Digital Seed Train Twins and Statistical Methods. In C. Herwig, R. Pörtner, & J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing (Vol. 176, pp. 97–131). Springer. https://doi.org/10.1007/10_2020_137","chicago":"Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins and Statistical Methods.” In Digital Twins Tools and Concepts for Smart Biomanufacturing, edited by Christoph Herwig, Ralf Pörtner, and Johannes Möller, 176:97–131. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer, 2021. https://doi.org/10.1007/10_2020_137."},"language":[{"iso":"eng"}],"keyword":["Bayes","Digital twin","Parameter estimation","Seed train","Uncertainty"],"date_created":"2020-08-19T07:14:11Z","publication":"Digital Twins Tools and Concepts for Smart Biomanufacturing","publication_identifier":{"eissn":["1616-8542"],"isbn":["978-3-030-71659-2"],"eisbn":["978-3-030-71660-8"],"issn":["0724-6145"]},"date_updated":"2023-08-16T06:48:35Z","editor":[{"last_name":"Herwig","full_name":"Herwig, Christoph ","first_name":"Christoph "},{"last_name":"Pörtner","first_name":"Ralf ","full_name":"Pörtner, Ralf "},{"first_name":"Johannes ","last_name":"Möller","full_name":"Möller, Johannes "}],"department":[{"_id":"DEP4021"}],"abstract":[{"text":"Model-based concepts and simulation techniques in combination with digital tools emerge as a key to explore the full potential of biopharmaceutical production processes, which contain several challenging development and process steps. One of these steps is the time- and cost-intensive cell proliferation process (also called seed train) to increase cell number from cell thawing up to production scale. Challenges like complex cell metabolism, batch-to-batch variation, variabilities in cell behavior, and influences of changes in cultivation conditions necessitate adequate digital solutions to provide information about the current and near future process state to derive correct process decisions.\r\nFor this purpose digital seed train twins have proved to be efficient, which digitally display the time-dependent behavior of important process variables based on mathematical models, strategies, and adaption procedures.\r\nThis chapter will outline the needs for digitalization of seed trains, the construction of a digital seed train twin, the role of parameter estimation, and different statistical methods within this context, which are applicable to several problems in the field of bioprocessing. The results of a case study are presented to illustrate a Bayesian approach for parameter estimation and prediction of an industrial cell culture seed train for seed train digitalization.","lang":"eng"}],"quality_controlled":"1","publisher":"Springer","series_title":"Advances in Biochemical Engineering/Biotechnology","publication_status":"published","place":"Berlin, Heidelberg","doi":"https://doi.org/10.1007/10_2020_137","_id":"3349","type":"book_chapter","user_id":"83781","intvolume":" 176"},{"status":"public","conference":{"location":"als Web-Konferenz, Aachen, Germany","name":"10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020","start_date":"2020-09-21","end_date":"2020-09-24"},"department":[{"_id":"DEP4021"}],"year":2020,"author":[{"id":"52466","first_name":"Tanja","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja"},{"first_name":"Sahar","full_name":"Deppe, Sahar","last_name":"Deppe"},{"id":"74048","first_name":"Veronika","full_name":"Gassenmeier, Veronika","last_name":"Gassenmeier"},{"last_name":"Kuhfuß","full_name":"Kuhfuß, Fabian","first_name":"Fabian"},{"first_name":"Marius","last_name":"Tölle","full_name":"Tölle, Marius"},{"last_name":"Ifrim","id":"73814","first_name":"George Adrian","full_name":"Ifrim, George Adrian"},{"first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn","id":"45666"}],"citation":{"ieee":"T. Hernández Rodriguez et al., Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020.","ama":"Hernández Rodriguez T, Deppe S, Gassenmeier V, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration.; 2020.","apa":"Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.","chicago":"Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim, and Björn Frahm. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.","van":"Hernández Rodriguez T, Deppe S, Gassenmeier V, Kuhfuß F, Tölle M, Ifrim GA, et al. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020.","ufg":"Hernández Rodriguez, Tanja et. al. (2020): Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration.","havard":"T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020.","mla":"Hernández Rodriguez, Tanja, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. 2020.","bjps":"Hernández Rodriguez T et al. (2020) Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. .","short":"T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.","din1505-2-1":"Hernández Rodriguez, Tanja ; Deppe, Sahar ; Gassenmeier, Veronika ; Kuhfuß, Fabian ; Tölle, Marius ; Ifrim, George Adrian ; Frahm, Björn: Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020","chicago-de":"Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim und Björn Frahm. 2020. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration."},"title":"Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration","_id":"7929","language":[{"iso":"eng"}],"date_updated":"2023-03-15T13:50:12Z","user_id":"45673","date_created":"2022-05-04T19:22:33Z","type":"conference_poster"},{"citation":{"short":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020.","din1505-2-1":"Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020","chicago-de":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner und Björn Frahm. 2020. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes.","van":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. 2020.","havard":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020.","mla":"Hernández Rodriguez, Tanja, et al. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. 2020.","bjps":"Hernández Rodriguez T et al. (2020) Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. .","ufg":"Hernández Rodriguez, Tanja et. al. (2020): Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes.","apa":"Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.","chicago":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, and Björn Frahm. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020.","ama":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes.; 2020.","ieee":"T. Hernández Rodriguez, C. Posch, R. Pörtner, and B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. 2020."},"title":"Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes","status":"public","conference":{"start_date":"2020-09-21","end_date":"2020-09-24","name":"10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020","location":"als Web-Konferenz, Aachen, Germany"},"department":[{"_id":"DEP4021"}],"year":2020,"author":[{"last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja","id":"52466","first_name":"Tanja"},{"full_name":"Posch, Christoph","first_name":"Christoph","last_name":"Posch"},{"first_name":"Ralf","full_name":"Pörtner, Ralf","last_name":"Pörtner"},{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"}],"date_updated":"2023-03-15T13:50:12Z","user_id":"45666","type":"conference_poster","date_created":"2022-05-04T19:26:13Z","_id":"7930","language":[{"iso":"eng"}]},{"status":"public","department":[{"_id":"DEP4021"}],"conference":{"name":"1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable","location":"Sandoz, Austria","start_date":"2020-06-03"},"year":2020,"author":[{"last_name":"Hernández Rodriguez","id":"52466","first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja"},{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"first_name":"Christoph","last_name":"Posch","full_name":"Posch, Christoph"}],"citation":{"short":"T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support, 2020.","din1505-2-1":"Hernández Rodriguez, Tanja ; Frahm, Björn ; Posch, Christoph: Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020","chicago-de":"Hernández Rodriguez, Tanja, Björn Frahm und Christoph Posch. 2020. Integration of prior knowledge and digital tools for uncertainty-based decision support.","van":"Hernández Rodriguez T, Frahm B, Posch C. Integration of prior knowledge and digital tools for uncertainty-based decision support. 2020.","ama":"Hernández Rodriguez T, Frahm B, Posch C. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support.; 2020.","ufg":"Hernández Rodriguez, Tanja et. al. (2020): Integration of prior knowledge and digital tools for uncertainty-based decision support.","bjps":"Hernández Rodriguez T, Frahm B and Posch C (2020) Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support. .","havard":"T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020.","mla":"Hernández Rodriguez, Tanja, et al. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support. 2020.","apa":"Hernández Rodriguez, T., Frahm, B., & Posch, C. (2020). Integration of prior knowledge and digital tools for uncertainty-based decision support. Presented at the 1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable, Sandoz, Austria.","ieee":"T. Hernández Rodriguez, B. Frahm, and C. Posch, Integration of prior knowledge and digital tools for uncertainty-based decision support. 2020.","chicago":"Hernández Rodriguez, Tanja, Björn Frahm, and Christoph Posch. 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Frahm, Journal of Algal Biomass Utilization 5 (2014) 66–73."},"volume":5,"department":[{"_id":"DEP4021"}],"year":2014,"author":[{"last_name":"Hahne","full_name":"Hahne, T.","first_name":"T."},{"last_name":"Schwarze","first_name":"B.","full_name":"Schwarze, B."},{"full_name":"Kramer, M.","first_name":"M.","last_name":"Kramer"},{"last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn","id":"45666"}],"issue":"2","page":"66-73","status":"public","quality_controlled":"1","publisher":"PHYCO SPECTRUM"},{"date_created":"2020-06-05T14:36:16Z","type":"patent","user_id":"45666","date_updated":"2023-03-15T13:49:43Z","alternative_title":["Bioreactor designed as a photo-bioreactor comprises a disposable bag, which has a reactor chamber bounded by a wall, and light sources arranged in the immediate vicinity of the wall of the disposable bags "],"ipc":"C12M 1/42 ","ipn":"DE102012013587A1","_id":"2878","title":"Beleuchtung von disposable Bioreaktoren","citation":{"din1505-2-1":"Frahm, Björn ; Meier, Uwe: Beleuchtung von disposable Bioreaktoren (2014)","chicago-de":"Frahm, Björn und Uwe Meier. 2014. Beleuchtung von disposable Bioreaktoren.","short":"B. Frahm, U. Meier, (2014).","ufg":"Frahm, Björn/Meier, Uwe (2014): Beleuchtung von disposable Bioreaktoren.","havard":"B. Frahm, U. Meier, Beleuchtung von disposable Bioreaktoren, (2014).","bjps":"Frahm B and Meier U (2014) Beleuchtung von Disposable Bioreaktoren.","mla":"Frahm, Björn, and Uwe Meier. Beleuchtung von Disposable Bioreaktoren. 2014.","van":"Frahm B, Meier U. Beleuchtung von disposable Bioreaktoren. 2014.","ama":"Frahm B, Meier U. Beleuchtung von disposable Bioreaktoren. 2014.","chicago":"Frahm, Björn, and Uwe Meier. “Beleuchtung von Disposable Bioreaktoren,” 2014.","apa":"Frahm, B., & Meier, U. (2014). Beleuchtung von disposable Bioreaktoren.","ieee":"B. Frahm and U. Meier, “Beleuchtung von disposable Bioreaktoren.” 2014."},"application_number":"102012013587 ","abstract":[{"text":"Ein Bioreaktor mit einem Disposable Bag, der einen von einer Wandung (1) begrenzten Reaktorraum (2) aufweist, ist als Photo-Bioreaktor ausgelegt, bei dem in unmittelbarer Nachbarschaft der Wandung (1) des Disposable Bags Lichtquellen (LED-Streifen 6) angeordnet sind. ","lang":"ger"},{"text":"Bioreactor comprises a disposable bag, which has a reactor chamber (2) bounded by a wall (1), and light sources arranged in the immediate vicinity of the wall of the disposable bags. The bioreactor is designed as a photo-bioreactor. ","lang":"eng"}],"application_date":"2012-07-10","year":2014,"author":[{"full_name":"Frahm, Björn","first_name":"Björn","id":"45666","last_name":"Frahm"},{"full_name":"Meier, Uwe","first_name":"Uwe","last_name":"Meier"}],"department":[{"_id":"DEP4021"}],"publication_date":"2014-01-06","status":"public","page":"9"},{"_id":"2984","language":[{"iso":"ger"}],"date_created":"2020-06-22T13:33:18Z","type":"conference_poster","date_updated":"2023-03-15T13:49:44Z","user_id":"45666","department":[{"_id":"DEP4021"}],"conference":{"location":"Köthen, Germany","name":"7. Bundesalgenstammtisch","start_date":"2014-06-03","end_date":"2014-06-04"},"year":2014,"author":[{"full_name":"Drews, F.","first_name":"F.","last_name":"Drews"},{"first_name":"G.","last_name":"Drews","full_name":"Drews, G."},{"full_name":"Folz, C.","first_name":"C.","last_name":"Folz"},{"full_name":"Platz, G.","last_name":"Platz","first_name":"G."},{"full_name":"Gassenmeier, Thomas","id":"12675","last_name":"Gassenmeier","first_name":"Thomas"},{"full_name":"Kramer, M.","first_name":"M.","last_name":"Kramer"},{"first_name":"C.","last_name":"Hundeiker","full_name":"Hundeiker, C."},{"first_name":"B.","last_name":"Schwarze","full_name":"Schwarze, B."},{"last_name":"Frahm","first_name":"Björn","id":"45666","full_name":"Frahm, Björn"}],"status":"public","title":"Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche","publication_status":"published","citation":{"apa":"Drews, F., Drews, G., Folz, C., Platz, G., Gassenmeier, T., Kramer, M., … Frahm, B. (2014). Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. Presented at the 7. Bundesalgenstammtisch, Köthen, Germany.","chicago":"Drews, F., G. Drews, C. Folz, G. Platz, Thomas Gassenmeier, M. Kramer, C. Hundeiker, B. Schwarze, and Björn Frahm. Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche, 2014.","van":"Drews F, Drews G, Folz C, Platz G, Gassenmeier T, Kramer M, et al. Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. 2014.","bjps":"Drews F et al. (2014) Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. .","mla":"Drews, F., et al. Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. 2014.","havard":"F. Drews, G. Drews, C. Folz, G. Platz, T. Gassenmeier, M. 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Methods in Molecular Biology . Totowa, NJ: Humana Press. doi:10.1007/978-1-62703-733-4_22, .","din1505-2-1":"Frahm, Björn: Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology, Methods in Molecular Biology . Bd. 1104. Totowa, NJ : Humana Press, 2013, S. 355–367","short":"B. Frahm, in: Animal Cell Biotechnology, Humana Press, Totowa, NJ, 2013, pp. 355–367.","ufg":"Frahm, Björn (2013): Seed Train Optimization for Cell Culture, in: Animal Cell Biotechnology (=Methods in Molecular Biology 1104), Totowa, NJ, S. 355–367.","havard":"B. Frahm, Seed Train Optimization for Cell Culture, in: Animal Cell Biotechnology, Humana Press, Totowa, NJ, 2013: pp. 355–367.","mla":"Frahm, Björn. “Seed Train Optimization for Cell Culture.” Animal Cell Biotechnology, vol. 1104, Humana Press, 2013, pp. 355–67, doi:10.1007/978-1-62703-733-4_22.","bjps":"Frahm B (2013) Seed Train Optimization for Cell Culture. Animal Cell Biotechnology, vol. 1104. Totowa, NJ: Humana Press, pp. 355–367.","van":"Frahm B. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology. Totowa, NJ: Humana Press; 2013. p. 355–67. (Methods in Molecular Biology ; vol. 1104).","chicago":"Frahm, Björn. “Seed Train Optimization for Cell Culture.” In Animal Cell Biotechnology, 1104:355–67. Methods in Molecular Biology . Totowa, NJ: Humana Press, 2013. https://doi.org/10.1007/978-1-62703-733-4_22.","apa":"Frahm, B. (2013). Seed Train Optimization for Cell Culture. In Animal Cell Biotechnology (Vol. 1104, pp. 355–367). Totowa, NJ: Humana Press. https://doi.org/10.1007/978-1-62703-733-4_22","ama":"Frahm B. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology. Vol 1104. Methods in Molecular Biology . Totowa, NJ: Humana Press; 2013:355-367. doi:10.1007/978-1-62703-733-4_22","ieee":"B. Frahm, “Seed Train Optimization for Cell Culture,” in Animal Cell Biotechnology, vol. 1104, Totowa, NJ: Humana Press, 2013, pp. 355–367."},"title":"Seed Train Optimization for Cell Culture","page":"355-367","status":"public","author":[{"first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"}],"year":2013,"intvolume":" 1104","user_id":"74004","type":"book_chapter","doi":"10.1007/978-1-62703-733-4_22","_id":"2394","place":"Totowa, NJ","publication_status":"published","series_title":"Methods in Molecular Biology ","publisher":"Humana Press","abstract":[{"lang":"eng","text":"For the production of biopharmaceuticals a seed train is required to generate an adequate number of cells for inoculation of the production bioreactor. This seed train is time- and cost-intensive but offers potential for optimization. A method and a protocol are described for the seed train mapping, directed modeling without major effort, and its optimization regarding selected optimization criteria such as optimal points in time for cell passaging. Furthermore, the method can also be applied for the set-up of a new seed train, for example for a new cell line. Although the chapter is directed towards suspension cell lines, the method is also generally applicable, e.g. for adherent cell lines."}],"department":[{"_id":"DEP4021"}]},{"author":[{"id":"52466","first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja","last_name":"Hernández Rodriguez"},{"last_name":"Pörtner","first_name":"Ralf","full_name":"Pörtner, Ralf"},{"first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn","id":"45666"}],"main_file_link":[{"url":"https://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-7-S6-P9","open_access":"1"}],"year":2013,"department":[{"_id":"DEP4021"}],"publisher":"BioMed Central ","status":"public","title":"Seed train optimization for suspension cell culture","citation":{"chicago":"Hernández Rodriguez, Tanja, Ralf Pörtner, and Björn Frahm. Seed Train Optimization for Suspension Cell Culture. BMC Proceedings / BioMed Central . Vol. 7. 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Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, and R. Pörtner, Model-based design of the first steps of a seed train for cell culture processes, vol. 7. BioMed Central, 2013.","ama":"Kern S, Platas O, Schaletzky M, Sandig V, Frahm B, Pörtner R. Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes. Vol 7. BioMed Central; 2013. doi:10.1186/1753-6561-7-s6-p11","apa":"Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Model-based design of the first steps of a seed train for cell culture processes. BMC proceedings / BioMed Central (Vol. 7). BioMed Central. https://doi.org/10.1186/1753-6561-7-s6-p11","chicago":"Kern, Simon, Oscar Platas, Martin Schaletzky, Volker Sandig, Björn Frahm, and Ralf Pörtner. Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes. BMC Proceedings / BioMed Central . Vol. 7. 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Photobioreaktor mit rotatorisch oszillierenden Lichtquellen. 2012."},"application_number":" \t12166475","extern":"1","title":"Photobioreaktor mit rotatorisch oszillierenden Lichtquellen","publication_date":"2012-11-07","page":"19","status":"public","abstract":[{"lang":"ger","text":"Die Erfindung betrifft einen Photobioreaktor mit Belichtung durch rotatorisch oszillierend bewegte Lichtquellen (Lichtleiter, LEDs) sowie optional kombiniert rotatorisch oszillierend bewegte Membranflächen zum Gastransport. Vorteile sind unter anderem ein im zeitlichen Mittel räumlich homogener Lichteintrag, welcher über Intensität und Oszillation an die Kultur und deren Dichte angepasst werden kann, sowie ein scherarmer Leistungseintrag und optional eine scherarme blasenfreie Be- und Entgasung. "},{"text":"Photobioreactor comprises light sources, which are arbitrarily movable in rotational oscillation distributed in a bioreactor liquid volume. An independent claim is also included for using the photobioreactor, comprising executing an arbitrary discontinuous movement using the light sources. ","lang":"eng"}],"application_date":"2012-05-02","department":[{"_id":"DEP4021"}],"year":2012,"author":[{"last_name":"Brod","first_name":"Helmut","full_name":"Brod, Helmut"},{"first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm","id":"45666"}]},{"user_id":"45666","date_updated":"2023-03-15T13:49:43Z","publication":"Achema 2012","date_created":"2020-06-15T14:30:34Z","type":"conference_speech","language":[{"iso":"eng"}],"_id":"2918","citation":{"van":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Achema 2012. Vogel Business Media; 2012.","mla":"Van Hecke, W., et al. “Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor.” Achema 2012, Vogel Business Media, 2012.","havard":"W. 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Optimierung des Seed trains von Suspensions-Zellkulturen.","din1505-2-1":"Marzougui, R. ; Pörtner, R. ; Frahm, Björn: Optimierung des Seed trains von Suspensions-Zellkulturen, 2012"},"publication_status":"published","title":"Optimierung des Seed trains von Suspensions-Zellkulturen","status":"public","year":2012,"author":[{"first_name":"R.","full_name":"Marzougui, R.","last_name":"Marzougui"},{"last_name":"Pörtner","first_name":"R.","full_name":"Pörtner, R."},{"full_name":"Frahm, Björn","first_name":"Björn","id":"45666","last_name":"Frahm"}],"department":[{"_id":"DEP4021"}],"conference":{"start_date":"2012-05-14","end_date":"2012-05-16","name":"GVC / DECHEMA Vortrags- und Diskussionstagung “Biopharmazeutische Produktion”","location":"Freiburg, Germany"}},{"date_updated":"2023-03-15T13:49:39Z","publication":"Journal of Molecular Catalysis B: Enzymatic","publication_identifier":{"issn":["1381-1177"],"eisbn":["1873-3158"]},"date_created":"2020-05-15T10:21:22Z","language":[{"iso":"eng"}],"volume":68,"citation":{"ama":"Van Hecke W, Haltrich D, Frahm B, et al. A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic. 2011;68(2):154-161. doi:10.1016/j.molcatb.2010.10.004","ieee":"W. Van Hecke et al., “A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor,” Journal of Molecular Catalysis B: Enzymatic, vol. 68, no. 2, pp. 154–161, 2011.","short":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, J. Dewulf, H. Van Langenhove, R. Ludwig, Journal of Molecular Catalysis B: Enzymatic 68 (2011) 154–161.","din1505-2-1":"Van Hecke, Wouter ; Haltrich, Dietmar ; Frahm, Björn ; Brod, Helmut ; Dewulf, Jo ; Van Langenhove, Herman ; Ludwig, Roland: A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. In: Journal of Molecular Catalysis B: Enzymatic Bd. 68, Elsevier (2011), Nr. 2, S. 154–161","chicago-de":"Van Hecke, Wouter, Dietmar Haltrich, Björn Frahm, Helmut Brod, Jo Dewulf, Herman Van Langenhove und Roland Ludwig. 2011. A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic 68, Nr. 2: 154–161. doi:10.1016/j.molcatb.2010.10.004, .","van":"Van Hecke W, Haltrich D, Frahm B, Brod H, Dewulf J, Van Langenhove H, et al. A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic. 2011;68(2):154–61.","ufg":"Van Hecke, Wouter et. al. (2011): A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor, in: Journal of Molecular Catalysis B: Enzymatic 68 (2), S. 154–161.","bjps":"Van Hecke W et al. (2011) A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor. Journal of Molecular Catalysis B: Enzymatic 68, 154–161.","mla":"Van Hecke, Wouter, et al. “A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor.” Journal of Molecular Catalysis B: Enzymatic, vol. 68, no. 2, Elsevier, 2011, pp. 154–61, doi:10.1016/j.molcatb.2010.10.004.","havard":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, J. Dewulf, H. Van Langenhove, R. Ludwig, A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor, Journal of Molecular Catalysis B: Enzymatic. 68 (2011) 154–161.","apa":"Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., Dewulf, J., Van Langenhove, H., & Ludwig, R. (2011). A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic, 68(2), 154–161. https://doi.org/10.1016/j.molcatb.2010.10.004","chicago":"Van Hecke, Wouter, Dietmar Haltrich, Björn Frahm, Helmut Brod, Jo Dewulf, Herman Van Langenhove, and Roland Ludwig. “A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor.” Journal of Molecular Catalysis B: Enzymatic 68, no. 2 (2011): 154–61. https://doi.org/10.1016/j.molcatb.2010.10.004."},"title":"A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor","extern":"1","status":"public","page":"154-161","author":[{"first_name":"Wouter","full_name":"Van Hecke, Wouter","last_name":"Van Hecke"},{"last_name":"Haltrich","first_name":"Dietmar","full_name":"Haltrich, Dietmar"},{"last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn","id":"45666"},{"first_name":"Helmut","full_name":"Brod, Helmut","last_name":"Brod"},{"full_name":"Dewulf, Jo","first_name":"Jo","last_name":"Dewulf"},{"full_name":"Van Langenhove, Herman","last_name":"Van Langenhove","first_name":"Herman"},{"full_name":"Ludwig, Roland","last_name":"Ludwig","first_name":"Roland"}],"main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S1381117710002663"}],"year":2011,"intvolume":" 68","user_id":"45666","type":"scientific_journal_article","_id":"2350","doi":"10.1016/j.molcatb.2010.10.004","publication_status":"published","publisher":"Elsevier","quality_controlled":"1","issue":"2","department":[{"_id":"DEP4021"}]},{"_id":"2876","ipn":"O002011032652A1 ","ipc":"C12M 1/08 ","alternative_title":["Liquid Aerator"],"user_id":"45666","date_updated":"2023-03-15T13:49:43Z","type":"patent","date_created":"2020-06-05T14:28:44Z","status":"public","page":"32","publication_date":"2011-03-24","year":2011,"author":[{"full_name":"Brod, Helmut","first_name":"Helmut","last_name":"Brod"},{"id":"45666","last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn"},{"first_name":"Marc","full_name":"Jenne, Marc","last_name":"Jenne"},{"last_name":"Kauling","first_name":"Jörg","full_name":"Kauling, Jörg"},{"last_name":"Schmitt","first_name":"Franz","full_name":"Schmitt, Franz"},{"first_name":"Juri","full_name":"Seletzky, Juri","last_name":"Seletzky"}],"department":[{"_id":"DEP4021"}],"abstract":[{"lang":"ger","text":"Die Erfindung betrifft einen Begaser zum Eintrag eines Gases oder Gasgemisches in eine Flüssigkeit sowie ein Verfahren zur Begasung von Flüssigkeiten. Der erf?ndungsgemäße Begaser umfasst einen Hohlraum, einen Gaseinlass zum Einleiten eines Gases in den Hohlraum und zwei oder mehr Flächen, die formschlüssig aufeinander gepresst sind oder gepresst werden können, so dass ein durch den Gaseinlass in den Hohlraum gedrücktes Gas durch die zwischen den zusammengepressten Flächen auftretenden Spalten entweicht. "},{"lang":"eng","text":" The invention relates to an aerator for introducing a gas or gas mixture into a liquid and to a method for aerating liquids. The aerator according to the invention comprises a cavity, a gas inlet for directing a gas into the cavity and two or more surfaces that are or can be pressed against one another in a form-fit such that a gas that is forced into the cavity by means of the gas inlet escapes through gaps that form between the compressed surfaces. "}],"application_date":"2010-09-04","application_number":"2010005442 ","citation":{"short":"H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, J. Seletzky, (2011).","din1505-2-1":"Brod, Helmut ; Frahm, Björn ; Jenne, Marc ; Kauling, Jörg ; Schmitt, Franz ; Seletzky, Juri: Flüssigkeitsbegaser (2011)","chicago-de":"Brod, Helmut, Björn Frahm, Marc Jenne, Jörg Kauling, Franz Schmitt und Juri Seletzky. 2011. Flüssigkeitsbegaser.","apa":"Brod, H., Frahm, B., Jenne, M., Kauling, J., Schmitt, F., & Seletzky, J. (2011). Flüssigkeitsbegaser.","chicago":"Brod, Helmut, Björn Frahm, Marc Jenne, Jörg Kauling, Franz Schmitt, and Juri Seletzky. “Flüssigkeitsbegaser,” 2011.","van":"Brod H, Frahm B, Jenne M, Kauling J, Schmitt F, Seletzky J. Flüssigkeitsbegaser. 2011.","ufg":"Brod, Helmut et. al. (2011): Flüssigkeitsbegaser.","bjps":"Brod H et al. (2011) Flüssigkeitsbegaser.","havard":"H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, J. Seletzky, Flüssigkeitsbegaser, (2011).","mla":"Brod, Helmut, et al. Flüssigkeitsbegaser. 2011.","ieee":"H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, and J. Seletzky, “Flüssigkeitsbegaser.” 2011.","ama":"Brod H, Frahm B, Jenne M, Kauling J, Schmitt F, Seletzky J. Flüssigkeitsbegaser. 2011."},"title":"Flüssigkeitsbegaser","extern":"1"},{"publication_status":"published","citation":{"ieee":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, and R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. 2011.","ama":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor.; 2011.","short":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, 2011.","din1505-2-1":"Van Hecke, W. ; Haltrich, D. ; Frahm, Björn ; Brod, H. ; Ludwig, R.: Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor, 2011","chicago-de":"Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod und R. Ludwig. 2011. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor.","apa":"Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., & Ludwig, R. (2011). Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Presented at the 1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting, Berlin, Germany.","chicago":"Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod, and R. Ludwig. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, 2011.","van":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. 2011.","bjps":"Van Hecke W et al. (2011) Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. .","havard":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor, 2011.","mla":"Van Hecke, W., et al. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. 2011.","ufg":"Van Hecke, W. et. al. (2011): Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor."},"extern":"1","title":"Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor","status":"public","department":[{"_id":"DEP4021"}],"conference":{"start_date":"2011-09-25","end_date":"2011-09-29","location":"Berlin, Germany","name":"1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting"},"year":2011,"author":[{"first_name":"W.","last_name":"Van Hecke","full_name":"Van Hecke, W."},{"first_name":"D.","full_name":"Haltrich, D.","last_name":"Haltrich"},{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"},{"last_name":"Brod","full_name":"Brod, H.","first_name":"H."},{"full_name":"Ludwig, R.","last_name":"Ludwig","first_name":"R."}],"date_updated":"2023-03-15T13:49:44Z","user_id":"45666","type":"conference_poster","date_created":"2020-06-18T14:28:39Z","language":[{"iso":"eng"}],"_id":"2972"},{"_id":"2815","language":[{"iso":"eng"}],"date_updated":"2023-03-15T13:49:43Z","user_id":"45666","date_created":"2020-06-04T13:18:51Z","type":"conference_editor_article","publication":"Proceedings 19th International Congress of Chemical and Process Engineering","publication_identifier":{"isbn":["978-80-02-02250-3","978-80-02-02210-7 (CD-ROM)"]},"publisher":"Czech Society of Chemical Engineering","status":"public","conference":{"start_date":"2010-08-28","end_date":"2010-09-01","location":"Prague, CZ","name":"7th European Congress of Chemical Engineering ; 19th International Congress of Chemical and Process Engineering"},"department":[{"_id":"DEP4021"}],"year":2010,"author":[{"last_name":"Dercks","first_name":"B.","full_name":"Dercks, B."},{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"},{"first_name":"M.","last_name":"Grünewald","full_name":"Grünewald, M."},{"first_name":"E.","last_name":"Kenig","full_name":"Kenig, E."},{"full_name":"Lautenschleger, A.","last_name":"Lautenschleger","first_name":"A."},{"full_name":"Gorak, A.","first_name":"A.","last_name":"Gorak"},{"first_name":"P. ","last_name":"Schmidt","full_name":"Schmidt, P. "},{"first_name":"D.","last_name":"Sudhoff","full_name":"Sudhoff, D."},{"first_name":"S.","last_name":"Ressler","full_name":"Ressler, S."},{"full_name":"Zecirovic, R.","first_name":"R.","last_name":"Zecirovic"}],"publication_status":"published","citation":{"chicago":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, and R. Zecirovic. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering, 2010.","apa":"Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Prague, CZ: Czech Society of Chemical Engineering.","ieee":"B. Dercks et al., Intensified absorption and distillation devices for modular chemical production processes. Czech Society of Chemical Engineering, 2010.","ufg":"Dercks, B. et. al. (2010): Intensified absorption and distillation devices for modular chemical production processes.","mla":"Dercks, B., et al. “Intensified Absorption and Distillation Devices for Modular Chemical Production Processes.” Proceedings 19th International Congress of Chemical and Process Engineering, Czech Society of Chemical Engineering, 2010.","bjps":"Dercks B et al. (2010) Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. Czech Society of Chemical Engineering.","havard":"B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified absorption and distillation devices for modular chemical production processes, Czech Society of Chemical Engineering, 2010.","van":"Dercks B, Frahm B, Grünewald M, Kenig E, Lautenschleger A, Gorak A, et al. Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering; 2010.","ama":"Dercks B, Frahm B, Grünewald M, et al. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. Czech Society of Chemical Engineering; 2010.","din1505-2-1":"Dercks, B. ; Frahm, Björn ; Grünewald, M. ; Kenig, E. ; Lautenschleger, A. ; Gorak, A. ; Schmidt, P. ; Sudhoff, D. ; u. a.: Intensified absorption and distillation devices for modular chemical production processes : Czech Society of Chemical Engineering, 2010","chicago-de":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler und R. Zecirovic. 2010. Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering.","short":"B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, Czech Society of Chemical Engineering, 2010."},"extern":"1","title":"Intensified absorption and distillation devices for modular chemical production processes"},{"application_number":"2009006722 ","citation":{"ieee":"H. Brod, B. Frahm, and J. Kauling, “Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.” 2010.","ama":"Brod H, Frahm B, Kauling J. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen. 2010.","chicago":"Brod, Helmut, Björn Frahm, and Jörg Kauling. “Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen,” 2010.","apa":"Brod, H., Frahm, B., & Kauling, J. (2010). Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","mla":"Brod, Helmut, et al. Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen. 2010.","bjps":"Brod H, Frahm B and Kauling J (2010) Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen.","havard":"H. Brod, B. Frahm, J. Kauling, Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen, (2010).","ufg":"Brod, Helmut et. al. (2010): Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","van":"Brod H, Frahm B, Kauling J. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen. 2010.","chicago-de":"Brod, Helmut, Björn Frahm und Jörg Kauling. 2010. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","din1505-2-1":"Brod, Helmut ; Frahm, Björn ; Kauling, Jörg: Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen (2010)","short":"H. Brod, B. Frahm, J. Kauling, (2010)."},"extern":"1","title":"Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen","page":"26","status":"public","publication_date":"2010-04-01","department":[{"_id":"DEP4021"}],"author":[{"first_name":"Helmut","full_name":"Brod, Helmut","last_name":"Brod"},{"full_name":"Frahm, Björn","first_name":"Björn","id":"45666","last_name":"Frahm"},{"full_name":"Kauling, Jörg","last_name":"Kauling","first_name":"Jörg"}],"year":2010,"application_date":"2009-09-17","abstract":[{"text":"Die Erfindung betrifft ein Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen, insbesondere von Zellkulturen, welche zur Agglomeration bzw. Anhaftung an den Bioreaktor und seine Elemente neigen, oder bei denen Zelldebris oder Substanzen leicht agglomerieren bzw. anhaften.","lang":"ger"},{"lang":"eng","text":"The invention relates to a method for reducing deposits during the cultivation of organisms, particularly cell cultures, which tend to agglomerate or adhere to the bioreactor and the elements thereof, or in which cell debris or substances easily agglomerate or adhere. "}],"date_updated":"2023-03-15T13:49:43Z","user_id":"45666","date_created":"2020-06-05T14:12:21Z","type":"patent","_id":"2873","ipn":"WO002010034428A2","alternative_title":["Method for reducing deposits during the cultivation of organisms"],"ipc":"C12N 5/00"},{"title":"Bioreaktor","extern":"1","citation":{"ufg":"Brod, Helmut et. al. (2010): Bioreaktor.","havard":"H. Brod, B. Frahm, M. Jenne, J. Kauling, Bioreaktor, (2010).","bjps":"Brod H et al. (2010) Bioreaktor.","mla":"Brod, Helmut, et al. Bioreaktor. 2010.","van":"Brod H, Frahm B, Jenne M, Kauling J. Bioreaktor. 2010.","ama":"Brod H, Frahm B, Jenne M, Kauling J. Bioreaktor. 2010.","chicago":"Brod, Helmut, Björn Frahm, Marc Jenne, and Jörg Kauling. “Bioreaktor,” 2010.","apa":"Brod, H., Frahm, B., Jenne, M., & Kauling, J. (2010). Bioreaktor.","ieee":"H. Brod, B. Frahm, M. Jenne, and J. Kauling, “Bioreaktor.” 2010.","chicago-de":"Brod, Helmut, Björn Frahm, Marc Jenne und Jörg Kauling. 2010. Bioreaktor.","din1505-2-1":"Brod, Helmut ; Frahm, Björn ; Jenne, Marc ; Kauling, Jörg: Bioreaktor (2010)","short":"H. Brod, B. Frahm, M. Jenne, J. Kauling, (2010)."},"application_number":"2009008733 ","application_date":"2009-12-08","abstract":[{"text":"Die Erfindung betrifft einen Bioreaktor, die Verwendung des Bioreaktors zur Kultivierung von Mikroorganismen oder Zellkulturen sowie ein Verfahren zur Kultivierung von Mikroorganismen oder Zellkulturen. ","lang":"ger"},{"text":"The invention relates to a bioreactor, to the use of the bioreactor for culturing microorganisms or cell cultures, and also to a method for culturing microorganisms or cell cultures. ","lang":"eng"}],"author":[{"last_name":"Brod","first_name":"Helmut","full_name":"Brod, Helmut"},{"first_name":"Björn","last_name":"Frahm","id":"45666","full_name":"Frahm, Björn"},{"first_name":"Marc","last_name":"Jenne","full_name":"Jenne, Marc"},{"full_name":"Kauling, Jörg","first_name":"Jörg","last_name":"Kauling"}],"year":2010,"department":[{"_id":"DEP4021"}],"publication_date":"2010-06-24","status":"public","page":"27","date_created":"2020-06-05T14:17:50Z","type":"patent","user_id":"45666","date_updated":"2023-03-15T13:49:43Z","alternative_title":["Mikrogespargter Air-Lift-Bioreaktor für die Zellkultur"],"ipc":"C12M 1/04","ipn":"WO002010069492A1","_id":"2874"},{"application_date":"2010-01-13","abstract":[{"text":"Gegenstand der Erfindung ist ein neuartiges Begasungssystem, das insbesondere aber nicht ausschließlich in der Biotechnologie zur Versorgung von Zellen oder Mikroorganismen mit Sauerstoff einsetzbar ist. Das Begasungssystem umfasst eine Blasensäule und einen Verteiler. In dem Gefäß befindet sich ferner ein flüssiges Medium, das mit Gas versorgt werden soll. Es wird ein Vektor als Transportmittel für das Gas eingesetzt. Das Gas wird in die Blasensäule eingetragen und hier von dem Vektor aufgenommen. Der Vektor wird in Tropfenform über den Verteiler auf die Flüssigkeitsoberfläche aufgetragen, sinkt in dem Medium nach unten und gibt einen Teil des aufgenommenen Gases an das Medium ab. Am Boden des Gefäßes befindet sich eine Sammelvorrichtung, in der die Vektortropfen koaleszieren und wieder in die Blasensäule gelangen. Gegenstand der Erfindung ist weiterhin ein Bioreaktor umfassend das neuartige Begasungssystem. Gegenstand der Erfindung ist ferner ein Verfahren zur Begasung eines flüssigen Mediums, vorzugsweise einer Zellen oder Mikroorganismen enthaltenden wässrigen Suspension. ","lang":"ger"},{"text":" The invention relates to a novel gassing system that can be used particularly but not exclusively in biotechnology for supplying oxygen to cells or microorganisms. The gassing system comprises a bubble column and a distributor. There is furthermore a fluid medium in the tank that is to be supplied with gas. A vector is used as a transport means for the gas. The gas is incorporated into the bubble column and taken up by the vector here. The vector is applied to the fluid surface in droplet form via the distributor, sinks down into the medium and releases a portion of the absorbed gas to the medium. There is a collection device on the floor of the tank wherein the vector drops coalesce and enter the bubble column again. The invention furthermore relates to a bioreactor comprising the novel gassing system. The invention furthermore relates to a method for gassing a fluid medium, preferably an aqueous suspension comprising cells or microorganisms. ","lang":"eng"}],"department":[{"_id":"DEP4021"}],"year":2010,"author":[{"last_name":"Frahm","id":"45666","full_name":"Frahm, Björn","first_name":"Björn"},{"first_name":"Jörg","last_name":"Kauling","full_name":"Kauling, Jörg"},{"full_name":"Pütz, Andre","last_name":"Pütz","first_name":"Andre"},{"full_name":"Schindler, Markus","last_name":"Schindler","first_name":"Markus"}],"publication_date":"2010-07-09","page":"35","status":"public","extern":"1","title":"Begasungssystem","citation":{"short":"B. Frahm, J. Kauling, A. Pütz, M. Schindler, (2010).","chicago-de":"Frahm, Björn, Jörg Kauling, Andre Pütz und Markus Schindler. 2010. Begasungssystem.","din1505-2-1":"Frahm, Björn ; Kauling, Jörg ; Pütz, Andre ; Schindler, Markus: Begasungssystem (2010)","van":"Frahm B, Kauling J, Pütz A, Schindler M. Begasungssystem. 2010.","ama":"Frahm B, Kauling J, Pütz A, Schindler M. Begasungssystem. 2010.","ufg":"Frahm, Björn et. al. (2010): Begasungssystem.","havard":"B. Frahm, J. Kauling, A. Pütz, M. Schindler, Begasungssystem, (2010).","mla":"Frahm, Björn, et al. Begasungssystem. 2010.","bjps":"Frahm B et al. (2010) Begasungssystem.","apa":"Frahm, B., Kauling, J., Pütz, A., & Schindler, M. (2010). Begasungssystem.","ieee":"B. Frahm, J. Kauling, A. Pütz, and M. Schindler, “Begasungssystem.” 2010.","chicago":"Frahm, Björn, Jörg Kauling, Andre Pütz, and Markus Schindler. “Begasungssystem,” 2010."},"application_number":"2010000124 ","alternative_title":["Gassing System"],"ipc":"C12M 1/04 ","ipn":"WO002010083956A2","_id":"2875","date_created":"2020-06-05T14:22:30Z","type":"patent","date_updated":"2023-03-15T13:49:43Z","user_id":"45666"},{"extern":"1","title":"Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration","publication_status":"published","citation":{"ama":"Frahm B, Brod H. Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration.; 2010.","ieee":"B. Frahm and H. Brod, Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration. 2010.","short":"B. Frahm, H. Brod, Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration, 2010.","din1505-2-1":"Frahm, Björn ; Brod, Helmut: Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration, 2010","chicago-de":"Frahm, Björn und Helmut Brod. 2010. Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration.","van":"Frahm B, Brod H. Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration. 2010.","havard":"B. Frahm, H. Brod, Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration, 2010.","mla":"Frahm, Björn, and Helmut Brod. 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(2010). Intensified absorption and distillation devices for modular chemical production processes. Presented at the 19th International Congress of Chemical and Process Engineering, CHISA , Prague, Czech Republic.","chicago":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, and R. Zecirovic. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, 2010.","van":"Dercks B, Frahm B, Grünewald M, Kenig E, Lautenschleger A, Gorak A, et al. Intensified absorption and distillation devices for modular chemical production processes. 2010.","mla":"Dercks, B., et al. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. 2010.","havard":"B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. 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Intensified absorption and distillation devices for modular chemical production processes.","din1505-2-1":"Dercks, B. ; Frahm, Björn ; Grünewald, M. ; Kenig, E. ; Lautenschleger, A. ; Gorak, A. ; Schmidt, P. ; Sudhoff, D. ; u. a.: Intensified absorption and distillation devices for modular chemical production processes, 2010","ieee":"B. Dercks et al., Intensified absorption and distillation devices for modular chemical production processes. 2010.","ama":"Dercks B, Frahm B, Grünewald M, et al. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes.; 2010."},"publication_status":"published","_id":"2913","language":[{"iso":"eng"}],"type":"conference_speech","date_created":"2020-06-10T14:06:06Z","user_id":"45666","date_updated":"2023-03-15T13:49:43Z"},{"intvolume":" 59","user_id":"45666","type":"scientific_journal_article","_id":"2349","doi":"10.1007/s10616-009-9189-9","publication_status":"published","publisher":"Springer","quality_controlled":"1","issue":"1","department":[{"_id":"DEP4021"}],"date_updated":"2023-03-15T13:49:39Z","publication":"Cytotechnology","publication_identifier":{"eissn":["1573-0778"],"issn":["0920-9069"]},"date_created":"2020-05-15T10:17:11Z","language":[{"iso":"eng"}],"oa":"1","volume":59,"citation":{"ieee":"B. Frahm, H. Brod, and U. Langer, “Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration,” Cytotechnology, vol. 59, no. 1, pp. 17–30, 2009.","ama":"Frahm B, Brod H, Langer U. Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology. 2009;59(1):17-30. doi:10.1007/s10616-009-9189-9","chicago":"Frahm, Björn, Helmut Brod, and Uwe Langer. “Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration.” Cytotechnology 59, no. 1 (2009): 17–30. https://doi.org/10.1007/s10616-009-9189-9.","apa":"Frahm, B., Brod, H., & Langer, U. (2009). Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology, 59(1), 17–30. https://doi.org/10.1007/s10616-009-9189-9","ufg":"Frahm, Björn et. al. (2009): Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration, in: Cytotechnology 59 (1), S. 17–30.","havard":"B. Frahm, H. Brod, U. Langer, Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration, Cytotechnology. 59 (2009) 17–30.","mla":"Frahm, Björn, et al. “Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration.” Cytotechnology, vol. 59, no. 1, Springer, 2009, pp. 17–30, doi:10.1007/s10616-009-9189-9.","bjps":"Frahm B, Brod H and Langer U (2009) Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration. Cytotechnology 59, 17–30.","van":"Frahm B, Brod H, Langer U. Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology. 2009;59(1):17–30.","chicago-de":"Frahm, Björn, Helmut Brod und Uwe Langer. 2009. 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Langer, Cytotechnology 59 (2009) 17–30."},"title":"Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration","extern":"1","status":"public","page":"17-30","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677146/","open_access":"1"}],"author":[{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"full_name":"Brod, Helmut","first_name":"Helmut","last_name":"Brod"},{"last_name":"Langer","first_name":"Uwe","full_name":"Langer, Uwe"}],"year":2009},{"extern":"1","title":"Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen","citation":{"short":"A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, (2009).","chicago-de":"Braun, Arndt, Helmut Brod, Björn Frahm, Marc Jenne, Jörg Kauling und Stephan Kirchner. 2009. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.","din1505-2-1":"Braun, Arndt ; Brod, Helmut ; Frahm, Björn ; Jenne, Marc ; Kauling, Jörg ; Kirchner, Stephan: Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen (2009)","ieee":"A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, and S. Kirchner, “Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.” 2009.","apa":"Braun, A., Brod, H., Frahm, B., Jenne, M., Kauling, J., & Kirchner, S. (2009). Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.","chicago":"Braun, Arndt, Helmut Brod, Björn Frahm, Marc Jenne, Jörg Kauling, and Stephan Kirchner. “Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen,” 2009.","ama":"Braun A, Brod H, Frahm B, Jenne M, Kauling J, Kirchner S. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen. 2009.","van":"Braun A, Brod H, Frahm B, Jenne M, Kauling J, Kirchner S. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen. 2009.","bjps":"Braun A et al. (2009) Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen.","havard":"A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen, (2009).","mla":"Braun, Arndt, et al. Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen. 2009.","ufg":"Braun, Arndt et. al. (2009): Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen."},"application_number":"2009004200 ","application_date":"2009-06-10","abstract":[{"lang":"ger","text":"Die Erfindung betrifft eine Vorrichtung und ein Verfahren zur Rückhaltung und Rückführung von Zellen in einem kontinuierlich oder absatzweise durchströmten Gefäß. Ferner betrifft die Erfindung ein Verfahren zur Herstellung einer Vorrichtung, mit dem Zellen in einem kontinuierlich oder absatzweise durchströmten Gefäß zurückgehalten und zurückgeführt werden können. "},{"text":"The invention relates to an apparatus and a method for retaining and recirculating cells in a continuous-flow or batch-flow vessel. The invention further relates to a method for producing an apparatus which allows cells to be retained and recirculated in a continuous-flow or batch-flow vessel.","lang":"eng"}],"department":[{"_id":"DEP4021"}],"year":2009,"author":[{"first_name":"Arndt","full_name":"Braun, Arndt","last_name":"Braun"},{"full_name":"Brod, Helmut","first_name":"Helmut","last_name":"Brod"},{"first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm","id":"45666"},{"full_name":"Jenne, Marc","last_name":"Jenne","first_name":"Marc"},{"first_name":"Jörg","full_name":"Kauling, Jörg","last_name":"Kauling"},{"last_name":"Kirchner","first_name":"Stephan","full_name":"Kirchner, Stephan"}],"publication_date":"200-12-23","page":"35","status":"public","type":"patent","date_created":"2020-06-05T14:07:35Z","date_updated":"2023-03-15T13:49:43Z","user_id":"45666","ipc":"C12M 1/08","alternative_title":["Device for retaining and recirculating cells in a continuous-flow or batch-flow vessel, comprises channels, means for fumigation of external surfaces and/or spaces between the channels, and a generating mean"],"ipn":"WO002009152990A2 ","_id":"2872"},{"type":"conference_speech","date_created":"2020-06-10T14:01:21Z","date_updated":"2023-03-15T13:49:43Z","user_id":"45666","language":[{"iso":"eng"}],"_id":"2912","extern":"1","title":"Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)","publication_status":"published","citation":{"short":"B. 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(2009): Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)."},"department":[{"_id":"DEP4021"}],"conference":{"name":"Industrial Biotechnology Exhibition & Partnering Conference at ACHEMA ","location":"Frankfurt am Main, Germany","end_date":"2009-05-15","start_date":"2009-05-11"},"year":2009,"author":[{"first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn","id":"45666"},{"full_name":"Brod, H.","first_name":"H.","last_name":"Brod"},{"last_name":"Langer","full_name":"Langer, U.","first_name":"U."}],"status":"public"},{"date_created":"2020-06-18T14:21:43Z","type":"conference_poster","date_updated":"2023-03-15T13:49:44Z","user_id":"45666","_id":"2970","language":[{"iso":"eng"}],"extern":"1","title":"Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)","publication_status":"published","citation":{"ama":"Frahm B, Brod H, Langer U. 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Langer, Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA), 2009.","ufg":"Frahm, Björn et. al. (2009): Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA).","van":"Frahm B, Brod H, Langer U. Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). 2009.","chicago":"Frahm, Björn, H. Brod, and U. Langer. Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA), 2009.","apa":"Frahm, B., Brod, H., & Langer, U. (2009). Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). Presented at the 21st Meeting of the European Society for Animal Cell Technology (ESACT): Cellular Solutions for Clinical Challenges, Dublin, Ireland."},"conference":{"end_date":"2009-06-10","start_date":"2009-06-07","location":"Dublin, Ireland","name":"21st Meeting of the European Society for Animal Cell Technology (ESACT): Cellular Solutions for Clinical Challenges"},"department":[{"_id":"DEP4021"}],"year":2009,"author":[{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"},{"last_name":"Brod","full_name":"Brod, H.","first_name":"H."},{"full_name":"Langer, U.","first_name":"U.","last_name":"Langer"}],"status":"public"},{"author":[{"first_name":"W.","full_name":"Van Hecke, W.","last_name":"Van Hecke"},{"first_name":"H.","full_name":"Van Langenhovve, H.","last_name":"Van Langenhovve"},{"last_name":"Frahm","first_name":"Björn","id":"45666","full_name":"Frahm, Björn"},{"last_name":"Brod","first_name":"H.","full_name":"Brod, H."},{"first_name":"J.","full_name":"Dewulf, J.","last_name":"Dewulf"},{"last_name":"Haltrich","first_name":"D.","full_name":"Haltrich, D."},{"last_name":"Ludwig","full_name":"Ludwig, R.","first_name":"R."}],"year":2009,"department":[{"_id":"DEP4021"}],"conference":{"name":"COST 928 Control and exploitation of enzymes for added-value products, 3rd Annual Workshop","location":"Krakow, Poland","start_date":"2009-09-23","end_date":"2009-09-25"},"status":"public","title":"Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor","extern":"1","citation":{"chicago-de":"Van Hecke, W., H. Van Langenhovve, Björn Frahm, H. Brod, J. Dewulf, D. Haltrich und R. Ludwig. 2009. Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor.","din1505-2-1":"Van Hecke, W. ; Van Langenhovve, H. ; Frahm, Björn ; Brod, H. ; Dewulf, J. ; Haltrich, D. ; Ludwig, R.: Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor, 2009","short":"W. Van Hecke, H. Van Langenhovve, B. Frahm, H. Brod, J. Dewulf, D. Haltrich, R. Ludwig, Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor, 2009.","bjps":"Van Hecke W et al. (2009) Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor. .","havard":"W. Van Hecke, H. Van Langenhovve, B. Frahm, H. Brod, J. Dewulf, D. Haltrich, R. Ludwig, Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor, 2009.","mla":"Van Hecke, W., et al. Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor. 2009.","ufg":"Van Hecke, W. et. al. (2009): Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor.","van":"Van Hecke W, Van Langenhovve H, Frahm B, Brod H, Dewulf J, Haltrich D, et al. Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor. 2009.","chicago":"Van Hecke, W., H. Van Langenhovve, Björn Frahm, H. Brod, J. Dewulf, D. Haltrich, and R. Ludwig. Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor, 2009.","apa":"Van Hecke, W., Van Langenhovve, H., Frahm, B., Brod, H., Dewulf, J., Haltrich, D., & Ludwig, R. (2009). 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Hass, Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller, Springer, Dordrecht, 2007."},"volume":"vol. 3","extern":"1","title":"Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller","series_title":"ESACT Proceedings","publisher":"Springer","page":"497-501","status":"public","department":[{"_id":"DEP4021"}],"conference":{"start_date":"2005-06-05","end_date":"2005-06-08","name":"19th ESACT Meeting","location":"Harrogate, UK"},"year":2007,"author":[{"first_name":"Ralf","last_name":"Pörtner","full_name":"Pörtner, Ralf"},{"first_name":"Björn","id":"45666","full_name":"Frahm, Björn","last_name":"Frahm"},{"full_name":"Lane, Paul","last_name":"Lane","first_name":"Paul"},{"last_name":"Munack","first_name":"Axel","full_name":"Munack, Axel"},{"last_name":"Kühn","full_name":"Kühn, Kathrin","first_name":"Kathrin"},{"full_name":"Hass, Volker C.","last_name":"Hass","first_name":"Volker C."}]},{"_id":"2870","ipc":"C12M 1/04 ","alternative_title":["Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten"],"oa":"1","ipn":"DE102006008687A1","user_id":"45666","date_updated":"2023-03-15T13:49:43Z","date_created":"2020-06-05T13:41:13Z","type":"patent","publication_date":"2007-08-30","status":"public","application_date":"2006-02-24","abstract":[{"lang":"eng","text":"The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude and the equivalent number of revolutions. The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude, the equivalent number of revolutions, acceleration of the membrane surface, the delay of the membrane surface, the interruption of the movement or discontinuity. The course of motion is not restricted to recurring samples. The material transfer is increased by mounting of immovable current interfering elements. The disturb of the current forms by the rotatingly oscillating movement of the membrane surfaces. The supply of the membrane surface is undertaken with the help of flexible hoses or turning seals for the supply and discharge of gas. The membrane surface is used for the production of micro-bubbles or gas bubbles in the liquid. Rotor arms rotate in one of the rotation directions curved around the drive shaft. An independent claim is included for a device for gassing of liquid for cell cultures. "},{"text":"Die Erfindung betrifft ein Verfahren und eine Vorrichtung zur blasenfreien Begasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. ","lang":"ger"}],"main_file_link":[{"url":"https://depatisnet.dpma.de/DepatisNet/depatisnet?action=bibdat&docid=DE102006008687A1","open_access":"1"}],"year":2007,"author":[{"first_name":"Helmut","last_name":"Brod","full_name":"Brod, Helmut"},{"first_name":"Björn","last_name":"Frahm","id":"45666","full_name":"Frahm, Björn"},{"full_name":"Kauling, Jörg","first_name":"Jörg","last_name":"Kauling"},{"last_name":"Rose","first_name":"Reinhold","full_name":"Rose, Reinhold"}],"department":[{"_id":"DEP4021"}],"citation":{"ama":"Brod H, Frahm B, Kauling J, Rose R. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component. 2007.","ieee":"H. Brod, B. Frahm, J. Kauling, and R. Rose, “Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.” 2007.","ufg":"Brod, Helmut et. al. (2007): Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.","havard":"H. Brod, B. Frahm, J. Kauling, R. Rose, Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component, (2007).","mla":"Brod, Helmut, et al. Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component. 2007.","bjps":"Brod H et al. (2007) Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component.","van":"Brod H, Frahm B, Kauling J, Rose R. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component. 2007.","chicago":"Brod, Helmut, Björn Frahm, Jörg Kauling, and Reinhold Rose. “Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component,” 2007.","apa":"Brod, H., Frahm, B., Kauling, J., & Rose, R. (2007). Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.","din1505-2-1":"Brod, Helmut ; Frahm, Björn ; Kauling, Jörg ; Rose, Reinhold: Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component (2007)","chicago-de":"Brod, Helmut, Björn Frahm, Jörg Kauling und Reinhold Rose. 2007. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.","short":"H. Brod, B. Frahm, J. Kauling, R. Rose, (2007)."},"application_number":" \t102006008687 ","title":"Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component","extern":"1"},{"status":"public","page":"56","publication_date":"2007-11-01","year":2007,"author":[{"last_name":"Brod","first_name":"Helmut","full_name":"Brod, Helmut"},{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"},{"last_name":"Kauling","first_name":"Jörg","full_name":"Kauling, Jörg"},{"last_name":"Poggel","first_name":"Martin","full_name":"Poggel, Martin"},{"first_name":"Reinhold","last_name":"Rose","full_name":"Rose, Reinhold"},{"first_name":"Sebastian ","full_name":"Schmidt, Sebastian ","last_name":"Schmidt"}],"department":[{"_id":"DEP4021"}],"application_date":"2007-04-23","abstract":[{"lang":"ger","text":"Gegenstand der Erfindung ist ein um seine ortsfeste, bevorzugt vertikale Achse oszillatorischrotierend angetriebener Reaktor für bevorzugt biotechnologische und pharmazeutische Anwendungen. Mit seinen prozessintensivierenden Eigenschaften für das Mischen, das Suspendieren, den Gasstofftransport, die Wärmeübertragung, die Bestrahlung und die Partikelrückhaltung wird die Anwendbarkeit im großtechnischen Maßstab gewährleistet. Der ohne Wellenabdichtung auskommende Reaktor erlaubt eine steriltechnisch besonders robuste Produktion unter Verzicht auf eine Reinigung und Reinigungsvalidierung erfordert, wenn der Reaktor als Einwegreaktor ausgeführt ist. "},{"text":"The subject matter of the invention is a reactor, driven about its fixed, preferably vertical, axis in an oscillatory/rotating manner, for preferably biotechnological and pharmaceutical applications. With its process-intensifying properties for mixing, suspending, gas transport, heat transfer, irradiation and particle retention, the applicability is ensured on a commercial scale. The reactor, which does not need a shaft seal, permits especially robust production with respect to sterile requirements while dispensing with cleaning and cleaning validation if the reactor is designed as a one-way reactor. ","lang":"eng"}],"application_number":"2007003521 ","citation":{"ama":"Brod H, Frahm B, Kauling J, Poggel M, Rose R, Schmidt S. Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. 2007.","ieee":"H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, and S. Schmidt, “Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.” 2007.","chicago-de":"Brod, Helmut, Björn Frahm, Jörg Kauling, Martin Poggel, Reinhold Rose und Sebastian Schmidt. 2007. 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Anwendungsbeispiele veranschaulichen das Potential und die Flexibilität der Steuerung und ihre Universalität bezüglich verschiedener Kultivierungssysteme und Zelllinien. \r\n\r\nDa auch die gelöst-CO2-Konzentration und die Atmungsaktivität der Zellen zunehmend Bedeutung in der Prozessführung erlangen, stellt dieses Buch weiterhin die entwickelte Erfassung dieser Größen per Abgasanalytik und Modellierung des Kohlendioxidtransfers vor.","lang":"ger"}],"department":[{"_id":"DEP4021"}],"year":2003,"author":[{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"}],"publisher":"Books on Demand GmbH","page":"120","status":"public","title":"Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen","publication_status":"published","citation":{"ama":"Frahm B. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH; 2003.","ieee":"B. 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Norderstedt: Books on Demand GmbH.","chicago":"Frahm, Björn. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH, 2003.","short":"B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003.","chicago-de":"Frahm, Björn. 2003. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH.","din1505-2-1":"Frahm, Björn: Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. 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