@misc{12781,
  abstract     = {{Roller compaction/dry granulation (RC/DG) is a key process in pharmaceutical manufacturing for improving powder flowability, density, and segregation resistance. Advanced statistical modeling was used to optimize RC/DG process parameters and subsequently binder compositions by employing process and mixture design experiments. The authors used microcrystalline cellulose (MCC), silicified MCC (SMCC), and dicalcium phosphate (DCP) as filler-binder examples in RC/DG experiments. Granule and tablet properties, including flowability, bulk and tapped densities, as well as resistance to crushing, were analyzed using compendial methods. The process design experiments confirmed that RC/DG reduces manufacturability compared to direct compression. Optimal processing conditions, balancing sufficient tablet strengths and granule formation, were identified to be between 20 (SCF * ϑ) [kN/cm] and ∼ 60 (SCF * ϑ) [kN/cm]. Thereby (ϑ) is defined as the screw-to-roll speed ratio and (SFC) as the specific compaction force. Mixture design experiments revealed optimal mixtures balancing SMCC, MCC, and DCP to achieve desired properties like low angle of repose, high bulk density, and strong tablets. These findings provide guidance for selecting formulations and process parameters in RC/DG applications. The derived ‘SCF * ϑ’- factor was found to effectively describe the granulation intensity. A superimposed mixture design model based on precise target values of the parameters bulk density, flow properties, and breaking force allowed identification of the best formulation.}},
  author       = {{Märkle, Niclas and Warnke, Gernot and Pein-Hackelbusch, Miriam}},
  booktitle    = {{International Journal of Pharmaceutics: X}},
  issn         = {{2590-1567}},
  keywords     = {{Design of experiments, Roller compaction/dry granulation, RC/DG, Dicalcium phosphate, Microcrystalline cellulose, Silicified microcrystalline cellulose}},
  publisher    = {{Elsevier BV}},
  title        = {{{An iterative process and mixture design approach for dry granulated ternary blends of filler-binders}}},
  doi          = {{10.1016/j.ijpx.2025.100331}},
  volume       = {{9}},
  year         = {{2025}},
}

@misc{10216,
  abstract     = {{Wet granulation is a frequent process in the pharmaceutical industry. As a starting point for numerous dosage forms, the quality of the granulation not only affects subsequent production steps but also impacts the quality of the final product. It is thus crucial and economical to monitor this operation thoroughly. Here, we report on identifying different phases of a granulation process using a machine learning approach. The phases reflect the water content which, in turn, influences the processability and quality of the granule mass. We used two kinds of microphones and an acceleration sensor to capture acoustic emissions and vibrations. We trained convolutional neural networks (CNNs) to classify the different phases using transformed sound recordings as the input. We achieved a classification accuracy of up to 90% using vibrational data and an accuracy of up to 97% using the audible microphone data. Our results indicate the suitability of using audible sound and machine learning to monitor pharmaceutical processes. Moreover, since recording acoustic emissions is contactless, it readily complies with legal regulations and presents Good Manufacturing Practices.}},
  author       = {{Fulek, Ruwen and Ramm, Selina and Kiera, Christian and Pein-Hackelbusch, Miriam and Odefey, Ulrich}},
  booktitle    = {{Pharmaceutics}},
  issn         = {{1999-4923 }},
  keywords     = {{wet granulation, acoustic classification, machine learning, convolutional neural networks}},
  number       = {{8}},
  publisher    = {{MDPI}},
  title        = {{{A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions}}},
  doi          = {{https://doi.org/10.3390/pharmaceutics15082153}},
  volume       = {{15}},
  year         = {{2023}},
}

@misc{10788,
  abstract     = {{For process monitoring, an adequate data preprocessing is crucial to link accessible inline process data with offline measured target variables. Literature, however, does not provide systematic preprocessing strategies. The effects of five different preprocessing strategies on data from a Dielectric Spectroscopy system applied to the Viable Cell Density (VCD) of a mammalian cell cultivation were thus evaluated. Single-frequency measurements are typically used to model the VCD over the growth phase using linear regression or the Cole-Cole model and served as a reference. As multi-frequency measurement is promising to model the VCD beyond the growth phase using Partial Least Squares Regression (PLSR), we further aimed to determine, whether replacing linear regression by PLSR shows comparable modeling performance. All five preprocessing strategies led to comparable results. Exemplary, when using capacitance values at a frequency of 3347 kHz, linear regression resulted in a R2 of 0.90 and a standard deviation of 0.4 % on average. Both normalization techniques had the same positive effect on the results of PLSR. The order of smoothing and normalization was irrelevant for both regression methods. Comparing the results of linear regression and PLSR, the latter obtained on average 9 % better results. Therefore, we concluded that PLSR is preferable over linear regression and is potentially suitable to model the VCD beyond the growth phase, which is suggested to be investigated based on more data sets.}},
  author       = {{Ramm, Selina and Hernández Rodriguez, Tanja and Frahm, Björn and Pein-Hackelbusch, Miriam}},
  booktitle    = {{2023 IEEE 21st International Conference on Industrial Informatics (INDIN)}},
  editor       = {{Jasperneite, Jürgen and Wisniewski, Lukasz and Fung Man, Kim}},
  isbn         = {{978-1-6654-9314-7}},
  issn         = {{1935-4576}},
  keywords     = {{Spectroscopy, Smoothing methods, Systematics, Phase measurement, Linear regression, Data models, Dielectric measurement}},
  location     = {{Lemgo}},
  pages        = {{1--6}},
  publisher    = {{IEEE}},
  title        = {{{Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities}}},
  doi          = {{10.1109/INDIN51400.2023.10218012}},
  year         = {{2023}},
}

@misc{9627,
  author       = {{Ramm, Selina and Fulek, Ruwen and Eberle, Veronika Anna and Kiera, Christian and Odefey, Ulrich and Pein-Hackelbusch, Miriam}},
  location     = {{Rosenberg}},
  title        = {{{Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation}}},
  year         = {{2023}},
}

@misc{12897,
  abstract     = {{Glove occlusion might enhance skin sensitivity to a subsequent detergent challenge (occlusion effect). Thus, some skin protection creams (PC) claim to protect against this effect of occlusion, and are recommended to be used before wearing liquid‐proof gloves.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>To evaluate the effect of PC applied prior to glove occlusion on the ‘occlusion effect’—refers to increased susceptibility of the skin to a model detergent.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>One hundred and eleven volunteers were enrolled in a single‐blind, randomized study. Seven PCs were applied before glove occlusion over 7 days (D1–D7). After sodium lauryl sulphate (SLS) challenge, we compared the irritation between the areas treated with PC and occlusion alone. Clinical scoring and bioengineering methods (capacitance, transepidermal water loss [TEWL], and colourimetry [erythema]) were used to quantify the irritant reactions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>After 1 week of occlusion and PC application, we did not observe significant changes in TEWL, nor in erythema, whereas skin hydration raised in three cream‐treated areas. On day 10, after a challenge with SLS, some products significantly aggravated the skin irritation as compared to occlusion alone.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The ‘occlusion effect’—shown as higher skin susceptibility to a model detergent—was not mitigated by PCs when applied prior to glove occlusion. On the contrary, some PCs might have negative effects on skin barrier function and augment such sensitivity.}},
  author       = {{Gina, Michal and Wichert, Katharina and Kutz, Gerd and Brüning, Thomas and Fartasch, Manigé}},
  booktitle    = {{Contact dermatitis : environmental and occupational dermatitis}},
  issn         = {{1600-0536}},
  keywords     = {{barrier disturbance, glove occlusion, irritant contact dermatitis, irritation, non-invasive measuring methods, occupational contact dermatitis, skin barrier disturbance, skin protective cream, wet work.}},
  number       = {{5}},
  pages        = {{372--382}},
  publisher    = {{Wiley}},
  title        = {{{Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study}}},
  doi          = {{10.1111/cod.14287}},
  volume       = {{88}},
  year         = {{2023}},
}

@misc{9568,
  abstract     = {{Pellet production is a multi-step manufacturing process comprising granulation, extrusion and spheronisation. The first step represents a critical control point, since the quality of the granule mass highly influences subsequent process steps and, consequently, the quality of final pellets. The most important parameter of wet granulation is the liquid requirement, which can often only be quantitatively evaluated after further process steps. To identify an alternative for optimal liquid requirements, experiments were conducted with a formulation based on lactose and microcrystalline cellulose. Granules were analyzed with a Powder Vertical Shear Rig. We identified the compression density (ρpress) as the said alternative, linking information from the powder material and the moisture content (R2 = 0.995). We used ρpress to successfully predict liquid requirements for unknown formulation compositions. By means of this prediction, pellets with high quality, regarding shape and size distribution, were produced by carrying out a multi-step manufacturing process. Furthermore, the applicability of ρpress as an alternative quality parameter to other placebo formulations and to formulations containing active pharmaceutical ingredients (APIs) was demonstrated.}},
  author       = {{Ramm, Selina and Fulek, Ruwen and Eberle, Veronika Anna and Kiera, Christian and Odefey, Ulrich and Pein-Hackelbusch, Miriam}},
  booktitle    = {{Pharmaceutics}},
  issn         = {{1999-4923}},
  keywords     = {{wet granulation, liquid requirement, granulation endpoint, compression density}},
  number       = {{11}},
  publisher    = {{MDPI}},
  title        = {{{Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation.}}},
  doi          = {{https://doi.org/10.3390/pharmaceutics14112303}},
  volume       = {{14}},
  year         = {{2022}},
}

@inproceedings{2879,
  author       = {{Kutz, Gerd and Repka, M. and Thipsay, P.}},
  location     = {{Granada (Spanien)}},
  title        = {{{Impact of formulation and process parameters in twin screw hot-melt granulation coupled with in-line particle size analysis of sustained release HPMC granules}}},
  year         = {{2018}},
}

@inproceedings{2881,
  author       = {{Kutz, Gerd and Daniels, R. and Kamke, Dominic}},
  location     = {{Granada (Spanien)}},
  title        = {{{Real time control of melt granulation processes by inline measurement of particle size}}},
  year         = {{2018}},
}

@inproceedings{2883,
  author       = {{Kutz, Gerd and Schlebach, Simon and Kamke, Dominic}},
  location     = {{Granada (Spanien)}},
  title        = {{{Fluid bed drying – Characterization by DoE}}},
  year         = {{2018}},
}

@misc{12139,
  author       = {{Daniels, R. and Kamke, Dominic and Kutz, Gerd}},
  location     = {{San Diego (USA)}},
  title        = {{{An Innovative Tool For Real-Time Particle Size Measurement During High-Shear Melt Granulation}}},
  year         = {{2017}},
}

@misc{12140,
  author       = {{Thipsay, P. and Bookwala, M. and Kutz, Gerd and Repka, M. and Ye, X.}},
  location     = {{San Diego (USA).}},
  title        = {{{Effect of Different HPMC Grades and Process Parameters on Physic-Chemical Properties of Sustained Release Matrix Granules Prepared via Twin Screw Melt Granulation}}},
  year         = {{2017}},
}

@misc{12141,
  author       = {{Thipsay, P. and Kutz, Gerd and Repka, M.}},
  location     = {{San Diego (USA)}},
  title        = {{{In-Line Particle Size Analysis of Sustained Release HPMC Matrix Granules to Study the Impact of Formulation and Process Parameters in Twin Screw Hot-Melt Granulation}}},
  year         = {{2017}},
}

@misc{12142,
  author       = {{Vo, A. and Kamke, Dominic and Kim, D. and Martin, S. and Repka, M. and Kutz, Gerd}},
  location     = {{San Diego (USA)}},
  title        = {{{Inline Particle Size Analysis to Monitor in Real Time Continuous Melt Extruded Pelletization}}},
  year         = {{2017}},
}

@misc{12143,
  author       = {{Vo, A. and Kutz, Gerd and He, H. and Zang, J. and Kim, D. and Kim, S. and Repka, M.}},
  location     = {{San Diego (USA)}},
  title        = {{{Continuous Manufacturing of NSAID Delayed Release Pellets by Hot Melt Extrusion Technology: Application of QbD Space Design, Inline FT-NIR, and Inline Pellet Size Analysis}}},
  year         = {{2017}},
}

@misc{12144,
  author       = {{Kamke, Dominic and Scherbaum, B. and Daniels, R. and Kutz, Gerd}},
  location     = {{Krakau}},
  title        = {{{One formulation, four granulation techniques - Comparison of energy consumption}}},
  year         = {{2017}},
}

@article{2885,
  author       = {{Kutz, Gerd}},
  issn         = {{0938-2216}},
  journal      = {{Haut}},
  number       = {{6}},
  pages        = {{324--329}},
  publisher    = {{WPV, Wirtschafts- und Praxisverlag GmbH }},
  title        = {{{Zur Galenik topischer Lichtschutzmittel  Haut}}},
  volume       = {{XXVVIII}},
  year         = {{2017}},
}

@inproceedings{3326,
  author       = {{Kutz, Gerd}},
  location     = {{Nürnberg}},
  title        = {{{Überwachung von Schmelz- und Feuchtgranulationsprozessen in Intensivmischern mit Hilfe der Parsum-Sonde}}},
  year         = {{2017}},
}

@inproceedings{3329,
  author       = {{Kutz, Gerd}},
  booktitle    = {{Teil 11: Symposium der GD Task Force „Licht.Hautkrebs.Prävention“: Prävention von hellem Hautkrebs im privaten und im beruflichen Bereich}},
  location     = {{München}},
  title        = {{{Galenik von aktuellen topischen Lichtschutzmitteln}}},
  year         = {{2017}},
}

@misc{12038,
  author       = {{Kamke, Dominic and Kutz, Gerd and Daniels, R. and Dietrich, S.}},
  location     = {{Glasgow (Großbritannien)}},
  title        = {{{Performance qualification of an inline particle sizing probe}}},
  year         = {{2016}},
}

@inproceedings{4459,
  author       = {{Kutz, Gerd}},
  location     = {{Köln}},
  title        = {{{APV basics}}},
  year         = {{2016}},
}

@article{3331,
  author       = {{Kutz, Gerd and Kamke, Dominic}},
  issn         = {{2191-8341}},
  journal      = {{TechnoPharm : making science work}},
  number       = {{5}},
  pages        = {{290--294}},
  publisher    = {{ECV}},
  title        = {{{ Innovativer Ansatz zur Prozesskontrolle bei der Granulation im Intensivmischergranulator (Teil 2)}}},
  volume       = {{6}},
  year         = {{2016}},
}

@article{3332,
  author       = {{Kutz, Gerd and Kamke, Dominic}},
  issn         = {{2191-8341}},
  journal      = {{TechnoPharm : making science work }},
  number       = {{4}},
  pages        = {{234--239}},
  publisher    = {{ECV}},
  title        = {{{Innovativer Ansatz zur Prozesskontrolle bei der Granulation im Intensivmischergranulator (Teil 1)}}},
  volume       = {{6}},
  year         = {{2016}},
}

@inproceedings{3333,
  author       = {{Kutz, Gerd}},
  location     = {{Köln}},
  publisher    = {{TÜV Rheinland LGA Products GmbH}},
  title        = {{{Anforderungen an die aseptische Herstellung}}},
  year         = {{2016}},
}

@inproceedings{3341,
  author       = {{Kutz, Gerd}},
  location     = {{Köln}},
  publisher    = {{TÜV Rheinland LGA Products GmbH}},
  title        = {{{Sterilfiltration}}},
  year         = {{2016}},
}

@inproceedings{3395,
  author       = {{Kutz, Gerd}},
  location     = {{Köln}},
  publisher    = {{TÜV Rheinland LGA Products GmbH}},
  title        = {{{Filterintegritätstests }}},
  year         = {{2016}},
}

@inproceedings{3396,
  author       = {{Kutz, Gerd}},
  location     = {{TÜV Rheinland LGA Products GmbH in Köln.}},
  title        = {{{Sterilisations- und Desinfektionsverfahren}}},
  year         = {{2016}},
}

@inproceedings{3397,
  author       = {{Kutz, Gerd}},
  location     = {{TÜV Rheinland LGA Products GmbH in Köln}},
  title        = {{{Media Fill - Prozesssimulation mit Nährmedien}}},
  year         = {{2016}},
}

@inproceedings{3416,
  author       = {{Kutz, Gerd}},
  location     = {{Bonn}},
  title        = {{{Messmethoden (sichtbare Partikel), Methoden des Ph. Eur}}},
  year         = {{2016}},
}

@inproceedings{3417,
  author       = {{Kutz, Gerd}},
  location     = {{Tübingen}},
  title        = {{{Qualifizierung, Kalibrierung, Reinigungsvalidierung, Prozessparameter, Prozessvalidierung}}},
  year         = {{2016}},
}

@article{3418,
  author       = {{Kutz, Gerd and Kamke, Dominic}},
  issn         = {{1434-8942 }},
  journal      = {{  Pharma + Food : Effizienz im Hygieneprozess : Ausrüstung, Produktion, Organisation}},
  number       = {{4}},
  pages        = {{36--38}},
  publisher    = {{Hüthig}},
  title        = {{{Dem Intensivmischer auf der Spur: Echtzeit- Prozesskontrolle}}},
  year         = {{2016}},
}

@inproceedings{4460,
  author       = {{Kutz, Gerd and Schubert, O. E.}},
  location     = {{Hochschule Ostwestfalen-Lippe Detmold}},
  title        = {{{APV basics}}},
  year         = {{2015}},
}

@inproceedings{4461,
  author       = {{Kutz, Gerd and Schubert, O. E.}},
  location     = {{Darmstadt}},
  title        = {{{APV basics}}},
  year         = {{2015}},
}

@inproceedings{3422,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Filterintegritätstests}}},
  year         = {{2015}},
}

@inproceedings{3423,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Sterilfiltration}}},
  year         = {{2015}},
}

@inproceedings{3424,
  author       = {{Kutz, Gerd}},
  location     = {{Tübingen}},
  title        = {{{Neue Ansätze zur Prozessvalidierung und Prozesssteuerung: Herstellungsprozesse im Spiegel von EMA-, FDA-, ICH- und PIC/S- Empfehlungen}}},
  year         = {{2015}},
}

@inproceedings{3425,
  author       = {{Kutz, Gerd}},
  location     = {{Darmstadt}},
  title        = {{{Allgemeine Grundlagen zu Hitzesterilisationsverfahren}}},
  year         = {{2015}},
}

@inproceedings{3426,
  author       = {{Kutz, Gerd}},
  location     = {{Darmstadt}},
  title        = {{{Physikalische Grundlagen der Dampfsterilisation}}},
  year         = {{2015}},
}

@inproceedings{3427,
  author       = {{Kutz, Gerd}},
  location     = {{Bonn}},
  title        = {{{Überblick über Messmethoden und deren physikalischen Hintergründe: Sichtbare Partikel}}},
  year         = {{2015}},
}

@misc{12145,
  author       = {{Hüttner, C. and Kutz, Gerd and Dietrich, S. }},
  location     = {{Graz (Österreich)}},
  title        = {{{PAT in High-Shear Granulation Processes using In-line Particle Size Measurements}}},
  year         = {{2014}},
}

@misc{12146,
  author       = {{Hüttner , C. and Türken, B. and Kutz, Gerd and Dietrich, Stefan}},
  location     = {{Lissabon (Portugal)}},
  title        = {{{Real time process control during wet granulation in a high-shear mixer using Spatial Filter Velocimetry - Influence of different formulations }}},
  year         = {{2014}},
}

@misc{12157,
  author       = {{Lewandowski, E. and Kamke, Dominic and Kutz, Gerd and Dietrich, S.}},
  location     = {{Lissabon (Portugal)}},
  title        = {{{Real time particle size measurement during high-shear melt granulation}}},
  year         = {{2014}},
}

@inproceedings{4403,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Emulsionen im Spiegel von ICH- und PIC/S-Empfehlungen}}},
  year         = {{2014}},
}

@inproceedings{4404,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Rohstoffe und Formulierungsstrategien}}},
  year         = {{2014}},
}

@inproceedings{4405,
  author       = {{Kutz, Gerd}},
  location     = {{Nürnberg }},
  title        = {{{Sterilisierung und Desinfektion im Life Science Bereich}}},
  year         = {{2014}},
}

@inproceedings{4434,
  author       = {{Kutz, Gerd}},
  keywords     = {{Scientific lecture and workshop}},
  location     = {{Paris (Frankreich)}},
  title        = {{{Formulation for better efficacy}}},
  year         = {{2014}},
}

@inproceedings{4462,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{APV basics}}},
  year         = {{2014}},
}

@inbook{2632,
  author       = {{Kutz, Gerd and Pohlmann, Döthe and Wiebe, Viktor}},
  booktitle    = {{Apothekenrezeptur und -defektur: Herstellung von Arzneimitteln und Körperpflegemitteln }},
  editor       = {{Thoma, Karl and Daniels, Rolf}},
  isbn         = {{978-3-7692-5881-3}},
  publisher    = {{Dt. Apotheker-Verl. }},
  title        = {{{Haut- und Körperpflegemittel}}},
  volume       = {{Kapitel 4}},
  year         = {{2014}},
}

@article{2634,
  author       = {{Kutz, Gerd and Walger, Tatjana and Feiler, Stefanie and Solot, Philippe}},
  issn         = {{1434-8942}},
  journal      = {{Pharma + Food}},
  number       = {{3}},
  pages        = {{90 -- 92}},
  publisher    = {{Hüthig }},
  title        = {{{Den Designspace definieren : Bessere Prozesskenntnisse erleichtern die Validierung}}},
  volume       = {{12}},
  year         = {{2014}},
}

@article{2636,
  author       = {{Kutz, Gerd and Felbusch, Natalja and Feiler, Stefanie and Solot, Philippe}},
  issn         = {{2198-0691 }},
  journal      = {{Prozesstechnik : das Fachmagazin für die gesamte Prozessindustrie ; Chemie, Pharma, Food}},
  number       = {{8}},
  pages        = {{54 -- 55}},
  publisher    = {{Fachwelt-Verl. }},
  title        = {{{Schnelle Identifikation wichtiger Parameter mittels Versuchsplanung : Zwei auf einen Streich}}},
  volume       = {{43}},
  year         = {{2014}},
}

@article{2669,
  author       = {{Kutz, Gerd and Kamke, Dominik}},
  issn         = {{1616-7074}},
  journal      = {{Die pharmazeutische Industrie : pharmind ; europharm ; Veröffentlichungen über sämtliche Aspekte der Herstellung und des Vertriebes pharmazeutischer Erzeugnisse ; Forum der Pharma-Industrie für alle Themen der Pharma-, Gesundheits- und Sozialpolitik sowie des Arzneimittelwesens im Umfeld der Marktbeteiligten ; Mitteilungsorgan der Verbände der Pharma-Industrie in Deutschland, Österreich und in der Schweiz}},
  number       = {{9}},
  pages        = {{1510 -- 1518}},
  publisher    = {{Editio-Cantor-Verl. für Medizin und Naturwiss. }},
  title        = {{{Grundlagen der Sterilfiltration in der pharmazeutischen Industrie}}},
  volume       = {{75}},
  year         = {{2013}},
}

@inproceedings{3629,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Filterintegritätstests}}},
  year         = {{2013}},
}

@inproceedings{3630,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Sterilfiltration}}},
  year         = {{2013}},
}

@misc{12041,
  author       = {{Kamke, Dominic and Bennyassine, A. and Kutz, Gerd and Meier, S.}},
  location     = {{Istanbul (Türkei)}},
  title        = {{{Investigation of Film Coating Processes in an Innojet Air Coater (IAC 025) using two Coating Formulations}}},
  year         = {{2012}},
}

@misc{12044,
  author       = {{Kellner, Theresa and Kamke, Dominic and Kutz, Gerd and Dietrich , S.}},
  location     = {{Istanbul (Türkei)}},
  title        = {{{Continuous In-Line Particle Sizing during High-Shear Granulation for Process Control}}},
  year         = {{2012}},
}

@misc{12045,
  author       = {{Kutz, Gerd}},
  location     = {{München}},
  title        = {{{Cosmetic formulations workshop}}},
  year         = {{2012}},
}

@inproceedings{4468,
  author       = {{Kutz, Gerd and Schubert, O. E.}},
  location     = {{Detmold}},
  title        = {{{APV basics}}},
  year         = {{2012}},
}

@inproceedings{4469,
  author       = {{Kutz, Gerd}},
  booktitle    = {{Praktikum: Emulsionen – Weiterbildung an der Hochschule Ostwestfalen-Lippe}},
  location     = {{Detmold}},
  title        = {{{APV basics}}},
  year         = {{2012}},
}

@article{2665,
  author       = {{Kutz, Gerd and Anna Skala, Monika and Feldbusch, Natalja and Perlich, Dennis}},
  issn         = {{1616-7074}},
  journal      = {{Die pharmazeutische Industrie : pharmind ; europharm}},
  number       = {{4}},
  pages        = {{630 -- 636}},
  publisher    = {{Editio-Cantor-Verl. für Medizin und Naturwiss.}},
  title        = {{{Systematische Untersuchung zur Prozessvalidierung ethoxylathaltiger Emulsionssysteme}}},
  volume       = {{74}},
  year         = {{2012}},
}

@inproceedings{3632,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Emulsionen im Spiegel von ICH- und PIC/S-Empfehlungen}}},
  year         = {{2012}},
}

@inproceedings{3633,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Rohstoffe und Formulierungsstrategien}}},
  year         = {{2012}},
}

@book{3517,
  abstract     = {{Das Werk vermittelt kompakt und praxisnah Grundlagenwissen. Behandelt werden die Themenbereiche Rohstoffe und Systematik, die unterschiedlichen Herstellprozesse sowie Prüfungen auf chemische, physikalische und mikrobiologische Stabilität.Es ist auch ein Kapitel zur biopharmazeutischen Charakterisierung enthalten.}},
  author       = {{Kutz, Gerd and Daniels, Rolf and Trommer, Hagen}},
  isbn         = {{978-3-87193-398-1}},
  pages        = {{208}},
  publisher    = {{ECV, Editio-Cantor-Verl. }},
  title        = {{{Emulsionen – Entwicklung, Herstellung, Prüfung}}},
  volume       = {{3}},
  year         = {{2011}},
}

@article{3518,
  author       = {{Kutz, Gerd and Hausschild, N. and Skala, M. A. }},
  issn         = {{2191-8341}},
  journal      = {{TechnoPharm : making science work}},
  number       = {{2}},
  pages        = {{136--143}},
  publisher    = {{ECV, Editio-Cantor-Verl.}},
  title        = {{{Statistische Versuchsplanung zur Festlegung von Prozessparametern bei Filmüberzugsverfahren im Vertical Centrifugel Coater 3-15}}},
  volume       = {{1}},
  year         = {{2011}},
}

@misc{12046,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Filterintegritätstestung}}},
  year         = {{2010}},
}

@misc{12050,
  author       = {{Hauschildt, N. and Skala, Monika Anna and Kutz, Gerd and Falck, H. }},
  location     = {{7th World Meeting on Pharmaceutics Biopharmaceutics and Pharmaceutical Technology}},
  title        = {{{Optimisation of film coating processes in a vertical centifugal coater by using design of experiments }}},
  year         = {{2010}},
}

@misc{12051,
  author       = {{Kutz, Gerd and Perlich, D.}},
  location     = {{Valletta (Malta)}},
  title        = {{{One Formulation - Two dosage forms: Processparameters determine the structure of emulsified systems}}},
  year         = {{2010}},
}

@misc{12052,
  author       = {{Feldbusch, Natalja and Kutz, Gerd}},
  location     = {{Valletta (Malta)}},
  title        = {{{Design of experiments as an effective tool to characterize relevant parameters during the production of disperes systems}}},
  year         = {{2010}},
}

@article{4435,
  author       = {{Feldbusch, Natalja and Kutz, Gerd and Feiler, Stefanie and Solot, Philippe}},
  issn         = {{0009-2800 }},
  journal      = {{Chemie, Anlagen, Verfahren : CAV ; die Zeitschrift für Chemie- und Pharmatechnik }},
  number       = {{8}},
  pages        = {{54--55}},
  publisher    = {{Konradin-Verl. Kohlhammer }},
  title        = {{{Zwei auf einen Streich - Schnelle Identifikation wichtiger Parameter mittels Versuchsplanung}}},
  volume       = {{43}},
  year         = {{2010}},
}

@misc{4436,
  author       = {{Antonov, D. and Seyfarth, F. and Schliemann, S. and Terhaer, F. and Bock, M. and John, S. M. and Kleesz, P. and Pohlmann, D. and Kutz, Gerd and Elsner, P.}},
  booktitle    = {{Dermatologie in Beruf und Umwelt}},
  issn         = {{1616-7090}},
  number       = {{Nr. 2}},
  pages        = {{S. 90}},
  publisher    = {{Dustri-Verlag Dr. Karl Feistle GmbH}},
  title        = {{{Development of a test model for occupational hand-cleansers to quantify cleansing efficacy in relation to irritant otential}}},
  volume       = {{58}},
  year         = {{2010}},
}

@inproceedings{4472,
  author       = {{Kutz, Gerd}},
  location     = {{Hochschule-Ostwestfalen Detmold}},
  title        = {{{Emulsionen}}},
  year         = {{2010}},
}

@inproceedings{4473,
  author       = {{Kutz, Gerd}},
  location     = {{Hochschule Ostwestfalen-Lippe Detmold}},
  title        = {{{Praktikum: Aseptisches Arbeiten}}},
  year         = {{2010}},
}

@article{2630,
  abstract     = {{The anaplerotic odd-medium-chain triglyceride triheptanoin is used in clinical trials for the chronic dietary treatment of patients with long-chain fatty acid oxidation disorders. We previously showed (Kinman RP, Kasumov T, Jobbins KA, Thomas KR, Adams JE, Brunengraber LN, Kutz G, Brewer WU, Roe CR, Brunengraber H. Am J Physiol Endocrinol Metab 291: E860–E866, 2006) that the intravenous infusion of triheptanoin increases lipolysis traced by the turnover of glycerol. In this study, we tested whether lipolysis induced by triheptanoin infusion is accompanied by the potentially harmful release of long-chain fatty acids. Rats were infused with heptanoate ± glycerol or triheptanoin. Intravenous infusion of triheptanoin at 40% of caloric requirement markedly increased glycerol endogenous Ra but not oleate endogenous Ra. Thus, the activation of lipolysis was balanced by fatty acid reesterification in the same cells. The liver acyl-CoA profile showed the accumulation of intermediates of heptanoate β-oxidation and C5-ketogenesis and a decrease in free CoA but no evidence of metabolic perturbation of liver metabolism such as propionyl overload. Our data suggest that triheptanoin, administered either intravenously or intraduodenally, could be used for intensive care and nutritional support of metabolically decompensated long-chain fatty acid oxidation disorders.}},
  author       = {{Gu, Lei and Zhang, Guo-Fang and  Kombu, Rajan S.  and Allen, Frederick and Kutz, Gerd and Brewer, Brewer and Roe, Charles R. and Brunengraber, Henri}},
  issn         = {{1522-1555}},
  journal      = {{American journal of physiology : Endocrinology and metabolism}},
  number       = {{2}},
  pages        = {{E362 -- E371}},
  publisher    = {{APS}},
  title        = {{{Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA profile}}},
  doi          = {{https://doi.org/10.1152/ajpendo.00384.2009}},
  volume       = {{298}},
  year         = {{2010}},
}

@inproceedings{2711,
  author       = {{Kutz, Gerd}},
  title        = {{{Formulierungskonzepte für Emulsionen - ausgewählte Beispiele : Emulsionen -Formulierung Herstellung Charakterisierung}}},
  year         = {{2010}},
}

@inproceedings{2729,
  author       = {{Kutz, Gerd and Walger, T.}},
  location     = {{Valletta (Malta)}},
  title        = {{{Optimisation of a Film Coating Process using Design of Experiments}}},
  year         = {{2010}},
}

@inproceedings{3519,
  abstract     = {{Praktikum: Emulsionen}},
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Rohstoffe und Formulierungsstrategien}}},
  year         = {{2010}},
}

@inproceedings{3543,
  author       = {{Kutz, G}},
  location     = {{Detmold}},
  title        = {{{Sterilfiltration}}},
  year         = {{2010}},
}

@misc{12255,
  abstract     = {{Vorgeschlagen wird eine Vorrichtung zum Testen von kosmetischen und pharmazeutischen Rohstoffen beinhaltend eine Membran, die über ein Behältnis gespannt wird, welches ein Hydrogel als tragenden Untergrund für die Membran enthält. }},
  author       = {{Bruns, Christiane and Kutz, Gerd and Prinz, Daniela}},
  pages        = {{1}},
  title        = {{{Hautmodell}}},
  year         = {{2009}},
}

@inproceedings{3981,
  author       = {{Kutz, Gerd}},
  location     = {{Amman (Jordanien)}},
  title        = {{{Current Emulsification Techniques}}},
  year         = {{2009}},
}

@inbook{3985,
  author       = {{Kutz, Gerd}},
  booktitle    = {{Innovationen : Herausforderungen und Chancen}},
  isbn         = {{978-3-87846-271-2}},
  publisher    = {{Verlag für chemische Industrie}},
  title        = {{{Aktuelle Rohstoffe und Formulierungsstrategien}}},
  volume       = {{33}},
  year         = {{2009}},
}

@article{2637,
  abstract     = {{Anaplerotic TH (glycerol triheptanoate) is used for the chronic oral treatment of long-chain fatty acid oxidation disorders (FOD). To test whether TH could also be used for the acute intravenous treatment of decompensated FOD patients, we investigated the metabolism and metabolic effects of triheptanoin emulsion administered parenterally or enterally. Rats were infused with TH emulsion (intravenously or intragastrically). Stable isotope tracers were infused intravenously to measure the rates of appearance (Ra) of plasma glucose, glycerol and fatty acids. Surprisingly, intravenous infusion of triheptanoin markedly increased glycerol Ra but not oleate Ra. This indicated that massive lipolysis induced by intravenous TH was not accompanied by the release of long-chain fatty acids from adipocytes. This probably results from the contribution of anaplerotic propionyl-CoA moiety of heptanoate to glyceroneogenesis in adipocytes, generating sufficient amounts of glycerol-3-phosphate to re-esterify the fatty acids derived from stimulated lipolysis. The intraduodenal infusion of TH did not induce lipolysis because TH was hydrolyzed in the gut. Our data support the use of intravenous TH emulsion for the acute treatment of FOD patients (for whom the release of fatty acids from adipocytes would be harmful). Supported by NIH.}},
  author       = {{Gu, Lei and Zhang, Guofang and S. Kombu, Rajan and Kutz, Gerd and Brewer, Wolf-Ulrich and Roe, Charles R. and Brunengraber, Henri}},
  issn         = {{1530-6860}},
  journal      = {{  The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology}},
  number       = {{4}},
  pages        = {{506.3}},
  publisher    = {{Wiley}},
  title        = {{{Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal rats}}},
  doi          = {{ https://doi.org/10.1096/fasebj.23.1_supplement.506.3}},
  volume       = {{23}},
  year         = {{2009}},
}

@misc{12056,
  author       = {{Kutz, Gerd and Liping, L. and Li, D.}},
  location     = {{Barcelona (Spanien)}},
  title        = {{{Process analysis of fluid bed granulation using risk assessment and design of experiments}}},
  year         = {{2008}},
}

@misc{12158,
  author       = {{Kutz, Gerd and Walger, T.}},
  location     = {{Barcelona (Spanien)}},
  title        = {{{Optimisation of a film Coating process using design of experiments}}},
  year         = {{2008}},
}

@inproceedings{3982,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Rohstoffe in Emulsionen}}},
  year         = {{2008}},
}

@article{3984,
  author       = {{Kutz, Gerd}},
  issn         = {{0942-7694}},
  journal      = {{SOFW-Journal : Home & personal care ingredients & formulations; Deutsche Ausgabe}},
  number       = {{9}},
  pages        = {{70--78}},
  publisher    = {{Verl. für Chemische Industrie, Ziolkowsky}},
  title        = {{{Aktuelle Rohstoffe und Formulierungsstrategien}}},
  volume       = {{134}},
  year         = {{2008}},
}

@inproceedings{3987,
  author       = {{Kutz, Gerd and Walger, T. and Feiler, S. and Solot, P.}},
  location     = {{Stoos (Schweiz)}},
  title        = {{{Optimisation of a film coating process using design of experiments}}},
  year         = {{2008}},
}

@inproceedings{3990,
  author       = {{Kutz, Gerd}},
  location     = {{Karlsruhe}},
  title        = {{{Pharmazeutische Emulsionen}}},
  year         = {{2008}},
}

@inproceedings{3991,
  author       = {{Kutz, Gerd}},
  location     = {{Tübingen}},
  title        = {{{Neue Rohstoffe und Formulierungsstrategien}}},
  year         = {{2008}},
}

@misc{12057,
  author       = {{Kutz, Gerd and Petrovic, S. and Walter, Marius}},
  location     = {{Nürnberg}},
  title        = {{{Re-Qualification of a fluid bed coater Type HCK 300TJ}}},
  year         = {{2007}},
}

@misc{12058,
  author       = {{Brauer, I. and Kutz, Gerd}},
  location     = {{Nürnberg}},
  title        = {{{Investigatioons regarding qualification and process validation of components of packaging lines}}},
  year         = {{2007}},
}

@misc{12070,
  author       = {{Kutz, Gerd and Salzmann, Volker and Weber, M.}},
  location     = {{Nürnberg}},
  title        = {{{Investigation regarding high shear homogenization as an alternative füor the production of submicron lipid particles}}},
  year         = {{2007}},
}

@inproceedings{3992,
  author       = {{Kutz, Gerd}},
  location     = {{Moskau (Russland)}},
  title        = {{{Emulsification by rotor/stator- and rotor/systems}}},
  year         = {{2007}},
}

@inbook{3995,
  author       = {{Kutz, Gerd and Wolff, A.}},
  booktitle    = {{Pharmazeutische Produkte und Verfahren}},
  editor       = {{Kutz, Gerd and Wolff, Armin }},
  isbn         = {{978-3-527-31222-1}},
  pages        = {{1--4}},
  publisher    = {{WILEY-VCH}},
  title        = {{{Einführung}}},
  doi          = {{10.1002/9783527611133.ch1}},
  year         = {{2007}},
}

@inproceedings{4034,
  author       = {{Kutz, Gerd}},
  location     = {{Moskau ( Russland)}},
  title        = {{{Skin care formulations - from scratch to current applications}}},
  year         = {{2007}},
}

@inproceedings{4038,
  author       = {{Kutz, Gerd}},
  location     = {{Basel (Schweiz)}},
  title        = {{{Formulierungskonzepte für Emulsionen - ausgewählte Beispiele}}},
  year         = {{2007}},
}

@book{2735,
  abstract     = {{Dieses Buch bietet einen umfassenden Überblick über die Anforderungen an pharmazeutische Produkte und Herstellungsverfahren. Es beschreibt detailliert die Prozesse, Produktionstechniken und -anlagen sowie die begleitenden Qualifizierungs- und Validierungsmaßnahmen.
}},
  editor       = {{Kutz, Gerd and Wolff, Armin}},
  isbn         = {{978-3-527-31222-1}},
  pages        = {{445}},
  publisher    = {{Wiley-VCH-Verl. }},
  title        = {{{Pharmazeutische Produkte und Verfahren}}},
  doi          = {{10.1002/9783527611133}},
  year         = {{2007}},
}

@misc{12059,
  author       = {{Kutz, Gerd and Bruns, Christina and Salzmann, Volker}},
  location     = {{Lyon (Frankreich)}},
  title        = {{{Comparative studies on emulsion preparation using different processing facilities}}},
  year         = {{2006}},
}

@misc{12061,
  author       = {{Kutz, Gerd and Bruns, Christina and Enga, M. and Hening, S.}},
  location     = {{Lyon (Frankreich)}},
  title        = {{{Current food ingredients in cosmetic formulations and their effects on relevant skin parameters}}},
  year         = {{2006}},
}

@misc{12062,
  author       = {{Kutz, Gerd and Bruns, Christina and Hennigs, Sören and Enga, M.}},
  location     = {{Genf}},
  title        = {{{Current ingredients in semi-solid formulations and their effects on skin hydration, transepidermal water loss and water resistance}}},
  year         = {{2006}},
}

@misc{12063,
  author       = {{Kutz, Gerd}},
  location     = {{Nürnberg}},
  title        = {{{Galenical Characterisation of Skin Care Products}}},
  year         = {{2006}},
}

@misc{12065,
  author       = {{Kutz, Gerd and Salzmann, Volker and Bruns, Christina and Lewandrowski, A.}},
  location     = {{Genf}},
  title        = {{{Comparative studies on processing facilities with special regard to the new Co-Twister System }}},
  year         = {{2006}},
}

@misc{12067,
  author       = {{Bruns, Christina and Müller, R. H.  and Prinz, D. and Kutz, Gerd}},
  location     = {{Genf}},
  title        = {{{Identification of topical excipients with high performance spreadabilit}}},
  year         = {{2006}},
}

@inproceedings{4134,
  author       = {{Kutz, Gerd}},
  keywords     = {{Scientific lecture}},
  location     = {{Zürich (Schweiz)}},
  title        = {{{Modern formulation concepts with actual raw materials}}},
  year         = {{2006}},
}

@article{2734,
  abstract     = {{A new chronic treatment for inherited disorders of long-chain fatty acid oxidation involves administering up to one-third of dietary calories as triheptanoin, a medium-odd-chain triglyceride (Roe CR, Sweetman L, Roe DS, David F, and Brunengraber H. J Clin Invest 110: 259–269, 2002). Heptanoate and C5-ketone bodies derived from its partial oxidation in liver are precursors of anaplerotic propionyl-CoA in peripheral tissues. It was hypothesized that increasing anaplerosis in peripheral tissues would boost energy production. In the present study, we tested the potential of a triheptanoin emulsion as an intravenous nutrient. Normal rats were infused with triheptanoin intravenously or intraduodenally at up to 40% of caloric requirement. The blood concentration ratio (heptanoate/C5-ketone bodies) was high with intravenous and low with intraduodenal triheptanoin infusion. During intravenous infusion of triheptanoin, lipolysis was stimulated but appeared compensated by fatty acid reesterification. During intraduodenal infusion of triheptanoin, lipolysis was not stimulated. Our data support the hypothesis that intravenous triheptanoin could be used to treat decompensated patients with long-chain fatty acid oxidation disorders.}},
  author       = {{Kinman, Renèe P. and Kasumov, Takhar and Jobbins, Kathryn A. and Thomas, Katherine R. and Adams, Jillian E. and Brunengraber, Lisa N. and Kutz, Gerd and Brewer, Wolf-Ulrich  and Roe, Charles R. and Brunengraber, Henri }},
  journal      = {{American journal of physiology, Endocrinology and metabolism}},
  number       = {{4}},
  pages        = {{E860 -- E868}},
  publisher    = {{APS}},
  title        = {{{Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats}}},
  doi          = {{https://doi.org/10.1152/ajpendo.00366.2005}},
  volume       = {{291}},
  year         = {{2006}},
}

@misc{12068,
  author       = {{Bruns, Christina and Kutz, Gerd and Wilms, J.}},
  location     = {{Nürnberg}},
  title        = {{{A new manufacturing process for ISDN retard pellets: feasibility studies and risk assessment}}},
  year         = {{2005}},
}

@misc{12069,
  author       = {{Kardel, M. and Kutz, Gerd and Rosito, R.  and von Zydowitz, H. }},
  location     = {{Nürnberg}},
  title        = {{{Quality and economic efficiency of inspection methods}}},
  year         = {{2005}},
}

@inproceedings{4221,
  author       = {{Kutz, Gerd and Salzmann, Volker and Bruns, Christina and Henning, S.}},
  keywords     = {{Scientific lecture}},
  location     = {{Nürnberg}},
  title        = {{{Feasibility studies on emulsion manufacturing using the Co-Twister processing facility}}},
  year         = {{2005}},
}

@inproceedings{4223,
  author       = {{Generotzky, F. and Hennig, S.  and Kutz, Gerd}},
  keywords     = {{Scientific poster}},
  location     = {{Nürnberg}},
  title        = {{{Heat distribution and determination of cold spots within a stopper treatment and transfer unit}}},
  year         = {{2005}},
}

@inproceedings{4224,
  author       = {{Nierychlok, N. and Kutz, Gerd}},
  keywords     = {{Scientific poster}},
  location     = {{Nürnberg}},
  title        = {{{Implementation of a computerised system for the monitoring of storage conditions within the scope of stability testing}}},
  year         = {{2005}},
}

@inproceedings{4226,
  author       = {{Brenner, S. and Hellweg, E. and Kutz, Gerd}},
  keywords     = {{Scientific poster}},
  location     = {{Nürnberg}},
  title        = {{{Comparative validation studies on microbial collecctors to be used in isolator systems }}},
  year         = {{2005}},
}

@inproceedings{4227,
  author       = {{Generotzky, F. and Kutz, Gerd and Luenz, N.}},
  keywords     = {{Scientific poster}},
  location     = {{Nürnberg}},
  title        = {{{Investigations on the CIP-System of the Lyophilisator GT 6750}}},
  year         = {{2005}},
}

@inproceedings{4228,
  author       = {{Kutz, Gerd}},
  keywords     = {{Vortrag}},
  location     = {{Neuenburg                                                     }},
  title        = {{{Verfahren zur Bestimmung von Partikel- bzw. Tröpfchengrößen in Emulsionssystemen}}},
  year         = {{2005}},
}

@inproceedings{4230,
  author       = {{Kutz, Gerd}},
  keywords     = {{Vortrag}},
  location     = {{Detmold}},
  title        = {{{Neue Rohstoffe für die Formulierung von Emulsionen }}},
  year         = {{2005}},
}

@inproceedings{4474,
  author       = {{Kutz, Gerd}},
  location     = {{Fachhochschule Lippe und Höxter in Detmold}},
  title        = {{{Innovationskonzhepte in Hautpflegemitteln: Entwicklungstrends, Formulierungsstrategien, Charaktersisierung}}},
  year         = {{2005}},
}

@inproceedings{2680,
  author       = {{Kutz, Gerd}},
  location     = {{Neuenburg}},
  title        = {{{Verfahren zur Bestimmung von Partikel- bzw. Tröpfchengrößen in Emulsionssystemen}}},
  year         = {{2005}},
}

@article{2718,
  author       = {{Kutz, Gerd and Henning, Sabine and Bruns, Christiane}},
  journal      = {{PZ Prisma - Pharmazeutische Zeitung}},
  number       = {{4}},
  pages        = {{219--227}},
  title        = {{{Neue Hilfsstoffe für Dermatika- Vom galenischen Rohstoff zum wertsteigernden Additiv}}},
  volume       = {{12}},
  year         = {{2005}},
}

@inproceedings{4233,
  author       = {{Kutz, Gerd}},
  keywords     = {{Vortrag}},
  location     = {{Lemgo}},
  title        = {{{Qualifizierung und Validierung in der pharmazeutisch-betrieblichen Praxis}}},
  year         = {{2004}},
}

@article{4235,
  author       = {{Kutz, Gerd and Henning, S. and Rac, D. and Scheppler, P.}},
  issn         = {{0942-7694}},
  journal      = {{SÖFW-Journal : internationales Journal für angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte }},
  number       = {{1/2}},
  pages        = {{35--44}},
  publisher    = {{Verl. für Chemische Industrie }},
  title        = {{{PEG/PPG-25/25 Dimethicone: Was leistet es? : Vom Dreikomonentendiagramm zu sensorisch überzeugenden und kosmetisch wirksamen Formulierungen}}},
  volume       = {{130}},
  year         = {{2004}},
}

@article{2739,
  author       = {{Kutz, Gerd and Nürnberg, E.}},
  issn         = {{0031-711X }},
  journal      = {{Pharmazeutische Industrie}},
  publisher    = {{Editio-Cantor-Verl. für Medizin und Naturwiss. }},
  title        = {{{Kollagen-Hydrolysate als pharmazeutische Hilfsstoffe. 2. Mitteilung}}},
  year         = {{2004}},
}

@article{2746,
  author       = {{Kutz, Gerd and Hennigs, Sören}},
  issn         = {{0016-3538}},
  journal      = {{GIT : Labor-Fachzeitschrift}},
  number       = {{9}},
  pages        = {{894 -- 896}},
  publisher    = {{Wiley-VCH Verlag }},
  title        = {{{Partikelgrößen in Pharmazie und Kosmetik}}},
  volume       = {{47}},
  year         = {{2004}},
}

@misc{11505,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Produktbeschreibende physikalisch-chemische Verfahren inkl. „in situ“ und „online“ Partikelgrößenbestimmung mittels Lasertechnologie}}},
  year         = {{2003}},
}

@misc{11506,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Hautpflegemittel: Formulierungsstrategien, Entwicklungstrends, Charakterisierung}}},
  year         = {{2003}},
}

@misc{11507,
  author       = {{Kutz, Gerd}},
  location     = {{Krefeld}},
  title        = {{{Herstellung von Hautpflegemitteln}}},
  year         = {{2002}},
}

@misc{11508,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Herstellung und Qualitatssicherung von Hautpflegemitteln }}},
  year         = {{2001}},
}

@book{4279,
  author       = {{Kutz, Gerd and Frieß, Stefan and Henning, sabine and Lünz, Nicole}},
  isbn         = {{978-3-87846-224-8 }},
  publisher    = {{Verlag für chemische Industrie H. Ziolkowsky Gmbh}},
  title        = {{{Kosmetische Emulsionen und Cremes - Formulierung, Herstellung, Prüfung }}},
  year         = {{2001}},
}

@book{4280,
  author       = {{Kutz, Gerd}},
  isbn         = {{5-901 100-19-0}},
  publisher    = {{Clavel Publishing Company Cosmetics & Medicine}},
  title        = {{{Kosmetische Emulsionen und Cremes - Formulierung, Herstellung, Prüfung - Russische Übersetzung}}},
  year         = {{2001}},
}

@inproceedings{4477,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Moderne Hautpflegemittel: Entwicklung, Herstellung und Prüfung}}},
  year         = {{2001}},
}

@misc{11509,
  author       = {{Kutz, Gerd}},
  location     = {{Detmold}},
  title        = {{{Moderne Hautpflegemittel: Entwicklung, Herstellung und Prüfung}}},
  year         = {{2000}},
}

@article{4343,
  author       = {{Kutz, Gerd and Peltner, D. }},
  issn         = {{1430-4031 }},
  journal      = {{Kosmetische Medizin }},
  pages        = {{44}},
  publisher    = {{gmc - Gesundheitsmedien und Congress GmbH}},
  title        = {{{Aktuelle Formulierungskonzepte moderner Hautkosmetika am Beispiel der trockenen Haut}}},
  volume       = {{20}},
  year         = {{1999}},
}

@article{4344,
  author       = {{Kutz, Gerd and Peltner, D.}},
  issn         = {{0031-7136}},
  journal      = {{Pharmazeutische Zeitung : PZ ; die Zeitschrift der deutschen Apotheker ; Zentralorgan für die Apotheker der Bundesrepublik Deutschland }},
  number       = {{24}},
  pages        = {{35--41}},
  title        = {{{Neuere Emulgatoren im Einsatz}}},
  volume       = {{144}},
  year         = {{1999}},
}

@inproceedings{4345,
  author       = {{Kutz, Gerd}},
  location     = {{Berlin }},
  title        = {{{Aktuelle Formulierungskonzepte für hautpflegende Externa}}},
  year         = {{1999}},
}

@article{4510,
  author       = {{Kutz, Gerd and Frieß, Stefan}},
  isbn         = {{3-87846-203-4}},
  journal      = {{Kosmetikjahrbuch }},
  title        = {{{Moderne Verfahren zur Herstellung halbfester und flüssiger Emulsionen - Eine aktuelle Übersicht}}},
  year         = {{1999}},
}

@inproceedings{4346,
  author       = {{Kutz, Gerd}},
  location     = {{München}},
  title        = {{{Neue Emulgatoren in der Kosemtik}}},
  year         = {{1998}},
}

@article{4347,
  author       = {{Kutz, Gerd and Frieß, S.}},
  issn         = {{0942-7694}},
  journal      = {{SÖFW-Journal }},
  number       = {{5}},
  pages        = {{308--313}},
  publisher    = {{Verl. für Chemische Industrie, Ziolkowsky }},
  title        = {{{Moderne Verfahren zur Herstellung halbfester und flülssiger Emulsionen - Eine aktuelle Übersicht}}},
  volume       = {{124}},
  year         = {{1998}},
}

@article{4348,
  author       = {{Pollet, D. and Strodtholz, I. and Müller, R. P. A. and Kutz, Gerd and Hoppe, U.}},
  issn         = {{1873-569X}},
  journal      = {{Journal of dermatological science : the official journal of the Japanese Society for Investigative Dermatology. Supplement }},
  number       = {{supp. 1}},
  pages        = {{218}},
  publisher    = {{Elsevier Science}},
  title        = {{{Chromosomal damage in keratinocytes as an indicator for the genotoxic action of UV radiation}}},
  doi          = {{10.1016/S0923-1811(98)84305-3}},
  volume       = {{16}},
  year         = {{1998}},
}

@inproceedings{4349,
  author       = {{Kutz, Gerd}},
  location     = {{Bad Oeynhausen}},
  title        = {{{Herstellung von Hautpflegemitteln}}},
  year         = {{1998}},
}

@article{4508,
  author       = {{Kutz, Gerd and Frieß, Stefan}},
  isbn         = {{3-87846-196-8}},
  journal      = {{Emulsions}},
  publisher    = {{Verlag für chemische Industrie}},
  title        = {{{Moderne Verfahren zur Herstellung halbfester und flüssiger Emulsionen - Eine aktuelle Übersicht}}},
  year         = {{1998}},
}

@misc{11502,
  author       = {{Kutz, Gerd}},
  location     = {{Düsseldorf}},
  title        = {{{Galenische Charaktersisierung ausgewählte Hautpflegeprodukte}}},
  year         = {{1997}},
}

@article{4350,
  author       = {{Peltner, D. and Kutz, Gerd}},
  issn         = {{0944-8942 }},
  journal      = {{Euro Cosmetics : the magazine for cosmetic industry leaders }},
  number       = {{10}},
  pages        = {{S. 24--32}},
  publisher    = {{Inter-Euro-Medien }},
  title        = {{{Influence of dimethyl-ß-cyclodextrin on solubility, photostability and photoprotection of octyl methoxycinnamate and 4- methylbenzylidene camphor}}},
  volume       = {{5}},
  year         = {{1997}},
}

@article{4351,
  author       = {{Kutz, Gerd}},
  issn         = {{0031-7136}},
  journal      = {{Pharmazeutische Zeitung : PZ ; die Zeitschrift der deutschen Apotheker ; Zentralorgan für die Apotheker der Bundesrepublik Deutschland}},
  number       = {{45}},
  pages        = {{11--15}},
  publisher    = {{Avoxa, Mediengruppe Deutscher Apotheker }},
  title        = {{{Galenische Charaktersisierung ausgewählte Hautpflegeprodukte }}},
  volume       = {{142}},
  year         = {{1997}},
}

@article{4353,
  author       = {{Kutz, Gerd and von Höveling, H. and Klotz, A.}},
  issn         = {{0031-1952}},
  journal      = {{Parfümerie und Kosmetik : Parfüme u. Kosmetika, Kosmetologie, kosmetische Chemie ; internat. Zeitschr. für wissenschaftl. u. techn. Grundlagen d. Parfüm- und Kosmetika-Industrie }},
  number       = {{11}},
  pages        = {{700--703}},
  publisher    = {{Hüthig }},
  title        = {{{Use of Image Analysis to Determine the Hemolytic Activity of Sufactants}}},
  volume       = {{77}},
  year         = {{1997}},
}

@article{2707,
  author       = {{Kutz, Gerd and Biehl, P. and Waldmann-Laue, M. and Jackwerth, B.}},
  journal      = {{SÖFW-Journal : internationales Journal für angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte}},
  number       = {{3}},
  pages        = {{145--150}},
  publisher    = {{Verl. für Chemische Industrie, Ziolkowsky}},
  title        = {{{Zur Auswahl von O/W-Emulgatoren fur den Einsatz in Hautpflegeprodukten bei sensibler Haut : Teilergebnisse aus »Charakterisierung hautfreundlicher O/W-Emulgatoren«, P. Biehl, Diplomarbeit Lemgo 1995}}},
  volume       = {{123}},
  year         = {{1997}},
}

@misc{11504,
  author       = {{Kutz, Gerd}},
  location     = {{Lemgo}},
  title        = {{{Neue Entwicklungen an der Fachhochschule Lippe}}},
  year         = {{1996}},
}

@article{4357,
  author       = {{Kutz, Gerd}},
  issn         = {{0340-8078 }},
  journal      = {{Der Deutsche Dermatologe}},
  number       = {{5}},
  pages        = {{486--494}},
  publisher    = {{Medi-A-Derm}},
  title        = {{{Die Qualität kosmetischer Mittel und Europäisches Recht}}},
  volume       = {{44}},
  year         = {{1996}},
}

@article{4451,
  author       = {{Kutz, Gerd and ten Haaf, A.}},
  issn         = {{0942-7694 }},
  journal      = {{SÖFW-Journal : internationales Journal für angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte}},
  number       = {{Nr. 4}},
  pages        = {{216--231}},
  publisher    = {{Verl. für Chemische Industrie }},
  title        = {{{Einsatz der Dynamischen Differenz kalorimetrie (DDK) zur Stabilitätsbeurteilung halbfester, disperser Systeme}}},
  volume       = {{122}},
  year         = {{1996}},
}

@inproceedings{4358,
  author       = {{Kutz, Gerd}},
  location     = {{Lemgo}},
  title        = {{{Von der Herstellung über die Prüfung zur Deklaration - bringt Europa mehr Sicherheit? }}},
  year         = {{1995}},
}

@misc{4360,
  author       = {{Kutz, Gerd and Heckmüller, H.}},
  title        = {{{Pharmaceutical Composition Containing Lipophilic Drugs (Nanoemulsion)}}},
  year         = {{1994}},
}

@inproceedings{4361,
  author       = {{Kutz, Gerd}},
  location     = {{Lemgo}},
  title        = {{{Zur Beurteilung toxikologischer Daten}}},
  year         = {{1993}},
}

@misc{4362,
  author       = {{Kutz, Gerd and Frieß, S.}},
  booktitle    = {{Deutsche Apotheker-Zeitung : DAZ ; unabhängige pharmazeutische Zeitschrift für Wissenschaft und Praxis }},
  issn         = {{0011-9857 }},
  number       = {{14}},
  pages        = {{S. 1242--1245}},
  publisher    = {{Dt. Apotheker-Verl. }},
  title        = {{{Pulverinhalatoren - vom feindispersen System zum fertigen Arzneimittel }}},
  volume       = {{133}},
  year         = {{1993}},
}

@misc{4576,
  author       = {{Kutz, Gerd and Heckmüller, H.}},
  publisher    = {{ Technische Hochschule Ostwestfalen-Lippe}},
  title        = {{{Pharmazeutische Formulierung und Verfahren zu deren Herstellung (Brausetabletten)}}},
  year         = {{1993}},
}

@misc{4577,
  author       = {{Kutz, Gerd}},
  publisher    = {{ Technische Hochschule Ostwestfalen-Lippe}},
  title        = {{{Pharmazeutische Formulierung und Verfahren zu deren Herstellung (Pellets)}}},
  year         = {{1993}},
}

@inproceedings{4363,
  author       = {{Kutz, Gerd}},
  location     = {{Vama}},
  title        = {{{Collagenhydrolysates as polymeric surfactants }}},
  year         = {{1992}},
}

@article{4364,
  author       = {{Kutz, Gerd and Nürnberg, E.}},
  issn         = {{0939-6411 }},
  journal      = {{Eur. J. Pharm. Biopharm.}},
  number       = {{1}},
  pages        = {{S. 26--31}},
  publisher    = {{Elsevier}},
  title        = {{{Untersuchungen zur Polymorphie eines neuen nichtsteroidalen Antirheumatikums}}},
  volume       = {{38}},
  year         = {{1992}},
}

@inproceedings{4365,
  author       = {{Nürnberg, E. and Kutz, Gerd}},
  location     = {{Bratislava (Slowakei)}},
  title        = {{{Optimierung biopharmazeutisch relevanter Eigenschaften eines schwerlöslichen nichtsteroidalen Antirheumatikums}}},
  year         = {{1990}},
}

@article{4366,
  author       = {{Kutz, Gerd and Nürnberg, E.}},
  issn         = {{0340-3157 }},
  journal      = {{Acta pharmaceutica technologica : international journal of drug formulation and biopharmaceutica}},
  number       = {{1}},
  pages        = {{S. 27}},
  publisher    = {{Wiss. Verl.-Ges. }},
  title        = {{{Untersuchungen zur Polymorphie des NSAID Diclofenac-5-Aminosalicylsäure }}},
  volume       = {{36}},
  year         = {{1990}},
}

@article{4397,
  author       = {{Nürnberg, E. and Kutz, Gerd}},
  issn         = {{1616-7074 }},
  journal      = {{Die pharmazeutische Industrie : pharmind ; Veröffentlichungen über sämtliche Aspekte der Herstellung und des Vertriebes pharmazeutischer Erzeugnisse ; Forum der Pharma-Industrie für alle Themen der Pharma-, Gesundheits- und Sozialpolitik sowie des Arzneimittelwesens im Umfeld der Marktbeteiligten ; Mitteilungsorgan der Verbände der deutschen Pharma-Industrie }},
  number       = {{9}},
  pages        = {{1037--1040}},
  publisher    = {{ECV, Editio-Cantor-Verl. }},
  title        = {{{Kollagenhydrolysate als pharmazeutische Hilfsstoffe}}},
  volume       = {{51}},
  year         = {{1989}},
}

@article{4453,
  author       = {{Nürnberg, E. and Kutz, Gerd}},
  issn         = {{0031-7136}},
  journal      = {{Pharmazeutische Zeitung : PZ ; die Zeitschrift der deutschen Apotheker ; Zentralorgan für die Apotheker der Bundesrepublik Deutschland }},
  number       = {{2}},
  pages        = {{27--32}},
  title        = {{{Kollagenhydrolysate als pharmazeutische Hilfsstoffe 1. Mitteilung: Kennzeichnung von Kollagenhydrolysaten durch thermische Untersuchungsmethoden}}},
  volume       = {{134}},
  year         = {{1989}},
}

@misc{4456,
  author       = {{Kutz, Gerd and Nürnberg, E.}},
  booktitle    = {{Archiv der Pharmazie}},
  issn         = {{0342-9385}},
  pages        = {{ 685}},
  publisher    = {{Wiley-VCH Verlag}},
  title        = {{{Technologisch relevante Aspekte bei der Formulierung von Diclofenac-5-amino-salicylsäure unter Einsatz von Kollagenhydrolysaten}}},
  volume       = {{322}},
  year         = {{1989}},
}

@misc{4457,
  author       = {{Kutz, Gerd and Nürnberg, E.}},
  booktitle    = {{Archiv der Pharmazie}},
  issn         = {{0342-9385}},
  pages        = {{S. 689}},
  publisher    = {{Wiley-VCH Verlag}},
  title        = {{{Kollagenhydrolysate als Trägerstoffe für solid solutions}}},
  volume       = {{321}},
  year         = {{1988}},
}