[{"intvolume":"         9","user_id":"83781","type":"scientific_journal_article","doi":"10.1016/j.ijpx.2025.100331","article_number":"100331","_id":"12781","place":"Amsterdam","publication_status":"published","quality_controlled":"1","publisher":"Elsevier BV","abstract":[{"text":"Roller compaction/dry granulation (RC/DG) is a key process in pharmaceutical manufacturing for improving powder flowability, density, and segregation resistance. Advanced statistical modeling was used to optimize RC/DG process parameters and subsequently binder compositions by employing process and mixture design experiments. The authors used microcrystalline cellulose (MCC), silicified MCC (SMCC), and dicalcium phosphate (DCP) as filler-binder examples in RC/DG experiments. Granule and tablet properties, including flowability, bulk and tapped densities, as well as resistance to crushing, were analyzed using compendial methods. The process design experiments confirmed that RC/DG reduces manufacturability compared to direct compression. Optimal processing conditions, balancing sufficient tablet strengths and granule formation, were identified to be between 20 (SCF * ϑ) [kN/cm] and ∼ 60 (SCF * ϑ) [kN/cm]. Thereby (ϑ) is defined as the screw-to-roll speed ratio and (SFC) as the specific compaction force. Mixture design experiments revealed optimal mixtures balancing SMCC, MCC, and DCP to achieve desired properties like low angle of repose, high bulk density, and strong tablets. These findings provide guidance for selecting formulations and process parameters in RC/DG applications. The derived ‘SCF * ϑ’- factor was found to effectively describe the granulation intensity. A superimposed mixture design model based on precise target values of the parameters bulk density, flow properties, and breaking force allowed identification of the best formulation.","lang":"eng"}],"department":[{"_id":"DEP4022"},{"_id":"DEP4028"}],"date_updated":"2025-05-08T08:20:23Z","date_created":"2025-04-11T08:39:07Z","publication_identifier":{"issn":["1873-3476"],"eissn":["2590-1567"]},"publication":"International Journal of Pharmaceutics: X","language":[{"iso":"eng"}],"keyword":["Design of experiments","Roller compaction/dry granulation","RC/DG","Dicalcium phosphate","Microcrystalline cellulose","Silicified microcrystalline cellulose"],"oa":"1","citation":{"ieee":"N. Märkle, G. Warnke, and M. Pein-Hackelbusch, “An iterative process and mixture design approach for dry granulated ternary blends of filler-binders,” <i>International Journal of Pharmaceutics: X</i>, vol. 9, Art. no. 100331, 2025, doi: <a href=\"https://doi.org/10.1016/j.ijpx.2025.100331\">10.1016/j.ijpx.2025.100331</a>.","ama":"Märkle N, Warnke G, Pein-Hackelbusch M. An iterative process and mixture design approach for dry granulated ternary blends of filler-binders. <i>International Journal of Pharmaceutics: X</i>. 2025;9. doi:<a href=\"https://doi.org/10.1016/j.ijpx.2025.100331\">10.1016/j.ijpx.2025.100331</a>","short":"N. Märkle, G. Warnke, M. Pein-Hackelbusch, International Journal of Pharmaceutics: X 9 (2025).","din1505-2-1":"<span style=\"font-variant:small-caps;\">Märkle, Niclas</span> ; <span style=\"font-variant:small-caps;\">Warnke, Gernot</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span>: An iterative process and mixture design approach for dry granulated ternary blends of filler-binders. In: <i>International Journal of Pharmaceutics: X</i> Bd. 9. Amsterdam, Elsevier BV (2025)","chicago-de":"Märkle, Niclas, Gernot Warnke und Miriam Pein-Hackelbusch. 2025. An iterative process and mixture design approach for dry granulated ternary blends of filler-binders. <i>International Journal of Pharmaceutics: X</i> 9. doi:<a href=\"https://doi.org/10.1016/j.ijpx.2025.100331\">10.1016/j.ijpx.2025.100331</a>, .","apa":"Märkle, N., Warnke, G., &#38; Pein-Hackelbusch, M. (2025). An iterative process and mixture design approach for dry granulated ternary blends of filler-binders. <i>International Journal of Pharmaceutics: X</i>, <i>9</i>, Article 100331. <a href=\"https://doi.org/10.1016/j.ijpx.2025.100331\">https://doi.org/10.1016/j.ijpx.2025.100331</a>","chicago":"Märkle, Niclas, Gernot Warnke, and Miriam Pein-Hackelbusch. “An Iterative Process and Mixture Design Approach for Dry Granulated Ternary Blends of Filler-Binders.” <i>International Journal of Pharmaceutics: X</i> 9 (2025). <a href=\"https://doi.org/10.1016/j.ijpx.2025.100331\">https://doi.org/10.1016/j.ijpx.2025.100331</a>.","van":"Märkle N, Warnke G, Pein-Hackelbusch M. An iterative process and mixture design approach for dry granulated ternary blends of filler-binders. International Journal of Pharmaceutics: X. 2025;9.","ufg":"<b>Märkle, Niclas/Warnke, Gernot/Pein-Hackelbusch, Miriam</b>: An iterative process and mixture design approach for dry granulated ternary blends of filler-binders, in: <i>International Journal of Pharmaceutics: X</i> 9 (2025).","bjps":"<b>Märkle N, Warnke G and Pein-Hackelbusch M</b> (2025) An Iterative Process and Mixture Design Approach for Dry Granulated Ternary Blends of Filler-Binders. <i>International Journal of Pharmaceutics: X</i> <b>9</b>.","mla":"Märkle, Niclas, et al. “An Iterative Process and Mixture Design Approach for Dry Granulated Ternary Blends of Filler-Binders.” <i>International Journal of Pharmaceutics: X</i>, vol. 9, 100331, 2025, <a href=\"https://doi.org/10.1016/j.ijpx.2025.100331\">https://doi.org/10.1016/j.ijpx.2025.100331</a>.","havard":"N. Märkle, G. Warnke, M. Pein-Hackelbusch, An iterative process and mixture design approach for dry granulated ternary blends of filler-binders, International Journal of Pharmaceutics: X. 9 (2025)."},"volume":9,"title":"An iterative process and mixture design approach for dry granulated ternary blends of filler-binders","pmid":"1","status":"public","external_id":{"pmid":["40242454 "]},"year":"2025","main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/S2590156725000167"}],"author":[{"first_name":"Niclas","id":"74898","full_name":"Märkle, Niclas","last_name":"Märkle"},{"first_name":"Gernot","full_name":"Warnke, Gernot","last_name":"Warnke"},{"orcid":"0000-0002-7920-0595","full_name":"Pein-Hackelbusch, Miriam","first_name":"Miriam","id":"64952","last_name":"Pein-Hackelbusch"}]},{"external_id":{"isi":["001119084200001"],"pmid":["37631367"]},"main_file_link":[{"open_access":"1","url":"https://www.mdpi.com/1999-4923/15/8/2153"}],"year":"2023","author":[{"last_name":"Fulek","full_name":"Fulek, Ruwen","first_name":"Ruwen","id":"79527"},{"orcid":"https://orcid.org/0000-0002-0502-8032","first_name":"Selina","last_name":"Ramm","full_name":"Ramm, Selina","id":"68713"},{"first_name":"Christian","last_name":"Kiera","full_name":"Kiera, Christian"},{"orcid":"0000-0002-7920-0595","id":"64952","full_name":"Pein-Hackelbusch, Miriam","first_name":"Miriam","last_name":"Pein-Hackelbusch"},{"last_name":"Odefey","id":"74218","full_name":"Odefey, Ulrich","first_name":"Ulrich"}],"pmid":"1","status":"public","title":"A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions","volume":15,"citation":{"van":"Fulek R, Ramm S, Kiera C, Pein-Hackelbusch M, Odefey U. A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. Pharmaceutics. 2023;15(8).","havard":"R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, U. Odefey, A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions, Pharmaceutics. 15 (2023).","bjps":"<b>Fulek R <i>et al.</i></b> (2023) A Machine Learning Approach to Qualitatively Evaluate Different Granulation Phases by Acoustic Emissions. <i>Pharmaceutics</i> <b>15</b>.","mla":"Fulek, Ruwen, et al. “A Machine Learning Approach to Qualitatively Evaluate Different Granulation Phases by Acoustic Emissions.” <i>Pharmaceutics</i>, vol. 15, no. 8, 2153, 2023, <a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>.","ufg":"<b>Fulek, Ruwen u. a.</b>: A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions, in: <i>Pharmaceutics</i> 15 (2023), H. 8.","apa":"Fulek, R., Ramm, S., Kiera, C., Pein-Hackelbusch, M., &#38; Odefey, U. (2023). A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. <i>Pharmaceutics</i>, <i>15</i>(8), Article 2153. <a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>","chicago":"Fulek, Ruwen, Selina Ramm, Christian Kiera, Miriam Pein-Hackelbusch, and Ulrich Odefey. “A Machine Learning Approach to Qualitatively Evaluate Different Granulation Phases by Acoustic Emissions.” <i>Pharmaceutics</i> 15, no. 8 (2023). <a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>.","short":"R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, U. Odefey, Pharmaceutics 15 (2023).","din1505-2-1":"<span style=\"font-variant:small-caps;\">Fulek, Ruwen</span> ; <span style=\"font-variant:small-caps;\">Ramm, Selina</span> ; <span style=\"font-variant:small-caps;\">Kiera, Christian</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span> ; <span style=\"font-variant:small-caps;\">Odefey, Ulrich</span>: A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. In: <i>Pharmaceutics</i> Bd. 15. Basel, MDPI (2023), Nr. 8","chicago-de":"Fulek, Ruwen, Selina Ramm, Christian Kiera, Miriam Pein-Hackelbusch und Ulrich Odefey. 2023. A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. <i>Pharmaceutics</i> 15, Nr. 8. doi:<a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>, .","ama":"Fulek R, Ramm S, Kiera C, Pein-Hackelbusch M, Odefey U. A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. <i>Pharmaceutics</i>. 2023;15(8). doi:<a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>","ieee":"R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, and U. Odefey, “A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions,” <i>Pharmaceutics</i>, vol. 15, no. 8, Art. no. 2153, 2023, doi: <a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>."},"oa":"1","language":[{"iso":"eng"}],"keyword":["wet granulation","acoustic classification","machine learning","convolutional neural networks"],"date_created":"2023-08-15T10:48:15Z","publication_identifier":{"eissn":["1999-4923 "]},"publication":"Pharmaceutics","date_updated":"2025-07-29T13:21:40Z","issue":"8","abstract":[{"lang":"eng","text":"Wet granulation is a frequent process in the pharmaceutical industry. As a starting point for numerous dosage forms, the quality of the granulation not only affects subsequent production steps but also impacts the quality of the final product. It is thus crucial and economical to monitor this operation thoroughly. Here, we report on identifying different phases of a granulation process using a machine learning approach. The phases reflect the water content which, in turn, influences the processability and quality of the granule mass. We used two kinds of microphones and an acceleration sensor to capture acoustic emissions and vibrations. We trained convolutional neural networks (CNNs) to classify the different phases using transformed sound recordings as the input. We achieved a classification accuracy of up to 90% using vibrational data and an accuracy of up to 97% using the audible microphone data. Our results indicate the suitability of using audible sound and machine learning to monitor pharmaceutical processes. Moreover, since recording acoustic emissions is contactless, it readily complies with legal regulations and presents Good Manufacturing Practices."}],"department":[{"_id":"DEP4022"},{"_id":"DEP4028"},{"_id":"DEP4014"}],"quality_controlled":"1","publisher":"MDPI","isi":"1","publication_status":"published","doi":"https://doi.org/10.3390/pharmaceutics15082153","article_number":"2153","_id":"10216","place":"Basel","type":"scientific_journal_article","intvolume":"        15","user_id":"83781"},{"corporate_editor":["Institute of Electrical and Electronics Engineers "],"editor":[{"last_name":"Jasperneite","id":"1899","full_name":"Jasperneite, Jürgen","first_name":"Jürgen"},{"last_name":"Wisniewski","first_name":"Lukasz","full_name":"Wisniewski, Lukasz","id":"1710"},{"last_name":"Fung Man","first_name":"Kim","full_name":"Fung Man, Kim"}],"date_updated":"2025-04-29T07:38:03Z","publication_identifier":{"isbn":["978-1-6654-9314-7"],"eisbn":["978-1-6654-9313-0"],"issn":["1935-4576"]},"publication":"2023 IEEE 21st International Conference on Industrial Informatics (INDIN)","date_created":"2023-11-21T08:17:12Z","keyword":["Spectroscopy","Smoothing methods","Systematics","Phase measurement","Linear regression","Data models","Dielectric measurement"],"language":[{"iso":"eng"}],"oa":"1","citation":{"ama":"Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. (Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , eds.). IEEE; 2023:1-6. doi:<a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">10.1109/INDIN51400.2023.10218012</a>","ieee":"S. Ramm, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. [Piscataway, NJ]: IEEE, 2023, pp. 1–6. doi: <a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">10.1109/INDIN51400.2023.10218012</a>.","chicago-de":"Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. 2023. <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. Hg. von Jürgen Jasperneite, Lukasz Wisniewski, Kim Fung Man, und Institute of Electrical and Electronics Engineers . <i>2023 IEEE 21st International Conference on Industrial Informatics (INDIN)</i>. [Piscataway, NJ]: IEEE. doi:<a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">10.1109/INDIN51400.2023.10218012</a>, .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Ramm, Selina</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span> ; <span style=\"font-variant:small-caps;\">Jasperneite, J.</span> ; <span style=\"font-variant:small-caps;\">Wisniewski, L.</span> ; <span style=\"font-variant:small-caps;\">Fung Man, K.</span> ; <span style=\"font-variant:small-caps;\">Institute of Electrical and Electronics Engineers </span> (Hrsg.): <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. [Piscataway, NJ] : IEEE, 2023","short":"S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.","havard":"S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.","mla":"Ramm, Selina, et al. “Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities.” <i>2023 IEEE 21st International Conference on Industrial Informatics (INDIN)</i>, edited by Jürgen Jasperneite et al., IEEE, 2023, pp. 1–6, <a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">https://doi.org/10.1109/INDIN51400.2023.10218012</a>.","bjps":"<b>Ramm S <i>et al.</i></b> (2023) <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>, Jasperneite J et al. (eds). [Piscataway, NJ]: IEEE.","ufg":"<b>Ramm, Selina u. a.</b>: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, hg. von Jasperneite, Jürgen u. a., [Piscataway, NJ] 2023.","van":"Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , editors. 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE; 2023.","chicago":"Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm, and Miriam Pein-Hackelbusch. <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. Edited by Jürgen Jasperneite, Lukasz Wisniewski, Kim Fung Man, and Institute of Electrical and Electronics Engineers . <i>2023 IEEE 21st International Conference on Industrial Informatics (INDIN)</i>. [Piscataway, NJ]: IEEE, 2023. <a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">https://doi.org/10.1109/INDIN51400.2023.10218012</a>.","apa":"Ramm, S., Hernández Rodriguez, T., Frahm, B., &#38; Pein-Hackelbusch, M. (2023). Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. In J. Jasperneite, L. Wisniewski, K. Fung Man, &#38; Institute of Electrical and Electronics Engineers  (Eds.), <i>2023 IEEE 21st International Conference on Industrial Informatics (INDIN)</i> (pp. 1–6). IEEE. <a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">https://doi.org/10.1109/INDIN51400.2023.10218012</a>"},"title":"Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities","status":"public","page":"1-6","year":"2023","author":[{"orcid":"https://orcid.org/0000-0002-0502-8032","last_name":"Ramm","first_name":"Selina","full_name":"Ramm, Selina","id":"68713"},{"full_name":"Hernández Rodriguez, Tanja","id":"52466","first_name":"Tanja","last_name":"Hernández Rodriguez"},{"first_name":"Björn","id":"45666","full_name":"Frahm, Björn","last_name":"Frahm"},{"orcid":"0000-0002-7920-0595","first_name":"Miriam","id":"64952","full_name":"Pein-Hackelbusch, Miriam","last_name":"Pein-Hackelbusch"}],"main_file_link":[{"url":"https://ieeexplore.ieee.org/document/10218012","open_access":"1"}],"user_id":"83781","type":"conference_editor_article","_id":"10788","doi":"10.1109/INDIN51400.2023.10218012","place":"[Piscataway, NJ]","publication_status":"published","publisher":"IEEE","abstract":[{"text":"For process monitoring, an adequate data preprocessing is crucial to link accessible inline process data with offline measured target variables. Literature, however, does not provide systematic preprocessing strategies. The effects of five different preprocessing strategies on data from a Dielectric Spectroscopy system applied to the Viable Cell Density (VCD) of a mammalian cell cultivation were thus evaluated. Single-frequency measurements are typically used to model the VCD over the growth phase using linear regression or the Cole-Cole model and served as a reference. As multi-frequency measurement is promising to model the VCD beyond the growth phase using Partial Least Squares Regression (PLSR), we further aimed to determine, whether replacing linear regression by PLSR shows comparable modeling performance. All five preprocessing strategies led to comparable results. Exemplary, when using capacitance values at a frequency of 3347 kHz, linear regression resulted in a R2 of 0.90 and a standard deviation of 0.4 % on average. Both normalization techniques had the same positive effect on the results of PLSR. The order of smoothing and normalization was irrelevant for both regression methods. Comparing the results of linear regression and PLSR, the latter obtained on average 9 % better results. Therefore, we concluded that PLSR is preferable over linear regression and is potentially suitable to model the VCD beyond the growth phase, which is suggested to be investigated based on more data sets.","lang":"eng"}],"conference":{"end_date":"2023-07-20","start_date":"2023-07-18","name":"21st International Conference on Industrial Informatics (INDIN)","location":"Lemgo"},"department":[{"_id":"DEP4022"},{"_id":"DEP4028"}]},{"conference":{"start_date":"2023-03-13","end_date":"2023-03-15","name":"Ph.D. Student's Symposium on Tabletting Technology 2023","location":"Rosenberg"},"department":[{"_id":"DEP4022"},{"_id":"DEP4028"},{"_id":"DEP4014"}],"author":[{"orcid":"https://orcid.org/0000-0002-0502-8032","full_name":"Ramm, Selina","id":"68713","first_name":"Selina","last_name":"Ramm"},{"first_name":"Ruwen","last_name":"Fulek","full_name":"Fulek, Ruwen","id":"79527"},{"last_name":"Eberle","first_name":"Veronika Anna","full_name":"Eberle, Veronika Anna"},{"first_name":"Christian","last_name":"Kiera","full_name":"Kiera, Christian"},{"full_name":"Odefey, Ulrich","id":"74218","first_name":"Ulrich","last_name":"Odefey"},{"orcid":"0000-0002-7920-0595","id":"64952","first_name":"Miriam","full_name":"Pein-Hackelbusch, Miriam","last_name":"Pein-Hackelbusch"}],"year":"2023","status":"public","title":"Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation","publication_status":"published","citation":{"short":"S. Ramm, R. Fulek, V.A. Eberle, C. Kiera, U. Odefey, M. Pein-Hackelbusch, Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation, 2023.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Ramm, Selina</span> ; <span style=\"font-variant:small-caps;\">Fulek, Ruwen</span> ; <span style=\"font-variant:small-caps;\">Eberle, Veronika Anna</span> ; <span style=\"font-variant:small-caps;\">Kiera, Christian</span> ; <span style=\"font-variant:small-caps;\">Odefey, Ulrich</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span>: <i>Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation</i>, 2023","chicago-de":"Ramm, Selina, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich Odefey und Miriam Pein-Hackelbusch. 2023. <i>Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation</i>.","ama":"Ramm S, Fulek R, Eberle VA, Kiera C, Odefey U, Pein-Hackelbusch M. <i>Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation</i>.; 2023.","van":"Ramm S, Fulek R, Eberle VA, Kiera C, Odefey U, Pein-Hackelbusch M. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. 2023.","havard":"S. Ramm, R. Fulek, V.A. Eberle, C. Kiera, U. Odefey, M. Pein-Hackelbusch, Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation, 2023.","mla":"Ramm, Selina, et al. <i>Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation</i>. 2023.","bjps":"<b>Ramm S <i>et al.</i></b> (2023) <i>Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation</i>. .","ufg":"<b>Ramm, Selina u. a.</b>: Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation, o. O. 2023.","ieee":"S. Ramm, R. Fulek, V. A. Eberle, C. Kiera, U. Odefey, and M. Pein-Hackelbusch, <i>Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation</i>. 2023.","apa":"Ramm, S., Fulek, R., Eberle, V. A., Kiera, C., Odefey, U., &#38; Pein-Hackelbusch, M. (2023). <i>Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation</i>. Ph.D. Student’s Symposium on Tabletting Technology 2023, Rosenberg.","chicago":"Ramm, Selina, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich Odefey, and Miriam Pein-Hackelbusch. <i>Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation</i>, 2023."},"language":[{"iso":"eng"}],"_id":"9627","date_created":"2023-03-16T09:46:10Z","type":"conference_speech","date_updated":"2025-07-29T13:23:12Z","user_id":"83781"},{"publication_status":"published","abstract":[{"lang":"eng","text":"Glove occlusion might enhance skin sensitivity to a subsequent detergent challenge (occlusion effect). Thus, some skin protection creams (PC) claim to protect against this effect of occlusion, and are recommended to be used before wearing liquid‐proof gloves.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>To evaluate the effect of PC applied prior to glove occlusion on the ‘occlusion effect’—refers to increased susceptibility of the skin to a model detergent.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>One hundred and eleven volunteers were enrolled in a single‐blind, randomized study. Seven PCs were applied before glove occlusion over 7 days (D1–D7). After sodium lauryl sulphate (SLS) challenge, we compared the irritation between the areas treated with PC and occlusion alone. Clinical scoring and bioengineering methods (capacitance, transepidermal water loss [TEWL], and colourimetry [erythema]) were used to quantify the irritant reactions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>After 1 week of occlusion and PC application, we did not observe significant changes in TEWL, nor in erythema, whereas skin hydration raised in three cream‐treated areas. On day 10, after a challenge with SLS, some products significantly aggravated the skin irritation as compared to occlusion alone.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The ‘occlusion effect’—shown as higher skin susceptibility to a model detergent—was not mitigated by PCs when applied prior to glove occlusion. On the contrary, some PCs might have negative effects on skin barrier function and augment such sensitivity."}],"issue":"5","department":[{"_id":"DEP4022"}],"quality_controlled":"1","publisher":"Wiley","type":"scientific_journal_article","intvolume":"        88","user_id":"83781","doi":"10.1111/cod.14287","_id":"12897","place":"Oxford","title":"Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study","citation":{"ieee":"M. Gina, K. Wichert, G. Kutz, T. Brüning, and M. Fartasch, “Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study,” <i>Contact dermatitis : environmental and occupational dermatitis</i>, vol. 88, no. 5, pp. 372–382, 2023, doi: <a href=\"https://doi.org/10.1111/cod.14287\">10.1111/cod.14287</a>.","ama":"Gina M, Wichert K, Kutz G, Brüning T, Fartasch M. Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study. <i>Contact dermatitis : environmental and occupational dermatitis</i>. 2023;88(5):372-382. doi:<a href=\"https://doi.org/10.1111/cod.14287\">10.1111/cod.14287</a>","chicago":"Gina, Michal, Katharina Wichert, Gerd Kutz, Thomas Brüning, and Manigé Fartasch. “Applying Skin Protective Cream and the Wearing of Gloves?—A Randomized Controlled Experimental Study.” <i>Contact Dermatitis : Environmental and Occupational Dermatitis</i> 88, no. 5 (2023): 372–82. <a href=\"https://doi.org/10.1111/cod.14287\">https://doi.org/10.1111/cod.14287</a>.","apa":"Gina, M., Wichert, K., Kutz, G., Brüning, T., &#38; Fartasch, M. (2023). Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study. <i>Contact Dermatitis : Environmental and Occupational Dermatitis</i>, <i>88</i>(5), 372–382. <a href=\"https://doi.org/10.1111/cod.14287\">https://doi.org/10.1111/cod.14287</a>","havard":"M. Gina, K. Wichert, G. Kutz, T. Brüning, M. Fartasch, Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study, Contact Dermatitis : Environmental and Occupational Dermatitis. 88 (2023) 372–382.","mla":"Gina, Michal, et al. “Applying Skin Protective Cream and the Wearing of Gloves?—A Randomized Controlled Experimental Study.” <i>Contact Dermatitis : Environmental and Occupational Dermatitis</i>, vol. 88, no. 5, 2023, pp. 372–82, <a href=\"https://doi.org/10.1111/cod.14287\">https://doi.org/10.1111/cod.14287</a>.","bjps":"<b>Gina M <i>et al.</i></b> (2023) Applying Skin Protective Cream and the Wearing of Gloves?—A Randomized Controlled Experimental Study. <i>Contact dermatitis : environmental and occupational dermatitis</i> <b>88</b>, 372–382.","ufg":"<b>Gina, Michal u. a.</b>: Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study, in: <i>Contact dermatitis : environmental and occupational dermatitis</i> 88 (2023), H. 5,  S. 372–382.","van":"Gina M, Wichert K, Kutz G, Brüning T, Fartasch M. Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study. Contact dermatitis : environmental and occupational dermatitis. 2023;88(5):372–82.","chicago-de":"Gina, Michal, Katharina Wichert, Gerd Kutz, Thomas Brüning und Manigé Fartasch. 2023. Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study. <i>Contact dermatitis : environmental and occupational dermatitis</i> 88, Nr. 5: 372–382. doi:<a href=\"https://doi.org/10.1111/cod.14287\">10.1111/cod.14287</a>, .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Gina, Michal</span> ; <span style=\"font-variant:small-caps;\">Wichert, Katharina</span> ; <span style=\"font-variant:small-caps;\">Kutz, Gerd</span> ; <span style=\"font-variant:small-caps;\">Brüning, Thomas</span> ; <span style=\"font-variant:small-caps;\">Fartasch, Manigé</span>: Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study. In: <i>Contact dermatitis : environmental and occupational dermatitis</i> Bd. 88. Oxford, Wiley (2023), Nr. 5, S. 372–382","short":"M. Gina, K. Wichert, G. Kutz, T. Brüning, M. Fartasch, Contact Dermatitis : Environmental and Occupational Dermatitis 88 (2023) 372–382."},"volume":88,"external_id":{"pmid":["36727715"]},"year":"2023","author":[{"first_name":"Michal","full_name":"Gina, Michal","last_name":"Gina"},{"full_name":"Wichert, Katharina","last_name":"Wichert","first_name":"Katharina"},{"first_name":"Gerd","full_name":"Kutz, Gerd","last_name":"Kutz","id":"12015"},{"full_name":"Brüning, Thomas","first_name":"Thomas","last_name":"Brüning"},{"last_name":"Fartasch","first_name":"Manigé","full_name":"Fartasch, Manigé"}],"page":"372-382","pmid":"1","status":"public","date_created":"2025-05-08T08:23:15Z","publication_identifier":{"eissn":["1600-0536"],"issn":["0105-1873"]},"publication":"Contact dermatitis : environmental and occupational dermatitis","date_updated":"2025-05-08T08:26:34Z","language":[{"iso":"eng"}],"keyword":["barrier disturbance","glove occlusion","irritant contact dermatitis","irritation","non-invasive measuring methods","occupational contact dermatitis","skin barrier disturbance","skin protective cream","wet work."]},{"publication_identifier":{"eissn":["1999-4923"]},"publication":"Pharmaceutics","date_created":"2023-03-03T11:23:01Z","date_updated":"2025-07-29T13:22:53Z","oa":"1","keyword":["wet granulation","liquid requirement","granulation endpoint","compression density"],"language":[{"iso":"eng"}],"title":"Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation.","citation":{"ama":"Ramm S, Fulek R, Eberle VA, Kiera C, Odefey U, Pein-Hackelbusch M. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. <i>Pharmaceutics</i>. 2022;14(11). doi:<a href=\"https://doi.org/10.3390/pharmaceutics14112303\">https://doi.org/10.3390/pharmaceutics14112303</a>","ieee":"S. Ramm, R. Fulek, V. A. Eberle, C. Kiera, U. Odefey, and M. Pein-Hackelbusch, “Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation.,” <i>Pharmaceutics</i>, vol. 14, no. 11, Art. no. 2303, 2022, doi: <a href=\"https://doi.org/10.3390/pharmaceutics14112303\">https://doi.org/10.3390/pharmaceutics14112303</a>.","van":"Ramm S, Fulek R, Eberle VA, Kiera C, Odefey U, Pein-Hackelbusch M. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. Pharmaceutics. 2022;14(11).","ufg":"<b>Ramm, Selina u. a.</b>: Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation., in: <i>Pharmaceutics</i> 14 (2022), H. 11.","mla":"Ramm, Selina, et al. “Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation.” <i>Pharmaceutics</i>, vol. 14, no. 11, 2303, 2022, <a href=\"https://doi.org/10.3390/pharmaceutics14112303\">https://doi.org/10.3390/pharmaceutics14112303</a>.","havard":"S. Ramm, R. Fulek, V.A. Eberle, C. Kiera, U. Odefey, M. Pein-Hackelbusch, Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation., Pharmaceutics. 14 (2022).","bjps":"<b>Ramm S <i>et al.</i></b> (2022) Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. <i>Pharmaceutics</i> <b>14</b>.","apa":"Ramm, S., Fulek, R., Eberle, V. A., Kiera, C., Odefey, U., &#38; Pein-Hackelbusch, M. (2022). Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. <i>Pharmaceutics</i>, <i>14</i>(11), Article 2303. <a href=\"https://doi.org/10.3390/pharmaceutics14112303\">https://doi.org/10.3390/pharmaceutics14112303</a>","chicago":"Ramm, Selina, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich Odefey, and Miriam Pein-Hackelbusch. “Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation.” <i>Pharmaceutics</i> 14, no. 11 (2022). <a href=\"https://doi.org/10.3390/pharmaceutics14112303\">https://doi.org/10.3390/pharmaceutics14112303</a>.","short":"S. Ramm, R. Fulek, V.A. Eberle, C. Kiera, U. Odefey, M. Pein-Hackelbusch, Pharmaceutics 14 (2022).","din1505-2-1":"<span style=\"font-variant:small-caps;\">Ramm, Selina</span> ; <span style=\"font-variant:small-caps;\">Fulek, Ruwen</span> ; <span style=\"font-variant:small-caps;\">Eberle, Veronika Anna</span> ; <span style=\"font-variant:small-caps;\">Kiera, Christian</span> ; <span style=\"font-variant:small-caps;\">Odefey, Ulrich</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span>: Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. In: <i>Pharmaceutics</i> Bd. 14. Basel, MDPI (2022), Nr. 11","chicago-de":"Ramm, Selina, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich Odefey und Miriam Pein-Hackelbusch. 2022. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. <i>Pharmaceutics</i> 14, Nr. 11. doi:<a href=\"https://doi.org/10.3390/pharmaceutics14112303\">https://doi.org/10.3390/pharmaceutics14112303</a>, ."},"volume":14,"external_id":{"isi":["000883998100001"],"pmid":["36365122"]},"year":"2022","author":[{"orcid":"https://orcid.org/0000-0002-0502-8032","full_name":"Ramm, Selina","id":"68713","last_name":"Ramm","first_name":"Selina"},{"id":"79527","first_name":"Ruwen","full_name":"Fulek, Ruwen","last_name":"Fulek"},{"last_name":"Eberle","full_name":"Eberle, Veronika Anna","first_name":"Veronika Anna"},{"last_name":"Kiera","first_name":"Christian","full_name":"Kiera, Christian"},{"last_name":"Odefey","first_name":"Ulrich","id":"74218","full_name":"Odefey, Ulrich"},{"first_name":"Miriam","id":"64952","last_name":"Pein-Hackelbusch","full_name":"Pein-Hackelbusch, Miriam","orcid":"0000-0002-7920-0595"}],"main_file_link":[{"url":"https://www.mdpi.com/1999-4923/14/11/2303","open_access":"1"}],"status":"public","pmid":"1","type":"scientific_journal_article","intvolume":"        14","user_id":"83781","_id":"9568","doi":"https://doi.org/10.3390/pharmaceutics14112303","article_number":"2303","place":"Basel","isi":"1","publication_status":"published","issue":"11","abstract":[{"text":"Pellet production is a multi-step manufacturing process comprising granulation, extrusion and spheronisation. The first step represents a critical control point, since the quality of the granule mass highly influences subsequent process steps and, consequently, the quality of final pellets. The most important parameter of wet granulation is the liquid requirement, which can often only be quantitatively evaluated after further process steps. To identify an alternative for optimal liquid requirements, experiments were conducted with a formulation based on lactose and microcrystalline cellulose. Granules were analyzed with a Powder Vertical Shear Rig. We identified the compression density (ρpress) as the said alternative, linking information from the powder material and the moisture content (R2 = 0.995). We used ρpress to successfully predict liquid requirements for unknown formulation compositions. By means of this prediction, pellets with high quality, regarding shape and size distribution, were produced by carrying out a multi-step manufacturing process. Furthermore, the applicability of ρpress as an alternative quality parameter to other placebo formulations and to formulations containing active pharmaceutical ingredients (APIs) was demonstrated.","lang":"eng"}],"department":[{"_id":"DEP4022"},{"_id":"DEP4028"},{"_id":"DEP4014"}],"publisher":"MDPI"},{"title":"Impact of formulation and process parameters in twin screw hot-melt granulation coupled with in-line particle size analysis of sustained release HPMC granules","publication_status":"published","citation":{"ama":"Kutz G, Repka M, Thipsay P. Impact of formulation and process parameters in twin screw hot-melt granulation coupled with in-line particle size analysis of sustained release HPMC granules. In: ; 2018.","ieee":"G. Kutz, M. Repka, and P. Thipsay, “Impact of formulation and process parameters in twin screw hot-melt granulation coupled with in-line particle size analysis of sustained release HPMC granules,” presented at the 11th World Meeting on Pharmaceutics, Biopharmaceutics and  Pharmaceutical Technology, Granada (Spanien), 2018.","short":"G. Kutz, M. Repka, P. Thipsay, in: 2018.","chicago-de":"Kutz, Gerd, M. Repka und P. Thipsay. 2018. Impact of formulation and process parameters in twin screw hot-melt granulation coupled with in-line particle size analysis of sustained release HPMC granules. In: .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kutz, Gerd</span> ; <span style=\"font-variant:small-caps;\">Repka, M.</span> ; <span style=\"font-variant:small-caps;\">Thipsay, P.</span>: Impact of formulation and process parameters in twin screw hot-melt granulation coupled with in-line particle size analysis of sustained release HPMC granules. In: , 2018","van":"Kutz G, Repka M, Thipsay P. Impact of formulation and process parameters in twin screw hot-melt granulation coupled with in-line particle size analysis of sustained release HPMC granules. In 2018.","bjps":"<b>Kutz G, Repka M and Thipsay P</b> (2018) Impact of Formulation and Process Parameters in Twin Screw Hot-Melt Granulation Coupled with in-Line Particle Size Analysis of Sustained Release HPMC Granules.","havard":"G. Kutz, M. Repka, P. Thipsay, Impact of formulation and process parameters in twin screw hot-melt granulation coupled with in-line particle size analysis of sustained release HPMC granules, in: 2018.","mla":"Kutz, Gerd, et al. <i>Impact of Formulation and Process Parameters in Twin Screw Hot-Melt Granulation Coupled with in-Line Particle Size Analysis of Sustained Release HPMC Granules</i>. 2018.","ufg":"<b>Kutz, Gerd/Repka, M./Thipsay, P.</b>: Impact of formulation and process parameters in twin screw hot-melt granulation coupled with in-line particle size analysis of sustained release HPMC granules, in: o. Hg.: o. O. 2018.","apa":"Kutz, G., Repka, M., &#38; Thipsay, P. (2018). <i>Impact of formulation and process parameters in twin screw hot-melt granulation coupled with in-line particle size analysis of sustained release HPMC granules</i>. 11th World Meeting on Pharmaceutics, Biopharmaceutics and  Pharmaceutical Technology, Granada (Spanien).","chicago":"Kutz, Gerd, M. Repka, and P. Thipsay. “Impact of Formulation and Process Parameters in Twin Screw Hot-Melt Granulation Coupled with in-Line Particle Size Analysis of Sustained Release HPMC Granules,” 2018."},"department":[{"_id":"DEP4022"}],"conference":{"location":"Granada (Spanien)","name":"11th World Meeting on Pharmaceutics, Biopharmaceutics and  Pharmaceutical Technology","end_date":"20218-03-22","start_date":"2018-03-19"},"author":[{"first_name":"Gerd","id":"12015","last_name":"Kutz","full_name":"Kutz, Gerd"},{"full_name":"Repka, M.","first_name":"M.","last_name":"Repka"},{"first_name":"P.","full_name":"Thipsay, P.","last_name":"Thipsay"}],"year":"2018","status":"public","date_created":"2020-06-05T18:00:01Z","type":"conference","date_updated":"2024-10-31T10:36:26Z","user_id":"83781","_id":"2879","language":[{"iso":"eng"}]},{"date_created":"2020-06-05T18:02:53Z","type":"conference","date_updated":"2024-10-31T11:53:09Z","user_id":"83781","_id":"2881","language":[{"iso":"eng"}],"title":"Real time control of melt granulation processes by inline measurement of particle size","publication_status":"published","citation":{"chicago-de":"Kutz, Gerd, R. Daniels und Dominic Kamke. 2018. Real time control of melt granulation processes by inline measurement of particle size. In: .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kutz, Gerd</span> ; <span style=\"font-variant:small-caps;\">Daniels, R.</span> ; <span style=\"font-variant:small-caps;\">Kamke, Dominic</span>: Real time control of melt granulation processes by inline measurement of particle size. In: , 2018","short":"G. Kutz, R. Daniels, D. Kamke, in: 2018.","ufg":"<b>Kutz, Gerd/Daniels, R./Kamke, Dominic</b>: Real time control of melt granulation processes by inline measurement of particle size, in: o. Hg.: o. O. 2018.","mla":"Kutz, Gerd, et al. <i>Real Time Control of Melt Granulation Processes by Inline Measurement of Particle Size</i>. 2018.","havard":"G. Kutz, R. Daniels, D. Kamke, Real time control of melt granulation processes by inline measurement of particle size, in: 2018.","bjps":"<b>Kutz G, Daniels R and Kamke D</b> (2018) Real Time Control of Melt Granulation Processes by Inline Measurement of Particle Size.","van":"Kutz G, Daniels R, Kamke D. Real time control of melt granulation processes by inline measurement of particle size. In 2018.","ama":"Kutz G, Daniels R, Kamke D. Real time control of melt granulation processes by inline measurement of particle size. In: ; 2018.","chicago":"Kutz, Gerd, R. Daniels, and Dominic Kamke. “Real Time Control of Melt Granulation Processes by Inline Measurement of Particle Size,” 2018.","apa":"Kutz, G., Daniels, R., &#38; Kamke, D. (2018). <i>Real time control of melt granulation processes by inline measurement of particle size</i>. 11th World Meeting on Pharmaceutics, Biopharmaceutics and  Pharmaceutical Technology, Granada (Spanien).","ieee":"G. Kutz, R. Daniels, and D. Kamke, “Real time control of melt granulation processes by inline measurement of particle size,” presented at the 11th World Meeting on Pharmaceutics, Biopharmaceutics and  Pharmaceutical Technology, Granada (Spanien), 2018."},"department":[{"_id":"DEP4022"}],"conference":{"name":"11th World Meeting on Pharmaceutics, Biopharmaceutics and  Pharmaceutical Technology","location":"Granada (Spanien)","start_date":"2018-03-19","end_date":"2018-03-22"},"author":[{"last_name":"Kutz","first_name":"Gerd","full_name":"Kutz, Gerd","id":"12015"},{"last_name":"Daniels","full_name":"Daniels, R.","first_name":"R."},{"id":"59061","full_name":"Kamke, Dominic","last_name":"Kamke","first_name":"Dominic"}],"year":"2018","status":"public"},{"title":"Fluid bed drying – Characterization by DoE","publication_status":"published","citation":{"apa":"Kutz, G., Schlebach, S., &#38; Kamke, D. (2018). <i>Fluid bed drying – Characterization by DoE</i>. 11th World Meeting on Pharmaceutics, Biopharmaceutics and  Pharmaceutical Technology, Granada (Spanien).","chicago":"Kutz, Gerd, Simon Schlebach, and Dominic Kamke. “Fluid Bed Drying – Characterization by DoE,” 2018.","van":"Kutz G, Schlebach S, Kamke D. Fluid bed drying – Characterization by DoE. In 2018.","havard":"G. Kutz, S. Schlebach, D. Kamke, Fluid bed drying – Characterization by DoE, in: 2018.","mla":"Kutz, Gerd, et al. <i>Fluid Bed Drying – Characterization by DoE</i>. 2018.","bjps":"<b>Kutz G, Schlebach S and Kamke D</b> (2018) Fluid Bed Drying – Characterization by DoE.","ufg":"<b>Kutz, Gerd/Schlebach, Simon/Kamke, Dominic</b>: Fluid bed drying – Characterization by DoE, in: o. Hg.: o. O. 2018.","short":"G. Kutz, S. Schlebach, D. Kamke, in: 2018.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kutz, Gerd</span> ; <span style=\"font-variant:small-caps;\">Schlebach, Simon</span> ; <span style=\"font-variant:small-caps;\">Kamke, Dominic</span>: Fluid bed drying – Characterization by DoE. In: , 2018","chicago-de":"Kutz, Gerd, Simon Schlebach und Dominic Kamke. 2018. Fluid bed drying – Characterization by DoE. In: .","ieee":"G. Kutz, S. Schlebach, and D. Kamke, “Fluid bed drying – Characterization by DoE,” presented at the 11th World Meeting on Pharmaceutics, Biopharmaceutics and  Pharmaceutical Technology, Granada (Spanien), 2018.","ama":"Kutz G, Schlebach S, Kamke D. Fluid bed drying – Characterization by DoE. In: ; 2018."},"department":[{"_id":"DEP4022"}],"conference":{"name":"11th World Meeting on Pharmaceutics, Biopharmaceutics and  Pharmaceutical Technology","location":"Granada (Spanien)","end_date":"2018-03-22","start_date":"2018-03-19"},"author":[{"full_name":"Kutz, Gerd","last_name":"Kutz","first_name":"Gerd","id":"12015"},{"first_name":"Simon","full_name":"Schlebach, Simon","id":"48345","last_name":"Schlebach"},{"full_name":"Kamke, Dominic","first_name":"Dominic","last_name":"Kamke","id":"59061"}],"year":"2018","status":"public","date_created":"2020-06-05T18:05:32Z","type":"conference","date_updated":"2024-10-31T13:38:56Z","user_id":"83781","language":[{"iso":"eng"}],"_id":"2883"},{"status":"public","department":[{"_id":"DEP4022"}],"conference":{"location":"San Diego (USA)","name":"AAPS Annual Meeting and Exposition","start_date":"2017-11-12","end_date":"2017-11-15"},"year":"2017","author":[{"last_name":"Daniels","first_name":"R.","full_name":"Daniels, R."},{"full_name":"Kamke, Dominic","first_name":"Dominic","last_name":"Kamke","id":"82841"},{"full_name":"Kutz, Gerd","id":"12015","last_name":"Kutz","first_name":"Gerd"}],"publication_status":"published","citation":{"ieee":"R. Daniels, D. Kamke, and G. Kutz, <i>An Innovative Tool For Real-Time Particle Size Measurement During High-Shear Melt Granulation</i>. 2017.","ama":"Daniels R, Kamke D, Kutz G. <i>An Innovative Tool For Real-Time Particle Size Measurement During High-Shear Melt Granulation</i>.; 2017.","apa":"Daniels, R., Kamke, D., &#38; Kutz, G. (2017). <i>An Innovative Tool For Real-Time Particle Size Measurement During High-Shear Melt Granulation</i>. AAPS Annual Meeting and Exposition, San Diego (USA).","chicago":"Daniels, R., Dominic Kamke, and Gerd Kutz. <i>An Innovative Tool For Real-Time Particle Size Measurement During High-Shear Melt Granulation</i>, 2017.","van":"Daniels R, Kamke D, Kutz G. An Innovative Tool For Real-Time Particle Size Measurement During High-Shear Melt Granulation. 2017.","mla":"Daniels, R., et al. <i>An Innovative Tool For Real-Time Particle Size Measurement During High-Shear Melt Granulation</i>. 2017.","havard":"R. Daniels, D. Kamke, G. 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Chemie, Anlagen, Verfahren : CAV ; die Zeitschrift für Chemie- und Pharmatechnik . 2010;43(8):54–5.","ufg":"<b>Feldbusch, Natalja u. a.</b>: Zwei auf einen Streich - Schnelle Identifikation wichtiger Parameter mittels Versuchsplanung, in: <i>Chemie, Anlagen, Verfahren : CAV ; die Zeitschrift für Chemie- und Pharmatechnik </i> 43 (2010), H. 8,  S. 54–55.","mla":"Feldbusch, Natalja, et al. “Zwei auf einen Streich - Schnelle Identifikation wichtiger Parameter mittels Versuchsplanung.” <i>Chemie, Anlagen, Verfahren : CAV ; die Zeitschrift für Chemie- und Pharmatechnik </i>, vol. 43, no. 8, 2010, pp. 54–55.","bjps":"<b>Feldbusch N <i>et al.</i></b> (2010) Zwei auf einen Streich - Schnelle Identifikation wichtiger Parameter mittels Versuchsplanung. <i>Chemie, Anlagen, Verfahren : CAV ; die Zeitschrift für Chemie- und Pharmatechnik </i> <b>43</b>, 54–55.","havard":"N. Feldbusch, G. Kutz, S. Feiler, P. Solot, Zwei auf einen Streich - Schnelle Identifikation wichtiger Parameter mittels Versuchsplanung, Chemie, Anlagen, Verfahren : CAV ; die Zeitschrift für Chemie- und Pharmatechnik . 43 (2010) 54–55.","apa":"Feldbusch, N., Kutz, G., Feiler, S., &#38; Solot, P. (2010). Zwei auf einen Streich - Schnelle Identifikation wichtiger Parameter mittels Versuchsplanung. <i>Chemie, Anlagen, Verfahren : CAV ; die Zeitschrift für Chemie- und Pharmatechnik </i>, <i>43</i>(8), 54–55.","chicago":"Feldbusch, Natalja, Gerd Kutz, Stefanie Feiler, and Philippe Solot. “Zwei auf einen Streich - Schnelle Identifikation wichtiger Parameter mittels Versuchsplanung.” <i>Chemie, Anlagen, Verfahren : CAV ; die Zeitschrift für Chemie- und Pharmatechnik </i> 43, no. 8 (2010): 54–55."}},{"user_id":"83781","intvolume":"        58","type":"industry_journal_article","place":"München-Deisenhofen","_id":"4436","publication_status":"published","publisher":"Dustri-Verlag Dr. Karl Feistle GmbH","department":[{"_id":"DEP4022"}],"issue":"Nr. 2","date_updated":"2024-11-21T15:19:50Z","date_created":"2021-01-20T07:45:52Z","publication_identifier":{"eissn":["1616-7090"],"issn":["1438-776X "]},"publication":"Dermatologie in Beruf und Umwelt","language":[{"iso":"eng"}],"volume":58,"citation":{"ufg":"<b>Antonov, D. u. a.</b>: Development of a test model for occupational hand-cleansers to quantify cleansing efficacy in relation to irritant otential, in: <i>Dermatologie in Beruf und Umwelt</i> 58 (2010), H. Nr. 2,  S. S. 90.","bjps":"<b>Antonov D <i>et al.</i></b> (2010) Development of a Test Model for Occupational Hand-Cleansers to Quantify Cleansing Efficacy in Relation to Irritant Otential. <i>Dermatologie in Beruf und Umwelt</i> <b>58</b>, S. 90.","havard":"D. Antonov, F. Seyfarth, S. Schliemann, F. Terhaer, M. Bock, S.M. John, P. Kleesz, D. Pohlmann, G. Kutz, P. Elsner, Development of a test model for occupational hand-cleansers to quantify cleansing efficacy in relation to irritant otential, Dermatologie in Beruf Und Umwelt. 58 (2010) S. 90.","mla":"Antonov, D., et al. “Development of a Test Model for Occupational Hand-Cleansers to Quantify Cleansing Efficacy in Relation to Irritant Otential.” <i>Dermatologie in Beruf Und Umwelt</i>, vol. 58, no. Nr. 2, 2010, p. S. 90.","van":"Antonov D, Seyfarth F, Schliemann S, Terhaer F, Bock M, John SM, et al. Development of a test model for occupational hand-cleansers to quantify cleansing efficacy in relation to irritant otential. 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Antonov <i>et al.</i>, “Development of a test model for occupational hand-cleansers to quantify cleansing efficacy in relation to irritant otential,” <i>Dermatologie in Beruf und Umwelt</i>, vol. 58, no. Nr. 2, p. S. 90, 2010.","chicago-de":"Antonov, D., F. Seyfarth, S. Schliemann, F. Terhaer, M. Bock, S. M. John, P. Kleesz, D. Pohlmann, Gerd Kutz und P. Elsner. 2010. Development of a test model for occupational hand-cleansers to quantify cleansing efficacy in relation to irritant otential. <i>Dermatologie in Beruf und Umwelt</i> 58, Nr. Nr. 2: S. 90.","din1505-2-1":"<span style=\"font-variant:small-caps;\"><span style=\"font-variant:small-caps;\">Antonov, D.</span> ; <span style=\"font-variant:small-caps;\">Seyfarth, F.</span> ; <span style=\"font-variant:small-caps;\">Schliemann, S.</span> ; <span style=\"font-variant:small-caps;\">Terhaer, F.</span> ; <span style=\"font-variant:small-caps;\">Bock, M.</span> ; <span style=\"font-variant:small-caps;\">John, S. M.</span> ; <span style=\"font-variant:small-caps;\">Kleesz, P.</span> ; <span style=\"font-variant:small-caps;\">Pohlmann, D.</span> ; u. a.</span>: Development of a test model for occupational hand-cleansers to quantify cleansing efficacy in relation to irritant otential. In: <i>Dermatologie in Beruf und Umwelt</i> Bd. 58. München-Deisenhofen, Dustri-Verlag Dr. Karl Feistle GmbH (2010), Nr. Nr. 2, S. S. 90","short":"D. Antonov, F. Seyfarth, S. Schliemann, F. Terhaer, M. Bock, S.M. John, P. Kleesz, D. Pohlmann, G. Kutz, P. Elsner, Dermatologie in Beruf Und Umwelt 58 (2010) S. 90."},"title":"Development of a test model for occupational hand-cleansers to quantify cleansing efficacy in relation to irritant otential","page":"S. 90","status":"public","author":[{"first_name":"D.","full_name":"Antonov, D.","last_name":"Antonov"},{"full_name":"Seyfarth, F.","last_name":"Seyfarth","first_name":"F."},{"first_name":"S.","last_name":"Schliemann","full_name":"Schliemann, S."},{"last_name":"Terhaer","first_name":"F.","full_name":"Terhaer, F."},{"first_name":"M.","full_name":"Bock, M.","last_name":"Bock"},{"last_name":"John","full_name":"John, S. M.","first_name":"S. M."},{"last_name":"Kleesz","first_name":"P.","full_name":"Kleesz, P."},{"full_name":"Pohlmann, D.","last_name":"Pohlmann","first_name":"D."},{"id":"12015","first_name":"Gerd","last_name":"Kutz","full_name":"Kutz, Gerd"},{"full_name":"Elsner, P.","first_name":"P.","last_name":"Elsner"}],"year":"2010"},{"conference":{"end_date":"2010-12-16","start_date":"2010-12-15","name":"APV-Fortbildungskurz Nr.: 6344","location":"Hochschule-Ostwestfalen Detmold"},"department":[{"_id":"DEP4022"}],"author":[{"first_name":"Gerd","id":"12015","last_name":"Kutz","full_name":"Kutz, Gerd"}],"year":"2010","status":"public","title":"Emulsionen","citation":{"ieee":"G. Kutz, “Emulsionen,” presented at the APV-Fortbildungskurz Nr.: 6344, Hochschule-Ostwestfalen Detmold, 2010.","ama":"Kutz G. Emulsionen. In: ; 2010.","chicago":"Kutz, Gerd. “Emulsionen,” 2010.","apa":"Kutz, G. (2010). <i>Emulsionen</i>. APV-Fortbildungskurz Nr.: 6344, Hochschule-Ostwestfalen Detmold.","havard":"G. 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Kutz, “Praktikum: Aseptisches Arbeiten,” presented at the APV-Fortbildungskurs Nr.: 6335 , Hochschule Ostwestfalen-Lippe Detmold, 2010.","short":"G. Kutz, in: 2010.","chicago-de":"Kutz, Gerd. 2010. Praktikum: Aseptisches Arbeiten. In: .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kutz, Gerd</span>: Praktikum: Aseptisches Arbeiten. In: , 2010","van":"Kutz G. Praktikum: Aseptisches Arbeiten. In 2010.","mla":"Kutz, Gerd. <i>Praktikum: Aseptisches Arbeiten</i>. 2010.","bjps":"<b>Kutz G</b> (2010) Praktikum: Aseptisches Arbeiten.","havard":"G. Kutz, Praktikum: Aseptisches Arbeiten, in: 2010.","ufg":"<b>Kutz, Gerd</b>: Praktikum: Aseptisches Arbeiten, in: o. Hg.: o. O. 2010.","apa":"Kutz, G. (2010). <i>Praktikum: Aseptisches Arbeiten</i>. APV-Fortbildungskurs Nr.: 6335 , Hochschule Ostwestfalen-Lippe Detmold.","chicago":"Kutz, Gerd. “Praktikum: Aseptisches Arbeiten,” 2010."},"language":[{"iso":"eng"}],"_id":"4473","type":"conference","date_created":"2021-01-20T09:26:52Z","date_updated":"2024-05-24T10:53:42Z","user_id":"83778"},{"publication_status":"published","abstract":[{"text":"The anaplerotic odd-medium-chain triglyceride triheptanoin is used in clinical trials for the chronic dietary treatment of patients with long-chain fatty acid oxidation disorders. We previously showed (Kinman RP, Kasumov T, Jobbins KA, Thomas KR, Adams JE, Brunengraber LN, Kutz G, Brewer WU, Roe CR, Brunengraber H. Am J Physiol Endocrinol Metab 291: E860–E866, 2006) that the intravenous infusion of triheptanoin increases lipolysis traced by the turnover of glycerol. In this study, we tested whether lipolysis induced by triheptanoin infusion is accompanied by the potentially harmful release of long-chain fatty acids. Rats were infused with heptanoate ± glycerol or triheptanoin. Intravenous infusion of triheptanoin at 40% of caloric requirement markedly increased glycerol endogenous Ra but not oleate endogenous Ra. Thus, the activation of lipolysis was balanced by fatty acid reesterification in the same cells. The liver acyl-CoA profile showed the accumulation of intermediates of heptanoate β-oxidation and C5-ketogenesis and a decrease in free CoA but no evidence of metabolic perturbation of liver metabolism such as propionyl overload. Our data suggest that triheptanoin, administered either intravenously or intraduodenally, could be used for intensive care and nutritional support of metabolically decompensated long-chain fatty acid oxidation disorders.","lang":"eng"}],"issue":"2","department":[{"_id":"DEP4022"}],"publisher":"APS","quality_controlled":"1","type":"journal_article","intvolume":"       298","user_id":"83781","_id":"2630","doi":"https://doi.org/10.1152/ajpendo.00384.2009","title":"Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA profile","volume":298,"citation":{"ieee":"L. Gu <i>et al.</i>, “Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA profile,” <i>American journal of physiology : Endocrinology and metabolism</i>, vol. 298, no. 2, pp. E362–E371, 2010, doi: <a href=\"https://doi.org/10.1152/ajpendo.00384.2009\">https://doi.org/10.1152/ajpendo.00384.2009</a>.","ama":"Gu L, Zhang GF,  Kombu RS, et al. Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA profile. <i>American journal of physiology : Endocrinology and metabolism</i>. 2010;298(2):E362-E371. doi:<a href=\"https://doi.org/10.1152/ajpendo.00384.2009\">https://doi.org/10.1152/ajpendo.00384.2009</a>","short":"L. Gu, G.-F. Zhang, R.S.  Kombu, F. Allen, G. Kutz, B. Brewer, C.R. Roe, H. Brunengraber, American Journal of Physiology : Endocrinology and Metabolism 298 (2010) E362–E371.","chicago-de":"Gu, Lei, Guo-Fang Zhang, Rajan S.   Kombu, Frederick Allen, Gerd Kutz, Brewer Brewer, Charles R. Roe und Henri Brunengraber. 2010. Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA profile. <i>American journal of physiology : Endocrinology and metabolism</i> 298, Nr. 2: E362–E371. doi:<a href=\"https://doi.org/10.1152/ajpendo.00384.2009\">https://doi.org/10.1152/ajpendo.00384.2009</a>, .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Gu, Lei</span> ; <span style=\"font-variant:small-caps;\">Zhang, Guo-Fang</span> ; <span style=\"font-variant:small-caps;\"> Kombu, Rajan S. </span> ; <span style=\"font-variant:small-caps;\">Allen, Frederick</span> ; <span style=\"font-variant:small-caps;\">Kutz, Gerd</span> ; <span style=\"font-variant:small-caps;\">Brewer, Brewer</span> ; <span style=\"font-variant:small-caps;\">Roe, Charles R.</span> ; <span style=\"font-variant:small-caps;\">Brunengraber, Henri</span>: Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA profile. In: <i>American journal of physiology : Endocrinology and metabolism</i> Bd. 298, APS (2010), Nr. 2, S. E362–E371","apa":"Gu, L., Zhang, G.-F.,  Kombu, R. S., Allen, F., Kutz, G., Brewer, B., Roe, C. R., &#38; Brunengraber, H. (2010). Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA profile. <i>American Journal of Physiology : Endocrinology and Metabolism</i>, <i>298</i>(2), E362–E371. <a href=\"https://doi.org/10.1152/ajpendo.00384.2009\">https://doi.org/10.1152/ajpendo.00384.2009</a>","chicago":"Gu, Lei, Guo-Fang Zhang, Rajan S.   Kombu, Frederick Allen, Gerd Kutz, Brewer Brewer, Charles R. Roe, and Henri Brunengraber. “Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on Lipolysis, Glucose Production and Liver Acyl-CoA Profile.” <i>American Journal of Physiology : Endocrinology and Metabolism</i> 298, no. 2 (2010): E362–71. <a href=\"https://doi.org/10.1152/ajpendo.00384.2009\">https://doi.org/10.1152/ajpendo.00384.2009</a>.","van":"Gu L, Zhang GF,  Kombu RS, Allen F, Kutz G, Brewer B, et al. Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA profile. American journal of physiology : Endocrinology and metabolism. 2010;298(2):E362–71.","bjps":"<b>Gu L <i>et al.</i></b> (2010) Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on Lipolysis, Glucose Production and Liver Acyl-CoA Profile. <i>American journal of physiology : Endocrinology and metabolism</i> <b>298</b>, E362–E371.","mla":"Gu, Lei, et al. “Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on Lipolysis, Glucose Production and Liver Acyl-CoA Profile.” <i>American Journal of Physiology : Endocrinology and Metabolism</i>, vol. 298, no. 2, 2010, pp. E362–71, <a href=\"https://doi.org/10.1152/ajpendo.00384.2009\">https://doi.org/10.1152/ajpendo.00384.2009</a>.","havard":"L. Gu, G.-F. Zhang, R.S.  Kombu, F. Allen, G. Kutz, B. Brewer, C.R. Roe, H. Brunengraber, Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA profile, American Journal of Physiology : Endocrinology and Metabolism. 298 (2010) E362–E371.","ufg":"<b>Gu, Lei u. a.</b>: Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA profile, in: <i>American journal of physiology : Endocrinology and metabolism</i> 298 (2010), H. 2,  S. E362–E371."},"external_id":{"pmid":["19903863"]},"author":[{"first_name":"Lei","last_name":"Gu","full_name":"Gu, Lei"},{"first_name":"Guo-Fang","full_name":"Zhang, Guo-Fang","last_name":"Zhang"},{"full_name":" Kombu, Rajan S. ","last_name":" Kombu","first_name":"Rajan S. 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Hautmodell."},"title":"Hautmodell","status":"public","page":"1","publication_date":"2009-06-11","author":[{"first_name":"Christiane","last_name":"Bruns","full_name":"Bruns, Christiane"},{"first_name":"Gerd","last_name":"Kutz","full_name":"Kutz, Gerd","id":"12015"},{"full_name":"Prinz, Daniela","first_name":"Daniela","last_name":"Prinz"}],"year":"2009","department":[{"_id":"DEP4022"}],"application_date":"2008-11-29","abstract":[{"text":"Vorgeschlagen wird eine Vorrichtung zum Testen von kosmetischen und pharmazeutischen Rohstoffen beinhaltend eine Membran, die über ein Behältnis gespannt wird, welches ein Hydrogel als tragenden Untergrund für die Membran enthält. ","lang":"ger"},{"text":"The invention relates to a device for testing cosmetic and pharmaceutical raw materials, comprising a membrane that is streched over a container that comprises a hydrogel as supporting base for the membrane. ","lang":"eng"}]},{"type":"conference","date_created":"2020-11-20T09:39:44Z","date_updated":"2024-11-26T08:35:30Z","user_id":"83781","_id":"3981","language":[{"iso":"eng"}],"title":"Current Emulsification Techniques","publication_status":"published","citation":{"short":"G. Kutz, in: 2009.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kutz, Gerd</span>: Current Emulsification Techniques. In: , 2009","chicago-de":"Kutz, Gerd. 2009. Current Emulsification Techniques. In: .","van":"Kutz G. Current Emulsification Techniques. In 2009.","ufg":"<b>Kutz, Gerd</b>: Current Emulsification Techniques, in: o. Hg.: o. O. 2009.","bjps":"<b>Kutz G</b> (2009) Current Emulsification Techniques.","havard":"G. Kutz, Current Emulsification Techniques, in: 2009.","mla":"Kutz, Gerd. <i>Current Emulsification Techniques</i>. 2009.","apa":"Kutz, G. (2009). <i>Current Emulsification Techniques</i>. Seminar an der German-Jordanian University, Amman (Jordanien).","chicago":"Kutz, Gerd. “Current Emulsification Techniques,” 2009.","ama":"Kutz G. Current Emulsification Techniques. In: ; 2009.","ieee":"G. Kutz, “Current Emulsification Techniques,” presented at the Seminar an der German-Jordanian University, Amman (Jordanien), 2009."},"department":[{"_id":"DEP4022"}],"conference":{"start_date":"2009-06-01","end_date":"2009-06-01","name":"Seminar an der German-Jordanian University","location":"Amman (Jordanien)"},"author":[{"first_name":"Gerd","last_name":"Kutz","id":"12015","full_name":"Kutz, Gerd"}],"year":"2009","status":"public"},{"volume":33,"citation":{"van":"Kutz G. Aktuelle Rohstoffe und Formulierungsstrategien. In: H. Ziolkowsky GmbH, editor. Innovationen : Herausforderungen und Chancen. Augsburg: Verlag für chemische Industrie; 2009. (Kosmetik-Jahrbuch ; vol. 33).","ufg":"<b>Kutz, Gerd</b>: Aktuelle Rohstoffe und Formulierungsstrategien, in: <i>H. Ziolkowsky GmbH (Hg.)</i>: Innovationen : Herausforderungen und Chancen, Bd. 33, Augsburg 2009 (Kosmetik-Jahrbuch ).","havard":"G. Kutz, Aktuelle Rohstoffe und Formulierungsstrategien, in: H. Ziolkowsky GmbH (Ed.), Innovationen : Herausforderungen und Chancen, Verlag für chemische Industrie, Augsburg, 2009.","bjps":"<b>Kutz G</b> (2009) Aktuelle Rohstoffe und Formulierungsstrategien. In H. Ziolkowsky GmbH (ed.), <i>Innovationen : Herausforderungen und Chancen</i>, vol. 33. Augsburg: Verlag für chemische Industrie.","mla":"Kutz, Gerd. “Aktuelle Rohstoffe und Formulierungsstrategien.” <i>Innovationen : Herausforderungen und Chancen</i>, edited by H. Ziolkowsky GmbH, vol. 33, Verlag für chemische Industrie, 2009.","apa":"Kutz, G. (2009). Aktuelle Rohstoffe und Formulierungsstrategien. In H. Ziolkowsky GmbH (Ed.), <i>Innovationen : Herausforderungen und Chancen</i> (Vol. 33). Verlag für chemische Industrie.","chicago":"Kutz, Gerd. “Aktuelle Rohstoffe und Formulierungsstrategien.” In <i>Innovationen : Herausforderungen und Chancen</i>, edited by H. Ziolkowsky GmbH, Vol. 33. Kosmetik-Jahrbuch . Augsburg: Verlag für chemische Industrie, 2009.","short":"G. Kutz, in: H. Ziolkowsky GmbH (Ed.), Innovationen : Herausforderungen und Chancen, Verlag für chemische Industrie, Augsburg, 2009.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kutz, Gerd</span>: Aktuelle Rohstoffe und Formulierungsstrategien. In: <span style=\"font-variant:small-caps;\">H. Ziolkowsky GmbH</span> (Hrsg.): <i>Innovationen : Herausforderungen und Chancen</i>, <i>Kosmetik-Jahrbuch </i>. Bd. 33. Augsburg : Verlag für chemische Industrie, 2009","chicago-de":"Kutz, Gerd. 2009. Aktuelle Rohstoffe und Formulierungsstrategien. In: <i>Innovationen : Herausforderungen und Chancen</i>, hg. von H. Ziolkowsky GmbH, 33:. Kosmetik-Jahrbuch . Augsburg: Verlag für chemische Industrie.","ama":"Kutz G. Aktuelle Rohstoffe und Formulierungsstrategien. In: H. Ziolkowsky GmbH, ed. <i>Innovationen : Herausforderungen und Chancen</i>. Vol 33. Kosmetik-Jahrbuch . Verlag für chemische Industrie; 2009.","ieee":"G. Kutz, “Aktuelle Rohstoffe und Formulierungsstrategien,” in <i>Innovationen : Herausforderungen und Chancen</i>, vol. 33, H. Ziolkowsky GmbH, Ed. Augsburg: Verlag für chemische Industrie, 2009."},"publication_status":"published","series_title":"Kosmetik-Jahrbuch ","title":"Aktuelle Rohstoffe und Formulierungsstrategien","status":"public","publisher":"Verlag für chemische Industrie","year":"2009","author":[{"last_name":"Kutz","first_name":"Gerd","full_name":"Kutz, Gerd","id":"12015"}],"department":[{"_id":"DEP4022"}],"user_id":"83781","date_updated":"2024-11-26T08:51:20Z","corporate_editor":["H. Ziolkowsky GmbH"],"intvolume":"        33","publication":"Innovationen : Herausforderungen und Chancen","publication_identifier":{"isbn":["978-3-87846-271-2"]},"type":"book_chapter","date_created":"2020-11-20T09:57:20Z","place":"Augsburg","language":[{"iso":"ger"}],"_id":"3985"},{"_id":"2637","doi":" https://doi.org/10.1096/fasebj.23.1_supplement.506.3","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0892-6638 "],"eissn":["1530-6860"]},"publication":"  The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology","date_created":"2020-05-27T08:21:35Z","type":"journal_article","intvolume":"        23","user_id":"83781","date_updated":"2024-11-19T10:22:09Z","issue":"4","abstract":[{"lang":"eng","text":"Anaplerotic TH (glycerol triheptanoate) is used for the chronic oral treatment of long-chain fatty acid oxidation disorders (FOD). To test whether TH could also be used for the acute intravenous treatment of decompensated FOD patients, we investigated the metabolism and metabolic effects of triheptanoin emulsion administered parenterally or enterally. Rats were infused with TH emulsion (intravenously or intragastrically). Stable isotope tracers were infused intravenously to measure the rates of appearance (Ra) of plasma glucose, glycerol and fatty acids. Surprisingly, intravenous infusion of triheptanoin markedly increased glycerol Ra but not oleate Ra. This indicated that massive lipolysis induced by intravenous TH was not accompanied by the release of long-chain fatty acids from adipocytes. This probably results from the contribution of anaplerotic propionyl-CoA moiety of heptanoate to glyceroneogenesis in adipocytes, generating sufficient amounts of glycerol-3-phosphate to re-esterify the fatty acids derived from stimulated lipolysis. The intraduodenal infusion of TH did not induce lipolysis because TH was hydrolyzed in the gut. Our data support the use of intravenous TH emulsion for the acute treatment of FOD patients (for whom the release of fatty acids from adipocytes would be harmful). Supported by NIH."}],"author":[{"last_name":"Gu","first_name":"Lei","full_name":"Gu, Lei"},{"first_name":"Guofang","last_name":"Zhang","full_name":"Zhang, Guofang"},{"last_name":"S. Kombu","full_name":"S. Kombu, Rajan","first_name":"Rajan"},{"last_name":"Kutz","id":"12015","full_name":"Kutz, Gerd","first_name":"Gerd"},{"last_name":"Brewer","first_name":"Wolf-Ulrich","full_name":"Brewer, Wolf-Ulrich"},{"last_name":"Roe","first_name":"Charles R.","full_name":"Roe, Charles R."},{"first_name":"Henri","last_name":"Brunengraber","full_name":"Brunengraber, Henri"}],"year":"2009","department":[{"_id":"DEP4022"}],"publisher":"Wiley","status":"public","page":"506.3","title":"Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal rats","citation":{"din1505-2-1":"<span style=\"font-variant:small-caps;\">Gu, Lei</span> ; <span style=\"font-variant:small-caps;\">Zhang, Guofang</span> ; <span style=\"font-variant:small-caps;\">S. Kombu, Rajan</span> ; <span style=\"font-variant:small-caps;\">Kutz, Gerd</span> ; <span style=\"font-variant:small-caps;\">Brewer, Wolf-Ulrich</span> ; <span style=\"font-variant:small-caps;\">Roe, Charles R.</span> ; <span style=\"font-variant:small-caps;\">Brunengraber, Henri</span>: Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal rats. In: <i>  The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology</i> Bd. 23, Wiley (2009), Nr. 4, S. 506.3","chicago-de":"Gu, Lei, Guofang Zhang, Rajan S. Kombu, Gerd Kutz, Wolf-Ulrich Brewer, Charles R. Roe und Henri Brunengraber. 2009. Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal rats. <i>  The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology</i> 23, Nr. 4: 506.3. doi:<a href=\"https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3\"> https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>, .","short":"L. Gu, G. Zhang, R. S. Kombu, G. Kutz, W.-U. Brewer, C.R. Roe, H. Brunengraber,   The FASEB Journal : The Official Journal of the Federation of American Societies for Experimental Biology 23 (2009) 506.3.","ufg":"<b>Gu, Lei u. a.</b>: Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal rats, in: <i>  The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology</i> 23 (2009), H. 4,  S. 506.3.","bjps":"<b>Gu L <i>et al.</i></b> (2009) Metabolism and Metabolic Effects of Anaplerotic Triheptanoin (TH) in Normal Rats. <i>  The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology</i> <b>23</b>, 506.3.","mla":"Gu, Lei, et al. “Metabolism and Metabolic Effects of Anaplerotic Triheptanoin (TH) in Normal Rats.” <i>  The FASEB Journal : The Official Journal of the Federation of American Societies for Experimental Biology</i>, vol. 23, no. 4, 2009, p. 506.3, <a href=\"https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3\">https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>.","havard":"L. Gu, G. Zhang, R. S. Kombu, G. Kutz, W.-U. Brewer, C.R. Roe, H. Brunengraber, Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal rats,   The FASEB Journal : The Official Journal of the Federation of American Societies for Experimental Biology. 23 (2009) 506.3.","van":"Gu L, Zhang G, S. Kombu R, Kutz G, Brewer WU, Roe CR, et al. Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal rats.   The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology. 2009;23(4):506.3.","chicago":"Gu, Lei, Guofang Zhang, Rajan S. Kombu, Gerd Kutz, Wolf-Ulrich Brewer, Charles R. Roe, and Henri Brunengraber. “Metabolism and Metabolic Effects of Anaplerotic Triheptanoin (TH) in Normal Rats.” <i>  The FASEB Journal : The Official Journal of the Federation of American Societies for Experimental Biology</i> 23, no. 4 (2009): 506.3. <a href=\"https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3\">https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>.","apa":"Gu, L., Zhang, G., S. Kombu, R., Kutz, G., Brewer, W.-U., Roe, C. R., &#38; Brunengraber, H. (2009). Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal rats. <i>  The FASEB Journal : The Official Journal of the Federation of American Societies for Experimental Biology</i>, <i>23</i>(4), 506.3. <a href=\"https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3\">https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>","ama":"Gu L, Zhang G, S. Kombu R, et al. Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal rats. <i>  The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology</i>. 2009;23(4):506.3. doi:<a href=\"https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3\"> https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>","ieee":"L. Gu <i>et al.</i>, “Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal rats,” <i>  The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology</i>, vol. 23, no. 4, p. 506.3, 2009, doi: <a href=\"https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3\"> https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>."},"volume":23,"publication_status":"published"},{"title":"Process analysis of fluid bed granulation using risk assessment and design of experiments","publication_status":"published","citation":{"van":"Kutz G, Liping L, Li D. 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H.  Müller, D. Prinz und Gerd Kutz. 2006. <i>Identification of topical excipients with high performance spreadabilit</i>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Bruns, Christina</span> ; <span style=\"font-variant:small-caps;\">Müller, R. H. </span> ; <span style=\"font-variant:small-caps;\">Prinz, D.</span> ; <span style=\"font-variant:small-caps;\">Kutz, Gerd</span>: <i>Identification of topical excipients with high performance spreadabilit</i>, 2006","short":"C. Bruns, R.H. Müller, D. Prinz, G. Kutz, Identification of Topical Excipients with High Performance Spreadabilit, 2006.","chicago":"Bruns, Christina, R. H.  Müller, D. Prinz, and Gerd Kutz. <i>Identification of Topical Excipients with High Performance Spreadabilit</i>, 2006.","apa":"Bruns, C., Müller, R. H., Prinz, D., &#38; Kutz, G. (2006). <i>Identification of topical excipients with high performance spreadabilit</i>. 5th World Meeting on Pharmaceutics Biopharmaceutics and Pharmaceutical Technology, Genf.","havard":"C. Bruns, R.H. Müller, D. Prinz, G. Kutz, Identification of topical excipients with high performance spreadabilit, 2006.","mla":"Bruns, Christina, et al. <i>Identification of Topical Excipients with High Performance Spreadabilit</i>. 2006.","bjps":"<b>Bruns C <i>et al.</i></b> (2006) <i>Identification of Topical Excipients with High Performance Spreadabilit</i>. .","ufg":"<b>Bruns, Christina u. a.</b>: Identification of topical excipients with high performance spreadabilit, o. O. 2006.","van":"Bruns C, Müller RH, Prinz D, Kutz G. Identification of topical excipients with high performance spreadabilit. 2006.","ieee":"C. Bruns, R. H. Müller, D. Prinz, and G. Kutz, <i>Identification of topical excipients with high performance spreadabilit</i>. 2006.","ama":"Bruns C, Müller RH, Prinz D, Kutz G. <i>Identification of Topical Excipients with High Performance Spreadabilit</i>.; 2006."},"title":"Identification of topical excipients with high performance spreadabilit","status":"public","conference":{"location":"Genf","name":"5th World Meeting on Pharmaceutics Biopharmaceutics and Pharmaceutical Technology","end_date":"2006-03-30","start_date":"2006-03-27"},"department":[{"_id":"DEP4022"}],"author":[{"full_name":"Bruns, Christina","first_name":"Christina","last_name":"Bruns","id":"72986"},{"first_name":"R. H. ","last_name":"Müller","full_name":"Müller, R. H. "},{"last_name":"Prinz","full_name":"Prinz, D.","first_name":"D."},{"id":"12015","last_name":"Kutz","full_name":"Kutz, Gerd","first_name":"Gerd"}],"year":"2006","main_file_link":[{"url":"https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://www.th-owl.de/fb4/fileadmin/download/06-Pharmatechnik/Kutz/49small.pdf&ved=2ahUKEwi7n4SqiPqJAxUPy7sIHXufICIQFnoECCMQAQ&usg=AOvVaw2_naBJudQst76inRz6pwch"}]},{"date_created":"2020-12-01T09:10:13Z","type":"conference","user_id":"83781","date_updated":"2024-11-26T10:36:59Z","_id":"4134","keyword":["Scientific lecture"],"language":[{"iso":"eng"}],"title":"Modern formulation concepts with actual raw materials","citation":{"short":"G. Kutz, in: 2006.","chicago-de":"Kutz, Gerd. 2006. Modern formulation concepts with actual raw materials. In: .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kutz, Gerd</span>: Modern formulation concepts with actual raw materials. In: , 2006","apa":"Kutz, G. (2006). <i>Modern formulation concepts with actual raw materials</i>. 2nd Emulsion Days , Zürich (Schweiz).","ieee":"G. Kutz, “Modern formulation concepts with actual raw materials,” presented at the 2nd Emulsion Days , Zürich (Schweiz), 2006.","chicago":"Kutz, Gerd. “Modern Formulation Concepts with Actual Raw Materials,” 2006.","van":"Kutz G. Modern formulation concepts with actual raw materials. In 2006.","ama":"Kutz G. Modern formulation concepts with actual raw materials. In: ; 2006.","ufg":"<b>Kutz, Gerd</b>: Modern formulation concepts with actual raw materials, in: o. Hg.: o. O. 2006.","havard":"G. Kutz, Modern formulation concepts with actual raw materials, in: 2006.","mla":"Kutz, Gerd. <i>Modern Formulation Concepts with Actual Raw Materials</i>. 2006.","bjps":"<b>Kutz G</b> (2006) Modern Formulation Concepts with Actual Raw Materials."},"publication_status":"published","year":"2006","author":[{"first_name":"Gerd","id":"12015","full_name":"Kutz, Gerd","last_name":"Kutz"}],"department":[{"_id":"DEP4022"}],"conference":{"name":"2nd Emulsion Days ","location":"Zürich (Schweiz)","end_date":"2206-11-17","start_date":"2006-11-17"},"status":"public"},{"publication_status":"published","publisher":"APS","quality_controlled":"1","issue":"4","abstract":[{"text":"A new chronic treatment for inherited disorders of long-chain fatty acid oxidation involves administering up to one-third of dietary calories as triheptanoin, a medium-odd-chain triglyceride (Roe CR, Sweetman L, Roe DS, David F, and Brunengraber H. J Clin Invest 110: 259–269, 2002). Heptanoate and C5-ketone bodies derived from its partial oxidation in liver are precursors of anaplerotic propionyl-CoA in peripheral tissues. It was hypothesized that increasing anaplerosis in peripheral tissues would boost energy production. In the present study, we tested the potential of a triheptanoin emulsion as an intravenous nutrient. Normal rats were infused with triheptanoin intravenously or intraduodenally at up to 40% of caloric requirement. The blood concentration ratio (heptanoate/C5-ketone bodies) was high with intravenous and low with intraduodenal triheptanoin infusion. During intravenous infusion of triheptanoin, lipolysis was stimulated but appeared compensated by fatty acid reesterification. During intraduodenal infusion of triheptanoin, lipolysis was not stimulated. Our data support the hypothesis that intravenous triheptanoin could be used to treat decompensated patients with long-chain fatty acid oxidation disorders.","lang":"eng"}],"department":[{"_id":"DEP4022"}],"intvolume":"       291","user_id":"83781","type":"journal_article","_id":"2734","doi":"https://doi.org/10.1152/ajpendo.00366.2005","volume":291,"citation":{"ieee":"R. P. Kinman <i>et al.</i>, “Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats,” <i>American journal of physiology, Endocrinology and metabolism</i>, vol. 291, no. 4, pp. E860–E868, 2006, doi: <a href=\"https://doi.org/10.1152/ajpendo.00366.2005\">https://doi.org/10.1152/ajpendo.00366.2005</a>.","ama":"Kinman RP, Kasumov T, Jobbins KA, et al. Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. <i>American journal of physiology, Endocrinology and metabolism</i>. 2006;291(4):E860-E868. doi:<a href=\"https://doi.org/10.1152/ajpendo.00366.2005\">https://doi.org/10.1152/ajpendo.00366.2005</a>","apa":"Kinman, R. P., Kasumov, T., Jobbins, K. A., Thomas, K. R., Adams, J. E., Brunengraber, L. N., Kutz, G., Brewer, W.-U., Roe, C. R., &#38; Brunengraber, H. (2006). Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. <i>American Journal of Physiology, Endocrinology and Metabolism</i>, <i>291</i>(4), E860–E868. <a href=\"https://doi.org/10.1152/ajpendo.00366.2005\">https://doi.org/10.1152/ajpendo.00366.2005</a>","chicago":"Kinman, Renèe P., Takhar Kasumov, Kathryn A. Jobbins, Katherine R. Thomas, Jillian E. Adams, Lisa N. Brunengraber, Gerd Kutz, Wolf-Ulrich  Brewer, Charles R. Roe, and Henri  Brunengraber. “Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats.” <i>American Journal of Physiology, Endocrinology and Metabolism</i> 291, no. 4 (2006): E860–68. <a href=\"https://doi.org/10.1152/ajpendo.00366.2005\">https://doi.org/10.1152/ajpendo.00366.2005</a>.","van":"Kinman RP, Kasumov T, Jobbins KA, Thomas KR, Adams JE, Brunengraber LN, et al. Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. American journal of physiology, Endocrinology and metabolism. 2006;291(4):E860–8.","ufg":"<b>Kinman, Renèe P. u. a.</b>: Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats, in: <i>American journal of physiology, Endocrinology and metabolism</i> 291 (2006), H. 4,  S. E860–E868.","havard":"R.P. Kinman, T. Kasumov, K.A. Jobbins, K.R. Thomas, J.E. Adams, L.N. Brunengraber, G. Kutz, W.-U. Brewer, C.R. Roe, H. Brunengraber, Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats, American Journal of Physiology, Endocrinology and Metabolism. 291 (2006) E860–E868.","bjps":"<b>Kinman RP <i>et al.</i></b> (2006) Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. <i>American journal of physiology, Endocrinology and metabolism</i> <b>291</b>, E860–E868.","mla":"Kinman, Renèe P., et al. “Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats.” <i>American Journal of Physiology, Endocrinology and Metabolism</i>, vol. 291, no. 4, 2006, pp. E860–68, <a href=\"https://doi.org/10.1152/ajpendo.00366.2005\">https://doi.org/10.1152/ajpendo.00366.2005</a>.","short":"R.P. Kinman, T. Kasumov, K.A. Jobbins, K.R. Thomas, J.E. Adams, L.N. Brunengraber, G. Kutz, W.-U. Brewer, C.R. Roe, H. Brunengraber, American Journal of Physiology, Endocrinology and Metabolism 291 (2006) E860–E868.","din1505-2-1":"<span style=\"font-variant:small-caps;\"><span style=\"font-variant:small-caps;\">Kinman, Renèe P.</span> ; <span style=\"font-variant:small-caps;\">Kasumov, Takhar</span> ; <span style=\"font-variant:small-caps;\">Jobbins, Kathryn A.</span> ; <span style=\"font-variant:small-caps;\">Thomas, Katherine R.</span> ; <span style=\"font-variant:small-caps;\">Adams, Jillian E.</span> ; <span style=\"font-variant:small-caps;\">Brunengraber, Lisa N.</span> ; <span style=\"font-variant:small-caps;\">Kutz, Gerd</span> ; <span style=\"font-variant:small-caps;\">Brewer, Wolf-Ulrich </span> ; u. a.</span>: Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. In: <i>American journal of physiology, Endocrinology and metabolism</i> Bd. 291, APS (2006), Nr. 4, S. E860–E868","chicago-de":"Kinman, Renèe P., Takhar Kasumov, Kathryn A. Jobbins, Katherine R. Thomas, Jillian E. Adams, Lisa N. Brunengraber, Gerd Kutz, Wolf-Ulrich  Brewer, Charles R. Roe und Henri  Brunengraber. 2006. Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. <i>American journal of physiology, Endocrinology and metabolism</i> 291, Nr. 4: E860–E868. doi:<a href=\"https://doi.org/10.1152/ajpendo.00366.2005\">https://doi.org/10.1152/ajpendo.00366.2005</a>, ."},"title":"Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats","status":"public","pmid":"1","page":"E860 - E868","external_id":{"pmid":["16705058"]},"author":[{"first_name":"Renèe P.","full_name":"Kinman, Renèe P.","last_name":"Kinman"},{"full_name":"Kasumov, Takhar","first_name":"Takhar","last_name":"Kasumov"},{"last_name":"Jobbins","first_name":"Kathryn A.","full_name":"Jobbins, Kathryn A."},{"full_name":"Thomas, Katherine R.","first_name":"Katherine R.","last_name":"Thomas"},{"first_name":"Jillian E.","full_name":"Adams, Jillian E.","last_name":"Adams"},{"full_name":"Brunengraber, Lisa N.","first_name":"Lisa N.","last_name":"Brunengraber"},{"full_name":"Kutz, Gerd","first_name":"Gerd","id":"12015","last_name":"Kutz"},{"last_name":"Brewer","first_name":"Wolf-Ulrich ","full_name":"Brewer, Wolf-Ulrich "},{"last_name":"Roe","full_name":"Roe, Charles R.","first_name":"Charles R."},{"last_name":"Brunengraber","first_name":"Henri ","full_name":"Brunengraber, Henri "}],"year":"2006","date_updated":"2024-11-15T15:04:06Z","publication":"American journal of physiology, Endocrinology and metabolism","date_created":"2020-06-02T08:19:56Z","language":[{"iso":"eng"}]},{"date_created":"2024-11-26T13:22:07Z","type":"conference_speech","date_updated":"2024-11-26T13:23:18Z","user_id":"83781","_id":"12068","language":[{"iso":"eng"}],"title":"A new manufacturing process for ISDN retard pellets: feasibility studies and risk assessment","publication_status":"published","citation":{"ama":"Bruns C, Kutz G, Wilms J. <i>A New Manufacturing Process for ISDN Retard Pellets: Feasibility Studies and Risk Assessment</i>.; 2005.","ieee":"C. Bruns, G. Kutz, and J. Wilms, <i>A new manufacturing process for ISDN retard pellets: feasibility studies and risk assessment</i>. 2005.","bjps":"<b>Bruns C, Kutz G and Wilms J</b> (2005) <i>A New Manufacturing Process for ISDN Retard Pellets: Feasibility Studies and Risk Assessment</i>. .","havard":"C. Bruns, G. Kutz, J. Wilms, A new manufacturing process for ISDN retard pellets: feasibility studies and risk assessment, 2005.","mla":"Bruns, Christina, et al. <i>A New Manufacturing Process for ISDN Retard Pellets: Feasibility Studies and Risk Assessment</i>. 2005.","ufg":"<b>Bruns, Christina/Kutz, Gerd/Wilms, J.</b>: A new manufacturing process for ISDN retard pellets: feasibility studies and risk assessment, o. O. 2005.","van":"Bruns C, Kutz G, Wilms J. A new manufacturing process for ISDN retard pellets: feasibility studies and risk assessment. 2005.","chicago":"Bruns, Christina, Gerd Kutz, and J. Wilms. <i>A New Manufacturing Process for ISDN Retard Pellets: Feasibility Studies and Risk Assessment</i>, 2005.","apa":"Bruns, C., Kutz, G., &#38; Wilms, J. (2005). <i>A new manufacturing process for ISDN retard pellets: feasibility studies and risk assessment</i>. 1st European Congress on Life Science Process Technology, Nürnberg.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Bruns, Christina</span> ; <span style=\"font-variant:small-caps;\">Kutz, Gerd</span> ; <span style=\"font-variant:small-caps;\">Wilms, J.</span>: <i>A new manufacturing process for ISDN retard pellets: feasibility studies and risk assessment</i>, 2005","chicago-de":"Bruns, Christina, Gerd Kutz und J. Wilms. 2005. <i>A new manufacturing process for ISDN retard pellets: feasibility studies and risk assessment</i>.","short":"C. Bruns, G. Kutz, J. Wilms, A New Manufacturing Process for ISDN Retard Pellets: Feasibility Studies and Risk Assessment, 2005."},"department":[{"_id":"DEP4022"}],"conference":{"name":"1st European Congress on Life Science Process Technology","location":"Nürnberg","start_date":"2005-10-11","end_date":"2005-10-13"},"main_file_link":[{"url":"https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://www.th-owl.de/fb4/fileadmin/download/06-Pharmatechnik/Kutz/48small.pdf&ved=2ahUKEwiSpN2CivqJAxXT87sIHS36FCwQFnoECBwQAQ&usg=AOvVaw1gxS7JZrebX4gKtTfEPxHo"}],"author":[{"id":"72986","first_name":"Christina","last_name":"Bruns","full_name":"Bruns, Christina"},{"id":"12015","last_name":"Kutz","full_name":"Kutz, Gerd","first_name":"Gerd"},{"full_name":"Wilms, J.","first_name":"J.","last_name":"Wilms"}],"year":"2005","status":"public"},{"title":"Quality and economic efficiency of inspection methods","citation":{"chicago-de":"Kardel, M., Gerd Kutz, R.  Rosito und H.  von Zydowitz. 2005. <i>Quality and economic efficiency of inspection methods</i>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kardel, M.</span> ; <span style=\"font-variant:small-caps;\">Kutz, Gerd</span> ; <span style=\"font-variant:small-caps;\">Rosito, R. </span> ; <span style=\"font-variant:small-caps;\">von Zydowitz, H. </span>: <i>Quality and economic efficiency of inspection methods</i>, 2005","short":"M. Kardel, G. Kutz, R. Rosito, H. von Zydowitz, Quality and Economic Efficiency of Inspection Methods, 2005.","bjps":"<b>Kardel M <i>et al.</i></b> (2005) <i>Quality and Economic Efficiency of Inspection Methods</i>. .","mla":"Kardel, M., et al. <i>Quality and Economic Efficiency of Inspection Methods</i>. 2005.","havard":"M. Kardel, G. Kutz, R. Rosito, H. von Zydowitz, Quality and economic efficiency of inspection methods, 2005.","ufg":"<b>Kardel, M. u. a.</b>: Quality and economic efficiency of inspection methods, o. O. 2005.","van":"Kardel M, Kutz G, Rosito R, von Zydowitz H. Quality and economic efficiency of inspection methods. 2005.","chicago":"Kardel, M., Gerd Kutz, R.  Rosito, and H.  von Zydowitz. <i>Quality and Economic Efficiency of Inspection Methods</i>, 2005.","apa":"Kardel, M., Kutz, G., Rosito, R., &#38; von Zydowitz, H. (2005). <i>Quality and economic efficiency of inspection methods</i>. 1st European Congress on Life Science Process Technology, Nürnberg.","ama":"Kardel M, Kutz G, Rosito R, von Zydowitz H. <i>Quality and Economic Efficiency of Inspection Methods</i>.; 2005.","ieee":"M. Kardel, G. Kutz, R. Rosito, and H. von Zydowitz, <i>Quality and economic efficiency of inspection methods</i>. 2005."},"department":[{"_id":"DEP4022"}],"conference":{"end_date":"2005-10-13","start_date":"2005-10-11","name":"1st European Congress on Life Science Process Technology","location":"Nürnberg"},"author":[{"last_name":"Kardel","first_name":"M.","full_name":"Kardel, M."},{"last_name":"Kutz","first_name":"Gerd","id":"12015","full_name":"Kutz, Gerd"},{"first_name":"R. ","full_name":"Rosito, R. ","last_name":"Rosito"},{"full_name":"von Zydowitz, H. ","first_name":"H. 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Kutz, V. Salzmann, C. Bruns, and S. Henning, “Feasibility studies on emulsion manufacturing using the Co-Twister processing facility,” presented at the 1st European Congress on Life Science Process Technology, Nürnberg, 2005.","apa":"Kutz, G., Salzmann, V., Bruns, C., &#38; Henning, S. (2005). <i>Feasibility studies on emulsion manufacturing using the Co-Twister processing facility</i>. 1st European Congress on Life Science Process Technology, Nürnberg.","chicago":"Kutz, Gerd, Volker Salzmann, Christina Bruns, and S. Henning. “Feasibility Studies on Emulsion Manufacturing Using the Co-Twister Processing Facility,” 2005.","ama":"Kutz G, Salzmann V, Bruns C, Henning S. Feasibility studies on emulsion manufacturing using the Co-Twister processing facility. In: ; 2005.","van":"Kutz G, Salzmann V, Bruns C, Henning S. Feasibility studies on emulsion manufacturing using the Co-Twister processing facility. In 2005.","havard":"G. Kutz, V. Salzmann, C. Bruns, S. 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Parfüm- und Kosmetika-Industrie </i> Bd. 77, Hüthig  (1997), Nr. 11, S. 700–703"},"publication_status":"published"},{"date_created":"2020-05-29T08:48:48Z","type":"journal_article","publication":"SÖFW-Journal : internationales Journal für angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte","date_updated":"2024-12-02T14:16:57Z","user_id":"83781","intvolume":"       123","language":[{"iso":"eng"}],"_id":"2707","title":"Zur Auswahl von O/W-Emulgatoren fur den Einsatz in Hautpflegeprodukten bei sensibler Haut : Teilergebnisse aus »Charakterisierung hautfreundlicher O/W-Emulgatoren«, P. Biehl, Diplomarbeit Lemgo 1995","publication_status":"published","citation":{"van":"Kutz G, Biehl P, Waldmann-Laue M, Jackwerth B. Zur Auswahl von O/W-Emulgatoren fur den Einsatz in Hautpflegeprodukten bei sensibler Haut : Teilergebnisse aus »Charakterisierung hautfreundlicher O/W-Emulgatoren«, P. Biehl, Diplomarbeit Lemgo 1995. 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Biehl, Diplomarbeit Lemgo 1995, in: <i>SÖFW-Journal : internationales Journal für angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte</i> 123 (1997), H. 3,  S. 145–150.","apa":"Kutz, G., Biehl, P., Waldmann-Laue, M., &#38; Jackwerth, B. (1997). Zur Auswahl von O/W-Emulgatoren fur den Einsatz in Hautpflegeprodukten bei sensibler Haut : Teilergebnisse aus »Charakterisierung hautfreundlicher O/W-Emulgatoren«, P. Biehl, Diplomarbeit Lemgo 1995. <i>SÖFW-Journal : Internationales Journal Für Angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte</i>, <i>123</i>(3), 145–150.","chicago":"Kutz, Gerd, P. Biehl, M. Waldmann-Laue, and B. Jackwerth. “Zur Auswahl von O/W-Emulgatoren Fur Den Einsatz in Hautpflegeprodukten Bei Sensibler Haut : Teilergebnisse Aus »Charakterisierung Hautfreundlicher O/W-Emulgatoren«, P. Biehl, Diplomarbeit Lemgo 1995.” <i>SÖFW-Journal : Internationales Journal Für Angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte</i> 123, no. 3 (1997): 145–50.","short":"G. Kutz, P. Biehl, M. Waldmann-Laue, B. Jackwerth, SÖFW-Journal : Internationales Journal Für Angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte 123 (1997) 145–150.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kutz, Gerd</span> ; <span style=\"font-variant:small-caps;\">Biehl, P.</span> ; <span style=\"font-variant:small-caps;\">Waldmann-Laue, M.</span> ; <span style=\"font-variant:small-caps;\">Jackwerth, B.</span>: Zur Auswahl von O/W-Emulgatoren fur den Einsatz in Hautpflegeprodukten bei sensibler Haut : Teilergebnisse aus »Charakterisierung hautfreundlicher O/W-Emulgatoren«, P. Biehl, Diplomarbeit Lemgo 1995. In: <i>SÖFW-Journal : internationales Journal für angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte</i> Bd. 123, Verl. für Chemische Industrie, Ziolkowsky (1997), Nr. 3, S. 145–150","chicago-de":"Kutz, Gerd, P. Biehl, M. Waldmann-Laue und B. Jackwerth. 1997. Zur Auswahl von O/W-Emulgatoren fur den Einsatz in Hautpflegeprodukten bei sensibler Haut : Teilergebnisse aus »Charakterisierung hautfreundlicher O/W-Emulgatoren«, P. Biehl, Diplomarbeit Lemgo 1995. <i>SÖFW-Journal : internationales Journal für angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte</i> 123, Nr. 3: 145–150.","ama":"Kutz G, Biehl P, Waldmann-Laue M, Jackwerth B. Zur Auswahl von O/W-Emulgatoren fur den Einsatz in Hautpflegeprodukten bei sensibler Haut : Teilergebnisse aus »Charakterisierung hautfreundlicher O/W-Emulgatoren«, P. Biehl, Diplomarbeit Lemgo 1995. <i>SÖFW-Journal : internationales Journal für angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte</i>. 1997;123(3):145-150.","ieee":"G. Kutz, P. Biehl, M. Waldmann-Laue, and B. Jackwerth, “Zur Auswahl von O/W-Emulgatoren fur den Einsatz in Hautpflegeprodukten bei sensibler Haut : Teilergebnisse aus »Charakterisierung hautfreundlicher O/W-Emulgatoren«, P. Biehl, Diplomarbeit Lemgo 1995,” <i>SÖFW-Journal : internationales Journal für angewandte Wissenschaft ; Kosmetik, Haushalt, Spezialprodukte</i>, vol. 123, no. 3, pp. 145–150, 1997."},"volume":123,"department":[{"_id":"DEP4022"}],"year":"1997","author":[{"full_name":"Kutz, Gerd","id":"12015","last_name":"Kutz","first_name":"Gerd"},{"full_name":"Biehl, P.","last_name":"Biehl","first_name":"P."},{"last_name":"Waldmann-Laue","first_name":"M.","full_name":"Waldmann-Laue, M."},{"full_name":"Jackwerth, B.","last_name":"Jackwerth","first_name":"B."}],"issue":"3","page":"145-150","status":"public","publisher":"Verl. für Chemische Industrie, Ziolkowsky"},{"title":"Neue Entwicklungen an der Fachhochschule Lippe","citation":{"ieee":"G. Kutz, <i>Neue Entwicklungen an der Fachhochschule Lippe</i>. 1996.","ama":"Kutz G. <i>Neue Entwicklungen an der Fachhochschule Lippe</i>.; 1996.","chicago":"Kutz, Gerd. <i>Neue Entwicklungen an der Fachhochschule Lippe</i>, 1996.","apa":"Kutz, G. 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