@misc{5504,
  author       = {{Katsch, Linda and Schneider, Jan}},
  booktitle    = {{Brauwelt}},
  issn         = {{1439-5177}},
  number       = {{14}},
  pages        = {{340--343}},
  publisher    = {{Fachverlag Hans Carl GmbH}},
  title        = {{{Potential für eine schonendere Pasteurisation}}},
  year         = {{2021}},
}

@misc{12805,
  abstract     = {{n recent decades, the demand for palm oil has constantly increased and with it the cultivation of oil palms. After a period of 25 years, the oil yield of the palm trees decreases and they are felled. The trees are cut into pieces and remain on the plantations. However, due to their high moisture and sugar content, fungi and molds cause problems for replanting. The use of the wood for the timber industry is difficult due to its structural characteristics. Biotechnological processes use microorganisms to produce relevant industrial products. The basis for each process is a culture medium that contains all necessary nutrients, especially carbohydrates. The culture medium makes up a high percentage of the costs, so alternative, cheaper substrates are preferred. In this review, we show and compare different analyses of the sap mechanically pressed from the oil palm trunk regarding its sugar and nutrient content. The total sugar concentration in the palm sap varies between 16.97–140 g L<jats:sup>−1</jats:sup> and it is mainly composed of glucose, fructose, and sucrose. The comparison with common nutrient media and the results of fermentation processes already carried out on a laboratory scale show that palm sap offers great potential as a fermentation medium for biotechnological conversion into industrially relevant products. }},
  author       = {{Dirkes, Rabea and Neubauer, Pia Rebecca and Rabenhorst, Jürgen}},
  booktitle    = {{Biofuels, Bioproducts and Biorefining}},
  issn         = {{1932-1031}},
  keywords     = {{oil palm, trunks, pressed sap, Elaeis guineensis, sugar, nutrients, review}},
  number       = {{3}},
  pages        = {{931--944}},
  publisher    = {{Wiley}},
  title        = {{{Pressed sap from oil palm (<scp><i>Elaeis guineensis</i></scp>) trunks: a revolutionary growth medium for the biotechnological industry?}}},
  doi          = {{10.1002/bbb.2201}},
  volume       = {{15}},
  year         = {{2021}},
}

@misc{12835,
  abstract     = {{Delayed-release dosage forms are mainly manufactured as batch processes and include coated tablets, pellets, or particles with gastric resistant polymers. Authors propose a novel approach using the hot-melt extrusion technique to prepare delayed release dosage forms via a continuous manufacturing process, a new trend in the pharmaceutical industry. A full factorial design was employed to correlate input variables, including stearic acid (SA) content, drug content, and pellet size with drug release properties of the pellets. PLS fit method suitably elaborated the relationship between input and output variables with reasonably good fit and goodness of prediction. All three input factors influenced drug release in enzyme-free simulated gastric fluid (SGF) after 120 min; however, SA content did not significantly affect drug dissolution in the enzyme-free simulated intestinal fluid (SIF). An optimized formulation and design space were determined by overlaying multiple contours established from regression equations. The continuous manufacturing process was successfully monitored using inline near-infrared (NIR) and inline particle size analysis, with drug load and pellet size being well-controlled within the design space. The obtained pellets released less than 5% after 120 min in SGF and more than 85% and 95% after 30 min and 45 min, respectively, after switching to SIF. (C) 2020 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.}},
  author       = {{Vo, Anh Q. and Kutz, Gerd and He, Herman and Narala, Sagar and Bandari, Suresh and Repka, Michael A.}},
  booktitle    = {{Journal of Pharmaceutical Sciences}},
  issn         = {{1520-6017}},
  keywords     = {{Continuous manufacturing, Delayed-release, FT-NIR, Inline particle size analysis, Hot melt extrusion}},
  number       = {{12}},
  pages        = {{3598--3607}},
  publisher    = {{Elsevier BV}},
  title        = {{{Continuous Manufacturing of Ketoprofen Delayed Release Pellets Using Melt Extrusion Technology: Application of QbD Design Space, Inline Near Infrared, and Inline Pellet Size Analysis}}},
  doi          = {{10.1016/j.xphs.2020.09.007}},
  volume       = {{109}},
  year         = {{2020}},
}