---
_id: '2630'
abstract:
- lang: eng
  text: 'The anaplerotic odd-medium-chain triglyceride triheptanoin is used in clinical
    trials for the chronic dietary treatment of patients with long-chain fatty acid
    oxidation disorders. We previously showed (Kinman RP, Kasumov T, Jobbins KA, Thomas
    KR, Adams JE, Brunengraber LN, Kutz G, Brewer WU, Roe CR, Brunengraber H. Am J
    Physiol Endocrinol Metab 291: E860–E866, 2006) that the intravenous infusion of
    triheptanoin increases lipolysis traced by the turnover of glycerol. In this study,
    we tested whether lipolysis induced by triheptanoin infusion is accompanied by
    the potentially harmful release of long-chain fatty acids. Rats were infused with
    heptanoate ± glycerol or triheptanoin. Intravenous infusion of triheptanoin at
    40% of caloric requirement markedly increased glycerol endogenous Ra but not oleate
    endogenous Ra. Thus, the activation of lipolysis was balanced by fatty acid reesterification
    in the same cells. The liver acyl-CoA profile showed the accumulation of intermediates
    of heptanoate β-oxidation and C5-ketogenesis and a decrease in free CoA but no
    evidence of metabolic perturbation of liver metabolism such as propionyl overload.
    Our data suggest that triheptanoin, administered either intravenously or intraduodenally,
    could be used for intensive care and nutritional support of metabolically decompensated
    long-chain fatty acid oxidation disorders.'
author:
- first_name: Lei
  full_name: Gu, Lei
  last_name: Gu
- first_name: Guo-Fang
  full_name: Zhang, Guo-Fang
  last_name: Zhang
- first_name: 'Rajan S. '
  full_name: ' Kombu, Rajan S. '
  last_name: ' Kombu'
- first_name: Frederick
  full_name: Allen, Frederick
  last_name: Allen
- first_name: Gerd
  full_name: Kutz, Gerd
  id: '12015'
  last_name: Kutz
- first_name: Brewer
  full_name: Brewer, Brewer
  last_name: Brewer
- first_name: Charles R.
  full_name: Roe, Charles R.
  last_name: Roe
- first_name: Henri
  full_name: Brunengraber, Henri
  last_name: Brunengraber
citation:
  ama: 'Gu L, Zhang GF,  Kombu RS, et al. Parenteral and Enteral Metabolism of Anaplerotic
    Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and
    liver acyl-CoA profile. <i>American journal of physiology : Endocrinology and
    metabolism</i>. 2010;298(2):E362-E371. doi:<a href="https://doi.org/10.1152/ajpendo.00384.2009">https://doi.org/10.1152/ajpendo.00384.2009</a>'
  apa: 'Gu, L., Zhang, G.-F.,  Kombu, R. S., Allen, F., Kutz, G., Brewer, B., Roe,
    C. R., &#38; Brunengraber, H. (2010). Parenteral and Enteral Metabolism of Anaplerotic
    Triheptanoin in Normal Rats. II. Effects on lipolysis, glucose production and
    liver acyl-CoA profile. <i>American Journal of Physiology : Endocrinology and
    Metabolism</i>, <i>298</i>(2), E362–E371. <a href="https://doi.org/10.1152/ajpendo.00384.2009">https://doi.org/10.1152/ajpendo.00384.2009</a>'
  bjps: '<b>Gu L <i>et al.</i></b> (2010) Parenteral and Enteral Metabolism of Anaplerotic
    Triheptanoin in Normal Rats. II. Effects on Lipolysis, Glucose Production and
    Liver Acyl-CoA Profile. <i>American journal of physiology : Endocrinology and
    metabolism</i> <b>298</b>, E362–E371.'
  chicago: 'Gu, Lei, Guo-Fang Zhang, Rajan S.   Kombu, Frederick Allen, Gerd Kutz,
    Brewer Brewer, Charles R. Roe, and Henri Brunengraber. “Parenteral and Enteral
    Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on Lipolysis,
    Glucose Production and Liver Acyl-CoA Profile.” <i>American Journal of Physiology :
    Endocrinology and Metabolism</i> 298, no. 2 (2010): E362–71. <a href="https://doi.org/10.1152/ajpendo.00384.2009">https://doi.org/10.1152/ajpendo.00384.2009</a>.'
  chicago-de: 'Gu, Lei, Guo-Fang Zhang, Rajan S.   Kombu, Frederick Allen, Gerd Kutz,
    Brewer Brewer, Charles R. Roe und Henri Brunengraber. 2010. Parenteral and Enteral
    Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on lipolysis,
    glucose production and liver acyl-CoA profile. <i>American journal of physiology :
    Endocrinology and metabolism</i> 298, Nr. 2: E362–E371. doi:<a href="https://doi.org/10.1152/ajpendo.00384.2009">https://doi.org/10.1152/ajpendo.00384.2009</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Gu, Lei</span> ; <span style="font-variant:small-caps;">Zhang,
    Guo-Fang</span> ; <span style="font-variant:small-caps;"> Kombu, Rajan S. </span>
    ; <span style="font-variant:small-caps;">Allen, Frederick</span> ; <span style="font-variant:small-caps;">Kutz,
    Gerd</span> ; <span style="font-variant:small-caps;">Brewer, Brewer</span> ; <span
    style="font-variant:small-caps;">Roe, Charles R.</span> ; <span style="font-variant:small-caps;">Brunengraber,
    Henri</span>: Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in
    Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA profile.
    In: <i>American journal of physiology : Endocrinology and metabolism</i> Bd. 298,
    APS (2010), Nr. 2, S. E362–E371'
  havard: 'L. Gu, G.-F. Zhang, R.S.  Kombu, F. Allen, G. Kutz, B. Brewer, C.R. Roe,
    H. Brunengraber, Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin
    in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA
    profile, American Journal of Physiology : Endocrinology and Metabolism. 298 (2010)
    E362–E371.'
  ieee: 'L. Gu <i>et al.</i>, “Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin
    in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA
    profile,” <i>American journal of physiology : Endocrinology and metabolism</i>,
    vol. 298, no. 2, pp. E362–E371, 2010, doi: <a href="https://doi.org/10.1152/ajpendo.00384.2009">https://doi.org/10.1152/ajpendo.00384.2009</a>.'
  mla: 'Gu, Lei, et al. “Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin
    in Normal Rats. II. Effects on Lipolysis, Glucose Production and Liver Acyl-CoA
    Profile.” <i>American Journal of Physiology : Endocrinology and Metabolism</i>,
    vol. 298, no. 2, 2010, pp. E362–71, <a href="https://doi.org/10.1152/ajpendo.00384.2009">https://doi.org/10.1152/ajpendo.00384.2009</a>.'
  short: 'L. Gu, G.-F. Zhang, R.S.  Kombu, F. Allen, G. Kutz, B. Brewer, C.R. Roe,
    H. Brunengraber, American Journal of Physiology : Endocrinology and Metabolism
    298 (2010) E362–E371.'
  ufg: '<b>Gu, Lei u. a.</b>: Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin
    in Normal Rats. II. Effects on lipolysis, glucose production and liver acyl-CoA
    profile, in: <i>American journal of physiology : Endocrinology and metabolism</i>
    298 (2010), H. 2,  S. E362–E371.'
  van: 'Gu L, Zhang GF,  Kombu RS, Allen F, Kutz G, Brewer B, et al. Parenteral and
    Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats. II. Effects on
    lipolysis, glucose production and liver acyl-CoA profile. American journal of
    physiology : Endocrinology and metabolism. 2010;298(2):E362–71.'
date_created: 2020-05-27T08:15:20Z
date_updated: 2024-11-26T08:25:38Z
department:
- _id: DEP4022
doi: https://doi.org/10.1152/ajpendo.00384.2009
external_id:
  pmid:
  - '19903863'
intvolume: '       298'
issue: '2'
language:
- iso: eng
page: E362 - E371
pmid: '1'
publication: 'American journal of physiology : Endocrinology and metabolism'
publication_identifier:
  eissn:
  - 1522-1555
  issn:
  - 0193-1849
publication_status: published
publisher: APS
quality_controlled: '1'
status: public
title: Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats.
  II. Effects on lipolysis, glucose production and liver acyl-CoA profile
type: journal_article
user_id: '83781'
volume: 298
year: '2010'
...