[{"doi":"10.1002/cite.70048","volume":98,"user_id":"45666","quality_controlled":"1","type":"scientific_journal_article","date_updated":"2026-03-27T17:14:42Z","intvolume":"        98","date_created":"2025-12-08T07:26:52Z","issue":"1-2","abstract":[{"text":"Determining cell density and viability with (semi‐)automated methods enables rapid cell cultivation analysis. However, scientific validation is required, typically by comparing results to manual counting. To address this, we present a method to evaluate and compare two cell counting methods exemplified by a manual and a semi‐automated method (Countstar BioTech). Experiments followed validation parameters aligned with the International Council for Harmonization (ICH) Q2(R1) guideline and a dilution series design based on ISO 20391‐2:2019. Both the semi‐automated and manual methods showed comparable specificity and linearity for Chinese hamster ovary (CHO)‐K1 cells. The semi‐automated method exhibited superior repeatability for total cell density, whereas cell viability results showed no significant difference.","lang":"eng"}],"publisher":"Wiley","author":[{"orcid":"https://orcid.org/0000-0002-0502-8032","full_name":"Uhlendorff, Selina","id":"68713","first_name":"Selina","last_name":"Uhlendorff"},{"last_name":"Odefey","first_name":"Ulrich","id":"74218","full_name":"Odefey, Ulrich"},{"last_name":"Frahm","first_name":"Björn","id":"45666","full_name":"Frahm, Björn"},{"orcid":"0000-0002-7920-0595","full_name":"Pein-Hackelbusch, Miriam","last_name":"Pein-Hackelbusch","id":"64952","first_name":"Miriam"}],"title":"Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture","department":[{"_id":"DEP4029"},{"_id":"DEP4028"}],"language":[{"iso":"eng"}],"year":"2025","publication":"Chemie Ingenieur Technik","keyword":["Cell density","Cell enumeration","Cell viability","CHO-K1"],"_id":"13315","publication_identifier":{"eissn":["1522-2640"],"issn":["0009-286X"]},"page":"57–68","oa":"1","citation":{"ama":"Uhlendorff S, Odefey U, Frahm B, Pein-Hackelbusch M. Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. <i>Chemie Ingenieur Technik</i>. 2025;98(1-2):57-68. doi:<a href=\"https://doi.org/10.1002/cite.70048\">10.1002/cite.70048</a>","ufg":"<b>Uhlendorff, Selina u. a.</b>: Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture, in: <i>Chemie Ingenieur Technik</i> 98 (2025), H. 1–2,  S. 57–68.","chicago-de":"Uhlendorff, Selina, Ulrich Odefey, Björn Frahm und Miriam Pein-Hackelbusch. 2025. Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. <i>Chemie Ingenieur Technik</i> 98, Nr. 1–2: 57–68. doi:<a href=\"https://doi.org/10.1002/cite.70048\">10.1002/cite.70048</a>, .","chicago":"Uhlendorff, Selina, Ulrich Odefey, Björn Frahm, and Miriam Pein-Hackelbusch. “Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture.” <i>Chemie Ingenieur Technik</i> 98, no. 1–2 (2025): 57–68. <a href=\"https://doi.org/10.1002/cite.70048\">https://doi.org/10.1002/cite.70048</a>.","ieee":"S. Uhlendorff, U. Odefey, B. Frahm, and M. Pein-Hackelbusch, “Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture,” <i>Chemie Ingenieur Technik</i>, vol. 98, no. 1–2, pp. 57–68, 2025, doi: <a href=\"https://doi.org/10.1002/cite.70048\">10.1002/cite.70048</a>.","bjps":"<b>Uhlendorff S <i>et al.</i></b> (2025) Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. <i>Chemie Ingenieur Technik</i> <b>98</b>, 57–68.","havard":"S. Uhlendorff, U. Odefey, B. Frahm, M. Pein-Hackelbusch, Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture, Chemie Ingenieur Technik. 98 (2025) 57–68.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Uhlendorff, Selina</span> ; <span style=\"font-variant:small-caps;\">Odefey, Ulrich</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span>: Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. In: <i>Chemie Ingenieur Technik</i> Bd. 98. Weinheim, Wiley (2025), Nr. 1–2, S. 57–68","apa":"Uhlendorff, S., Odefey, U., Frahm, B., &#38; Pein-Hackelbusch, M. (2025). Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. <i>Chemie Ingenieur Technik</i>, <i>98</i>(1–2), 57–68. <a href=\"https://doi.org/10.1002/cite.70048\">https://doi.org/10.1002/cite.70048</a>","mla":"Uhlendorff, Selina, et al. “Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture.” <i>Chemie Ingenieur Technik</i>, vol. 98, no. 1–2, 2025, pp. 57–68, <a href=\"https://doi.org/10.1002/cite.70048\">https://doi.org/10.1002/cite.70048</a>.","van":"Uhlendorff S, Odefey U, Frahm B, Pein-Hackelbusch M. Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. Chemie Ingenieur Technik. 2025;98(1–2):57–68.","short":"S. Uhlendorff, U. Odefey, B. Frahm, M. Pein-Hackelbusch, Chemie Ingenieur Technik 98 (2025) 57–68."},"place":"Weinheim","status":"public","main_file_link":[{"open_access":"1"}],"publication_status":"published"},{"intvolume":"        96","date_updated":"2025-06-25T12:42:09Z","type":"scientific_journal_article","quality_controlled":"1","user_id":"83781","doi":"10.1002/cite.202300188","volume":96,"publication":"Chemie Ingenieur Technik","year":"2024","language":[{"iso":"eng"}],"department":[{"_id":"DEP4000"}],"title":"Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator","author":[{"full_name":"Kosse, Pascal","last_name":"Kosse","first_name":"Pascal"},{"full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja","id":"52466","last_name":"Hernández Rodriguez"},{"last_name":"Frahm","first_name":"Björn","id":"45666","full_name":"Frahm, Björn"},{"first_name":"Manfred","last_name":"Lübken","full_name":"Lübken, Manfred"},{"last_name":"Wichern","first_name":"Marc","full_name":"Wichern, Marc"}],"abstract":[{"lang":"eng","text":"In anaerobic technology, pH values are crucial for targeted volatile fatty acid production. While pH dynamics can be modeled using the Anaerobic Digestion Model No. 1 (ADM1), simulation results may be biased. To address this issue, the pH prediction routine of Visual Water, a specialized water chemistry simulator, was validated. Unlike ADM1, it accounts for ionic strength and activities while also providing an automated uncertainty analysis. The analysis revealed Visual Water simulations to better fit measured pH data from acidic solutions in a miniaturized stirred-tank reactor."}],"publisher":"Wiley","date_created":"2025-01-29T13:49:16Z","issue":"4","publication_identifier":{"issn":["0009-286X"],"eissn":["1522-2640"]},"_id":"12402","keyword":["Anaerobic Digestion Model No. 1 (ADM1)","Anaerobic technology","pH simulation","Uncertainty assessment","Visual Water"],"publication_status":"published","isi":"1","external_id":{"isi":["001169606600001"]},"status":"public","place":"Weinheim","citation":{"bjps":"<b>Kosse P <i>et al.</i></b> (2024) Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. <i>Chemie Ingenieur Technik</i> <b>96</b>, 528–534.","ufg":"<b>Kosse, Pascal u. a.</b>: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, in: <i>Chemie Ingenieur Technik</i> 96 (2024), H. 4,  S. 528–534.","ieee":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, and M. Wichern, “Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator,” <i>Chemie Ingenieur Technik</i>, vol. 96, no. 4, pp. 528–534, 2024, doi: <a href=\"https://doi.org/10.1002/cite.202300188\">10.1002/cite.202300188</a>.","ama":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. <i>Chemie Ingenieur Technik</i>. 2024;96(4):528-534. doi:<a href=\"https://doi.org/10.1002/cite.202300188\">10.1002/cite.202300188</a>","short":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 96 (2024) 528–534.","chicago":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken, and Marc Wichern. “Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.” <i>Chemie Ingenieur Technik</i> 96, no. 4 (2024): 528–34. <a href=\"https://doi.org/10.1002/cite.202300188\">https://doi.org/10.1002/cite.202300188</a>.","apa":"Kosse, P., Hernández Rodriguez, T., Frahm, B., Lübken, M., &#38; Wichern, M. (2024). Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. <i>Chemie Ingenieur Technik</i>, <i>96</i>(4), 528–534. <a href=\"https://doi.org/10.1002/cite.202300188\">https://doi.org/10.1002/cite.202300188</a>","mla":"Kosse, Pascal, et al. “Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.” <i>Chemie Ingenieur Technik</i>, vol. 96, no. 4, 2024, pp. 528–34, <a href=\"https://doi.org/10.1002/cite.202300188\">https://doi.org/10.1002/cite.202300188</a>.","van":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik. 2024;96(4):528–34.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kosse, Pascal</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Lübken, Manfred</span> ; <span style=\"font-variant:small-caps;\">Wichern, Marc</span>: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. In: <i>Chemie Ingenieur Technik</i> Bd. 96. Weinheim, Wiley (2024), Nr. 4, S. 528–534","chicago-de":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken und Marc Wichern. 2024. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. <i>Chemie Ingenieur Technik</i> 96, Nr. 4: 528–534. doi:<a href=\"https://doi.org/10.1002/cite.202300188\">10.1002/cite.202300188</a>, .","havard":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, Chemie Ingenieur Technik. 96 (2024) 528–534."},"page":"528-534"},{"date_updated":"2025-06-26T07:50:29Z","intvolume":"        95","volume":95,"doi":"10.1002/cite.202300082","user_id":"83781","type":"scientific_journal_article","quality_controlled":"1","author":[{"full_name":"Kosse, Pascal","last_name":"Kosse","first_name":"Pascal"},{"full_name":"Hernández Rodriguez, Tanja","id":"52466","first_name":"Tanja","last_name":"Hernández Rodriguez"},{"full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn","id":"45666"},{"full_name":"Lübken, Manfred","first_name":"Manfred","last_name":"Lübken"},{"last_name":"Wichern","first_name":"Marc","full_name":"Wichern, Marc"}],"title":"Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations","language":[{"iso":"eng"}],"department":[{"_id":"DEP4000"}],"year":"2023","publication":"Chemie Ingenieur Technik","date_created":"2024-04-26T06:52:48Z","issue":"12","publisher":"Wiley","abstract":[{"lang":"eng","text":"Accurate pH calculations are essential for scientists across different disciplines to design optimal reactor solutions, but they can be arduous to calculate for complex acid-base solutions. Visual Water is a powerful software tool that provides accurate pH calculations with automated mathematical uncertainty analysis. Its workflow is presented and validated using acids and bases, showing a deviation of < 0.2 pH units between measured and calculated pH values. This highlights the software's reliability, which can help to simplify the work of non-experts in water chemistry."}],"publication_identifier":{"issn":["0009-286X"],"eissn":["1522-2640"]},"keyword":["Acid-base equilibria","Carboxylic acids","Dissociation constants","pH calculation software","Uncertainty assessment"],"_id":"11385","external_id":{"isi":["001073579300001"]},"isi":"1","publication_status":"published","citation":{"chicago":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken, and Marc Wichern. “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations.” <i>Chemie Ingenieur Technik</i> 95, no. 12 (2023): 1960–69. <a href=\"https://doi.org/10.1002/cite.202300082\">https://doi.org/10.1002/cite.202300082</a>.","chicago-de":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken und Marc Wichern. 2023. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. <i>Chemie Ingenieur Technik</i> 95, Nr. 12: 1960–1969. doi:<a href=\"https://doi.org/10.1002/cite.202300082\">10.1002/cite.202300082</a>, .","ama":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. <i>Chemie Ingenieur Technik</i>. 2023;95(12):1960-1969. doi:<a href=\"https://doi.org/10.1002/cite.202300082\">10.1002/cite.202300082</a>","ufg":"<b>Kosse, Pascal u. a.</b>: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, in: <i>Chemie Ingenieur Technik</i> 95 (2023), H. 12,  S. 1960–1969.","short":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 95 (2023) 1960–1969.","van":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik. 2023;95(12):1960–9.","apa":"Kosse, P., Hernández Rodriguez, T., Frahm, B., Lübken, M., &#38; Wichern, M. (2023). Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. <i>Chemie Ingenieur Technik</i>, <i>95</i>(12), 1960–1969. <a href=\"https://doi.org/10.1002/cite.202300082\">https://doi.org/10.1002/cite.202300082</a>","mla":"Kosse, Pascal, et al. “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations.” <i>Chemie Ingenieur Technik</i>, vol. 95, no. 12, 2023, pp. 1960–69, <a href=\"https://doi.org/10.1002/cite.202300082\">https://doi.org/10.1002/cite.202300082</a>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kosse, Pascal</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Lübken, Manfred</span> ; <span style=\"font-variant:small-caps;\">Wichern, Marc</span>: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. In: <i>Chemie Ingenieur Technik</i> Bd. 95. Weinheim, Wiley (2023), Nr. 12, S. 1960–1969","havard":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, Chemie Ingenieur Technik. 95 (2023) 1960–1969.","bjps":"<b>Kosse P <i>et al.</i></b> (2023) Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations. <i>Chemie Ingenieur Technik</i> <b>95</b>, 1960–1969.","ieee":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, and M. Wichern, “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations,” <i>Chemie Ingenieur Technik</i>, vol. 95, no. 12, pp. 1960–1969, 2023, doi: <a href=\"https://doi.org/10.1002/cite.202300082\">10.1002/cite.202300082</a>."},"page":"1960-1969","status":"public","place":"Weinheim"},{"doi":"10.1002/cite.200407094","volume":77,"_id":"2347","user_id":"45666","type":"scientific_journal_article","date_updated":"2023-03-15T13:49:39Z","extern":"1","publication_identifier":{"issn":["0009-286X"],"eissn":["1522-2640"]},"intvolume":"        77","page":"429-435","oa":"1","citation":{"chicago":"Frahm, Björn, Paul Lane, Axel Munack, and Ralf Pörtner. “Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode.” <i>Chemie Ingenieur Technik</i> 77, no. 4 (2005): 429–35. <a href=\"https://doi.org/10.1002/cite.200407094\">https://doi.org/10.1002/cite.200407094</a>.","mla":"Frahm, Björn, et al. “Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode.” <i>Chemie Ingenieur Technik</i>, vol. 77, no. 4, WILEY-VCH Verlag, 2005, pp. 429–35, doi:<a href=\"https://doi.org/10.1002/cite.200407094\">10.1002/cite.200407094</a>.","apa":"Frahm, B., Lane, P., Munack, A., &#38; Pörtner, R. (2005). Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. <i>Chemie Ingenieur Technik</i>, <i>77</i>(4), 429–435. <a href=\"https://doi.org/10.1002/cite.200407094\">https://doi.org/10.1002/cite.200407094</a>","van":"Frahm B, Lane P, Munack A, Pörtner R. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. Chemie Ingenieur Technik. 2005;77(4):429–35.","short":"B. Frahm, P. Lane, A. Munack, R. Pörtner, Chemie Ingenieur Technik 77 (2005) 429–435.","havard":"B. Frahm, P. Lane, A. Munack, R. Pörtner, Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode, Chemie Ingenieur Technik. 77 (2005) 429–435.","chicago-de":"Frahm, Björn, Paul Lane, Axel Munack und Ralf Pörtner. 2005. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. <i>Chemie Ingenieur Technik</i> 77, Nr. 4: 429–435. doi:<a href=\"https://doi.org/10.1002/cite.200407094,\">10.1002/cite.200407094,</a> .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Lane, Paul</span> ; <span style=\"font-variant:small-caps;\">Munack, Axel</span> ; <span style=\"font-variant:small-caps;\">Pörtner, Ralf</span>: Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. In: <i>Chemie Ingenieur Technik</i> Bd. 77, WILEY-VCH Verlag (2005), Nr. 4, S. 429–435","ufg":"<b>Frahm, Björn et. al. (2005)</b>: Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode, in: <i>Chemie Ingenieur Technik</i> <i>77</i> (<i>4</i>), S. 429–435.","ieee":"B. Frahm, P. Lane, A. Munack, and R. Pörtner, “Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode,” <i>Chemie Ingenieur Technik</i>, vol. 77, no. 4, pp. 429–435, 2005.","ama":"Frahm B, Lane P, Munack A, Pörtner R. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. <i>Chemie Ingenieur Technik</i>. 2005;77(4):429-435. doi:<a href=\"https://doi.org/10.1002/cite.200407094\">10.1002/cite.200407094</a>","bjps":"<b>Frahm B <i>et al.</i></b> (2005) Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. <i>Chemie Ingenieur Technik</i> <b>77</b>, 429–435."},"status":"public","issue":"4","date_created":"2020-05-15T10:06:16Z","publisher":"WILEY-VCH Verlag","author":[{"last_name":"Frahm","first_name":"Björn","id":"45666","full_name":"Frahm, Björn"},{"last_name":"Lane","first_name":"Paul","full_name":"Lane, Paul"},{"full_name":"Munack, Axel","last_name":"Munack","first_name":"Axel"},{"first_name":"Ralf","last_name":"Pörtner","full_name":"Pörtner, Ralf"}],"main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1002/cite.200407094","open_access":"1"}],"title":"Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode","language":[{"iso":"ger"}],"department":[{"_id":"DEP4021"}],"year":2005,"publication":"Chemie Ingenieur Technik","publication_status":"published"},{"page":"457-460","oa":"1","citation":{"bjps":"<b>Frahm B <i>et al.</i></b> (2003) Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. <i>Chemie Ingenieur Technik</i> <b>75</b>, 457–460.","ieee":"B. Frahm, V. C. Hass, P. Lane, A. Munack, H. Märkl, and R. Pörtner, “Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung,” <i>Chemie Ingenieur Technik</i>, vol. 75, no. 4, pp. 457–460, 2003.","short":"B. Frahm, V.C. Hass, P. Lane, A. Munack, H. Märkl, R. Pörtner, Chemie Ingenieur Technik 75 (2003) 457–460.","mla":"Frahm, Björn, et al. “Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung.” <i>Chemie Ingenieur Technik</i>, vol. 75, no. 4, WILEY-VCH Verlag, 2003, pp. 457–60, doi:<a href=\"https://doi.org/10.1002/cite.200390093\">10.1002/cite.200390093</a>.","van":"Frahm B, Hass VC, Lane P, Munack A, Märkl H, Pörtner R. Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. Chemie Ingenieur Technik. 2003;75(4):457–60.","apa":"Frahm, B., Hass, V. C., Lane, P., Munack, A., Märkl, H., &#38; Pörtner, R. (2003). Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. <i>Chemie Ingenieur Technik</i>, <i>75</i>(4), 457–460. <a href=\"https://doi.org/10.1002/cite.200390093\">https://doi.org/10.1002/cite.200390093</a>","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Hass, V. C.</span> ; <span style=\"font-variant:small-caps;\">Lane, P.</span> ; <span style=\"font-variant:small-caps;\">Munack, A.</span> ; <span style=\"font-variant:small-caps;\">Märkl, H.</span> ; <span style=\"font-variant:small-caps;\">Pörtner, R.</span>: Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. In: <i>Chemie Ingenieur Technik</i> Bd. 75, WILEY-VCH Verlag (2003), Nr. 4, S. 457–460","havard":"B. Frahm, V.C. Hass, P. Lane, A. Munack, H. Märkl, R. Pörtner, Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung, Chemie Ingenieur Technik. 75 (2003) 457–460.","ufg":"<b>Frahm, Björn et. al. (2003)</b>: Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung, in: <i>Chemie Ingenieur Technik</i> <i>75</i> (<i>4</i>), S. 457–460.","ama":"Frahm B, Hass VC, Lane P, Munack A, Märkl H, Pörtner R. Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. <i>Chemie Ingenieur Technik</i>. 2003;75(4):457-460. doi:<a href=\"https://doi.org/10.1002/cite.200390093\">10.1002/cite.200390093</a>","chicago":"Frahm, Björn, V. C. Hass, P. Lane, A. Munack, H. Märkl, and R. Pörtner. “Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung.” <i>Chemie Ingenieur Technik</i> 75, no. 4 (2003): 457–60. <a href=\"https://doi.org/10.1002/cite.200390093\">https://doi.org/10.1002/cite.200390093</a>.","chicago-de":"Frahm, Björn, V. C. Hass, P. Lane, A. Munack, H. Märkl und R. Pörtner. 2003. Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. <i>Chemie Ingenieur Technik</i> 75, Nr. 4: 457–460. doi:<a href=\"https://doi.org/10.1002/cite.200390093,\">10.1002/cite.200390093,</a> ."},"status":"public","main_file_link":[{"open_access":"1","url":"https://www.onlinelibrary.wiley.com/doi/10.1002/cite.200390093"}],"publication_status":"published","_id":"2343","publication_identifier":{"eissn":["1522-2640"],"issn":["0009-286X"]},"issue":"4","date_created":"2020-05-15T09:06:56Z","publisher":"WILEY-VCH Verlag","author":[{"full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn","id":"45666"},{"full_name":"Hass, V. C.","first_name":"V. C.","last_name":"Hass"},{"first_name":"P.","last_name":"Lane","full_name":"Lane, P."},{"full_name":"Munack, A.","first_name":"A.","last_name":"Munack"},{"full_name":"Märkl, H.","first_name":"H.","last_name":"Märkl"},{"first_name":"R.","last_name":"Pörtner","full_name":"Pörtner, R."}],"title":"Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung","department":[{"_id":"DEP4021"}],"language":[{"iso":"ger"}],"publication":"Chemie Ingenieur Technik","year":2003,"doi":"10.1002/cite.200390093","volume":75,"user_id":"45666","type":"scientific_journal_article","date_updated":"2023-03-15T13:49:39Z","extern":"1","intvolume":"        75"}]