---
_id: '2637'
abstract:
- lang: eng
  text: Anaplerotic TH (glycerol triheptanoate) is used for the chronic oral treatment
    of long-chain fatty acid oxidation disorders (FOD). To test whether TH could also
    be used for the acute intravenous treatment of decompensated FOD patients, we
    investigated the metabolism and metabolic effects of triheptanoin emulsion administered
    parenterally or enterally. Rats were infused with TH emulsion (intravenously or
    intragastrically). Stable isotope tracers were infused intravenously to measure
    the rates of appearance (Ra) of plasma glucose, glycerol and fatty acids. Surprisingly,
    intravenous infusion of triheptanoin markedly increased glycerol Ra but not oleate
    Ra. This indicated that massive lipolysis induced by intravenous TH was not accompanied
    by the release of long-chain fatty acids from adipocytes. This probably results
    from the contribution of anaplerotic propionyl-CoA moiety of heptanoate to glyceroneogenesis
    in adipocytes, generating sufficient amounts of glycerol-3-phosphate to re-esterify
    the fatty acids derived from stimulated lipolysis. The intraduodenal infusion
    of TH did not induce lipolysis because TH was hydrolyzed in the gut. Our data
    support the use of intravenous TH emulsion for the acute treatment of FOD patients
    (for whom the release of fatty acids from adipocytes would be harmful). Supported
    by NIH.
author:
- first_name: Lei
  full_name: Gu, Lei
  last_name: Gu
- first_name: Guofang
  full_name: Zhang, Guofang
  last_name: Zhang
- first_name: Rajan
  full_name: S. Kombu, Rajan
  last_name: S. Kombu
- first_name: Gerd
  full_name: Kutz, Gerd
  id: '12015'
  last_name: Kutz
- first_name: Wolf-Ulrich
  full_name: Brewer, Wolf-Ulrich
  last_name: Brewer
- first_name: Charles R.
  full_name: Roe, Charles R.
  last_name: Roe
- first_name: Henri
  full_name: Brunengraber, Henri
  last_name: Brunengraber
citation:
  ama: 'Gu L, Zhang G, S. Kombu R, et al. Metabolism and metabolic effects of anaplerotic
    triheptanoin (TH) in normal rats. <i>  The FASEB journal : the official journal
    of the Federation of American Societies for Experimental Biology</i>. 2009;23(4):506.3.
    doi:<a href="https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3">
    https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>'
  apa: 'Gu, L., Zhang, G., S. Kombu, R., Kutz, G., Brewer, W.-U., Roe, C. R., &#38;
    Brunengraber, H. (2009). Metabolism and metabolic effects of anaplerotic triheptanoin
    (TH) in normal rats. <i>  The FASEB Journal : The Official Journal of the Federation
    of American Societies for Experimental Biology</i>, <i>23</i>(4), 506.3. <a href="https://doi.org/
    https://doi.org/10.1096/fasebj.23.1_supplement.506.3">https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>'
  bjps: '<b>Gu L <i>et al.</i></b> (2009) Metabolism and Metabolic Effects of Anaplerotic
    Triheptanoin (TH) in Normal Rats. <i>  The FASEB journal : the official journal
    of the Federation of American Societies for Experimental Biology</i> <b>23</b>,
    506.3.'
  chicago: 'Gu, Lei, Guofang Zhang, Rajan S. Kombu, Gerd Kutz, Wolf-Ulrich Brewer,
    Charles R. Roe, and Henri Brunengraber. “Metabolism and Metabolic Effects of Anaplerotic
    Triheptanoin (TH) in Normal Rats.” <i>  The FASEB Journal : The Official Journal
    of the Federation of American Societies for Experimental Biology</i> 23, no. 4
    (2009): 506.3. <a href="https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3">https://doi.org/
    https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>.'
  chicago-de: 'Gu, Lei, Guofang Zhang, Rajan S. Kombu, Gerd Kutz, Wolf-Ulrich Brewer,
    Charles R. Roe und Henri Brunengraber. 2009. Metabolism and metabolic effects
    of anaplerotic triheptanoin (TH) in normal rats. <i>  The FASEB journal : the
    official journal of the Federation of American Societies for Experimental Biology</i>
    23, Nr. 4: 506.3. doi:<a href="https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3">
    https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>, .'
  din1505-2-1: '<span style="font-variant:small-caps;">Gu, Lei</span> ; <span style="font-variant:small-caps;">Zhang,
    Guofang</span> ; <span style="font-variant:small-caps;">S. Kombu, Rajan</span>
    ; <span style="font-variant:small-caps;">Kutz, Gerd</span> ; <span style="font-variant:small-caps;">Brewer,
    Wolf-Ulrich</span> ; <span style="font-variant:small-caps;">Roe, Charles R.</span>
    ; <span style="font-variant:small-caps;">Brunengraber, Henri</span>: Metabolism
    and metabolic effects of anaplerotic triheptanoin (TH) in normal rats. In: <i> 
    The FASEB journal : the official journal of the Federation of American Societies
    for Experimental Biology</i> Bd. 23, Wiley (2009), Nr. 4, S. 506.3'
  havard: 'L. Gu, G. Zhang, R. S. Kombu, G. Kutz, W.-U. Brewer, C.R. Roe, H. Brunengraber,
    Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal rats,
      The FASEB Journal : The Official Journal of the Federation of American Societies
    for Experimental Biology. 23 (2009) 506.3.'
  ieee: 'L. Gu <i>et al.</i>, “Metabolism and metabolic effects of anaplerotic triheptanoin
    (TH) in normal rats,” <i>  The FASEB journal : the official journal of the Federation
    of American Societies for Experimental Biology</i>, vol. 23, no. 4, p. 506.3,
    2009, doi: <a href="https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3">
    https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>.'
  mla: 'Gu, Lei, et al. “Metabolism and Metabolic Effects of Anaplerotic Triheptanoin
    (TH) in Normal Rats.” <i>  The FASEB Journal : The Official Journal of the Federation
    of American Societies for Experimental Biology</i>, vol. 23, no. 4, 2009, p. 506.3,
    <a href="https://doi.org/ https://doi.org/10.1096/fasebj.23.1_supplement.506.3">https://doi.org/
    https://doi.org/10.1096/fasebj.23.1_supplement.506.3</a>.'
  short: 'L. Gu, G. Zhang, R. S. Kombu, G. Kutz, W.-U. Brewer, C.R. Roe, H. Brunengraber,
      The FASEB Journal : The Official Journal of the Federation of American Societies
    for Experimental Biology 23 (2009) 506.3.'
  ufg: '<b>Gu, Lei u. a.</b>: Metabolism and metabolic effects of anaplerotic triheptanoin
    (TH) in normal rats, in: <i>  The FASEB journal : the official journal of the
    Federation of American Societies for Experimental Biology</i> 23 (2009), H. 4, 
    S. 506.3.'
  van: 'Gu L, Zhang G, S. Kombu R, Kutz G, Brewer WU, Roe CR, et al. Metabolism and
    metabolic effects of anaplerotic triheptanoin (TH) in normal rats.   The FASEB
    journal : the official journal of the Federation of American Societies for Experimental
    Biology. 2009;23(4):506.3.'
date_created: 2020-05-27T08:21:35Z
date_updated: 2024-11-19T10:22:09Z
department:
- _id: DEP4022
doi: ' https://doi.org/10.1096/fasebj.23.1_supplement.506.3'
intvolume: '        23'
issue: '4'
language:
- iso: eng
page: '506.3'
publication: '  The FASEB journal : the official journal of the Federation of American
  Societies for Experimental Biology'
publication_identifier:
  eissn:
  - 1530-6860
  issn:
  - '0892-6638 '
publication_status: published
publisher: Wiley
status: public
title: Metabolism and metabolic effects of anaplerotic triheptanoin (TH) in normal
  rats
type: journal_article
user_id: '83781'
volume: 23
year: '2009'
...