---
_id: '11732'
abstract:
- lang: eng
  text: "Abstract\r\nIntroduction: A required step for presenting results of clinical
    studies is the declaration of participants demographic and baseline characteristics
    as claimed by the FDAAA 801. The common workflow to accomplish this task is to
    export the clinical data from the used electronic data capture system and import
    it into statistical software like SAS software or IBM SPSS. This software requires
    trained users, who have to implement the analysis individually for each item.
    These expenditures may become an obstacle for small studies. Objective of this
    work is to design, implement and evaluate an open source application, called ODM
    Data Analysis, for the semi-automatic analysis of clinical study data.\r\n\r\nMethods:
    The system requires clinical data in the CDISC Operational Data Model format.
    After uploading the file, its syntax and data type conformity of the collected
    data is validated. The completeness of the study data is determined and basic
    statistics, including illustrative charts for each item, are generated. Datasets
    from four clinical studies have been used to evaluate the application's performance
    and functionality.\r\n\r\nResults: The system is implemented as an open source
    web application (available at https://odmanalysis.uni-muenster.de) and also provided
    as Docker image which enables an easy distribution and installation on local systems.
    Study data is only stored in the application as long as the calculations are performed
    which is compliant with data protection endeavors. Analysis times are below half
    an hour, even for larger studies with over 6000 subjects.\r\n\r\nDiscussion: Medical
    experts have ensured the usefulness of this application to grant an overview of
    their collected study data for monitoring purposes and to generate descriptive
    statistics without further user interaction. The semi-automatic analysis has its
    limitations and cannot replace the complex analysis of statisticians, but it can
    be used as a starting point for their examination and reporting."
article_number: e0199242
author:
- first_name: Tobias Johannes
  full_name: Brix, Tobias Johannes
  last_name: Brix
- first_name: Philipp
  full_name: Bruland, Philipp
  id: '75847'
  last_name: Bruland
  orcid: 0000-0001-6939-7630
- first_name: Saad
  full_name: Sarfraz, Saad
  last_name: Sarfraz
- first_name: Jan
  full_name: Ernsting, Jan
  last_name: Ernsting
- first_name: Philipp
  full_name: Neuhaus, Philipp
  last_name: Neuhaus
- first_name: Michael
  full_name: Storck, Michael
  last_name: Storck
- first_name: Justin
  full_name: Doods, Justin
  last_name: Doods
- first_name: Sonja
  full_name: Ständer, Sonja
  last_name: Ständer
- first_name: Martin
  full_name: Dugas, Martin
  last_name: Dugas
citation:
  ama: Brix TJ, Bruland P, Sarfraz S, et al. ODM Data Analysis—A tool for the automatic
    validation, monitoring and generation of generic descriptive statistics of patient
    data. <i>PLOS ONE</i>. 2018;13(6). doi:<a href="https://doi.org/10.1371/journal.pone.0199242">10.1371/journal.pone.0199242</a>
  apa: Brix, T. J., Bruland, P., Sarfraz, S., Ernsting, J., Neuhaus, P., Storck, M.,
    Doods, J., Ständer, S., &#38; Dugas, M. (2018). ODM Data Analysis—A tool for the
    automatic validation, monitoring and generation of generic descriptive statistics
    of patient data. <i>PLOS ONE</i>, <i>13</i>(6), Article e0199242. <a href="https://doi.org/10.1371/journal.pone.0199242">https://doi.org/10.1371/journal.pone.0199242</a>
  bjps: <b>Brix TJ <i>et al.</i></b> (2018) ODM Data Analysis—A Tool for the Automatic
    Validation, Monitoring and Generation of Generic Descriptive Statistics of Patient
    Data. <i>PLOS ONE</i> <b>13</b>.
  chicago: Brix, Tobias Johannes, Philipp Bruland, Saad Sarfraz, Jan Ernsting, Philipp
    Neuhaus, Michael Storck, Justin Doods, Sonja Ständer, and Martin Dugas. “ODM Data
    Analysis—A Tool for the Automatic Validation, Monitoring and Generation of Generic
    Descriptive Statistics of Patient Data.” <i>PLOS ONE</i> 13, no. 6 (2018). <a
    href="https://doi.org/10.1371/journal.pone.0199242">https://doi.org/10.1371/journal.pone.0199242</a>.
  chicago-de: Brix, Tobias Johannes, Philipp Bruland, Saad Sarfraz, Jan Ernsting,
    Philipp Neuhaus, Michael Storck, Justin Doods, Sonja Ständer und Martin Dugas.
    2018. ODM Data Analysis—A tool for the automatic validation, monitoring and generation
    of generic descriptive statistics of patient data. <i>PLOS ONE</i> 13, Nr. 6.
    doi:<a href="https://doi.org/10.1371/journal.pone.0199242">10.1371/journal.pone.0199242</a>,
    .
  din1505-2-1: '<span style="font-variant:small-caps;"><span style="font-variant:small-caps;">Brix,
    Tobias Johannes</span> ; <span style="font-variant:small-caps;">Bruland, Philipp</span>
    ; <span style="font-variant:small-caps;">Sarfraz, Saad</span> ; <span style="font-variant:small-caps;">Ernsting,
    Jan</span> ; <span style="font-variant:small-caps;">Neuhaus, Philipp</span> ;
    <span style="font-variant:small-caps;">Storck, Michael</span> ; <span style="font-variant:small-caps;">Doods,
    Justin</span> ; <span style="font-variant:small-caps;">Ständer, Sonja</span> ;
    u. a.</span>: ODM Data Analysis—A tool for the automatic validation, monitoring
    and generation of generic descriptive statistics of patient data. In: <i>PLOS
    ONE</i> Bd. 13.  San Francisco, California, US , Public Library of Science (PLoS)
    (2018), Nr. 6'
  havard: T.J. Brix, P. Bruland, S. Sarfraz, J. Ernsting, P. Neuhaus, M. Storck, J.
    Doods, S. Ständer, M. Dugas, ODM Data Analysis—A tool for the automatic validation,
    monitoring and generation of generic descriptive statistics of patient data, PLOS
    ONE. 13 (2018).
  ieee: 'T. J. Brix <i>et al.</i>, “ODM Data Analysis—A tool for the automatic validation,
    monitoring and generation of generic descriptive statistics of patient data,”
    <i>PLOS ONE</i>, vol. 13, no. 6, Art. no. e0199242, 2018, doi: <a href="https://doi.org/10.1371/journal.pone.0199242">10.1371/journal.pone.0199242</a>.'
  mla: Brix, Tobias Johannes, et al. “ODM Data Analysis—A Tool for the Automatic Validation,
    Monitoring and Generation of Generic Descriptive Statistics of Patient Data.”
    <i>PLOS ONE</i>, vol. 13, no. 6, e0199242, 2018, <a href="https://doi.org/10.1371/journal.pone.0199242">https://doi.org/10.1371/journal.pone.0199242</a>.
  short: T.J. Brix, P. Bruland, S. Sarfraz, J. Ernsting, P. Neuhaus, M. Storck, J.
    Doods, S. Ständer, M. Dugas, PLOS ONE 13 (2018).
  ufg: '<b>Brix, Tobias Johannes u. a.</b>: ODM Data Analysis—A tool for the automatic
    validation, monitoring and generation of generic descriptive statistics of patient
    data, in: <i>PLOS ONE</i> 13 (2018), H. 6.'
  van: Brix TJ, Bruland P, Sarfraz S, Ernsting J, Neuhaus P, Storck M, et al. ODM
    Data Analysis—A tool for the automatic validation, monitoring and generation of
    generic descriptive statistics of patient data. PLOS ONE. 2018;13(6).
date_created: 2024-07-18T12:11:02Z
date_updated: 2024-07-18T12:15:59Z
department:
- _id: DEP5024
doi: 10.1371/journal.pone.0199242
extern: '1'
external_id:
  pmid:
  - '29933373'
intvolume: '        13'
issue: '6'
language:
- iso: eng
place: ' San Francisco, California, US '
pmid: '1'
publication: PLOS ONE
publication_identifier:
  eissn:
  - 1932-6203
publication_status: published
publisher: Public Library of Science (PLoS)
status: public
title: ODM Data Analysis—A tool for the automatic validation, monitoring and generation
  of generic descriptive statistics of patient data
type: scientific_journal_article
user_id: '83781'
volume: 13
year: '2018'
...
---
_id: '11737'
abstract:
- lang: eng
  text: "Abstract\r\nBackground: Chronic kidney disease (CKD) is strongly associated
    with coronary artery disease (CAD). We established a prospective observational
    nationwide multicenter registry to evaluate current treatment and outcomes in
    patients with both CKD and angiographically documented CAD.\r\n\r\nMethods: In
    32 cardiological centers 3,352 CAD patients with ≥50% stenosis in at least one
    coronary artery were enrolled and classified according to their estimated glomerular
    filtration rate and proteinuria into one of five stages of CKD or as a control
    group.\r\n\r\nResults: 2,723 (81.2%) consecutively enrolled patients suffered
    from CKD. Compared to controls, CKD patients had a higher prevalence of diabetes,
    hypertension, peripheral artery diseases, heart failure, and valvular heart disease
    (each p<0.001). Myocardial infarctions (p = 0.02), coronary bypass grafting, valve
    replacements and pacemaker implantations had been recorded more frequently (each
    p<0.001). With advanced CKD, the number of diseased coronary vessels and the proportion
    of patients with reduced left ventricular ejection fraction (LVEF) increased significantly
    (both p<0.001). Percutaneous coronary interventions were performed less frequently
    (p<0.001) while coronary bypass grafting was recommended more often (p = 0.04)
    with advanced CKD. With regard to standard drugs in CAD treatment, prescriptions
    were higher in our registry than in previous reports, but beta-blockers (p = 0.008),
    and angiotensin-converting-enzyme inhibitors and/or angiotensin-receptor blockers
    (p<0.001) were given less often in higher CKD stages. In contrast, in the subgroup
    of patients with moderately to severely reduced LVEF the prescription rates did
    not differ between CKD stages. In-hospital mortality increased stepwise with each
    CKD stage (p = 0.02).\r\n\r\nConclusions: In line with other studies comprising
    CKD cohorts, patients' morbidity and in-hospital mortality increased with the
    degree of renal impairment. Although cardiologists' drug prescription rates in
    CAD-REF were higher than in previous studies, they were still lower especially
    in advanced CKD stages compared to cohorts treated by nephrologists."
article_number: e0148057
author:
- first_name: Holger
  full_name: Reinecke, Holger
  last_name: Reinecke
- first_name: Günter
  full_name: Breithardt, Günter
  last_name: Breithardt
- first_name: Christiane
  full_name: Engelbertz, Christiane
  last_name: Engelbertz
- first_name: Roland E.
  full_name: Schmieder, Roland E.
  last_name: Schmieder
- first_name: Manfred
  full_name: Fobker, Manfred
  last_name: Fobker
- first_name: Hans O.
  full_name: Pinnschmidt, Hans O.
  last_name: Pinnschmidt
- first_name: Boris
  full_name: Schmitz, Boris
  last_name: Schmitz
- first_name: Philipp
  full_name: Bruland, Philipp
  id: '75847'
  last_name: Bruland
  orcid: 0000-0001-6939-7630
- first_name: Karl
  full_name: Wegscheider, Karl
  last_name: Wegscheider
- first_name: Hermann
  full_name: Pavenstädt, Hermann
  last_name: Pavenstädt
- first_name: Eva
  full_name: Brand, Eva
  last_name: Brand
citation:
  ama: Reinecke H, Breithardt G, Engelbertz C, et al. Baseline Characteristics and
    Prescription Patterns of Standard Drugs in Patients with Angiographically Determined
    Coronary Artery Disease and Renal Failure (CAD-REF Registry). <i>PLOS ONE</i>.
    2016;11(2). doi:<a href="https://doi.org/10.1371/journal.pone.0148057">10.1371/journal.pone.0148057</a>
  apa: Reinecke, H., Breithardt, G., Engelbertz, C., Schmieder, R. E., Fobker, M.,
    Pinnschmidt, H. O., Schmitz, B., Bruland, P., Wegscheider, K., Pavenstädt, H.,
    &#38; Brand, E. (2016). Baseline Characteristics and Prescription Patterns of
    Standard Drugs in Patients with Angiographically Determined Coronary Artery Disease
    and Renal Failure (CAD-REF Registry). <i>PLOS ONE</i>, <i>11</i>(2), Article e0148057.
    <a href="https://doi.org/10.1371/journal.pone.0148057">https://doi.org/10.1371/journal.pone.0148057</a>
  bjps: <b>Reinecke H <i>et al.</i></b> (2016) Baseline Characteristics and Prescription
    Patterns of Standard Drugs in Patients with Angiographically Determined Coronary
    Artery Disease and Renal Failure (CAD-REF Registry). <i>PLOS ONE</i> <b>11</b>.
  chicago: Reinecke, Holger, Günter Breithardt, Christiane Engelbertz, Roland E. Schmieder,
    Manfred Fobker, Hans O. Pinnschmidt, Boris Schmitz, et al. “Baseline Characteristics
    and Prescription Patterns of Standard Drugs in Patients with Angiographically
    Determined Coronary Artery Disease and Renal Failure (CAD-REF Registry).” <i>PLOS
    ONE</i> 11, no. 2 (2016). <a href="https://doi.org/10.1371/journal.pone.0148057">https://doi.org/10.1371/journal.pone.0148057</a>.
  chicago-de: Reinecke, Holger, Günter Breithardt, Christiane Engelbertz, Roland E.
    Schmieder, Manfred Fobker, Hans O. Pinnschmidt, Boris Schmitz, u. a. 2016. Baseline
    Characteristics and Prescription Patterns of Standard Drugs in Patients with Angiographically
    Determined Coronary Artery Disease and Renal Failure (CAD-REF Registry). <i>PLOS
    ONE</i> 11, Nr. 2. doi:<a href="https://doi.org/10.1371/journal.pone.0148057">10.1371/journal.pone.0148057</a>,
    .
  din1505-2-1: '<span style="font-variant:small-caps;"><span style="font-variant:small-caps;">Reinecke,
    Holger</span> ; <span style="font-variant:small-caps;">Breithardt, Günter</span>
    ; <span style="font-variant:small-caps;">Engelbertz, Christiane</span> ; <span
    style="font-variant:small-caps;">Schmieder, Roland E.</span> ; <span style="font-variant:small-caps;">Fobker,
    Manfred</span> ; <span style="font-variant:small-caps;">Pinnschmidt, Hans O.</span>
    ; <span style="font-variant:small-caps;">Schmitz, Boris</span> ; <span style="font-variant:small-caps;">Bruland,
    Philipp</span> ; u. a.</span>: Baseline Characteristics and Prescription Patterns
    of Standard Drugs in Patients with Angiographically Determined Coronary Artery
    Disease and Renal Failure (CAD-REF Registry). In: <i>PLOS ONE</i> Bd. 11.  San
    Francisco, California, US , Public Library of Science (PLoS) (2016), Nr. 2'
  havard: H. Reinecke, G. Breithardt, C. Engelbertz, R.E. Schmieder, M. Fobker, H.O.
    Pinnschmidt, B. Schmitz, P. Bruland, K. Wegscheider, H. Pavenstädt, E. Brand,
    Baseline Characteristics and Prescription Patterns of Standard Drugs in Patients
    with Angiographically Determined Coronary Artery Disease and Renal Failure (CAD-REF
    Registry), PLOS ONE. 11 (2016).
  ieee: 'H. Reinecke <i>et al.</i>, “Baseline Characteristics and Prescription Patterns
    of Standard Drugs in Patients with Angiographically Determined Coronary Artery
    Disease and Renal Failure (CAD-REF Registry),” <i>PLOS ONE</i>, vol. 11, no. 2,
    Art. no. e0148057, 2016, doi: <a href="https://doi.org/10.1371/journal.pone.0148057">10.1371/journal.pone.0148057</a>.'
  mla: Reinecke, Holger, et al. “Baseline Characteristics and Prescription Patterns
    of Standard Drugs in Patients with Angiographically Determined Coronary Artery
    Disease and Renal Failure (CAD-REF Registry).” <i>PLOS ONE</i>, vol. 11, no. 2,
    e0148057, 2016, <a href="https://doi.org/10.1371/journal.pone.0148057">https://doi.org/10.1371/journal.pone.0148057</a>.
  short: H. Reinecke, G. Breithardt, C. Engelbertz, R.E. Schmieder, M. Fobker, H.O.
    Pinnschmidt, B. Schmitz, P. Bruland, K. Wegscheider, H. Pavenstädt, E. Brand,
    PLOS ONE 11 (2016).
  ufg: '<b>Reinecke, Holger u. a.</b>: Baseline Characteristics and Prescription Patterns
    of Standard Drugs in Patients with Angiographically Determined Coronary Artery
    Disease and Renal Failure (CAD-REF Registry), in: <i>PLOS ONE</i> 11 (2016), H.
    2.'
  van: Reinecke H, Breithardt G, Engelbertz C, Schmieder RE, Fobker M, Pinnschmidt
    HO, et al. Baseline Characteristics and Prescription Patterns of Standard Drugs
    in Patients with Angiographically Determined Coronary Artery Disease and Renal
    Failure (CAD-REF Registry). PLOS ONE. 2016;11(2).
date_created: 2024-07-18T12:35:52Z
date_updated: 2024-07-18T12:37:39Z
doi: 10.1371/journal.pone.0148057
extern: '1'
external_id:
  pmid:
  - '26859890'
intvolume: '        11'
issue: '2'
language:
- iso: eng
place: ' San Francisco, California, US '
pmid: '1'
publication: PLOS ONE
publication_identifier:
  eissn:
  - 1932-6203
publication_status: published
publisher: Public Library of Science (PLoS)
status: public
title: Baseline Characteristics and Prescription Patterns of Standard Drugs in Patients
  with Angiographically Determined Coronary Artery Disease and Renal Failure (CAD-REF
  Registry)
type: scientific_journal_article
user_id: '83781'
volume: 11
year: '2016'
...
---
_id: '12246'
abstract:
- lang: eng
  text: In lakes, trophic change and climate change shift the relationship between
    nutrients and physical factors, like temperature and photoperiod, and interactions
    between these factors should affect the growth of phytoplankton species differently.
    We therefore determined the relationship between P-limited specific growth rates
    and P-quota (biovolume basis) of Stephanodiscus minutulus and Nitzschia acicularis
    (diatoms) at or near light saturation in axenic, semi-continuous culture at 10,
    15 and 20 °C and at 6, 9 and 12 h d−1 photoperiod. Photoperiod treatments were
    performed at constant daily light exposure to allow comparison. Under these conditions,
    we also performed competition experiments and estimated relative P-uptake rates
    of the species. Temperature strongly affected P-limited growth rates and relative
    P uptake rates, whereas photoperiod only affected maximum growth rates. S. minutulus
    used internal P more efficiently than N. acicularis. N. acicularis was the superior
    competitor for P due to a higher relative uptake rate and its superiority increased
    with increasing temperature and photoperiod. S. minutulus conformed to the Droop
    relationship but N. acicularis did not. A model with a temperature-dependent normalised
    half-saturation coefficient adequately described the factor interactions of both
    species. The temperature dependence of the quota model reflected each species’
    specific adaptation to its ecological niche. The results demonstrate that increases
    in temperature or photoperiod can partially compensate for a decrease in P-quota
    under moderately limiting conditions, like during spring in temperate lakes. Thus
    warming may counteract de-eutrophication to some degree and a relative shift in
    growth factors can influence the phytoplankton species composition.
article_number: e102367
author:
- first_name: Tom
  full_name: Shatwell, Tom
  id: '86424'
  last_name: Shatwell
  orcid: 0000-0002-4520-7916
- first_name: Jan
  full_name: Köhler, Jan
  last_name: Köhler
- first_name: Andreas
  full_name: Nicklisch, Andreas
  last_name: Nicklisch
citation:
  ama: Shatwell T, Köhler J, Nicklisch A. Temperature and Photoperiod Interactions
    with Phosphorus-Limited Growth and Competition of Two Diatoms. <i>PLoS ONE</i>.
    2014;9(7). doi:<a href="https://doi.org/10.1371/journal.pone.0102367">10.1371/journal.pone.0102367</a>
  apa: Shatwell, T., Köhler, J., &#38; Nicklisch, A. (2014). Temperature and Photoperiod
    Interactions with Phosphorus-Limited Growth and Competition of Two Diatoms. <i>PLoS
    ONE</i>, <i>9</i>(7), Article e102367. <a href="https://doi.org/10.1371/journal.pone.0102367">https://doi.org/10.1371/journal.pone.0102367</a>
  bjps: <b>Shatwell T, Köhler J and Nicklisch A</b> (2014) Temperature and Photoperiod
    Interactions with Phosphorus-Limited Growth and Competition of Two Diatoms. <i>PLoS
    ONE</i> <b>9</b>.
  chicago: Shatwell, Tom, Jan Köhler, and Andreas Nicklisch. “Temperature and Photoperiod
    Interactions with Phosphorus-Limited Growth and Competition of Two Diatoms.” <i>PLoS
    ONE</i> 9, no. 7 (2014). <a href="https://doi.org/10.1371/journal.pone.0102367">https://doi.org/10.1371/journal.pone.0102367</a>.
  chicago-de: Shatwell, Tom, Jan Köhler und Andreas Nicklisch. 2014. Temperature and
    Photoperiod Interactions with Phosphorus-Limited Growth and Competition of Two
    Diatoms. <i>PLoS ONE</i> 9, Nr. 7. doi:<a href="https://doi.org/10.1371/journal.pone.0102367">10.1371/journal.pone.0102367</a>,
    .
  din1505-2-1: '<span style="font-variant:small-caps;">Shatwell, Tom</span> ; <span
    style="font-variant:small-caps;">Köhler, Jan</span> ; <span style="font-variant:small-caps;">Nicklisch,
    Andreas</span>: Temperature and Photoperiod Interactions with Phosphorus-Limited
    Growth and Competition of Two Diatoms. In: <i>PLoS ONE</i> Bd. 9. San Francisco,
    California, US , Public Library of Science (PLoS) (2014), Nr. 7'
  havard: T. Shatwell, J. Köhler, A. Nicklisch, Temperature and Photoperiod Interactions
    with Phosphorus-Limited Growth and Competition of Two Diatoms, PLoS ONE. 9 (2014).
  ieee: 'T. Shatwell, J. Köhler, and A. Nicklisch, “Temperature and Photoperiod Interactions
    with Phosphorus-Limited Growth and Competition of Two Diatoms,” <i>PLoS ONE</i>,
    vol. 9, no. 7, Art. no. e102367, 2014, doi: <a href="https://doi.org/10.1371/journal.pone.0102367">10.1371/journal.pone.0102367</a>.'
  mla: Shatwell, Tom, et al. “Temperature and Photoperiod Interactions with Phosphorus-Limited
    Growth and Competition of Two Diatoms.” <i>PLoS ONE</i>, vol. 9, no. 7, e102367,
    2014, <a href="https://doi.org/10.1371/journal.pone.0102367">https://doi.org/10.1371/journal.pone.0102367</a>.
  short: T. Shatwell, J. Köhler, A. Nicklisch, PLoS ONE 9 (2014).
  ufg: '<b>Shatwell, Tom/Köhler, Jan/Nicklisch, Andreas</b>: Temperature and Photoperiod
    Interactions with Phosphorus-Limited Growth and Competition of Two Diatoms, in:
    <i>PLoS ONE</i> 9 (2014), H. 7.'
  van: Shatwell T, Köhler J, Nicklisch A. Temperature and Photoperiod Interactions
    with Phosphorus-Limited Growth and Competition of Two Diatoms. PLoS ONE. 2014;9(7).
date_created: 2024-12-08T20:40:45Z
date_updated: 2024-12-09T09:09:08Z
department:
- _id: DEP8022
doi: 10.1371/journal.pone.0102367
extern: '1'
intvolume: '         9'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1371/journal.pone.0102367
oa: '1'
place: 'San Francisco, California, US '
publication: PLoS ONE
publication_identifier:
  eissn:
  - 1932-6203
publication_status: published
publisher: Public Library of Science (PLoS)
quality_controlled: '1'
status: public
title: Temperature and Photoperiod Interactions with Phosphorus-Limited Growth and
  Competition of Two Diatoms
type: scientific_journal_article
user_id: '83781'
volume: 9
year: '2014'
...
---
_id: '12987'
abstract:
- lang: eng
  text: Mutations in the ABC transporter ABCC6 were recently identified as cause of
    Pseudoxanthoma elasticum (PXE), a rare genetic disorder characterized by progressive
    mineralization of elastic fibers. We used an untargeted metabolic approach to
    identify biochemical differences between human dermal fibroblasts from healthy
    controls and PXE patients in an attempt to find a link between ABCC6 deficiency,
    cellular metabolic alterations and disease pathogenesis. 358 compounds were identified
    by mass spectrometry covering lipids, amino acids, peptides, carbohydrates, nucleotides,
    vitamins and cofactors, xenobiotics and energy metabolites. We found substantial
    differences in glycerophospholipid composition, leucine dipeptides, and polypeptides
    as well as alterations in pantothenate and guanine metabolism to be significantly
    associated with PXE pathogenesis. These findings can be linked to extracellular
    matrix remodeling and increased oxidative stress, which reflect characteristic
    hallmarks of PXE. Our study could facilitate a better understanding of biochemical
    pathways involved in soft tissue mineralization.
article_number: e108336
author:
- first_name: Patricia
  full_name: Kuzaj, Patricia
  last_name: Kuzaj
- first_name: Joachim
  full_name: Kuhn, Joachim
  last_name: Kuhn
- first_name: Ryan D.
  full_name: Michalek, Ryan D.
  last_name: Michalek
- first_name: Edward D.
  full_name: Karoly, Edward D.
  last_name: Karoly
- first_name: Isabel
  full_name: Faust, Isabel
  last_name: Faust
- first_name: Mareike
  full_name: Dabisch-Ruthe, Mareike
  id: '66516'
  last_name: Dabisch-Ruthe
  orcid: https://orcid.org/0009-0008-7644-0826
- first_name: Cornelius
  full_name: Knabbe, Cornelius
  last_name: Knabbe
- first_name: Doris
  full_name: Hendig, Doris
  last_name: Hendig
citation:
  ama: Kuzaj P, Kuhn J, Michalek RD, et al. Large-Scaled Metabolic Profiling of Human
    Dermal Fibroblasts Derived from Pseudoxanthoma Elasticum Patients and Healthy
    Controls. <i>PLOS ONE / Public Library of Science </i>. 2014;9(9). doi:<a href="https://doi.org/10.1371/journal.pone.0108336">10.1371/journal.pone.0108336</a>
  apa: Kuzaj, P., Kuhn, J., Michalek, R. D., Karoly, E. D., Faust, I., Dabisch-Ruthe,
    M., Knabbe, C., &#38; Hendig, D. (2014). Large-Scaled Metabolic Profiling of Human
    Dermal Fibroblasts Derived from Pseudoxanthoma Elasticum Patients and Healthy
    Controls. <i>PLOS ONE / Public Library of Science </i>, <i>9</i>(9), Article e108336.
    <a href="https://doi.org/10.1371/journal.pone.0108336">https://doi.org/10.1371/journal.pone.0108336</a>
  bjps: <b>Kuzaj P <i>et al.</i></b> (2014) Large-Scaled Metabolic Profiling of Human
    Dermal Fibroblasts Derived from Pseudoxanthoma Elasticum Patients and Healthy
    Controls. <i>PLOS ONE / Public Library of Science </i> <b>9</b>.
  chicago: Kuzaj, Patricia, Joachim Kuhn, Ryan D. Michalek, Edward D. Karoly, Isabel
    Faust, Mareike Dabisch-Ruthe, Cornelius Knabbe, and Doris Hendig. “Large-Scaled
    Metabolic Profiling of Human Dermal Fibroblasts Derived from Pseudoxanthoma Elasticum
    Patients and Healthy Controls.” <i>PLOS ONE / Public Library of Science </i> 9,
    no. 9 (2014). <a href="https://doi.org/10.1371/journal.pone.0108336">https://doi.org/10.1371/journal.pone.0108336</a>.
  chicago-de: Kuzaj, Patricia, Joachim Kuhn, Ryan D. Michalek, Edward D. Karoly, Isabel
    Faust, Mareike Dabisch-Ruthe, Cornelius Knabbe und Doris Hendig. 2014. Large-Scaled
    Metabolic Profiling of Human Dermal Fibroblasts Derived from Pseudoxanthoma Elasticum
    Patients and Healthy Controls. <i>PLOS ONE / Public Library of Science </i> 9,
    Nr. 9. doi:<a href="https://doi.org/10.1371/journal.pone.0108336">10.1371/journal.pone.0108336</a>,
    .
  din1505-2-1: '<span style="font-variant:small-caps;">Kuzaj, Patricia</span> ; <span
    style="font-variant:small-caps;">Kuhn, Joachim</span> ; <span style="font-variant:small-caps;">Michalek,
    Ryan D.</span> ; <span style="font-variant:small-caps;">Karoly, Edward D.</span>
    ; <span style="font-variant:small-caps;">Faust, Isabel</span> ; <span style="font-variant:small-caps;">Dabisch-Ruthe,
    Mareike</span> ; <span style="font-variant:small-caps;">Knabbe, Cornelius</span>
    ; <span style="font-variant:small-caps;">Hendig, Doris</span>: Large-Scaled Metabolic
    Profiling of Human Dermal Fibroblasts Derived from Pseudoxanthoma Elasticum Patients
    and Healthy Controls. In: <i>PLOS ONE / Public Library of Science </i> Bd. 9.
    San Francisco, California, US, Public Library of Science (PLoS) (2014), Nr. 9'
  havard: P. Kuzaj, J. Kuhn, R.D. Michalek, E.D. Karoly, I. Faust, M. Dabisch-Ruthe,
    C. Knabbe, D. Hendig, Large-Scaled Metabolic Profiling of Human Dermal Fibroblasts
    Derived from Pseudoxanthoma Elasticum Patients and Healthy Controls, PLOS ONE
    / Public Library of Science . 9 (2014).
  ieee: 'P. Kuzaj <i>et al.</i>, “Large-Scaled Metabolic Profiling of Human Dermal
    Fibroblasts Derived from Pseudoxanthoma Elasticum Patients and Healthy Controls,”
    <i>PLOS ONE / Public Library of Science </i>, vol. 9, no. 9, Art. no. e108336,
    2014, doi: <a href="https://doi.org/10.1371/journal.pone.0108336">10.1371/journal.pone.0108336</a>.'
  mla: Kuzaj, Patricia, et al. “Large-Scaled Metabolic Profiling of Human Dermal Fibroblasts
    Derived from Pseudoxanthoma Elasticum Patients and Healthy Controls.” <i>PLOS
    ONE / Public Library of Science </i>, vol. 9, no. 9, e108336, 2014, <a href="https://doi.org/10.1371/journal.pone.0108336">https://doi.org/10.1371/journal.pone.0108336</a>.
  short: P. Kuzaj, J. Kuhn, R.D. Michalek, E.D. Karoly, I. Faust, M. Dabisch-Ruthe,
    C. Knabbe, D. Hendig, PLOS ONE / Public Library of Science  9 (2014).
  ufg: '<b>Kuzaj, Patricia u. a.</b>: Large-Scaled Metabolic Profiling of Human Dermal
    Fibroblasts Derived from Pseudoxanthoma Elasticum Patients and Healthy Controls,
    in: <i>PLOS ONE / Public Library of Science </i> 9 (2014), H. 9.'
  van: Kuzaj P, Kuhn J, Michalek RD, Karoly ED, Faust I, Dabisch-Ruthe M, et al. Large-Scaled
    Metabolic Profiling of Human Dermal Fibroblasts Derived from Pseudoxanthoma Elasticum
    Patients and Healthy Controls. PLOS ONE / Public Library of Science . 2014;9(9).
date_created: 2025-06-17T06:54:30Z
date_updated: 2025-06-17T13:49:26Z
department:
- _id: DEP4010
doi: 10.1371/journal.pone.0108336
intvolume: '         9'
issue: '9'
language:
- iso: eng
place: San Francisco, California, US
publication: 'PLOS ONE / Public Library of Science '
publication_identifier:
  eissn:
  - 1932-6203
publication_status: published
publisher: Public Library of Science (PLoS)
quality_controlled: '1'
status: public
title: Large-Scaled Metabolic Profiling of Human Dermal Fibroblasts Derived from Pseudoxanthoma
  Elasticum Patients and Healthy Controls
type: scientific_journal_article
user_id: '83781'
volume: 9
year: '2014'
...