@misc{13315,
  abstract     = {{Determining cell density and viability with (semi‐)automated methods enables rapid cell cultivation analysis. However, scientific validation is required, typically by comparing results to manual counting. To address this, we present a method to evaluate and compare two cell counting methods exemplified by a manual and a semi‐automated method (Countstar BioTech). Experiments followed validation parameters aligned with the International Council for Harmonization (ICH) Q2(R1) guideline and a dilution series design based on ISO 20391‐2:2019. Both the semi‐automated and manual methods showed comparable specificity and linearity for Chinese hamster ovary (CHO)‐K1 cells. The semi‐automated method exhibited superior repeatability for total cell density, whereas cell viability results showed no significant difference.}},
  author       = {{Uhlendorff, Selina and Odefey, Ulrich and Frahm, Björn and Pein-Hackelbusch, Miriam}},
  booktitle    = {{Chemie Ingenieur Technik}},
  issn         = {{1522-2640}},
  keywords     = {{Cell density, Cell enumeration, Cell viability, CHO-K1}},
  number       = {{1-2}},
  pages        = {{57–68}},
  publisher    = {{Wiley}},
  title        = {{{Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture}}},
  doi          = {{10.1002/cite.70048}},
  volume       = {{98}},
  year         = {{2025}},
}

@misc{12402,
  abstract     = {{In anaerobic technology, pH values are crucial for targeted volatile fatty acid production. While pH dynamics can be modeled using the Anaerobic Digestion Model No. 1 (ADM1), simulation results may be biased. To address this issue, the pH prediction routine of Visual Water, a specialized water chemistry simulator, was validated. Unlike ADM1, it accounts for ionic strength and activities while also providing an automated uncertainty analysis. The analysis revealed Visual Water simulations to better fit measured pH data from acidic solutions in a miniaturized stirred-tank reactor.}},
  author       = {{Kosse, Pascal and Hernández Rodriguez, Tanja and Frahm, Björn and Lübken, Manfred and Wichern, Marc}},
  booktitle    = {{Chemie Ingenieur Technik}},
  issn         = {{1522-2640}},
  keywords     = {{Anaerobic Digestion Model No. 1 (ADM1), Anaerobic technology, pH simulation, Uncertainty assessment, Visual Water}},
  number       = {{4}},
  pages        = {{528--534}},
  publisher    = {{Wiley}},
  title        = {{{Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator}}},
  doi          = {{10.1002/cite.202300188}},
  volume       = {{96}},
  year         = {{2024}},
}

@misc{11385,
  abstract     = {{Accurate pH calculations are essential for scientists across different disciplines to design optimal reactor solutions, but they can be arduous to calculate for complex acid-base solutions. Visual Water is a powerful software tool that provides accurate pH calculations with automated mathematical uncertainty analysis. Its workflow is presented and validated using acids and bases, showing a deviation of < 0.2 pH units between measured and calculated pH values. This highlights the software's reliability, which can help to simplify the work of non-experts in water chemistry.}},
  author       = {{Kosse, Pascal and Hernández Rodriguez, Tanja and Frahm, Björn and Lübken, Manfred and Wichern, Marc}},
  booktitle    = {{Chemie Ingenieur Technik}},
  issn         = {{1522-2640}},
  keywords     = {{Acid-base equilibria, Carboxylic acids, Dissociation constants, pH calculation software, Uncertainty assessment}},
  number       = {{12}},
  pages        = {{1960--1969}},
  publisher    = {{Wiley}},
  title        = {{{Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations}}},
  doi          = {{10.1002/cite.202300082}},
  volume       = {{95}},
  year         = {{2023}},
}

@article{2823,
  author       = {{Müller, Ulrich and Triantafillaki, C. and Stegmann, I. and Wolf, A.}},
  issn         = {{0009-286X}},
  journal      = {{Chemie - Ingenieur - Technik : Verfahrenstechnik, technische Chemie, Apparatewesen, Biotechnologie}},
  number       = {{8}},
  pages        = {{1156 -- 1157}},
  publisher    = {{Wiley-VCH}},
  title        = {{{Gegenstrominjektionsverfahren zur Herstellung von Emulsionen}}},
  volume       = {{81}},
  year         = {{2009}},
}

@article{2824,
  author       = {{Müller, Ulrich and Lilie, Markus and Burgemeister, S. and Flaschel, E. and Friehs, K.}},
  issn         = {{0009-286X}},
  journal      = {{Chemie - Ingenieur - Technik : Verfahrenstechnik, technische Chemie, Apparatewesen, Biotechnologie}},
  number       = {{8}},
  pages        = {{1174}},
  title        = {{{Nachweis mechanischer Entkeimungseffekte bei der mtVDV-Entkeimung}}},
  volume       = {{81}},
  year         = {{2009}},
}

@article{2825,
  author       = {{Müller, Ulrich and Lilie, Markus and Zakowski, M. and Wilhelm, Patrick and Flaschel, E. and Friehs, K.}},
  issn         = {{0009-286X}},
  journal      = {{Chemie-Ingenieur-Technik}},
  number       = {{8}},
  pages        = {{1265}},
  publisher    = {{WILEY-VCH Verlag GmbH & Co. KGaA}},
  title        = {{{Nicht isotherme Modellierung der thermischen Inaktivierung in einem mtVDV-Prozess}}},
  doi          = {{10.1002/cite.200950333}},
  volume       = {{81}},
  year         = {{2009}},
}

@article{2826,
  author       = {{Müller, Ulrich and Gockel, S. and Ridder, M. and Wilhelm, Patrick}},
  issn         = {{0009-286X}},
  journal      = {{Chemie-Ingenieur-Technik}},
  number       = {{9}},
  pages        = {{1298 -- 1299}},
  publisher    = {{WILEY-VCH Verlag GmbH & Co. KGaA}},
  title        = {{{Dynamische Gefriertrocknung von Starterkulturen}}},
  doi          = {{10.1002/cite.200950313}},
  volume       = {{81}},
  year         = {{2009}},
}

@misc{2348,
  author       = {{Frahm, Björn and Kirchner, S. and Kauling, J. and Brod, H. and Langer, U. and Bödeker, B.}},
  booktitle    = {{Chemie Ingenieur Technik}},
  issn         = {{0009-286X}},
  number       = {{7}},
  pages        = {{1052--1058}},
  publisher    = {{WILEY-VCH Verlag}},
  title        = {{{Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien}}},
  doi          = {{10.1002/cite.200700070}},
  volume       = {{79}},
  year         = {{2007}},
}

@article{2832,
  author       = {{Müller, Ulrich and Lilie, Markus and Wilhelm, Patrick}},
  issn         = {{0009-286X}},
  journal      = {{Chemie-Ingenieur-Technik}},
  number       = {{9}},
  pages        = {{1243--1244}},
  publisher    = {{WILEY-VCH Verlag GmbH & Co. KGaA}},
  title        = {{{Anwendung der Flash-Verdampfung zur Entkeimung pflanzlicher Materialien}}},
  doi          = {{10.1002/cite.200650159}},
  volume       = {{78}},
  year         = {{2006}},
}

@misc{2347,
  author       = {{Frahm, Björn and Lane, Paul and Munack, Axel and Pörtner, Ralf}},
  booktitle    = {{Chemie Ingenieur Technik}},
  issn         = {{1522-2640}},
  number       = {{4}},
  pages        = {{429--435}},
  publisher    = {{WILEY-VCH Verlag}},
  title        = {{{Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode}}},
  doi          = {{10.1002/cite.200407094}},
  volume       = {{77}},
  year         = {{2005}},
}

@article{2838,
  author       = {{Müller, Ulrich and Lilie, Markus and Wilhelm, Patrick}},
  issn         = {{0009-286X}},
  journal      = {{Chemie-Ingenieur-Technik}},
  number       = {{10}},
  pages        = {{1602--1605}},
  publisher    = {{WILEY-VCH Verlag GmbH & Co. KGaA}},
  title        = {{{Mechanische Effekte bei der Sattdampfentkeimung}}},
  doi          = {{10.1002/cite.200403406}},
  volume       = {{76}},
  year         = {{2004}},
}

@article{4964,
  author       = {{Dohmann, Joachim}},
  issn         = {{0009-286X}},
  journal      = {{Chemie Ingenieur Technik}},
  pages        = {{534--538}},
  title        = {{{Sekundärdispersion und Koagulation von Tropfen in sich überschneidenden Sprays}}},
  doi          = {{10.1002/cite.330700509}},
  year         = {{2004}},
}

@misc{2343,
  author       = {{Frahm, Björn and Hass, V. C. and Lane, P. and Munack, A. and Märkl, H. and Pörtner, R.}},
  booktitle    = {{Chemie Ingenieur Technik}},
  issn         = {{1522-2640}},
  number       = {{4}},
  pages        = {{457--460}},
  publisher    = {{WILEY-VCH Verlag}},
  title        = {{{Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung}}},
  doi          = {{10.1002/cite.200390093}},
  volume       = {{75}},
  year         = {{2003}},
}