[{"publication_identifier":{"issn":["0178-7888"],"eissn":["1867-1632"]},"date_updated":"2025-10-06T12:11:00Z","user_id":"83781","_id":"13233","keyword":["Atranone","Secondary metabolite","Stachybotrys","Stachatranone","Stachybatranone"],"doi":"10.1007/s12550-025-00609-x","type":"scientific_journal_article","title":"Atranone-an underestimated secondary metabolite?","author":[{"orcid":"https://orcid.org/0009-0008-7644-0826","full_name":"Dabisch-Ruthe, Mareike","first_name":"Mareike","id":"66516","last_name":"Dabisch-Ruthe"},{"full_name":"Pfannebecker, Jens","last_name":"Pfannebecker","id":"45690","first_name":"Jens","orcid":"0009-0005-4133-5442"},{"full_name":"Straubinger, Reinhard K.","first_name":"Reinhard K.","last_name":"Straubinger"},{"full_name":"Ebel, Frank","first_name":"Frank","last_name":"Ebel"},{"last_name":"Ulrich","first_name":"Sebastian","id":"85847","full_name":"Ulrich, Sebastian","orcid":"0000-0002-4511-9537"}],"publication_status":"published","year":"2025","publication":"Mycotoxin Research","department":[{"_id":"DEP4010"}],"language":[{"iso":"eng"}],"status":"public","place":"Berlin ; Heidelberg","citation":{"havard":"M. Dabisch-Ruthe, J. Pfannebecker, R.K. Straubinger, F. Ebel, S. Ulrich, Atranone-an underestimated secondary metabolite?, Mycotoxin Research. (2025).","din1505-2-1":"<span style=\"font-variant:small-caps;\">Dabisch-Ruthe, Mareike</span> ; <span style=\"font-variant:small-caps;\">Pfannebecker, Jens</span> ; <span style=\"font-variant:small-caps;\">Straubinger, Reinhard K.</span> ; <span style=\"font-variant:small-caps;\">Ebel, Frank</span> ; <span style=\"font-variant:small-caps;\">Ulrich, Sebastian</span>: Atranone-an underestimated secondary metabolite? In: <i>Mycotoxin Research</i>. Berlin ; Heidelberg, Springer (2025)","mla":"Dabisch-Ruthe, Mareike, et al. “Atranone-an Underestimated Secondary Metabolite?” <i>Mycotoxin Research</i>, 2025, <a href=\"https://doi.org/10.1007/s12550-025-00609-x\">https://doi.org/10.1007/s12550-025-00609-x</a>.","apa":"Dabisch-Ruthe, M., Pfannebecker, J., Straubinger, R. K., Ebel, F., &#38; Ulrich, S. (2025). Atranone-an underestimated secondary metabolite? <i>Mycotoxin Research</i>. <a href=\"https://doi.org/10.1007/s12550-025-00609-x\">https://doi.org/10.1007/s12550-025-00609-x</a>","van":"Dabisch-Ruthe M, Pfannebecker J, Straubinger RK, Ebel F, Ulrich S. Atranone-an underestimated secondary metabolite? Mycotoxin Research. 2025;","short":"M. Dabisch-Ruthe, J. Pfannebecker, R.K. Straubinger, F. Ebel, S. Ulrich, Mycotoxin Research (2025).","ieee":"M. Dabisch-Ruthe, J. Pfannebecker, R. K. Straubinger, F. Ebel, and S. Ulrich, “Atranone-an underestimated secondary metabolite?,” <i>Mycotoxin Research</i>, 2025, doi: <a href=\"https://doi.org/10.1007/s12550-025-00609-x\">10.1007/s12550-025-00609-x</a>.","bjps":"<b>Dabisch-Ruthe M <i>et al.</i></b> (2025) Atranone-an Underestimated Secondary Metabolite? <i>Mycotoxin Research</i>.","chicago-de":"Dabisch-Ruthe, Mareike, Jens Pfannebecker, Reinhard K. Straubinger, Frank Ebel und Sebastian Ulrich. 2025. Atranone-an underestimated secondary metabolite? <i>Mycotoxin Research</i>. doi:<a href=\"https://doi.org/10.1007/s12550-025-00609-x\">10.1007/s12550-025-00609-x</a>, .","chicago":"Dabisch-Ruthe, Mareike, Jens Pfannebecker, Reinhard K. Straubinger, Frank Ebel, and Sebastian Ulrich. “Atranone-an Underestimated Secondary Metabolite?” <i>Mycotoxin Research</i>, 2025. <a href=\"https://doi.org/10.1007/s12550-025-00609-x\">https://doi.org/10.1007/s12550-025-00609-x</a>.","ufg":"<b>Dabisch-Ruthe, Mareike u. a.</b>: Atranone-an underestimated secondary metabolite?, in: <i>Mycotoxin Research</i> (2025).","ama":"Dabisch-Ruthe M, Pfannebecker J, Straubinger RK, Ebel F, Ulrich S. Atranone-an underestimated secondary metabolite? <i>Mycotoxin Research</i>. Published online 2025. doi:<a href=\"https://doi.org/10.1007/s12550-025-00609-x\">10.1007/s12550-025-00609-x</a>"},"abstract":[{"text":"Atranones are secondary metabolites produced by Stachybotrys chartarum, a mold frequently found in water-damaged indoor environments. In contrast to the well-characterized and highly toxic macrocyclic trichothecenes, atranones have received relatively limited scientific attention. Approximately 60% of S. chartarum isolates from indoor environments produce atranones, while 40% form macrocyclic trichothecenes. No strain has been shown to produce both, indicating that the biosynthetic pathways for these two mycotoxin classes are mutually exclusive. Atranones are dolabellane-like diterpenoids synthesized from geranylgeranyl pyrophosphate through multiple enzymatic steps encoded by a specific core gene cluster. While the genetic structure of this cluster has been elucidated, its regulatory mechanisms remain poorly understood. Notably, although atranone-producing S. chartarum strains have been isolated from indoor settings, no study has yet confirmed the actual production of atranones in indoor environments, leaving the question of real-world exposure unresolved. Experimental studies in cell cultures and animal models indicate that atranones possess pro-inflammatory and cytotoxic properties, including the induction of apoptosis and cell cycle arrest. Atranone Q has demonstrated antitumor activity against osteosarcoma cells in vitro, and more recently identified derivatives such as stachatranone and stachybatranone have shown preliminary cardioprotective effects under ischemic conditions. However, these pharmacological effects remain exploratory and require further validation in in vivo models. Major knowledge gaps concern the environmental triggers for atranone biosynthesis, their regulation, actual presence in built environments, and potential health risks. These areas represent key priorities for future research. ","lang":"eng"}],"publisher":"Springer","date_created":"2025-10-01T09:20:35Z"},{"title":"Truncated satratoxin gene clusters in selected isolates of the atranone chemotype of Stachybotrys chartarum (Ehrenb.) S. Hughes","author":[{"full_name":"Ulrich, Sebastian","id":"85847","first_name":"Sebastian","last_name":"Ulrich","orcid":"0000-0002-4511-9537"},{"first_name":"Ludwig","last_name":"Niessen","full_name":"Niessen, Ludwig"},{"first_name":"Julia","last_name":"Ekruth","full_name":"Ekruth, Julia"},{"full_name":"Schäfer, Cornelius","last_name":"Schäfer","first_name":"Cornelius"},{"last_name":"Kaltner","first_name":"Florian","full_name":"Kaltner, Florian"},{"full_name":"Gottschalk, Christoph","last_name":"Gottschalk","first_name":"Christoph"}],"publication":"Mycotoxin Research","year":"2019","department":[{"_id":"DEP4010"}],"language":[{"iso":"eng"}],"publisher":"Springer","abstract":[{"text":"The fungus Stachybotrys (S.) chartarum was isolated from culinary herbs, damp building materials, and improperly stored animal forage. Two distinct chemotypes of the fungus were described that produced either high-cytotoxic macrocyclic trichothecenes (S type) or low-cytotoxic atranones (A type). Recently, two distinct gene clusters were described that were found to be necessary for the biosynthesis of either macrocyclic trichothecenes (21 SAT (Satratoxin) genes) or atranones (14 ATR (Atranone) genes). In the current study, PCR primers were designed to detect SAT and ATR genes in 19 S. chartarum chemotype S and eight S. chartarum chemotype A strains. Our analysis revealed the existence of three different genotypes: satratoxin-producing strains that harbored all SAT genes but lacked the ATR gene cluster (genotype S), non-satratoxin-producing strains that possessed the ATR genes but lacked SAT genes (genotype A), and a hitherto undescribed hybrid genotype among non-satratoxin-producing strains that harbored all ATR genes and an incomplete set of SAT genes (genotype H). In order to improve the discrimination of genotypes, a triplex PCR assay was developed and applied for the analysis of S. chartarum and S. chlorohalonata cultures. The results show that genes for macrocyclic trichothecenes and atranones are not mutually exclusive in S. chartarum. Correlation of the new genotype-based concept with mycotoxin production data shows also that macrocyclic trichothecenes are exclusively produced by S. chartarum genotype S strains.","lang":"eng"}],"date_created":"2025-06-15T10:19:53Z","issue":"1","extern":"1","date_updated":"2025-06-18T11:20:11Z","intvolume":"        36","user_id":"83781","doi":"10.1007/s12550-019-00371-x","volume":36,"type":"scientific_journal_article","quality_controlled":"1","publication_status":"published","status":"public","place":"Berlin ; Heidelberg","citation":{"ufg":"<b>Ulrich, Sebastian u. a.</b>: Truncated satratoxin gene clusters in selected isolates of the atranone chemotype of Stachybotrys chartarum (Ehrenb.) S. Hughes, in: <i>Mycotoxin Research</i> 36 (2019), H. 1,  S. 83–91.","ama":"Ulrich S, Niessen L, Ekruth J, Schäfer C, Kaltner F, Gottschalk C. Truncated satratoxin gene clusters in selected isolates of the atranone chemotype of Stachybotrys chartarum (Ehrenb.) S. Hughes. <i>Mycotoxin Research</i>. 2019;36(1):83-91. doi:<a href=\"https://doi.org/10.1007/s12550-019-00371-x\">10.1007/s12550-019-00371-x</a>","chicago":"Ulrich, Sebastian, Ludwig Niessen, Julia Ekruth, Cornelius Schäfer, Florian Kaltner, and Christoph Gottschalk. “Truncated Satratoxin Gene Clusters in Selected Isolates of the Atranone Chemotype of Stachybotrys Chartarum (Ehrenb.) S. Hughes.” <i>Mycotoxin Research</i> 36, no. 1 (2019): 83–91. <a href=\"https://doi.org/10.1007/s12550-019-00371-x\">https://doi.org/10.1007/s12550-019-00371-x</a>.","chicago-de":"Ulrich, Sebastian, Ludwig Niessen, Julia Ekruth, Cornelius Schäfer, Florian Kaltner und Christoph Gottschalk. 2019. Truncated satratoxin gene clusters in selected isolates of the atranone chemotype of Stachybotrys chartarum (Ehrenb.) S. Hughes. <i>Mycotoxin Research</i> 36, Nr. 1: 83–91. doi:<a href=\"https://doi.org/10.1007/s12550-019-00371-x\">10.1007/s12550-019-00371-x</a>, .","ieee":"S. Ulrich, L. Niessen, J. Ekruth, C. Schäfer, F. Kaltner, and C. Gottschalk, “Truncated satratoxin gene clusters in selected isolates of the atranone chemotype of Stachybotrys chartarum (Ehrenb.) S. Hughes,” <i>Mycotoxin Research</i>, vol. 36, no. 1, pp. 83–91, 2019, doi: <a href=\"https://doi.org/10.1007/s12550-019-00371-x\">10.1007/s12550-019-00371-x</a>.","bjps":"<b>Ulrich S <i>et al.</i></b> (2019) Truncated Satratoxin Gene Clusters in Selected Isolates of the Atranone Chemotype of Stachybotrys Chartarum (Ehrenb.) S. Hughes. <i>Mycotoxin Research</i> <b>36</b>, 83–91.","apa":"Ulrich, S., Niessen, L., Ekruth, J., Schäfer, C., Kaltner, F., &#38; Gottschalk, C. (2019). Truncated satratoxin gene clusters in selected isolates of the atranone chemotype of Stachybotrys chartarum (Ehrenb.) S. Hughes. <i>Mycotoxin Research</i>, <i>36</i>(1), 83–91. <a href=\"https://doi.org/10.1007/s12550-019-00371-x\">https://doi.org/10.1007/s12550-019-00371-x</a>","van":"Ulrich S, Niessen L, Ekruth J, Schäfer C, Kaltner F, Gottschalk C. Truncated satratoxin gene clusters in selected isolates of the atranone chemotype of Stachybotrys chartarum (Ehrenb.) S. Hughes. Mycotoxin Research. 2019;36(1):83–91.","mla":"Ulrich, Sebastian, et al. “Truncated Satratoxin Gene Clusters in Selected Isolates of the Atranone Chemotype of Stachybotrys Chartarum (Ehrenb.) S. Hughes.” <i>Mycotoxin Research</i>, vol. 36, no. 1, 2019, pp. 83–91, <a href=\"https://doi.org/10.1007/s12550-019-00371-x\">https://doi.org/10.1007/s12550-019-00371-x</a>.","short":"S. Ulrich, L. Niessen, J. Ekruth, C. Schäfer, F. Kaltner, C. Gottschalk, Mycotoxin Research 36 (2019) 83–91.","havard":"S. Ulrich, L. Niessen, J. Ekruth, C. Schäfer, F. Kaltner, C. Gottschalk, Truncated satratoxin gene clusters in selected isolates of the atranone chemotype of Stachybotrys chartarum (Ehrenb.) S. Hughes, Mycotoxin Research. 36 (2019) 83–91.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Ulrich, Sebastian</span> ; <span style=\"font-variant:small-caps;\">Niessen, Ludwig</span> ; <span style=\"font-variant:small-caps;\">Ekruth, Julia</span> ; <span style=\"font-variant:small-caps;\">Schäfer, Cornelius</span> ; <span style=\"font-variant:small-caps;\">Kaltner, Florian</span> ; <span style=\"font-variant:small-caps;\">Gottschalk, Christoph</span>: Truncated satratoxin gene clusters in selected isolates of the atranone chemotype of Stachybotrys chartarum (Ehrenb.) S. Hughes. In: <i>Mycotoxin Research</i> Bd. 36. Berlin ; Heidelberg, Springer (2019), Nr. 1, S. 83–91"},"page":"83-91","publication_identifier":{"issn":["0178-7888"],"eissn":["1867-1632"]},"_id":"12966","keyword":["Acetyltransferases","Chlamydomonas reinhardtii","Fungal Genes","Fungal genetics","Fungal genomics","Saccharomyces cerevisiae"]}]