[{"series_title":"Methods in Molecular Biology","publication":"Animal Cell Biotechnology - Methods and Protocols","_id":"2397","publication_identifier":{"issn":["1064-3745"],"isbn":["978-1-07-160190-7"],"eisbn":["978-1-07-160191-4"]},"intvolume":"      2095","author":[{"full_name":"Hernández Rodríguez, Tanja","last_name":"Hernández Rodríguez","first_name":"Tanja"},{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"}],"language":[{"iso":"eng"}],"date_created":"2020-05-19T15:11:00Z","volume":2095,"publication_status":"published","place":"Berlin, Heidelberg, New York","citation":{"van":"Hernández Rodríguez T, Frahm B. Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In: Pörtner R, editor. Animal Cell Biotechnology - Methods and Protocols. Berlin, Heidelberg, New York: Springer; 2020. p. 251–67. (Methods in Molecular Biology; vol. 2095).","ama":"Hernández Rodríguez T, Frahm B. Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In: Pörtner R, ed. <i>Animal Cell Biotechnology - Methods and Protocols</i>. Vol 2095. Methods in Molecular Biology. Berlin, Heidelberg, New York: Springer; 2020:251-267. doi:<a href=\"https://doi.org/10.1007/978-1-0716-0191-4_14\">10.1007/978-1-0716-0191-4_14</a>","ieee":"T. Hernández Rodríguez and B. Frahm, “Design, Optimization and Adaptive Control of Cell Culture Seed Trains,” in <i>Animal Cell Biotechnology - Methods and Protocols</i>, vol. 2095, R. Pörtner, Ed. Berlin, Heidelberg, New York: Springer, 2020, pp. 251–267.","chicago":"Hernández Rodríguez, Tanja, and Björn Frahm. “Design, Optimization and Adaptive Control of Cell Culture Seed Trains.” In <i>Animal Cell Biotechnology - Methods and Protocols</i>, edited by Ralf Pörtner, 2095:251–67. Methods in Molecular Biology. Berlin, Heidelberg, New York: Springer, 2020. <a href=\"https://doi.org/10.1007/978-1-0716-0191-4_14\">https://doi.org/10.1007/978-1-0716-0191-4_14</a>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodríguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In: <span style=\"font-variant:small-caps;\">Pörtner, R.</span> (Hrsg.): <i>Animal Cell Biotechnology - Methods and Protocols</i>, <i>Methods in Molecular Biology</i>. Bd. 2095. Berlin, Heidelberg, New York : Springer, 2020, S. 251–267","bjps":"<b>Hernández Rodríguez T and Frahm B</b> (2020) Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In Pörtner R (ed.), <i>Animal Cell Biotechnology - Methods and Protocols</i>, vol. 2095. Berlin, Heidelberg, New York: Springer, pp. 251–267.","havard":"T. Hernández Rodríguez, B. Frahm, Design, Optimization and Adaptive Control of Cell Culture Seed Trains, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, Springer, Berlin, Heidelberg, New York, 2020: pp. 251–267.","chicago-de":"Hernández Rodríguez, Tanja und Björn Frahm. 2020. Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In: <i>Animal Cell Biotechnology - Methods and Protocols</i>, hg. von Ralf Pörtner, 2095:251–267. Methods in Molecular Biology. Berlin, Heidelberg, New York: Springer. doi:<a href=\"https://doi.org/10.1007/978-1-0716-0191-4_14,\">10.1007/978-1-0716-0191-4_14,</a> .","ufg":"<b>Hernández Rodríguez, Tanja/Frahm, Björn (2020)</b>: Design, Optimization and Adaptive Control of Cell Culture Seed Trains, in: Ralf Pörtner (Hg.): <i>Animal Cell Biotechnology - Methods and Protocols</i> (=<i>Methods in Molecular Biology 2095</i>), Berlin, Heidelberg, New York, S. 251–267.","mla":"Hernández Rodríguez, Tanja, and Björn Frahm. “Design, Optimization and Adaptive Control of Cell Culture Seed Trains.” <i>Animal Cell Biotechnology - Methods and Protocols</i>, edited by Ralf Pörtner, vol. 2095, Springer, 2020, pp. 251–67, doi:<a href=\"https://doi.org/10.1007/978-1-0716-0191-4_14\">10.1007/978-1-0716-0191-4_14</a>.","apa":"Hernández Rodríguez, T., &#38; Frahm, B. (2020). Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In R. Pörtner (Ed.), <i>Animal Cell Biotechnology - Methods and Protocols</i> (Vol. 2095, pp. 251–267). Berlin, Heidelberg, New York: Springer. <a href=\"https://doi.org/10.1007/978-1-0716-0191-4_14\">https://doi.org/10.1007/978-1-0716-0191-4_14</a>","short":"T. Hernández Rodríguez, B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, Springer, Berlin, Heidelberg, New York, 2020, pp. 251–267."},"title":"Design, Optimization and Adaptive Control of Cell Culture Seed Trains","department":[{"_id":"DEP4021"}],"user_id":"45666","year":2020,"status":"public","page":"251-267","type":"book_chapter","publisher":"Springer","editor":[{"first_name":"Ralf","last_name":"Pörtner","full_name":"Pörtner, Ralf"}],"quality_controlled":"1","doi":"10.1007/978-1-0716-0191-4_14","date_updated":"2023-03-15T13:49:39Z"},{"publication_identifier":{"eisbn":["978-1-07-160191-4"],"isbn":["978-1-07-160190-7"],"issn":["1064-3745"]},"intvolume":"      2095","author":[{"full_name":"Deppe, S.","last_name":"Deppe","first_name":"S."},{"id":"45666","last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn"},{"first_name":"V. C.","last_name":"Hass","full_name":"Hass, V. C."},{"full_name":"Hernández Rodríguez, T.","last_name":"Hernández Rodríguez","first_name":"T."},{"first_name":"K. B.","full_name":"Kuchemüller, K. B.","last_name":"Kuchemüller"},{"first_name":"J.","full_name":"Möller, J.","last_name":"Möller"},{"first_name":"R.","last_name":"Pörtner","full_name":"Pörtner, R."}],"language":[{"iso":"eng"}],"date_created":"2020-05-19T15:11:00Z","volume":2095,"publication_status":"published","place":"Berlin ; Heidelberg ; New York","citation":{"ieee":"S. Deppe <i>et al.</i>, “Estimation of Process Model Parameters,” in <i>Animal Cell Biotechnology: Methods and Protocols</i>, vol. 2095, R. Pörtner, Ed. Berlin ; Heidelberg ; New York: Springer, 2020, pp. 213–234.","ama":"Deppe S, Frahm B, Hass VC, et al. Estimation of Process Model Parameters. In: Pörtner R, ed. <i>Animal Cell Biotechnology: Methods and Protocols</i>. Vol 2095. Methods in Molecular Biology. Berlin ; Heidelberg ; New York: Springer; 2020:213-234. doi:<a href=\"https://doi.org/10.1007/978-1-0716-0191-4_12\">10.1007/978-1-0716-0191-4_12</a>","van":"Deppe S, Frahm B, Hass VC, Hernández Rodríguez T, Kuchemüller KB, Möller J, et al. Estimation of Process Model Parameters. In: Pörtner R, editor. Animal Cell Biotechnology: Methods and Protocols. Berlin ; Heidelberg ; New York: Springer; 2020. p. 213–34. (Methods in Molecular Biology; vol. 2095).","din1505-2-1":"<span style=\"font-variant:small-caps;\">Deppe, S.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Hass, V. C.</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodríguez, T.</span> ; <span style=\"font-variant:small-caps;\">Kuchemüller, K. B.</span> ; <span style=\"font-variant:small-caps;\">Möller, J.</span> ; <span style=\"font-variant:small-caps;\">Pörtner, R.</span>: Estimation of Process Model Parameters. In: <span style=\"font-variant:small-caps;\">Pörtner, R.</span> (Hrsg.): <i>Animal Cell Biotechnology: Methods and Protocols</i>, <i>Methods in Molecular Biology</i>. Bd. 2095. Berlin ; Heidelberg ; New York : Springer, 2020, S. 213–234","bjps":"<b>Deppe S <i>et al.</i></b> (2020) Estimation of Process Model Parameters. In Pörtner Ralf (ed.), <i>Animal Cell Biotechnology: Methods and Protocols</i>, vol. 2095. Berlin ; Heidelberg ; New York: Springer, pp. 213–234.","chicago":"Deppe, S., Björn Frahm, V. C. Hass, T. Hernández Rodríguez, K. B. Kuchemüller, J. Möller, and R. Pörtner. “Estimation of Process Model Parameters.” In <i>Animal Cell Biotechnology: Methods and Protocols</i>, edited by Ralf Pörtner, 2095:213–34. Methods in Molecular Biology. Berlin ; Heidelberg ; New York: Springer, 2020. <a href=\"https://doi.org/10.1007/978-1-0716-0191-4_12\">https://doi.org/10.1007/978-1-0716-0191-4_12</a>.","havard":"S. Deppe, B. Frahm, V.C. Hass, T. Hernández Rodríguez, K.B. Kuchemüller, J. Möller, R. Pörtner, Estimation of Process Model Parameters, in: R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols, Springer, Berlin ; Heidelberg ; New York, 2020: pp. 213–234.","mla":"Deppe, S., et al. “Estimation of Process Model Parameters.” <i>Animal Cell Biotechnology: Methods and Protocols</i>, edited by Ralf Pörtner, vol. 2095, Springer, 2020, pp. 213–34, doi:<a href=\"https://doi.org/10.1007/978-1-0716-0191-4_12\">10.1007/978-1-0716-0191-4_12</a>.","apa":"Deppe, S., Frahm, B., Hass, V. C., Hernández Rodríguez, T., Kuchemüller, K. B., Möller, J., &#38; Pörtner, R. (2020). Estimation of Process Model Parameters. In R. Pörtner (Ed.), <i>Animal Cell Biotechnology: Methods and Protocols</i> (Vol. 2095, pp. 213–234). Berlin ; Heidelberg ; New York: Springer. <a href=\"https://doi.org/10.1007/978-1-0716-0191-4_12\">https://doi.org/10.1007/978-1-0716-0191-4_12</a>","short":"S. Deppe, B. Frahm, V.C. Hass, T. Hernández Rodríguez, K.B. Kuchemüller, J. Möller, R. Pörtner, in: R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols, Springer, Berlin ; Heidelberg ; New York, 2020, pp. 213–234.","chicago-de":"Deppe, S., Björn Frahm, V. C. Hass, T. Hernández Rodríguez, K. B. Kuchemüller, J. Möller und R. Pörtner. 2020. Estimation of Process Model Parameters. In: <i>Animal Cell Biotechnology: Methods and Protocols</i>, hg. von Ralf Pörtner, 2095:213–234. Methods in Molecular Biology. Berlin ; Heidelberg ; New York: Springer. doi:<a href=\"https://doi.org/10.1007/978-1-0716-0191-4_12,\">10.1007/978-1-0716-0191-4_12,</a> .","ufg":"<b>Deppe, S. et. al. (2020)</b>: Estimation of Process Model Parameters, in: Ralf Pörtner (Hg.): <i>Animal Cell Biotechnology: Methods and Protocols</i> (=<i>Methods in Molecular Biology 2095</i>), Berlin ; Heidelberg ; New York, S. 213–234."},"title":"Estimation of Process Model Parameters","series_title":"Methods in Molecular Biology","publication":"Animal Cell Biotechnology: Methods and Protocols","_id":"2399","type":"book_chapter","publisher":"Springer","editor":[{"full_name":"Pörtner, Ralf","last_name":"Pörtner","first_name":"Ralf"}],"quality_controlled":"1","doi":"10.1007/978-1-0716-0191-4_12","date_updated":"2023-03-15T13:49:39Z","department":[{"_id":"DEP4021"}],"user_id":"45666","year":2020,"status":"public","page":"213-234"},{"date_created":"2020-05-19T14:45:43Z","language":[{"iso":"eng"}],"publication_status":"published","volume":1104,"place":"Totowa, NJ","citation":{"short":"B. Frahm, in: Animal Cell Biotechnology, Humana Press, Totowa, NJ, 2013, pp. 355–367.","mla":"Frahm, Björn. “Seed Train Optimization for Cell Culture.” <i>Animal Cell Biotechnology</i>, vol. 1104, Humana Press, 2013, pp. 355–67, doi:<a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">10.1007/978-1-62703-733-4_22</a>.","apa":"Frahm, B. (2013). Seed Train Optimization for Cell Culture. In <i>Animal Cell Biotechnology</i> (Vol. 1104, pp. 355–367). Totowa, NJ: Humana Press. <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">https://doi.org/10.1007/978-1-62703-733-4_22</a>","ufg":"<b>Frahm, Björn (2013)</b>: Seed Train Optimization for Cell Culture, in: <i>Animal Cell Biotechnology</i> (=<i>Methods in Molecular Biology  1104</i>), Totowa, NJ, S. 355–367.","chicago-de":"Frahm, Björn. 2013. Seed Train Optimization for Cell Culture. In: <i>Animal Cell Biotechnology</i>, 1104:355–367. Methods in Molecular Biology . Totowa, NJ: Humana Press. doi:<a href=\"https://doi.org/10.1007/978-1-62703-733-4_22,\">10.1007/978-1-62703-733-4_22,</a> .","havard":"B. Frahm, Seed Train Optimization for Cell Culture, in: Animal Cell Biotechnology, Humana Press, Totowa, NJ, 2013: pp. 355–367.","bjps":"<b>Frahm B</b> (2013) Seed Train Optimization for Cell Culture. <i>Animal Cell Biotechnology</i>, vol. 1104. Totowa, NJ: Humana Press, pp. 355–367.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Seed Train Optimization for Cell Culture. In: <i>Animal Cell Biotechnology</i>, <i>Methods in Molecular Biology </i>. Bd. 1104. Totowa, NJ : Humana Press, 2013, S. 355–367","chicago":"Frahm, Björn. “Seed Train Optimization for Cell Culture.” In <i>Animal Cell Biotechnology</i>, 1104:355–67. Methods in Molecular Biology . Totowa, NJ: Humana Press, 2013. <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">https://doi.org/10.1007/978-1-62703-733-4_22</a>.","ieee":"B. Frahm, “Seed Train Optimization for Cell Culture,” in <i>Animal Cell Biotechnology</i>, vol. 1104, Totowa, NJ: Humana Press, 2013, pp. 355–367.","ama":"Frahm B. Seed Train Optimization for Cell Culture. In: <i>Animal Cell Biotechnology</i>. Vol 1104. Methods in Molecular Biology . Totowa, NJ: Humana Press; 2013:355-367. doi:<a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">10.1007/978-1-62703-733-4_22</a>","van":"Frahm B. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology. Totowa, NJ: Humana Press; 2013. p. 355–67. (Methods in Molecular Biology ; vol. 1104)."},"publication_identifier":{"isbn":["9781627037327"],"issn":["1064-3745","1940-6029"],"eisbn":["9781627037334"]},"intvolume":"      1104","author":[{"last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn"}],"title":"Seed Train Optimization for Cell Culture","publication":"Animal Cell Biotechnology","series_title":"Methods in Molecular Biology ","_id":"2394","publisher":"Humana Press","type":"book_chapter","date_updated":"2023-03-15T13:49:39Z","doi":"10.1007/978-1-62703-733-4_22","status":"public","department":[{"_id":"DEP4021"}],"user_id":"74004","year":2013,"page":"355-367","abstract":[{"text":"For the production of biopharmaceuticals a seed train is required to generate an adequate number of cells for inoculation of the production bioreactor. This seed train is time- and cost-intensive but offers potential for optimization. A method and a protocol are described for the seed train mapping, directed modeling without major effort, and its optimization regarding selected optimization criteria such as optimal points in time for cell passaging. Furthermore, the method can also be applied for the set-up of a new seed train, for example for a new cell line. Although the chapter is directed towards suspension cell lines, the method is also generally applicable, e.g. for adherent cell lines.","lang":"eng"}],"keyword":["Seed train Optimization Modeling Prediction Space-Time-Yield (STY) Systems approach Bioinformatics Computational biotechnology Suspension Production"]},{"abstract":[{"text":"For the production of biopharmaceuticals a seed train is required to generate an adequate number of cells for inoculation of the production bioreactor. This seed train is time- and cost-intensive but offers potential for optimization. A method and a protocol are described for the seed train mapping, directed modeling without major effort, and its optimization regarding selected optimization criteria such as optimal points in time for cell passaging. Furthermore, the method can also be applied for the set-up of a new seed train, for example for a new cell line. Although the chapter is directed towards suspension cell lines, the method is also generally applicable, e.g. for adherent cell lines.","lang":"eng"}],"page":"355–367","keyword":["Seed train","Optimization","Modeling","Prediction","Space-Time-Yield (STY)","Systems approach","Bioinformatics","Computational biotechnology","Suspension","Production"],"status":"public","year":"2013","user_id":"83781","department":[{"_id":"DEP4000"}],"doi":"10.1007/978-1-62703-733-4_22","date_updated":"2023-08-16T06:41:21Z","editor":[{"full_name":"Pörtner, Ralf","last_name":"Pörtner","first_name":"Ralf"}],"publisher":"Humana Press","type":"book_chapter","_id":"10214","publication":"Animal Cell Biotechnology - Methods and Protocols","edition":"3","series_title":"Methods in Molecular Biology","title":"Seed Train Optimization for Cell Culture","citation":{"ama":"Frahm B. Seed Train Optimization for Cell Culture. In: Pörtner R, ed. <i>Animal Cell Biotechnology - Methods and Protocols</i>. Vol 1104. 3rd ed. Methods in Molecular Biology. Humana Press; 2013:355-367. doi:<a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">10.1007/978-1-62703-733-4_22</a>","van":"Frahm B. Seed Train Optimization for Cell Culture. In: Pörtner R, editor. Animal Cell Biotechnology - Methods and Protocols. 3rd ed. Totowa, NJ: Humana Press; 2013. p. 355–67. (Methods in Molecular Biology; vol. 1104).","havard":"B. Frahm, Seed Train Optimization for Cell Culture, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013: pp. 355–367.","ieee":"B. Frahm, “Seed Train Optimization for Cell Culture,” in <i>Animal Cell Biotechnology - Methods and Protocols</i>, 3rd ed., vol. 1104, R. Pörtner, Ed. Totowa, NJ: Humana Press, 2013, pp. 355–367. doi: <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">10.1007/978-1-62703-733-4_22</a>.","chicago":"Frahm, Björn. “Seed Train Optimization for Cell Culture.” In <i>Animal Cell Biotechnology - Methods and Protocols</i>, edited by Ralf Pörtner, 3rd ed., 1104:355–67. Methods in Molecular Biology. Totowa, NJ: Humana Press, 2013. <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">https://doi.org/10.1007/978-1-62703-733-4_22</a>.","chicago-de":"Frahm, Björn. 2013. Seed Train Optimization for Cell Culture. In: <i>Animal Cell Biotechnology - Methods and Protocols</i>, hg. von Ralf Pörtner, 1104:355–367. 3. Aufl. Methods in Molecular Biology. Totowa, NJ: Humana Press. doi:<a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">10.1007/978-1-62703-733-4_22</a>, .","ufg":"<b>Frahm, Björn</b>: Seed Train Optimization for Cell Culture, in: <i>Pörtner, Ralf (Hg.)</i>: Animal Cell Biotechnology - Methods and Protocols, Bd. 1104, Totowa, NJ <sup>3</sup>2013 (Methods in Molecular Biology),  S. 355–367.","mla":"Frahm, Björn. “Seed Train Optimization for Cell Culture.” <i>Animal Cell Biotechnology - Methods and Protocols</i>, edited by Ralf Pörtner, 3rd ed., vol. 1104, Humana Press, 2013, pp. 355–67, <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">https://doi.org/10.1007/978-1-62703-733-4_22</a>.","apa":"Frahm, B. (2013). Seed Train Optimization for Cell Culture. In R. Pörtner (Ed.), <i>Animal Cell Biotechnology - Methods and Protocols</i> (3rd ed., Vol. 1104, pp. 355–367). Humana Press. <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">https://doi.org/10.1007/978-1-62703-733-4_22</a>","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Seed Train Optimization for Cell Culture. In: <span style=\"font-variant:small-caps;\">Pörtner, R.</span> (Hrsg.): <i>Animal Cell Biotechnology - Methods and Protocols</i>, <i>Methods in Molecular Biology</i>. Bd. 1104. 3. Aufl. Totowa, NJ : Humana Press, 2013, S. 355–367","bjps":"<b>Frahm B</b> (2013) Seed Train Optimization for Cell Culture. In Pörtner R (ed.), <i>Animal Cell Biotechnology - Methods and Protocols</i>, 3rd ed., vol. 1104. Totowa, NJ: Humana Press, pp. 355–367.","short":"B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013, pp. 355–367."},"place":"Totowa, NJ","volume":1104,"publication_status":"published","date_created":"2023-08-14T17:50:56Z","language":[{"iso":"eng"}],"author":[{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"}],"intvolume":"      1104","publication_identifier":{"isbn":["978-1-62703-732-7"],"issn":["1064-3745"],"eissn":["1940-6029"],"eisbn":["978-1-62703-733-4"]}}]