---
_id: '11733'
abstract:
- lang: eng
  text: "Abstract\r\nObjective: In the last years, several projects promote the secondary
    use of routine healthcare data based on electronic health record (EHR) data. In
    multicenter studies, dedicated pseudonymization services are applied for unified
    pseudonym handling. Healthcare, clinical research and pseudonymization systems
    are generally disconnected. Hence, the aim of this research work is to integrate
    these applications and to evaluate the workflow of clinical research.\r\n\r\nMethods:
    We analyzed and identified technical solutions for legislation compliant automatic
    pseudonym generation and for the integration into EHR as well as electronic data
    capture (EDC) systems. The Mainzelliste was used as pseudonymization service,
    which is available as open source solution and compliant with the data privacy
    concept in Germany. Subject of the integration was the local EHR and an in-house
    developed EDC system. A time and motion study was conducted to evaluate the effects
    on the workflow.\r\n\r\nResults: Integration of EHR, pseudonymization service
    and EDC systems is technically feasible and leads to a less fragmented usage of
    all applications. Generated pseudonyms are obtained from the service hosted at
    a trusted third party and can now be used in the EDC as well as in the EHR system
    for direct access and re-identification. The evaluation of 90 registration iterations
    shows that the time for documentation has been significantly reduced in average
    by 39.6 s (56.3%) from 71 ± 8 s to 31 ± 5 s per registered study patient.\r\n\r\nConclusions:
    By incorporating EHR, EDC and pseudonymization systems, it is now feasible to
    support multicenter studies and registers out of an integrated system landscape
    within a hospital. Optimizing the workflow of patient registration for clinical
    research allows reduction of double data entry and transcription errors as well
    as a seamless transition from clinical routine to research data collection.\r\n\r\nKeywords:
    Data management; Electronic data capture; Health information systems; Pseudonymization;
    Workflow optimization."
author:
- first_name: Philipp
  full_name: Bruland, Philipp
  id: '75847'
  last_name: Bruland
  orcid: 0000-0001-6939-7630
- first_name: Justin
  full_name: Doods, Justin
  last_name: Doods
- first_name: Tobias
  full_name: Brix, Tobias
  last_name: Brix
- first_name: Martin
  full_name: Dugas, Martin
  last_name: Dugas
- first_name: Michael
  full_name: Storck, Michael
  last_name: Storck
citation:
  ama: 'Bruland P, Doods J, Brix T, Dugas M, Storck M. Connecting healthcare and clinical
    research: Workflow optimizations through seamless integration of EHR, pseudonymization
    services and EDC systems. <i>International Journal of Medical Informatics</i>.
    2018;119:103-108. doi:<a href="https://doi.org/10.1016/j.ijmedinf.2018.09.007">10.1016/j.ijmedinf.2018.09.007</a>'
  apa: 'Bruland, P., Doods, J., Brix, T., Dugas, M., &#38; Storck, M. (2018). Connecting
    healthcare and clinical research: Workflow optimizations through seamless integration
    of EHR, pseudonymization services and EDC systems. <i>International Journal of
    Medical Informatics</i>, <i>119</i>, 103–108. <a href="https://doi.org/10.1016/j.ijmedinf.2018.09.007">https://doi.org/10.1016/j.ijmedinf.2018.09.007</a>'
  bjps: '<b>Bruland P <i>et al.</i></b> (2018) Connecting Healthcare and Clinical
    Research: Workflow Optimizations through Seamless Integration of EHR, Pseudonymization
    Services and EDC Systems. <i>International Journal of Medical Informatics</i>
    <b>119</b>, 103–108.'
  chicago: 'Bruland, Philipp, Justin Doods, Tobias Brix, Martin Dugas, and Michael
    Storck. “Connecting Healthcare and Clinical Research: Workflow Optimizations through
    Seamless Integration of EHR, Pseudonymization Services and EDC Systems.” <i>International
    Journal of Medical Informatics</i> 119 (2018): 103–8. <a href="https://doi.org/10.1016/j.ijmedinf.2018.09.007">https://doi.org/10.1016/j.ijmedinf.2018.09.007</a>.'
  chicago-de: 'Bruland, Philipp, Justin Doods, Tobias Brix, Martin Dugas und Michael
    Storck. 2018. Connecting healthcare and clinical research: Workflow optimizations
    through seamless integration of EHR, pseudonymization services and EDC systems.
    <i>International Journal of Medical Informatics</i> 119: 103–108. doi:<a href="https://doi.org/10.1016/j.ijmedinf.2018.09.007">10.1016/j.ijmedinf.2018.09.007</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Bruland, Philipp</span> ; <span
    style="font-variant:small-caps;">Doods, Justin</span> ; <span style="font-variant:small-caps;">Brix,
    Tobias</span> ; <span style="font-variant:small-caps;">Dugas, Martin</span> ;
    <span style="font-variant:small-caps;">Storck, Michael</span>: Connecting healthcare
    and clinical research: Workflow optimizations through seamless integration of
    EHR, pseudonymization services and EDC systems. In: <i>International Journal of
    Medical Informatics</i> Bd. 119, Elsevier BV (2018), S. 103–108'
  havard: 'P. Bruland, J. Doods, T. Brix, M. Dugas, M. Storck, Connecting healthcare
    and clinical research: Workflow optimizations through seamless integration of
    EHR, pseudonymization services and EDC systems, International Journal of Medical
    Informatics. 119 (2018) 103–108.'
  ieee: 'P. Bruland, J. Doods, T. Brix, M. Dugas, and M. Storck, “Connecting healthcare
    and clinical research: Workflow optimizations through seamless integration of
    EHR, pseudonymization services and EDC systems,” <i>International Journal of Medical
    Informatics</i>, vol. 119, pp. 103–108, 2018, doi: <a href="https://doi.org/10.1016/j.ijmedinf.2018.09.007">10.1016/j.ijmedinf.2018.09.007</a>.'
  mla: 'Bruland, Philipp, et al. “Connecting Healthcare and Clinical Research: Workflow
    Optimizations through Seamless Integration of EHR, Pseudonymization Services and
    EDC Systems.” <i>International Journal of Medical Informatics</i>, vol. 119, 2018,
    pp. 103–08, <a href="https://doi.org/10.1016/j.ijmedinf.2018.09.007">https://doi.org/10.1016/j.ijmedinf.2018.09.007</a>.'
  short: P. Bruland, J. Doods, T. Brix, M. Dugas, M. Storck, International Journal
    of Medical Informatics 119 (2018) 103–108.
  ufg: '<b>Bruland, Philipp u. a.</b>: Connecting healthcare and clinical research:
    Workflow optimizations through seamless integration of EHR, pseudonymization services
    and EDC systems, in: <i>International Journal of Medical Informatics</i> 119 (2018), 
    S. 103–108.'
  van: 'Bruland P, Doods J, Brix T, Dugas M, Storck M. Connecting healthcare and clinical
    research: Workflow optimizations through seamless integration of EHR, pseudonymization
    services and EDC systems. International Journal of Medical Informatics. 2018;119:103–8.'
date_created: 2024-07-18T12:13:59Z
date_updated: 2024-08-15T12:54:39Z
department:
- _id: DEP5024
doi: 10.1016/j.ijmedinf.2018.09.007
extern: '1'
intvolume: '       119'
language:
- iso: eng
page: 103-108
publication: International Journal of Medical Informatics
publication_identifier:
  issn:
  - 1386-5056
publication_status: published
publisher: Elsevier BV
status: public
title: 'Connecting healthcare and clinical research: Workflow optimizations through
  seamless integration of EHR, pseudonymization services and EDC systems'
type: scientific_journal_article
user_id: '83781'
volume: 119
year: '2018'
...
---
_id: '11588'
article_type: original
author:
- first_name: Philipp
  full_name: Bruland, Philipp
  last_name: Bruland
- first_name: Christian
  full_name: Forster, Christian
  last_name: Forster
- first_name: Bernhard
  full_name: Breil, Bernhard
  last_name: Breil
- first_name: Sonja
  full_name: Ständer, Sonja
  last_name: Ständer
- first_name: Martin
  full_name: Dugas, Martin
  last_name: Dugas
- first_name: Fleur
  full_name: Fritz, Fleur
  last_name: Fritz
citation:
  ama: Bruland P, Forster C, Breil B, Ständer S, Dugas M, Fritz F. Does single-source
    create an added value? Evaluating the impact of introducing x4T into the clinical
    routine on workflow modifications, data quality and cost–benefit. <i>International
    Journal of Medical Informatics</i>. 2014;83(12):915-928. doi:<a href="https://doi.org/10.1016/j.ijmedinf.2014.08.007">10.1016/j.ijmedinf.2014.08.007</a>
  apa: Bruland, P., Forster, C., Breil, B., Ständer, S., Dugas, M., &#38; Fritz, F.
    (2014). Does single-source create an added value? Evaluating the impact of introducing
    x4T into the clinical routine on workflow modifications, data quality and cost–benefit.
    <i>International Journal of Medical Informatics</i>, <i>83</i>(12), 915–928. <a
    href="https://doi.org/10.1016/j.ijmedinf.2014.08.007">https://doi.org/10.1016/j.ijmedinf.2014.08.007</a>
  bjps: <b>Bruland P <i>et al.</i></b> (2014) Does Single-Source Create an Added Value?
    Evaluating the Impact of Introducing X4T into the Clinical Routine on Workflow
    Modifications, Data Quality and Cost–Benefit. <i>International Journal of Medical
    Informatics</i> <b>83</b>, 915–928.
  chicago: 'Bruland, Philipp, Christian Forster, Bernhard Breil, Sonja Ständer, Martin
    Dugas, and Fleur Fritz. “Does Single-Source Create an Added Value? Evaluating
    the Impact of Introducing X4T into the Clinical Routine on Workflow Modifications,
    Data Quality and Cost–Benefit.” <i>International Journal of Medical Informatics</i>
    83, no. 12 (2014): 915–28. <a href="https://doi.org/10.1016/j.ijmedinf.2014.08.007">https://doi.org/10.1016/j.ijmedinf.2014.08.007</a>.'
  chicago-de: 'Bruland, Philipp, Christian Forster, Bernhard Breil, Sonja Ständer,
    Martin Dugas und Fleur Fritz. 2014. Does single-source create an added value?
    Evaluating the impact of introducing x4T into the clinical routine on workflow
    modifications, data quality and cost–benefit. <i>International Journal of Medical
    Informatics</i> 83, Nr. 12: 915–928. doi:<a href="https://doi.org/10.1016/j.ijmedinf.2014.08.007">10.1016/j.ijmedinf.2014.08.007</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Bruland, Philipp</span> ; <span
    style="font-variant:small-caps;">Forster, Christian</span> ; <span style="font-variant:small-caps;">Breil,
    Bernhard</span> ; <span style="font-variant:small-caps;">Ständer, Sonja</span>
    ; <span style="font-variant:small-caps;">Dugas, Martin</span> ; <span style="font-variant:small-caps;">Fritz,
    Fleur</span>: Does single-source create an added value? Evaluating the impact
    of introducing x4T into the clinical routine on workflow modifications, data quality
    and cost–benefit. In: <i>International Journal of Medical Informatics</i> Bd.
    83. Amsterdam, Elsevier BV (2014), Nr. 12, S. 915–928'
  havard: P. Bruland, C. Forster, B. Breil, S. Ständer, M. Dugas, F. Fritz, Does single-source
    create an added value? Evaluating the impact of introducing x4T into the clinical
    routine on workflow modifications, data quality and cost–benefit, International
    Journal of Medical Informatics. 83 (2014) 915–928.
  ieee: 'P. Bruland, C. Forster, B. Breil, S. Ständer, M. Dugas, and F. Fritz, “Does
    single-source create an added value? Evaluating the impact of introducing x4T
    into the clinical routine on workflow modifications, data quality and cost–benefit,”
    <i>International Journal of Medical Informatics</i>, vol. 83, no. 12, pp. 915–928,
    2014, doi: <a href="https://doi.org/10.1016/j.ijmedinf.2014.08.007">10.1016/j.ijmedinf.2014.08.007</a>.'
  mla: Bruland, Philipp, et al. “Does Single-Source Create an Added Value? Evaluating
    the Impact of Introducing X4T into the Clinical Routine on Workflow Modifications,
    Data Quality and Cost–Benefit.” <i>International Journal of Medical Informatics</i>,
    vol. 83, no. 12, 2014, pp. 915–28, <a href="https://doi.org/10.1016/j.ijmedinf.2014.08.007">https://doi.org/10.1016/j.ijmedinf.2014.08.007</a>.
  short: P. Bruland, C. Forster, B. Breil, S. Ständer, M. Dugas, F. Fritz, International
    Journal of Medical Informatics 83 (2014) 915–928.
  ufg: '<b>Bruland, Philipp u. a.</b>: Does single-source create an added value? Evaluating
    the impact of introducing x4T into the clinical routine on workflow modifications,
    data quality and cost–benefit, in: <i>International Journal of Medical Informatics</i>
    83 (2014), H. 12,  S. 915–928.'
  van: Bruland P, Forster C, Breil B, Ständer S, Dugas M, Fritz F. Does single-source
    create an added value? Evaluating the impact of introducing x4T into the clinical
    routine on workflow modifications, data quality and cost–benefit. International
    Journal of Medical Informatics. 2014;83(12):915–28.
date_created: 2024-06-24T07:38:45Z
date_updated: 2024-07-17T13:30:11Z
department:
- _id: DEP5024
doi: 10.1016/j.ijmedinf.2014.08.007
extern: '1'
intvolume: '        83'
issue: '12'
language:
- iso: eng
page: 915-928
place: Amsterdam
publication: International Journal of Medical Informatics
publication_identifier:
  eissn:
  - 1872-8243
  issn:
  - 1386-5056
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
status: public
title: Does single-source create an added value? Evaluating the impact of introducing
  x4T into the clinical routine on workflow modifications, data quality and cost–benefit
type: scientific_journal_article
user_id: '83781'
volume: 83
year: '2014'
...