---
_id: '12781'
abstract:
- lang: eng
text: Roller compaction/dry granulation (RC/DG) is a key process in pharmaceutical
manufacturing for improving powder flowability, density, and segregation resistance.
Advanced statistical modeling was used to optimize RC/DG process parameters and
subsequently binder compositions by employing process and mixture design experiments.
The authors used microcrystalline cellulose (MCC), silicified MCC (SMCC), and
dicalcium phosphate (DCP) as filler-binder examples in RC/DG experiments. Granule
and tablet properties, including flowability, bulk and tapped densities, as well
as resistance to crushing, were analyzed using compendial methods. The process
design experiments confirmed that RC/DG reduces manufacturability compared to
direct compression. Optimal processing conditions, balancing sufficient tablet
strengths and granule formation, were identified to be between 20 (SCF * ϑ) [kN/cm]
and ∼ 60 (SCF * ϑ) [kN/cm]. Thereby (ϑ) is defined as the screw-to-roll speed
ratio and (SFC) as the specific compaction force. Mixture design experiments revealed
optimal mixtures balancing SMCC, MCC, and DCP to achieve desired properties like
low angle of repose, high bulk density, and strong tablets. These findings provide
guidance for selecting formulations and process parameters in RC/DG applications.
The derived ‘SCF * ϑ’- factor was found to effectively describe the granulation
intensity. A superimposed mixture design model based on precise target values
of the parameters bulk density, flow properties, and breaking force allowed identification
of the best formulation.
article_number: '100331'
author:
- first_name: Niclas
full_name: Märkle, Niclas
id: '74898'
last_name: Märkle
- first_name: Gernot
full_name: Warnke, Gernot
last_name: Warnke
- first_name: Miriam
full_name: Pein-Hackelbusch, Miriam
id: '64952'
last_name: Pein-Hackelbusch
orcid: 0000-0002-7920-0595
citation:
ama: 'Märkle N, Warnke G, Pein-Hackelbusch M. An iterative process and mixture design
approach for dry granulated ternary blends of filler-binders. International
Journal of Pharmaceutics: X. 2025;9. doi:10.1016/j.ijpx.2025.100331'
apa: 'Märkle, N., Warnke, G., & Pein-Hackelbusch, M. (2025). An iterative process
and mixture design approach for dry granulated ternary blends of filler-binders.
International Journal of Pharmaceutics: X, 9, Article 100331. https://doi.org/10.1016/j.ijpx.2025.100331'
bjps: 'Märkle N, Warnke G and Pein-Hackelbusch M (2025) An Iterative Process
and Mixture Design Approach for Dry Granulated Ternary Blends of Filler-Binders.
International Journal of Pharmaceutics: X 9.'
chicago: 'Märkle, Niclas, Gernot Warnke, and Miriam Pein-Hackelbusch. “An Iterative
Process and Mixture Design Approach for Dry Granulated Ternary Blends of Filler-Binders.”
International Journal of Pharmaceutics: X 9 (2025). https://doi.org/10.1016/j.ijpx.2025.100331.'
chicago-de: 'Märkle, Niclas, Gernot Warnke und Miriam Pein-Hackelbusch. 2025. An
iterative process and mixture design approach for dry granulated ternary blends
of filler-binders. International Journal of Pharmaceutics: X 9. doi:10.1016/j.ijpx.2025.100331,
.'
din1505-2-1: 'Märkle, Niclas ; Warnke, Gernot ; Pein-Hackelbusch,
Miriam: An iterative process and mixture design approach for dry granulated
ternary blends of filler-binders. In: International Journal of Pharmaceutics:
X Bd. 9. Amsterdam, Elsevier BV (2025)'
havard: 'N. Märkle, G. Warnke, M. Pein-Hackelbusch, An iterative process and mixture
design approach for dry granulated ternary blends of filler-binders, International
Journal of Pharmaceutics: X. 9 (2025).'
ieee: 'N. Märkle, G. Warnke, and M. Pein-Hackelbusch, “An iterative process and
mixture design approach for dry granulated ternary blends of filler-binders,”
International Journal of Pharmaceutics: X, vol. 9, Art. no. 100331, 2025,
doi: 10.1016/j.ijpx.2025.100331.'
mla: 'Märkle, Niclas, et al. “An Iterative Process and Mixture Design Approach for
Dry Granulated Ternary Blends of Filler-Binders.” International Journal of
Pharmaceutics: X, vol. 9, 100331, 2025, https://doi.org/10.1016/j.ijpx.2025.100331.'
short: 'N. Märkle, G. Warnke, M. Pein-Hackelbusch, International Journal of Pharmaceutics:
X 9 (2025).'
ufg: 'Märkle, Niclas/Warnke, Gernot/Pein-Hackelbusch, Miriam: An iterative
process and mixture design approach for dry granulated ternary blends of filler-binders,
in: International Journal of Pharmaceutics: X 9 (2025).'
van: 'Märkle N, Warnke G, Pein-Hackelbusch M. An iterative process and mixture design
approach for dry granulated ternary blends of filler-binders. International Journal
of Pharmaceutics: X. 2025;9.'
date_created: 2025-04-11T08:39:07Z
date_updated: 2025-05-08T08:20:23Z
department:
- _id: DEP4022
- _id: DEP4028
doi: 10.1016/j.ijpx.2025.100331
external_id:
pmid:
- '40242454 '
intvolume: ' 9'
keyword:
- Design of experiments
- Roller compaction/dry granulation
- RC/DG
- Dicalcium phosphate
- Microcrystalline cellulose
- Silicified microcrystalline cellulose
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S2590156725000167
oa: '1'
place: Amsterdam
pmid: '1'
publication: 'International Journal of Pharmaceutics: X'
publication_identifier:
eissn:
- 2590-1567
issn:
- 1873-3476
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
status: public
title: An iterative process and mixture design approach for dry granulated ternary
blends of filler-binders
type: scientific_journal_article
user_id: '83781'
volume: 9
year: '2025'
...
---
_id: '7986'
abstract:
- lang: eng
text: Bioprocess development and optimization are still cost- and time-intensive
due to the enormous number of experiments involved. In this study, the recently
introduced model-assisted Design of Experiments (mDoE) concept (Möller et al.
in Bioproc Biosyst Eng 42(5):867, https://doi.org/10.1007/s00449-019-02089-7,
2019) was extended and implemented into a software (“mDoE-toolbox”) to significantly
reduce the number of required cultivations. The application of the toolbox is
exemplary shown in two case studies with Saccharomyces cerevisiae. In the first
case study, a fed-batch process was optimized with respect to the pH value and
linearly rising feeding rates of glucose and nitrogen source. Using the mDoE-toolbox,
the biomass concentration was increased by 30% compared to previously performed
experiments. The second case study was the whole-cell biocatalysis of ethyl acetoacetate
(EAA) to (S)-ethyl-3-hydroxybutyrate (E3HB), for which the feeding rates of glucose,
nitrogen source, and EAA were optimized. An increase of 80% compared to a previously
performed experiment with similar initial conditions was achieved for the E3HB
concentration.
author:
- first_name: André
full_name: Moser, André
last_name: Moser
- first_name: Kim B.
full_name: Kuchemüller, Kim B.
last_name: Kuchemüller
- first_name: Sahar
full_name: Deppe, Sahar
last_name: Deppe
- first_name: Tanja
full_name: Hernández Rodriguez, Tanja
id: '52466'
last_name: Hernández Rodriguez
- first_name: Björn
full_name: Frahm, Björn
id: '45666'
last_name: Frahm
- first_name: Ralf
full_name: Pörtner, Ralf
last_name: Pörtner
- first_name: Volker C.
full_name: Hass, Volker C.
last_name: Hass
- first_name: Johannes
full_name: Möller, Johannes
last_name: Möller
citation:
ama: 'Moser A, Kuchemüller KB, Deppe S, et al. Model-assisted DoE software: Optimization
of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess
and Biosystems Engineering. 2021;44(4):683-700. doi:10.1007/s00449-020-02478-3'
apa: 'Moser, A., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Frahm,
B., Pörtner, R., Hass, V. C., & Möller, J. (2021). Model-assisted DoE software:
Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses.
Bioprocess and Biosystems Engineering, 44(4), 683–700. https://doi.org/10.1007/s00449-020-02478-3'
bjps: 'Moser A et al. (2021) Model-Assisted DoE Software: Optimization
of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses. Bioprocess
and Biosystems Engineering 44, 683–700.'
chicago: 'Moser, André, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez,
Björn Frahm, Ralf Pörtner, Volker C. Hass, and Johannes Möller. “Model-Assisted
DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae
Bioprocesses.” Bioprocess and Biosystems Engineering 44, no. 4 (2021):
683–700. https://doi.org/10.1007/s00449-020-02478-3.'
chicago-de: 'Moser, André, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez,
Björn Frahm, Ralf Pörtner, Volker C. Hass und Johannes Möller. 2021. Model-assisted
DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae
bioprocesses. Bioprocess and Biosystems Engineering 44, Nr. 4: 683–700.
doi:10.1007/s00449-020-02478-3,
.'
din1505-2-1: 'Moser, André ; Kuchemüller, Kim B. ; Deppe,
Sahar ; Hernández Rodriguez, Tanja
; Frahm, Björn ; Pörtner,
Ralf ; Hass, Volker C. ;
Möller, Johannes: Model-assisted
DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae
bioprocesses. In: Bioprocess and Biosystems Engineering Bd. 44. Berlin ;
Heidelberg [u.a.], Springer (2021), Nr. 4, S. 683–700'
havard: 'A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm,
R. Pörtner, V.C. Hass, J. Möller, Model-assisted DoE software: Optimization of
growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, Bioprocess and
Biosystems Engineering. 44 (2021) 683–700.'
ieee: 'A. Moser et al., “Model-assisted DoE software: Optimization of growth
and biocatalysis in Saccharomyces cerevisiae bioprocesses,” Bioprocess and
Biosystems Engineering, vol. 44, no. 4, pp. 683–700, 2021, doi: 10.1007/s00449-020-02478-3.'
mla: 'Moser, André, et al. “Model-Assisted DoE Software: Optimization of Growth
and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses.” Bioprocess and
Biosystems Engineering, vol. 44, no. 4, 2021, pp. 683–700, https://doi.org/10.1007/s00449-020-02478-3.'
short: A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R.
Pörtner, V.C. Hass, J. Möller, Bioprocess and Biosystems Engineering 44 (2021)
683–700.
ufg: 'Moser, André u. a.: Model-assisted DoE software: Optimization of growth
and biocatalysis in Saccharomyces cerevisiae bioprocesses, in: Bioprocess and
Biosystems Engineering 44 (2021), H. 4, S. 683–700.'
van: 'Moser A, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Frahm B, Pörtner
R, et al. Model-assisted DoE software: Optimization of growth and biocatalysis
in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering.
2021;44(4):683–700.'
date_created: 2022-05-05T13:10:11Z
date_updated: 2023-08-21T07:55:05Z
department:
- _id: DEP4021
doi: 10.1007/s00449-020-02478-3
intvolume: ' 44'
issue: '4'
keyword:
- Biocatalysis
- Monte Carlo methods
- Fed-batch strategy
- Model-assisted design of experiments
- Quality by design
language:
- iso: eng
page: 683-700
place: Berlin ; Heidelberg [u.a.]
publication: Bioprocess and Biosystems Engineering
publication_identifier:
eissn:
- 1615-7605
isbn:
- 1615-7591
publication_status: published
publisher: Springer
quality_controlled: '1'
status: public
title: 'Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces
cerevisiae bioprocesses'
type: scientific_journal_article
user_id: '83781'
volume: 44
year: '2021'
...
---
_id: '552'
abstract:
- lang: eng
text: 'Since additive manufacturing (AM) is continuously growing, the influence
of processing conditions and setup parameters on microstructural and mechanical
properties of additively manufacturedcomponents needs to be clarified. The paper
discusses an experimental approach for the identification of influencing parameters
in Selective Laser Melting; this consists of an evaluation of the mechanical and
physical properties of final parts, depending on the chosen process parameters.
The Design of Experiments is used to get valid results from a limited number of
experiments. The research work focuses on the application of a Definitive Screening
Design to identify the most important influencing parameters: Several parameters
of the hatch and the contour exposure are varied, as well as the position and
orientation of the samples in the build chamber. A maraging steel and a CoCr alloy
are used, and the mechanical and physical properties of the samples are evaluated.
The interdependencies between the variation of the factors and the observed properties
are analyzed.'
author:
- first_name: F.
full_name: Simoni, F.
last_name: Simoni
- first_name: Andrea
full_name: Huxol, Andrea
id: '43559'
last_name: Huxol
- first_name: Franz-Josef
full_name: Villmer, Franz-Josef
id: '14290'
last_name: Villmer
citation:
ama: 'Simoni F, Huxol A, Villmer F-J. Analysis of Influencing Parameters on Mechanical
and Physical Properties of SLM Parts. In: Villmer F-J, Padoano E, Department of
Production Engineering and Management, eds. Production Engineering and Management.
Lemgo; 2018:43-55.'
apa: Simoni, F., Huxol, A., & Villmer, F.-J. (2018). Analysis of Influencing
Parameters on Mechanical and Physical Properties of SLM Parts. In F.-J. Villmer,
E. Padoano, & Department of Production Engineering and Management (Eds.),
Production Engineering and Management (pp. 43–55). Lemgo.
bjps: Simoni F, Huxol A and Villmer F-J (2018) Analysis of Influencing Parameters
on Mechanical and Physical Properties of SLM Parts. In Villmer F-J, Padoano E
and Department of Production Engineering and Management (eds), Production Engineering
and Management. Lemgo, pp. 43–55.
chicago: Simoni, F., Andrea Huxol, and Franz-Josef Villmer. “Analysis of Influencing
Parameters on Mechanical and Physical Properties of SLM Parts.” In Production
Engineering and Management, edited by Franz-Josef Villmer, Elio Padoano, and
Department of Production Engineering and Management, 43–55. Lemgo, 2018.
chicago-de: 'Simoni, F., Andrea Huxol und Franz-Josef Villmer. 2018. Analysis of
Influencing Parameters on Mechanical and Physical Properties of SLM Parts. In:
Production Engineering and Management, hg. von Franz-Josef Villmer, Elio
Padoano, und Department of Production Engineering and Management, 43–55. Lemgo.'
din1505-2-1: 'Simoni, F. ; Huxol,
Andrea ; Villmer, Franz-Josef:
Analysis of Influencing Parameters on Mechanical and Physical Properties of SLM
Parts. In: Villmer, F.-J. ; Padoano, E. ; Department
of Production Engineering and Management (Hrsg.): Production Engineering
and Management. Lemgo, 2018, S. 43–55'
havard: 'F. Simoni, A. Huxol, F.-J. Villmer, Analysis of Influencing Parameters
on Mechanical and Physical Properties of SLM Parts, in: F.-J. Villmer, E. Padoano,
Department of Production Engineering and Management (Eds.), Production Engineering
and Management, Lemgo, 2018: pp. 43–55.'
ieee: F. Simoni, A. Huxol, and F.-J. Villmer, “Analysis of Influencing Parameters
on Mechanical and Physical Properties of SLM Parts,” in Production Engineering
and Management, Lemgo, 2018, no. 1, pp. 43–55.
mla: Simoni, F., et al. “Analysis of Influencing Parameters on Mechanical and Physical
Properties of SLM Parts.” Production Engineering and Management, edited
by Franz-Josef Villmer et al., no. 1, 2018, pp. 43–55.
short: 'F. Simoni, A. Huxol, F.-J. Villmer, in: F.-J. Villmer, E. Padoano, Department
of Production Engineering and Management (Eds.), Production Engineering and Management,
Lemgo, 2018, pp. 43–55.'
ufg: 'Simoni, F. et. al. (2018): Analysis of Influencing Parameters on Mechanical
and Physical Properties of SLM Parts, in: Franz-Josef Villmer et. al. (Hgg.):
Production Engineering and Management, Lemgo, S. 43–55.'
van: 'Simoni F, Huxol A, Villmer F-J. Analysis of Influencing Parameters on Mechanical
and Physical Properties of SLM Parts. In: Villmer F-J, Padoano E, Department of
Production Engineering and Management, editors. Production Engineering and Management.
Lemgo; 2018. p. 43–55.'
conference:
end_date: 2018-10-05
location: Lemgo
name: Proceedings 8th International Conference
start_date: 2018-10-04
corporate_editor:
- Department of Production Engineering and Management
- Hochschule Ostwestfalen-Lippe
date_created: 2019-02-13T14:11:15Z
date_updated: 2023-03-15T13:50:00Z
department:
- _id: DEP1306
editor:
- first_name: Franz-Josef
full_name: Villmer, Franz-Josef
last_name: Villmer
- first_name: Elio
full_name: Padoano, Elio
last_name: Padoano
issue: '1'
keyword:
- Additive manufacturing
- Process parameters
- Design of Experiments
- Density measurement
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM2018_proceedings_web.pdf
oa: '1'
page: 43-55
place: Lemgo
publication: Production Engineering and Management
publication_identifier:
isbn:
- 978-3-946856-03-0
publication_status: published
status: public
title: Analysis of Influencing Parameters on Mechanical and Physical Properties of
SLM Parts
type: conference
user_id: '45673'
year: 2018
...
---
_id: '472'
abstract:
- lang: eng
text: "In the context of Industrie 4.0 respectively direct digital manufacturing,
seamless process chains are an important factor. The objective is to shorten the
time between quoting for individually designed products and their production and
delivery. Therefore, reliable automated and fast evaluation procedures are needed
to ensure the quality of the individually designed products in terms of product
safety and reliability. This paper aims \r\nto demonstrate how a metamodel, generated
on simulated data, adapts to the type of product and delivers the required quality
and evaluation procedure. The metamodel guarantees the requested characteristics
of the final product without the consultation of human expert knowledge. As proof
of concept, a simple, well-documented task from the field of construction has
been chosen. The estimation from of the metamodel will meet all safety requirements,
is based on the individual input variables and is confirmed without expert interaction.
Fast, reliable prediction models deriving from complex simulation models are indispensable
conditions for direct digital manufacturing. Using metamodels in automation contexts
will be a foundation of manufacturing in future."
author:
- first_name: Eva
full_name: Scheideler, Eva
id: '61522'
last_name: Scheideler
- first_name: Andrea
full_name: Ahlemeyer-Stubbe, Andrea
last_name: Ahlemeyer-Stubbe
citation:
ama: 'Scheideler E, Ahlemeyer-Stubbe A. Expert Knowledge Systems to Ensure Quality
and Reliability in Direct Digital Manufacturing Enviroments. In: Villmer FJ, Padoano
E, Department of Production Engineering and Management, Hochschule Ostwestfalen-Lippe,
eds. Production Engineering and Management : Proceedings 6th International
Conference, September 29 and 30, 2016 Lemgo, Germany . Vol 2016. Publication
series in direct digital manufacturing . Hochschule Ostwestfalen-Lippe; 2016:269-280.'
apa: 'Scheideler, E., & Ahlemeyer-Stubbe, A. (2016). Expert Knowledge Systems
to Ensure Quality and Reliability in Direct Digital Manufacturing Enviroments.
In F.-J. Villmer, E. Padoano, Department of Production Engineering and Management,
& Hochschule Ostwestfalen-Lippe (Eds.), Production engineering and management :
proceedings 6th international conference, September 29 and 30, 2016 Lemgo, Germany
(Vol. 2016, Issue 1, pp. 269–280). Hochschule Ostwestfalen-Lippe.'
bjps: 'Scheideler E and Ahlemeyer-Stubbe A (2016) Expert Knowledge Systems
to Ensure Quality and Reliability in Direct Digital Manufacturing Enviroments.
In Villmer F-J et al. (eds), Production Engineering and Management : Proceedings
6th International Conference, September 29 and 30, 2016 Lemgo, Germany , vol.
2016. Lemgo: Hochschule Ostwestfalen-Lippe, pp. 269–280.'
chicago: 'Scheideler, Eva, and Andrea Ahlemeyer-Stubbe. “Expert Knowledge Systems
to Ensure Quality and Reliability in Direct Digital Manufacturing Enviroments.”
In Production Engineering and Management : Proceedings 6th International Conference,
September 29 and 30, 2016 Lemgo, Germany , edited by Franz-Josef Villmer,
Elio Padoano, Department of Production Engineering and Management, and Hochschule
Ostwestfalen-Lippe, 2016:269–80. Publication Series in Direct Digital Manufacturing
. Lemgo: Hochschule Ostwestfalen-Lippe, 2016.'
chicago-de: 'Scheideler, Eva und Andrea Ahlemeyer-Stubbe. 2016. Expert Knowledge
Systems to Ensure Quality and Reliability in Direct Digital Manufacturing Enviroments.
In: Production engineering and management : proceedings 6th international conference,
September 29 and 30, 2016 Lemgo, Germany , hg. von Franz-Josef Villmer, Elio
Padoano, Department of Production Engineering and Management, und Hochschule Ostwestfalen-Lippe,
2016:269–280. Publication series in direct digital manufacturing . Lemgo: Hochschule
Ostwestfalen-Lippe.'
din1505-2-1: 'Scheideler, Eva ; Ahlemeyer-Stubbe, Andrea: Expert Knowledge
Systems to Ensure Quality and Reliability in Direct Digital Manufacturing Enviroments.
In: Villmer, F.-J. ; Padoano,
E. ; Department of Production Engineering
and Management ; Hochschule Ostwestfalen-Lippe
(Hrsg.): Production engineering and management : proceedings 6th international
conference, September 29 and 30, 2016 Lemgo, Germany , Publication series
in direct digital manufacturing . Bd. 2016. Lemgo : Hochschule Ostwestfalen-Lippe,
2016, S. 269–280'
havard: 'E. Scheideler, A. Ahlemeyer-Stubbe, Expert Knowledge Systems to Ensure
Quality and Reliability in Direct Digital Manufacturing Enviroments, in: F.-J.
Villmer, E. Padoano, Department of Production Engineering and Management, Hochschule
Ostwestfalen-Lippe (Eds.), Production Engineering and Management : Proceedings
6th International Conference, September 29 and 30, 2016 Lemgo, Germany , Hochschule
Ostwestfalen-Lippe, Lemgo, 2016: pp. 269–280.'
ieee: 'E. Scheideler and A. Ahlemeyer-Stubbe, “Expert Knowledge Systems to Ensure
Quality and Reliability in Direct Digital Manufacturing Enviroments,” in Production
engineering and management : proceedings 6th international conference, September
29 and 30, 2016 Lemgo, Germany , Lemgo, 2016, vol. 2016, no. 1, pp. 269–280.'
mla: 'Scheideler, Eva, and Andrea Ahlemeyer-Stubbe. “Expert Knowledge Systems to
Ensure Quality and Reliability in Direct Digital Manufacturing Enviroments.” Production
Engineering and Management : Proceedings 6th International Conference, September
29 and 30, 2016 Lemgo, Germany , edited by Franz-Josef Villmer et al., vol.
2016, no. 1, Hochschule Ostwestfalen-Lippe, 2016, pp. 269–80.'
short: 'E. Scheideler, A. Ahlemeyer-Stubbe, in: F.-J. Villmer, E. Padoano, Department
of Production Engineering and Management, Hochschule Ostwestfalen-Lippe (Eds.),
Production Engineering and Management : Proceedings 6th International Conference,
September 29 and 30, 2016 Lemgo, Germany , Hochschule Ostwestfalen-Lippe, Lemgo,
2016, pp. 269–280.'
ufg: 'Scheideler, Eva/Ahlemeyer-Stubbe, Andrea: Expert Knowledge Systems
to Ensure Quality and Reliability in Direct Digital Manufacturing Enviroments,
in: Villmer, Franz-Josef u. a. (Hgg.): Production engineering and management :
proceedings 6th international conference, September 29 and 30, 2016 Lemgo, Germany
, Bd. 2016, Lemgo 2016 ( Publication series in direct digital manufacturing ),
S. 269–280.'
van: 'Scheideler E, Ahlemeyer-Stubbe A. Expert Knowledge Systems to Ensure Quality
and Reliability in Direct Digital Manufacturing Enviroments. In: Villmer FJ, Padoano
E, Department of Production Engineering and Management, Hochschule Ostwestfalen-Lippe,
editors. Production engineering and management : proceedings 6th international
conference, September 29 and 30, 2016 Lemgo, Germany . Lemgo: Hochschule Ostwestfalen-Lippe;
2016. p. 269–80. ( Publication series in direct digital manufacturing ; vol.
2016).'
conference:
end_date: 2016-09-30
location: Lemgo
name: '6th International Conference on Production Engineering and Management '
start_date: 2016-09-29
corporate_editor:
- Department of Production Engineering and Management
- Hochschule Ostwestfalen-Lippe
date_created: 2019-01-29T13:06:45Z
date_updated: 2024-03-22T13:18:42Z
department:
- _id: DEP1306
editor:
- first_name: Franz-Josef
full_name: Villmer, Franz-Josef
last_name: Villmer
- first_name: Elio
full_name: Padoano, Elio
last_name: Padoano
intvolume: ' 2016'
issue: '1'
keyword:
- Simulation
- Metamodel
- Computer experiment
- Design of experiments
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_2016_Proceeding_2016_09_14_Inhaltsnavigation.pdf
oa: '1'
page: 269-280
place: Lemgo
publication: 'Production engineering and management : proceedings 6th international
conference, September 29 and 30, 2016 Lemgo, Germany '
publication_identifier:
unknown:
- 978-3-946856-00-9
publication_status: published
publisher: Hochschule Ostwestfalen-Lippe
related_material:
link:
- relation: contains
url: https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_2016_Proceeding_2016_09_14_Inhaltsnavigation.pdf
series_title: "\t Publication series in direct digital manufacturing "
status: public
title: Expert Knowledge Systems to Ensure Quality and Reliability in Direct Digital
Manufacturing Enviroments
type: conference
user_id: '83781'
volume: 2016
year: '2016'
...