---
_id: '12023'
author:
- first_name: Ulrich
  full_name: Müller, Ulrich
  id: '12119'
  last_name: Müller
- first_name: Riham
  full_name: Ibrahem, Riham
  id: '72980'
  last_name: Ibrahem
- first_name: Majed
  full_name: Al Krad, Majed
  last_name: Al Krad
- first_name: Knut
  full_name: Schwarzer, Knut
  id: '13329'
  last_name: Schwarzer
- first_name: Patrick
  full_name: Wilhelm, Patrick
  id: '12013'
  last_name: Wilhelm
citation:
  ama: Müller U, Ibrahem R, Al Krad M, Schwarzer K, Wilhelm P. <i>Das Lemgoer Mechanische
    Sattdampfverfahren für pflanzliche Materialien – Retrospektive und neue Erfahrungen</i>.;
    2024.
  apa: Müller, U., Ibrahem, R., Al Krad, M., Schwarzer, K., &#38; Wilhelm, P. (2024).
    <i>Das Lemgoer Mechanische Sattdampfverfahren für pflanzliche Materialien – Retrospektive
    und neue Erfahrungen</i>. 10. GDL Kongress Lebensmitteltechnologie 2024, Lemgo.
  bjps: <b>Müller U <i>et al.</i></b> (2024) <i>Das Lemgoer Mechanische Sattdampfverfahren
    für pflanzliche Materialien – Retrospektive und neue Erfahrungen</i>. .
  chicago: Müller, Ulrich, Riham Ibrahem, Majed Al Krad, Knut Schwarzer, and Patrick
    Wilhelm. <i>Das Lemgoer Mechanische Sattdampfverfahren für pflanzliche Materialien
    – Retrospektive und neue Erfahrungen</i>, 2024.
  chicago-de: Müller, Ulrich, Riham Ibrahem, Majed Al Krad, Knut Schwarzer und Patrick
    Wilhelm. 2024. <i>Das Lemgoer Mechanische Sattdampfverfahren für pflanzliche Materialien
    – Retrospektive und neue Erfahrungen</i>.
  din1505-2-1: '<span style="font-variant:small-caps;">Müller, Ulrich</span> ; <span
    style="font-variant:small-caps;">Ibrahem, Riham</span> ; <span style="font-variant:small-caps;">Al
    Krad, Majed</span> ; <span style="font-variant:small-caps;">Schwarzer, Knut</span>
    ; <span style="font-variant:small-caps;">Wilhelm, Patrick</span>: <i>Das Lemgoer
    Mechanische Sattdampfverfahren für pflanzliche Materialien – Retrospektive und
    neue Erfahrungen</i>, 2024'
  havard: U. Müller, R. Ibrahem, M. Al Krad, K. Schwarzer, P. Wilhelm, Das Lemgoer
    Mechanische Sattdampfverfahren für pflanzliche Materialien – Retrospektive und
    neue Erfahrungen, 2024.
  ieee: U. Müller, R. Ibrahem, M. Al Krad, K. Schwarzer, and P. Wilhelm, <i>Das Lemgoer
    Mechanische Sattdampfverfahren für pflanzliche Materialien – Retrospektive und
    neue Erfahrungen</i>. 2024.
  mla: Müller, Ulrich, et al. <i>Das Lemgoer Mechanische Sattdampfverfahren für pflanzliche
    Materialien – Retrospektive und neue Erfahrungen</i>. 2024.
  short: U. Müller, R. Ibrahem, M. Al Krad, K. Schwarzer, P. Wilhelm, Das Lemgoer
    Mechanische Sattdampfverfahren für pflanzliche Materialien – Retrospektive und
    neue Erfahrungen, 2024.
  ufg: '<b>Müller, Ulrich u. a.</b>: Das Lemgoer Mechanische Sattdampfverfahren für
    pflanzliche Materialien – Retrospektive und neue Erfahrungen, o. O. 2024.'
  van: Müller U, Ibrahem R, Al Krad M, Schwarzer K, Wilhelm P. Das Lemgoer Mechanische
    Sattdampfverfahren für pflanzliche Materialien – Retrospektive und neue Erfahrungen.
    2024.
conference:
  end_date: 2024-10-12
  location: Lemgo
  name: 10. GDL Kongress Lebensmitteltechnologie 2024
  start_date: 2024-10-11
date_created: 2024-11-06T17:07:41Z
date_updated: 2024-11-08T14:18:30Z
department:
- _id: DEP4009
- _id: DEP4028
keyword:
- steam sterilization
- dried plants
- wet plants
- decontamination
- active substances
language:
- iso: ger
publication_status: published
status: public
title: Das Lemgoer Mechanische Sattdampfverfahren für pflanzliche Materialien – Retrospektive
  und neue Erfahrungen
type: conference_speech
user_id: '83781'
year: '2024'
...
---
_id: '12213'
abstract:
- lang: eng
  text: Within freshwater networks, lakes and reservoirs are reactors that modify
    nutrient dynamics. Their functioning is based on an interplay of hydrological
    and biogeochemical processes, rendering them vulnerable to climate change. Future
    changes in catchment characteristics are likely to alter the timing and magnitude
    of nutrient concentrations in discharge. This study investigated the impact of
    changing variability of nutrient concentrations on lake and reservoir dynamics.
    We examined intraannual nutrient retention and analyzed the role of reservoirs
    in reconfiguring the variability of nutrients. Utilizing the 1D lake model GOTM-WET,
    we simulated nutrient processing in a mesotrophic reservoir. Further, we performed
    scenario simulations by modifying the variability of inflow nitrogen and phosphorus
    concentrations. Our findings indicate that the reservoir removed ∼4% and ∼12%
    of total nitrogen (TN) and total phosphorus (TP), respectively. Particulate fractions
    were retained efficiently, but there was a net export of dissolved organic fractions.
    Regarding mixing and stratification periods, however, we observed net nitrogen
    export during stratification in certain years. During stratification, outflow
    concentration variability remained relatively unchanged for TN and TP compared
    to inflow concentrations. Conversely, phosphate and nitrate concentration variability
    increased in the outflow because of in-lake assimilation and the influence of
    hydrological events. With increasing inflow concentration variability during stratification,
    there was decreased removal of TN and TP by the reservoir, but increased variability
    of concentration. By evaluating the lake's capacity to attenuate variability of
    nutrient inflows under altered conditions, there are opportunities to improve
    monitoring of nutrient export and evaluate the potential impact of nutrient peaks
    on downstream drinking water resources and ecosystems.
author:
- first_name: Maria
  full_name: Determann, Maria
  last_name: Determann
- first_name: Andreas
  full_name: Musolff, Andreas
  last_name: Musolff
- first_name: Marieke A.
  full_name: Frassl, Marieke A.
  last_name: Frassl
- first_name: Karsten
  full_name: Rinke, Karsten
  last_name: Rinke
- first_name: Tom
  full_name: Shatwell, Tom
  id: '86424'
  last_name: Shatwell
  orcid: 0000-0002-4520-7916
citation:
  ama: 'Determann M, Musolff A, Frassl MA, Rinke K, Shatwell T. Nutrient retention
    in a small reservoir under changed variability of inflow nutrient concentration.
    <i>Inland waters : journal of the International Society of Limnology</i>. 2024;13(4):560-575.
    doi:<a href="https://doi.org/10.1080/20442041.2024.2305105">10.1080/20442041.2024.2305105</a>'
  apa: 'Determann, M., Musolff, A., Frassl, M. A., Rinke, K., &#38; Shatwell, T. (2024).
    Nutrient retention in a small reservoir under changed variability of inflow nutrient
    concentration. <i>Inland Waters : Journal of the International Society of Limnology</i>,
    <i>13</i>(4), 560–575. <a href="https://doi.org/10.1080/20442041.2024.2305105">https://doi.org/10.1080/20442041.2024.2305105</a>'
  bjps: '<b>Determann M <i>et al.</i></b> (2024) Nutrient Retention in a Small Reservoir
    under Changed Variability of Inflow Nutrient Concentration. <i>Inland waters :
    journal of the International Society of Limnology</i> <b>13</b>, 560–575.'
  chicago: 'Determann, Maria, Andreas Musolff, Marieke A. Frassl, Karsten Rinke, and
    Tom Shatwell. “Nutrient Retention in a Small Reservoir under Changed Variability
    of Inflow Nutrient Concentration.” <i>Inland Waters : Journal of the International
    Society of Limnology</i> 13, no. 4 (2024): 560–75. <a href="https://doi.org/10.1080/20442041.2024.2305105">https://doi.org/10.1080/20442041.2024.2305105</a>.'
  chicago-de: 'Determann, Maria, Andreas Musolff, Marieke A. Frassl, Karsten Rinke
    und Tom Shatwell. 2024. Nutrient retention in a small reservoir under changed
    variability of inflow nutrient concentration. <i>Inland waters : journal of the
    International Society of Limnology</i> 13, Nr. 4: 560–575. doi:<a href="https://doi.org/10.1080/20442041.2024.2305105">10.1080/20442041.2024.2305105</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Determann, Maria</span> ; <span
    style="font-variant:small-caps;">Musolff, Andreas</span> ; <span style="font-variant:small-caps;">Frassl,
    Marieke A.</span> ; <span style="font-variant:small-caps;">Rinke, Karsten</span>
    ; <span style="font-variant:small-caps;">Shatwell, Tom</span>: Nutrient retention
    in a small reservoir under changed variability of inflow nutrient concentration.
    In: <i>Inland waters : journal of the International Society of Limnology</i> Bd.
    13. Ambleside , Freshwater Biological Association (2024), Nr. 4, S. 560–575'
  havard: 'M. Determann, A. Musolff, M.A. Frassl, K. Rinke, T. Shatwell, Nutrient
    retention in a small reservoir under changed variability of inflow nutrient concentration,
    Inland Waters : Journal of the International Society of Limnology. 13 (2024) 560–575.'
  ieee: 'M. Determann, A. Musolff, M. A. Frassl, K. Rinke, and T. Shatwell, “Nutrient
    retention in a small reservoir under changed variability of inflow nutrient concentration,”
    <i>Inland waters : journal of the International Society of Limnology</i>, vol.
    13, no. 4, pp. 560–575, 2024, doi: <a href="https://doi.org/10.1080/20442041.2024.2305105">10.1080/20442041.2024.2305105</a>.'
  mla: 'Determann, Maria, et al. “Nutrient Retention in a Small Reservoir under Changed
    Variability of Inflow Nutrient Concentration.” <i>Inland Waters : Journal of the
    International Society of Limnology</i>, vol. 13, no. 4, 2024, pp. 560–75, <a href="https://doi.org/10.1080/20442041.2024.2305105">https://doi.org/10.1080/20442041.2024.2305105</a>.'
  short: 'M. Determann, A. Musolff, M.A. Frassl, K. Rinke, T. Shatwell, Inland Waters :
    Journal of the International Society of Limnology 13 (2024) 560–575.'
  ufg: '<b>Determann, Maria u. a.</b>: Nutrient retention in a small reservoir under
    changed variability of inflow nutrient concentration, in: <i>Inland waters : journal
    of the International Society of Limnology</i> 13 (2024), H. 4,  S. 560–575.'
  van: 'Determann M, Musolff A, Frassl MA, Rinke K, Shatwell T. Nutrient retention
    in a small reservoir under changed variability of inflow nutrient concentration.
    Inland waters : journal of the International Society of Limnology. 2024;13(4):560–75.'
date_created: 2024-12-08T19:40:16Z
date_updated: 2024-12-11T13:57:10Z
department:
- _id: DEP8022
doi: 10.1080/20442041.2024.2305105
extern: '1'
intvolume: '        13'
issue: '4'
keyword:
- catchment–lake interaction
- concentration variability
- GOTM-WET
- lake nutrient export
- reservoir biogeochemistry
language:
- iso: eng
page: 560-575
place: 'Ambleside '
publication: 'Inland waters : journal of the International Society of Limnology'
publication_identifier:
  eissn:
  - 2044-205X
  issn:
  - 2044-2041
publication_status: published
publisher: Freshwater Biological Association
quality_controlled: '1'
status: public
title: Nutrient retention in a small reservoir under changed variability of inflow
  nutrient concentration
type: scientific_journal_article
user_id: '83781'
volume: 13
year: '2024'
...
---
_id: '10216'
abstract:
- lang: eng
  text: Wet granulation is a frequent process in the pharmaceutical industry. As a
    starting point for numerous dosage forms, the quality of the granulation not only
    affects subsequent production steps but also impacts the quality of the final
    product. It is thus crucial and economical to monitor this operation thoroughly.
    Here, we report on identifying different phases of a granulation process using
    a machine learning approach. The phases reflect the water content which, in turn,
    influences the processability and quality of the granule mass. We used two kinds
    of microphones and an acceleration sensor to capture acoustic emissions and vibrations.
    We trained convolutional neural networks (CNNs) to classify the different phases
    using transformed sound recordings as the input. We achieved a classification
    accuracy of up to 90% using vibrational data and an accuracy of up to 97% using
    the audible microphone data. Our results indicate the suitability of using audible
    sound and machine learning to monitor pharmaceutical processes. Moreover, since
    recording acoustic emissions is contactless, it readily complies with legal regulations
    and presents Good Manufacturing Practices.
article_number: '2153'
author:
- first_name: Ruwen
  full_name: Fulek, Ruwen
  id: '79527'
  last_name: Fulek
- first_name: Selina
  full_name: Ramm, Selina
  id: '68713'
  last_name: Ramm
  orcid: https://orcid.org/0000-0002-0502-8032
- first_name: Christian
  full_name: Kiera, Christian
  last_name: Kiera
- first_name: Miriam
  full_name: Pein-Hackelbusch, Miriam
  id: '64952'
  last_name: Pein-Hackelbusch
  orcid: 0000-0002-7920-0595
- first_name: Ulrich
  full_name: Odefey, Ulrich
  id: '74218'
  last_name: Odefey
citation:
  ama: Fulek R, Ramm S, Kiera C, Pein-Hackelbusch M, Odefey U. A machine learning
    approach to qualitatively evaluate different granulation phases by acoustic emissions.
    <i>Pharmaceutics</i>. 2023;15(8). doi:<a href="https://doi.org/10.3390/pharmaceutics15082153">https://doi.org/10.3390/pharmaceutics15082153</a>
  apa: Fulek, R., Ramm, S., Kiera, C., Pein-Hackelbusch, M., &#38; Odefey, U. (2023).
    A machine learning approach to qualitatively evaluate different granulation phases
    by acoustic emissions. <i>Pharmaceutics</i>, <i>15</i>(8), Article 2153. <a href="https://doi.org/10.3390/pharmaceutics15082153">https://doi.org/10.3390/pharmaceutics15082153</a>
  bjps: <b>Fulek R <i>et al.</i></b> (2023) A Machine Learning Approach to Qualitatively
    Evaluate Different Granulation Phases by Acoustic Emissions. <i>Pharmaceutics</i>
    <b>15</b>.
  chicago: Fulek, Ruwen, Selina Ramm, Christian Kiera, Miriam Pein-Hackelbusch, and
    Ulrich Odefey. “A Machine Learning Approach to Qualitatively Evaluate Different
    Granulation Phases by Acoustic Emissions.” <i>Pharmaceutics</i> 15, no. 8 (2023).
    <a href="https://doi.org/10.3390/pharmaceutics15082153">https://doi.org/10.3390/pharmaceutics15082153</a>.
  chicago-de: Fulek, Ruwen, Selina Ramm, Christian Kiera, Miriam Pein-Hackelbusch
    und Ulrich Odefey. 2023. A machine learning approach to qualitatively evaluate
    different granulation phases by acoustic emissions. <i>Pharmaceutics</i> 15, Nr.
    8. doi:<a href="https://doi.org/10.3390/pharmaceutics15082153">https://doi.org/10.3390/pharmaceutics15082153</a>,
    .
  din1505-2-1: '<span style="font-variant:small-caps;">Fulek, Ruwen</span> ; <span
    style="font-variant:small-caps;">Ramm, Selina</span> ; <span style="font-variant:small-caps;">Kiera,
    Christian</span> ; <span style="font-variant:small-caps;">Pein-Hackelbusch, Miriam</span>
    ; <span style="font-variant:small-caps;">Odefey, Ulrich</span>: A machine learning
    approach to qualitatively evaluate different granulation phases by acoustic emissions.
    In: <i>Pharmaceutics</i> Bd. 15. Basel, MDPI (2023), Nr. 8'
  havard: R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, U. Odefey, A machine learning
    approach to qualitatively evaluate different granulation phases by acoustic emissions,
    Pharmaceutics. 15 (2023).
  ieee: 'R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, and U. Odefey, “A machine
    learning approach to qualitatively evaluate different granulation phases by acoustic
    emissions,” <i>Pharmaceutics</i>, vol. 15, no. 8, Art. no. 2153, 2023, doi: <a
    href="https://doi.org/10.3390/pharmaceutics15082153">https://doi.org/10.3390/pharmaceutics15082153</a>.'
  mla: Fulek, Ruwen, et al. “A Machine Learning Approach to Qualitatively Evaluate
    Different Granulation Phases by Acoustic Emissions.” <i>Pharmaceutics</i>, vol.
    15, no. 8, 2153, 2023, <a href="https://doi.org/10.3390/pharmaceutics15082153">https://doi.org/10.3390/pharmaceutics15082153</a>.
  short: R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, U. Odefey, Pharmaceutics
    15 (2023).
  ufg: '<b>Fulek, Ruwen u. a.</b>: A machine learning approach to qualitatively evaluate
    different granulation phases by acoustic emissions, in: <i>Pharmaceutics</i> 15
    (2023), H. 8.'
  van: Fulek R, Ramm S, Kiera C, Pein-Hackelbusch M, Odefey U. A machine learning
    approach to qualitatively evaluate different granulation phases by acoustic emissions.
    Pharmaceutics. 2023;15(8).
date_created: 2023-08-15T10:48:15Z
date_updated: 2025-07-29T13:21:40Z
department:
- _id: DEP4022
- _id: DEP4028
- _id: DEP4014
doi: https://doi.org/10.3390/pharmaceutics15082153
external_id:
  isi:
  - '001119084200001'
  pmid:
  - '37631367'
intvolume: '        15'
isi: '1'
issue: '8'
keyword:
- wet granulation
- acoustic classification
- machine learning
- convolutional neural networks
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.mdpi.com/1999-4923/15/8/2153
oa: '1'
place: Basel
pmid: '1'
publication: Pharmaceutics
publication_identifier:
  eissn:
  - '1999-4923 '
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: A machine learning approach to qualitatively evaluate different granulation
  phases by acoustic emissions
type: scientific_journal_article
user_id: '83781'
volume: 15
year: '2023'
...
---
_id: '12897'
abstract:
- lang: eng
  text: Glove occlusion might enhance skin sensitivity to a subsequent detergent challenge
    (occlusion effect). Thus, some skin protection creams (PC) claim to protect against
    this effect of occlusion, and are recommended to be used before wearing liquid‐proof
    gloves.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>To
    evaluate the effect of PC applied prior to glove occlusion on the ‘occlusion effect’—refers
    to increased susceptibility of the skin to a model detergent.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>One
    hundred and eleven volunteers were enrolled in a single‐blind, randomized study.
    Seven PCs were applied before glove occlusion over 7 days (D1–D7). After sodium
    lauryl sulphate (SLS) challenge, we compared the irritation between the areas
    treated with PC and occlusion alone. Clinical scoring and bioengineering methods
    (capacitance, transepidermal water loss [TEWL], and colourimetry [erythema]) were
    used to quantify the irritant reactions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>After
    1 week of occlusion and PC application, we did not observe significant changes
    in TEWL, nor in erythema, whereas skin hydration raised in three cream‐treated
    areas. On day 10, after a challenge with SLS, some products significantly aggravated
    the skin irritation as compared to occlusion alone.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The
    ‘occlusion effect’—shown as higher skin susceptibility to a model detergent—was
    not mitigated by PCs when applied prior to glove occlusion. On the contrary, some
    PCs might have negative effects on skin barrier function and augment such sensitivity.
author:
- first_name: Michal
  full_name: Gina, Michal
  last_name: Gina
- first_name: Katharina
  full_name: Wichert, Katharina
  last_name: Wichert
- first_name: Gerd
  full_name: Kutz, Gerd
  id: '12015'
  last_name: Kutz
- first_name: Thomas
  full_name: Brüning, Thomas
  last_name: Brüning
- first_name: Manigé
  full_name: Fartasch, Manigé
  last_name: Fartasch
citation:
  ama: 'Gina M, Wichert K, Kutz G, Brüning T, Fartasch M. Applying skin protective
    cream and the wearing of gloves?—A randomized controlled experimental study. <i>Contact
    dermatitis : environmental and occupational dermatitis</i>. 2023;88(5):372-382.
    doi:<a href="https://doi.org/10.1111/cod.14287">10.1111/cod.14287</a>'
  apa: 'Gina, M., Wichert, K., Kutz, G., Brüning, T., &#38; Fartasch, M. (2023). Applying
    skin protective cream and the wearing of gloves?—A randomized controlled experimental
    study. <i>Contact Dermatitis : Environmental and Occupational Dermatitis</i>,
    <i>88</i>(5), 372–382. <a href="https://doi.org/10.1111/cod.14287">https://doi.org/10.1111/cod.14287</a>'
  bjps: '<b>Gina M <i>et al.</i></b> (2023) Applying Skin Protective Cream and the
    Wearing of Gloves?—A Randomized Controlled Experimental Study. <i>Contact dermatitis :
    environmental and occupational dermatitis</i> <b>88</b>, 372–382.'
  chicago: 'Gina, Michal, Katharina Wichert, Gerd Kutz, Thomas Brüning, and Manigé
    Fartasch. “Applying Skin Protective Cream and the Wearing of Gloves?—A Randomized
    Controlled Experimental Study.” <i>Contact Dermatitis : Environmental and Occupational
    Dermatitis</i> 88, no. 5 (2023): 372–82. <a href="https://doi.org/10.1111/cod.14287">https://doi.org/10.1111/cod.14287</a>.'
  chicago-de: 'Gina, Michal, Katharina Wichert, Gerd Kutz, Thomas Brüning und Manigé
    Fartasch. 2023. Applying skin protective cream and the wearing of gloves?—A randomized
    controlled experimental study. <i>Contact dermatitis : environmental and occupational
    dermatitis</i> 88, Nr. 5: 372–382. doi:<a href="https://doi.org/10.1111/cod.14287">10.1111/cod.14287</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Gina, Michal</span> ; <span
    style="font-variant:small-caps;">Wichert, Katharina</span> ; <span style="font-variant:small-caps;">Kutz,
    Gerd</span> ; <span style="font-variant:small-caps;">Brüning, Thomas</span> ;
    <span style="font-variant:small-caps;">Fartasch, Manigé</span>: Applying skin
    protective cream and the wearing of gloves?—A randomized controlled experimental
    study. In: <i>Contact dermatitis : environmental and occupational dermatitis</i>
    Bd. 88. Oxford, Wiley (2023), Nr. 5, S. 372–382'
  havard: 'M. Gina, K. Wichert, G. Kutz, T. Brüning, M. Fartasch, Applying skin protective
    cream and the wearing of gloves?—A randomized controlled experimental study, Contact
    Dermatitis : Environmental and Occupational Dermatitis. 88 (2023) 372–382.'
  ieee: 'M. Gina, K. Wichert, G. Kutz, T. Brüning, and M. Fartasch, “Applying skin
    protective cream and the wearing of gloves?—A randomized controlled experimental
    study,” <i>Contact dermatitis : environmental and occupational dermatitis</i>,
    vol. 88, no. 5, pp. 372–382, 2023, doi: <a href="https://doi.org/10.1111/cod.14287">10.1111/cod.14287</a>.'
  mla: 'Gina, Michal, et al. “Applying Skin Protective Cream and the Wearing of Gloves?—A
    Randomized Controlled Experimental Study.” <i>Contact Dermatitis : Environmental
    and Occupational Dermatitis</i>, vol. 88, no. 5, 2023, pp. 372–82, <a href="https://doi.org/10.1111/cod.14287">https://doi.org/10.1111/cod.14287</a>.'
  short: 'M. Gina, K. Wichert, G. Kutz, T. Brüning, M. Fartasch, Contact Dermatitis :
    Environmental and Occupational Dermatitis 88 (2023) 372–382.'
  ufg: '<b>Gina, Michal u. a.</b>: Applying skin protective cream and the wearing
    of gloves?—A randomized controlled experimental study, in: <i>Contact dermatitis :
    environmental and occupational dermatitis</i> 88 (2023), H. 5,  S. 372–382.'
  van: 'Gina M, Wichert K, Kutz G, Brüning T, Fartasch M. Applying skin protective
    cream and the wearing of gloves?—A randomized controlled experimental study. Contact
    dermatitis : environmental and occupational dermatitis. 2023;88(5):372–82.'
date_created: 2025-05-08T08:23:15Z
date_updated: 2025-05-08T08:26:34Z
department:
- _id: DEP4022
doi: 10.1111/cod.14287
external_id:
  pmid:
  - '36727715'
intvolume: '        88'
issue: '5'
keyword:
- barrier disturbance
- glove occlusion
- irritant contact dermatitis
- irritation
- non-invasive measuring methods
- occupational contact dermatitis
- skin barrier disturbance
- skin protective cream
- wet work.
language:
- iso: eng
page: 372-382
place: Oxford
pmid: '1'
publication: 'Contact dermatitis : environmental and occupational dermatitis'
publication_identifier:
  eissn:
  - 1600-0536
  issn:
  - 0105-1873
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Applying skin protective cream and the wearing of gloves?—A randomized controlled
  experimental study
type: scientific_journal_article
user_id: '83781'
volume: 88
year: '2023'
...
---
_id: '9568'
abstract:
- lang: eng
  text: Pellet production is a multi-step manufacturing process comprising granulation,
    extrusion and spheronisation. The first step represents a critical control point,
    since the quality of the granule mass highly influences subsequent process steps
    and, consequently, the quality of final pellets. The most important parameter
    of wet granulation is the liquid requirement, which can often only be quantitatively
    evaluated after further process steps. To identify an alternative for optimal
    liquid requirements, experiments were conducted with a formulation based on lactose
    and microcrystalline cellulose. Granules were analyzed with a Powder Vertical
    Shear Rig. We identified the compression density (ρpress) as the said alternative,
    linking information from the powder material and the moisture content (R2 = 0.995).
    We used ρpress to successfully predict liquid requirements for unknown formulation
    compositions. By means of this prediction, pellets with high quality, regarding
    shape and size distribution, were produced by carrying out a multi-step manufacturing
    process. Furthermore, the applicability of ρpress as an alternative quality parameter
    to other placebo formulations and to formulations containing active pharmaceutical
    ingredients (APIs) was demonstrated.
article_number: '2303'
author:
- first_name: Selina
  full_name: Ramm, Selina
  id: '68713'
  last_name: Ramm
  orcid: https://orcid.org/0000-0002-0502-8032
- first_name: Ruwen
  full_name: Fulek, Ruwen
  id: '79527'
  last_name: Fulek
- first_name: Veronika Anna
  full_name: Eberle, Veronika Anna
  last_name: Eberle
- first_name: Christian
  full_name: Kiera, Christian
  last_name: Kiera
- first_name: Ulrich
  full_name: Odefey, Ulrich
  id: '74218'
  last_name: Odefey
- first_name: Miriam
  full_name: Pein-Hackelbusch, Miriam
  id: '64952'
  last_name: Pein-Hackelbusch
  orcid: 0000-0002-7920-0595
citation:
  ama: Ramm S, Fulek R, Eberle VA, Kiera C, Odefey U, Pein-Hackelbusch M. Compression
    Density as an Alternative to Identify an Optimal Moisture Content for High Shear
    Wet Granulation as an Initial Step for Spheronisation. <i>Pharmaceutics</i>. 2022;14(11).
    doi:<a href="https://doi.org/10.3390/pharmaceutics14112303">https://doi.org/10.3390/pharmaceutics14112303</a>
  apa: Ramm, S., Fulek, R., Eberle, V. A., Kiera, C., Odefey, U., &#38; Pein-Hackelbusch,
    M. (2022). Compression Density as an Alternative to Identify an Optimal Moisture
    Content for High Shear Wet Granulation as an Initial Step for Spheronisation.
    <i>Pharmaceutics</i>, <i>14</i>(11), Article 2303. <a href="https://doi.org/10.3390/pharmaceutics14112303">https://doi.org/10.3390/pharmaceutics14112303</a>
  bjps: <b>Ramm S <i>et al.</i></b> (2022) Compression Density as an Alternative to
    Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial
    Step for Spheronisation. <i>Pharmaceutics</i> <b>14</b>.
  chicago: Ramm, Selina, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich
    Odefey, and Miriam Pein-Hackelbusch. “Compression Density as an Alternative to
    Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial
    Step for Spheronisation.” <i>Pharmaceutics</i> 14, no. 11 (2022). <a href="https://doi.org/10.3390/pharmaceutics14112303">https://doi.org/10.3390/pharmaceutics14112303</a>.
  chicago-de: Ramm, Selina, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich
    Odefey und Miriam Pein-Hackelbusch. 2022. Compression Density as an Alternative
    to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial
    Step for Spheronisation. <i>Pharmaceutics</i> 14, Nr. 11. doi:<a href="https://doi.org/10.3390/pharmaceutics14112303">https://doi.org/10.3390/pharmaceutics14112303</a>,
    .
  din1505-2-1: '<span style="font-variant:small-caps;">Ramm, Selina</span> ; <span
    style="font-variant:small-caps;">Fulek, Ruwen</span> ; <span style="font-variant:small-caps;">Eberle,
    Veronika Anna</span> ; <span style="font-variant:small-caps;">Kiera, Christian</span>
    ; <span style="font-variant:small-caps;">Odefey, Ulrich</span> ; <span style="font-variant:small-caps;">Pein-Hackelbusch,
    Miriam</span>: Compression Density as an Alternative to Identify an Optimal Moisture
    Content for High Shear Wet Granulation as an Initial Step for Spheronisation.
    In: <i>Pharmaceutics</i> Bd. 14. Basel, MDPI (2022), Nr. 11'
  havard: S. Ramm, R. Fulek, V.A. Eberle, C. Kiera, U. Odefey, M. Pein-Hackelbusch,
    Compression Density as an Alternative to Identify an Optimal Moisture Content
    for High Shear Wet Granulation as an Initial Step for Spheronisation., Pharmaceutics.
    14 (2022).
  ieee: 'S. Ramm, R. Fulek, V. A. Eberle, C. Kiera, U. Odefey, and M. Pein-Hackelbusch,
    “Compression Density as an Alternative to Identify an Optimal Moisture Content
    for High Shear Wet Granulation as an Initial Step for Spheronisation.,” <i>Pharmaceutics</i>,
    vol. 14, no. 11, Art. no. 2303, 2022, doi: <a href="https://doi.org/10.3390/pharmaceutics14112303">https://doi.org/10.3390/pharmaceutics14112303</a>.'
  mla: Ramm, Selina, et al. “Compression Density as an Alternative to Identify an
    Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for
    Spheronisation.” <i>Pharmaceutics</i>, vol. 14, no. 11, 2303, 2022, <a href="https://doi.org/10.3390/pharmaceutics14112303">https://doi.org/10.3390/pharmaceutics14112303</a>.
  short: S. Ramm, R. Fulek, V.A. Eberle, C. Kiera, U. Odefey, M. Pein-Hackelbusch,
    Pharmaceutics 14 (2022).
  ufg: '<b>Ramm, Selina u. a.</b>: Compression Density as an Alternative to Identify
    an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step
    for Spheronisation., in: <i>Pharmaceutics</i> 14 (2022), H. 11.'
  van: Ramm S, Fulek R, Eberle VA, Kiera C, Odefey U, Pein-Hackelbusch M. Compression
    Density as an Alternative to Identify an Optimal Moisture Content for High Shear
    Wet Granulation as an Initial Step for Spheronisation. Pharmaceutics. 2022;14(11).
date_created: 2023-03-03T11:23:01Z
date_updated: 2025-07-29T13:22:53Z
department:
- _id: DEP4022
- _id: DEP4028
- _id: DEP4014
doi: https://doi.org/10.3390/pharmaceutics14112303
external_id:
  isi:
  - '000883998100001'
  pmid:
  - '36365122'
intvolume: '        14'
isi: '1'
issue: '11'
keyword:
- wet granulation
- liquid requirement
- granulation endpoint
- compression density
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.mdpi.com/1999-4923/14/11/2303
oa: '1'
place: Basel
pmid: '1'
publication: Pharmaceutics
publication_identifier:
  eissn:
  - 1999-4923
publication_status: published
publisher: MDPI
status: public
title: Compression Density as an Alternative to Identify an Optimal Moisture Content
  for High Shear Wet Granulation as an Initial Step for Spheronisation.
type: scientific_journal_article
user_id: '83781'
volume: 14
year: '2022'
...