[{"main_file_link":[{"open_access":"1","url":"https://www.mdpi.com/1999-4923/15/8/2153"}],"title":"A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions","isi":"1","intvolume":"        15","author":[{"first_name":"Ruwen","full_name":"Fulek, Ruwen","id":"79527","last_name":"Fulek"},{"orcid":"https://orcid.org/0000-0002-0502-8032","first_name":"Selina","last_name":"Ramm","id":"68713","full_name":"Ramm, Selina"},{"full_name":"Kiera, Christian","last_name":"Kiera","first_name":"Christian"},{"orcid":"0000-0002-7920-0595","id":"64952","last_name":"Pein-Hackelbusch","full_name":"Pein-Hackelbusch, Miriam","first_name":"Miriam"},{"first_name":"Ulrich","full_name":"Odefey, Ulrich","id":"74218","last_name":"Odefey"}],"publication_identifier":{"eissn":["1999-4923 "]},"place":"Basel","citation":{"chicago":"Fulek, Ruwen, Selina Ramm, Christian Kiera, Miriam Pein-Hackelbusch, and Ulrich Odefey. “A Machine Learning Approach to Qualitatively Evaluate Different Granulation Phases by Acoustic Emissions.” <i>Pharmaceutics</i> 15, no. 8 (2023). <a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Fulek, Ruwen</span> ; <span style=\"font-variant:small-caps;\">Ramm, Selina</span> ; <span style=\"font-variant:small-caps;\">Kiera, Christian</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span> ; <span style=\"font-variant:small-caps;\">Odefey, Ulrich</span>: A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. In: <i>Pharmaceutics</i> Bd. 15. Basel, MDPI (2023), Nr. 8","bjps":"<b>Fulek R <i>et al.</i></b> (2023) A Machine Learning Approach to Qualitatively Evaluate Different Granulation Phases by Acoustic Emissions. <i>Pharmaceutics</i> <b>15</b>.","ama":"Fulek R, Ramm S, Kiera C, Pein-Hackelbusch M, Odefey U. A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. <i>Pharmaceutics</i>. 2023;15(8). doi:<a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>","van":"Fulek R, Ramm S, Kiera C, Pein-Hackelbusch M, Odefey U. A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. Pharmaceutics. 2023;15(8).","ieee":"R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, and U. Odefey, “A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions,” <i>Pharmaceutics</i>, vol. 15, no. 8, Art. no. 2153, 2023, doi: <a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>.","chicago-de":"Fulek, Ruwen, Selina Ramm, Christian Kiera, Miriam Pein-Hackelbusch und Ulrich Odefey. 2023. A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. <i>Pharmaceutics</i> 15, Nr. 8. doi:<a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>, .","ufg":"<b>Fulek, Ruwen u. a.</b>: A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions, in: <i>Pharmaceutics</i> 15 (2023), H. 8.","mla":"Fulek, Ruwen, et al. “A Machine Learning Approach to Qualitatively Evaluate Different Granulation Phases by Acoustic Emissions.” <i>Pharmaceutics</i>, vol. 15, no. 8, 2153, 2023, <a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>.","apa":"Fulek, R., Ramm, S., Kiera, C., Pein-Hackelbusch, M., &#38; Odefey, U. (2023). A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. <i>Pharmaceutics</i>, <i>15</i>(8), Article 2153. <a href=\"https://doi.org/10.3390/pharmaceutics15082153\">https://doi.org/10.3390/pharmaceutics15082153</a>","short":"R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, U. Odefey, Pharmaceutics 15 (2023).","havard":"R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, U. Odefey, A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions, Pharmaceutics. 15 (2023)."},"date_created":"2023-08-15T10:48:15Z","language":[{"iso":"eng"}],"publication_status":"published","pmid":"1","volume":15,"oa":"1","_id":"10216","article_number":"2153","publication":"Pharmaceutics","issue":"8","date_updated":"2025-07-29T13:21:40Z","doi":"https://doi.org/10.3390/pharmaceutics15082153","quality_controlled":"1","external_id":{"pmid":["37631367"],"isi":["001119084200001"]},"type":"scientific_journal_article","publisher":"MDPI","keyword":["wet granulation","acoustic classification","machine learning","convolutional neural networks"],"abstract":[{"lang":"eng","text":"Wet granulation is a frequent process in the pharmaceutical industry. As a starting point for numerous dosage forms, the quality of the granulation not only affects subsequent production steps but also impacts the quality of the final product. It is thus crucial and economical to monitor this operation thoroughly. Here, we report on identifying different phases of a granulation process using a machine learning approach. The phases reflect the water content which, in turn, influences the processability and quality of the granule mass. We used two kinds of microphones and an acceleration sensor to capture acoustic emissions and vibrations. We trained convolutional neural networks (CNNs) to classify the different phases using transformed sound recordings as the input. We achieved a classification accuracy of up to 90% using vibrational data and an accuracy of up to 97% using the audible microphone data. Our results indicate the suitability of using audible sound and machine learning to monitor pharmaceutical processes. Moreover, since recording acoustic emissions is contactless, it readily complies with legal regulations and presents Good Manufacturing Practices."}],"year":"2023","user_id":"83781","department":[{"_id":"DEP4022"},{"_id":"DEP4028"},{"_id":"DEP4014"}],"status":"public"},{"main_file_link":[{"url":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=1529759"}],"date_updated":"2023-03-15T13:49:38Z","doi":" 10.1109/ICIP.2005.1529759","title":"A Simplified Scheme For Hardware-Based Pattern Recognition","citation":{"van":"Henke T, Lohweg V. A Simplified Scheme For Hardware-Based Pattern Recognition. In: IEEE International Conference On Image Processing (ICIP), Proceedings. Genova: IEEE; 2005. p. 349–52.","ama":"Henke T, Lohweg V. A Simplified Scheme For Hardware-Based Pattern Recognition. In: <i>IEEE International Conference On Image Processing (ICIP), Proceedings</i>. Genova: IEEE; 2005:349-352. doi:<a href=\"https://doi.org/ 10.1109/ICIP.2005.1529759\"> 10.1109/ICIP.2005.1529759</a>","ieee":"T. Henke and V. Lohweg, “A Simplified Scheme For Hardware-Based Pattern Recognition,” in <i>IEEE International Conference On Image Processing (ICIP), Proceedings</i>, 2005, pp. 349–352.","chicago":"Henke, Tobias, and Volker Lohweg. “A Simplified Scheme For Hardware-Based Pattern Recognition.” In <i>IEEE International Conference On Image Processing (ICIP), Proceedings</i>, 349–52. Genova: IEEE, 2005. <a href=\"https://doi.org/ 10.1109/ICIP.2005.1529759\">https://doi.org/ 10.1109/ICIP.2005.1529759</a>.","bjps":"<b>Henke T and Lohweg V</b> (2005) A Simplified Scheme For Hardware-Based Pattern Recognition. <i>IEEE International Conference On Image Processing (ICIP), Proceedings</i>. Genova: IEEE, pp. 349–352.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Henke, Tobias</span> ; <span style=\"font-variant:small-caps;\">Lohweg, Volker</span>: A Simplified Scheme For Hardware-Based Pattern Recognition. In: <i>IEEE International Conference On Image Processing (ICIP), Proceedings</i>. Genova : IEEE, 2005, S. 349–352","havard":"T. Henke, V. Lohweg, A Simplified Scheme For Hardware-Based Pattern Recognition, in: IEEE International Conference On Image Processing (ICIP), Proceedings, IEEE, Genova, 2005: pp. 349–352.","ufg":"<b>Henke, Tobias/Lohweg, Volker (2005)</b>: A Simplified Scheme For Hardware-Based Pattern Recognition, in: <i>IEEE International Conference On Image Processing (ICIP), Proceedings</i>, Genova, S. 349–352.","chicago-de":"Henke, Tobias und Volker Lohweg. 2005. A Simplified Scheme For Hardware-Based Pattern Recognition. In: <i>IEEE International Conference On Image Processing (ICIP), Proceedings</i>, 349–352. Genova: IEEE. doi:<a href=\"https://doi.org/ 10.1109/ICIP.2005.1529759,\"> 10.1109/ICIP.2005.1529759,</a> .","short":"T. Henke, V. Lohweg, in: IEEE International Conference On Image Processing (ICIP), Proceedings, IEEE, Genova, 2005, pp. 349–352.","mla":"Henke, Tobias, and Volker Lohweg. “A Simplified Scheme For Hardware-Based Pattern Recognition.” <i>IEEE International Conference On Image Processing (ICIP), Proceedings</i>, IEEE, 2005, pp. 349–52, doi:<a href=\"https://doi.org/ 10.1109/ICIP.2005.1529759\"> 10.1109/ICIP.2005.1529759</a>.","apa":"Henke, T., &#38; Lohweg, V. (2005). A Simplified Scheme For Hardware-Based Pattern Recognition. In <i>IEEE International Conference On Image Processing (ICIP), Proceedings</i> (pp. 349–352). Genova: IEEE. <a href=\"https://doi.org/ 10.1109/ICIP.2005.1529759\">https://doi.org/ 10.1109/ICIP.2005.1529759</a>"},"place":"Genova","publication_status":"published","publisher":"IEEE","date_created":"2019-11-29T13:17:49Z","language":[{"iso":"eng"}],"type":"conference","author":[{"last_name":"Henke","full_name":"Henke, Tobias","first_name":"Tobias"},{"orcid":"0000-0002-3325-7887","first_name":"Volker","full_name":"Lohweg, Volker","id":"1804","last_name":"Lohweg"}],"publication_identifier":{"issn":["1522-4880 "],"eissn":["2381-8549 "],"isbn":["0-7803-9134-9"]},"abstract":[{"text":"Nonlinear spatial transforms and fuzzy pattern classification with unimodal potential functions are established in signal processing. They have proved to be excellent tools in feature extraction and classification. In this paper we present a hardware accelerated image processing and classification scheme for rotation and translation tolerant two-dimensional pattern recognition, which is based on one-dimensional nonlinear discrete circular transforms. However, the scheme is simple; it is stable and therefore well suited for industrial applications. An implementation on one field programmable gate array (FPGA) is proposed.","lang":"eng"}],"page":"349 - 352","_id":"2058","keyword":["Pattern recognition","Field programmable gate arrays","Neural networks","Image processing","Discrete transforms","Signal processing","Image retrieval","Image recognition","Transient analysis","Fuzzy systems"],"status":"public","publication":"IEEE International Conference On Image Processing (ICIP), Proceedings","user_id":"45673","year":2005,"department":[{"_id":"DEP5023"}]}]