---
_id: '12402'
abstract:
- lang: eng
text: In anaerobic technology, pH values are crucial for targeted volatile fatty
acid production. While pH dynamics can be modeled using the Anaerobic Digestion
Model No. 1 (ADM1), simulation results may be biased. To address this issue, the
pH prediction routine of Visual Water, a specialized water chemistry simulator,
was validated. Unlike ADM1, it accounts for ionic strength and activities while
also providing an automated uncertainty analysis. The analysis revealed Visual Water
simulations to better fit measured pH data from acidic solutions in a miniaturized
stirred-tank reactor.
author:
- first_name: Pascal
full_name: Kosse, Pascal
last_name: Kosse
- first_name: Tanja
full_name: Hernández Rodriguez, Tanja
id: '52466'
last_name: Hernández Rodriguez
- first_name: Björn
full_name: Frahm, Björn
id: '45666'
last_name: Frahm
- first_name: Manfred
full_name: Lübken, Manfred
last_name: Lübken
- first_name: Marc
full_name: Wichern, Marc
last_name: Wichern
citation:
ama: Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis
of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.
Chemie Ingenieur Technik. 2024;96(4):528-534. doi:10.1002/cite.202300188
apa: Kosse, P., Hernández Rodriguez, T., Frahm, B., Lübken, M., & Wichern, M.
(2024). Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized
Water Chemistry Simulator. Chemie Ingenieur Technik, 96(4), 528–534.
https://doi.org/10.1002/cite.202300188
bjps: Kosse P et al. (2024) Comparative Analysis of PH Prediction
Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur
Technik 96, 528–534.
chicago: 'Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken,
and Marc Wichern. “Comparative Analysis of PH Prediction Routines in ADM1 and
a Specialized Water Chemistry Simulator.” Chemie Ingenieur Technik 96,
no. 4 (2024): 528–34. https://doi.org/10.1002/cite.202300188.'
chicago-de: 'Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken
und Marc Wichern. 2024. Comparative Analysis of pH Prediction Routines in ADM1
and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik 96,
Nr. 4: 528–534. doi:10.1002/cite.202300188,
.'
din1505-2-1: 'Kosse, Pascal ; Hernández Rodriguez, Tanja ; Frahm,
Björn ; Lübken, Manfred ;
Wichern, Marc: Comparative Analysis
of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.
In: Chemie Ingenieur Technik Bd. 96. Weinheim, Wiley (2024), Nr. 4, S. 528–534'
havard: P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Comparative
Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator,
Chemie Ingenieur Technik. 96 (2024) 528–534.
ieee: 'P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, and M. Wichern, “Comparative
Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator,”
Chemie Ingenieur Technik, vol. 96, no. 4, pp. 528–534, 2024, doi: 10.1002/cite.202300188.'
mla: Kosse, Pascal, et al. “Comparative Analysis of PH Prediction Routines in ADM1
and a Specialized Water Chemistry Simulator.” Chemie Ingenieur Technik,
vol. 96, no. 4, 2024, pp. 528–34, https://doi.org/10.1002/cite.202300188.
short: P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie
Ingenieur Technik 96 (2024) 528–534.
ufg: 'Kosse, Pascal u. a.: Comparative Analysis of pH Prediction Routines
in ADM1 and a Specialized Water Chemistry Simulator, in: Chemie Ingenieur Technik
96 (2024), H. 4, S. 528–534.'
van: Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis
of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.
Chemie Ingenieur Technik. 2024;96(4):528–34.
date_created: 2025-01-29T13:49:16Z
date_updated: 2025-06-25T12:42:09Z
department:
- _id: DEP4000
doi: 10.1002/cite.202300188
external_id:
isi:
- '001169606600001'
intvolume: ' 96'
isi: '1'
issue: '4'
keyword:
- Anaerobic Digestion Model No. 1 (ADM1)
- Anaerobic technology
- pH simulation
- Uncertainty assessment
- Visual Water
language:
- iso: eng
page: 528-534
place: Weinheim
publication: Chemie Ingenieur Technik
publication_identifier:
eissn:
- 1522-2640
issn:
- 0009-286X
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water
Chemistry Simulator
type: scientific_journal_article
user_id: '83781'
volume: 96
year: '2024'
...
---
_id: '11385'
abstract:
- lang: eng
text: Accurate pH calculations are essential for scientists across different disciplines
to design optimal reactor solutions, but they can be arduous to calculate for
complex acid-base solutions. Visual Water is a powerful software tool that provides
accurate pH calculations with automated mathematical uncertainty analysis. Its
workflow is presented and validated using acids and bases, showing a deviation
of < 0.2 pH units between measured and calculated pH values. This highlights the
software's reliability, which can help to simplify the work of non-experts in
water chemistry.
author:
- first_name: Pascal
full_name: Kosse, Pascal
last_name: Kosse
- first_name: Tanja
full_name: Hernández Rodriguez, Tanja
id: '52466'
last_name: Hernández Rodriguez
- first_name: Björn
full_name: Frahm, Björn
id: '45666'
last_name: Frahm
- first_name: Manfred
full_name: Lübken, Manfred
last_name: Lübken
- first_name: Marc
full_name: Wichern, Marc
last_name: Wichern
citation:
ama: Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and
Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations.
Chemie Ingenieur Technik. 2023;95(12):1960-1969. doi:10.1002/cite.202300082
apa: Kosse, P., Hernández Rodriguez, T., Frahm, B., Lübken, M., & Wichern, M.
(2023). Validation and Uncertainty Assessment of a Software‐Integrated Workflow
for pH Calculations. Chemie Ingenieur Technik, 95(12), 1960–1969.
https://doi.org/10.1002/cite.202300082
bjps: Kosse P et al. (2023) Validation and Uncertainty Assessment
of a Software‐Integrated Workflow for PH Calculations. Chemie Ingenieur Technik
95, 1960–1969.
chicago: 'Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken,
and Marc Wichern. “Validation and Uncertainty Assessment of a Software‐Integrated
Workflow for PH Calculations.” Chemie Ingenieur Technik 95, no. 12 (2023):
1960–69. https://doi.org/10.1002/cite.202300082.'
chicago-de: 'Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken
und Marc Wichern. 2023. Validation and Uncertainty Assessment of a Software‐Integrated
Workflow for pH Calculations. Chemie Ingenieur Technik 95, Nr. 12: 1960–1969.
doi:10.1002/cite.202300082,
.'
din1505-2-1: 'Kosse, Pascal ; Hernández Rodriguez, Tanja ; Frahm,
Björn ; Lübken, Manfred ;
Wichern, Marc: Validation and Uncertainty
Assessment of a Software‐Integrated Workflow for pH Calculations. In: Chemie
Ingenieur Technik Bd. 95. Weinheim, Wiley (2023), Nr. 12, S. 1960–1969'
havard: P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Validation
and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations,
Chemie Ingenieur Technik. 95 (2023) 1960–1969.
ieee: 'P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, and M. Wichern, “Validation
and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations,”
Chemie Ingenieur Technik, vol. 95, no. 12, pp. 1960–1969, 2023, doi: 10.1002/cite.202300082.'
mla: Kosse, Pascal, et al. “Validation and Uncertainty Assessment of a Software‐Integrated
Workflow for PH Calculations.” Chemie Ingenieur Technik, vol. 95, no. 12,
2023, pp. 1960–69, https://doi.org/10.1002/cite.202300082.
short: P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie
Ingenieur Technik 95 (2023) 1960–1969.
ufg: 'Kosse, Pascal u. a.: Validation and Uncertainty Assessment of a Software‐Integrated
Workflow for pH Calculations, in: Chemie Ingenieur Technik 95 (2023), H.
12, S. 1960–1969.'
van: Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and
Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations.
Chemie Ingenieur Technik. 2023;95(12):1960–9.
date_created: 2024-04-26T06:52:48Z
date_updated: 2025-06-26T07:50:29Z
department:
- _id: DEP4000
doi: 10.1002/cite.202300082
external_id:
isi:
- '001073579300001'
intvolume: ' 95'
isi: '1'
issue: '12'
keyword:
- Acid-base equilibria
- Carboxylic acids
- Dissociation constants
- pH calculation software
- Uncertainty assessment
language:
- iso: eng
page: 1960-1969
place: Weinheim
publication: Chemie Ingenieur Technik
publication_identifier:
eissn:
- 1522-2640
issn:
- 0009-286X
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for
pH Calculations
type: scientific_journal_article
user_id: '83781'
volume: 95
year: '2023'
...
---
_id: '10010'
abstract:
- lang: eng
text: During product development, the customer or internal stakeholders initiate
changes concerning the components or functions of a cyber-physical system (CPS).
The complexity of such a CPS causes difficulties in evaluating the effects of
a component change. Accordingly, product developers need an assistance system
to quantify the impact of a component change on hardware, software, system functions,
and production processes. Therefore, this paper focuses on concepts to evaluate
the effects of component, functional, and process changes and contributes to its
clarification and further understanding of the importance and requirements for
such an assistance system. The literature review assesses the identified methods
regarding their objectives, application objects, level of automation, and relations
characteristics. However, the literature review pointed out that the change prediction
method from Clarkson et al. (2004) is well-established in the literature and able
to quantify the impact of a change.
author:
- first_name: Viktoria
full_name: Mordaschew, Viktoria
id: '79005'
last_name: Mordaschew
- first_name: Jan-Phillip
full_name: Herrmann, Jan-Phillip
id: '75846'
last_name: Herrmann
- first_name: Sven
full_name: Tackenberg, Sven
id: '71470'
last_name: Tackenberg
citation:
ama: 'Mordaschew V, Herrmann JP, Tackenberg S. METHODS OF CHANGE IMPACT ANALYSIS
FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW OF THE LITERATURE. Cambridge
University Press; 2023:2655-2664. doi:https://doi.org/10.1017/pds.2023.266 '
apa: 'Mordaschew, V., Herrmann, J.-P., & Tackenberg, S. (2023). METHODS OF CHANGE
IMPACT ANALYSIS FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW OF THE LITERATURE.
In Proceedings of the International Conference onEngineering Design (ICED23)
(pp. 2655–2664). Cambridge University Press. https://doi.org/10.1017/pds.2023.266 '
bjps: 'Mordaschew V, Herrmann J-P and Tackenberg S (2023) METHODS OF CHANGE
IMPACT ANALYSIS FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW OF THE LITERATURE.
Cambridge: Cambridge University Press.'
chicago: 'Mordaschew, Viktoria, Jan-Phillip Herrmann, and Sven Tackenberg. METHODS
OF CHANGE IMPACT ANALYSIS FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW OF THE
LITERATURE. Proceedings of the International Conference OnEngineering Design
(ICED23). Cambridge: Cambridge University Press, 2023. https://doi.org/10.1017/pds.2023.266 .'
chicago-de: 'Mordaschew, Viktoria, Jan-Phillip Herrmann und Sven Tackenberg. 2023.
METHODS OF CHANGE IMPACT ANALYSIS FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW
OF THE LITERATURE. Proceedings of the International Conference onEngineering
Design (ICED23). Cambridge: Cambridge University Press. doi:https://doi.org/10.1017/pds.2023.266 , .'
din1505-2-1: 'Mordaschew, Viktoria
; Herrmann, Jan-Phillip ; Tackenberg, Sven: METHODS OF CHANGE
IMPACT ANALYSIS FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW OF THE LITERATURE.
Cambridge : Cambridge University Press, 2023'
havard: 'V. Mordaschew, J.-P. Herrmann, S. Tackenberg, METHODS OF CHANGE IMPACT
ANALYSIS FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW OF THE LITERATURE, Cambridge
University Press, Cambridge, 2023.'
ieee: 'V. Mordaschew, J.-P. Herrmann, and S. Tackenberg, METHODS OF CHANGE IMPACT
ANALYSIS FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW OF THE LITERATURE. Cambridge:
Cambridge University Press, 2023, pp. 2655–2664. doi: https://doi.org/10.1017/pds.2023.266 .'
mla: 'Mordaschew, Viktoria, et al. “METHODS OF CHANGE IMPACT ANALYSIS FOR PRODUCT
DEVELOPMENT: A SYSTEMATIC REVIEW OF THE LITERATURE.” Proceedings of the International
Conference OnEngineering Design (ICED23), Cambridge University Press, 2023,
pp. 2655–64, https://doi.org/10.1017/pds.2023.266
.'
short: 'V. Mordaschew, J.-P. Herrmann, S. Tackenberg, METHODS OF CHANGE IMPACT ANALYSIS
FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW OF THE LITERATURE, Cambridge University
Press, Cambridge, 2023.'
ufg: 'Mordaschew, Viktoria/Herrmann, Jan-Phillip/Tackenberg, Sven: METHODS
OF CHANGE IMPACT ANALYSIS FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW OF THE
LITERATURE, Cambridge 2023.'
van: 'Mordaschew V, Herrmann JP, Tackenberg S. METHODS OF CHANGE IMPACT ANALYSIS
FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW OF THE LITERATURE. Proceedings of
the International Conference onEngineering Design (ICED23). Cambridge: Cambridge
University Press; 2023.'
conference:
end_date: 2023-07-28
location: Bordeaux, Frankreich
name: 24th International Conference on Engineering Design (ICED 2023)
start_date: 2023-07-24
date_created: 2023-06-26T10:58:11Z
date_updated: 2023-06-29T12:49:02Z
doi: 'https://doi.org/10.1017/pds.2023.266 '
keyword:
- Product Lifecycle Management (PLM)
- Change Impact
- Complexity
- Uncertainty
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.cambridge.org/core/journals/proceedings-of-the-design-society/article/methods-of-change-impact-analysis-for-product-development-a-systematic-review-of-the-literature/F33BF904B25755EF60388FB7A6A3BAAF
oa: '1'
page: 2655-2664
place: Cambridge
publication: Proceedings of the International Conference onEngineering Design (ICED23)
publication_identifier:
eissn:
- '2732-527X '
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
status: public
title: 'METHODS OF CHANGE IMPACT ANALYSIS FOR PRODUCT DEVELOPMENT: A SYSTEMATIC REVIEW
OF THE LITERATURE'
type: conference_editor_article
user_id: '15514'
year: '2023'
...
---
_id: '11376'
abstract:
- lang: eng
text: concentration is an important objective. The phenotype of the cells
in a reactor plays an important role. Are clonal cell populations showing high
cell-specific growth rates more favorable than cell lines with higher cell-specific
productivities or vice versa? Five clonal Chinese hamster ovary cell populations
were analyzed based on the data of a 3-month-stability study. We adapted a mechanistic
cell culture model to the experimental data of one such clonally derived cell
population. Uncertainties and prior knowledge concerning model parameters were
considered using Bayesian parameter estimations. This model was used then to define
an inoculum train protocol. Based on this, we subsequently simulated the impacts
of differences in growth rates (±10%) and production rates (±10% and ±50%) on
the overall cultivation time, including making the inoculum train cultures; the
final production phase, the volumetric titer in that bioreactor and the ratio
of both, defined as overall process productivity. We showed thus unequivocally
that growth rates have a higher impact (up to three times) on overall process
productivity and for product output per year, whereas cells with higher productivity
can potentially generate higher product concentrations in the production vessel.
article_number: '964'
author:
- first_name: Tanja
full_name: Hernández Rodriguez, Tanja
id: '52466'
last_name: Hernández Rodriguez
- first_name: Sophie
full_name: Morerod, Sophie
last_name: Morerod
- first_name: Ralf
full_name: Pörtner, Ralf
last_name: Pörtner
- first_name: Florian M.
full_name: Wurm, Florian M.
last_name: Wurm
- first_name: Björn
full_name: Frahm, Björn
id: '45666'
last_name: Frahm
citation:
ama: Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations
of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A
Simulation Study. Processes. 2021;9(6). doi:10.3390/pr9060964
apa: Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm,
B. (2021). Considerations of the Impacts of Cell-Specific Growth and Production
Rate on Clone Selection—A Simulation Study. Processes, 9(6), Article
964. https://doi.org/10.3390/pr9060964
bjps: Hernández Rodriguez T et al. (2021) Considerations of the Impacts
of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study.
Processes 9.
chicago: Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm,
and Björn Frahm. “Considerations of the Impacts of Cell-Specific Growth and Production
Rate on Clone Selection—A Simulation Study.” Processes 9, no. 6 (2021).
https://doi.org/10.3390/pr9060964.
chicago-de: Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M.
Wurm und Björn Frahm. 2021. Considerations of the Impacts of Cell-Specific Growth
and Production Rate on Clone Selection—A Simulation Study. Processes 9,
Nr. 6. doi:10.3390/pr9060964,
.
din1505-2-1: 'Hernández Rodriguez, Tanja
; Morerod, Sophie ; Pörtner,
Ralf ; Wurm, Florian M. ;
Frahm, Björn: Considerations of
the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation
Study. In: Processes Bd. 9. Basel, MDPI AG (2021), Nr. 6'
havard: T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations
of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A
Simulation Study, Processes. 9 (2021).
ieee: 'T. Hernández Rodriguez, S. Morerod, R. Pörtner, F. M. Wurm, and B. Frahm,
“Considerations of the Impacts of Cell-Specific Growth and Production Rate on
Clone Selection—A Simulation Study,” Processes, vol. 9, no. 6, Art. no.
964, 2021, doi: 10.3390/pr9060964.'
mla: Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific
Growth and Production Rate on Clone Selection—A Simulation Study.” Processes,
vol. 9, no. 6, 964, 2021, https://doi.org/10.3390/pr9060964.
short: T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Processes
9 (2021).
ufg: 'Hernández Rodriguez, Tanja u. a.: Considerations of the Impacts of
Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study,
in: Processes 9 (2021), H. 6.'
van: Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations
of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A
Simulation Study. Processes. 2021;9(6).
date_created: 2024-04-25T13:34:26Z
date_updated: 2024-05-21T09:29:02Z
department:
- _id: DEP4000
doi: 10.3390/pr9060964
intvolume: ' 9'
issue: '6'
keyword:
- clonal cell population
- phenotypic diversity
- inoculum train
- uncertainty-based
- cell culture model
- biopharmaceutical manufacturing
language:
- iso: eng
place: Basel
publication: Processes
publication_identifier:
eissn:
- 2227-9717
publication_status: published
publisher: MDPI AG
status: public
title: Considerations of the Impacts of Cell-Specific Growth and Production Rate on
Clone Selection—A Simulation Study
type: scientific_journal_article
user_id: '83781'
volume: 9
year: '2021'
...
---
_id: '7983'
abstract:
- lang: eng
text: For the manufacturing of complex biopharmaceuticals using bioreactors with
cultivated mammalian cells, high product concentration is an important objective.
The phenotype of the cells in a reactor plays an important role. Are clonal cell
populations showing high cell-specific growth rates more favorable than cell lines
with higher cell-specific productivities or vice versa? Five clonal Chinese hamster
ovary cell populations were analyzed based on the data of a 3-month-stability
study. We adapted a mechanistic cell culture model to the experimental data of
one such clonally derived cell population. Uncertainties and prior knowledge concerning
model parameters were considered using Bayesian parameter estimations. This model
was used then to define an inoculum train protocol. Based on this, we subsequently
simulated the impacts of differences in growth rates (±10%) and production rates
(±10% and ±50%) on the overall cultivation time, including making the inoculum
train cultures; the final production phase, the volumetric titer in that bioreactor
and the ratio of both, defined as overall process productivity. We showed thus
unequivocally that growth rates have a higher impact (up to three times) on overall
process productivity and for product output per year, whereas cells with higher
productivity can potentially generate higher product concentrations in the production
vessel.
author:
- first_name: Tanja
full_name: Hernández Rodriguez, Tanja
id: '52466'
last_name: Hernández Rodriguez
- first_name: Sophie
full_name: Morerod, Sophie
last_name: Morerod
- first_name: Ralf
full_name: Pörtner, Ralf
last_name: Pörtner
- first_name: Florian M.
full_name: Wurm, Florian M.
last_name: Wurm
- first_name: Björn
full_name: Frahm, Björn
id: '45666'
last_name: Frahm
citation:
ama: 'Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations
of the impacts of cell-specific growth and production rate on clone selection
– a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical
Manufacturing. Vol special issue. Processes : open access journal . MDPI;
2021:49-74. doi:10.3390/pr9060964'
apa: 'Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm,
B. (2021). Considerations of the impacts of cell-specific growth and production
rate on clone selection – a simulation study. In Bioprocess Systems Engineering
Applications in Pharmaceutical Manufacturing: Vol. special issue (pp. 49–74).
MDPI. https://doi.org/10.3390/pr9060964'
bjps: 'Hernández Rodriguez T et al. (2021) Considerations of the Impacts
of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation
Study. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing,
vol. special issue. Basel: MDPI, pp. 49–74.'
chicago: 'Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm,
and Björn Frahm. “Considerations of the Impacts of Cell-Specific Growth and Production
Rate on Clone Selection – a Simulation Study.” In Bioprocess Systems Engineering
Applications in Pharmaceutical Manufacturing, special issue:49–74. Processes :
Open Access Journal . Basel: MDPI, 2021. https://doi.org/10.3390/pr9060964.'
chicago-de: 'Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M.
Wurm und Björn Frahm. 2021. Considerations of the impacts of cell-specific growth
and production rate on clone selection – a simulation study. In: Bioprocess
Systems Engineering Applications in Pharmaceutical Manufacturing, special
issue:49–74. Processes : open access journal . Basel: MDPI. doi:10.3390/pr9060964,
.'
din1505-2-1: 'Hernández Rodriguez, Tanja
; Morerod, Sophie ; Pörtner,
Ralf ; Wurm, Florian M. ;
Frahm, Björn: Considerations of
the impacts of cell-specific growth and production rate on clone selection – a
simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical
Manufacturing, Processes : open access journal . Bd. special issue.
Basel : MDPI, 2021, S. 49–74'
havard: 'T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations
of the impacts of cell-specific growth and production rate on clone selection
– a simulation study, in: Bioprocess Systems Engineering Applications in Pharmaceutical
Manufacturing, MDPI, Basel, 2021: pp. 49–74.'
ieee: 'T. Hernández Rodriguez, S. Morerod, R. Pörtner, F. M. Wurm, and B. Frahm,
“Considerations of the impacts of cell-specific growth and production rate on
clone selection – a simulation study,” in Bioprocess Systems Engineering Applications
in Pharmaceutical Manufacturing, vol. special issue, Basel: MDPI, 2021, pp.
49–74. doi: 10.3390/pr9060964.'
mla: Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific
Growth and Production Rate on Clone Selection – a Simulation Study.” Bioprocess
Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special
issue, MDPI, 2021, pp. 49–74, https://doi.org/10.3390/pr9060964.
short: 'T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, in:
Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI,
Basel, 2021, pp. 49–74.'
ufg: 'Hernández Rodriguez, Tanja u. a.: Considerations of the impacts of
cell-specific growth and production rate on clone selection – a simulation study,
in: o. Hg.: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing,
Band special issue, Basel 2021 (Processes : open access journal ), S.
49–74.'
van: 'Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations
of the impacts of cell-specific growth and production rate on clone selection
– a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical
Manufacturing. Basel: MDPI; 2021. p. 49–74. (Processes : open access journal ;
vol. special issue).'
date_created: 2022-05-05T12:55:52Z
date_updated: 2023-08-16T09:17:50Z
department:
- _id: DEP4021
doi: 10.3390/pr9060964
keyword:
- clonal cell population
- phenotypic diversity
- inoculum train
- uncertainty-based
- cell culture model
- biopharmaceutical manufacturing
language:
- iso: eng
page: 49-74
place: Basel
publication: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing
publication_identifier:
eisbn:
- 978-3-0365-5209-5
isbn:
- 978-3-0365-5210-1
issn:
- '2227-9717 '
publication_status: published
publisher: MDPI
quality_controlled: '1'
series_title: 'Processes : open access journal '
status: public
title: Considerations of the impacts of cell-specific growth and production rate on
clone selection – a simulation study
type: book_chapter
user_id: '83781'
volume: special issue
year: '2021'
...
---
_id: '3349'
abstract:
- lang: eng
text: "Model-based concepts and simulation techniques in combination with digital
tools emerge as a key to explore the full potential of biopharmaceutical production
processes, which contain several challenging development and process steps. One
of these steps is the time- and cost-intensive cell proliferation process (also
called seed train) to increase cell number from cell thawing up to production
scale. Challenges like complex cell metabolism, batch-to-batch variation, variabilities
in cell behavior, and influences of changes in cultivation conditions necessitate
adequate digital solutions to provide information about the current and near future
process state to derive correct process decisions.\r\nFor this purpose digital
seed train twins have proved to be efficient, which digitally display the time-dependent
behavior of important process variables based on mathematical models, strategies,
and adaption procedures.\r\nThis chapter will outline the needs for digitalization
of seed trains, the construction of a digital seed train twin, the role of parameter
estimation, and different statistical methods within this context, which are applicable
to several problems in the field of bioprocessing. The results of a case study
are presented to illustrate a Bayesian approach for parameter estimation and prediction
of an industrial cell culture seed train for seed train digitalization."
author:
- first_name: Tanja
full_name: Hernández Rodriguez, Tanja
id: '52466'
last_name: Hernández Rodriguez
- first_name: Björn
full_name: Frahm, Björn
id: '45666'
last_name: Frahm
citation:
ama: 'Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods.
In: Herwig C, Pörtner R, Möller J, eds. Digital Twins Tools and Concepts for
Smart Biomanufacturing. Vol 176. Advances in Biochemical Engineering/Biotechnology.
Springer; 2021:97-131. doi:https://doi.org/10.1007/10_2020_137'
apa: Hernández Rodriguez, T., & Frahm, B. (2021). Digital Seed Train Twins and
Statistical Methods. In C. Herwig, R. Pörtner, & J. Möller (Eds.), Digital
Twins Tools and Concepts for Smart Biomanufacturing (Vol. 176, pp. 97–131).
Springer. https://doi.org/10.1007/10_2020_137
bjps: 'Hernández Rodriguez T and Frahm B (2021) Digital Seed Train Twins
and Statistical Methods. In Herwig C, Pörtner R and Möller J (eds), Digital
Twins Tools and Concepts for Smart Biomanufacturing, vol. 176. Berlin, Heidelberg:
Springer, pp. 97–131.'
chicago: 'Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins
and Statistical Methods.” In Digital Twins Tools and Concepts for Smart Biomanufacturing,
edited by Christoph Herwig, Ralf Pörtner, and Johannes Möller, 176:97–131.
Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer,
2021. https://doi.org/10.1007/10_2020_137.'
chicago-de: 'Hernández Rodriguez, Tanja und Björn Frahm. 2021. Digital Seed Train
Twins and Statistical Methods. In: Digital Twins Tools and Concepts for Smart
Biomanufacturing, hg. von Christoph Herwig, Ralf Pörtner, und Johannes Möller,
176:97–131. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg:
Springer. doi:https://doi.org/10.1007/10_2020_137,
.'
din1505-2-1: 'Hernández Rodriguez, Tanja
; Frahm, Björn: Digital Seed Train
Twins and Statistical Methods. In: Herwig,
C. ; Pörtner, R. ; Möller, J. (Hrsg.): Digital Twins Tools
and Concepts for Smart Biomanufacturing, Advances in Biochemical Engineering/Biotechnology.
Bd. 176. Berlin, Heidelberg : Springer, 2021, S. 97–131'
havard: 'T. Hernández Rodriguez, B. Frahm, Digital Seed Train Twins and Statistical
Methods, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and
Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021: pp. 97–131.'
ieee: 'T. Hernández Rodriguez and B. Frahm, “Digital Seed Train Twins and Statistical
Methods,” in Digital Twins Tools and Concepts for Smart Biomanufacturing,
vol. 176, C. Herwig, R. Pörtner, and J. Möller, Eds. Berlin, Heidelberg: Springer,
2021, pp. 97–131. doi: https://doi.org/10.1007/10_2020_137.'
mla: Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins and
Statistical Methods.” Digital Twins Tools and Concepts for Smart Biomanufacturing,
edited by Christoph Herwig et al., vol. 176, Springer, 2021, pp. 97–131, https://doi.org/10.1007/10_2020_137.
short: 'T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.),
Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin,
Heidelberg, 2021, pp. 97–131.'
ufg: 'Hernández Rodriguez, Tanja/Frahm, Björn: Digital Seed Train Twins and
Statistical Methods, in: Herwig, Christoph/Pörtner, Ralf/Möller, Johannes (Hgg.):
Digital Twins Tools and Concepts for Smart Biomanufacturing, Bd. 176, Berlin,
Heidelberg 2021 (Advances in Biochemical Engineering/Biotechnology), S. 97–131.'
van: 'Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods.
In: Herwig C, Pörtner R, Möller J, editors. Digital Twins Tools and Concepts for
Smart Biomanufacturing. Berlin, Heidelberg: Springer; 2021. p. 97–131. (Advances
in Biochemical Engineering/Biotechnology; vol. 176).'
date_created: 2020-08-19T07:14:11Z
date_updated: 2023-08-16T06:48:35Z
department:
- _id: DEP4021
doi: https://doi.org/10.1007/10_2020_137
editor:
- first_name: 'Christoph '
full_name: 'Herwig, Christoph '
last_name: Herwig
- first_name: 'Ralf '
full_name: 'Pörtner, Ralf '
last_name: Pörtner
- first_name: 'Johannes '
full_name: 'Möller, Johannes '
last_name: Möller
intvolume: ' 176'
keyword:
- Bayes
- Digital twin
- Parameter estimation
- Seed train
- Uncertainty
language:
- iso: eng
page: 97–131
place: Berlin, Heidelberg
publication: Digital Twins Tools and Concepts for Smart Biomanufacturing
publication_identifier:
eisbn:
- 978-3-030-71660-8
eissn:
- 1616-8542
isbn:
- 978-3-030-71659-2
issn:
- 0724-6145
publication_status: published
publisher: Springer
quality_controlled: '1'
series_title: Advances in Biochemical Engineering/Biotechnology
status: public
title: Digital Seed Train Twins and Statistical Methods
type: book_chapter
user_id: '83781'
volume: 176
year: '2021'
...