---
_id: '12897'
abstract:
- lang: eng
  text: Glove occlusion might enhance skin sensitivity to a subsequent detergent challenge
    (occlusion effect). Thus, some skin protection creams (PC) claim to protect against
    this effect of occlusion, and are recommended to be used before wearing liquid‐proof
    gloves.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>To
    evaluate the effect of PC applied prior to glove occlusion on the ‘occlusion effect’—refers
    to increased susceptibility of the skin to a model detergent.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>One
    hundred and eleven volunteers were enrolled in a single‐blind, randomized study.
    Seven PCs were applied before glove occlusion over 7 days (D1–D7). After sodium
    lauryl sulphate (SLS) challenge, we compared the irritation between the areas
    treated with PC and occlusion alone. Clinical scoring and bioengineering methods
    (capacitance, transepidermal water loss [TEWL], and colourimetry [erythema]) were
    used to quantify the irritant reactions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>After
    1 week of occlusion and PC application, we did not observe significant changes
    in TEWL, nor in erythema, whereas skin hydration raised in three cream‐treated
    areas. On day 10, after a challenge with SLS, some products significantly aggravated
    the skin irritation as compared to occlusion alone.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The
    ‘occlusion effect’—shown as higher skin susceptibility to a model detergent—was
    not mitigated by PCs when applied prior to glove occlusion. On the contrary, some
    PCs might have negative effects on skin barrier function and augment such sensitivity.
author:
- first_name: Michal
  full_name: Gina, Michal
  last_name: Gina
- first_name: Katharina
  full_name: Wichert, Katharina
  last_name: Wichert
- first_name: Gerd
  full_name: Kutz, Gerd
  id: '12015'
  last_name: Kutz
- first_name: Thomas
  full_name: Brüning, Thomas
  last_name: Brüning
- first_name: Manigé
  full_name: Fartasch, Manigé
  last_name: Fartasch
citation:
  ama: 'Gina M, Wichert K, Kutz G, Brüning T, Fartasch M. Applying skin protective
    cream and the wearing of gloves?—A randomized controlled experimental study. <i>Contact
    dermatitis : environmental and occupational dermatitis</i>. 2023;88(5):372-382.
    doi:<a href="https://doi.org/10.1111/cod.14287">10.1111/cod.14287</a>'
  apa: 'Gina, M., Wichert, K., Kutz, G., Brüning, T., &#38; Fartasch, M. (2023). Applying
    skin protective cream and the wearing of gloves?—A randomized controlled experimental
    study. <i>Contact Dermatitis : Environmental and Occupational Dermatitis</i>,
    <i>88</i>(5), 372–382. <a href="https://doi.org/10.1111/cod.14287">https://doi.org/10.1111/cod.14287</a>'
  bjps: '<b>Gina M <i>et al.</i></b> (2023) Applying Skin Protective Cream and the
    Wearing of Gloves?—A Randomized Controlled Experimental Study. <i>Contact dermatitis :
    environmental and occupational dermatitis</i> <b>88</b>, 372–382.'
  chicago: 'Gina, Michal, Katharina Wichert, Gerd Kutz, Thomas Brüning, and Manigé
    Fartasch. “Applying Skin Protective Cream and the Wearing of Gloves?—A Randomized
    Controlled Experimental Study.” <i>Contact Dermatitis : Environmental and Occupational
    Dermatitis</i> 88, no. 5 (2023): 372–82. <a href="https://doi.org/10.1111/cod.14287">https://doi.org/10.1111/cod.14287</a>.'
  chicago-de: 'Gina, Michal, Katharina Wichert, Gerd Kutz, Thomas Brüning und Manigé
    Fartasch. 2023. Applying skin protective cream and the wearing of gloves?—A randomized
    controlled experimental study. <i>Contact dermatitis : environmental and occupational
    dermatitis</i> 88, Nr. 5: 372–382. doi:<a href="https://doi.org/10.1111/cod.14287">10.1111/cod.14287</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Gina, Michal</span> ; <span
    style="font-variant:small-caps;">Wichert, Katharina</span> ; <span style="font-variant:small-caps;">Kutz,
    Gerd</span> ; <span style="font-variant:small-caps;">Brüning, Thomas</span> ;
    <span style="font-variant:small-caps;">Fartasch, Manigé</span>: Applying skin
    protective cream and the wearing of gloves?—A randomized controlled experimental
    study. In: <i>Contact dermatitis : environmental and occupational dermatitis</i>
    Bd. 88. Oxford, Wiley (2023), Nr. 5, S. 372–382'
  havard: 'M. Gina, K. Wichert, G. Kutz, T. Brüning, M. Fartasch, Applying skin protective
    cream and the wearing of gloves?—A randomized controlled experimental study, Contact
    Dermatitis : Environmental and Occupational Dermatitis. 88 (2023) 372–382.'
  ieee: 'M. Gina, K. Wichert, G. Kutz, T. Brüning, and M. Fartasch, “Applying skin
    protective cream and the wearing of gloves?—A randomized controlled experimental
    study,” <i>Contact dermatitis : environmental and occupational dermatitis</i>,
    vol. 88, no. 5, pp. 372–382, 2023, doi: <a href="https://doi.org/10.1111/cod.14287">10.1111/cod.14287</a>.'
  mla: 'Gina, Michal, et al. “Applying Skin Protective Cream and the Wearing of Gloves?—A
    Randomized Controlled Experimental Study.” <i>Contact Dermatitis : Environmental
    and Occupational Dermatitis</i>, vol. 88, no. 5, 2023, pp. 372–82, <a href="https://doi.org/10.1111/cod.14287">https://doi.org/10.1111/cod.14287</a>.'
  short: 'M. Gina, K. Wichert, G. Kutz, T. Brüning, M. Fartasch, Contact Dermatitis :
    Environmental and Occupational Dermatitis 88 (2023) 372–382.'
  ufg: '<b>Gina, Michal u. a.</b>: Applying skin protective cream and the wearing
    of gloves?—A randomized controlled experimental study, in: <i>Contact dermatitis :
    environmental and occupational dermatitis</i> 88 (2023), H. 5,  S. 372–382.'
  van: 'Gina M, Wichert K, Kutz G, Brüning T, Fartasch M. Applying skin protective
    cream and the wearing of gloves?—A randomized controlled experimental study. Contact
    dermatitis : environmental and occupational dermatitis. 2023;88(5):372–82.'
date_created: 2025-05-08T08:23:15Z
date_updated: 2025-05-08T08:26:34Z
department:
- _id: DEP4022
doi: 10.1111/cod.14287
external_id:
  pmid:
  - '36727715'
intvolume: '        88'
issue: '5'
keyword:
- barrier disturbance
- glove occlusion
- irritant contact dermatitis
- irritation
- non-invasive measuring methods
- occupational contact dermatitis
- skin barrier disturbance
- skin protective cream
- wet work.
language:
- iso: eng
page: 372-382
place: Oxford
pmid: '1'
publication: 'Contact dermatitis : environmental and occupational dermatitis'
publication_identifier:
  eissn:
  - 1600-0536
  issn:
  - 0105-1873
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Applying skin protective cream and the wearing of gloves?—A randomized controlled
  experimental study
type: scientific_journal_article
user_id: '83781'
volume: 88
year: '2023'
...