[{"oa":"1","language":[{"iso":"eng"}],"keyword":["e-tongues","performance","qualification","taste masking","bitterness","dosage forms","drug formulations"],"date_created":"2024-05-29T10:06:47Z","publication":"Pharmaceutics","publication_identifier":{"eissn":["1999-4923 "]},"date_updated":"2025-06-24T09:07:27Z","external_id":{"pmid":["38794320"],"isi":["001231317000001"]},"main_file_link":[{"open_access":"1","url":"https://www.mdpi.com/1999-4923/16/5/658"}],"author":[{"full_name":"Steiner, Denise","last_name":"Steiner","first_name":"Denise"},{"first_name":"Alexander","last_name":"Meyer","id":"58585","full_name":"Meyer, Alexander"},{"full_name":"Immohr, Isabell","last_name":"Immohr","first_name":"Isabell"},{"orcid":"0000-0002-7920-0595","full_name":"Pein-Hackelbusch, Miriam","first_name":"Miriam","last_name":"Pein-Hackelbusch","id":"64952"}],"year":"2024","pmid":"1","status":"public","title":"Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients","volume":16,"citation":{"chicago":"Steiner, Denise, Alexander Meyer, Isabell Immohr, and Miriam Pein-Hackelbusch. “Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients.” <i>Pharmaceutics</i> 16, no. 5 (2024). <a href=\"https://doi.org/10.3390/pharmaceutics16050658\">https://doi.org/10.3390/pharmaceutics16050658</a>.","apa":"Steiner, D., Meyer, A., Immohr, I., &#38; Pein-Hackelbusch, M. (2024). Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. <i>Pharmaceutics</i>, <i>16</i>(5). <a href=\"https://doi.org/10.3390/pharmaceutics16050658\">https://doi.org/10.3390/pharmaceutics16050658</a>","ufg":"<b>Steiner, Denise u. a.</b>: Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients, in: <i>Pharmaceutics</i> 16 (2024), H. 5.","bjps":"<b>Steiner D <i>et al.</i></b> (2024) Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. <i>Pharmaceutics</i> <b>16</b>.","havard":"D. Steiner, A. Meyer, I. Immohr, M. Pein-Hackelbusch, Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients, Pharmaceutics. 16 (2024).","mla":"Steiner, Denise, et al. “Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients.” <i>Pharmaceutics</i>, vol. 16, no. 5, 2024, <a href=\"https://doi.org/10.3390/pharmaceutics16050658\">https://doi.org/10.3390/pharmaceutics16050658</a>.","van":"Steiner D, Meyer A, Immohr I, Pein-Hackelbusch M. Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. Pharmaceutics. 2024;16(5).","chicago-de":"Steiner, Denise, Alexander Meyer, Isabell Immohr und Miriam Pein-Hackelbusch. 2024. Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. <i>Pharmaceutics</i> 16, Nr. 5. doi:<a href=\"https://doi.org/10.3390/pharmaceutics16050658\">10.3390/pharmaceutics16050658</a>, .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Steiner, Denise</span> ; <span style=\"font-variant:small-caps;\">Meyer, Alexander</span> ; <span style=\"font-variant:small-caps;\">Immohr, Isabell</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span>: Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. In: <i>Pharmaceutics</i> Bd. 16. Basel, MDPI (2024), Nr. 5","short":"D. Steiner, A. Meyer, I. Immohr, M. Pein-Hackelbusch, Pharmaceutics 16 (2024).","ieee":"D. Steiner, A. Meyer, I. Immohr, and M. Pein-Hackelbusch, “Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients,” <i>Pharmaceutics</i>, vol. 16, no. 5, 2024, doi: <a href=\"https://doi.org/10.3390/pharmaceutics16050658\">10.3390/pharmaceutics16050658</a>.","ama":"Steiner D, Meyer A, Immohr I, Pein-Hackelbusch M. Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. <i>Pharmaceutics</i>. 2024;16(5). doi:<a href=\"https://doi.org/10.3390/pharmaceutics16050658\">10.3390/pharmaceutics16050658</a>"},"doi":"10.3390/pharmaceutics16050658","_id":"11492","place":"Basel","type":"scientific_journal_article","intvolume":"        16","user_id":"83778","abstract":[{"lang":"eng","text":"In this review, we aim to highlight the advantages, challenges, and limitations of electronic tongues (e-tongues) in pharmaceutical drug development. The authors, therefore, critically evaluated the performance of e-tongues regarding their qualification to assess peroral formulations containing bitter active pharmaceutical ingredients. A literature search using the keywords ‘electronic’, ‘tongue’, ‘bitter’, and ‘drug’ in a Web of Science search was therefore initially conducted. Reviewing the publications of the past decade, and further literature where necessary, allowed the authors to discuss whether and how e-tongues perform as expected and whether they have the potential to become a standard tool in drug development. Specifically highlighted are the expectations an e-tongue should meet. Further, a brief insight into the technologies of the utilized e-tongues is given. Reliable protocols were found that enable (i) the qualified performance of e-tongue instruments from an analytical perspective, (ii) proper taste-masking assessments, and (iii) under certain circumstances, the evaluation of bitterness."}],"issue":"5","department":[{"_id":"DEP4028"}],"quality_controlled":"1","publisher":"MDPI","isi":"1","publication_status":"published","article_type":"review"}]