[{"author":[{"first_name":"Heidrun","last_name":"Gehlen","full_name":"Gehlen, Heidrun"},{"full_name":"Inerle, Katharina","last_name":"Inerle","first_name":"Katharina"},{"first_name":"Alexander","full_name":"Bartel, Alexander","last_name":"Bartel"},{"last_name":"Stöckle","full_name":"Stöckle, Sabita Diana","first_name":"Sabita Diana"},{"full_name":"Ulrich, Sebastian","id":"85847","last_name":"Ulrich","first_name":"Sebastian","orcid":"0000-0002-4511-9537"},{"full_name":"Briese, Beatrice","last_name":"Briese","first_name":"Beatrice"},{"first_name":"Reinhard K.","full_name":"Straubinger, Reinhard K.","last_name":"Straubinger"}],"intvolume":"        13","publication_identifier":{"eissn":["2076-2615"]},"citation":{"chicago":"Gehlen, Heidrun, Katharina Inerle, Alexander Bartel, Sabita Diana Stöckle, Sebastian Ulrich, Beatrice Briese, and Reinhard K. Straubinger. “Seroprevalence of Borrelia Burgdorferi Sensu Lato and Anaplasma Phagocytophilum Infections in German Horses.” <i>Animals</i> 13, no. 12 (2023). <a href=\"https://doi.org/10.3390/ani13121984\">https://doi.org/10.3390/ani13121984</a>.","chicago-de":"Gehlen, Heidrun, Katharina Inerle, Alexander Bartel, Sabita Diana Stöckle, Sebastian Ulrich, Beatrice Briese und Reinhard K. Straubinger. 2023. Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses. <i>Animals</i> 13, Nr. 12. doi:<a href=\"https://doi.org/10.3390/ani13121984\">10.3390/ani13121984</a>, .","ufg":"<b>Gehlen, Heidrun u. a.</b>: Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses, in: <i>Animals</i> 13 (2023), H. 12.","apa":"Gehlen, H., Inerle, K., Bartel, A., Stöckle, S. D., Ulrich, S., Briese, B., &#38; Straubinger, R. K. (2023). Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses. <i>Animals</i>, <i>13</i>(12), Article 1984. <a href=\"https://doi.org/10.3390/ani13121984\">https://doi.org/10.3390/ani13121984</a>","mla":"Gehlen, Heidrun, et al. “Seroprevalence of Borrelia Burgdorferi Sensu Lato and Anaplasma Phagocytophilum Infections in German Horses.” <i>Animals</i>, vol. 13, no. 12, 1984, 2023, <a href=\"https://doi.org/10.3390/ani13121984\">https://doi.org/10.3390/ani13121984</a>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Gehlen, Heidrun</span> ; <span style=\"font-variant:small-caps;\">Inerle, Katharina</span> ; <span style=\"font-variant:small-caps;\">Bartel, Alexander</span> ; <span style=\"font-variant:small-caps;\">Stöckle, Sabita Diana</span> ; <span style=\"font-variant:small-caps;\">Ulrich, Sebastian</span> ; <span style=\"font-variant:small-caps;\">Briese, Beatrice</span> ; <span style=\"font-variant:small-caps;\">Straubinger, Reinhard K.</span>: Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses. In: <i>Animals</i> Bd. 13. Basel, MDPI AG (2023), Nr. 12","short":"H. Gehlen, K. Inerle, A. Bartel, S.D. Stöckle, S. Ulrich, B. Briese, R.K. Straubinger, Animals 13 (2023).","bjps":"<b>Gehlen H <i>et al.</i></b> (2023) Seroprevalence of Borrelia Burgdorferi Sensu Lato and Anaplasma Phagocytophilum Infections in German Horses. <i>Animals</i> <b>13</b>.","ama":"Gehlen H, Inerle K, Bartel A, et al. Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses. <i>Animals</i>. 2023;13(12). doi:<a href=\"https://doi.org/10.3390/ani13121984\">10.3390/ani13121984</a>","van":"Gehlen H, Inerle K, Bartel A, Stöckle SD, Ulrich S, Briese B, et al. Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses. Animals. 2023;13(12).","havard":"H. Gehlen, K. Inerle, A. Bartel, S.D. Stöckle, S. Ulrich, B. Briese, R.K. Straubinger, Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses, Animals. 13 (2023).","ieee":"H. Gehlen <i>et al.</i>, “Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses,” <i>Animals</i>, vol. 13, no. 12, Art. no. 1984, 2023, doi: <a href=\"https://doi.org/10.3390/ani13121984\">10.3390/ani13121984</a>."},"place":"Basel","publication_status":"published","volume":13,"date_created":"2025-06-15T09:35:35Z","language":[{"iso":"eng"}],"title":"Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses","publication":"Animals","_id":"12940","article_number":"1984","type":"scientific_journal_article","publisher":"MDPI AG","issue":"12","doi":"10.3390/ani13121984","date_updated":"2025-06-16T09:16:39Z","quality_controlled":"1","year":"2023","user_id":"83781","department":[{"_id":"DEP4010"}],"status":"public","extern":"1","keyword":["equine Lyme borreliosis","equine granulocytic anaplasmosis","seroprevalence","co-infection"],"abstract":[{"text":"There are limited data on Lyme borreliosis (LB), a tick-borne disease caused by the Borrelia burgdorferi sensu lato complex, in horses. Seropositivity is not necessarily associated with clinical disease. Data on seropositivity against Borrelia burgdorferi and Anaplasma phagocytophilum in German horses are sparse. Therefore, serum samples from horses (n = 123) suspected of having Lyme borreliosis and clinically healthy horses (n = 113) from the same stables were tested for specific antibodies against Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum. The samples were screened for antibodies against Borrelia burgdorferi (ELISA and an IgG line immunoblot assay). Furthermore, the samples were examined for antibodies against B. burgdorferi and Anaplasma phagocytophilum with a validated rapid in-house test (SNAP® 4Dx Plus® ELISA). The clinical signs of suspect horses included lameness (n = 36), poor performance (n = 19), and apathy (n = 12). Twenty-three percent (n = 26) of suspect horses and 17% (n = 18) of clinically healthy horses were seropositive for having a Borrelia burgdorferi sensu lato infection (p = 0.371), showing that the detection of specific antibodies against B. burgdorferi alone is not sufficient for a diagnosis of equine LB. Anaplasma phagocytophilum seropositivity and seropositivity against both pathogens was 20%/6% in suspect horses and 16%/2% in the clinically healthy population, showing only minor differences (p = 0.108). Unspecific testing for antibodies against B. burgdorferi without clinical suspicion of Lyme borreliosis is not recommended since the clinical relevance of seropositivity against Borrelia burgdorferi sensu lato remains to be elucidated.","lang":"eng"}]},{"article_number":"633","_id":"12944","publication":"Veterinary Sciences : open access journal","title":"Detection of Borrelia burgdorferi sensu-lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays","volume":9,"publication_status":"published","date_created":"2025-06-15T09:54:05Z","language":[{"iso":"eng"}],"citation":{"ieee":"S. Doff, J. Wenderlein, A. Wiesinger, S. Hiereth, S. Ulrich, and R. Straubinger, “Detection of Borrelia burgdorferi sensu-lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays,” <i>Veterinary Sciences : open access journal</i>, vol. 9, no. 11, Art. no. 633, 2022, doi: <a href=\"https://doi.org/10.3390/vetsci9110633\">10.3390/vetsci9110633</a>.","ama":"Doff S, Wenderlein J, Wiesinger A, Hiereth S, Ulrich S, Straubinger R. Detection of Borrelia burgdorferi sensu-lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays. <i>Veterinary Sciences : open access journal</i>. 2022;9(11). doi:<a href=\"https://doi.org/10.3390/vetsci9110633\">10.3390/vetsci9110633</a>","van":"Doff S, Wenderlein J, Wiesinger A, Hiereth S, Ulrich S, Straubinger R. Detection of Borrelia burgdorferi sensu-lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays. Veterinary Sciences : open access journal. 2022;9(11).","din1505-2-1":"<span style=\"font-variant:small-caps;\">Doff, Sophie</span> ; <span style=\"font-variant:small-caps;\">Wenderlein, Jasmin</span> ; <span style=\"font-variant:small-caps;\">Wiesinger, Anna</span> ; <span style=\"font-variant:small-caps;\">Hiereth, Stephanie</span> ; <span style=\"font-variant:small-caps;\">Ulrich, Sebastian</span> ; <span style=\"font-variant:small-caps;\">Straubinger, Reinhard</span>: Detection of Borrelia burgdorferi sensu-lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays. In: <i>Veterinary Sciences : open access journal</i> Bd. 9. Basel, MDPI (2022), Nr. 11","bjps":"<b>Doff S <i>et al.</i></b> (2022) Detection of Borrelia Burgdorferi Sensu-Lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays. <i>Veterinary Sciences : open access journal</i> <b>9</b>.","chicago":"Doff, Sophie, Jasmin Wenderlein, Anna Wiesinger, Stephanie Hiereth, Sebastian Ulrich, and Reinhard Straubinger. “Detection of Borrelia Burgdorferi Sensu-Lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays.” <i>Veterinary Sciences : Open Access Journal</i> 9, no. 11 (2022). <a href=\"https://doi.org/10.3390/vetsci9110633\">https://doi.org/10.3390/vetsci9110633</a>.","havard":"S. Doff, J. Wenderlein, A. Wiesinger, S. Hiereth, S. Ulrich, R. Straubinger, Detection of Borrelia burgdorferi sensu-lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays, Veterinary Sciences : Open Access Journal. 9 (2022).","mla":"Doff, Sophie, et al. “Detection of Borrelia Burgdorferi Sensu-Lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays.” <i>Veterinary Sciences : Open Access Journal</i>, vol. 9, no. 11, 633, 2022, <a href=\"https://doi.org/10.3390/vetsci9110633\">https://doi.org/10.3390/vetsci9110633</a>.","apa":"Doff, S., Wenderlein, J., Wiesinger, A., Hiereth, S., Ulrich, S., &#38; Straubinger, R. (2022). Detection of Borrelia burgdorferi sensu-lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays. <i>Veterinary Sciences : Open Access Journal</i>, <i>9</i>(11), Article 633. <a href=\"https://doi.org/10.3390/vetsci9110633\">https://doi.org/10.3390/vetsci9110633</a>","short":"S. Doff, J. Wenderlein, A. Wiesinger, S. Hiereth, S. Ulrich, R. Straubinger, Veterinary Sciences : Open Access Journal 9 (2022).","chicago-de":"Doff, Sophie, Jasmin Wenderlein, Anna Wiesinger, Stephanie Hiereth, Sebastian Ulrich und Reinhard Straubinger. 2022. Detection of Borrelia burgdorferi sensu-lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays. <i>Veterinary Sciences : open access journal</i> 9, Nr. 11. doi:<a href=\"https://doi.org/10.3390/vetsci9110633\">10.3390/vetsci9110633</a>, .","ufg":"<b>Doff, Sophie u. a.</b>: Detection of Borrelia burgdorferi sensu-lato-Specific Antibodies in Sera of Canine and Equine Origin—A Comparative Study with Two Line Immunoassays, in: <i>Veterinary Sciences : open access journal</i> 9 (2022), H. 11."},"place":"Basel","publication_identifier":{"eissn":["2306-7381"]},"author":[{"first_name":"Sophie","full_name":"Doff, Sophie","last_name":"Doff"},{"last_name":"Wenderlein","full_name":"Wenderlein, Jasmin","first_name":"Jasmin"},{"first_name":"Anna","full_name":"Wiesinger, Anna","last_name":"Wiesinger"},{"first_name":"Stephanie","full_name":"Hiereth, Stephanie","last_name":"Hiereth"},{"orcid":"0000-0002-4511-9537","first_name":"Sebastian","full_name":"Ulrich, Sebastian","last_name":"Ulrich","id":"85847"},{"full_name":"Straubinger, Reinhard","last_name":"Straubinger","first_name":"Reinhard"}],"intvolume":"         9","abstract":[{"lang":"eng","text":"Lyme borreliosis is a vector-borne disease in humans and animals caused by bacteria from the Borrelia burgdorferi sensu lato complex (Bbsl). The possible transmission of Bbsl from companion animals to humans via ticks makes this disease important in terms of One Health approaches. Thus, early and accurate diagnosis and treatment are of utmost importance. Today’s standard for the detection of specific antibodies against Bbsl is a two-tiered test system based on an ELISA for screening combined with a line immunoassay (LIA) for confirmation. In this study, 200 canine and 200 equine serum samples with known antibody status were tested with two different LIAs (A and B). Results were compared regarding sensitivity, specificity, the diagnostic outcome for dogs and horses, as well as operability of the test. The results for canine serum samples corresponded to 94.0%, making both LIAs a good choice for LB diagnostic in dogs. For equine serum samples, the agreement of both tests was 65.5%, displaying the challenge equine samples still provide in LB diagnostic. Major concerns were the interpretation of the OspA antigen (AG) signal and the use of unspecific (i.e., p100/p83) or too sensitive signals on the LIA. The operability of both LIAs was equally user-friendly. Regarding the tests’ evaluation, the scanning process provided by LIA A was a major advantage considering the comparability of the tests."}],"keyword":["antibody","Borrelia burgdorferi sensu lato","canine","equine","serum diagnosis","line immunoassay"],"extern":"1","status":"public","department":[{"_id":"DEP4010"}],"user_id":"83781","year":"2022","quality_controlled":"1","date_updated":"2025-06-16T11:49:06Z","doi":"10.3390/vetsci9110633","issue":"11","publisher":"MDPI","type":"scientific_journal_article"},{"main_file_link":[{"url":"https://pferdeheilkunde.de/files/20220606.pdf","open_access":"1"}],"title":"Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung)","place":"Stuttgart","citation":{"bjps":"<b>Gehlen H <i>et al.</i></b> (2022) Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung). <i>Pferdeheilkunde </i> <b>38</b>, 544–553.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Gehlen, Heidrun</span> ; <span style=\"font-variant:small-caps;\">Inerle, Katharina S</span> ; <span style=\"font-variant:small-caps;\">Ulrich, Sebastian</span> ; <span style=\"font-variant:small-caps;\">Briese, Beatrice</span> ; <span style=\"font-variant:small-caps;\">Straubinger, Reinhard K.</span>: Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung). In: <i>Pferdeheilkunde </i> Bd. 38. Stuttgart, Hippiatrika-Verl. GmbH  (2022), Nr. 6, S. 544–553","chicago":"Gehlen, Heidrun, Katharina S Inerle, Sebastian Ulrich, Beatrice Briese, and Reinhard K. Straubinger. “Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung).” <i>Pferdeheilkunde </i> 38, no. 6 (2022): 544–53. <a href=\"https://doi.org/10.21836/PEM20220606\">https://doi.org/10.21836/PEM20220606</a>.","ieee":"H. Gehlen, K. S. Inerle, S. Ulrich, B. Briese, and R. K. Straubinger, “Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung),” <i>Pferdeheilkunde </i>, vol. 38, no. 6, pp. 544–553, 2022, doi: <a href=\"https://doi.org/10.21836/PEM20220606\">10.21836/PEM20220606</a>.","ama":"Gehlen H, Inerle KS, Ulrich S, Briese B, Straubinger RK. Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung). <i>Pferdeheilkunde </i>. 2022;38(6):544-553. doi:<a href=\"https://doi.org/10.21836/PEM20220606\">10.21836/PEM20220606</a>","van":"Gehlen H, Inerle KS, Ulrich S, Briese B, Straubinger RK. Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung). Pferdeheilkunde . 2022;38(6):544–53.","short":"H. Gehlen, K.S. Inerle, S. Ulrich, B. Briese, R.K. Straubinger, Pferdeheilkunde  38 (2022) 544–553.","mla":"Gehlen, Heidrun, et al. “Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung).” <i>Pferdeheilkunde </i>, vol. 38, no. 6, 2022, pp. 544–53, <a href=\"https://doi.org/10.21836/PEM20220606\">https://doi.org/10.21836/PEM20220606</a>.","apa":"Gehlen, H., Inerle, K. S., Ulrich, S., Briese, B., &#38; Straubinger, R. K. (2022). Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung). <i>Pferdeheilkunde </i>, <i>38</i>(6), 544–553. <a href=\"https://doi.org/10.21836/PEM20220606\">https://doi.org/10.21836/PEM20220606</a>","ufg":"<b>Gehlen, Heidrun u. a.</b>: Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung), in: <i>Pferdeheilkunde </i> 38 (2022), H. 6,  S. 544–553.","chicago-de":"Gehlen, Heidrun, Katharina S Inerle, Sebastian Ulrich, Beatrice Briese und Reinhard K. Straubinger. 2022. Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung). <i>Pferdeheilkunde </i> 38, Nr. 6: 544–553. doi:<a href=\"https://doi.org/10.21836/PEM20220606\">10.21836/PEM20220606</a>, .","havard":"H. Gehlen, K.S. Inerle, S. Ulrich, B. Briese, R.K. Straubinger, Lyme-Borreliose und Granulozytäre Anaplasmose bei Pferden Teil 2 – Klinische Relevanz (Tierarztbefragung), Pferdeheilkunde . 38 (2022) 544–553."},"language":[{"iso":"ger"}],"date_created":"2025-06-15T10:05:27Z","volume":38,"publication_status":"published","intvolume":"        38","author":[{"full_name":"Gehlen, Heidrun","last_name":"Gehlen","first_name":"Heidrun"},{"first_name":"Katharina S","full_name":"Inerle, Katharina S","last_name":"Inerle"},{"orcid":"0000-0002-4511-9537","first_name":"Sebastian","full_name":"Ulrich, Sebastian","last_name":"Ulrich","id":"85847"},{"last_name":"Briese","full_name":"Briese, Beatrice","first_name":"Beatrice"},{"last_name":"Straubinger","full_name":"Straubinger, Reinhard K.","first_name":"Reinhard K."}],"publication_identifier":{"issn":["0177-7726"],"eissn":["2943-1794 "]},"oa":"1","_id":"12957","publication":"Pferdeheilkunde ","date_updated":"2025-06-16T14:12:46Z","doi":"10.21836/PEM20220606","issue":"6","publisher":"Hippiatrika-Verl. GmbH ","type":"scientific_journal_article","abstract":[{"lang":"eng","text":"Mit dieser Arbeit sollte die klinische Relevanz von Infektionen mit Borrelia burgdorferi sensu lato (Bbsl) sowie Anaplas-\r\nma phagocytophilum (Ap) bei Pferden in Deutschland untersucht und mögliche Assoziationen zwischen typischen klinischen Veränderungen und spezifischen erhöhten Serumantikörperspiegeln gefunden werden. Hierfür wurden Pferde mit dem Verdacht auf eine klinisch manifeste Lyme-Borreliose (LB) deutschlandweit untersucht. Die Tierärzte wurden zudem gebeten, einen Befund- bzw. Fragebogen auszufüllen. Neben einer Blutprobe von dem LB-erkrankten bzw. -verdächtigen Pferd wurde immer auch eine Blutprobe eines gesunden Kontrollpferdes aus dem gleichen Bestand entnommen. Die Blutproben wurden mittels ELISA (enzyme-linked immunosorbent assay) und Line-Immunoassay auf spezifische Antikörper (Ak) gegen Bbsl und zusätzlich mittels eines validierten SNAP-Tests (SNAP® 4Dx Plus® ELISA) auf spezifische Ak für Bbsl und Anaplasma phagocytophilum (Ap) untersucht. Zudem wurde ein manueller Ausstrich auf Einschlusskörperchen in den Granulozyten, die auf eine Ap-Infektion hindeuten, untersucht. Insgesamt wurden 123 LB-Verdachts- und 113 Kontrollpferde an der Studie aufgenommen. 114 Tierarztfragebögen und Blutproben lagen vollständig vor und gingen in die statistische Auswertung ein. Die häufigsten Vorstellungsgründe der LB-Verdachtstiere waren Lahmheit (n = 36; nges = 79; 45,6 %), Leistungsschwäche (n = 19; 24,1 %) und Apathie (n = 12; 15,2 %). Bei fast der Hälfte der Patienten wurden die klinischen Veränderungen bereits seit über sechs Monaten beobachtet (n = 48; nges = 112; 42,9 %). Zahlreiche Tiere zeigten mehrere, oftmals unspezifische klinische Veränderungen (n = 104; nges = 114; 92,2 %) und/oder litten zusätzlich unter einer chronischen Erkrankung (n = 48; nges = 114; 42,5 %). Obwohl in vielen Fällen schon eine weiterführende Infektionsdiagnostik (n = 64 von nges = 114; 56,1 %) durchgeführt worden war, wurden einige Pferde bislang noch nicht weitergehend labordiagnostisch untersucht (n = 14; nges = 114; 12,3 %). Bei 15 % der Probanden (n = 29; nges = 112) war zudem bislang noch keine eingehende Untersuchung einzelner Organsysteme erfolgt. Auf Basis der eigenen serologischen Befunde wurden 51 % (n = 63) der LB Verdachtspferde negativ (49 % der Verdachtspferde; n = 55), 28 % (n = 34) wurden grenzwertig (35 % der Kontrollpferde; n = 40) und 21 % (n = 26) positiv (16 % der Kontrollpferde; n = 18) auf spezifische Ak gegen Bbsl getestet. Ein positiver Ap-spezifischer Ak-Nachweis lag bei 19,5 % der Verdachtspferde (16,8 % der Kontrollpferde) vor. Ein Hinweis auf eine Coinfektion mit Bbsl und Ap konnte bei sieben Verdachtstieren (5,7 %; 2 Kontrollpferde, 1.8 %) gefunden werden. Die Blutausstriche waren bei allen Verdachts- und Kontrolltieren, bei denen sie auswertbar waren (n = 98), ohne besonderen Befund. Die hohe Zahl klinisch inapparenter Verläufe von Infektionen mit Bbsl konnte durch die hohe Zahl seropositiver Probanden (n = 18; nges = 112; 16 %)\r\nin der gesunden Kontrollgruppe (KG) bestätigt werden. Insgesamt ergab sich ein kaum differierender Serostatus von Verdachts- und Kontrollpferden (p = 0,887). Es konnten mit dem gewonnenen Datenmaterial keine pathognomonisch definierten, klinischen Veränderungen für die LB bei Pferden herausgearbeitet werden. Weder das gehäufte Auftreten unspezifischer Störungen des Allgemeinbefindens (p = 0,043), noch Lahmheiten (p = 0,782) oder Gelenkschwellungen (p = 0,013) konnten statistisch signifikant im Zusammenhang mit positivem Bbsl-Ak-Nachweis beobachtet werden. Die Chance für einen positiven Ap-Ak-Nachweis war bei Fieber (OR = 3,54 (1,28–9,73)) und Inappetenz (OR = 4,54 (1,44–14,29)) erhöht. Bei Coinfektionen (Bbsl + Ap) wurden zudem auffallend häufig neurologische Veränderungen, wie Kopfnervenausfälle (p = 0,030) und Hinweise auf eine Meningoenzephalitis (p = 0,003) diagnostiziert, wobei letztere Korrelation aufgrund der geringen Anzahl\r\nan betroffenen Patienten mit einer Unsicherheit hinsichtlich der Praxisrelevanz behaftet ist."}],"page":"544–553","extern":"1","keyword":["Equine Lyme-Borreliose","Equine Granulozytäre Anaplasmose","Seroprävalenz","Coinfektion"],"status":"public","year":"2022","user_id":"83781","department":[{"_id":"DEP4010"}]}]