---
_id: '12978'
abstract:
- lang: eng
  text: Diet change and fatness are supposed to challenge the immune system of the
    cow. Therefore, immunological and haematological consequences of adaptation to
    and continued feeding of a high-energy diet were studied in eight non-pregnant,
    non-lactating Holstein cows over 16 weeks. Blood haptoglobin concentration remained
    unaltered, suggesting that an acute phase reaction was not induced. Stimulation
    ability of peripheral blood mononuclear cells and stimulated oxidative burst capacity
    of granulocytes increased significantly in the course of the experiment after
    an initial drop. While total leucocyte counts increased, the proportion of granulocytes
    increased and that of lymphocytes decreased at the same time as the ratio of CD4+/CD8+
    lymphocytes did. Capability of rumen microbes to detoxify the immune-modulating
    mycotoxin deoxynivalenol (DON) was not compromised as indicated by the exclusive
    presence of de-DON as the detoxified DON metabolite in blood. In conclusion, both
    diet change and prolonged positive energy balance influenced the bovine immune
    system.
author:
- first_name: Sven
  full_name: Dänicke, Sven
  last_name: Dänicke
- first_name: Ulrich
  full_name: Meyer, Ulrich
  last_name: Meyer
- first_name: Janine
  full_name: Winkler, Janine
  last_name: Winkler
- first_name: Sebastian
  full_name: Ulrich, Sebastian
  id: '85847'
  last_name: Ulrich
  orcid: 0000-0002-4511-9537
- first_name: Jana
  full_name: Frahm, Jana
  last_name: Frahm
- first_name: Susanne
  full_name: Kersten, Susanne
  last_name: Kersten
- first_name: Hana
  full_name: Valenta, Hana
  last_name: Valenta
- first_name: Jürgen
  full_name: Rehage, Jürgen
  last_name: Rehage
- first_name: Susanne
  full_name: Häussler, Susanne
  last_name: Häussler
- first_name: Helga
  full_name: Sauerwein, Helga
  last_name: Sauerwein
- first_name: Lena
  full_name: Locher, Lena
  last_name: Locher
citation:
  ama: Dänicke S, Meyer U, Winkler J, et al. Haematological and immunological adaptations
    of non-pregnant, non-lactating dairy cows to a high-energetic diet containing
    mycotoxins. <i>Archives of Animal Nutrition</i>. 2015;70(1):1-16. doi:<a href="https://doi.org/10.1080/1745039x.2015.1117561">10.1080/1745039x.2015.1117561</a>
  apa: Dänicke, S., Meyer, U., Winkler, J., Ulrich, S., Frahm, J., Kersten, S., Valenta,
    H., Rehage, J., Häussler, S., Sauerwein, H., &#38; Locher, L. (2015). Haematological
    and immunological adaptations of non-pregnant, non-lactating dairy cows to a high-energetic
    diet containing mycotoxins. <i>Archives of Animal Nutrition</i>, <i>70</i>(1),
    1–16. <a href="https://doi.org/10.1080/1745039x.2015.1117561">https://doi.org/10.1080/1745039x.2015.1117561</a>
  bjps: <b>Dänicke S <i>et al.</i></b> (2015) Haematological and Immunological Adaptations
    of Non-Pregnant, Non-Lactating Dairy Cows to a High-Energetic Diet Containing
    Mycotoxins. <i>Archives of Animal Nutrition</i> <b>70</b>, 1–16.
  chicago: 'Dänicke, Sven, Ulrich Meyer, Janine Winkler, Sebastian Ulrich, Jana Frahm,
    Susanne Kersten, Hana Valenta, et al. “Haematological and Immunological Adaptations
    of Non-Pregnant, Non-Lactating Dairy Cows to a High-Energetic Diet Containing
    Mycotoxins.” <i>Archives of Animal Nutrition</i> 70, no. 1 (2015): 1–16. <a href="https://doi.org/10.1080/1745039x.2015.1117561">https://doi.org/10.1080/1745039x.2015.1117561</a>.'
  chicago-de: 'Dänicke, Sven, Ulrich Meyer, Janine Winkler, Sebastian Ulrich, Jana
    Frahm, Susanne Kersten, Hana Valenta, u. a. 2015. Haematological and immunological
    adaptations of non-pregnant, non-lactating dairy cows to a high-energetic diet
    containing mycotoxins. <i>Archives of Animal Nutrition</i> 70, Nr. 1: 1–16. doi:<a
    href="https://doi.org/10.1080/1745039x.2015.1117561">10.1080/1745039x.2015.1117561</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;"><span style="font-variant:small-caps;">Dänicke,
    Sven</span> ; <span style="font-variant:small-caps;">Meyer, Ulrich</span> ; <span
    style="font-variant:small-caps;">Winkler, Janine</span> ; <span style="font-variant:small-caps;">Ulrich,
    Sebastian</span> ; <span style="font-variant:small-caps;">Frahm, Jana</span> ;
    <span style="font-variant:small-caps;">Kersten, Susanne</span> ; <span style="font-variant:small-caps;">Valenta,
    Hana</span> ; <span style="font-variant:small-caps;">Rehage, Jürgen</span> ; u. a.</span>:
    Haematological and immunological adaptations of non-pregnant, non-lactating dairy
    cows to a high-energetic diet containing mycotoxins. In: <i>Archives of Animal
    Nutrition</i> Bd. 70. Abingdon, Taylor &#38; Francis (2015), Nr. 1, S. 1–16'
  havard: S. Dänicke, U. Meyer, J. Winkler, S. Ulrich, J. Frahm, S. Kersten, H. Valenta,
    J. Rehage, S. Häussler, H. Sauerwein, L. Locher, Haematological and immunological
    adaptations of non-pregnant, non-lactating dairy cows to a high-energetic diet
    containing mycotoxins, Archives of Animal Nutrition. 70 (2015) 1–16.
  ieee: 'S. Dänicke <i>et al.</i>, “Haematological and immunological adaptations of
    non-pregnant, non-lactating dairy cows to a high-energetic diet containing mycotoxins,”
    <i>Archives of Animal Nutrition</i>, vol. 70, no. 1, pp. 1–16, 2015, doi: <a href="https://doi.org/10.1080/1745039x.2015.1117561">10.1080/1745039x.2015.1117561</a>.'
  mla: Dänicke, Sven, et al. “Haematological and Immunological Adaptations of Non-Pregnant,
    Non-Lactating Dairy Cows to a High-Energetic Diet Containing Mycotoxins.” <i>Archives
    of Animal Nutrition</i>, vol. 70, no. 1, 2015, pp. 1–16, <a href="https://doi.org/10.1080/1745039x.2015.1117561">https://doi.org/10.1080/1745039x.2015.1117561</a>.
  short: S. Dänicke, U. Meyer, J. Winkler, S. Ulrich, J. Frahm, S. Kersten, H. Valenta,
    J. Rehage, S. Häussler, H. Sauerwein, L. Locher, Archives of Animal Nutrition
    70 (2015) 1–16.
  ufg: '<b>Dänicke, Sven u. a.</b>: Haematological and immunological adaptations of
    non-pregnant, non-lactating dairy cows to a high-energetic diet containing mycotoxins,
    in: <i>Archives of Animal Nutrition</i> 70 (2015), H. 1,  S. 1–16.'
  van: Dänicke S, Meyer U, Winkler J, Ulrich S, Frahm J, Kersten S, et al. Haematological
    and immunological adaptations of non-pregnant, non-lactating dairy cows to a high-energetic
    diet containing mycotoxins. Archives of Animal Nutrition. 2015;70(1):1–16.
date_created: 2025-06-15T10:34:57Z
date_updated: 2025-06-18T12:18:46Z
department:
- _id: DEP4010
doi: 10.1080/1745039x.2015.1117561
extern: '1'
intvolume: '        70'
issue: '1'
keyword:
- Dairy cowsdeoxynivalenol
- energy consumption
- functional responses
- haematology
- leucocytes
- mycotoxins
- zearalenone
language:
- iso: eng
page: 1-16
place: Abingdon
publication: Archives of Animal Nutrition
publication_identifier:
  eissn:
  - 1477-2817
  issn:
  - 1745-039X
  unknown:
  - '0003-942X '
publication_status: published
publisher: Taylor & Francis
quality_controlled: '1'
status: public
title: Haematological and immunological adaptations of non-pregnant, non-lactating
  dairy cows to a high-energetic diet containing mycotoxins
type: scientific_journal_article
user_id: '83781'
volume: 70
year: '2015'
...