@misc{12897,
  abstract     = {{Glove occlusion might enhance skin sensitivity to a subsequent detergent challenge (occlusion effect). Thus, some skin protection creams (PC) claim to protect against this effect of occlusion, and are recommended to be used before wearing liquid‐proof gloves.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>To evaluate the effect of PC applied prior to glove occlusion on the ‘occlusion effect’—refers to increased susceptibility of the skin to a model detergent.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>One hundred and eleven volunteers were enrolled in a single‐blind, randomized study. Seven PCs were applied before glove occlusion over 7 days (D1–D7). After sodium lauryl sulphate (SLS) challenge, we compared the irritation between the areas treated with PC and occlusion alone. Clinical scoring and bioengineering methods (capacitance, transepidermal water loss [TEWL], and colourimetry [erythema]) were used to quantify the irritant reactions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>After 1 week of occlusion and PC application, we did not observe significant changes in TEWL, nor in erythema, whereas skin hydration raised in three cream‐treated areas. On day 10, after a challenge with SLS, some products significantly aggravated the skin irritation as compared to occlusion alone.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The ‘occlusion effect’—shown as higher skin susceptibility to a model detergent—was not mitigated by PCs when applied prior to glove occlusion. On the contrary, some PCs might have negative effects on skin barrier function and augment such sensitivity.}},
  author       = {{Gina, Michal and Wichert, Katharina and Kutz, Gerd and Brüning, Thomas and Fartasch, Manigé}},
  booktitle    = {{Contact dermatitis : environmental and occupational dermatitis}},
  issn         = {{1600-0536}},
  keywords     = {{barrier disturbance, glove occlusion, irritant contact dermatitis, irritation, non-invasive measuring methods, occupational contact dermatitis, skin barrier disturbance, skin protective cream, wet work.}},
  number       = {{5}},
  pages        = {{372--382}},
  publisher    = {{Wiley}},
  title        = {{{Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study}}},
  doi          = {{10.1111/cod.14287}},
  volume       = {{88}},
  year         = {{2023}},
}