[{"external_id":{"pmid":["36727715"]},"date_created":"2025-05-08T08:23:15Z","language":[{"iso":"eng"}],"year":"2023","date_updated":"2025-05-08T08:26:34Z","user_id":"83781","volume":88,"_id":"12897","page":"372-382","type":"scientific_journal_article","abstract":[{"text":"Glove occlusion might enhance skin sensitivity to a subsequent detergent challenge (occlusion effect). Thus, some skin protection creams (PC) claim to protect against this effect of occlusion, and are recommended to be used before wearing liquid‐proof gloves.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>To evaluate the effect of PC applied prior to glove occlusion on the ‘occlusion effect’—refers to increased susceptibility of the skin to a model detergent.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>One hundred and eleven volunteers were enrolled in a single‐blind, randomized study. Seven PCs were applied before glove occlusion over 7 days (D1–D7). After sodium lauryl sulphate (SLS) challenge, we compared the irritation between the areas treated with PC and occlusion alone. Clinical scoring and bioengineering methods (capacitance, transepidermal water loss [TEWL], and colourimetry [erythema]) were used to quantify the irritant reactions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>After 1 week of occlusion and PC application, we did not observe significant changes in TEWL, nor in erythema, whereas skin hydration raised in three cream‐treated areas. On day 10, after a challenge with SLS, some products significantly aggravated the skin irritation as compared to occlusion alone.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The ‘occlusion effect’—shown as higher skin susceptibility to a model detergent—was not mitigated by PCs when applied prior to glove occlusion. On the contrary, some PCs might have negative effects on skin barrier function and augment such sensitivity.","lang":"eng"}],"pmid":"1","place":"Oxford","status":"public","author":[{"first_name":"Michal","full_name":"Gina, Michal","last_name":"Gina"},{"last_name":"Wichert","full_name":"Wichert, Katharina","first_name":"Katharina"},{"last_name":"Kutz","full_name":"Kutz, Gerd","id":"12015","first_name":"Gerd"},{"full_name":"Brüning, Thomas","last_name":"Brüning","first_name":"Thomas"},{"first_name":"Manigé","last_name":"Fartasch","full_name":"Fartasch, Manigé"}],"publication":"Contact dermatitis : environmental and occupational dermatitis","department":[{"_id":"DEP4022"}],"title":"Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study","publication_status":"published","publication_identifier":{"issn":["0105-1873"],"eissn":["1600-0536"]},"issue":"5","doi":"10.1111/cod.14287","keyword":["barrier disturbance","glove occlusion","irritant contact dermatitis","irritation","non-invasive measuring methods","occupational contact dermatitis","skin barrier disturbance","skin protective cream","wet work."],"citation":{"havard":"M. Gina, K. Wichert, G. Kutz, T. Brüning, M. Fartasch, Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study, Contact Dermatitis : Environmental and Occupational Dermatitis. 88 (2023) 372–382.","ufg":"<b>Gina, Michal u. a.</b>: Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study, in: <i>Contact dermatitis : environmental and occupational dermatitis</i> 88 (2023), H. 5,  S. 372–382.","ama":"Gina M, Wichert K, Kutz G, Brüning T, Fartasch M. Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study. <i>Contact dermatitis : environmental and occupational dermatitis</i>. 2023;88(5):372-382. doi:<a href=\"https://doi.org/10.1111/cod.14287\">10.1111/cod.14287</a>","apa":"Gina, M., Wichert, K., Kutz, G., Brüning, T., &#38; Fartasch, M. (2023). Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study. <i>Contact Dermatitis : Environmental and Occupational Dermatitis</i>, <i>88</i>(5), 372–382. <a href=\"https://doi.org/10.1111/cod.14287\">https://doi.org/10.1111/cod.14287</a>","van":"Gina M, Wichert K, Kutz G, Brüning T, Fartasch M. Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study. Contact dermatitis : environmental and occupational dermatitis. 2023;88(5):372–82.","ieee":"M. Gina, K. Wichert, G. Kutz, T. Brüning, and M. Fartasch, “Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study,” <i>Contact dermatitis : environmental and occupational dermatitis</i>, vol. 88, no. 5, pp. 372–382, 2023, doi: <a href=\"https://doi.org/10.1111/cod.14287\">10.1111/cod.14287</a>.","chicago":"Gina, Michal, Katharina Wichert, Gerd Kutz, Thomas Brüning, and Manigé Fartasch. “Applying Skin Protective Cream and the Wearing of Gloves?—A Randomized Controlled Experimental Study.” <i>Contact Dermatitis : Environmental and Occupational Dermatitis</i> 88, no. 5 (2023): 372–82. <a href=\"https://doi.org/10.1111/cod.14287\">https://doi.org/10.1111/cod.14287</a>.","short":"M. Gina, K. Wichert, G. Kutz, T. Brüning, M. Fartasch, Contact Dermatitis : Environmental and Occupational Dermatitis 88 (2023) 372–382.","mla":"Gina, Michal, et al. “Applying Skin Protective Cream and the Wearing of Gloves?—A Randomized Controlled Experimental Study.” <i>Contact Dermatitis : Environmental and Occupational Dermatitis</i>, vol. 88, no. 5, 2023, pp. 372–82, <a href=\"https://doi.org/10.1111/cod.14287\">https://doi.org/10.1111/cod.14287</a>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Gina, Michal</span> ; <span style=\"font-variant:small-caps;\">Wichert, Katharina</span> ; <span style=\"font-variant:small-caps;\">Kutz, Gerd</span> ; <span style=\"font-variant:small-caps;\">Brüning, Thomas</span> ; <span style=\"font-variant:small-caps;\">Fartasch, Manigé</span>: Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study. In: <i>Contact dermatitis : environmental and occupational dermatitis</i> Bd. 88. Oxford, Wiley (2023), Nr. 5, S. 372–382","bjps":"<b>Gina M <i>et al.</i></b> (2023) Applying Skin Protective Cream and the Wearing of Gloves?—A Randomized Controlled Experimental Study. <i>Contact dermatitis : environmental and occupational dermatitis</i> <b>88</b>, 372–382.","chicago-de":"Gina, Michal, Katharina Wichert, Gerd Kutz, Thomas Brüning und Manigé Fartasch. 2023. Applying skin protective cream and the wearing of gloves?—A randomized controlled experimental study. <i>Contact dermatitis : environmental and occupational dermatitis</i> 88, Nr. 5: 372–382. doi:<a href=\"https://doi.org/10.1111/cod.14287\">10.1111/cod.14287</a>, ."},"publisher":"Wiley","quality_controlled":"1","intvolume":"        88"}]