[{"_id":"598","keyword":["Additive manufacturing","topology optimization","aerospace","life cycle costs"],"corporate_editor":["Department of Production Engineering and Management","Hochschule Ostwestfalen-Lippe"],"related_material":{"link":[{"url":"https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_Tagung_zusammen2015.pdf","relation":"contains"}]},"publication_identifier":{"isbn":["978-3-941645-11-0"]},"place":"Lemgo","status":"public","page":"207-218","oa":"1","citation":{"bjps":"<b>Huxol A and Villmer F-J</b> (2015) Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In Padoano E, Villmer F-J and Department of Production Engineering and Management (eds), <i>Production Engineering and Management</i>. Lemgo, pp. 207–218.","ieee":"A. Huxol and F.-J. Villmer, “Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies,” in <i>Production Engineering and Management</i>, Trieste, Italy, 2015, no. 1, pp. 207–218.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Huxol, Andrea</span> ; <span style=\"font-variant:small-caps;\">Villmer, Franz-Josef</span>: Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In: <span style=\"font-variant:small-caps;\">Padoano, E.</span> ; <span style=\"font-variant:small-caps;\">Villmer, F.-J.</span> ; <span style=\"font-variant:small-caps;\">Department of Production Engineering and Management</span> (Hrsg.): <i>Production Engineering and Management</i>. Lemgo, 2015, S. 207–218","havard":"A. Huxol, F.-J. Villmer, Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies, in: E. Padoano, F.-J. Villmer, Department of Production Engineering and Management (Eds.), Production Engineering and Management, Lemgo, 2015: pp. 207–218.","short":"A. Huxol, F.-J. Villmer, in: E. Padoano, F.-J. Villmer, Department of Production Engineering and Management (Eds.), Production Engineering and Management, Lemgo, 2015, pp. 207–218.","van":"Huxol A, Villmer F-J. Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In: Padoano E, Villmer F-J, Department of Production Engineering and Management, editors. Production Engineering and Management. Lemgo; 2015. p. 207–18.","mla":"Huxol, Andrea, and Franz-Josef Villmer. “Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies.” <i>Production Engineering and Management</i>, edited by Elio Padoano et al., no. 1, 2015, pp. 207–18.","apa":"Huxol, A., &#38; Villmer, F.-J. (2015). Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In E. Padoano, F.-J. Villmer, &#38; Department of Production Engineering and Management (Eds.), <i>Production Engineering and Management</i> (pp. 207–218). Lemgo.","ufg":"<b>Huxol, Andrea/Villmer, Franz-Josef (2015)</b>: Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies, in: Elio Padoano et. al. (Hgg.): <i>Production Engineering and Management</i>, Lemgo, S. 207–218.","ama":"Huxol A, Villmer F-J. Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In: Padoano E, Villmer F-J, Department of Production Engineering and Management, eds. <i>Production Engineering and Management</i>. Lemgo; 2015:207-218.","chicago-de":"Huxol, Andrea und Franz-Josef Villmer. 2015. Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In: <i>Production Engineering and Management</i>, hg. von Elio Padoano, Franz-Josef Villmer, und Department of Production Engineering and Management, 207–218. Lemgo.","chicago":"Huxol, Andrea, and Franz-Josef Villmer. “Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies.” In <i>Production Engineering and Management</i>, edited by Elio Padoano, Franz-Josef Villmer, and Department of Production Engineering and Management, 207–18. Lemgo, 2015."},"main_file_link":[{"open_access":"1","url":"https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_Tagung_zusammen2015.pdf"}],"publication_status":"published","user_id":"45673","type":"conference","conference":{"end_date":"2015-10-02","name":"Proceedings5th International Conference","start_date":"2015-10-01","location":"Trieste, Italy"},"date_updated":"2023-03-15T13:50:03Z","abstract":[{"text":"The aerospace sector is characterized by long product life cycles and a need for lightweight design. Additive manufacturing is a technology that produces parts layer by layer and thus enables the manufacturing of any complex parts at nearly no extra costs. A topology optimization enhances the part’s\r\nperformance for their special purpose. The results are often complex bionic structures that cannot be produced with conventional manufacturing technologies. The paper analyzes how the high potential of this technologycan be applied to aerospace parts. A topology optimization will be conducted for an aircraft part explaining the crucial points and a life cycle analysis examines the achieved sustainable improvements for the aircraft’s life cycle.\r\n","lang":"eng"}],"date_created":"2019-02-19T07:26:35Z","issue":"1","title":"Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies","author":[{"full_name":"Huxol, Andrea","id":"43559","first_name":"Andrea","last_name":"Huxol"},{"id":"14290","first_name":"Franz-Josef","last_name":"Villmer","full_name":"Villmer, Franz-Josef"}],"editor":[{"last_name":"Padoano","first_name":"Elio","full_name":"Padoano, Elio"},{"full_name":"Villmer, Franz-Josef","last_name":"Villmer","first_name":"Franz-Josef"}],"year":2015,"publication":"Production Engineering and Management","language":[{"iso":"eng"}],"department":[{"_id":"DEP1306"}]},{"type":"book_chapter","user_id":"74004","volume":1104,"doi":"10.1007/978-1-62703-733-4_22","intvolume":"      1104","series_title":"Methods in Molecular Biology ","date_updated":"2023-03-15T13:49:39Z","publisher":"Humana Press","abstract":[{"lang":"eng","text":"For the production of biopharmaceuticals a seed train is required to generate an adequate number of cells for inoculation of the production bioreactor. This seed train is time- and cost-intensive but offers potential for optimization. A method and a protocol are described for the seed train mapping, directed modeling without major effort, and its optimization regarding selected optimization criteria such as optimal points in time for cell passaging. Furthermore, the method can also be applied for the set-up of a new seed train, for example for a new cell line. Although the chapter is directed towards suspension cell lines, the method is also generally applicable, e.g. for adherent cell lines."}],"date_created":"2020-05-19T14:45:43Z","year":2013,"publication":"Animal Cell Biotechnology","language":[{"iso":"eng"}],"department":[{"_id":"DEP4021"}],"title":"Seed Train Optimization for Cell Culture","author":[{"first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn"}],"_id":"2394","keyword":["Seed train Optimization Modeling Prediction Space-Time-Yield (STY) Systems approach Bioinformatics Computational biotechnology Suspension Production"],"publication_identifier":{"issn":["1064-3745","1940-6029"],"isbn":["9781627037327"],"eisbn":["9781627037334"]},"status":"public","place":"Totowa, NJ","citation":{"short":"B. Frahm, in: Animal Cell Biotechnology, Humana Press, Totowa, NJ, 2013, pp. 355–367.","mla":"Frahm, Björn. “Seed Train Optimization for Cell Culture.” <i>Animal Cell Biotechnology</i>, vol. 1104, Humana Press, 2013, pp. 355–67, doi:<a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">10.1007/978-1-62703-733-4_22</a>.","van":"Frahm B. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology. Totowa, NJ: Humana Press; 2013. p. 355–67. (Methods in Molecular Biology ; vol. 1104).","apa":"Frahm, B. (2013). Seed Train Optimization for Cell Culture. In <i>Animal Cell Biotechnology</i> (Vol. 1104, pp. 355–367). Totowa, NJ: Humana Press. <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">https://doi.org/10.1007/978-1-62703-733-4_22</a>","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Seed Train Optimization for Cell Culture. In: <i>Animal Cell Biotechnology</i>, <i>Methods in Molecular Biology </i>. Bd. 1104. Totowa, NJ : Humana Press, 2013, S. 355–367","havard":"B. Frahm, Seed Train Optimization for Cell Culture, in: Animal Cell Biotechnology, Humana Press, Totowa, NJ, 2013: pp. 355–367.","bjps":"<b>Frahm B</b> (2013) Seed Train Optimization for Cell Culture. <i>Animal Cell Biotechnology</i>, vol. 1104. Totowa, NJ: Humana Press, pp. 355–367.","ieee":"B. Frahm, “Seed Train Optimization for Cell Culture,” in <i>Animal Cell Biotechnology</i>, vol. 1104, Totowa, NJ: Humana Press, 2013, pp. 355–367.","chicago":"Frahm, Björn. “Seed Train Optimization for Cell Culture.” In <i>Animal Cell Biotechnology</i>, 1104:355–67. Methods in Molecular Biology . Totowa, NJ: Humana Press, 2013. <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">https://doi.org/10.1007/978-1-62703-733-4_22</a>.","chicago-de":"Frahm, Björn. 2013. Seed Train Optimization for Cell Culture. In: <i>Animal Cell Biotechnology</i>, 1104:355–367. Methods in Molecular Biology . Totowa, NJ: Humana Press. doi:<a href=\"https://doi.org/10.1007/978-1-62703-733-4_22,\">10.1007/978-1-62703-733-4_22,</a> .","ama":"Frahm B. Seed Train Optimization for Cell Culture. In: <i>Animal Cell Biotechnology</i>. Vol 1104. Methods in Molecular Biology . Totowa, NJ: Humana Press; 2013:355-367. doi:<a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">10.1007/978-1-62703-733-4_22</a>","ufg":"<b>Frahm, Björn (2013)</b>: Seed Train Optimization for Cell Culture, in: <i>Animal Cell Biotechnology</i> (=<i>Methods in Molecular Biology  1104</i>), Totowa, NJ, S. 355–367."},"page":"355-367","publication_status":"published"},{"publication_identifier":{"issn":["1064-3745"],"eissn":["1940-6029"],"isbn":["978-1-62703-732-7"],"eisbn":["978-1-62703-733-4"]},"_id":"10214","keyword":["Seed train","Optimization","Modeling","Prediction","Space-Time-Yield (STY)","Systems approach","Bioinformatics","Computational biotechnology","Suspension","Production"],"publication_status":"published","edition":"3","status":"public","place":"Totowa, NJ","citation":{"ufg":"<b>Frahm, Björn</b>: Seed Train Optimization for Cell Culture, in: <i>Pörtner, Ralf (Hg.)</i>: Animal Cell Biotechnology - Methods and Protocols, Bd. 1104, Totowa, NJ <sup>3</sup>2013 (Methods in Molecular Biology),  S. 355–367.","ama":"Frahm B. Seed Train Optimization for Cell Culture. In: Pörtner R, ed. <i>Animal Cell Biotechnology - Methods and Protocols</i>. Vol 1104. 3rd ed. Methods in Molecular Biology. Humana Press; 2013:355-367. doi:<a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">10.1007/978-1-62703-733-4_22</a>","chicago-de":"Frahm, Björn. 2013. Seed Train Optimization for Cell Culture. In: <i>Animal Cell Biotechnology - Methods and Protocols</i>, hg. von Ralf Pörtner, 1104:355–367. 3. Aufl. Methods in Molecular Biology. Totowa, NJ: Humana Press. doi:<a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">10.1007/978-1-62703-733-4_22</a>, .","chicago":"Frahm, Björn. “Seed Train Optimization for Cell Culture.” In <i>Animal Cell Biotechnology - Methods and Protocols</i>, edited by Ralf Pörtner, 3rd ed., 1104:355–67. Methods in Molecular Biology. Totowa, NJ: Humana Press, 2013. <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">https://doi.org/10.1007/978-1-62703-733-4_22</a>.","ieee":"B. Frahm, “Seed Train Optimization for Cell Culture,” in <i>Animal Cell Biotechnology - Methods and Protocols</i>, 3rd ed., vol. 1104, R. Pörtner, Ed. Totowa, NJ: Humana Press, 2013, pp. 355–367. doi: <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">10.1007/978-1-62703-733-4_22</a>.","bjps":"<b>Frahm B</b> (2013) Seed Train Optimization for Cell Culture. In Pörtner R (ed.), <i>Animal Cell Biotechnology - Methods and Protocols</i>, 3rd ed., vol. 1104. Totowa, NJ: Humana Press, pp. 355–367.","havard":"B. Frahm, Seed Train Optimization for Cell Culture, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013: pp. 355–367.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Seed Train Optimization for Cell Culture. In: <span style=\"font-variant:small-caps;\">Pörtner, R.</span> (Hrsg.): <i>Animal Cell Biotechnology - Methods and Protocols</i>, <i>Methods in Molecular Biology</i>. Bd. 1104. 3. Aufl. Totowa, NJ : Humana Press, 2013, S. 355–367","mla":"Frahm, Björn. “Seed Train Optimization for Cell Culture.” <i>Animal Cell Biotechnology - Methods and Protocols</i>, edited by Ralf Pörtner, 3rd ed., vol. 1104, Humana Press, 2013, pp. 355–67, <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">https://doi.org/10.1007/978-1-62703-733-4_22</a>.","apa":"Frahm, B. (2013). Seed Train Optimization for Cell Culture. In R. Pörtner (Ed.), <i>Animal Cell Biotechnology - Methods and Protocols</i> (3rd ed., Vol. 1104, pp. 355–367). Humana Press. <a href=\"https://doi.org/10.1007/978-1-62703-733-4_22\">https://doi.org/10.1007/978-1-62703-733-4_22</a>","van":"Frahm B. Seed Train Optimization for Cell Culture. In: Pörtner R, editor. Animal Cell Biotechnology - Methods and Protocols. 3rd ed. Totowa, NJ: Humana Press; 2013. p. 355–67. (Methods in Molecular Biology; vol. 1104).","short":"B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013, pp. 355–367."},"page":"355–367","intvolume":"      1104","series_title":"Methods in Molecular Biology","date_updated":"2023-08-16T06:41:21Z","type":"book_chapter","user_id":"83781","doi":"10.1007/978-1-62703-733-4_22","volume":1104,"publication":"Animal Cell Biotechnology - Methods and Protocols","year":"2013","language":[{"iso":"eng"}],"department":[{"_id":"DEP4000"}],"title":"Seed Train Optimization for Cell Culture","author":[{"last_name":"Frahm","first_name":"Björn","id":"45666","full_name":"Frahm, Björn"}],"editor":[{"last_name":"Pörtner","first_name":"Ralf","full_name":"Pörtner, Ralf"}],"publisher":"Humana Press","abstract":[{"text":"For the production of biopharmaceuticals a seed train is required to generate an adequate number of cells for inoculation of the production bioreactor. This seed train is time- and cost-intensive but offers potential for optimization. A method and a protocol are described for the seed train mapping, directed modeling without major effort, and its optimization regarding selected optimization criteria such as optimal points in time for cell passaging. Furthermore, the method can also be applied for the set-up of a new seed train, for example for a new cell line. Although the chapter is directed towards suspension cell lines, the method is also generally applicable, e.g. for adherent cell lines.","lang":"eng"}],"date_created":"2023-08-14T17:50:56Z"}]