---
_id: '457'
abstract:
- lang: eng
text: "Additive Manufacturing (AM) increasingly enables the realization of structures,
which have a much greater freedom of design und can therefore better use nature
\ as a design ideal. Bionic design principles have already been introduced
\ into general design approaches, and several topology optimization systems
(TO) are available today to increase structural stiffness and to enable lightweight
\ design. AM and TO, used in synergy, promise completely new application
areas. However, staircase effects resulting from a layer-by-layer build process
\ and unavoidable support structures which must be mechanically removed afterwards
are disadvantageous with respect to surface texture and strength properties.\r\nThe
present article addresses the question of how far the notches resulting from
the staircase effect of Additive Manufacturing and the support structures removed
\ decrease the strength of components. Most engineers try to follow the
inner flow of forces in a part’s design by smoothening surfaces in notched areas.
Considering this, a elected component is investigated with finite element
\ analysis (FEA) with special regard for the concentration of tress arising
from surface notch effects. An outlook is given as regards how a reduction of
the notch effect from the taircase effect can be achieved effectively."
author:
- first_name: Eva
full_name: Scheideler, Eva
id: '61522'
last_name: Scheideler
- first_name: Franz-Josef
full_name: Villmer, Franz-Josef
id: '14290'
last_name: Villmer
- first_name: G.
full_name: Adam, G.
last_name: Adam
- first_name: Mirco
full_name: Timmer, Mirco
id: '69228'
last_name: Timmer
conference:
end_date: 2016-09-30
location: Lemgo
name: Proceedings 6th International Conference
start_date: 2016-09-29
corporate_editor:
- Department of Production Engineering and Management OWL University of Applied Sciences,
Lemgo (Germany)
- Hochschule Ostwestfalen-Lippe
date_created: 2019-01-22T14:07:32Z
date_updated: 2023-03-15T13:49:54Z
department:
- _id: DEP1306
editor:
- first_name: Franz-Josef
full_name: Villmer, Franz-Josef
id: '14290'
last_name: Villmer
- first_name: Elio
full_name: Padoano, Elio
last_name: Padoano
issue: '1'
keyword:
- Additive Manufacturing
- Topology optimization
- Staircase effect
- Support structures
- Stress concentration
- Lightweight construction
- Design rules
- Notch effect
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.th-owl.de/elsa/download/333/334/PEM_2016_Proceeding_2016_09_14_Inhaltsnavigation.pdf
oa: '1'
page: 39-50
place: Lemgo
publication: Production Engineering and Management Proceedings 6th International Conference
publication_identifier:
isbn:
- 978-3-946856-00-9
publication_status: published
status: public
title: Topology Optimization and Additive Manufacturing – A Perfect Symbiosis?
type: conference
user_id: '79260'
year: 2016
...
---
_id: '598'
abstract:
- lang: eng
text: "The aerospace sector is characterized by long product life cycles and a need
for lightweight design. Additive manufacturing is a technology that produces parts
layer by layer and thus enables the manufacturing of any complex parts at nearly
no extra costs. A topology optimization enhances the part’s\r\nperformance for
their special purpose. The results are often complex bionic structures that cannot
be produced with conventional manufacturing technologies. The paper analyzes how
the high potential of this technologycan be applied to aerospace parts. A topology
optimization will be conducted for an aircraft part explaining the crucial points
and a life cycle analysis examines the achieved sustainable improvements for the
aircraft’s life cycle.\r\n"
author:
- first_name: Andrea
full_name: Huxol, Andrea
id: '43559'
last_name: Huxol
- first_name: Franz-Josef
full_name: Villmer, Franz-Josef
id: '14290'
last_name: Villmer
citation:
ama: 'Huxol A, Villmer F-J. Hybrid Manufacturing Machines: Combining Additive and
Subtractive Manufacturing Technologies. In: Padoano E, Villmer F-J, Department
of Production Engineering and Management, eds. Production Engineering and Management.
Lemgo; 2015:207-218.'
apa: 'Huxol, A., & Villmer, F.-J. (2015). Hybrid Manufacturing Machines: Combining
Additive and Subtractive Manufacturing Technologies. In E. Padoano, F.-J. Villmer,
& Department of Production Engineering and Management (Eds.), Production
Engineering and Management (pp. 207–218). Lemgo.'
bjps: 'Huxol A and Villmer F-J (2015) Hybrid Manufacturing Machines: Combining
Additive and Subtractive Manufacturing Technologies. In Padoano E, Villmer F-J
and Department of Production Engineering and Management (eds), Production Engineering
and Management. Lemgo, pp. 207–218.'
chicago: 'Huxol, Andrea, and Franz-Josef Villmer. “Hybrid Manufacturing Machines:
Combining Additive and Subtractive Manufacturing Technologies.” In Production
Engineering and Management, edited by Elio Padoano, Franz-Josef Villmer, and
Department of Production Engineering and Management, 207–18. Lemgo, 2015.'
chicago-de: 'Huxol, Andrea und Franz-Josef Villmer. 2015. Hybrid Manufacturing Machines:
Combining Additive and Subtractive Manufacturing Technologies. In: Production
Engineering and Management, hg. von Elio Padoano, Franz-Josef Villmer, und
Department of Production Engineering and Management, 207–218. Lemgo.'
din1505-2-1: 'Huxol, Andrea ; Villmer, Franz-Josef: Hybrid Manufacturing
Machines: Combining Additive and Subtractive Manufacturing Technologies. In: Padoano, E. ; Villmer,
F.-J. ; Department of Production
Engineering and Management (Hrsg.): Production Engineering and Management.
Lemgo, 2015, S. 207–218'
havard: 'A. Huxol, F.-J. Villmer, Hybrid Manufacturing Machines: Combining Additive
and Subtractive Manufacturing Technologies, in: E. Padoano, F.-J. Villmer, Department
of Production Engineering and Management (Eds.), Production Engineering and Management,
Lemgo, 2015: pp. 207–218.'
ieee: 'A. Huxol and F.-J. Villmer, “Hybrid Manufacturing Machines: Combining Additive
and Subtractive Manufacturing Technologies,” in Production Engineering and
Management, Trieste, Italy, 2015, no. 1, pp. 207–218.'
mla: 'Huxol, Andrea, and Franz-Josef Villmer. “Hybrid Manufacturing Machines: Combining
Additive and Subtractive Manufacturing Technologies.” Production Engineering
and Management, edited by Elio Padoano et al., no. 1, 2015, pp. 207–18.'
short: 'A. Huxol, F.-J. Villmer, in: E. Padoano, F.-J. Villmer, Department of Production
Engineering and Management (Eds.), Production Engineering and Management, Lemgo,
2015, pp. 207–218.'
ufg: 'Huxol, Andrea/Villmer, Franz-Josef (2015): Hybrid Manufacturing Machines:
Combining Additive and Subtractive Manufacturing Technologies, in: Elio Padoano
et. al. (Hgg.): Production Engineering and Management, Lemgo, S. 207–218.'
van: 'Huxol A, Villmer F-J. Hybrid Manufacturing Machines: Combining Additive and
Subtractive Manufacturing Technologies. In: Padoano E, Villmer F-J, Department
of Production Engineering and Management, editors. Production Engineering and
Management. Lemgo; 2015. p. 207–18.'
conference:
end_date: 2015-10-02
location: Trieste, Italy
name: Proceedings5th International Conference
start_date: 2015-10-01
corporate_editor:
- Department of Production Engineering and Management
- Hochschule Ostwestfalen-Lippe
date_created: 2019-02-19T07:26:35Z
date_updated: 2023-03-15T13:50:03Z
department:
- _id: DEP1306
editor:
- first_name: Elio
full_name: Padoano, Elio
last_name: Padoano
- first_name: Franz-Josef
full_name: Villmer, Franz-Josef
last_name: Villmer
issue: '1'
keyword:
- Additive manufacturing
- topology optimization
- aerospace
- life cycle costs
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_Tagung_zusammen2015.pdf
oa: '1'
page: 207-218
place: Lemgo
publication: Production Engineering and Management
publication_identifier:
isbn:
- 978-3-941645-11-0
publication_status: published
related_material:
link:
- relation: contains
url: https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_Tagung_zusammen2015.pdf
status: public
title: 'Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing
Technologies'
type: conference
user_id: '45673'
year: 2015
...
---
_id: '2394'
abstract:
- lang: eng
text: For the production of biopharmaceuticals a seed train is required to generate
an adequate number of cells for inoculation of the production bioreactor. This
seed train is time- and cost-intensive but offers potential for optimization.
A method and a protocol are described for the seed train mapping, directed modeling
without major effort, and its optimization regarding selected optimization criteria
such as optimal points in time for cell passaging. Furthermore, the method can
also be applied for the set-up of a new seed train, for example for a new cell
line. Although the chapter is directed towards suspension cell lines, the method
is also generally applicable, e.g. for adherent cell lines.
author:
- first_name: Björn
full_name: Frahm, Björn
last_name: Frahm
citation:
ama: 'Frahm B. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology.
Vol 1104. Methods in Molecular Biology . Totowa, NJ: Humana Press; 2013:355-367.
doi:10.1007/978-1-62703-733-4_22'
apa: 'Frahm, B. (2013). Seed Train Optimization for Cell Culture. In Animal Cell
Biotechnology (Vol. 1104, pp. 355–367). Totowa, NJ: Humana Press. https://doi.org/10.1007/978-1-62703-733-4_22'
bjps: 'Frahm B (2013) Seed Train Optimization for Cell Culture. Animal
Cell Biotechnology, vol. 1104. Totowa, NJ: Humana Press, pp. 355–367.'
chicago: 'Frahm, Björn. “Seed Train Optimization for Cell Culture.” In Animal
Cell Biotechnology, 1104:355–67. Methods in Molecular Biology . Totowa, NJ:
Humana Press, 2013. https://doi.org/10.1007/978-1-62703-733-4_22.'
chicago-de: 'Frahm, Björn. 2013. Seed Train Optimization for Cell Culture. In: Animal
Cell Biotechnology, 1104:355–367. Methods in Molecular Biology . Totowa, NJ:
Humana Press. doi:10.1007/978-1-62703-733-4_22,
.'
din1505-2-1: 'Frahm, Björn: Seed Train
Optimization for Cell Culture. In: Animal Cell Biotechnology, Methods
in Molecular Biology . Bd. 1104. Totowa, NJ : Humana Press, 2013, S. 355–367'
havard: 'B. Frahm, Seed Train Optimization for Cell Culture, in: Animal Cell Biotechnology,
Humana Press, Totowa, NJ, 2013: pp. 355–367.'
ieee: 'B. Frahm, “Seed Train Optimization for Cell Culture,” in Animal Cell Biotechnology,
vol. 1104, Totowa, NJ: Humana Press, 2013, pp. 355–367.'
mla: Frahm, Björn. “Seed Train Optimization for Cell Culture.” Animal Cell Biotechnology,
vol. 1104, Humana Press, 2013, pp. 355–67, doi:10.1007/978-1-62703-733-4_22.
short: 'B. Frahm, in: Animal Cell Biotechnology, Humana Press, Totowa, NJ, 2013,
pp. 355–367.'
ufg: 'Frahm, Björn (2013): Seed Train Optimization for Cell Culture, in:
Animal Cell Biotechnology (=Methods in Molecular Biology 1104),
Totowa, NJ, S. 355–367.'
van: 'Frahm B. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology.
Totowa, NJ: Humana Press; 2013. p. 355–67. (Methods in Molecular Biology ; vol.
1104).'
date_created: 2020-05-19T14:45:43Z
date_updated: 2023-03-15T13:49:39Z
department:
- _id: DEP4021
doi: 10.1007/978-1-62703-733-4_22
intvolume: ' 1104'
keyword:
- Seed train Optimization Modeling Prediction Space-Time-Yield (STY) Systems approach
Bioinformatics Computational biotechnology Suspension Production
language:
- iso: eng
page: 355-367
place: Totowa, NJ
publication: Animal Cell Biotechnology
publication_identifier:
eisbn:
- '9781627037334'
isbn:
- '9781627037327'
issn:
- 1064-3745
- 1940-6029
publication_status: published
publisher: Humana Press
series_title: 'Methods in Molecular Biology '
status: public
title: Seed Train Optimization for Cell Culture
type: book_chapter
user_id: '74004'
volume: 1104
year: 2013
...
---
_id: '10214'
abstract:
- lang: eng
text: For the production of biopharmaceuticals a seed train is required to generate
an adequate number of cells for inoculation of the production bioreactor. This
seed train is time- and cost-intensive but offers potential for optimization.
A method and a protocol are described for the seed train mapping, directed modeling
without major effort, and its optimization regarding selected optimization criteria
such as optimal points in time for cell passaging. Furthermore, the method can
also be applied for the set-up of a new seed train, for example for a new cell
line. Although the chapter is directed towards suspension cell lines, the method
is also generally applicable, e.g. for adherent cell lines.
author:
- first_name: Björn
full_name: Frahm, Björn
id: '45666'
last_name: Frahm
citation:
ama: 'Frahm B. Seed Train Optimization for Cell Culture. In: Pörtner R, ed. Animal
Cell Biotechnology - Methods and Protocols. Vol 1104. 3rd ed. Methods in Molecular
Biology. Humana Press; 2013:355-367. doi:10.1007/978-1-62703-733-4_22'
apa: Frahm, B. (2013). Seed Train Optimization for Cell Culture. In R. Pörtner (Ed.),
Animal Cell Biotechnology - Methods and Protocols (3rd ed., Vol. 1104,
pp. 355–367). Humana Press. https://doi.org/10.1007/978-1-62703-733-4_22
bjps: 'Frahm B (2013) Seed Train Optimization for Cell Culture. In Pörtner
R (ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., vol.
1104. Totowa, NJ: Humana Press, pp. 355–367.'
chicago: 'Frahm, Björn. “Seed Train Optimization for Cell Culture.” In Animal
Cell Biotechnology - Methods and Protocols, edited by Ralf Pörtner, 3rd ed.,
1104:355–67. Methods in Molecular Biology. Totowa, NJ: Humana Press, 2013. https://doi.org/10.1007/978-1-62703-733-4_22.'
chicago-de: 'Frahm, Björn. 2013. Seed Train Optimization for Cell Culture. In: Animal
Cell Biotechnology - Methods and Protocols, hg. von Ralf Pörtner, 1104:355–367.
3. Aufl. Methods in Molecular Biology. Totowa, NJ: Humana Press. doi:10.1007/978-1-62703-733-4_22,
.'
din1505-2-1: 'Frahm, Björn: Seed Train
Optimization for Cell Culture. In: Pörtner,
R. (Hrsg.): Animal Cell Biotechnology - Methods and Protocols, Methods
in Molecular Biology. Bd. 1104. 3. Aufl. Totowa, NJ : Humana Press, 2013,
S. 355–367'
havard: 'B. Frahm, Seed Train Optimization for Cell Culture, in: R. Pörtner (Ed.),
Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa,
NJ, 2013: pp. 355–367.'
ieee: 'B. Frahm, “Seed Train Optimization for Cell Culture,” in Animal Cell Biotechnology
- Methods and Protocols, 3rd ed., vol. 1104, R. Pörtner, Ed. Totowa, NJ: Humana
Press, 2013, pp. 355–367. doi: 10.1007/978-1-62703-733-4_22.'
mla: Frahm, Björn. “Seed Train Optimization for Cell Culture.” Animal Cell Biotechnology
- Methods and Protocols, edited by Ralf Pörtner, 3rd ed., vol. 1104, Humana
Press, 2013, pp. 355–67, https://doi.org/10.1007/978-1-62703-733-4_22.
short: 'B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and
Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013, pp. 355–367.'
ufg: 'Frahm, Björn: Seed Train Optimization for Cell Culture, in: Pörtner,
Ralf (Hg.): Animal Cell Biotechnology - Methods and Protocols, Bd. 1104, Totowa,
NJ 32013 (Methods in Molecular Biology), S. 355–367.'
van: 'Frahm B. Seed Train Optimization for Cell Culture. In: Pörtner R, editor.
Animal Cell Biotechnology - Methods and Protocols. 3rd ed. Totowa, NJ: Humana
Press; 2013. p. 355–67. (Methods in Molecular Biology; vol. 1104).'
date_created: 2023-08-14T17:50:56Z
date_updated: 2023-08-16T06:41:21Z
department:
- _id: DEP4000
doi: 10.1007/978-1-62703-733-4_22
edition: '3'
editor:
- first_name: Ralf
full_name: Pörtner, Ralf
last_name: Pörtner
intvolume: ' 1104'
keyword:
- Seed train
- Optimization
- Modeling
- Prediction
- Space-Time-Yield (STY)
- Systems approach
- Bioinformatics
- Computational biotechnology
- Suspension
- Production
language:
- iso: eng
page: 355–367
place: Totowa, NJ
publication: Animal Cell Biotechnology - Methods and Protocols
publication_identifier:
eisbn:
- 978-1-62703-733-4
eissn:
- 1940-6029
isbn:
- 978-1-62703-732-7
issn:
- 1064-3745
publication_status: published
publisher: Humana Press
series_title: Methods in Molecular Biology
status: public
title: Seed Train Optimization for Cell Culture
type: book_chapter
user_id: '83781'
volume: 1104
year: '2013'
...