--- _id: '13271' abstract: - lang: eng text: Pasteurization is the prevalent method for stabilizing cloudy apple juice and prolonging its shelf life, but can also impair quality. Therefore, it is necessary to investigate and quantify the chemical, physical and sensory effects of this treatment. In this study, cloudy apple juice was treated at different time-temperature combinations with equivalent microbial lethality with 161.6 PU. These can be categorized as low temperature/long time (LTLT with 70°C and 80°C) or high temperature/short time (HTST with 90°C, 100°C and 105°C) treatments. The results were compared to those of untreated juice. HTST treatment had significantly less impact on the juice compared to LTLT treatment. LTLT-treated juices were characterized by different sensory attributes, such as raisin and caramel odor and bitter taste. In contrast, the untreated and HTST-treated juices exhibited odors like pear and lemon. There were also significant differences in turbidity, sugar composition, viscosity and a heightened 5-(hydroxymethyl)furfural (HMF) content with LTLT treatment. In summary, HTST-treated juices are more similar to the untreated juices and are rated higher in terms of quality characteristics. The lowest pasteurization temperature of 70°C results in the greatest deterioration of juice quality. It can be concluded that different pasteurization conditions showed different effects on juice quality, despite having the same microbiological lethality of 161.6 PU. Results can be considered when designing pasteurization processes. article_number: '101471' author: - first_name: Linda full_name: Katsch, Linda id: '71614' last_name: Katsch orcid: '0000-0001-6628-3929 ' - first_name: Martina full_name: Sokolowsky, Martina id: '76708' last_name: Sokolowsky - first_name: Brian full_name: Gibson, Brian last_name: Gibson - first_name: Jan full_name: Schneider, Jan id: '13209' last_name: Schneider orcid: 0000-0001-6401-8873 citation: ama: Katsch L, Sokolowsky M, Gibson B, Schneider J. Influence of different pasteurization conditions with equivalent pasteurization units on chemical, physical, and sensory properties of cloudy apple juice. Applied Food Research. 2025;5(2). doi:10.1016/j.afres.2025.101471 apa: Katsch, L., Sokolowsky, M., Gibson, B., & Schneider, J. (2025). Influence of different pasteurization conditions with equivalent pasteurization units on chemical, physical, and sensory properties of cloudy apple juice. Applied Food Research, 5(2), Article 101471. https://doi.org/10.1016/j.afres.2025.101471 bjps: Katsch L et al. (2025) Influence of Different Pasteurization Conditions with Equivalent Pasteurization Units on Chemical, Physical, and Sensory Properties of Cloudy Apple Juice. Applied Food Research 5. chicago: Katsch, Linda, Martina Sokolowsky, Brian Gibson, and Jan Schneider. “Influence of Different Pasteurization Conditions with Equivalent Pasteurization Units on Chemical, Physical, and Sensory Properties of Cloudy Apple Juice.” Applied Food Research 5, no. 2 (2025). https://doi.org/10.1016/j.afres.2025.101471. chicago-de: Katsch, Linda, Martina Sokolowsky, Brian Gibson und Jan Schneider. 2025. Influence of different pasteurization conditions with equivalent pasteurization units on chemical, physical, and sensory properties of cloudy apple juice. Applied Food Research 5, Nr. 2. doi:10.1016/j.afres.2025.101471, . din1505-2-1: 'Katsch, Linda ; Sokolowsky, Martina ; Gibson, Brian ; Schneider, Jan: Influence of different pasteurization conditions with equivalent pasteurization units on chemical, physical, and sensory properties of cloudy apple juice. In: Applied Food Research Bd. 5. Amsterdam, Elsevier (2025), Nr. 2' havard: L. Katsch, M. Sokolowsky, B. Gibson, J. Schneider, Influence of different pasteurization conditions with equivalent pasteurization units on chemical, physical, and sensory properties of cloudy apple juice, Applied Food Research. 5 (2025). ieee: 'L. Katsch, M. Sokolowsky, B. Gibson, and J. Schneider, “Influence of different pasteurization conditions with equivalent pasteurization units on chemical, physical, and sensory properties of cloudy apple juice,” Applied Food Research, vol. 5, no. 2, Art. no. 101471, 2025, doi: 10.1016/j.afres.2025.101471.' mla: Katsch, Linda, et al. “Influence of Different Pasteurization Conditions with Equivalent Pasteurization Units on Chemical, Physical, and Sensory Properties of Cloudy Apple Juice.” Applied Food Research, vol. 5, no. 2, 101471, 2025, https://doi.org/10.1016/j.afres.2025.101471. short: L. Katsch, M. Sokolowsky, B. Gibson, J. Schneider, Applied Food Research 5 (2025). ufg: 'Katsch, Linda u. a.: Influence of different pasteurization conditions with equivalent pasteurization units on chemical, physical, and sensory properties of cloudy apple juice, in: Applied Food Research 5 (2025), H. 2.' van: Katsch L, Sokolowsky M, Gibson B, Schneider J. Influence of different pasteurization conditions with equivalent pasteurization units on chemical, physical, and sensory properties of cloudy apple juice. Applied Food Research. 2025;5(2). date_created: 2025-10-27T16:10:29Z date_updated: 2025-11-05T08:17:40Z department: - _id: DEP4023 - _id: DEP4018 doi: 10.1016/j.afres.2025.101471 intvolume: ' 5' issue: '2' keyword: - Cloudy apple juice - HTST - juice pasteurization - sensory analysis - process optimization - equivalent microbial lethality language: - iso: eng place: Amsterdam publication: Applied Food Research publication_identifier: eissn: - 2772-5022 publication_status: published publisher: Elsevier quality_controlled: '1' status: public title: Influence of different pasteurization conditions with equivalent pasteurization units on chemical, physical, and sensory properties of cloudy apple juice type: scientific_journal_article user_id: '83781' volume: 5 year: '2025' ... --- _id: '13433' abstract: - lang: eng text: The use of lubricants on electrical connector contacts is essential for certain applications in order to reduce mating forces, minimize wear, and mitigate fretting corrosion. However, increasing performance requirements (e.g., operation at elevated temperatures) and regulatory restrictions are prompting a reassessment of lubricant selection. In this study, the influence of three lubricants (one oil and two greases), operating temperature (room temperature and 130°C), and applied volume (low, medium and high volume) on electrical contact resistance (ECR) and coefficient of friction (CoF) is investigated by means of fretting wear tests on silver-plated contacts. The results show that unlubricated silver contacts exhibit a longer stable phase at 130 °C than at room temperature. For lubricated contacts, service life is influenced by both temperature and lubricant volume. Certain lubricants demonstrate earlier fail at room temperature than at elevated temperatures. The findings highlight the importance of careful selection and optimization of lubricants for electrical connectors under varying environmental conditions. author: - first_name: Michael full_name: Blauth, Michael id: '49095' last_name: Blauth - first_name: Sören full_name: Tülling, Sören id: '71422' last_name: Tülling - first_name: Jian full_name: Song, Jian id: '5297' last_name: Song citation: ama: Blauth M, Tülling S, Song J. Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts. (ieee-holm, ed.). IEEE; 2025. doi:10.1109/hlm51652.2025.11278329 apa: Blauth, M., Tülling, S., & Song, J. (2025). Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts. In ieee-holm (Ed.), Proceedings of the 70th IEEE Holm Conference on Electrical Contacts (HLM). IEEE. https://doi.org/10.1109/hlm51652.2025.11278329 bjps: 'Blauth M, Tülling S and Song J (2025) Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts, ieee-holm (ed.). Piscataway, NJ: IEEE.' chicago: 'Blauth, Michael, Sören Tülling, and Jian Song. Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts. Edited by ieee-holm. Proceedings of the 70th IEEE Holm Conference on Electrical Contacts (HLM). Electrical Contacts. Piscataway, NJ: IEEE, 2025. https://doi.org/10.1109/hlm51652.2025.11278329.' chicago-de: 'Blauth, Michael, Sören Tülling und Jian Song. 2025. Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts. Hg. von ieee-holm. Proceedings of the 70th IEEE Holm Conference on Electrical Contacts (HLM). Electrical contacts. Piscataway, NJ: IEEE. doi:10.1109/hlm51652.2025.11278329, .' din1505-2-1: 'Blauth, Michael ; Tülling, Sören ; Song, Jian ; ieee-holm (Hrsg.): Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts, Electrical contacts. Piscataway, NJ : IEEE, 2025' havard: M. Blauth, S. Tülling, J. Song, Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts, IEEE, Piscataway, NJ, 2025. ieee: 'M. Blauth, S. Tülling, and J. Song, Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts. Piscataway, NJ: IEEE, 2025. doi: 10.1109/hlm51652.2025.11278329.' mla: Blauth, Michael, et al. “Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts.” Proceedings of the 70th IEEE Holm Conference on Electrical Contacts (HLM), edited by ieee-holm, IEEE, 2025, https://doi.org/10.1109/hlm51652.2025.11278329. short: M. Blauth, S. Tülling, J. Song, Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts, IEEE, Piscataway, NJ, 2025. ufg: 'Blauth, Michael/Tülling, Sören/Song, Jian: Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts, hg. von ieee-holm, Piscataway, NJ 2025 (Electrical contacts).' van: 'Blauth M, Tülling S, Song J. Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts. ieee-holm, editor. Proceedings of the 70th IEEE Holm Conference on Electrical Contacts (HLM). Piscataway, NJ: IEEE; 2025. (Electrical contacts).' conference: end_date: 2025-10-22 location: 'San Antonio, TX, USA ' name: 70th Holm Conference on Electrical Contacts (HLM) start_date: 2025-10-15 corporate_editor: - ieee-holm date_created: 2026-02-24T14:48:06Z date_updated: 2026-02-27T11:06:57Z department: - _id: DEP6000 - _id: DEP6012 doi: 10.1109/hlm51652.2025.11278329 keyword: - Connectors - Resistance - Silver - Lubricants - Contacts - Oils - Friction - Corrosion - Optimization language: - iso: eng place: Piscataway, NJ publication: Proceedings of the 70th IEEE Holm Conference on Electrical Contacts (HLM) publication_identifier: eisbn: - 979-8-3315-5996-0 isbn: - 979-8-3315-5997-7 issn: - 2158-9992 publication_status: published publisher: IEEE series_title: Electrical contacts status: public title: Effect of Operating Temperature and Application Quantity of Lubricants on the Fretting Behavior of Silver Plated Electrical Contacts type: conference_editor_article user_id: '83778' year: '2025' ... --- _id: '10985' abstract: - lang: eng text: This thesis examines the impacts of scene and rendering optimizations techniques aimed for GPU rendering within the realm of animated scene for offline rendering. Focusing on the unique challenges posed by dynamic animations, the research explores how these rendering approaches impact rendering speed, memory efficiency, and the attainment of lifelike visual quality. Using Octane render as ground for analysis, this study aims to uncover how scene optimizations intersect with the demands of animated content. Through meticulous comparison, this thesis endeavours to provide insights that empower rendering practitioners and animators to go through optimization strategies, bridging the gap between efficient resource allocation and the pursuit of captivating visual. author: - first_name: Lucas full_name: De Melo Bernardino, Lucas id: '72490' last_name: De Melo Bernardino citation: ama: 'De Melo Bernardino L. Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study Using Octane for Cinema 4D. Technischen Hochschule Ostwestfahlen-Lippe; 2024.' apa: 'De Melo Bernardino, L. (2024). Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study using Octane for Cinema 4D. Technischen Hochschule Ostwestfahlen-Lippe.' bjps: 'De Melo Bernardino L (2024) Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study Using Octane for Cinema 4D. Detmold: Technischen Hochschule Ostwestfahlen-Lippe.' chicago: 'De Melo Bernardino, Lucas. Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study Using Octane for Cinema 4D. Detmold: Technischen Hochschule Ostwestfahlen-Lippe, 2024.' chicago-de: 'De Melo Bernardino, Lucas. 2024. Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study using Octane for Cinema 4D. Detmold: Technischen Hochschule Ostwestfahlen-Lippe.' din1505-2-1: 'De Melo Bernardino, Lucas: Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study using Octane for Cinema 4D. Detmold : Technischen Hochschule Ostwestfahlen-Lippe, 2024' havard: 'L. De Melo Bernardino, Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study using Octane for Cinema 4D, Technischen Hochschule Ostwestfahlen-Lippe, Detmold, 2024.' ieee: 'L. De Melo Bernardino, Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study using Octane for Cinema 4D. Detmold: Technischen Hochschule Ostwestfahlen-Lippe, 2024.' mla: 'De Melo Bernardino, Lucas. Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study Using Octane for Cinema 4D. Technischen Hochschule Ostwestfahlen-Lippe, 2024.' short: 'L. De Melo Bernardino, Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study Using Octane for Cinema 4D, Technischen Hochschule Ostwestfahlen-Lippe, Detmold, 2024.' ufg: 'De Melo Bernardino, Lucas: Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study using Octane for Cinema 4D, Detmold 2024.' van: 'De Melo Bernardino L. Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study using Octane for Cinema 4D. Detmold: Technischen Hochschule Ostwestfahlen-Lippe; 2024. 55 p.' date_created: 2024-02-01T07:25:50Z date_updated: 2024-02-01T12:56:04Z ddc: - '770' defense_date: 2024-01-29 department: - _id: DEP2001 file: - access_level: open_access content_type: application/pdf creator: adm-hemke date_created: 2024-02-01T12:50:55Z date_updated: 2024-02-01T12:50:55Z file_id: '10990' file_name: EnhancingGPU_RenderingEfficiencyThroughSceneOptimizations.pdf file_size: 54572345 relation: main_file success: 1 file_date_updated: 2024-02-01T12:50:55Z has_accepted_license: '1' keyword: - GPU Rendering - Scene Optimization - 3D Rendering - Cinema 4D - Octane Render language: - iso: eng oa: '1' page: '55' place: Detmold publication_status: published publisher: Technischen Hochschule Ostwestfahlen-Lippe status: public supervisor: - first_name: Rico full_name: Dober, Rico id: '76705' last_name: Dober - first_name: Jennifer full_name: Meier, Jennifer id: '85353' last_name: Meier title: 'Enhancing GPU Rendering Efficiency through Scene Optimizations: A Case Study using Octane for Cinema 4D' type: bachelor_thesis user_id: '83781' year: '2024' ... --- _id: '12009' abstract: - lang: eng text: 'AbstractTraditional work models often need more flexibility and time autonomy for employees, especially in manufacturing. Quantitative approaches and Artificial Intelligence (AI) applications offer the potential to improve work design. However, current research does not entirely focus on human-centric criteria that enable time autonomy. This paper addresses this gap by developing a set of criteria to evaluate intelligent personnel planning approaches based on their ability to enhance time autonomy for employees. Existing quantitative approaches are not sufficient to fully integrate the developed criteria.Consequently, a novel model approach is proposed in an attempt to bridge the gap between current practices and the newly developed criteria. This two-stage planning approach fosters democratization of time autonomy on the shopfloor, moving beyond traditional top-down scheduling. The paper concludes by outlining the implementation process and discusses future developments with respect to AI for this model approach.Practical Relevance: In order to make working conditions on the shopfloor in high-wage countries more attractive, an alternative organization of shift work is needed. Intelligent planning approaches that combine traditional operations research methods with artificial intelligence approaches can democratize shift organization regarding time autonomy. Planning that takes both employee and employer preferences into account in a balanced way will strengthen the long-term competitiveness of manufacturing companies in high-wage countries and counteract the shortage of skilled labor.' author: - first_name: Benedikt full_name: Latos, Benedikt id: '84474' last_name: Latos - first_name: Armin full_name: Buckhorst, Armin last_name: Buckhorst - first_name: Peyman full_name: Kalantar, Peyman id: '85984' last_name: Kalantar - first_name: Dominik full_name: Bentler, Dominik last_name: Bentler - first_name: Stefan full_name: Gabriel, Stefan last_name: Gabriel - first_name: Roman full_name: Dumitrescu, Roman last_name: Dumitrescu - first_name: Michael full_name: Minge, Michael id: '78302' last_name: Minge orcid: 0000-0003-1930-7064 - first_name: Barbara full_name: Steinmann, Barbara id: '77747' last_name: Steinmann orcid: 0009-0000-3036-2684 - first_name: Nadine full_name: Guhr, Nadine id: '77748' last_name: Guhr orcid: 0000-0001-8812-1488 citation: ama: 'Latos B, Buckhorst A, Kalantar P, et al. Time autonomy in personnel planning: Requirements and solution approaches in the context of intelligent scheduling from a holistic organizational perspective . Zeitschrift für Arbeitswissenschaft. 2024;78(3):277-298. doi:10.1007/s41449-024-00432-7' apa: 'Latos, B., Buckhorst, A., Kalantar, P., Bentler, D., Gabriel, S., Dumitrescu, R., Minge, M., Steinmann, B., & Guhr, N. (2024). Time autonomy in personnel planning: Requirements and solution approaches in the context of intelligent scheduling from a holistic organizational perspective . Zeitschrift Für Arbeitswissenschaft, 78(3), 277–298. https://doi.org/10.1007/s41449-024-00432-7' bjps: 'Latos B et al. (2024) Time Autonomy in Personnel Planning: Requirements and Solution Approaches in the Context of Intelligent Scheduling from a Holistic Organizational Perspective . Zeitschrift für Arbeitswissenschaft 78, 277–298.' chicago: 'Latos, Benedikt, Armin Buckhorst, Peyman Kalantar, Dominik Bentler, Stefan Gabriel, Roman Dumitrescu, Michael Minge, Barbara Steinmann, and Nadine Guhr. “Time Autonomy in Personnel Planning: Requirements and Solution Approaches in the Context of Intelligent Scheduling from a Holistic Organizational Perspective .” Zeitschrift Für Arbeitswissenschaft 78, no. 3 (2024): 277–98. https://doi.org/10.1007/s41449-024-00432-7.' chicago-de: 'Latos, Benedikt, Armin Buckhorst, Peyman Kalantar, Dominik Bentler, Stefan Gabriel, Roman Dumitrescu, Michael Minge, Barbara Steinmann und Nadine Guhr. 2024. Time autonomy in personnel planning: Requirements and solution approaches in the context of intelligent scheduling from a holistic organizational perspective . Zeitschrift für Arbeitswissenschaft 78, Nr. 3: 277–298. doi:10.1007/s41449-024-00432-7, .' din1505-2-1: 'Latos, Benedikt ; Buckhorst, Armin ; Kalantar, Peyman ; Bentler, Dominik ; Gabriel, Stefan ; Dumitrescu, Roman ; Minge, Michael ; Steinmann, Barbara ; u. a.: Time autonomy in personnel planning: Requirements and solution approaches in the context of intelligent scheduling from a holistic organizational perspective . In: Zeitschrift für Arbeitswissenschaft Bd. 78. Heidelberg, Springer-Verlag GmbH (2024), Nr. 3, S. 277–298' havard: 'B. Latos, A. Buckhorst, P. Kalantar, D. Bentler, S. Gabriel, R. Dumitrescu, M. Minge, B. Steinmann, N. Guhr, Time autonomy in personnel planning: Requirements and solution approaches in the context of intelligent scheduling from a holistic organizational perspective , Zeitschrift Für Arbeitswissenschaft. 78 (2024) 277–298.' ieee: 'B. Latos et al., “Time autonomy in personnel planning: Requirements and solution approaches in the context of intelligent scheduling from a holistic organizational perspective ,” Zeitschrift für Arbeitswissenschaft, vol. 78, no. 3, pp. 277–298, 2024, doi: 10.1007/s41449-024-00432-7.' mla: 'Latos, Benedikt, et al. “Time Autonomy in Personnel Planning: Requirements and Solution Approaches in the Context of Intelligent Scheduling from a Holistic Organizational Perspective .” Zeitschrift Für Arbeitswissenschaft, vol. 78, no. 3, 2024, pp. 277–98, https://doi.org/10.1007/s41449-024-00432-7.' short: B. Latos, A. Buckhorst, P. Kalantar, D. Bentler, S. Gabriel, R. Dumitrescu, M. Minge, B. Steinmann, N. Guhr, Zeitschrift Für Arbeitswissenschaft 78 (2024) 277–298. ufg: 'Latos, Benedikt u. a.: Time autonomy in personnel planning: Requirements and solution approaches in the context of intelligent scheduling from a holistic organizational perspective , in: Zeitschrift für Arbeitswissenschaft 78 (2024), H. 3,  S. 277–298.' van: 'Latos B, Buckhorst A, Kalantar P, Bentler D, Gabriel S, Dumitrescu R, et al. Time autonomy in personnel planning: Requirements and solution approaches in the context of intelligent scheduling from a holistic organizational perspective . Zeitschrift für Arbeitswissenschaft. 2024;78(3):277–98.' date_created: 2024-10-28T09:08:47Z date_updated: 2024-10-28T15:09:13Z department: - _id: DEP1523 doi: 10.1007/s41449-024-00432-7 intvolume: ' 78' issue: '3' keyword: - Personnel Planning - Time Autonomy - Human-Centric Optimization - Artificial Intelligence - Manufacturing language: - iso: eng page: 277-298 place: Heidelberg publication: Zeitschrift für Arbeitswissenschaft publication_identifier: eissn: - 2366-4681 issn: - 0340-2444 publication_status: published publisher: Springer-Verlag GmbH quality_controlled: '1' status: public title: 'Time autonomy in personnel planning: Requirements and solution approaches in the context of intelligent scheduling from a holistic organizational perspective ' type: scientific_journal_article user_id: '83781' volume: 78 year: '2024' ... --- _id: '13335' abstract: - lang: eng text: "The process of thermal preservation of liquid foods is a safety-relevant process step in the processing of products such as fruit juices and is associated with a high-energy expenditure and safety margin. There are already various approaches to improve this conventionally managed process step in terms of product and resource preservation. Compared to these novel technologies, the use of real-time process analytics offers great potential to improve already existing process plants by implementing inline capable process analytical tools. This allows direct control of the reactions taking place and changes during the running process. Instead of post process, random product control, quality control during the process can be made rendered. The chemical and pharmaceutical industry serves as a reference industry for the use of process analytical tools, although the reactions and product matrices are less complex. In the food industry, on the other hand, there is a greater variation in raw materials and intermediate products. In addition, a large number of reactions can take place in parallel within a process, and the physical states and properties of the individual components can vary. A uniform set of rules for the use of process analytical tools does not exist here. Each product, each process provides its own research potential, so that a large research gap opens up in the area of the food industry.\r\nIn order to contribute to closing this gap, this thesis presents a novel approach to improve the process of pasteurization of liquid food. For fruit juices as an application, near infrared spectroscopy in combination with chemometric methods was applied to make the process more product specific. Based on known weaknesses of the process, the relevant aspects for a product-specific treatment were identified. In the further course, the suitability of near infrared spectroscopy as a process analytical tool in the process of pasteurization was verified. Moreover, it was investigated whether a sufficiently accurate identification of the product type as well as the microbiologically relevant properties can be achieved by the application of chemometric methods. In the course of this, the suitability of the measurement methodology was confirmed and solutions were established for any process influences. The product classification and description of the microbiologically relevant parameters extract content and pH value were also implemented with sufficient accuracy. Knowing the destruction kinetics of relevant microorganisms, the product-specific determination of target values for the necessary lethal heat input could be realized. In addition, an analysis of the actual values was carried out on the basis of a chemometric regression method by inferring the microbiological pasteurization effect through the chemical reaction of acid hydrolytic sucrose degradation by means of the indirect approach. This required knowledge of the chemical reaction kinetics and mahematical modeling of the degradation behavior. The novel approach could be confirmed by calculations using results from off-line analysis, whereas the use of near infrared spectroscopy as an inline method still revealed potential for optimization with respect to measurement accuracies.\r\nIn summary, the results of this work provide a promising opportunity to make conventional processes for the preservation of liquid foods more product-specific by using near-infrared spectroscopy as an inline-capable and multimodal sensor technique, leading to an increase in process efficiency and product quality." - lang: ger text: "Der Prozess der thermischen Haltbarmachung von flüssigen Lebensmitteln ist ein sicherheitsrelevanter Prozessschritt in der Verarbeitung von Produkten wie Fruchtsäften und ist mit einem hohen energetischen Aufwand und Sicherheitszuschlag verbunden. Um diesen konventionell geführten Prozessschritt hinsichtlich Produkt- und Ressourcenschonung zu optimieren, gibt es bereits verschiedene Ansätze. Im Vergleich zu neuartigen Technologien bietet der Einsatz von Echtzeit-Prozessanalytik großes Potential bereits bestehende Prozessanlagen durch die Implementierung inlinefähiger Prozessanalysetools zu verbessern. Dies ermöglicht eine Kontrolle ablaufender Reaktionen im laufenden Prozess. Anstelle nachgelagerter, stichprobenartiger Produktkontrolle kann eine Qualitätslenkung im Prozess erfolgen. Vorbildindustrie bezüglich des Einsatzes von Prozessanalysetools ist die pharmazeutische Industrie, wo Reaktionen und Produktmatrices allerdings weniger komplex sind. In der Lebensmittelindustrie gibt es eine größere Schwankungsbreite der Rohstoffe und Zwischenprodukte. Zudem können innerhalb eines Prozesses eine Vielzahl an Reaktionen parallel ablaufen und die Zustandsformen und Eigenschaften der einzelnen Komponenten variieren. Ein einheitliches Regelwerk zum Einsatz der Prozessanalysetools existiert nicht. Jedes Produkt, jeder Prozess liefert eigenes Forschungspotential, sodass sich im Bereich der Lebensmittelindustrie eine große Forschungslücke auftut.\r\nUm einen Beitrag zur Schließung dieser Lücke zu leisten, zeigt diese Arbeit einen neuartigen Lösungsansatz auf, um den Prozess der Pasteurisation flüssiger Lebensmittel zu verbessern. Am Anwendungsfall von Fruchtsäften wurde der Einsatz von Nahinfrarotspektroskopie in Kombination mit chemometrischen Methoden genutzt, um den Prozess produktspezifischer zu gestalten. Ausgehend von bekannten Schwachstellen des Prozesses wurden die relevanten Aspekte identifiziert, deren Kenntnis für eine produktspezifische Behandlung relevant sind. Angefangen mit der Überprüfung der Eignung von Nahinfrarotspektroskopie als Prozessanalysetool im Prozess der Pasteurisation, wurde untersucht, ob eine Identifikation des Produkttyps sowie der mikrobiologisch relevanten Eigenschaften durch die Anwendung chemometrischer Methoden erfolgen kann. In diesem Zuge konnte eine Eignung der Messmethodik bestätigt werden und für etwaige Prozesseinflüsse Lösungsansätze etabliert werden. Auch die Produktklassifizierung und Beschreibung der mikrobiologisch relevanten Parameter Extraktgehalt und pH-Wert wurden hinreichend genau umgesetzt. Unter Kenntnis der Abtötungskinetiken entsprechend relevanter Mikroorganismen konnte die produktspezifische Ermittlung für Sollwerte des notwendigen letalen Hitzeeintrags realisiert werden. Im Weiteren wurde eine Analyse der Ist-Werte auf Basis einer chemometrischen Regressionsmethode durchgeführt, indem mittels des indirekten Ansatzes über die chemische Reaktion der säurehydrolytischen Saccharosedegradation auf den mikrobiologischen Pasteurisationseffekt geschlossen wurde. Dazu war die Kenntnis der chemischen Reaktionskinetik notwendig und die mathematische Modellierung des Abbauverhaltens. Der neuartige Ansatz konnte mittels Berechnungen unter Verwendung von Ergebnissen der Offline-Analytik bestätigt werden. Der Einsatz von Nahinfrarotspektroskopie als Inline- Methode hingegen offenbarte Optimierungspotenzial hinsichtlich der Messgenauigkeiten.\r\nZusammenfassend liefern die Ergebnisse dieser Arbeit eine vielversprechende Möglichkeit herkömmliche Prozesse zur Haltbarmachung von flüssigen Lebensmitteln durch den Einsatz von Nahinfrarotspektroskopie als inlinefähige, multimodale Sensortechnik produktspezifischer zu gestalten, was zur Steigerung der Prozesseffizienz und Produktqualität führt." author: - first_name: Imke full_name: Weishaupt, Imke id: '58425' last_name: Weishaupt citation: ama: Weishaupt I. Near Infrared Spectroscopy as Inline Analytical Tool to Optimize the Pasteurization Process of Liquid Foods. Technische Universität Berlin; 2023. doi:https://doi.org/10.14279/depositonce-17804 apa: Weishaupt, I. (2023). Near infrared spectroscopy as inline analytical tool to optimize the pasteurization process of liquid foods. Technische Universität Berlin. https://doi.org/10.14279/depositonce-17804 bjps: 'Weishaupt I (2023) Near Infrared Spectroscopy as Inline Analytical Tool to Optimize the Pasteurization Process of Liquid Foods. Berlin: Technische Universität Berlin.' chicago: 'Weishaupt, Imke. Near Infrared Spectroscopy as Inline Analytical Tool to Optimize the Pasteurization Process of Liquid Foods. Berlin: Technische Universität Berlin, 2023. https://doi.org/10.14279/depositonce-17804.' chicago-de: 'Weishaupt, Imke. 2023. Near infrared spectroscopy as inline analytical tool to optimize the pasteurization process of liquid foods. Berlin: Technische Universität Berlin. doi:https://doi.org/10.14279/depositonce-17804, .' din1505-2-1: 'Weishaupt, Imke: Near infrared spectroscopy as inline analytical tool to optimize the pasteurization process of liquid foods. Berlin : Technische Universität Berlin, 2023' havard: I. Weishaupt, Near infrared spectroscopy as inline analytical tool to optimize the pasteurization process of liquid foods, Technische Universität Berlin, Berlin, 2023. ieee: 'I. Weishaupt, Near infrared spectroscopy as inline analytical tool to optimize the pasteurization process of liquid foods. Berlin: Technische Universität Berlin, 2023. doi: https://doi.org/10.14279/depositonce-17804.' mla: Weishaupt, Imke. Near Infrared Spectroscopy as Inline Analytical Tool to Optimize the Pasteurization Process of Liquid Foods. Technische Universität Berlin, 2023, https://doi.org/10.14279/depositonce-17804. short: I. Weishaupt, Near Infrared Spectroscopy as Inline Analytical Tool to Optimize the Pasteurization Process of Liquid Foods, Technische Universität Berlin, Berlin, 2023. ufg: 'Weishaupt, Imke: Near infrared spectroscopy as inline analytical tool to optimize the pasteurization process of liquid foods, Berlin 2023.' van: 'Weishaupt I. Near infrared spectroscopy as inline analytical tool to optimize the pasteurization process of liquid foods. Berlin: Technische Universität Berlin; 2023. 144 p.' date_created: 2026-01-09T11:56:40Z date_updated: 2026-01-12T08:47:34Z defense_date: 2023-05-05 department: - _id: DEP4028 doi: https://doi.org/10.14279/depositonce-17804 keyword: - fruit juice pasteurization - near infrared spectroscopy - process optimization - multivariate statistics - inline process analytics - Fruchtsaftpasteurisation - Prozessoptimierung - Nahinfrarotspektroskopie - multivariate Statistik - Inline-Prozessanalytik language: - iso: eng page: '144' place: Berlin publication_status: published publisher: Technische Universität Berlin status: public supervisor: - first_name: 'Juri ' full_name: 'Rappsilber, Juri ' last_name: Rappsilber - first_name: 'Peter ' full_name: 'Neubauer, Peter ' last_name: Neubauer - first_name: Jan full_name: Schneider, Jan id: '13209' last_name: Schneider orcid: 0000-0001-6401-8873 - first_name: 'Leif-Alexander ' full_name: 'Garbe, Leif-Alexander ' last_name: Garbe title: Near infrared spectroscopy as inline analytical tool to optimize the pasteurization process of liquid foods type: dissertation user_id: '83781' year: '2023' ... --- _id: '10787' abstract: - lang: eng text: Cyber-physical production systems have emerged with the rise of Industry 4.0 in different industrial fields. Especially the food sector, where inhomogeneous input products like beer/yeast suspensions with different qualities and properties have yet slowed down automation, has potential for this evolution. This contribution presents optimization methods for a dynamical cross-flow filtration plant which is driven by an advanced control concept in combination with data driven product monitoring via inline near infrared spectroscopy (NIR) in order to improve energy savings and filtration performance. Using a hierarchical control and optimization structure, the non stationary batch process is steered towards a high production rate with low energy consumption for a variety of different input products. author: - first_name: Jörn full_name: Tebbe, Jörn id: '79072' last_name: Tebbe - first_name: Thomas full_name: Pawlik, Thomas id: '58915' last_name: Pawlik - first_name: Marc full_name: Trilling-Haasler, Marc id: '81622' last_name: Trilling-Haasler orcid: 0000-0002-3685-6383 - first_name: Jannis full_name: Löbner, Jannis id: '74097' last_name: Löbner - first_name: Markus full_name: Lange-Hegermann, Markus id: '71761' last_name: Lange-Hegermann - first_name: Jan full_name: Schneider, Jan id: '13209' last_name: Schneider orcid: 0000-0001-6401-8873 citation: ama: Tebbe J, Pawlik T, Trilling-Haasler M, Löbner J, Lange-Hegermann M, Schneider J. Holistic Optimization of a Dynamic Cross-Flow Filtration Process towards a Cyber-Physical System. (Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , eds.). IEEE; 2023:1-7. doi:10.1109/INDIN51400.2023.10217913 apa: Tebbe, J., Pawlik, T., Trilling-Haasler, M., Löbner, J., Lange-Hegermann, M., & Schneider, J. (2023). Holistic optimization of a dynamic cross-flow filtration process towards a cyber-physical system. In J. Jasperneite, L. Wisniewski, K. Fung Man, & Institute of Electrical and Electronics Engineers (Eds.), 2023 IEEE 21st International Conference on Industrial Informatics (INDIN) (pp. 1–7). IEEE. https://doi.org/10.1109/INDIN51400.2023.10217913 bjps: 'Tebbe J et al. (2023) Holistic Optimization of a Dynamic Cross-Flow Filtration Process towards a Cyber-Physical System, Jasperneite J et al. (eds). [Piscataway, NJ]: IEEE.' chicago: 'Tebbe, Jörn, Thomas Pawlik, Marc Trilling-Haasler, Jannis Löbner, Markus Lange-Hegermann, and Jan Schneider. Holistic Optimization of a Dynamic Cross-Flow Filtration Process towards a Cyber-Physical System. Edited by Jürgen Jasperneite, Lukasz Wisniewski, Kim Fung Man, and Institute of Electrical and Electronics Engineers . 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE, 2023. https://doi.org/10.1109/INDIN51400.2023.10217913.' chicago-de: 'Tebbe, Jörn, Thomas Pawlik, Marc Trilling-Haasler, Jannis Löbner, Markus Lange-Hegermann und Jan Schneider. 2023. Holistic optimization of a dynamic cross-flow filtration process towards a cyber-physical system. Hg. von Jürgen Jasperneite, Lukasz Wisniewski, Kim Fung Man, und Institute of Electrical and Electronics Engineers . 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE. doi:10.1109/INDIN51400.2023.10217913, .' din1505-2-1: 'Tebbe, Jörn ; Pawlik, Thomas ; Trilling-Haasler, Marc ; Löbner, Jannis ; Lange-Hegermann, Markus ; Schneider, Jan ; Jasperneite, J. ; Wisniewski, L. ; Fung Man, K. ; Institute of Electrical and Electronics Engineers (Hrsg.): Holistic optimization of a dynamic cross-flow filtration process towards a cyber-physical system. [Piscataway, NJ] : IEEE, 2023' havard: J. Tebbe, T. Pawlik, M. Trilling-Haasler, J. Löbner, M. Lange-Hegermann, J. Schneider, Holistic optimization of a dynamic cross-flow filtration process towards a cyber-physical system, IEEE, [Piscataway, NJ], 2023. ieee: 'J. Tebbe, T. Pawlik, M. Trilling-Haasler, J. Löbner, M. Lange-Hegermann, and J. Schneider, Holistic optimization of a dynamic cross-flow filtration process towards a cyber-physical system. [Piscataway, NJ]: IEEE, 2023, pp. 1–7. doi: 10.1109/INDIN51400.2023.10217913.' mla: Tebbe, Jörn, et al. “Holistic Optimization of a Dynamic Cross-Flow Filtration Process towards a Cyber-Physical System.” 2023 IEEE 21st International Conference on Industrial Informatics (INDIN), edited by Jürgen Jasperneite et al., IEEE, 2023, pp. 1–7, https://doi.org/10.1109/INDIN51400.2023.10217913. short: J. Tebbe, T. Pawlik, M. Trilling-Haasler, J. Löbner, M. Lange-Hegermann, J. Schneider, Holistic Optimization of a Dynamic Cross-Flow Filtration Process towards a Cyber-Physical System, IEEE, [Piscataway, NJ], 2023. ufg: 'Tebbe, Jörn u. a.: Holistic optimization of a dynamic cross-flow filtration process towards a cyber-physical system, hg. von Jasperneite, Jürgen u. a., [Piscataway, NJ] 2023.' van: 'Tebbe J, Pawlik T, Trilling-Haasler M, Löbner J, Lange-Hegermann M, Schneider J. Holistic optimization of a dynamic cross-flow filtration process towards a cyber-physical system. Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , editors. 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE; 2023.' conference: end_date: 2023-07-20 location: Lemgo name: 21st International Conference on Industrial Informatics ; INDIN 2023 start_date: 2023-07-17 corporate_editor: - 'Institute of Electrical and Electronics Engineers ' date_created: 2023-11-21T08:04:41Z date_updated: 2025-06-26T07:48:22Z department: - _id: DEP4018 - _id: DEP1308 - _id: DEP4028 doi: 10.1109/INDIN51400.2023.10217913 editor: - first_name: Jürgen full_name: Jasperneite, Jürgen id: '1899' last_name: Jasperneite - first_name: Lukasz full_name: Wisniewski, Lukasz id: '1710' last_name: Wisniewski - first_name: Kim full_name: Fung Man, Kim last_name: Fung Man keyword: - Spectroscopy - Production systems - Filtration - Velocity control - Optimization methods - Cyber-physical systems - Nonhomogeneous media language: - iso: eng page: 1-7 place: '[Piscataway, NJ]' publication: 2023 IEEE 21st International Conference on Industrial Informatics (INDIN) publication_identifier: eisbn: - 978-1-6654-9313-0 isbn: - '978-1-6654-9314-7 ' issn: - 1935-4576 publication_status: published publisher: IEEE status: public title: Holistic optimization of a dynamic cross-flow filtration process towards a cyber-physical system type: conference_editor_article user_id: '83781' year: '2023' ... --- _id: '11428' abstract: - lang: eng text: Systems that place high demands on availability are typically modular in design. However, a modular design also offers potential for optimized operation under norma requirements. In this paper we present an approach to find optimal operating points from the characteristic fields of individual modules. Our approach consists of a two-step procedure. In the first stage, Pareto sets are calculated using the NSGA-II genetic algorithm. The second stage contains a heuristic that finds situationally optimal operating points using a defined operating strategy. author: - first_name: Maximilian full_name: Lammersen, Maximilian id: '81623' last_name: Lammersen orcid: 0009-0001-9092-9088 - first_name: Rainer full_name: Rasche, Rainer id: '74574' last_name: Rasche citation: ama: Lammersen M, Rasche R. Optimized Operating Points for Power Electronic Building Blocks. * apa: Lammersen, M., & Rasche, R. (n.d.). Optimized Operating Points for Power Electronic Building Blocks. In Conference proceedings of Mecatronics & AISM 2023. Mecatronics & AISM2023, Yokohama. *. bjps: Lammersen M and Rasche R (n.d.) Optimized Operating Points for Power Electronic Building Blocks. *. chicago: Lammersen, Maximilian, and Rainer Rasche. Optimized Operating Points for Power Electronic Building Blocks. Conference Proceedings of Mecatronics & AISM 2023. *, n.d. chicago-de: Lammersen, Maximilian und Rainer Rasche. Optimized Operating Points for Power Electronic Building Blocks. Conference proceedings of Mecatronics & AISM 2023. *. din1505-2-1: 'Lammersen, Maximilian ; Rasche, Rainer: Optimized Operating Points for Power Electronic Building Blocks : *' havard: M. Lammersen, R. Rasche, Optimized Operating Points for Power Electronic Building Blocks, *, n.d. ieee: M. Lammersen and R. Rasche, Optimized Operating Points for Power Electronic Building Blocks. *. mla: Lammersen, Maximilian, and Rainer Rasche. “Optimized Operating Points for Power Electronic Building Blocks.” Conference Proceedings of Mecatronics & AISM 2023, *. short: M. Lammersen, R. Rasche, Optimized Operating Points for Power Electronic Building Blocks, *, n.d. ufg: 'Lammersen, Maximilian/Rasche, Rainer: Optimized Operating Points for Power Electronic Building Blocks, o. O. u. J. .' van: Lammersen M, Rasche R. Optimized Operating Points for Power Electronic Building Blocks. Conference proceedings of Mecatronics & AISM 2023. *; conference: end_date: 2023-09-11 location: Yokohama name: Mecatronics & AISM2023 start_date: 2023-09-09 date_created: 2024-05-02T09:25:01Z date_updated: 2024-05-15T07:21:59Z department: - _id: DEP5026 - _id: DEP6020 keyword: - modularity - optimization - PEBB - operating strategy - genetic algorithm - Pareto language: - iso: eng publication: Conference proceedings of Mecatronics & AISM 2023 publication_status: accepted publisher: '*' quality_controlled: '1' status: public title: Optimized Operating Points for Power Electronic Building Blocks type: conference_editor_article user_id: '83781' year: '2023' ... --- _id: '12806' abstract: - lang: eng text: Cyber-Physical Systems (CPS) play an essential role in today’s production processes, leveraging Artificial Intelligence (AI) to enhance operations such as optimization, anomaly detection, and predictive maintenance. This article reviews a cognitive architecture for Artificial Intelligence, which has been developed to establish a standard framework for integrating AI solutions into existing production processes. Given that machines in these processes continuously generate large streams of data, Online Machine Learning (OML) is identified as a crucial extension to the existing architecture. To substantiate this claim, real-world experiments using a slitting machine are conducted, to compare the performance of OML to traditional Batch Machine Learning. The assessment of contemporary OML algorithms using a real production system is a fundamental innovation in this research. The evaluations clearly indicate that OML adds significant value to CPS, and it is strongly recommended as an extension of related architectures, such as the cognitive architecture for AI discussed in this article. Additionally, surrogate-model-based optimization is employed, to determine the optimal hyperparameter settings for the corresponding OML algorithms, aiming to achieve peak performance in their respective tasks. article_number: '11506' author: - first_name: Alexander full_name: Hinterleitner, Alexander last_name: Hinterleitner - first_name: Richard full_name: Schulz, Richard last_name: Schulz - first_name: Lukas full_name: Hans, Lukas last_name: Hans - first_name: Aleksandr full_name: Subbotin, Aleksandr last_name: Subbotin - first_name: Nils full_name: Barthel, Nils last_name: Barthel - first_name: Noah full_name: Pütz, Noah last_name: Pütz - first_name: Martin full_name: Rosellen, Martin last_name: Rosellen - first_name: Thomas full_name: Bartz-Beielstein, Thomas last_name: Bartz-Beielstein - first_name: Christoph full_name: Geng, Christoph id: '61408' last_name: Geng - first_name: Phillip full_name: Priss, Phillip last_name: Priss citation: ama: 'Hinterleitner A, Schulz R, Hans L, et al. Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture.   Applied Sciences : open access journal. 2023;13(20). doi:10.3390/app132011506' apa: 'Hinterleitner, A., Schulz, R., Hans, L., Subbotin, A., Barthel, N., Pütz, N., Rosellen, M., Bartz-Beielstein, T., Geng, C., & Priss, P. (2023). Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture.   Applied Sciences : Open Access Journal, 13(20), Article 11506. https://doi.org/10.3390/app132011506' bjps: 'Hinterleitner A et al. (2023) Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture.   Applied Sciences : open access journal 13.' chicago: 'Hinterleitner, Alexander, Richard Schulz, Lukas Hans, Aleksandr Subbotin, Nils Barthel, Noah Pütz, Martin Rosellen, Thomas Bartz-Beielstein, Christoph Geng, and Phillip Priss. “Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture.”   Applied Sciences : Open Access Journal 13, no. 20 (2023). https://doi.org/10.3390/app132011506.' chicago-de: 'Hinterleitner, Alexander, Richard Schulz, Lukas Hans, Aleksandr Subbotin, Nils Barthel, Noah Pütz, Martin Rosellen, Thomas Bartz-Beielstein, Christoph Geng und Phillip Priss. 2023. Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture.   Applied Sciences : open access journal 13, Nr. 20. doi:10.3390/app132011506, .' din1505-2-1: 'Hinterleitner, Alexander ; Schulz, Richard ; Hans, Lukas ; Subbotin, Aleksandr ; Barthel, Nils ; Pütz, Noah ; Rosellen, Martin ; Bartz-Beielstein, Thomas ; u. a.: Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture. In:   Applied Sciences : open access journal Bd. 13. Basel, MDPI AG (2023), Nr. 20' havard: 'A. Hinterleitner, R. Schulz, L. Hans, A. Subbotin, N. Barthel, N. Pütz, M. Rosellen, T. Bartz-Beielstein, C. Geng, P. Priss, Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture,   Applied Sciences : Open Access Journal. 13 (2023).' ieee: 'A. Hinterleitner et al., “Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture,”   Applied Sciences : open access journal, vol. 13, no. 20, Art. no. 11506, 2023, doi: 10.3390/app132011506.' mla: 'Hinterleitner, Alexander, et al. “Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture.”   Applied Sciences : Open Access Journal, vol. 13, no. 20, 11506, 2023, https://doi.org/10.3390/app132011506.' short: 'A. Hinterleitner, R. Schulz, L. Hans, A. Subbotin, N. Barthel, N. Pütz, M. Rosellen, T. Bartz-Beielstein, C. Geng, P. Priss,   Applied Sciences : Open Access Journal 13 (2023).' ufg: 'Hinterleitner, Alexander u. a.: Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture, in:   Applied Sciences : open access journal 13 (2023), H. 20.' van: 'Hinterleitner A, Schulz R, Hans L, Subbotin A, Barthel N, Pütz N, et al. Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture.   Applied Sciences : open access journal. 2023;13(20).' date_created: 2025-04-16T07:27:52Z date_updated: 2025-06-26T07:50:56Z department: - _id: DEP5023 doi: 10.3390/app132011506 external_id: isi: - '001096019200001' intvolume: ' 13' isi: '1' issue: '20' keyword: - machine learning - online algorithms - cyber-physical production systems - surrogate-based optimization language: - iso: eng place: Basel publication: ' Applied Sciences : open access journal' publication_identifier: issn: - 2076-3417 publication_status: published publisher: MDPI AG status: public title: Online Machine Learning and Surrogate-Model-Based Optimization for Improved Production Processes Using a Cognitive Architecture type: scientific_journal_article user_id: '83781' volume: 13 year: '2023' ... --- _id: '11377' abstract: - lang: eng text: consuming and often performed rather empirically. Efficient optimization of multiple objectives such as process time, viable cell density, number of operating steps & cultivation scales, required medium, amount of product as well as product quality depicts a promising approach. This contribution presents a workflow which couples uncertainty-based upstream simulation and Bayes optimization using Gaussian processes. Its application is demonstrated in a simulation case study for a relevant industrial task in process development, the design of a robust cell culture expansion process (seed train), meaning that despite uncertainties and variabilities concerning cell growth, low variations of viable cell density during the seed train are obtained. Compared to a non-optimized reference seed train, the optimized process showed much lower deviation rates regarding viable cell densities (<10% instead of 41.7%) using five or four shake flask scales and seed train duration could be reduced by 56 h from 576 h to 520 h. Overall, it is shown that applying Bayes optimization allows for optimization of a multi-objective optimization function with several optimizable input variables and under a considerable amount of constraints with a low computational effort. This approach provides the potential to be used in the form of a decision tool, e.g., for the choice of an optimal and robust seed train design or for further optimization tasks within process development. article_number: '883' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Anton full_name: Sekulic, Anton last_name: Sekulic - first_name: Markus full_name: Lange-Hegermann, Markus id: '71761' last_name: Lange-Hegermann - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes. 2022;10(5). doi:10.3390/pr10050883 apa: Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes, 10(5), Article 883. https://doi.org/10.3390/pr10050883 bjps: Hernández Rodriguez T et al. (2022) Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes 10. chicago: Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann, and Björn Frahm. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Processes 10, no. 5 (2022). https://doi.org/10.3390/pr10050883. chicago-de: Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann und Björn Frahm. 2022. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes 10, Nr. 5. doi:10.3390/pr10050883, . din1505-2-1: 'Hernández Rodriguez, Tanja ; Sekulic, Anton ; Lange-Hegermann, Markus ; Frahm, Björn: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In: Processes Bd. 10. Basel, MDPI AG (2022), Nr. 5' havard: T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, Processes. 10 (2022). ieee: 'T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, and B. Frahm, “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design,” Processes, vol. 10, no. 5, Art. no. 883, 2022, doi: 10.3390/pr10050883.' mla: Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Processes, vol. 10, no. 5, 883, 2022, https://doi.org/10.3390/pr10050883. short: T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Processes 10 (2022). ufg: 'Hernández Rodriguez, Tanja u. a.: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, in: Processes 10 (2022), H. 5.' van: Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes. 2022;10(5). date_created: 2024-04-25T13:35:04Z date_updated: 2024-05-21T09:30:15Z department: - _id: DEP4000 doi: 10.3390/pr10050883 intvolume: ' 10' issue: '5' keyword: - Gaussian processes - Bayes optimization - Pareto optimization - multi-objective - cell culture - seed train language: - iso: eng place: Basel publication: Processes publication_identifier: eissn: - 2227-9717 publication_status: published publisher: MDPI AG status: public title: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design type: scientific_journal_article user_id: '83781' volume: 10 year: '2022' ... --- _id: '8024' abstract: - lang: eng text: 'For the optimization of the impinging round jet, the pressure force coefficient and drying energy consumption on the moving curved surface are set as the objective functions to be minimized simultaneously. SHERPA search algorithm is used to search for the optimal point from multiple objective tradeoff study (Pareto Front) method. It is found that the pressure force coefficient on the impingement surface is highly dependent on the jet to surface distance and jet angle, while the drying energy consumption is highly dependent on the jet to jet spacing. Generally, the best design study during the multi-objective optimization is found at the maximum jet to surface distance, jet to jet spacing and surface velocity, and also minimum inlet velocity and jet angle. ' article_number: '17' author: - first_name: Ali full_name: Chitsazan, Ali id: '66488' last_name: Chitsazan - first_name: Georg Heinrich full_name: Klepp, Georg Heinrich id: '49011' last_name: Klepp - first_name: Mohammad Esmaeil full_name: Chitsazan, Mohammad Esmaeil last_name: Chitsazan - first_name: Birgit full_name: Glasmacher, Birgit last_name: Glasmacher citation: ama: 'Chitsazan A, Klepp GH, Chitsazan ME, Glasmacher B. MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE. Frontiers in heat and mass transfer : FHMT ; an international journal . 2022;18. doi:10.5098/hmt.18.17' apa: 'Chitsazan, A., Klepp, G. H., Chitsazan, M. E., & Glasmacher, B. (2022). MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE. Frontiers in Heat and Mass Transfer : FHMT ; an International Journal , 18, Article 17. https://doi.org/10.5098/hmt.18.17' bjps: 'Chitsazan A et al. (2022) MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE. Frontiers in heat and mass transfer : FHMT ; an international journal 18.' chicago: 'Chitsazan, Ali, Georg Heinrich Klepp, Mohammad Esmaeil Chitsazan, and Birgit Glasmacher. “MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE.” Frontiers in Heat and Mass Transfer : FHMT ; an International Journal 18 (2022). https://doi.org/10.5098/hmt.18.17.' chicago-de: 'Chitsazan, Ali, Georg Heinrich Klepp, Mohammad Esmaeil Chitsazan und Birgit Glasmacher. 2022. MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE. Frontiers in heat and mass transfer : FHMT ; an international journal 18. doi:10.5098/hmt.18.17, .' din1505-2-1: 'Chitsazan, Ali ; Klepp, Georg Heinrich ; Chitsazan, Mohammad Esmaeil ; Glasmacher, Birgit: MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE. In: Frontiers in heat and mass transfer : FHMT ; an international journal Bd. 18. Columbia, Mo, Global Digital Centra (2022)' havard: 'A. Chitsazan, G.H. Klepp, M.E. Chitsazan, B. Glasmacher, MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE, Frontiers in Heat and Mass Transfer : FHMT ; an International Journal . 18 (2022).' ieee: 'A. Chitsazan, G. H. Klepp, M. E. Chitsazan, and B. Glasmacher, “MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE,” Frontiers in heat and mass transfer : FHMT ; an international journal , vol. 18, Art. no. 17, 2022, doi: 10.5098/hmt.18.17.' mla: 'Chitsazan, Ali, et al. “MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE.” Frontiers in Heat and Mass Transfer : FHMT ; an International Journal , vol. 18, 17, 2022, https://doi.org/10.5098/hmt.18.17.' short: 'A. Chitsazan, G.H. Klepp, M.E. Chitsazan, B. Glasmacher, Frontiers in Heat and Mass Transfer : FHMT ; an International Journal 18 (2022).' ufg: 'Chitsazan, Ali u. a.: MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE, in: Frontiers in heat and mass transfer : FHMT ; an international journal 18 (2022).' van: 'Chitsazan A, Klepp GH, Chitsazan ME, Glasmacher B. MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE. Frontiers in heat and mass transfer : FHMT ; an international journal . 2022;18.' date_created: 2022-05-08T13:55:00Z date_updated: 2024-08-08T12:43:11Z department: - _id: DEP6017 - _id: DEP6020 doi: 10.5098/hmt.18.17 intvolume: ' 18' keyword: - Multiple jets - Heat transfer - Pressure force - Energy consumption - Optimization language: - iso: eng place: Columbia, Mo publication: 'Frontiers in heat and mass transfer : FHMT ; an international journal ' publication_identifier: issn: - 2151-8629 publication_status: published publisher: Global Digital Centra quality_controlled: '1' status: public title: MULTI-OBJECTIVE OPTIMIZATION OF DRYING ENERGY CONSUMPTION AND JET IMPINGEMENT FORCE ON A MOVING CURVED SURFACE type: scientific_journal_article user_id: '83781' volume: 18 year: '2022' ... --- _id: '10193' abstract: - lang: eng text: Development and optimization of biopharmaceutical production processes with cell cultures is cost- and time-consuming and often performed rather empirically. Efficient optimization of multiple objectives such as process time, viable cell density, number of operating steps & cultivation scales, required medium, amount of product as well as product quality depicts a promising approach. This contribution presents a workflow which couples uncertainty-based upstream simulation and Bayes optimization using Gaussian processes. Its application is demonstrated in a simulation case study for a relevant industrial task in process development, the design of a robust cell culture expansion process (seed train), meaning that despite uncertainties and variabilities concerning cell growth, low variations of viable cell density during the seed train are obtained. Compared to a non-optimized reference seed train, the optimized process showed much lower deviation rates regarding viable cell densities (<10% instead of 41.7%) using five or four shake flask scales and seed train duration could be reduced by 56 h from 576 h to 520 h. Overall, it is shown that applying Bayes optimization allows for optimization of a multi-objective optimization function with several optimizable input variables and under a considerable amount of constraints with a low computational effort. This approach provides the potential to be used in the form of a decision tool, e.g., for the choice of an optimal and robust seed train design or for further optimization tasks within process development. author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Anton full_name: Sekulic, Anton last_name: Sekulic - first_name: Markus full_name: Lange-Hegermann, Markus id: '71761' last_name: Lange-Hegermann - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: 'Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner R, Möller J, eds. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Vol special issue. Processes : open access journal. MDPI; 2022:21-48. doi:https://doi.org/10.3390/pr10050883' apa: 'Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In R. Pörtner & J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue (pp. 21–48). MDPI. https://doi.org/10.3390/pr10050883' bjps: 'Hernández Rodriguez T et al. (2022) Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In Pörtner R and Möller J (eds), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue. Basel: MDPI, pp. 21–48.' chicago: 'Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann, and Björn Frahm. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” In Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, edited by Ralf Pörtner and Johannes Möller, special issue:21–48. Processes : Open Access Journal. Basel: MDPI, 2022. https://doi.org/10.3390/pr10050883.' chicago-de: 'Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann und Björn Frahm. 2022. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, hg. von Ralf Pörtner und Johannes Möller, special issue:21–48. Processes : open access journal. Basel: MDPI. doi:https://doi.org/10.3390/pr10050883, .' din1505-2-1: 'Hernández Rodriguez, Tanja ; Sekulic, Anton ; Lange-Hegermann, Markus ; Frahm, Björn: Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner, R. ; Möller, J. (Hrsg.): Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Processes : open access journal. Bd. special issue. Basel : MDPI, 2022, S. 21–48' havard: 'T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022: pp. 21–48.' ieee: 'T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, and B. Frahm, “Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design,” in Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue, R. Pörtner and J. Möller, Eds. Basel: MDPI, 2022, pp. 21–48. doi: https://doi.org/10.3390/pr10050883.' mla: Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, edited by Ralf Pörtner and Johannes Möller, vol. special issue, MDPI, 2022, pp. 21–48, https://doi.org/10.3390/pr10050883. short: 'T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022, pp. 21–48.' ufg: 'Hernández Rodriguez, Tanja u. a.: Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design, in: Pörtner, Ralf/Möller, Johannes (Hgg.): Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Band special issue, Basel 2022 (Processes : open access journal),  S. 21–48.' van: 'Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner R, Möller J, editors. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2022. p. 21–48. (Processes : open access journal; vol. special issue).' date_created: 2023-08-08T12:58:36Z date_updated: 2023-08-16T09:24:16Z department: - _id: DEP4000 doi: https://doi.org/10.3390/pr10050883 editor: - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Johannes full_name: Möller, Johannes last_name: Möller keyword: - Gaussian processes - Bayes optimization - Pareto optimization - multi-objective - cell culture - seed train language: - iso: eng page: 21-48 place: Basel publication: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing publication_identifier: eisbn: - 978-3-0365-5209-5 eissn: - 2227-9717 isbn: - 978-3-0365-5210-1 publication_status: published publisher: MDPI quality_controlled: '1' series_title: 'Processes : open access journal' status: public title: Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design type: book_chapter user_id: '83781' volume: special issue year: '2022' ... --- _id: '12801' abstract: - lang: eng text: The present contribution derives a theoretical framework for constructing novel geometrical constraints in the context of density-based topology optimization. Principally, the predefined geometrical dimensionality is enforced locally on the components of the optimized structures. These constraints are defined using the principal values (singular values) from a singular value decomposition of points clouds represented by elemental centroids and the corresponding relative density design variables. The proposed approach is numerically implemented for demonstrating the designing of lattice or membrane-like structures. Several numerical examples confirm the validity of the derived theoretical framework for geometric dimensionality control. article_number: '160' author: - first_name: Nikolai full_name: Gerzen, Nikolai id: '76704' last_name: Gerzen - first_name: Thorsten full_name: Mertins, Thorsten last_name: Mertins - first_name: Claus B. W. full_name: Pedersen, Claus B. W. last_name: Pedersen citation: ama: Gerzen N, Mertins T, Pedersen CBW. Geometric dimensionality control of structural components in topology optimization. Structural and Multidisciplinary Optimization. 2022;65(5). doi:10.1007/s00158-022-03252-7 apa: Gerzen, N., Mertins, T., & Pedersen, C. B. W. (2022). Geometric dimensionality control of structural components in topology optimization. Structural and Multidisciplinary Optimization, 65(5), Article 160. https://doi.org/10.1007/s00158-022-03252-7 bjps: Gerzen N, Mertins T and Pedersen CBW (2022) Geometric Dimensionality Control of Structural Components in Topology Optimization. Structural and Multidisciplinary Optimization 65. chicago: Gerzen, Nikolai, Thorsten Mertins, and Claus B. W. Pedersen. “Geometric Dimensionality Control of Structural Components in Topology Optimization.” Structural and Multidisciplinary Optimization 65, no. 5 (2022). https://doi.org/10.1007/s00158-022-03252-7. chicago-de: Gerzen, Nikolai, Thorsten Mertins und Claus B. W. Pedersen. 2022. Geometric dimensionality control of structural components in topology optimization. Structural and Multidisciplinary Optimization 65, Nr. 5. doi:10.1007/s00158-022-03252-7, . din1505-2-1: 'Gerzen, Nikolai ; Mertins, Thorsten ; Pedersen, Claus B. W.: Geometric dimensionality control of structural components in topology optimization. In: Structural and Multidisciplinary Optimization Bd. 65. Berlin, Springer Science and Business Media LLC (2022), Nr. 5' havard: N. Gerzen, T. Mertins, C.B.W. Pedersen, Geometric dimensionality control of structural components in topology optimization, Structural and Multidisciplinary Optimization. 65 (2022). ieee: 'N. Gerzen, T. Mertins, and C. B. W. Pedersen, “Geometric dimensionality control of structural components in topology optimization,” Structural and Multidisciplinary Optimization, vol. 65, no. 5, Art. no. 160, 2022, doi: 10.1007/s00158-022-03252-7.' mla: Gerzen, Nikolai, et al. “Geometric Dimensionality Control of Structural Components in Topology Optimization.” Structural and Multidisciplinary Optimization, vol. 65, no. 5, 160, 2022, https://doi.org/10.1007/s00158-022-03252-7. short: N. Gerzen, T. Mertins, C.B.W. Pedersen, Structural and Multidisciplinary Optimization 65 (2022). ufg: 'Gerzen, Nikolai/Mertins, Thorsten/Pedersen, Claus B.W.: Geometric dimensionality control of structural components in topology optimization, in: Structural and Multidisciplinary Optimization 65 (2022), H. 5.' van: Gerzen N, Mertins T, Pedersen CBW. Geometric dimensionality control of structural components in topology optimization. Structural and Multidisciplinary Optimization. 2022;65(5). date_created: 2025-04-16T05:58:58Z date_updated: 2025-06-26T13:39:04Z department: - _id: DEP3020 doi: 10.1007/s00158-022-03252-7 external_id: isi: - '000796069200001' intvolume: ' 65' isi: '1' issue: '5' keyword: - Manufacturing constraints - Topology optimization - Geometric constraints - Gradient based structural optimization - Lattice designing - Additive manufacturing language: - iso: eng place: Berlin publication: Structural and Multidisciplinary Optimization publication_identifier: eissn: - 1615-147X issn: - 1615-1488 publication_status: published publisher: Springer Science and Business Media LLC status: public title: Geometric dimensionality control of structural components in topology optimization type: scientific_journal_article user_id: '83781' volume: 65 year: '2022' ... --- _id: '12814' abstract: - lang: eng text: Plug-in hybrid electric vehicles (PHEVs) are developed to reduce fuel consumption and the emission of carbon dioxide. Common powertrain configurations of PHEVs (i.e., the configuration of the combustion engine, electric motor, and transmission) can be operated either in series, parallel, or power split hybrid mode, whereas powertrain configurations with multimode transmissions enable switching between those modes during vehicle operation. Hence, depending on the current operation state of the vehicle, the most appropriate mode in terms efficiency can be selected. This, however, requires an operating strategy, which controls the mode selection as well as the torque distribution between the combustion engine and electric motor with the aim of optimal battery depletion and minimal fuel consumption. A well-known approach is the equivalent consumption minimization strategy (ECMS). It can be applied by using optimizations based on a prediction of the future driving behavior. Since the outcome of the ECMS depends on the quality of this prediction, it is crucial to know how accurate the predictions must be in order to obtain acceptable results. In this contribution, various prediction methods and real-time capable ECMS implementations are analyzed and compared in terms of the achievable fuel economy. The basis for the analysis is a holistic model of a state-of-the-art PHEV powertrain configuration, comprising the multimode transmission, corresponding powertrain components, and representative real-world driving data. article_number: '2905' author: - first_name: Stefan full_name: Geng, Stefan id: '43696' last_name: Geng - first_name: Thomas full_name: Schulte, Thomas id: '46242' last_name: Schulte - first_name: Jürgen full_name: Maas, Jürgen id: '1827' last_name: Maas citation: ama: Geng S, Schulte T, Maas J. Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle. Applied Sciences. 2022;12(6). doi:10.3390/app12062905 apa: Geng, S., Schulte, T., & Maas, J. (2022). Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle. Applied Sciences, 12(6), Article 2905. https://doi.org/10.3390/app12062905 bjps: Geng S, Schulte T and Maas J (2022) Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle. Applied Sciences 12. chicago: Geng, Stefan, Thomas Schulte, and Jürgen Maas. “Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle.” Applied Sciences 12, no. 6 (2022). https://doi.org/10.3390/app12062905. chicago-de: Geng, Stefan, Thomas Schulte und Jürgen Maas. 2022. Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle. Applied Sciences 12, Nr. 6. doi:10.3390/app12062905, . din1505-2-1: 'Geng, Stefan ; Schulte, Thomas ; Maas, Jürgen: Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle. In: Applied Sciences Bd. 12. Basel, MDPI AG (2022), Nr. 6' havard: S. Geng, T. Schulte, J. Maas, Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle, Applied Sciences. 12 (2022). ieee: 'S. Geng, T. Schulte, and J. Maas, “Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle,” Applied Sciences, vol. 12, no. 6, Art. no. 2905, 2022, doi: 10.3390/app12062905.' mla: Geng, Stefan, et al. “Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle.” Applied Sciences, vol. 12, no. 6, 2905, 2022, https://doi.org/10.3390/app12062905. short: S. Geng, T. Schulte, J. Maas, Applied Sciences 12 (2022). ufg: 'Geng, Stefan/Schulte, Thomas/Maas, Jürgen: Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle, in: Applied Sciences 12 (2022), H. 6.' van: Geng S, Schulte T, Maas J. Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle. Applied Sciences. 2022;12(6). date_created: 2025-04-17T06:46:05Z date_updated: 2025-06-26T13:30:48Z department: - _id: DEP6020 doi: 10.3390/app12062905 external_id: isi: - '000776925600001' intvolume: ' 12' isi: '1' issue: '6' keyword: - PHEV - ECMS - multimode transmission - optimization - powertrain modeling language: - iso: eng place: Basel publication: Applied Sciences publication_identifier: eissn: - 2076-3417 publication_status: published publisher: MDPI AG status: public title: Model-Based Analysis of Different Equivalent Consumption Minimization Strategies for a Plug-In Hybrid Electric Vehicle type: scientific_journal_article user_id: '83781' volume: 12 year: '2022' ... --- _id: '12800' abstract: - lang: eng text: his paper presents the cognitive module of the Cognitive Architecture for Artificial Intelligence (CAAI) in cyber-physical production systems (CPPS). The goal of this architecture is to reduce the implementation effort of artificial intelligence (AI) algorithms in CPPS. Declarative user goals and the provided algorithm-knowledge base allow the dynamic pipeline orchestration and configuration. A big data platform (BDP) instantiates the pipelines and monitors the CPPS performance for further evaluation through the cognitive module. Thus, the cognitive module is able to select feasible and robust configurations for process pipelines in varying use cases. Furthermore, it automatically adapts the models and algorithms based on model quality and resource consumption. The cognitive module also instantiates additional pipelines to evaluate algorithms from different classes on test functions. CAAI relies on well-defined interfaces to enable the integration of additional modules and reduce implementation effort. Finally, an implementation based on Docker, Kubernetes, and Kafka for the virtualization and orchestration of the individual modules and as messaging technology for module communication is used to evaluate a real-world use case. author: - first_name: Jan full_name: Strohschein, Jan last_name: Strohschein - first_name: Andreas full_name: Fischbach, Andreas last_name: Fischbach - first_name: Andreas full_name: Bunte, Andreas id: '58885' last_name: Bunte - first_name: Heide full_name: Faeskorn-Woyke, Heide last_name: Faeskorn-Woyke - first_name: Natalia full_name: Moriz, Natalia id: '44238' last_name: Moriz - first_name: Thomas full_name: Bartz-Beielstein, Thomas last_name: Bartz-Beielstein citation: ama: Strohschein J, Fischbach A, Bunte A, Faeskorn-Woyke H, Moriz N, Bartz-Beielstein T. Cognitive capabilities for the CAAI in cyber-physical production systems. The International Journal of Advanced Manufacturing Technology. 2021;115(11-12):3513-3532. doi:10.1007/s00170-021-07248-3 apa: Strohschein, J., Fischbach, A., Bunte, A., Faeskorn-Woyke, H., Moriz, N., & Bartz-Beielstein, T. (2021). Cognitive capabilities for the CAAI in cyber-physical production systems. The International Journal of Advanced Manufacturing Technology, 115(11–12), 3513–3532. https://doi.org/10.1007/s00170-021-07248-3 bjps: Strohschein J et al. (2021) Cognitive Capabilities for the CAAI in Cyber-Physical Production Systems. The International Journal of Advanced Manufacturing Technology 115, 3513–3532. chicago: 'Strohschein, Jan, Andreas Fischbach, Andreas Bunte, Heide Faeskorn-Woyke, Natalia Moriz, and Thomas Bartz-Beielstein. “Cognitive Capabilities for the CAAI in Cyber-Physical Production Systems.” The International Journal of Advanced Manufacturing Technology 115, no. 11–12 (2021): 3513–32. https://doi.org/10.1007/s00170-021-07248-3.' chicago-de: 'Strohschein, Jan, Andreas Fischbach, Andreas Bunte, Heide Faeskorn-Woyke, Natalia Moriz und Thomas Bartz-Beielstein. 2021. Cognitive capabilities for the CAAI in cyber-physical production systems. The International Journal of Advanced Manufacturing Technology 115, Nr. 11–12: 3513–3532. doi:10.1007/s00170-021-07248-3, .' din1505-2-1: 'Strohschein, Jan ; Fischbach, Andreas ; Bunte, Andreas ; Faeskorn-Woyke, Heide ; Moriz, Natalia ; Bartz-Beielstein, Thomas: Cognitive capabilities for the CAAI in cyber-physical production systems. In: The International Journal of Advanced Manufacturing Technology Bd. 115. London [u.a.], Springer (2021), Nr. 11–12, S. 3513–3532' havard: J. Strohschein, A. Fischbach, A. Bunte, H. Faeskorn-Woyke, N. Moriz, T. Bartz-Beielstein, Cognitive capabilities for the CAAI in cyber-physical production systems, The International Journal of Advanced Manufacturing Technology. 115 (2021) 3513–3532. ieee: 'J. Strohschein, A. Fischbach, A. Bunte, H. Faeskorn-Woyke, N. Moriz, and T. Bartz-Beielstein, “Cognitive capabilities for the CAAI in cyber-physical production systems,” The International Journal of Advanced Manufacturing Technology, vol. 115, no. 11–12, pp. 3513–3532, 2021, doi: 10.1007/s00170-021-07248-3.' mla: Strohschein, Jan, et al. “Cognitive Capabilities for the CAAI in Cyber-Physical Production Systems.” The International Journal of Advanced Manufacturing Technology, vol. 115, no. 11–12, 2021, pp. 3513–32, https://doi.org/10.1007/s00170-021-07248-3. short: J. Strohschein, A. Fischbach, A. Bunte, H. Faeskorn-Woyke, N. Moriz, T. Bartz-Beielstein, The International Journal of Advanced Manufacturing Technology 115 (2021) 3513–3532. ufg: 'Strohschein, Jan u. a.: Cognitive capabilities for the CAAI in cyber-physical production systems, in: The International Journal of Advanced Manufacturing Technology 115 (2021), H. 11–12,  S. 3513–3532.' van: Strohschein J, Fischbach A, Bunte A, Faeskorn-Woyke H, Moriz N, Bartz-Beielstein T. Cognitive capabilities for the CAAI in cyber-physical production systems. The International Journal of Advanced Manufacturing Technology. 2021;115(11–12):3513–32. date_created: 2025-04-15T13:05:17Z date_updated: 2025-06-26T13:39:22Z department: - _id: DEP5023 doi: 10.1007/s00170-021-07248-3 external_id: isi: - '000659025000010' intvolume: ' 115' isi: '1' issue: 11-12 keyword: - Cognition - Industry 40 - Big data platform - Machine learning - CPPS - Optimization - Algorithm selection - Simulation language: - iso: eng page: 3513-3532 place: London [u.a.] publication: The International Journal of Advanced Manufacturing Technology publication_identifier: eissn: - 1433-3015 issn: - 0268-3768 publication_status: published publisher: 'Springer ' status: public title: Cognitive capabilities for the CAAI in cyber-physical production systems type: scientific_journal_article user_id: '83781' volume: 115 year: '2021' ... --- _id: '4518' abstract: - lang: eng text: This paper introduces CAAI, a novel cognitive architecture for artificial intelligence in cyber-physical production systems. The goal of the architecture is to reduce the implementation effort for the usage of artificial intelligence algorithms. The core of the CAAI is a cognitive module that processes the user's declarative goals, selects suitable models and algorithms, and creates a configuration for the execution of a processing pipeline on a big data platform. Constant observation and evaluation against performance criteria assess the performance of pipelines for many and different use cases. Based on these evaluations, the pipelines are automatically adapted if necessary. The modular design with well-defined interfaces enables the reusability and extensibility of pipeline components. A big data platform implements this modular design supported by technologies such as Docker, Kubernetes, and Kafka for virtualization and orchestration of the individual components and their communication. The implementation of the architecture is evaluated using a real-world use case. The prototypic implementation is accessible on GitHub and contains a demonstration. author: - first_name: Andreas full_name: Fischbach, Andreas last_name: Fischbach - first_name: Jan full_name: Strohschein, Jan last_name: Strohschein - first_name: Andreas full_name: Bunte, Andreas id: '58885' last_name: Bunte - first_name: Jörg full_name: Stork, Jörg last_name: Stork - first_name: Heide full_name: Faeskorn-Woyke, Heide last_name: Faeskorn-Woyke - first_name: Natalia full_name: Moriz, Natalia id: '44238' last_name: Moriz - first_name: Thomas full_name: Bartz-Beielstein, Thomas last_name: Bartz-Beielstein citation: ama: Fischbach A, Strohschein J, Bunte A, et al. CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems. The International Journal of Advanced Manufacturing Technology. 2020;111(1/2):609-626. doi:10.1007/s00170-020-06094-z apa: Fischbach, A., Strohschein, J., Bunte, A., Stork, J., Faeskorn-Woyke, H., Moriz, N., & Bartz-Beielstein, T. (2020). CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems. The International Journal of Advanced Manufacturing Technology, 111(1/2), 609–626. https://doi.org/10.1007/s00170-020-06094-z bjps: Fischbach A et al. (2020) CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems. The International Journal of Advanced Manufacturing Technology 111, 609–626. chicago: 'Fischbach, Andreas, Jan Strohschein, Andreas Bunte, Jörg Stork, Heide Faeskorn-Woyke, Natalia Moriz, and Thomas Bartz-Beielstein. “CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems.” The International Journal of Advanced Manufacturing Technology 111, no. 1/2 (2020): 609–26. https://doi.org/10.1007/s00170-020-06094-z.' chicago-de: 'Fischbach, Andreas, Jan Strohschein, Andreas Bunte, Jörg Stork, Heide Faeskorn-Woyke, Natalia Moriz und Thomas Bartz-Beielstein. 2020. CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems. The International Journal of Advanced Manufacturing Technology 111, Nr. 1/2: 609–626. doi:10.1007/s00170-020-06094-z, .' din1505-2-1: 'Fischbach, Andreas ; Strohschein, Jan ; Bunte, Andreas ; Stork, Jörg ; Faeskorn-Woyke, Heide ; Moriz, Natalia ; Bartz-Beielstein, Thomas: CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems. In: The International Journal of Advanced Manufacturing Technology Bd. 111, Springer (2020), Nr. 1/2, S. 609–626' havard: A. Fischbach, J. Strohschein, A. Bunte, J. Stork, H. Faeskorn-Woyke, N. Moriz, T. Bartz-Beielstein, CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems, The International Journal of Advanced Manufacturing Technology. 111 (2020) 609–626. ieee: 'A. Fischbach et al., “CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems,” The International Journal of Advanced Manufacturing Technology, vol. 111, no. 1/2, pp. 609–626, 2020, doi: 10.1007/s00170-020-06094-z.' mla: Fischbach, Andreas, et al. “CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems.” The International Journal of Advanced Manufacturing Technology, vol. 111, no. 1/2, 2020, pp. 609–26, https://doi.org/10.1007/s00170-020-06094-z. short: A. Fischbach, J. Strohschein, A. Bunte, J. Stork, H. Faeskorn-Woyke, N. Moriz, T. Bartz-Beielstein, The International Journal of Advanced Manufacturing Technology 111 (2020) 609–626. ufg: 'Fischbach, Andreas u. a.: CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems, in: The International Journal of Advanced Manufacturing Technology 111 (2020), H. 1/2,  S. 609–626.' van: Fischbach A, Strohschein J, Bunte A, Stork J, Faeskorn-Woyke H, Moriz N, et al. CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems. The International Journal of Advanced Manufacturing Technology. 2020;111(1/2):609–26. date_created: 2021-01-26T12:24:10Z date_updated: 2025-06-26T13:38:24Z department: - _id: DEP5023 doi: 10.1007/s00170-020-06094-z external_id: isi: - '000574389900002' intvolume: ' 111' isi: '1' issue: 1/2 keyword: - CPPS - Artificial intelligence - Industry 40 - Reference architecture - Optimization - SMBO - Cognition - Big data platform - Modularization - AutoML language: - iso: eng page: 609-626 publication: The International Journal of Advanced Manufacturing Technology publication_identifier: eissn: - 1433-3015 issn: - 0268-3768 publication_status: published publisher: Springer status: public title: CAAI -- A Cognitive Architecture to Introduce Artificial Intelligence in Cyber-Physical Production Systems type: journal_article user_id: '83781' volume: 111 year: '2020' ... --- _id: '5435' abstract: - lang: eng text: Towards renewable energy systems, the coupling of multiple sectors is important and incorporates novel technologies where currently no models exist that correctly represent all transient effects. Therefore, we present a method that incorporates Hardware-in-the-Loop simulations where virtual components as models are coupled to real and experimental facilities in real time. By including experimental components, a higher validity can be obtained and the practical applicability of renewable energy scenario can be discussed more profoundly. In this paper, the considered energy system consists of an experimental biocatalytic methanation reactor, a real photovoltaic park, a regenerative fuel cell and short-term storage units to supply a residential district. A representative control sequence of the methanator is obtained by modeling the scenario as an optimal control problem. A first HIL simulation highlights that modifications of the instrumentation are required for a grid injection of the generated methane. The scientific approach can be applied to any energy system where some of the considered components are available as experimental or real facilities. Non-exisiting components are simply replaced by models. The presented approach helps to determine which parts or process parameters are crucial for the planed operation before the overall energy system is realized on a larger scale. (C) 2019 Elsevier Ltd. All rights reserved. author: - first_name: Martin full_name: Griese, Martin id: '52308' last_name: Griese - first_name: Marc Philippe full_name: Hoffrath, Marc Philippe last_name: Hoffrath - first_name: Timo full_name: Broeker, Timo id: '43927' last_name: Broeker - first_name: Thomas full_name: Schulte, Thomas id: '46242' last_name: Schulte - first_name: Jan full_name: Schneider, Jan id: '13209' last_name: Schneider orcid: 0000-0001-6401-8873 citation: ama: 'Griese M, Hoffrath MP, Broeker T, Schulte T, Schneider J. Hardware-in-the-Loop simulation of an optimized energy management incorporating an experimental biocatalytic methanation reactor. Energy : the international journal. 2019;181:77-90. doi:10.1016/j.energy.2019.05.092' apa: 'Griese, M., Hoffrath, M. P., Broeker, T., Schulte, T., & Schneider, J. (2019). Hardware-in-the-Loop simulation of an optimized energy management incorporating an experimental biocatalytic methanation reactor. Energy : The International Journal, 181, 77–90. https://doi.org/10.1016/j.energy.2019.05.092' bjps: 'Griese M et al. (2019) Hardware-in-the-Loop Simulation of an Optimized Energy Management Incorporating an Experimental Biocatalytic Methanation Reactor. Energy : the international journal 181, 77–90.' chicago: 'Griese, Martin, Marc Philippe Hoffrath, Timo Broeker, Thomas Schulte, and Jan Schneider. “Hardware-in-the-Loop Simulation of an Optimized Energy Management Incorporating an Experimental Biocatalytic Methanation Reactor.” Energy : The International Journal 181 (2019): 77–90. https://doi.org/10.1016/j.energy.2019.05.092.' chicago-de: 'Griese, Martin, Marc Philippe Hoffrath, Timo Broeker, Thomas Schulte und Jan Schneider. 2019. Hardware-in-the-Loop simulation of an optimized energy management incorporating an experimental biocatalytic methanation reactor. Energy : the international journal 181: 77–90. doi:10.1016/j.energy.2019.05.092, .' din1505-2-1: 'Griese, Martin ; Hoffrath, Marc Philippe ; Broeker, Timo ; Schulte, Thomas ; Schneider, Jan: Hardware-in-the-Loop simulation of an optimized energy management incorporating an experimental biocatalytic methanation reactor. In: Energy : the international journal Bd. 181, Elsevier (2019), S. 77–90' havard: 'M. Griese, M.P. Hoffrath, T. Broeker, T. Schulte, J. Schneider, Hardware-in-the-Loop simulation of an optimized energy management incorporating an experimental biocatalytic methanation reactor, Energy : The International Journal. 181 (2019) 77–90.' ieee: 'M. Griese, M. P. Hoffrath, T. Broeker, T. Schulte, and J. Schneider, “Hardware-in-the-Loop simulation of an optimized energy management incorporating an experimental biocatalytic methanation reactor,” Energy : the international journal, vol. 181, pp. 77–90, 2019, doi: 10.1016/j.energy.2019.05.092.' mla: 'Griese, Martin, et al. “Hardware-in-the-Loop Simulation of an Optimized Energy Management Incorporating an Experimental Biocatalytic Methanation Reactor.” Energy : The International Journal, vol. 181, 2019, pp. 77–90, https://doi.org/10.1016/j.energy.2019.05.092.' short: 'M. Griese, M.P. Hoffrath, T. Broeker, T. Schulte, J. Schneider, Energy : The International Journal 181 (2019) 77–90.' ufg: 'Griese, Martin u. a.: Hardware-in-the-Loop simulation of an optimized energy management incorporating an experimental biocatalytic methanation reactor, in: Energy : the international journal 181 (2019),  S. 77–90.' van: 'Griese M, Hoffrath MP, Broeker T, Schulte T, Schneider J. Hardware-in-the-Loop simulation of an optimized energy management incorporating an experimental biocatalytic methanation reactor. Energy : the international journal. 2019;181:77–90.' conference: end_date: 2018-06-21 location: Guimaraes, PORTUGAL name: 31st International Conference on Efficiency, Cost, Optimization, Simulation, and Environmental Impact of Energy Systems (ECOS) start_date: 2018-06-17 date_created: 2021-04-08T07:42:48Z date_updated: 2025-06-25T07:48:53Z department: - _id: DEP4023 - _id: DEP4018 doi: 10.1016/j.energy.2019.05.092 external_id: isi: - '000476965900009' intvolume: ' 181' isi: '1' keyword: - Biological methanation - Energy management - HIL simulation - Optimization - Scalable models language: - iso: eng page: 77 - 90 publication: 'Energy : the international journal' publication_identifier: eissn: - 1873-6785 issn: - 0360-5442 publication_status: published publisher: Elsevier quality_controlled: '1' status: public title: Hardware-in-the-Loop simulation of an optimized energy management incorporating an experimental biocatalytic methanation reactor type: journal_article user_id: '83781' volume: 181 year: '2019' ... --- _id: '577' abstract: - lang: eng text: A rising number of product variants together with decreasing lot sizes are a result of the trend of individualization. Besides the upcoming organizational issues, changes in the production technologies are required. Direct digital manufacturing contributes to solve this problem by enabling the production of parts right from the CAD data.Process capability analysis is applied in several industries to prove the reliable compliance of products with quality requirements. As it is based on statistical methods, new challenges arise in the context of single-part production.The paper describes and compares different approaches for the adoption of process capability analysis for single-part production with special focus on additive manufacturing technologies. The statistical background and the applicability of different capability parameters are discussed. An overview of existing research work is given and supplemented by own approaches for the adoption of statistical methods for single-part production. The aim of the research work is to establish a first approach for the qualification of new technologies in single-part production. author: - first_name: Andrea full_name: Huxol, Andrea id: '43559' last_name: Huxol - first_name: Andrea full_name: Davis, Andrea id: '68611' last_name: Davis - first_name: Franz-Josef full_name: Villmer, Franz-Josef id: '14290' last_name: Villmer - first_name: Eva full_name: Scheideler, Eva id: '61522' last_name: Scheideler citation: ama: 'Huxol A, Davis A, Villmer F-J, Scheideler E. Deployment of Process Capability Analysis for Single-Part Production. In: Padoano E, Villmer F-J, Department of Production Engineering and Management, eds. Production Engineering and Management. Publication series in direct digital manufacturing . Lemgo; 2017:63-74.' apa: Huxol, A., Davis, A., Villmer, F.-J., & Scheideler, E. (2017). Deployment of Process Capability Analysis for Single-Part Production. In E. Padoano, F.-J. Villmer, & Department of Production Engineering and Management (Eds.), Production Engineering and Management (pp. 63–74). Lemgo. bjps: Huxol A et al. (2017) Deployment of Process Capability Analysis for Single-Part Production. In Padoano E, Villmer F-J and Department of Production Engineering and Management (eds), Production Engineering and Management. Lemgo, pp. 63–74. chicago: Huxol, Andrea, Andrea Davis, Franz-Josef Villmer, and Eva Scheideler. “Deployment of Process Capability Analysis for Single-Part Production.” In Production Engineering and Management, edited by Elio Padoano, Franz-Josef Villmer, and Department of Production Engineering and Management, 63–74. Publication Series in Direct Digital Manufacturing . Lemgo, 2017. chicago-de: 'Huxol, Andrea, Andrea Davis, Franz-Josef Villmer und Eva Scheideler. 2017. Deployment of Process Capability Analysis for Single-Part Production. In: Production Engineering and Management, hg. von Elio Padoano, Franz-Josef Villmer, und Department of Production Engineering and Management, 63–74. Publication series in direct digital manufacturing . Lemgo.' din1505-2-1: 'Huxol, Andrea ; Davis, Andrea ; Villmer, Franz-Josef ; Scheideler, Eva: Deployment of Process Capability Analysis for Single-Part Production. In: Padoano, E. ; Villmer, F.-J. ; Department of Production Engineering and Management (Hrsg.): Production Engineering and Management, Publication series in direct digital manufacturing . Lemgo, 2017, S. 63–74' havard: 'A. Huxol, A. Davis, F.-J. Villmer, E. Scheideler, Deployment of Process Capability Analysis for Single-Part Production, in: E. Padoano, F.-J. Villmer, Department of Production Engineering and Management (Eds.), Production Engineering and Management, Lemgo, 2017: pp. 63–74.' ieee: A. Huxol, A. Davis, F.-J. Villmer, and E. Scheideler, “Deployment of Process Capability Analysis for Single-Part Production,” in Production Engineering and Management, Pordenone, Italy, 2017, no. 1, pp. 63–74. mla: Huxol, Andrea, et al. “Deployment of Process Capability Analysis for Single-Part Production.” Production Engineering and Management, edited by Elio Padoano et al., no. 1, 2017, pp. 63–74. short: 'A. Huxol, A. Davis, F.-J. Villmer, E. Scheideler, in: E. Padoano, F.-J. Villmer, Department of Production Engineering and Management (Eds.), Production Engineering and Management, Lemgo, 2017, pp. 63–74.' ufg: 'Huxol, Andrea et. al. (2017): Deployment of Process Capability Analysis for Single-Part Production, in: Elio Padoano et. al. (Hgg.): Production Engineering and Management (=Publication series in direct digital manufacturing ), Lemgo, S. 63–74.' van: 'Huxol A, Davis A, Villmer F-J, Scheideler E. Deployment of Process Capability Analysis for Single-Part Production. In: Padoano E, Villmer F-J, Department of Production Engineering and Management, editors. Production Engineering and Management. Lemgo; 2017. p. 63–74. (Publication series in direct digital manufacturing ).' conference: end_date: 2017-09-29 location: Pordenone, Italy name: Proceedings7th International Conference start_date: 2017-09-28 corporate_editor: - Department of Production Engineering and Management - Hochschule Ostwestfalen-Lippe date_created: 2019-02-18T11:16:07Z date_updated: 2023-03-15T13:50:01Z department: - _id: DEP1306 editor: - first_name: Elio full_name: Padoano, Elio last_name: Padoano - first_name: Franz-Josef full_name: Villmer, Franz-Josef last_name: Villmer issue: '1' keyword: - Statistical process control - Process capability analysis - Single-part production - Process optimization language: - iso: eng main_file_link: - open_access: '1' url: https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_2017_Proceeding_web.pdf oa: '1' page: 63-74 place: Lemgo publication: Production Engineering and Management publication_identifier: isbn: - 978-3-946856-01-6 publication_status: published related_material: link: - relation: contains url: https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_2017_Proceeding_web.pdf series_title: 'Publication series in direct digital manufacturing ' status: public title: Deployment of Process Capability Analysis for Single-Part Production type: conference user_id: '45673' year: 2017 ... --- _id: '579' abstract: - lang: eng text: Selective Laser Melting (SLM) is a powder bed fusion process to produce additively metal parts. From the current point of view, it seems to be one of the most promising additive manufacturing technologies for the production of end use parts. An increasing number of examples prove the successful application of SLM for technical part production. Nevertheless, they also show the enormous effort that is still required to qualify the production process of every single part individually.The present paper gives an overview of the major influencing factors of the SLM process. To get a comprehensive research approach, existing publications on the topic are taken into account as well as own experimental work, evaluating the effects of the process parameters on the relative density of samples made from tool steel. The experimental setup and the results are described and opportunities for the further research work are discussed. author: - first_name: Andrea full_name: Huxol, Andrea id: '43559' last_name: Huxol - first_name: Eva full_name: Scheideler, Eva id: '61522' last_name: Scheideler - first_name: Franz-Josef full_name: Villmer, Franz-Josef id: '14290' last_name: Villmer citation: ama: 'Huxol A, Scheideler E, Villmer F-J. Influencing Factors on Part Quality in Selective Laser Melting. In: Padoano E, Villmer F-J, Department of Production Engineering and Management, eds. Production Engineering and Management. Lemgo; 2017:13-34.' apa: Huxol, A., Scheideler, E., & Villmer, F.-J. (2017). Influencing Factors on Part Quality in Selective Laser Melting. In E. Padoano, F.-J. Villmer, & Department of Production Engineering and Management (Eds.), Production Engineering and Management (pp. 13–34). Lemgo. bjps: Huxol A, Scheideler E and Villmer F-J (2017) Influencing Factors on Part Quality in Selective Laser Melting. In Padoano E, Villmer F-J and Department of Production Engineering and Management (eds), Production Engineering and Management. Lemgo, pp. 13–34. chicago: Huxol, Andrea, Eva Scheideler, and Franz-Josef Villmer. “Influencing Factors on Part Quality in Selective Laser Melting.” In Production Engineering and Management, edited by Elio Padoano, Franz-Josef Villmer, and Department of Production Engineering and Management, 13–34. Lemgo, 2017. chicago-de: 'Huxol, Andrea, Eva Scheideler und Franz-Josef Villmer. 2017. Influencing Factors on Part Quality in Selective Laser Melting. In: Production Engineering and Management, hg. von Elio Padoano, Franz-Josef Villmer, und Department of Production Engineering and Management, 13–34. Lemgo.' din1505-2-1: 'Huxol, Andrea ; Scheideler, Eva ; Villmer, Franz-Josef: Influencing Factors on Part Quality in Selective Laser Melting. In: Padoano, E. ; Villmer, F.-J. ; Department of Production Engineering and Management (Hrsg.): Production Engineering and Management. Lemgo, 2017, S. 13–34' havard: 'A. Huxol, E. Scheideler, F.-J. Villmer, Influencing Factors on Part Quality in Selective Laser Melting, in: E. Padoano, F.-J. Villmer, Department of Production Engineering and Management (Eds.), Production Engineering and Management, Lemgo, 2017: pp. 13–34.' ieee: A. Huxol, E. Scheideler, and F.-J. Villmer, “Influencing Factors on Part Quality in Selective Laser Melting,” in Production Engineering and Management, Pordenone, Italy, 2017, no. 1, pp. 13–34. mla: Huxol, Andrea, et al. “Influencing Factors on Part Quality in Selective Laser Melting.” Production Engineering and Management, edited by Elio Padoano et al., no. 1, 2017, pp. 13–34. short: 'A. Huxol, E. Scheideler, F.-J. Villmer, in: E. Padoano, F.-J. Villmer, Department of Production Engineering and Management (Eds.), Production Engineering and Management, Lemgo, 2017, pp. 13–34.' ufg: 'Huxol, Andrea et. al. (2017): Influencing Factors on Part Quality in Selective Laser Melting, in: Elio Padoano et. al. (Hgg.): Production Engineering and Management, Lemgo, S. 13–34.' van: 'Huxol A, Scheideler E, Villmer F-J. Influencing Factors on Part Quality in Selective Laser Melting. In: Padoano E, Villmer F-J, Department of Production Engineering and Management, editors. Production Engineering and Management. Lemgo; 2017. p. 13–34.' conference: end_date: 2017-09-29 location: Pordenone, Italy name: Proceedings 7th International Conference start_date: 2017-09-28 corporate_editor: - Department of Production Engineering and Management - Hochschule Ostwestfalen-Lippe date_created: 2019-02-18T11:34:36Z date_updated: 2023-03-15T13:50:02Z department: - _id: DEP1306 editor: - first_name: Elio full_name: Padoano, Elio last_name: Padoano - first_name: Franz-Josef full_name: Villmer, Franz-Josef last_name: Villmer issue: '1' keyword: - Selective laser melting - Additive manufacturing - Process parameters - Process optimization language: - iso: eng main_file_link: - open_access: '1' url: https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_2017_Proceeding_web.pdf oa: '1' page: 13-34 place: Lemgo publication: Production Engineering and Management publication_identifier: isbn: - 978-3-946856-01-6 publication_status: published related_material: link: - relation: contains url: https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_2017_Proceeding_web.pdf status: public title: Influencing Factors on Part Quality in Selective Laser Melting type: conference user_id: '45673' year: 2017 ... --- _id: '457' abstract: - lang: eng text: "Additive Manufacturing (AM) increasingly enables the realization of structures, which have a much greater freedom of design und can therefore better use nature \ as a design ideal. Bionic design principles have already been introduced \ into general design approaches, and several topology optimization systems (TO) are available today to increase structural stiffness and to enable lightweight \ design. AM and TO, used in synergy, promise completely new application areas. However, staircase effects resulting from a layer-by-layer build process \ and unavoidable support structures which must be mechanically removed afterwards are disadvantageous with respect to surface texture and strength properties.\r\nThe present article addresses the question of how far the notches resulting from the staircase effect of Additive Manufacturing and the support structures removed \ decrease the strength of components. Most engineers try to follow the inner flow of forces in a part’s design by smoothening surfaces in notched areas. Considering this, a elected component is investigated with finite element \ analysis (FEA) with special regard for the concentration of tress arising from surface notch effects. An outlook is given as regards how a reduction of the notch effect from the taircase effect can be achieved effectively." author: - first_name: Eva full_name: Scheideler, Eva id: '61522' last_name: Scheideler - first_name: Franz-Josef full_name: Villmer, Franz-Josef id: '14290' last_name: Villmer - first_name: G. full_name: Adam, G. last_name: Adam - first_name: Mirco full_name: Timmer, Mirco id: '69228' last_name: Timmer conference: end_date: 2016-09-30 location: Lemgo name: Proceedings 6th International Conference start_date: 2016-09-29 corporate_editor: - Department of Production Engineering and Management OWL University of Applied Sciences, Lemgo (Germany) - Hochschule Ostwestfalen-Lippe date_created: 2019-01-22T14:07:32Z date_updated: 2023-03-15T13:49:54Z department: - _id: DEP1306 editor: - first_name: Franz-Josef full_name: Villmer, Franz-Josef id: '14290' last_name: Villmer - first_name: Elio full_name: Padoano, Elio last_name: Padoano issue: '1' keyword: - Additive Manufacturing - Topology optimization - Staircase effect - Support structures - Stress concentration - Lightweight construction - Design rules - Notch effect language: - iso: eng main_file_link: - open_access: '1' url: https://www.th-owl.de/elsa/download/333/334/PEM_2016_Proceeding_2016_09_14_Inhaltsnavigation.pdf oa: '1' page: 39-50 place: Lemgo publication: Production Engineering and Management Proceedings 6th International Conference publication_identifier: isbn: - 978-3-946856-00-9 publication_status: published status: public title: Topology Optimization and Additive Manufacturing – A Perfect Symbiosis? type: conference user_id: '79260' year: 2016 ... --- _id: '598' abstract: - lang: eng text: "The aerospace sector is characterized by long product life cycles and a need for lightweight design. Additive manufacturing is a technology that produces parts layer by layer and thus enables the manufacturing of any complex parts at nearly no extra costs. A topology optimization enhances the part’s\r\nperformance for their special purpose. The results are often complex bionic structures that cannot be produced with conventional manufacturing technologies. The paper analyzes how the high potential of this technologycan be applied to aerospace parts. A topology optimization will be conducted for an aircraft part explaining the crucial points and a life cycle analysis examines the achieved sustainable improvements for the aircraft’s life cycle.\r\n" author: - first_name: Andrea full_name: Huxol, Andrea id: '43559' last_name: Huxol - first_name: Franz-Josef full_name: Villmer, Franz-Josef id: '14290' last_name: Villmer citation: ama: 'Huxol A, Villmer F-J. Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In: Padoano E, Villmer F-J, Department of Production Engineering and Management, eds. Production Engineering and Management. Lemgo; 2015:207-218.' apa: 'Huxol, A., & Villmer, F.-J. (2015). Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In E. Padoano, F.-J. Villmer, & Department of Production Engineering and Management (Eds.), Production Engineering and Management (pp. 207–218). Lemgo.' bjps: 'Huxol A and Villmer F-J (2015) Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In Padoano E, Villmer F-J and Department of Production Engineering and Management (eds), Production Engineering and Management. Lemgo, pp. 207–218.' chicago: 'Huxol, Andrea, and Franz-Josef Villmer. “Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies.” In Production Engineering and Management, edited by Elio Padoano, Franz-Josef Villmer, and Department of Production Engineering and Management, 207–18. Lemgo, 2015.' chicago-de: 'Huxol, Andrea und Franz-Josef Villmer. 2015. Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In: Production Engineering and Management, hg. von Elio Padoano, Franz-Josef Villmer, und Department of Production Engineering and Management, 207–218. Lemgo.' din1505-2-1: 'Huxol, Andrea ; Villmer, Franz-Josef: Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In: Padoano, E. ; Villmer, F.-J. ; Department of Production Engineering and Management (Hrsg.): Production Engineering and Management. Lemgo, 2015, S. 207–218' havard: 'A. Huxol, F.-J. Villmer, Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies, in: E. Padoano, F.-J. Villmer, Department of Production Engineering and Management (Eds.), Production Engineering and Management, Lemgo, 2015: pp. 207–218.' ieee: 'A. Huxol and F.-J. Villmer, “Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies,” in Production Engineering and Management, Trieste, Italy, 2015, no. 1, pp. 207–218.' mla: 'Huxol, Andrea, and Franz-Josef Villmer. “Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies.” Production Engineering and Management, edited by Elio Padoano et al., no. 1, 2015, pp. 207–18.' short: 'A. Huxol, F.-J. Villmer, in: E. Padoano, F.-J. Villmer, Department of Production Engineering and Management (Eds.), Production Engineering and Management, Lemgo, 2015, pp. 207–218.' ufg: 'Huxol, Andrea/Villmer, Franz-Josef (2015): Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies, in: Elio Padoano et. al. (Hgg.): Production Engineering and Management, Lemgo, S. 207–218.' van: 'Huxol A, Villmer F-J. Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies. In: Padoano E, Villmer F-J, Department of Production Engineering and Management, editors. Production Engineering and Management. Lemgo; 2015. p. 207–18.' conference: end_date: 2015-10-02 location: Trieste, Italy name: Proceedings5th International Conference start_date: 2015-10-01 corporate_editor: - Department of Production Engineering and Management - Hochschule Ostwestfalen-Lippe date_created: 2019-02-19T07:26:35Z date_updated: 2023-03-15T13:50:03Z department: - _id: DEP1306 editor: - first_name: Elio full_name: Padoano, Elio last_name: Padoano - first_name: Franz-Josef full_name: Villmer, Franz-Josef last_name: Villmer issue: '1' keyword: - Additive manufacturing - topology optimization - aerospace - life cycle costs language: - iso: eng main_file_link: - open_access: '1' url: https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_Tagung_zusammen2015.pdf oa: '1' page: 207-218 place: Lemgo publication: Production Engineering and Management publication_identifier: isbn: - 978-3-941645-11-0 publication_status: published related_material: link: - relation: contains url: https://www.hs-owl.de/fileadmin/diman/Veroeffentlichungen/PEM_Tagung_zusammen2015.pdf status: public title: 'Hybrid Manufacturing Machines: Combining Additive and Subtractive Manufacturing Technologies' type: conference user_id: '45673' year: 2015 ... --- _id: '2394' abstract: - lang: eng text: For the production of biopharmaceuticals a seed train is required to generate an adequate number of cells for inoculation of the production bioreactor. This seed train is time- and cost-intensive but offers potential for optimization. A method and a protocol are described for the seed train mapping, directed modeling without major effort, and its optimization regarding selected optimization criteria such as optimal points in time for cell passaging. Furthermore, the method can also be applied for the set-up of a new seed train, for example for a new cell line. Although the chapter is directed towards suspension cell lines, the method is also generally applicable, e.g. for adherent cell lines. author: - first_name: Björn full_name: Frahm, Björn last_name: Frahm citation: ama: 'Frahm B. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology. Vol 1104. Methods in Molecular Biology . Totowa, NJ: Humana Press; 2013:355-367. doi:10.1007/978-1-62703-733-4_22' apa: 'Frahm, B. (2013). Seed Train Optimization for Cell Culture. In Animal Cell Biotechnology (Vol. 1104, pp. 355–367). Totowa, NJ: Humana Press. https://doi.org/10.1007/978-1-62703-733-4_22' bjps: 'Frahm B (2013) Seed Train Optimization for Cell Culture. Animal Cell Biotechnology, vol. 1104. Totowa, NJ: Humana Press, pp. 355–367.' chicago: 'Frahm, Björn. “Seed Train Optimization for Cell Culture.” In Animal Cell Biotechnology, 1104:355–67. Methods in Molecular Biology . Totowa, NJ: Humana Press, 2013. https://doi.org/10.1007/978-1-62703-733-4_22.' chicago-de: 'Frahm, Björn. 2013. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology, 1104:355–367. Methods in Molecular Biology . Totowa, NJ: Humana Press. doi:10.1007/978-1-62703-733-4_22, .' din1505-2-1: 'Frahm, Björn: Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology, Methods in Molecular Biology . Bd. 1104. Totowa, NJ : Humana Press, 2013, S. 355–367' havard: 'B. Frahm, Seed Train Optimization for Cell Culture, in: Animal Cell Biotechnology, Humana Press, Totowa, NJ, 2013: pp. 355–367.' ieee: 'B. Frahm, “Seed Train Optimization for Cell Culture,” in Animal Cell Biotechnology, vol. 1104, Totowa, NJ: Humana Press, 2013, pp. 355–367.' mla: Frahm, Björn. “Seed Train Optimization for Cell Culture.” Animal Cell Biotechnology, vol. 1104, Humana Press, 2013, pp. 355–67, doi:10.1007/978-1-62703-733-4_22. short: 'B. Frahm, in: Animal Cell Biotechnology, Humana Press, Totowa, NJ, 2013, pp. 355–367.' ufg: 'Frahm, Björn (2013): Seed Train Optimization for Cell Culture, in: Animal Cell Biotechnology (=Methods in Molecular Biology 1104), Totowa, NJ, S. 355–367.' van: 'Frahm B. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology. Totowa, NJ: Humana Press; 2013. p. 355–67. (Methods in Molecular Biology ; vol. 1104).' date_created: 2020-05-19T14:45:43Z date_updated: 2023-03-15T13:49:39Z department: - _id: DEP4021 doi: 10.1007/978-1-62703-733-4_22 intvolume: ' 1104' keyword: - Seed train Optimization Modeling Prediction Space-Time-Yield (STY) Systems approach Bioinformatics Computational biotechnology Suspension Production language: - iso: eng page: 355-367 place: Totowa, NJ publication: Animal Cell Biotechnology publication_identifier: eisbn: - '9781627037334' isbn: - '9781627037327' issn: - 1064-3745 - 1940-6029 publication_status: published publisher: Humana Press series_title: 'Methods in Molecular Biology ' status: public title: Seed Train Optimization for Cell Culture type: book_chapter user_id: '74004' volume: 1104 year: 2013 ... --- _id: '10214' abstract: - lang: eng text: For the production of biopharmaceuticals a seed train is required to generate an adequate number of cells for inoculation of the production bioreactor. This seed train is time- and cost-intensive but offers potential for optimization. A method and a protocol are described for the seed train mapping, directed modeling without major effort, and its optimization regarding selected optimization criteria such as optimal points in time for cell passaging. Furthermore, the method can also be applied for the set-up of a new seed train, for example for a new cell line. Although the chapter is directed towards suspension cell lines, the method is also generally applicable, e.g. for adherent cell lines. author: - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: 'Frahm B. Seed Train Optimization for Cell Culture. In: Pörtner R, ed. Animal Cell Biotechnology - Methods and Protocols. Vol 1104. 3rd ed. Methods in Molecular Biology. Humana Press; 2013:355-367. doi:10.1007/978-1-62703-733-4_22' apa: Frahm, B. (2013). Seed Train Optimization for Cell Culture. In R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols (3rd ed., Vol. 1104, pp. 355–367). Humana Press. https://doi.org/10.1007/978-1-62703-733-4_22 bjps: 'Frahm B (2013) Seed Train Optimization for Cell Culture. In Pörtner R (ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., vol. 1104. Totowa, NJ: Humana Press, pp. 355–367.' chicago: 'Frahm, Björn. “Seed Train Optimization for Cell Culture.” In Animal Cell Biotechnology - Methods and Protocols, edited by Ralf Pörtner, 3rd ed., 1104:355–67. Methods in Molecular Biology. Totowa, NJ: Humana Press, 2013. https://doi.org/10.1007/978-1-62703-733-4_22.' chicago-de: 'Frahm, Björn. 2013. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology - Methods and Protocols, hg. von Ralf Pörtner, 1104:355–367. 3. Aufl. Methods in Molecular Biology. Totowa, NJ: Humana Press. doi:10.1007/978-1-62703-733-4_22, .' din1505-2-1: 'Frahm, Björn: Seed Train Optimization for Cell Culture. In: Pörtner, R. (Hrsg.): Animal Cell Biotechnology - Methods and Protocols, Methods in Molecular Biology. Bd. 1104. 3. Aufl. Totowa, NJ : Humana Press, 2013, S. 355–367' havard: 'B. Frahm, Seed Train Optimization for Cell Culture, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013: pp. 355–367.' ieee: 'B. Frahm, “Seed Train Optimization for Cell Culture,” in Animal Cell Biotechnology - Methods and Protocols, 3rd ed., vol. 1104, R. Pörtner, Ed. Totowa, NJ: Humana Press, 2013, pp. 355–367. doi: 10.1007/978-1-62703-733-4_22.' mla: Frahm, Björn. “Seed Train Optimization for Cell Culture.” Animal Cell Biotechnology - Methods and Protocols, edited by Ralf Pörtner, 3rd ed., vol. 1104, Humana Press, 2013, pp. 355–67, https://doi.org/10.1007/978-1-62703-733-4_22. short: 'B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013, pp. 355–367.' ufg: 'Frahm, Björn: Seed Train Optimization for Cell Culture, in: Pörtner, Ralf (Hg.): Animal Cell Biotechnology - Methods and Protocols, Bd. 1104, Totowa, NJ 32013 (Methods in Molecular Biology),  S. 355–367.' van: 'Frahm B. Seed Train Optimization for Cell Culture. In: Pörtner R, editor. Animal Cell Biotechnology - Methods and Protocols. 3rd ed. Totowa, NJ: Humana Press; 2013. p. 355–67. (Methods in Molecular Biology; vol. 1104).' date_created: 2023-08-14T17:50:56Z date_updated: 2023-08-16T06:41:21Z department: - _id: DEP4000 doi: 10.1007/978-1-62703-733-4_22 edition: '3' editor: - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner intvolume: ' 1104' keyword: - Seed train - Optimization - Modeling - Prediction - Space-Time-Yield (STY) - Systems approach - Bioinformatics - Computational biotechnology - Suspension - Production language: - iso: eng page: 355–367 place: Totowa, NJ publication: Animal Cell Biotechnology - Methods and Protocols publication_identifier: eisbn: - 978-1-62703-733-4 eissn: - 1940-6029 isbn: - 978-1-62703-732-7 issn: - 1064-3745 publication_status: published publisher: Humana Press series_title: Methods in Molecular Biology status: public title: Seed Train Optimization for Cell Culture type: book_chapter user_id: '83781' volume: 1104 year: '2013' ...