@inbook{7983, abstract = {{For the manufacturing of complex biopharmaceuticals using bioreactors with cultivated mammalian cells, high product concentration is an important objective. The phenotype of the cells in a reactor plays an important role. Are clonal cell populations showing high cell-specific growth rates more favorable than cell lines with higher cell-specific productivities or vice versa? Five clonal Chinese hamster ovary cell populations were analyzed based on the data of a 3-month-stability study. We adapted a mechanistic cell culture model to the experimental data of one such clonally derived cell population. Uncertainties and prior knowledge concerning model parameters were considered using Bayesian parameter estimations. This model was used then to define an inoculum train protocol. Based on this, we subsequently simulated the impacts of differences in growth rates (±10%) and production rates (±10% and ±50%) on the overall cultivation time, including making the inoculum train cultures; the final production phase, the volumetric titer in that bioreactor and the ratio of both, defined as overall process productivity. We showed thus unequivocally that growth rates have a higher impact (up to three times) on overall process productivity and for product output per year, whereas cells with higher productivity can potentially generate higher product concentrations in the production vessel.}}, author = {{Hernández Rodriguez, Tanja and Morerod, Sophie and Pörtner, Ralf and Wurm, Florian M. and Frahm, Björn}}, booktitle = {{Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing}}, isbn = {{978-3-0365-5210-1}}, issn = {{2227-9717 }}, keywords = {{clonal cell population, phenotypic diversity, inoculum train, uncertainty-based, cell culture model, biopharmaceutical manufacturing}}, pages = {{49--74}}, publisher = {{MDPI}}, title = {{{Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study}}}, doi = {{10.3390/pr9060964}}, volume = {{special issue}}, year = {{2021}}, } @inbook{6910, abstract = {{AI is on the rise. Powerful cloud platforms and networked software components can perform increasingly complex data evaluations and simulations. Recent research and development projects1 show how great the potential of artificial intelligence is for urban planning. However, despite the impressive, technical possibilities, it currently remains unclear how planning stakeholders and the affected population can be meaningfully involved in the intelligent processes of the "black box". The authors are of the opinion that sustainable urban development planning not only requires acceptance of the spatial planning result, as has been the case up to now, but also requires acceptance of the increasingly digitally supported planning process. For this reason, it must also be possible for laypersons to understand the digital analysis and evaluation processes and to comprehend their relevance and spatial interactions. Consequently, simulations must not only run in the computers of the respective planning or engineering offices, but require a simple, haptic analog translation that can also be used in participation processes as already shown in the CityScope projects2. For this project, the big revitalization project of Deutzer Hafen in Cologne to a future district with more than 9.500 daily users is used as a case study in building a decision support system for urban planning. It is composed of three parts: an agent-based model, a tangible user interface and a synthetic population. The project enables users to get in touch with an agent-based model (ABM) without any knowledge in coding or even interacting with computers. It connects physical objects to digital information. Based on the theories of Castiglione et.al.3 , Gehl4 , Shannon5 and Jacobs6 this project shows how to use an artificial and analog simulation model to measure the urban vitality of the public spaces in the district, based on the activity and travelling patterns of the population. This is done by testing different scenarios in which we change interactive parameters of the model: the use of the buildings and the demographics of the population. We can then determine which scenarios benefit the most life in the public spaces of the district, by finding areas of interest or problematic ones. }}, author = {{Barbosa Jardim, Amanda and Müh, Maximilian and Häusler, Axel and Kondziela, Andrea}}, booktitle = {{ REAL CORP 2021: Cities 20.50, creating habitats for the 3rd millennium, smart - sustainable - climate neutral : proceedings of 26th International Conference on Urban Planning, Regional Development and Information Society}}, editor = {{Schrenk, Manfred and Popovich, Vasily V. and Zeile, Peter and Elisei, Pietro and Beyer, Clemens and Ryser, Judith and Stöglehner, Gernot}}, isbn = {{978-3-9504945-0-1}}, keywords = {{mart Cities, Agent-based modelling, KI/AI, Participation, Tangible Data}}, location = {{Wien}}, publisher = {{CORP - Competence Center of Urban and Regional Planning}}, title = {{{Synthetic and Tangible Agents for an Activity-based Urban Planning Tool}}}, doi = {{10.48494/REALCORP2021.1049}}, year = {{2021}}, } @inbook{3349, abstract = {{Model-based concepts and simulation techniques in combination with digital tools emerge as a key to explore the full potential of biopharmaceutical production processes, which contain several challenging development and process steps. One of these steps is the time- and cost-intensive cell proliferation process (also called seed train) to increase cell number from cell thawing up to production scale. Challenges like complex cell metabolism, batch-to-batch variation, variabilities in cell behavior, and influences of changes in cultivation conditions necessitate adequate digital solutions to provide information about the current and near future process state to derive correct process decisions. For this purpose digital seed train twins have proved to be efficient, which digitally display the time-dependent behavior of important process variables based on mathematical models, strategies, and adaption procedures. This chapter will outline the needs for digitalization of seed trains, the construction of a digital seed train twin, the role of parameter estimation, and different statistical methods within this context, which are applicable to several problems in the field of bioprocessing. The results of a case study are presented to illustrate a Bayesian approach for parameter estimation and prediction of an industrial cell culture seed train for seed train digitalization.}}, author = {{Hernández Rodriguez, Tanja and Frahm, Björn}}, booktitle = {{Digital Twins Tools and Concepts for Smart Biomanufacturing}}, editor = {{Herwig, Christoph and Pörtner, Ralf and Möller, Johannes }}, isbn = {{978-3-030-71659-2}}, issn = {{1616-8542}}, keywords = {{Bayes, Digital twin, Parameter estimation, Seed train, Uncertainty}}, pages = {{97–131}}, publisher = {{Springer}}, title = {{{Digital Seed Train Twins and Statistical Methods}}}, doi = {{https://doi.org/10.1007/10_2020_137}}, volume = {{176}}, year = {{2021}}, } @misc{4100, author = {{Schmohl, Tobias and Schwickert, Susanne and Glahn, Oliver}}, booktitle = {{The Future of Education}}, keywords = {{Artificial Intelligence, intelligent tutoring system, reflection, project-based learning, online-learning, interactive video}}, location = {{Florenz}}, pages = {{309--313}}, publisher = {{Libreriauniversitaria.it}}, title = {{{Conceptual Design of an AI-Based Learning Assistant }}}, doi = {{10.26352/E618_2384-9509}}, year = {{2020}}, } @inbook{4312, abstract = {{Computer-aided assistance systems are entering the world of work and production. Such systems utilize augmented- and virtual-reality for operator training and live guidance as well as mobile maintenance and support. This is particularly important in the modern production reality of ever-changing products and `lot size one' customization of production.This paper focuses on the application of machine learning approach to extend the functionality of assistance systems. Machine learning provides tools to analyse large amounts of data and extract meaningful information. The goal here is to recognize the movement of an operator which would enable automatic display of instructions relevant to them.We present the challenges facing machine learning applications in human-centered assistance systems and a framework to assess machine learning approaches feasible for this scenario. The approach is assessed on a historical data set and then deployed in a work station for live testing. The post-hoc, or historical, analysis yields promising results. The ad-hoc, or live, analysis is a complex task and the results are affected by multiple factors, most of which are introduced by the human influence.The contribution of this paper is an approach to adapt state- of-the-art machine learning to operator movement recognition with a special focus on approaches to spatial time series data pre-processing. Presented experiment results validate the approach and show that it performs well in a real-world scenario.}}, author = {{Fullen, Marta and Maier, Alexander and Nazarenko, Arthur and Jenderny, Sascha and Röcker, Carsten}}, booktitle = {{2019 IEEE 17th International Conference on Industrial Informatics (INDIN)}}, isbn = {{978-1-7281-2927-3}}, issn = {{2378-363X}}, keywords = {{augmented reality, computer based training, data handling, industrial training, learning (artificial intelligence), time series}}, location = {{Helsinki, Finland,}}, pages = {{296 -- 302}}, publisher = {{IEEE}}, title = {{{Machine Learning for Assistance Systems: Pattern-Based Approach to Online Step Recognition}}}, doi = {{10.1109/INDIN41052.2019.8972122}}, year = {{2019}}, } @inbook{4313, abstract = {{This paper reports on a study (N = 471) exploring the acceptance of video-based home monitoring systems as well as criteria influencing their acceptance. While most participants stated that they would home monitoring solutions under certain conditions, the majority of participants is rather reluctant to use systems that transmit visual and acoustical information to remote medical personnel. Besides age, most user characteristics, which played important roles in technology acceptance research for many years, do not appear to be decisive factors for the acceptance of electronic home-monitoring services.}}, author = {{Röcker, Carsten}}, booktitle = {{Intelligent Human Systems Integration 2019}}, editor = {{Karwowski, Waldemar and Ahram, Tareq}}, isbn = {{978-3-030-11050-5}}, keywords = {{Active assisted living, Electronic homecare, e-health : Video-based monitoring, Technology acceptance, User-centered design, Study}}, location = {{San Diego, California, USA}}, pages = {{551 -- 556}}, publisher = {{Springer}}, title = {{{Exploring the Acceptance of Video-Based Medical Support}}}, doi = {{10.1007/978-3-030-11051-2_83}}, volume = {{903}}, year = {{2019}}, } @article{5736, abstract = {{Ein Blick auf Deutschland von oben und in unsere Planungswerkzeuge wie die BauNVO zeigt, auch Jahrzehnte nach dem Leitbild der Stadt der kurzen Wege abseits von Innenstädten und so mancher Großstadt, noch das Bild einer sortierten Stadt. Die Gegenbewegung zur autogerechten Stadt setzte in den 1980er Jahren ein und verfolgt im Kern ein diametral entgegengesetztes Ziel – die fußläufige Stadt. Doch auch über 30 Jahre später zeigt sich abseits der Innenstädte in den umliegenden Stadtteilen und Dörfern noch ein ernüchterndes monofunktionales Bild. Dabei sind es genau diese räumlichen Einheiten, die in etwa dem fußläufigen Bewegungsradius seiner Bewohner entsprechen. Hier - von der eigenen Wohnung aus erreichbar - braucht es Angebote für die Ziele des Alltags. Inzwischen belegen zahlreiche Studien die Möglichkeiten und Vorteile kompakter nutzungsgemischter Quartiere in ökologischer, sozialer und ökonomischer Hinsicht. Diese Größeneinheit hat ein prominentes Vorbild: Die mittelalterliche europäische Stadt. Mit diesem Perspektivwechsel wird die Stadt von vorgestern zur Vorlage für das Quartier von übermorgen. Zweitveröffentlichung bei polis: https://polis-magazin.com/2019/10/quartier-der-kurzen-wege-die-stadt-von-vorgestern-als-quartier-von-uebermorgen/ }}, author = {{Cardinali, Marcel}}, issn = {{2566-8900}}, journal = {{urbanLab Magazin - Fachzeitschrift für Stadt- und Regionalplanung}}, keywords = {{Quartiersentwicklung, Nachhaltigkeit, Stadt der kurzen Wege, Doppelte Innenentwicklung, Nature-based Solutions, Lebensqualität}}, number = {{5}}, pages = {{26--37}}, publisher = {{Technische Hochschule Ostwestfalen-Lippe}}, title = {{{Quartier der kurzen Wege - Die Stadt von vorgestern ist das Quartier von übermorgen}}}, year = {{2019}}, } @article{2014, abstract = {{Industrial applications are in transition towards modular and flexible architectures that are capable of self-configuration and -optimisation. This is due to the demand of mass customisation and the increasing complexity of industrial systems. The conversion to modular systems is related to challenges in all disciplines. Consequently, diverse tasks such as information processing, extensive networking, or system monitoring using sensor and information fusion systems need to be reconsidered. The focus of this contribution is on distributed sensor and information fusion systems for system monitoring, which must reflect the increasing flexibility of fusion systems. This contribution thus proposes an approach, which relies on a network of self-descriptive intelligent sensor nodes, for the automatic design and update of sensor and information fusion systems. This article encompasses the fusion system configuration and adaptation as well as communication aspects. Manual interaction with the flexibly changing system is reduced to a minimum.}}, author = {{Fritze, Alexander and Mönks, Uwe and Holst, Christoph-Alexander and Lohweg, Volker}}, issn = {{1424-8220}}, journal = {{Sensors}}, keywords = {{information fusion, intelligent sensor, knowledge-based system, self-configuration, sensor fusion}}, number = {{3}}, title = {{{An Approach to Automated Fusion System Design and Adaptation}}}, doi = {{ https://doi.org/10.3390/s17030601}}, volume = {{17}}, year = {{2017}}, } @inproceedings{265, abstract = {{The maintenance of a tool for injection molding or forming is usually accompanied by its disassembly and assembly. The duration of the assembly activities is often a large part of the total activity time for the maintenance of the tool. The degree of performance of the employees in the execution of these disassembly and assembly activities is often low. In addition, allowances occur (e.g. searching for work equipment). At the Industrial Engineering Lab of the Ostwestfalen-Lippe University of Applied Sciences, a prototype of an assistance system was developed to support the assembly activities in toolmaking. With the help of this system, the operator is guided step by step through the assembly process. The economic potential of the system exists in the reduction of training times, the avoidance of assembly errors and the increase of labor productivity.}}, author = {{Hinrichsen, Sven and Riediger, Daniel and Unrau, Alexander}}, booktitle = {{2017 IEEE International Conference on Industrial Engineering and Engineering Management (IEEM)}}, isbn = {{978-1-5386-0948-4 }}, keywords = {{injection moulding, machine tools, maintenance engineering, productivity, projection-based assistance system, injection molding tools, assembly activities, assembly process, assembly errors, tool maintenance, disassembly activities, economic potential, Industrial Engineering Lab, Ostwestfalen-Lippe University of Applied Sciences, toolmaking, Tools, Injection molding, Maintenance engineering, Usability, Task analysis, Workstations, Morphology, assembly assistance systems, assistance systems, maintenance of injection molding tools, manual assembly}}, location = {{Singapore}}, number = {{1}}, pages = {{1571--1575}}, title = {{{Development of a Projection-Based Assistance System for Maintaining Injection Molding Tools}}}, doi = {{https://doi.org/10.1109/IEEM.2017.8290157}}, year = {{2017}}, } @inproceedings{4303, abstract = {{The increasing demand to customize products affects production workers in many industries, as assembly tasks become more complex due to higher product variety. Assistive systems providing instructions at the workplace have been proposed to overcome increasing cognitive demand during assembly tasks. Commercially available assistive systems provide spatially registered instructions, either by using in-situ projections or head-mounted displays (HMDs). As there is little empirical knowledge about the individual advantages and disadvantages of both approaches, we are interested in comparing both types of systems. Through a user study at a manual assembly workplace, we compare both approaches to a paper baseline. Our results reveal that both in-situ instructions and paper instructions lead to significantly faster task completion times and significantly fewer errors than HMDs. Using additional questionnaires and interviews, we are able to identify the shortcomings of HMD-based instructions and discuss the possibilities of using flexible in-situ instructions for worker assistance.}}, author = {{Büttner, Sebastian and Funk, Markus and Sand, Oliver and Röcker, Carsten}}, booktitle = {{9th ACM International Conference on PErvasive Technologies Related to Assistive Environments (PETRA '16) }}, isbn = {{978-1-4503-4337-4}}, keywords = {{Spatial Augmented Reality, Industrial Augmented Reality, Projection-based Augmented Reality, Head-Mounted Display, Manufacturing, Assistive System}}, location = {{Corfu; Greece }}, pages = {{1--8}}, publisher = {{ACM}}, title = {{{Using Head-Mounted Displays and In-Situ Projection for Assistive Systems : A Comparison}}}, doi = {{10.1145/2910674.2910679}}, year = {{2016}}, } @inproceedings{4674, abstract = {{More and more knowledge-based enterprises start to integrate Ambient Intelligence technologies into their business processes. While the usage of such technologies can lead to considerable benefits in a variety of business areas, the envisioned applications have to meet fundamental user needs, otherwise the negative side effects will overshadow the prospective benefits. This paper illustrates the benefits as well as potential risks of implementing Ambient Intelligence applications in knowledge-based enterprises and identifies the crucial aspects of successful system design.}}, author = {{Röcker, Carsten}}, booktitle = {{Proceedings of the International Conference on Economics, Business, Management and Marketing (EBMM'09), October 9 -11, Singapore, pp. 17 - 21}}, isbn = {{978-9-8108-3816-4 }}, keywords = {{Ambient Intelligence, Ubiquitous Computing, Technology-Enhanced Environments, Smart Spaces, Intellectual Teamwork, Knowledge-Based Enterprises}}, location = {{Signapore}}, pages = {{17--21}}, title = {{{Toward Smart Office Environments - Benefits and Drawbacks of Using Ambient Intelligence Technologies in Knowledge-Based Enterprises}}}, year = {{2009}}, } @inproceedings{4830, abstract = {{We present a ubiquitous computing environment that consists of the Hello.Wall in combination with ViewPorts. Hello.Wall is a new wall-sized ambient display [4,2] that emits information via light patterns and is considered informative art. As an integral part of the physical environment, Hello.Wall constitutes a seeding element of a social architectural space conveying awareness information and atmospheres in organizations or at specific places. The display is context-dependent by reflecting identity and distance of people passing by. Hello.Wall can "borrow" other artefacts in order to communicate more detailed information. These mobile devices are called ViewPorts. People can also further interact with the Hello.Wall using ViewPorts via integrated WaveLAN and RFID technology.}}, author = {{Prante, Thorsten and Röcker, Carsten and Streitz, Norbert and Stenzel, Richard and Magerkurth, Carsten and van Alphen, Daniel and Plewe, D. A.}}, booktitle = {{Video Track and Adjunct Proceedings of the Fifth International Conference on Ubiquitous Computing (UBICOMP’03)}}, editor = {{Ljungstrand, P. and Brotherton, J.}}, keywords = {{Ambient display, informative art, social architectural space, context-dependent, sensor-based interaction, interactive wall, interaction design, mobile devices, smart artefacts, ubiquitous computing environment, calm technology}}, location = {{Seattle, Washington, USA,}}, pages = {{277--278}}, title = {{{Hello.Wall – Beyond Ambient Displays}}}, year = {{2003}}, }