[{"abstract":[{"text":"In the context of data-driven bioprocess modeling, selecting appropriate regression models remains a critical challenge. This is especially the case when dealing with time-dependent process dynamics and complex measurement data. The practical relevance of this study lies in its critical assessment of the application constraints associated with multivariate linear regression models in bioprocess monitoring of cell culture processes. The applicability of Partial Least Squares and Ridge regression was evaluated for different cultivation phases. The results emphasize that no single linear modeling approach is universally suitable for capturing the complex behavior of mammalian cell cultures. This is why we present an enhanced segmented modeling approach by learning the optimal transition point from data and introducing a gradual model switch, allowing for smoother and more robust adaptation to process dynamics. This segmented model led to improved predictive performance compared to single-model regression across the entire process duration. Nevertheless, the heterogeneity of the 11 mammalian cell culture datasets used in this study posed significant challenges, with the best-performing models achieving prediction error of around 0.31 of the average offline viable cell density. These results underline the potential of phase-adaptive modeling, while also emphasizing the need for further optimization to robustly handle diverse bioprocess conditions.","lang":"eng"}],"department":[{"_id":"DEP4028"}],"conference":{"location":"Chemnitz","name":"2025 International Workshop on Impedance Spectroscopy (IWIS)","end_date":"2025-09-26","start_date":"2025-09-23"},"author":[{"orcid":"https://orcid.org/0000-0002-0502-8032","id":"68713","first_name":"Selina","last_name":"Uhlendorff","full_name":"Uhlendorff, Selina"},{"first_name":"Tatsiana","full_name":"Burankova, Tatsiana","last_name":"Burankova"},{"last_name":"Dahlmann","full_name":"Dahlmann, Katharina","first_name":"Katharina"},{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"orcid":"0000-0002-7920-0595","full_name":"Pein-Hackelbusch, Miriam","first_name":"Miriam","last_name":"Pein-Hackelbusch","id":"64952"}],"year":"2026","publisher":"IEEE","page":"34-39","status":"public","title":"Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis","publication_status":"published","citation":{"din1505-2-1":"Uhlendorff, Selina ; Burankova, Tatsiana ; Dahlmann, Katharina ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. New York : IEEE, 2026","chicago-de":"Uhlendorff, Selina, Tatsiana Burankova, Katharina Dahlmann, Björn Frahm und Miriam Pein-Hackelbusch. 2026. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. 2025 International Workshop on Impedance Spectroscopy (IWIS). New York: IEEE. doi:10.1109/iwis69004.2025.11339388, .","short":"S. Uhlendorff, T. Burankova, K. Dahlmann, B. Frahm, M. Pein-Hackelbusch, Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, IEEE, New York, 2026.","chicago":"Uhlendorff, Selina, Tatsiana Burankova, Katharina Dahlmann, Björn Frahm, and Miriam Pein-Hackelbusch. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. 2025 International Workshop on Impedance Spectroscopy (IWIS). New York: IEEE, 2026. https://doi.org/10.1109/iwis69004.2025.11339388.","ieee":"S. Uhlendorff, T. Burankova, K. Dahlmann, B. Frahm, and M. Pein-Hackelbusch, Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. New York: IEEE, 2026, pp. 34–39. doi: 10.1109/iwis69004.2025.11339388.","apa":"Uhlendorff, S., Burankova, T., Dahlmann, K., Frahm, B., & Pein-Hackelbusch, M. (2026). Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. In 2025 International Workshop on Impedance Spectroscopy (IWIS) (pp. 34–39). IEEE. https://doi.org/10.1109/iwis69004.2025.11339388","mla":"Uhlendorff, Selina, et al. “Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis.” 2025 International Workshop on Impedance Spectroscopy (IWIS), IEEE, 2026, pp. 34–39, https://doi.org/10.1109/iwis69004.2025.11339388.","bjps":"Uhlendorff S et al. (2026) Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. New York: IEEE.","havard":"S. Uhlendorff, T. Burankova, K. Dahlmann, B. Frahm, M. Pein-Hackelbusch, Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, IEEE, New York, 2026.","ufg":"Uhlendorff, Selina u. a.: Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, New York 2026.","ama":"Uhlendorff S, Burankova T, Dahlmann K, Frahm B, Pein-Hackelbusch M. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. IEEE; 2026:34-39. doi:10.1109/iwis69004.2025.11339388","van":"Uhlendorff S, Burankova T, Dahlmann K, Frahm B, Pein-Hackelbusch M. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. 2025 International Workshop on Impedance Spectroscopy (IWIS). New York: IEEE; 2026."},"doi":"10.1109/iwis69004.2025.11339388","_id":"13475","language":[{"iso":"eng"}],"keyword":["cell culture","impedance spectroscopy","partial least squares","ridge regression"],"place":"New York","date_created":"2026-03-06T08:52:51Z","type":"conference_editor_article","publication_identifier":{"isbn":["979-8-3315-9323-0"],"eisbn":["979-8-3315-9322-3"]},"publication":"2025 International Workshop on Impedance Spectroscopy (IWIS)","date_updated":"2026-03-10T13:55:42Z","user_id":"89807"},{"_id":"13651","language":[{"iso":"eng"}],"intvolume":" 2","date_updated":"2026-03-27T17:29:40Z","user_id":"45666","type":"scientific_journal_article","date_created":"2026-03-27T17:29:35Z","publication":"SeAMK Journal","quality_controlled":"1","publisher":"SeAMK","status":"public","issue":"1","department":[{"_id":"DEP4000"}],"year":"2025","main_file_link":[{"url":"https://lehti.seamk.fi/journal/demonstration-of-listeria-innocua-and-escherichia-coli-growth-in-ready-to-eat-vegan-foods/"}],"author":[{"last_name":"Müller","full_name":"Müller, Carolin","first_name":"Carolin"},{"last_name":"Alarinta","first_name":"Jarmo","full_name":"Alarinta, Jarmo"},{"first_name":"Björn","id":"45666","last_name":"Frahm","full_name":"Frahm, Björn"},{"full_name":"Wirtanen, Gun","first_name":"Gun","last_name":"Wirtanen"}],"article_type":"original","citation":{"apa":"Müller, C., Alarinta, J., Frahm, B., & Wirtanen, G. (2025). Demonstration of Listeria innocua and Escherichia coli growth in ready-to-eat vegan foods. SeAMK Journal, 2(1).","ieee":"C. Müller, J. Alarinta, B. Frahm, and G. Wirtanen, “Demonstration of Listeria innocua and Escherichia coli growth in ready-to-eat vegan foods,” SeAMK Journal, vol. 2, no. 1, 2025.","chicago":"Müller, Carolin, Jarmo Alarinta, Björn Frahm, and Gun Wirtanen. “Demonstration of Listeria Innocua and Escherichia Coli Growth in Ready-to-Eat Vegan Foods.” SeAMK Journal 2, no. 1 (2025).","van":"Müller C, Alarinta J, Frahm B, Wirtanen G. Demonstration of Listeria innocua and Escherichia coli growth in ready-to-eat vegan foods. SeAMK Journal. 2025;2(1).","ama":"Müller C, Alarinta J, Frahm B, Wirtanen G. Demonstration of Listeria innocua and Escherichia coli growth in ready-to-eat vegan foods. SeAMK Journal. 2025;2(1).","ufg":"Müller, Carolin u. a.: Demonstration of Listeria innocua and Escherichia coli growth in ready-to-eat vegan foods, in: SeAMK Journal 2 (2025), H. 1.","havard":"C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Demonstration of Listeria innocua and Escherichia coli growth in ready-to-eat vegan foods, SeAMK Journal. 2 (2025).","mla":"Müller, Carolin, et al. “Demonstration of Listeria Innocua and Escherichia Coli Growth in Ready-to-Eat Vegan Foods.” SeAMK Journal, vol. 2, no. 1, 2025.","bjps":"Müller C et al. (2025) Demonstration of Listeria Innocua and Escherichia Coli Growth in Ready-to-Eat Vegan Foods. SeAMK Journal 2.","short":"C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, SeAMK Journal 2 (2025).","chicago-de":"Müller, Carolin, Jarmo Alarinta, Björn Frahm und Gun Wirtanen. 2025. Demonstration of Listeria innocua and Escherichia coli growth in ready-to-eat vegan foods. SeAMK Journal 2, Nr. 1.","din1505-2-1":"Müller, Carolin ; Alarinta, Jarmo ; Frahm, Björn ; Wirtanen, Gun: Demonstration of Listeria innocua and Escherichia coli growth in ready-to-eat vegan foods. In: SeAMK Journal Bd. 2, SeAMK (2025), Nr. 1"},"volume":2,"title":"Demonstration of Listeria innocua and Escherichia coli growth in ready-to-eat vegan foods"},{"citation":{"ieee":"T. Hernández Rodríguez and B. Frahm, “Digitale Seed Train Zwillinge und statistische Methoden,” in Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, C. Herwig, R. Pörtner, and J. Möller, Eds. Berlin, Heidelberg: Springer , 2025, pp. 107–145. doi: doi.org/10.1007/978-3-031-75698-6.","ama":"Hernández Rodríguez T, Frahm B. Digitale Seed Train Zwillinge und statistische Methoden. In: Herwig C, Pörtner R, Möller J, eds. Digitale Zwillinge - Werkzeuge Und Konzepte Für Intelligente Bioproduktion. Advances in Biochemical Engineering/Biotechnology. 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Springer . https://doi.org/doi.org/10.1007/978-3-031-75698-6","ufg":"Hernández Rodríguez, Tanja/Frahm, Björn: Digitale Seed Train Zwillinge und statistische Methoden, in: Herwig, Christoph/Pörtner, Ralf/Möller, Johannes (Hgg.): Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, Berlin, Heidelberg 2025 (Advances in Biochemical Engineering/Biotechnology), S. 107–145.","mla":"Hernández Rodríguez, Tanja, and Björn Frahm. “Digitale Seed Train Zwillinge Und Statistische Methoden.” Digitale Zwillinge - Werkzeuge Und Konzepte Für Intelligente Bioproduktion, edited by Christoph Herwig et al., Springer , 2025, pp. 107–45, https://doi.org/doi.org/10.1007/978-3-031-75698-6.","bjps":"Hernández Rodríguez T and Frahm B (2025) Digitale Seed Train Zwillinge Und Statistische Methoden. In Herwig C, Pörtner R and Möller J (eds), Digitale Zwillinge - Werkzeuge Und Konzepte Für Intelligente Bioproduktion. Berlin, Heidelberg: Springer , pp. 107–145.","havard":"T. Hernández Rodríguez, B. Frahm, Digitale Seed Train Zwillinge und statistische Methoden, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digitale Zwillinge - Werkzeuge Und Konzepte Für Intelligente Bioproduktion, Springer , Berlin, Heidelberg, 2025: pp. 107–145.","van":"Hernández Rodríguez T, Frahm B. Digitale Seed Train Zwillinge und statistische Methoden. In: Herwig C, Pörtner R, Möller J, editors. Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion. Berlin, Heidelberg: Springer ; 2025. p. 107–45. (Advances in Biochemical Engineering/Biotechnology)."},"series_title":"Advances in Biochemical Engineering/Biotechnology","title":"Digitale Seed Train Zwillinge und statistische Methoden","page":"107-145","status":"public","quality_controlled":"1","publisher":"Springer ","department":[{"_id":"DEP4000"}],"year":"2025","author":[{"first_name":"Tanja","full_name":"Hernández Rodríguez, Tanja","last_name":"Hernández Rodríguez"},{"first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm","id":"45666"}],"date_updated":"2026-03-27T17:45:08Z","user_id":"45666","editor":[{"full_name":"Herwig, Christoph","first_name":"Christoph","last_name":"Herwig"},{"first_name":"Ralf","full_name":"Pörtner, Ralf","last_name":"Pörtner"},{"first_name":"Johannes","last_name":"Möller","full_name":"Möller, Johannes"}],"type":"book_chapter","date_created":"2026-03-27T17:45:02Z","publication":"Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion","publication_identifier":{"isbn":["978-3-031-75697-9"],"eisbn":["978-3-031-75698-6"]},"language":[{"iso":"eng"}],"place":"Berlin, Heidelberg","doi":"doi.org/10.1007/978-3-031-75698-6","_id":"13652"},{"_id":"13653","language":[{"iso":"eng"}],"date_created":"2026-03-27T17:49:49Z","type":"conference_speech","user_id":"45666","date_updated":"2026-03-27T17:49:53Z","author":[{"first_name":"Mario","full_name":"Luttmann, Mario","last_name":"Luttmann","id":"63215"},{"full_name":"Blome, André","first_name":"André","id":"62117","last_name":"Blome"},{"full_name":"Müller, Niklas","first_name":"Niklas","id":"85568","last_name":"Müller"},{"id":"85737","full_name":"Naqvi, Syeda Khadeeja","last_name":"Naqvi","first_name":"Syeda Khadeeja"},{"first_name":"Alexander","full_name":"Kutter, Alexander","id":"83513","last_name":"Kutter"},{"last_name":"Jekle","full_name":"Jekle, Mario","first_name":"Mario"},{"full_name":"Müller, Ulrich","first_name":"Ulrich","id":"12119","last_name":"Müller"},{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"}],"year":"2025","conference":{"location":"Detmold, Germany","name":"76. Tagung für Bäckerei-Technologie der AGF - Arbeitsgemeinschaft Getreideforschung e.V. in Zusammenarbeit mit dem Max Rubner-Institut, Institut für Sicherheit und Qualität bei Getreide","start_date":"11.11.2025","end_date":"12.11.2025"},"department":[{"_id":"DEP4000"}],"status":"public","title":"Einblicke in die objektive Bewertung von Weizenbrötchen in der virtuellen Realität","citation":{"short":"M. Luttmann, A. Blome, N. Müller, S.K. Naqvi, A. Kutter, M. Jekle, U. Müller, B. Frahm, Einblicke in Die Objektive Bewertung von Weizenbrötchen in Der Virtuellen Realität, 2025.","din1505-2-1":"Luttmann, Mario ; Blome, André ; Müller, Niklas ; Naqvi, Syeda Khadeeja ; Kutter, Alexander ; Jekle, Mario ; Müller, Ulrich ; Frahm, Björn: Einblicke in die objektive Bewertung von Weizenbrötchen in der virtuellen Realität, 2025","chicago-de":"Luttmann, Mario, André Blome, Niklas Müller, Syeda Khadeeja Naqvi, Alexander Kutter, Mario Jekle, Ulrich Müller und Björn Frahm. 2025. Einblicke in die objektive Bewertung von Weizenbrötchen in der virtuellen Realität.","apa":"Luttmann, M., Blome, A., Müller, N., Naqvi, S. K., Kutter, A., Jekle, M., Müller, U., & Frahm, B. (2025). Einblicke in die objektive Bewertung von Weizenbrötchen in der virtuellen Realität. 76. Tagung für Bäckerei-Technologie der AGF - Arbeitsgemeinschaft Getreideforschung e.V. in Zusammenarbeit mit dem Max Rubner-Institut, Institut für Sicherheit und Qualität bei Getreide, Detmold, Germany.","chicago":"Luttmann, Mario, André Blome, Niklas Müller, Syeda Khadeeja Naqvi, Alexander Kutter, Mario Jekle, Ulrich Müller, and Björn Frahm. Einblicke in Die Objektive Bewertung von Weizenbrötchen in Der Virtuellen Realität, 2025.","van":"Luttmann M, Blome A, Müller N, Naqvi SK, Kutter A, Jekle M, et al. Einblicke in die objektive Bewertung von Weizenbrötchen in der virtuellen Realität. 2025.","havard":"M. Luttmann, A. Blome, N. Müller, S.K. Naqvi, A. Kutter, M. Jekle, U. Müller, B. Frahm, Einblicke in die objektive Bewertung von Weizenbrötchen in der virtuellen Realität, 2025.","mla":"Luttmann, Mario, et al. Einblicke in Die Objektive Bewertung von Weizenbrötchen in Der Virtuellen Realität. 2025.","bjps":"Luttmann M et al. (2025) Einblicke in Die Objektive Bewertung von Weizenbrötchen in Der Virtuellen Realität. .","ufg":"Luttmann, Mario u. a.: Einblicke in die objektive Bewertung von Weizenbrötchen in der virtuellen Realität, o. O. 2025.","ieee":"M. Luttmann et al., Einblicke in die objektive Bewertung von Weizenbrötchen in der virtuellen Realität. 2025.","ama":"Luttmann M, Blome A, Müller N, et al. Einblicke in Die Objektive Bewertung von Weizenbrötchen in Der Virtuellen Realität.; 2025."}},{"language":[{"iso":"eng"}],"_id":"13654","user_id":"45666","date_updated":"2026-03-27T17:56:10Z","date_created":"2026-03-27T17:53:32Z","type":"conference_speech","status":"public","author":[{"first_name":"Mario","last_name":"Luttmann","full_name":"Luttmann, Mario","id":"63215"},{"id":"62117","first_name":"André","last_name":"Blome","full_name":"Blome, André"},{"id":"83513","first_name":"Alexander","last_name":"Kutter","full_name":"Kutter, Alexander"},{"full_name":"Naqvi, Syeda Khadeeja","id":"85737","last_name":"Naqvi","first_name":"Syeda Khadeeja"},{"id":"85568","full_name":"Müller, Niklas","first_name":"Niklas","last_name":"Müller"},{"first_name":"Mario","full_name":"Jekle, Mario","last_name":"Jekle"},{"last_name":"Frahm","full_name":"Frahm, Björn","id":"45666","first_name":"Björn"},{"id":"12119","first_name":"Ulrich","last_name":"Müller","full_name":"Müller, Ulrich"}],"year":"2025","conference":{"name":"Digital Twin Day","location":"Lemgo, Germany","start_date":"7.10.2025","end_date":"7.10.2025"},"department":[{"_id":"DEP4000"}],"citation":{"ama":"Luttmann M, Blome A, Kutter A, et al. 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Digital Twin Day, Lemgo, Germany.","chicago":"Luttmann, Mario, André Blome, Alexander Kutter, Syeda Khadeeja Naqvi, Niklas Müller, Mario Jekle, Björn Frahm, and Ulrich Müller. Qualitätskontrolle von Backwaren in Der Virtuellen Realität, 2025.","short":"M. Luttmann, A. Blome, A. Kutter, S.K. Naqvi, N. Müller, M. Jekle, B. Frahm, U. Müller, Qualitätskontrolle von Backwaren in Der Virtuellen Realität, 2025.","din1505-2-1":"Luttmann, Mario ; Blome, André ; Kutter, Alexander ; Naqvi, Syeda Khadeeja ; Müller, Niklas ; Jekle, Mario ; Frahm, Björn ; Müller, Ulrich: Qualitätskontrolle von Backwaren in der virtuellen Realität, 2025","chicago-de":"Luttmann, Mario, André Blome, Alexander Kutter, Syeda Khadeeja Naqvi, Niklas Müller, Mario Jekle, Björn Frahm und Ulrich Müller. 2025. Qualitätskontrolle von Backwaren in der virtuellen Realität."},"title":"Qualitätskontrolle von Backwaren in der virtuellen Realität"},{"type":"conference_speech","date_created":"2026-03-27T17:56:03Z","user_id":"45666","date_updated":"2026-03-27T17:56:07Z","language":[{"iso":"eng"}],"_id":"13655","title":"Weizenkleingebäck und Photogrammetrie: Einblicke in die bildbasierte Analyse von Backwaren","citation":{"din1505-2-1":"Luttmann, Mario ; Blome, André ; Jekle, Mario ; Frahm, Björn ; Müller, Ulrich: Weizenkleingebäck und Photogrammetrie: Einblicke in die bildbasierte Analyse von Backwaren, 2025","chicago-de":"Luttmann, Mario, André Blome, Mario Jekle, Björn Frahm und Ulrich Müller. 2025. Weizenkleingebäck und Photogrammetrie: Einblicke in die bildbasierte Analyse von Backwaren.","short":"M. Luttmann, A. Blome, M. Jekle, B. Frahm, U. 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Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. Chemie Ingenieur Technik. 2025;98(1-2):57-68. doi:10.1002/cite.70048","ieee":"S. Uhlendorff, U. Odefey, B. Frahm, and M. Pein-Hackelbusch, “Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture,” Chemie Ingenieur Technik, vol. 98, no. 1–2, pp. 57–68, 2025, doi: 10.1002/cite.70048.","din1505-2-1":"Uhlendorff, Selina ; Odefey, Ulrich ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. In: Chemie Ingenieur Technik Bd. 98. Weinheim, Wiley (2025), Nr. 1–2, S. 57–68","chicago-de":"Uhlendorff, Selina, Ulrich Odefey, Björn Frahm und Miriam Pein-Hackelbusch. 2025. Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. Chemie Ingenieur Technik 98, Nr. 1–2: 57–68. doi:10.1002/cite.70048, .","short":"S. Uhlendorff, U. Odefey, B. Frahm, M. Pein-Hackelbusch, Chemie Ingenieur Technik 98 (2025) 57–68.","ufg":"Uhlendorff, Selina u. a.: Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture, in: Chemie Ingenieur Technik 98 (2025), H. 1–2, S. 57–68.","bjps":"Uhlendorff S et al. (2025) Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. Chemie Ingenieur Technik 98, 57–68.","havard":"S. Uhlendorff, U. Odefey, B. Frahm, M. Pein-Hackelbusch, Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture, Chemie Ingenieur Technik. 98 (2025) 57–68.","mla":"Uhlendorff, Selina, et al. “Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture.” Chemie Ingenieur Technik, vol. 98, no. 1–2, 2025, pp. 57–68, https://doi.org/10.1002/cite.70048.","van":"Uhlendorff S, Odefey U, Frahm B, Pein-Hackelbusch M. Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. Chemie Ingenieur Technik. 2025;98(1–2):57–68.","chicago":"Uhlendorff, Selina, Ulrich Odefey, Björn Frahm, and Miriam Pein-Hackelbusch. “Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture.” Chemie Ingenieur Technik 98, no. 1–2 (2025): 57–68. https://doi.org/10.1002/cite.70048.","apa":"Uhlendorff, S., Odefey, U., Frahm, B., & Pein-Hackelbusch, M. (2025). Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. Chemie Ingenieur Technik, 98(1–2), 57–68. https://doi.org/10.1002/cite.70048"},"volume":98,"main_file_link":[{"open_access":"1"}],"author":[{"last_name":"Uhlendorff","id":"68713","full_name":"Uhlendorff, Selina","first_name":"Selina","orcid":"https://orcid.org/0000-0002-0502-8032"},{"last_name":"Odefey","full_name":"Odefey, Ulrich","id":"74218","first_name":"Ulrich"},{"first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm","id":"45666"},{"orcid":"0000-0002-7920-0595","id":"64952","first_name":"Miriam","last_name":"Pein-Hackelbusch","full_name":"Pein-Hackelbusch, Miriam"}],"year":"2025","page":"57–68","status":"public","type":"scientific_journal_article","intvolume":" 98","user_id":"45666","doi":"10.1002/cite.70048","_id":"13315","place":"Weinheim","publication_status":"published","issue":"1-2","abstract":[{"text":"Determining cell density and viability with (semi‐)automated methods enables rapid cell cultivation analysis. However, scientific validation is required, typically by comparing results to manual counting. To address this, we present a method to evaluate and compare two cell counting methods exemplified by a manual and a semi‐automated method (Countstar BioTech). Experiments followed validation parameters aligned with the International Council for Harmonization (ICH) Q2(R1) guideline and a dilution series design based on ISO 20391‐2:2019. Both the semi‐automated and manual methods showed comparable specificity and linearity for Chinese hamster ovary (CHO)‐K1 cells. The semi‐automated method exhibited superior repeatability for total cell density, whereas cell viability results showed no significant difference.","lang":"eng"}],"department":[{"_id":"DEP4029"},{"_id":"DEP4028"}],"quality_controlled":"1","publisher":"Wiley"},{"date_updated":"2025-10-17T18:22:39Z","user_id":"81304","date_created":"2024-11-06T16:53:13Z","type":"conference_speech","_id":"12021","language":[{"iso":"ger"}],"keyword":["sourdough","fermentation","near-infrared spectroscopy","support vector machine"],"publication_status":"published","citation":{"ama":"Segermann J, Luttmann M, Blome A, et al. Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie.; 2024.","ieee":"J. Segermann et al., Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie. 2024.","mla":"Segermann, Jan, et al. 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Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie. 2024.","chicago":"Segermann, Jan, Mario Luttmann, André Blome, Sebastian Feldt, Sujee Sivanesan, Christoph-Alexander Holst, Volker Lohweg, Björn Frahm, and Ulrich Müller. Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie, 2024.","apa":"Segermann, J., Luttmann, M., Blome, A., Feldt, S., Sivanesan, S., Holst, C.-A., Lohweg, V., Frahm, B., & Müller, U. (2024). Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie. 10. GDL Kongress Lebensmitteltechnologie 2024, Lemgo.","chicago-de":"Segermann, Jan, Mario Luttmann, André Blome, Sebastian Feldt, Sujee Sivanesan, Christoph-Alexander Holst, Volker Lohweg, Björn Frahm und Ulrich Müller. 2024. Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie.","din1505-2-1":"Segermann, Jan ; Luttmann, Mario ; Blome, André ; Feldt, Sebastian ; Sivanesan, Sujee ; Holst, Christoph-Alexander ; Lohweg, Volker ; Frahm, Björn ; u. a.: Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie, 2024","short":"J. Segermann, M. Luttmann, A. Blome, S. Feldt, S. Sivanesan, C.-A. Holst, V. Lohweg, B. Frahm, U. Müller, Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie, 2024."},"title":"Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie","status":"public","conference":{"location":"Lemgo","name":"10. GDL Kongress Lebensmitteltechnologie 2024","start_date":"2024-10-10","end_date":"2024-10-12"},"department":[{"_id":"DEP4028"},{"_id":"DEP5023"},{"_id":"DEP4000"},{"_id":"DEP1308"}],"author":[{"last_name":"Segermann","id":"81965","full_name":"Segermann, Jan","first_name":"Jan"},{"full_name":"Luttmann, Mario","id":"63215","first_name":"Mario","last_name":"Luttmann"},{"first_name":"André","full_name":"Blome, André","id":"62117","last_name":"Blome"},{"first_name":"Sebastian","last_name":"Feldt","full_name":"Feldt, Sebastian","id":"61469"},{"first_name":"Sujee","full_name":"Sivanesan, Sujee","last_name":"Sivanesan"},{"first_name":"Christoph-Alexander","last_name":"Holst","id":"64782","full_name":"Holst, Christoph-Alexander"},{"orcid":"0000-0002-3325-7887","first_name":"Volker","id":"1804","full_name":"Lohweg, Volker","last_name":"Lohweg"},{"id":"45666","last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn"},{"first_name":"Ulrich","last_name":"Müller","full_name":"Müller, Ulrich","id":"12119"}],"year":"2024"},{"publication_status":"published","citation":{"van":"Luttmann M, Blome A, Segermann J, Jekle M, Frahm B, Müller U. 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GDL Kongress Lebensmitteltechnologie 2024, Lemgo.","chicago":"Luttmann, Mario, André Blome, Jan Segermann, Mario Jekle, Björn Frahm, and Ulrich Müller. Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen, 2024.","short":"M. Luttmann, A. Blome, J. Segermann, M. Jekle, B. Frahm, U. Müller, Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen, 2024.","chicago-de":"Luttmann, Mario, André Blome, Jan Segermann, Mario Jekle, Björn Frahm und Ulrich Müller. 2024. Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen.","din1505-2-1":"Luttmann, Mario ; Blome, André ; Segermann, Jan ; Jekle, Mario ; Frahm, Björn ; Müller, Ulrich: Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen, 2024","ama":"Luttmann M, Blome A, Segermann J, Jekle M, Frahm B, Müller U. 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Reinhardt et al., Mycelium-based materials from residues of the regional wood industry.","ama":"Reinhardt L, Gassenmeier V, Feldt S, et al. Mycelium-Based Materials from Residues of the Regional Wood Industry.","chicago-de":"Reinhardt, Lena, Veronika Gassenmeier, Sebastian Feldt, Sebastian Plate, Martin Tremmel, Björn Frahm und Martin Stosch. Mycelium-based materials from residues of the regional wood industry.","din1505-2-1":"Reinhardt, Lena ; Gassenmeier, Veronika ; Feldt, Sebastian ; Plate, Sebastian ; Tremmel, Martin ; Frahm, Björn ; Stosch, Martin: Mycelium-based materials from residues of the regional wood industry","short":"L. Reinhardt, V. Gassenmeier, S. Feldt, S. Plate, M. Tremmel, B. Frahm, M. Stosch, Mycelium-Based Materials from Residues of the Regional Wood Industry, n.d.","chicago":"Reinhardt, Lena, Veronika Gassenmeier, Sebastian Feldt, Sebastian Plate, Martin Tremmel, Björn Frahm, and Martin Stosch. 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Mycelium-based materials from residues of the regional wood industry."},"publication_status":"accepted","language":[{"iso":"eng"}],"_id":"10957","type":"conference_poster","date_created":"2024-01-18T13:25:19Z","user_id":"45666","date_updated":"2025-01-29T13:43:12Z"},{"status":"public","department":[{"_id":"DEP4000"}],"conference":{"start_date":"2024-10-10","end_date":"2024-10-12","location":"Lemgo","name":"10. GDL Kongress Lebensmitteltechnologie"},"year":"2024","author":[{"full_name":"Müller, Carolin","first_name":"Carolin","last_name":"Müller","id":"67085"},{"first_name":"Jarmo","last_name":"Alarinta","full_name":"Alarinta, Jarmo"},{"id":"45666","last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn"},{"full_name":"Wirtanen, Gun","first_name":"Gun","last_name":"Wirtanen"}],"publication_status":"published","citation":{"ama":"Müller C, Alarinta J, Frahm B, Wirtanen G. Investigation of Microbial Spoilage in Vegan Foods.; 2024.","ieee":"C. Müller, J. Alarinta, B. 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Wirtanen, Investigation of Microbial Spoilage in Vegan Foods, 2024.","din1505-2-1":"Müller, Carolin ; Alarinta, Jarmo ; Frahm, Björn ; Wirtanen, Gun: Investigation of microbial spoilage in vegan foods, 2024","chicago-de":"Müller, Carolin, Jarmo Alarinta, Björn Frahm und Gun Wirtanen. 2024. Investigation of microbial spoilage in vegan foods."},"title":"Investigation of microbial spoilage in vegan foods","_id":"12395","language":[{"iso":"eng"}],"date_updated":"2025-01-30T10:40:47Z","user_id":"83781","type":"conference_poster","date_created":"2025-01-29T13:29:42Z"},{"publication_status":"published","citation":{"ufg":"Gassenmeier, Veronika/Campolongo, Giovanni/Frahm, Björn: Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-situ Monitoring of Hybridoma Cell Culture, o. O. 2024.","havard":"V. Gassenmeier, G. Campolongo, B. 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Process Optimization in Baked Goods Production Using Inline Sensors and Objective Product Evaluation.; 2024.","ufg":"Blome, André u. a.: Process optimization in baked goods production using inline sensors and objective product evaluation, o. O. 2024.","bjps":"Blome A et al. (2024) Process Optimization in Baked Goods Production Using Inline Sensors and Objective Product Evaluation. .","havard":"A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process optimization in baked goods production using inline sensors and objective product evaluation, 2024.","mla":"Blome, André, et al. Process Optimization in Baked Goods Production Using Inline Sensors and Objective Product Evaluation. 2024.","apa":"Blome, A., Luttmann, M., Segermann, J., Jekle, M., Frahm, B., & Müller, U. (2024). Process optimization in baked goods production using inline sensors and objective product evaluation. BioProcessingDays 2024, Recklinghausen, Germany.","ieee":"A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, and U. Müller, Process optimization in baked goods production using inline sensors and objective product evaluation. 2024.","chicago":"Blome, André, Mario Luttmann, Jan Segermann, Mario Jekle, Björn Frahm, and Ulrich Müller. Process Optimization in Baked Goods Production Using Inline Sensors and Objective Product Evaluation, 2024."},"publication_status":"published","author":[{"first_name":"André","last_name":"Blome","full_name":"Blome, André","id":"62117"},{"first_name":"Mario","last_name":"Luttmann","id":"63215","full_name":"Luttmann, Mario"},{"first_name":"Jan","id":"81965","last_name":"Segermann","full_name":"Segermann, Jan"},{"first_name":"Mario","last_name":"Jekle","full_name":"Jekle, Mario"},{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"},{"id":"12119","full_name":"Müller, Ulrich","last_name":"Müller","first_name":"Ulrich"}],"year":"2024","conference":{"name":"BioProcessingDays 2024","location":"Recklinghausen, Germany","end_date":"2024-02-28","start_date":"2024-02-26"},"department":[{"_id":"DEP4000"},{"_id":"DEP4028"},{"_id":"DEP5023"},{"_id":"DEP1308"}],"status":"public","type":"conference_poster","date_created":"2025-01-29T13:39:58Z","user_id":"81304","date_updated":"2025-10-17T18:21:38Z","language":[{"iso":"eng"}],"_id":"12397"},{"_id":"12400","doi":"10.1101/2024.05.30.596619","language":[{"iso":"eng"}],"oa":"1","user_id":"83781","date_updated":"2025-07-29T13:23:30Z","date_created":"2025-01-29T13:48:31Z","type":"preprint","publisher":"bioRxiv","status":"public","abstract":[{"lang":"eng","text":"Determining cell density and cell viability is fundamental for any cell cultivation process. In addition to the manual counting method using hemocytometers, (semi-)automated methods offer advantages such as lower variability and shortened analysis times. However, these methods should provide at least comparable results to the manual method, which is why a comparison of methods is essential. We conducted a dilution series experimental design according to ISO 20391-2:2019 and compared two cell counting methods based on validation parameters aligned with the ICH Q2(R1) guideline. Regarding specificity and linearity, the manual (hemocytometer) and semi-automated (Countstar BioTech®) method exhibited similar results in the two evaluated characteristics total cell density and cell viability of CHO-K1 cells. Regarding repeatability of determining total cell density, the semi-automated method achieved significant (α = 0.05) better results with average relative standard deviations of < 6 %, than the manual method with average relative standard deviations of > 9 %. Concerning repeatability of the cell viability measurement, no significant difference between the two methods were shown. These results show the suitabililty of the dilution series experimental design. For the applied example, they indicate that the investigated semi-automated method is an appropriate alternative to the manual method."}],"author":[{"orcid":"https://orcid.org/0000-0002-0502-8032","full_name":"Ramm, Selina","id":"68713","first_name":"Selina","last_name":"Ramm"},{"first_name":"Ulrich","full_name":"Odefey, Ulrich","id":"74218","last_name":"Odefey"},{"id":"45666","first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn"},{"last_name":"Pein-Hackelbusch","full_name":"Pein-Hackelbusch, Miriam","id":"64952","first_name":"Miriam","orcid":"0000-0002-7920-0595"}],"main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2024.05.30.596619v1"}],"year":"2024","department":[{"_id":"DEP4000"},{"_id":"DEP4028"},{"_id":"DEP4014"}],"citation":{"ieee":"S. Ramm, U. Odefey, B. Frahm, and M. Pein-Hackelbusch, “Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters.” bioRxiv, 2024. doi: 10.1101/2024.05.30.596619.","ama":"Ramm S, Odefey U, Frahm B, Pein-Hackelbusch M. Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters. Published online 2024. doi:10.1101/2024.05.30.596619","short":"S. Ramm, U. Odefey, B. Frahm, M. Pein-Hackelbusch, (2024).","din1505-2-1":"Ramm, Selina ; Odefey, Ulrich ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters, bioRxiv (2024)","chicago-de":"Ramm, Selina, Ulrich Odefey, Björn Frahm und Miriam Pein-Hackelbusch. 2024. Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters. bioRxiv. doi:10.1101/2024.05.30.596619, .","apa":"Ramm, S., Odefey, U., Frahm, B., & Pein-Hackelbusch, M. (2024). Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters. bioRxiv. https://doi.org/10.1101/2024.05.30.596619","chicago":"Ramm, Selina, Ulrich Odefey, Björn Frahm, and Miriam Pein-Hackelbusch. “Semi-Automated vs. Manual: Comparative Study of Cell Culture Counting Methods Using Validation Parameters.” bioRxiv, 2024. https://doi.org/10.1101/2024.05.30.596619.","van":"Ramm S, Odefey U, Frahm B, Pein-Hackelbusch M. Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters. bioRxiv; 2024.","havard":"S. Ramm, U. Odefey, B. Frahm, M. Pein-Hackelbusch, Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters, (2024).","mla":"Ramm, Selina, et al. Semi-Automated vs. Manual: Comparative Study of Cell Culture Counting Methods Using Validation Parameters. bioRxiv, 2024, https://doi.org/10.1101/2024.05.30.596619.","bjps":"Ramm S et al. (2024) Semi-Automated vs. Manual: Comparative Study of Cell Culture Counting Methods Using Validation Parameters.","ufg":"Ramm, Selina u. a.: Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters, o. O. 2024."},"publication_status":"published","title":"Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters"},{"keyword":["Anaerobic Digestion Model No. 1 (ADM1)","Anaerobic technology","pH simulation","Uncertainty assessment","Visual Water"],"language":[{"iso":"eng"}],"date_updated":"2025-06-25T12:42:09Z","publication":"Chemie Ingenieur Technik","publication_identifier":{"eissn":["1522-2640"],"issn":["0009-286X"]},"date_created":"2025-01-29T13:49:16Z","status":"public","page":"528-534","year":"2024","author":[{"last_name":"Kosse","full_name":"Kosse, Pascal","first_name":"Pascal"},{"first_name":"Tanja","last_name":"Hernández Rodriguez","id":"52466","full_name":"Hernández Rodriguez, Tanja"},{"id":"45666","last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn"},{"first_name":"Manfred","last_name":"Lübken","full_name":"Lübken, Manfred"},{"full_name":"Wichern, Marc","first_name":"Marc","last_name":"Wichern"}],"external_id":{"isi":["001169606600001"]},"citation":{"ama":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik. 2024;96(4):528-534. doi:10.1002/cite.202300188","ieee":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, and M. Wichern, “Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator,” Chemie Ingenieur Technik, vol. 96, no. 4, pp. 528–534, 2024, doi: 10.1002/cite.202300188.","ufg":"Kosse, Pascal u. a.: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, in: Chemie Ingenieur Technik 96 (2024), H. 4, S. 528–534.","bjps":"Kosse P et al. (2024) Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik 96, 528–534.","mla":"Kosse, Pascal, et al. “Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.” Chemie Ingenieur Technik, vol. 96, no. 4, 2024, pp. 528–34, https://doi.org/10.1002/cite.202300188.","havard":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, Chemie Ingenieur Technik. 96 (2024) 528–534.","van":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik. 2024;96(4):528–34.","chicago":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken, and Marc Wichern. “Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.” Chemie Ingenieur Technik 96, no. 4 (2024): 528–34. https://doi.org/10.1002/cite.202300188.","apa":"Kosse, P., Hernández Rodriguez, T., Frahm, B., Lübken, M., & Wichern, M. (2024). Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik, 96(4), 528–534. https://doi.org/10.1002/cite.202300188","din1505-2-1":"Kosse, Pascal ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Lübken, Manfred ; Wichern, Marc: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. In: Chemie Ingenieur Technik Bd. 96. Weinheim, Wiley (2024), Nr. 4, S. 528–534","chicago-de":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken und Marc Wichern. 2024. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik 96, Nr. 4: 528–534. doi:10.1002/cite.202300188, .","short":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 96 (2024) 528–534."},"volume":96,"title":"Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator","place":"Weinheim","_id":"12402","doi":"10.1002/cite.202300188","user_id":"83781","intvolume":" 96","type":"scientific_journal_article","publisher":"Wiley","quality_controlled":"1","department":[{"_id":"DEP4000"}],"issue":"4","abstract":[{"lang":"eng","text":"In anaerobic technology, pH values are crucial for targeted volatile fatty acid production. While pH dynamics can be modeled using the Anaerobic Digestion Model No. 1 (ADM1), simulation results may be biased. To address this issue, the pH prediction routine of Visual Water, a specialized water chemistry simulator, was validated. Unlike ADM1, it accounts for ionic strength and activities while also providing an automated uncertainty analysis. The analysis revealed Visual Water simulations to better fit measured pH data from acidic solutions in a miniaturized stirred-tank reactor."}],"publication_status":"published","isi":"1"},{"title":"Real-time Monitoring of DCO2 in addition to DO","publication_status":"accepted","citation":{"short":"V. Gassenmeier, G. Campolongo, B. Frahm, Real-Time Monitoring of DCO2 in Addition to DO, n.d.","din1505-2-1":"Gassenmeier, Veronika ; Campolongo, Giovanni ; Frahm, Björn: Real-time Monitoring of DCO2 in addition to DO","chicago-de":"Gassenmeier, Veronika, Giovanni Campolongo und Björn Frahm. Real-time Monitoring of DCO2 in addition to DO.","van":"Gassenmeier V, Campolongo G, Frahm B. Real-time Monitoring of DCO2 in addition to DO.","ufg":"Gassenmeier, Veronika/Campolongo, Giovanni/Frahm, Björn: Real-time Monitoring of DCO2 in addition to DO, o. O. u. J. .","bjps":"Gassenmeier V, Campolongo G and Frahm B (n.d.) Real-Time Monitoring of DCO2 in Addition to DO. .","havard":"V. Gassenmeier, G. Campolongo, B. Frahm, Real-time Monitoring of DCO2 in addition to DO, n.d.","mla":"Gassenmeier, Veronika, et al. Real-Time Monitoring of DCO2 in Addition to DO.","apa":"Gassenmeier, V., Campolongo, G., & Frahm, B. (n.d.). Real-time Monitoring of DCO2 in addition to DO. 8th Bioproduction Congress: Accelerating Biopharma Development for Patients, Lyon, France.","chicago":"Gassenmeier, Veronika, Giovanni Campolongo, and Björn Frahm. Real-Time Monitoring of DCO2 in Addition to DO, n.d.","ama":"Gassenmeier V, Campolongo G, Frahm B. Real-Time Monitoring of DCO2 in Addition to DO.","ieee":"V. Gassenmeier, G. Campolongo, and B. Frahm, Real-time Monitoring of DCO2 in addition to DO."},"department":[{"_id":"DEP4000"}],"conference":{"location":"Lyon, France","name":"8th Bioproduction Congress: Accelerating Biopharma Development for Patients","start_date":"2023-10-05","end_date":"2023-10-06"},"year":"2023","author":[{"full_name":"Gassenmeier, Veronika","id":"74048","first_name":"Veronika","last_name":"Gassenmeier"},{"last_name":"Campolongo","first_name":"Giovanni","full_name":"Campolongo, Giovanni"},{"full_name":"Frahm, Björn","first_name":"Björn","id":"45666","last_name":"Frahm"}],"status":"public","date_created":"2024-04-25T16:21:22Z","type":"conference_poster","date_updated":"2024-05-21T09:23:27Z","user_id":"83781","language":[{"iso":"eng"}],"_id":"11378"},{"publication_status":"accepted","citation":{"chicago":"Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann, and Björn Frahm. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V., n.d.","apa":"Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (n.d.). A systematic, model-based workflow for risk-based decision making in upstream development. 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Berlin, Germany. DECHEMA e.V.","mla":"Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V.","havard":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, DECHEMA e.V., n.d.","bjps":"Hernández Rodriguez T et al. (n.d.) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V.","ufg":"Hernández Rodriguez, Tanja u. a.: A systematic, model-based workflow for risk-based decision making in upstream development, o. O. u. J. .","van":"Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development. DECHEMA e.V.;","chicago-de":"Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann und Björn Frahm. A systematic, model-based workflow for risk-based decision making in upstream development. DECHEMA e.V.","din1505-2-1":"Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development : DECHEMA e.V.","short":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, DECHEMA e.V., n.d.","ieee":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, and B. 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DECHEMA e.V."},"title":"A systematic, model-based workflow for risk-based decision making in upstream development","status":"public","publisher":"DECHEMA e.V.","department":[{"_id":"DEP4000"}],"conference":{"name":"14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology","location":"Berlin, Germany","end_date":"2023-09-21","start_date":"2023-09-17"},"year":"2023","author":[{"id":"52466","first_name":"Tanja","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja"},{"full_name":"Ramm, Selina","id":"68713","last_name":"Ramm","first_name":"Selina","orcid":"https://orcid.org/0000-0002-0502-8032"},{"last_name":"Lange-Hegermann","full_name":"Lange-Hegermann, Markus","id":"71761","first_name":"Markus"},{"full_name":"Frahm, Björn","first_name":"Björn","id":"45666","last_name":"Frahm"}],"date_updated":"2024-08-02T13:57:27Z","user_id":"83781","date_created":"2024-04-26T06:18:20Z","type":"conference_poster","language":[{"iso":"eng"}],"_id":"11381"},{"language":[{"iso":"eng"}],"_id":"11382","oa":"1","user_id":"45666","date_updated":"2025-01-29T13:42:42Z","type":"conference_poster","date_created":"2024-04-26T06:22:50Z","status":"public","author":[{"full_name":"Gassenmeier, Veronika","first_name":"Veronika","last_name":"Gassenmeier","id":"74048"},{"last_name":"Kuhfuß","first_name":"Fabian","full_name":"Kuhfuß, Fabian"},{"last_name":"Deppe","first_name":"Sahar","full_name":"Deppe, Sahar"},{"last_name":"Ifrim","first_name":"George","full_name":"Ifrim, George"},{"id":"52466","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja"},{"full_name":"Frahm, Björn","id":"45666","first_name":"Björn","last_name":"Frahm"}],"main_file_link":[{"open_access":"1","url":"http://www.apz-rl.de/BioProcessingDays_2023/002_download/BPDs_2023_Tagungsbuch_Titel.pdf"}],"year":"2023","conference":{"start_date":"2023-02-27","end_date":"20203-03-01","location":"Recklinghausen, Germany","name":"BioProcessingDays 2023"},"department":[{"_id":"DEP4000"}],"citation":{"van":"Gassenmeier V, Kuhfuß F, Deppe S, Ifrim G, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in shake flasks.","ufg":"Gassenmeier, Veronika u. a.: View on a mechanistic model of Chlorella vulgaris in shake flasks, o. O. u. J. .","havard":"V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in shake flasks, n.d.","mla":"Gassenmeier, Veronika, et al. View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks.","bjps":"Gassenmeier V et al. (n.d.) View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks. .","apa":"Gassenmeier, V., Kuhfuß, F., Deppe, S., Ifrim, G., Hernández Rodriguez, T., & Frahm, B. (n.d.). View on a mechanistic model of Chlorella vulgaris in shake flasks. BioProcessingDays 2023, Recklinghausen, Germany.","chicago":"Gassenmeier, Veronika, Fabian Kuhfuß, Sahar Deppe, George Ifrim, Tanja Hernández Rodriguez, and Björn Frahm. View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks, n.d.","short":"V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks, n.d.","chicago-de":"Gassenmeier, Veronika, Fabian Kuhfuß, Sahar Deppe, George Ifrim, Tanja Hernández Rodriguez und Björn Frahm. View on a mechanistic model of Chlorella vulgaris in shake flasks.","din1505-2-1":"Gassenmeier, Veronika ; Kuhfuß, Fabian ; Deppe, Sahar ; Ifrim, George ; Hernández Rodriguez, Tanja ; Frahm, Björn: View on a mechanistic model of Chlorella vulgaris in shake flasks","ama":"Gassenmeier V, Kuhfuß F, Deppe S, Ifrim G, Hernández Rodriguez T, Frahm B. View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks.","ieee":"V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, and B. Frahm, View on a mechanistic model of Chlorella vulgaris in shake flasks."},"publication_status":"accepted","title":"View on a mechanistic model of Chlorella vulgaris in shake flasks"},{"conference":{"name":"14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology","location":"Berlin, Germany","end_date":"2023-09-21","start_date":"2023-09-17"},"department":[{"_id":"DEP4000"}],"author":[{"first_name":"Tanja","id":"52466","full_name":"Hernández Rodriguez, Tanja","last_name":"Hernández Rodriguez"},{"full_name":"Posch, Christoph","first_name":"Christoph","last_name":"Posch"},{"full_name":"Pörtner, Ralf","last_name":"Pörtner","first_name":"Ralf"},{"id":"71761","full_name":"Lange-Hegermann, Markus","first_name":"Markus","last_name":"Lange-Hegermann"},{"last_name":"Wurm","full_name":"Wurm, Florian M.","first_name":"Florian M."},{"id":"45666","full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn"}],"year":"2023","publisher":"DECHEMA e.V.","status":"public","title":"Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture","publication_status":"published","citation":{"ama":"Hernández Rodriguez T, Posch C, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V.; 2023.","ieee":"T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F. M. Wurm, and B. Frahm, Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture. DECHEMA e.V., 2023.","chicago-de":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, Markus Lange-Hegermann, Florian M. Wurm und Björn Frahm. 2023. Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture. DECHEMA e.V.","din1505-2-1":"Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Lange-Hegermann, Markus ; Wurm, Florian M. ; Frahm, Björn: Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture : DECHEMA e.V., 2023","short":"T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, DECHEMA e.V., 2023.","bjps":"Hernández Rodriguez T et al. (2023) Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V.","havard":"T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture, DECHEMA e.V., 2023.","mla":"Hernández Rodriguez, Tanja, et al. Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V., 2023.","ufg":"Hernández Rodriguez, Tanja u. a.: Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture, o. O. 2023.","van":"Hernández Rodriguez T, Posch C, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture. DECHEMA e.V.; 2023.","chicago":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, Markus Lange-Hegermann, Florian M. Wurm, and Björn Frahm. Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V., 2023.","apa":"Hernández Rodriguez, T., Posch, C., Pörtner, R., Lange-Hegermann, M., Wurm, F. M., & Frahm, B. (2023). Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture. 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Berlin, Germany. DECHEMA e.V."},"_id":"11383","language":[{"iso":"eng"}],"type":"conference_speech","date_created":"2024-04-26T06:40:20Z","date_updated":"2024-05-21T09:06:45Z","user_id":"83781"},{"title":"Microbial spoilage in vegan foods","citation":{"chicago-de":"Müller, Carolin, Jarmo Alarinta, Björn Frahm und Gun Wirtanen. 2023. Microbial spoilage in vegan foods. Proceedings of the 10th International Congress of Food Technologists, Biotechnologists and Nutritionists: Smart Food for a Healthy Planet and Human Prosperity. Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko.","din1505-2-1":"Müller, Carolin ; Alarinta, Jarmo ; Frahm, Björn ; Wirtanen, Gun: Microbial spoilage in vegan foods : Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023","short":"C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial Spoilage in Vegan Foods, Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023.","chicago":"Müller, Carolin, Jarmo Alarinta, Björn Frahm, and Gun Wirtanen. Microbial Spoilage in Vegan Foods. Proceedings of the 10th International Congress of Food Technologists, Biotechnologists and Nutritionists: Smart Food for a Healthy Planet and Human Prosperity. Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023.","ieee":"C. Müller, J. Alarinta, B. Frahm, and G. Wirtanen, Microbial spoilage in vegan foods. Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023, pp. 64–67.","apa":"Müller, C., Alarinta, J., Frahm, B., & Wirtanen, G. (2023). Microbial spoilage in vegan foods. In Proceedings of the 10th International Congress of Food Technologists, Biotechnologists and Nutritionists: Smart Food for a Healthy Planet and Human Prosperity (pp. 64–67). Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko.","havard":"C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial spoilage in vegan foods, Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023.","mla":"Müller, Carolin, et al. “Microbial Spoilage in Vegan Foods.” Proceedings of the 10th International Congress of Food Technologists, Biotechnologists and Nutritionists: Smart Food for a Healthy Planet and Human Prosperity, Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023, pp. 64–67.","bjps":"Müller C et al. (2023) Microbial Spoilage in Vegan Foods. Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko.","ufg":"Müller, Carolin u. a.: Microbial spoilage in vegan foods, o. O. 2023.","ama":"Müller C, Alarinta J, Frahm B, Wirtanen G. Microbial Spoilage in Vegan Foods. Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko; 2023:64-67.","van":"Müller C, Alarinta J, Frahm B, Wirtanen G. Microbial spoilage in vegan foods. Proceedings of the 10th International Congress of Food Technologists, Biotechnologists and Nutritionists: Smart Food for a Healthy Planet and Human Prosperity. Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko; 2023."},"publication_status":"published","main_file_link":[{"open_access":"1","url":"https://pbn2022congress.pbf.hr/wp-content/uploads/2023/03/Proceedings-PBN_2022.pdf"}],"year":"2023","author":[{"last_name":"Müller","full_name":"Müller, Carolin","id":"67085","first_name":"Carolin"},{"full_name":"Alarinta, Jarmo","last_name":"Alarinta","first_name":"Jarmo"},{"full_name":"Frahm, Björn","first_name":"Björn","id":"45666","last_name":"Frahm"},{"full_name":"Wirtanen, Gun","last_name":"Wirtanen","first_name":"Gun"}],"department":[{"_id":"DEP4000"}],"conference":{"name":"10th International Congress of Food Technologists, Biotechnologists and Nutritionists","location":"Zagreb","start_date":"2022-11-30","end_date":"2022-12-02"},"status":"public","page":"64 – 67","publisher":"Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko","publication":"Proceedings of the 10th International Congress of Food Technologists, Biotechnologists and Nutritionists: Smart Food for a Healthy Planet and Human Prosperity","publication_identifier":{"issn":["2975-7118"]},"type":"conference_editor_article","date_created":"2024-04-26T06:43:46Z","user_id":"83781","date_updated":"2024-05-21T07:27:00Z","oa":"1","language":[{"iso":"eng"}],"_id":"11384"},{"isi":"1","publication_status":"published","abstract":[{"text":"Accurate pH calculations are essential for scientists across different disciplines to design optimal reactor solutions, but they can be arduous to calculate for complex acid-base solutions. Visual Water is a powerful software tool that provides accurate pH calculations with automated mathematical uncertainty analysis. Its workflow is presented and validated using acids and bases, showing a deviation of < 0.2 pH units between measured and calculated pH values. This highlights the software's reliability, which can help to simplify the work of non-experts in water chemistry.","lang":"eng"}],"issue":"12","department":[{"_id":"DEP4000"}],"publisher":"Wiley","quality_controlled":"1","type":"scientific_journal_article","intvolume":" 95","user_id":"83781","_id":"11385","doi":"10.1002/cite.202300082","place":"Weinheim","title":"Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations","volume":95,"citation":{"ama":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik. 2023;95(12):1960-1969. doi:10.1002/cite.202300082","ieee":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, and M. Wichern, “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations,” Chemie Ingenieur Technik, vol. 95, no. 12, pp. 1960–1969, 2023, doi: 10.1002/cite.202300082.","ufg":"Kosse, Pascal u. a.: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, in: Chemie Ingenieur Technik 95 (2023), H. 12, S. 1960–1969.","havard":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, Chemie Ingenieur Technik. 95 (2023) 1960–1969.","mla":"Kosse, Pascal, et al. “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations.” Chemie Ingenieur Technik, vol. 95, no. 12, 2023, pp. 1960–69, https://doi.org/10.1002/cite.202300082.","bjps":"Kosse P et al. (2023) Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations. Chemie Ingenieur Technik 95, 1960–1969.","van":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik. 2023;95(12):1960–9.","chicago":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken, and Marc Wichern. “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations.” Chemie Ingenieur Technik 95, no. 12 (2023): 1960–69. https://doi.org/10.1002/cite.202300082.","apa":"Kosse, P., Hernández Rodriguez, T., Frahm, B., Lübken, M., & Wichern, M. (2023). Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik, 95(12), 1960–1969. https://doi.org/10.1002/cite.202300082","din1505-2-1":"Kosse, Pascal ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Lübken, Manfred ; Wichern, Marc: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. In: Chemie Ingenieur Technik Bd. 95. Weinheim, Wiley (2023), Nr. 12, S. 1960–1969","chicago-de":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken und Marc Wichern. 2023. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik 95, Nr. 12: 1960–1969. doi:10.1002/cite.202300082, .","short":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 95 (2023) 1960–1969."},"external_id":{"isi":["001073579300001"]},"author":[{"full_name":"Kosse, Pascal","last_name":"Kosse","first_name":"Pascal"},{"last_name":"Hernández Rodriguez","first_name":"Tanja","id":"52466","full_name":"Hernández Rodriguez, Tanja"},{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"first_name":"Manfred","full_name":"Lübken, Manfred","last_name":"Lübken"},{"full_name":"Wichern, Marc","last_name":"Wichern","first_name":"Marc"}],"year":"2023","status":"public","page":"1960-1969","publication":"Chemie Ingenieur Technik","publication_identifier":{"eissn":["1522-2640"],"issn":["0009-286X"]},"date_created":"2024-04-26T06:52:48Z","date_updated":"2025-06-26T07:50:29Z","keyword":["Acid-base equilibria","Carboxylic acids","Dissociation constants","pH calculation software","Uncertainty assessment"],"language":[{"iso":"eng"}]},{"language":[{"iso":"eng"}],"_id":"11487","oa":"1","date_updated":"2024-05-21T09:37:15Z","user_id":"83781","type":"conference_poster","date_created":"2024-05-21T09:37:09Z","status":"public","publisher":"DECHEMA e.V.","conference":{"start_date":"2023-09-17","end_date":"2023-09-21","location":"Berlin, Germany","name":"14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology"},"department":[{"_id":"DEP4000"}],"year":"2023","main_file_link":[{"url":"http://www.apz-rl.de/BioProcessingDays_2023/002_download/BPDs_2023_Tagungsbuch_Titel.pdf","open_access":"1"}],"author":[{"orcid":"https://orcid.org/0000-0002-0502-8032","last_name":"Ramm","full_name":"Ramm, Selina","id":"68713","first_name":"Selina"},{"first_name":"Tanja","last_name":"Hernández Rodriguez","id":"52466","full_name":"Hernández Rodriguez, Tanja"},{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"},{"last_name":"Pein-Hackelbusch","id":"64952","full_name":"Pein-Hackelbusch, Miriam","first_name":"Miriam","orcid":"0000-0002-7920-0595"}],"publication_status":"accepted","citation":{"chicago":"Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm, and Miriam Pein-Hackelbusch. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V., n.d.","apa":"Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (n.d.). Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Berlin, Germany. DECHEMA e.V.","ieee":"S. Ramm, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.","ufg":"Ramm, Selina u. a.: Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression , o. O. u. J. .","havard":"S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression , DECHEMA e.V., n.d.","bjps":"Ramm S et al. (n.d.) Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.","mla":"Ramm, Selina, et al. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.","van":"Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.;","ama":"Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.","chicago-de":"Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.","din1505-2-1":"Ramm, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression : DECHEMA e.V.","short":"S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression , DECHEMA e.V., n.d."},"title":"Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression "},{"language":[{"iso":"eng"}],"_id":"13650","date_created":"2026-03-27T16:43:01Z","type":"conference_speech","user_id":"45666","date_updated":"2026-03-27T16:44:47Z","year":"2023","author":[{"id":"68713","first_name":"Selina","full_name":"Uhlendorff, Selina","last_name":"Uhlendorff","orcid":"https://orcid.org/0000-0002-0502-8032"},{"full_name":"Hernández Rodríguez, Tanja","first_name":"Tanja","last_name":"Hernández Rodríguez"},{"id":"45666","full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn"},{"orcid":"0000-0002-7920-0595","last_name":"Pein-Hackelbusch","first_name":"Miriam","full_name":"Pein-Hackelbusch, Miriam","id":"64952"}],"conference":{"start_date":"17.7.2023","end_date":"20.7.2023","name":"IEEE International Conference on Industrial Informatics, INDIN ’23","location":"Lemgo, Germany"},"department":[{"_id":"DEP4000"}],"status":"public","title":"Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities","citation":{"chicago":"Uhlendorff, Selina, Tanja Hernández Rodríguez, Björn Frahm, and Miriam Pein-Hackelbusch. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023.","apa":"Uhlendorff, S., Hernández Rodríguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. IEEE International Conference on Industrial Informatics, INDIN ’23, Lemgo, Germany.","havard":"S. Uhlendorff, T. Hernández Rodríguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023.","mla":"Uhlendorff, Selina, et al. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. 2023.","bjps":"Uhlendorff S et al. (2023) Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. .","ufg":"Uhlendorff, Selina u. a.: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, o. O. 2023.","van":"Uhlendorff S, Hernández Rodríguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. 2023.","din1505-2-1":"Uhlendorff, Selina ; Hernández Rodríguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023","chicago-de":"Uhlendorff, Selina, Tanja Hernández Rodríguez, Björn Frahm und Miriam Pein-Hackelbusch. 2023. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities.","short":"S. Uhlendorff, T. Hernández Rodríguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023.","ieee":"S. Uhlendorff, T. Hernández Rodríguez, B. Frahm, and M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. 2023.","ama":"Uhlendorff S, Hernández Rodríguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities.; 2023."}},{"status":"public","department":[{"_id":"DEP4000"}],"conference":{"end_date":"2023-03-01","start_date":"2023-02-27","location":"Recklinghausen, Germany","name":"BioProcessingDays 2023"},"main_file_link":[{"open_access":"1","url":"http://www.apz-rl.de/BioProcessingDays_2023/002_download/BPDs_2023_Tagungsbuch_Titel.pdf"}],"author":[{"first_name":"Tanja","id":"52466","full_name":"Hernández Rodriguez, Tanja","last_name":"Hernández Rodriguez"},{"orcid":"https://orcid.org/0000-0002-0502-8032","first_name":"Selina","full_name":"Ramm, Selina","last_name":"Ramm","id":"68713"},{"full_name":"Lange-Hegermann, Markus","id":"71761","last_name":"Lange-Hegermann","first_name":"Markus"},{"id":"45666","full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn"}],"year":"2023","publication_status":"published","citation":{"ama":"Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development.; 2023.","ieee":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, and B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development. 2023.","din1505-2-1":"Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development, 2023","chicago-de":"Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann und Björn Frahm. 2023. A systematic, model-based workflow for risk-based decision making in upstream development.","short":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, 2023.","bjps":"Hernández Rodriguez T et al. (2023) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. .","havard":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, 2023.","mla":"Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. 2023.","ufg":"Hernández Rodriguez, Tanja u. a.: A systematic, model-based workflow for risk-based decision making in upstream development, o. O. 2023.","van":"Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development. 2023.","chicago":"Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann, and Björn Frahm. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, 2023.","apa":"Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (2023). A systematic, model-based workflow for risk-based decision making in upstream development. BioProcessingDays 2023, Recklinghausen, Germany."},"title":"A systematic, model-based workflow for risk-based decision making in upstream development","_id":"10201","language":[{"iso":"eng"}],"oa":"1","date_updated":"2024-08-02T09:41:01Z","user_id":"83781","date_created":"2023-08-08T14:54:44Z","type":"conference_poster"},{"department":[{"_id":"DEP4022"},{"_id":"DEP4028"}],"conference":{"location":"Lemgo","name":"21st International Conference on Industrial Informatics (INDIN)","start_date":"2023-07-18","end_date":"2023-07-20"},"abstract":[{"lang":"eng","text":"For process monitoring, an adequate data preprocessing is crucial to link accessible inline process data with offline measured target variables. Literature, however, does not provide systematic preprocessing strategies. The effects of five different preprocessing strategies on data from a Dielectric Spectroscopy system applied to the Viable Cell Density (VCD) of a mammalian cell cultivation were thus evaluated. Single-frequency measurements are typically used to model the VCD over the growth phase using linear regression or the Cole-Cole model and served as a reference. As multi-frequency measurement is promising to model the VCD beyond the growth phase using Partial Least Squares Regression (PLSR), we further aimed to determine, whether replacing linear regression by PLSR shows comparable modeling performance. All five preprocessing strategies led to comparable results. Exemplary, when using capacitance values at a frequency of 3347 kHz, linear regression resulted in a R2 of 0.90 and a standard deviation of 0.4 % on average. Both normalization techniques had the same positive effect on the results of PLSR. The order of smoothing and normalization was irrelevant for both regression methods. Comparing the results of linear regression and PLSR, the latter obtained on average 9 % better results. Therefore, we concluded that PLSR is preferable over linear regression and is potentially suitable to model the VCD beyond the growth phase, which is suggested to be investigated based on more data sets."}],"publisher":"IEEE","publication_status":"published","place":"[Piscataway, NJ]","doi":"10.1109/INDIN51400.2023.10218012","_id":"10788","type":"conference_editor_article","user_id":"83781","main_file_link":[{"url":"https://ieeexplore.ieee.org/document/10218012","open_access":"1"}],"author":[{"orcid":"https://orcid.org/0000-0002-0502-8032","first_name":"Selina","last_name":"Ramm","id":"68713","full_name":"Ramm, Selina"},{"first_name":"Tanja","id":"52466","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja"},{"first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm","id":"45666"},{"full_name":"Pein-Hackelbusch, Miriam","first_name":"Miriam","last_name":"Pein-Hackelbusch","id":"64952","orcid":"0000-0002-7920-0595"}],"year":"2023","page":"1-6","status":"public","title":"Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities","citation":{"ama":"Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. (Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , eds.). IEEE; 2023:1-6. doi:10.1109/INDIN51400.2023.10218012","ieee":"S. Ramm, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. [Piscataway, NJ]: IEEE, 2023, pp. 1–6. doi: 10.1109/INDIN51400.2023.10218012.","din1505-2-1":"Ramm, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam ; Jasperneite, J. ; Wisniewski, L. ; Fung Man, K. ; Institute of Electrical and Electronics Engineers (Hrsg.): Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. [Piscataway, NJ] : IEEE, 2023","chicago-de":"Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. 2023. 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The experimental shake flask setting used in this study allows to run 12 experiments at the same time, with 6 individual light intensities and light durations. This way, 54 biomass data sets were generated for the cultivation of the microalgae Chlorella vulgaris. To identify the model parameters, a stepwise parameter estimation procedure was applied. First, light-associated model parameters were estimated using additional measurements of local light intensities at differ heights within medium at different biomass concentrations. Next, substrate related model parameters were estimated, using experiments for which biomass and nitrate data were provided. Afterwards, growth-related model parameters were estimated by application of an extensive cross validation procedure.","lang":"eng"}],"publisher":"Springer","quality_controlled":"1","publication_status":"published","language":[{"iso":"eng"}],"publication_identifier":{"issn":["1615-7591 "],"eissn":["1615-7605"]},"publication":"Bioprocess and Biosystems Engineering","date_created":"2022-05-05T11:28:56Z","date_updated":"2024-08-05T07:07:37Z","year":"2022","author":[{"last_name":"Kuhfuß","full_name":"Kuhfuß, Fabian","first_name":"Fabian"},{"id":"74048","last_name":"Gassenmeier","first_name":"Veronika","full_name":"Gassenmeier, Veronika"},{"last_name":"Deppe","first_name":"Sahar","id":"52121","full_name":"Deppe, Sahar"},{"last_name":"Ifrim","first_name":"George Adrian","full_name":"Ifrim, George Adrian","id":"73814"},{"first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja","last_name":"Hernández Rodriguez","id":"52466"},{"first_name":"Björn","id":"45666","full_name":"Frahm, Björn","last_name":"Frahm"}],"status":"public","page":"15-30","title":"View on a mechanistic model of Chlorella vulgaris in incubated shake flasks","citation":{"short":"F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, Bioprocess and Biosystems Engineering 45 (2022) 15–30.","chicago-de":"Kuhfuß, Fabian, Veronika Gassenmeier, Sahar Deppe, George Adrian Ifrim, Tanja Hernández Rodriguez und Björn Frahm. 2022. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering 45: 15–30. doi:10.1007/s00449-021-02627-2, .","din1505-2-1":"Kuhfuß, Fabian ; Gassenmeier, Veronika ; Deppe, Sahar ; Ifrim, George Adrian ; Hernández Rodriguez, Tanja ; Frahm, Björn: View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. In: Bioprocess and Biosystems Engineering Bd. 45. Berlin, Springer (2022), S. 15–30","van":"Kuhfuß F, Gassenmeier V, Deppe S, Ifrim GA, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering. 2022;45:15–30.","havard":"F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in incubated shake flasks, Bioprocess and Biosystems Engineering. 45 (2022) 15–30.","mla":"Kuhfuß, Fabian, et al. “View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks.” Bioprocess and Biosystems Engineering, vol. 45, 2022, pp. 15–30, https://doi.org/10.1007/s00449-021-02627-2.","bjps":"Kuhfuß F et al. (2022) View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks. Bioprocess and Biosystems Engineering 45, 15–30.","ufg":"Kuhfuß, Fabian u. a.: View on a mechanistic model of Chlorella vulgaris in incubated shake flasks, in: Bioprocess and Biosystems Engineering 45 (2022), S. 15–30.","apa":"Kuhfuß, F., Gassenmeier, V., Deppe, S., Ifrim, G. A., Hernández Rodriguez, T., & Frahm, B. (2022). View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering, 45, 15–30. https://doi.org/10.1007/s00449-021-02627-2","chicago":"Kuhfuß, Fabian, Veronika Gassenmeier, Sahar Deppe, George Adrian Ifrim, Tanja Hernández Rodriguez, and Björn Frahm. “View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks.” Bioprocess and Biosystems Engineering 45 (2022): 15–30. https://doi.org/10.1007/s00449-021-02627-2.","ama":"Kuhfuß F, Gassenmeier V, Deppe S, Ifrim GA, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering. 2022;45:15-30. doi:10.1007/s00449-021-02627-2","ieee":"F. Kuhfuß, V. Gassenmeier, S. Deppe, G. A. Ifrim, T. Hernández Rodriguez, and B. Frahm, “View on a mechanistic model of Chlorella vulgaris in incubated shake flasks,” Bioprocess and Biosystems Engineering, vol. 45, pp. 15–30, 2022, doi: 10.1007/s00449-021-02627-2."},"volume":45},{"status":"public","author":[{"full_name":"Hernández Rodriguez, Tanja","id":"52466","last_name":"Hernández Rodriguez","first_name":"Tanja"},{"full_name":"Sekulic, Anton","last_name":"Sekulic","first_name":"Anton"},{"first_name":"Markus","last_name":"Lange-Hegermann","id":"71761","full_name":"Lange-Hegermann, Markus"},{"full_name":"Frahm, Björn","first_name":"Björn","id":"45666","last_name":"Frahm"}],"year":"2022","citation":{"ama":"Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes. 2022;10(5). doi:10.3390/pr10050883","ieee":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, and B. Frahm, “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design,” Processes, vol. 10, no. 5, Art. no. 883, 2022, doi: 10.3390/pr10050883.","bjps":"Hernández Rodriguez T et al. (2022) Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes 10.","havard":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, Processes. 10 (2022).","mla":"Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Processes, vol. 10, no. 5, 883, 2022, https://doi.org/10.3390/pr10050883.","ufg":"Hernández Rodriguez, Tanja u. a.: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, in: Processes 10 (2022), H. 5.","van":"Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes. 2022;10(5).","chicago":"Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann, and Björn Frahm. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Processes 10, no. 5 (2022). https://doi.org/10.3390/pr10050883.","apa":"Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes, 10(5), Article 883. https://doi.org/10.3390/pr10050883","chicago-de":"Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann und Björn Frahm. 2022. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes 10, Nr. 5. doi:10.3390/pr10050883, .","din1505-2-1":"Hernández Rodriguez, Tanja ; Sekulic, Anton ; Lange-Hegermann, Markus ; Frahm, Björn: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In: Processes Bd. 10. Basel, MDPI AG (2022), Nr. 5","short":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Processes 10 (2022)."},"volume":10,"title":"Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design","keyword":["Gaussian processes","Bayes optimization","Pareto optimization","multi-objective","cell culture","seed train"],"language":[{"iso":"eng"}],"date_updated":"2024-05-21T09:30:15Z","publication":"Processes","publication_identifier":{"eissn":["2227-9717"]},"date_created":"2024-04-25T13:35:04Z","publisher":"MDPI AG","issue":"5","abstract":[{"text":"consuming and often performed rather empirically. Efficient optimization of multiple objectives such as process time, viable cell density, number of operating steps & cultivation scales, required medium, amount of product as well as product quality depicts a promising approach. This contribution presents a workflow which couples uncertainty-based upstream simulation and Bayes optimization using Gaussian processes. Its application is demonstrated in a simulation case study for a relevant industrial task in process development, the design of a robust cell culture expansion process (seed train), meaning that despite uncertainties and variabilities concerning cell growth, low variations of viable cell density during the seed train are obtained. Compared to a non-optimized reference seed train, the optimized process showed much lower deviation rates regarding viable cell densities (<10% instead of 41.7%) using five or four shake flask scales and seed train duration could be reduced by 56 h from 576 h to 520 h. Overall, it is shown that applying Bayes optimization allows for optimization of a multi-objective optimization function with several optimizable input variables and under a considerable amount of constraints with a low computational effort. This approach provides the potential to be used in the form of a decision tool, e.g., for the choice of an optimal and robust seed train design or for further optimization tasks within process development.","lang":"eng"}],"department":[{"_id":"DEP4000"}],"publication_status":"published","_id":"11377","doi":"10.3390/pr10050883","article_number":"883","place":"Basel","intvolume":" 10","user_id":"83781","type":"scientific_journal_article"},{"title":"Real-time Monitoring of DCO2 in addition to DO","citation":{"apa":"Gassenmeier, V., & Frahm, B. (2022). Real-time Monitoring of DCO2 in addition to DO. assets-labs.","ieee":"V. Gassenmeier and B. Frahm, Real-time Monitoring of DCO2 in addition to DO. assets-labs, 2022.","chicago":"Gassenmeier, Veronika, and Björn Frahm. Real-Time Monitoring of DCO2 in Addition to DO. assets-labs, 2022.","van":"Gassenmeier V, Frahm B. Real-time Monitoring of DCO2 in addition to DO. assets-labs; 2022.","ama":"Gassenmeier V, Frahm B. 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Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner R, Möller J, eds. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Vol special issue. Processes : open access journal. MDPI; 2022:21-48. doi:https://doi.org/10.3390/pr10050883","ieee":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, and B. Frahm, “Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design,” in Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue, R. Pörtner and J. Möller, Eds. Basel: MDPI, 2022, pp. 21–48. doi: https://doi.org/10.3390/pr10050883.","chicago-de":"Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann und Björn Frahm. 2022. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, hg. von Ralf Pörtner und Johannes Möller, special issue:21–48. Processes : open access journal. Basel: MDPI. doi:https://doi.org/10.3390/pr10050883, .","din1505-2-1":"Hernández Rodriguez, Tanja ; Sekulic, Anton ; Lange-Hegermann, Markus ; Frahm, Björn: Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner, R. ; Möller, J. (Hrsg.): Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Processes : open access journal. Bd. special issue. Basel : MDPI, 2022, S. 21–48","short":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022, pp. 21–48.","bjps":"Hernández Rodriguez T et al. (2022) Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In Pörtner R and Möller J (eds), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue. Basel: MDPI, pp. 21–48.","mla":"Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, edited by Ralf Pörtner and Johannes Möller, vol. special issue, MDPI, 2022, pp. 21–48, https://doi.org/10.3390/pr10050883.","havard":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. 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Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2022. p. 21–48. (Processes : open access journal; vol. special issue).","chicago":"Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann, and Björn Frahm. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” In Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, edited by Ralf Pörtner and Johannes Möller, special issue:21–48. Processes : Open Access Journal. Basel: MDPI, 2022. https://doi.org/10.3390/pr10050883.","apa":"Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In R. Pörtner & J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue (pp. 21–48). MDPI. https://doi.org/10.3390/pr10050883"},"volume":"special issue","title":"Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design","language":[{"iso":"eng"}],"keyword":["Gaussian processes","Bayes optimization","Pareto optimization","multi-objective","cell culture","seed train"],"date_updated":"2023-08-16T09:24:16Z","editor":[{"last_name":"Pörtner","first_name":"Ralf","full_name":"Pörtner, Ralf"},{"last_name":"Möller","full_name":"Möller, Johannes","first_name":"Johannes"}],"date_created":"2023-08-08T12:58:36Z","publication_identifier":{"eisbn":["978-3-0365-5209-5"],"eissn":["2227-9717"],"isbn":["978-3-0365-5210-1"]},"publication":"Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing","quality_controlled":"1","publisher":"MDPI","department":[{"_id":"DEP4000"}],"abstract":[{"text":"Development and optimization of biopharmaceutical production processes with cell cultures is cost- and time-consuming and often performed rather empirically. Efficient optimization of multiple objectives such as process time, viable cell density, number of operating steps & cultivation scales, required medium, amount of product as well as product quality depicts a promising approach. This contribution presents a workflow which couples uncertainty-based upstream simulation and Bayes optimization using Gaussian processes. Its application is demonstrated in a simulation case study for a relevant industrial task in process development, the design of a robust cell culture expansion process (seed train), meaning that despite uncertainties and variabilities concerning cell growth, low variations of viable cell density during the seed train are obtained. Compared to a non-optimized reference seed train, the optimized process showed much lower deviation rates regarding viable cell densities (<10% instead of 41.7%) using five or four shake flask scales and seed train duration could be reduced by 56 h from 576 h to 520 h. Overall, it is shown that applying Bayes optimization allows for optimization of a multi-objective optimization function with several optimizable input variables and under a considerable amount of constraints with a low computational effort. This approach provides the potential to be used in the form of a decision tool, e.g., for the choice of an optimal and robust seed train design or for further optimization tasks within process development.","lang":"eng"}],"publication_status":"published","series_title":"Processes : open access journal","place":"Basel","doi":"https://doi.org/10.3390/pr10050883","_id":"10193","user_id":"83781","type":"book_chapter"},{"year":"2022","author":[{"last_name":"Blome","first_name":"André","id":"62117","full_name":"Blome, André"},{"full_name":"Luttmann, Mario","id":"63215","first_name":"Mario","last_name":"Luttmann"},{"full_name":"Segermann, Jan","id":"81965","first_name":"Jan","last_name":"Segermann"},{"full_name":"Jekle, Mario","last_name":"Jekle","first_name":"Mario"},{"id":"45666","last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn"},{"last_name":"Müller","first_name":"Ulrich","full_name":"Müller, Ulrich","id":"12119"}],"conference":{"name":"33rd VH Yeast Conference 2022: Advances in Applied Research & Industrial Production of Baker’s Yeast, “100th anniversary of VH Berlin & Yeast(s) as an alternative protein source”","location":"Berlin, Germany","start_date":"2022-09-12","end_date":"2022-09-13"},"department":[{"_id":"DEP4000"},{"_id":"DEP1308"}],"status":"public","page":"61 - 66","publisher":"Versuchsanstalt der Hefeindustrie e.V.","title":"Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products","citation":{"short":"A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products, Versuchsanstalt der Hefeindustrie e.V., 2022.","din1505-2-1":"Blome, André ; Luttmann, Mario ; Segermann, Jan ; Jekle, Mario ; Frahm, Björn ; Müller, Ulrich: Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products : Versuchsanstalt der Hefeindustrie e.V., 2022","chicago-de":"Blome, André, Mario Luttmann, Jan Segermann, Mario Jekle, Björn Frahm und Ulrich Müller. 2022. Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products. Proceedings of the 33rd VH Yeast Conference 2022: Advances in Applied Research & Industrial Production of Baker’s Yeast, “100th anniversary of VH Berlin & Yeast(s) as an alternative protein source”. Versuchsanstalt der Hefeindustrie e.V.","van":"Blome A, Luttmann M, Segermann J, Jekle M, Frahm B, Müller U. Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products. 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Fasse, J. Alarinta, B. Frahm, and G. Wirtanen, “Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing,” Dairy, vol. 2, no. 4, pp. 556–575, 2021, doi: 10.3390/dairy2040044.","ama":"Fasse S, Alarinta J, Frahm B, Wirtanen G. Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy. 2021;2(4):556-575. doi:10.3390/dairy2040044","chicago-de":"Fasse, Sylvia, Jarmo Alarinta, Björn Frahm und Gun Wirtanen. 2021. Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy 2, Nr. 4: 556–575. doi:10.3390/dairy2040044, .","din1505-2-1":"Fasse, Sylvia ; Alarinta, Jarmo ; Frahm, Björn ; Wirtanen, Gun: Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. In: Dairy Bd. 2. Basel, MDPI (2021), Nr. 4, S. 556–575","short":"S. Fasse, J. Alarinta, B. Frahm, G. Wirtanen, Dairy 2 (2021) 556–575.","chicago":"Fasse, Sylvia, Jarmo Alarinta, Björn Frahm, and Gun Wirtanen. “Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing.” Dairy 2, no. 4 (2021): 556–75. https://doi.org/10.3390/dairy2040044.","apa":"Fasse, S., Alarinta, J., Frahm, B., & Wirtanen, G. (2021). Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy, 2(4), 556–575. https://doi.org/10.3390/dairy2040044","ufg":"Fasse, Sylvia u. a.: Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing, in: Dairy 2 (2021), H. 4, S. 556–575.","havard":"S. Fasse, J. Alarinta, B. Frahm, G. Wirtanen, Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing, Dairy. 2 (2021) 556–575.","mla":"Fasse, Sylvia, et al. “Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing.” Dairy, vol. 2, no. 4, 2021, pp. 556–75, https://doi.org/10.3390/dairy2040044.","bjps":"Fasse S et al. (2021) Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy 2, 556–575.","van":"Fasse S, Alarinta J, Frahm B, Wirtanen G. Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy. 2021;2(4):556–75."},"title":"Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing","place":"Basel","_id":"7981","doi":"10.3390/dairy2040044","user_id":"83781","intvolume":" 2","type":"scientific_journal_article","publisher":"MDPI","quality_controlled":"1","department":[{"_id":"DEP4021"}],"abstract":[{"lang":"eng","text":"The main purpose of bovine colostrum, being the milk secreted by a cow after giving birth, is to transfer passive immunity to the calf. The calves have an immature immune system as they lack immunoglobulins (Igs). Subsequently, the supply of good quality bovine colostrum is required. The quality of colostrum is classified by low bacterial counts and adequate Ig concentrations. Bacterial contamination can contain a variety of human pathogens or high counts of spoilage bacteria, which has become more challenging with the emerging use of bovine colostrum as food and food supplements. There is also a growing risk for the spread of zoonotic diseases originating from bovines. For this reason, processing based on heat treatment or other feasible techniques is required. This review provides an overview of literature on the microbial quality of bovine colostrum and processing methods to improve its microbial quality and keep its nutritional values as food. The highlights of this review are as follows: high quality colostrum is a valuable raw material in food products and supplements; the microbial safety of bovine colostrum is increased using an appropriate processing-suitable effective heat treatment which does not destroy the high nutrition value of colostrum; the heat treatment processes are cost-effective compared to other methods; and heat treatment can be performed in both small- and large-scale production."}],"issue":"4","publication_status":"published","isi":"1"},{"page":"49-74","status":"public","author":[{"full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja","id":"52466","last_name":"Hernández Rodriguez"},{"first_name":"Sophie","full_name":"Morerod, Sophie","last_name":"Morerod"},{"full_name":"Pörtner, Ralf","first_name":"Ralf","last_name":"Pörtner"},{"last_name":"Wurm","first_name":"Florian M.","full_name":"Wurm, Florian M."},{"last_name":"Frahm","full_name":"Frahm, Björn","id":"45666","first_name":"Björn"}],"year":"2021","citation":{"chicago-de":"Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm und Björn Frahm. 2021. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, special issue:49–74. Processes : open access journal . Basel: MDPI. doi:10.3390/pr9060964, .","din1505-2-1":"Hernández Rodriguez, Tanja ; Morerod, Sophie ; Pörtner, Ralf ; Wurm, Florian M. ; Frahm, Björn: Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Processes : open access journal . Bd. special issue. Basel : MDPI, 2021, S. 49–74","short":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021, pp. 49–74.","chicago":"Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm, and Björn Frahm. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study.” In Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, special issue:49–74. Processes : Open Access Journal . Basel: MDPI, 2021. https://doi.org/10.3390/pr9060964.","apa":"Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm, B. (2021). Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue (pp. 49–74). MDPI. https://doi.org/10.3390/pr9060964","ieee":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F. M. Wurm, and B. Frahm, “Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study,” in Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue, Basel: MDPI, 2021, pp. 49–74. doi: 10.3390/pr9060964.","ufg":"Hernández Rodriguez, Tanja u. a.: Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: o. Hg.: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Band special issue, Basel 2021 (Processes : open access journal ), S. 49–74.","havard":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021: pp. 49–74.","mla":"Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study.” Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue, MDPI, 2021, pp. 49–74, https://doi.org/10.3390/pr9060964.","bjps":"Hernández Rodriguez T et al. (2021) Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue. Basel: MDPI, pp. 49–74.","van":"Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2021. p. 49–74. (Processes : open access journal ; vol. special issue).","ama":"Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Vol special issue. Processes : open access journal . MDPI; 2021:49-74. doi:10.3390/pr9060964"},"volume":"special issue","title":"Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study","language":[{"iso":"eng"}],"keyword":["clonal cell population","phenotypic diversity","inoculum train","uncertainty-based","cell culture model","biopharmaceutical manufacturing"],"date_updated":"2023-08-16T09:17:50Z","date_created":"2022-05-05T12:55:52Z","publication":"Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing","publication_identifier":{"issn":["2227-9717 "],"eisbn":["978-3-0365-5209-5"],"isbn":["978-3-0365-5210-1"]},"quality_controlled":"1","publisher":"MDPI","abstract":[{"text":"For the manufacturing of complex biopharmaceuticals using bioreactors with cultivated mammalian cells, high product concentration is an important objective. The phenotype of the cells in a reactor plays an important role. Are clonal cell populations showing high cell-specific growth rates more favorable than cell lines with higher cell-specific productivities or vice versa? Five clonal Chinese hamster ovary cell populations were analyzed based on the data of a 3-month-stability study. We adapted a mechanistic cell culture model to the experimental data of one such clonally derived cell population. Uncertainties and prior knowledge concerning model parameters were considered using Bayesian parameter estimations. This model was used then to define an inoculum train protocol. Based on this, we subsequently simulated the impacts of differences in growth rates (±10%) and production rates (±10% and ±50%) on the overall cultivation time, including making the inoculum train cultures; the final production phase, the volumetric titer in that bioreactor and the ratio of both, defined as overall process productivity. We showed thus unequivocally that growth rates have a higher impact (up to three times) on overall process productivity and for product output per year, whereas cells with higher productivity can potentially generate higher product concentrations in the production vessel.","lang":"eng"}],"department":[{"_id":"DEP4021"}],"publication_status":"published","series_title":"Processes : open access journal ","doi":"10.3390/pr9060964","_id":"7983","place":"Basel","user_id":"83781","type":"book_chapter"},{"status":"public","year":"2021","author":[{"full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja","last_name":"Hernández Rodriguez","id":"52466"},{"first_name":"Sophie","last_name":"Morerod","full_name":"Morerod, Sophie"},{"full_name":"Pörtner, Ralf","first_name":"Ralf","last_name":"Pörtner"},{"full_name":"Wurm, Florian M.","first_name":"Florian M.","last_name":"Wurm"},{"full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn","id":"45666"}],"citation":{"ama":"Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes. 2021;9(6). doi:10.3390/pr9060964","ieee":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F. M. Wurm, and B. Frahm, “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study,” Processes, vol. 9, no. 6, Art. no. 964, 2021, doi: 10.3390/pr9060964.","short":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Processes 9 (2021).","din1505-2-1":"Hernández Rodriguez, Tanja ; Morerod, Sophie ; Pörtner, Ralf ; Wurm, Florian M. ; Frahm, Björn: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. In: Processes Bd. 9. Basel, MDPI AG (2021), Nr. 6","chicago-de":"Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm und Björn Frahm. 2021. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes 9, Nr. 6. doi:10.3390/pr9060964, .","van":"Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes. 2021;9(6).","mla":"Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study.” Processes, vol. 9, no. 6, 964, 2021, https://doi.org/10.3390/pr9060964.","bjps":"Hernández Rodriguez T et al. (2021) Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes 9.","havard":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study, Processes. 9 (2021).","ufg":"Hernández Rodriguez, Tanja u. a.: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study, in: Processes 9 (2021), H. 6.","apa":"Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm, B. (2021). Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes, 9(6), Article 964. https://doi.org/10.3390/pr9060964","chicago":"Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm, and Björn Frahm. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study.” Processes 9, no. 6 (2021). https://doi.org/10.3390/pr9060964."},"volume":9,"title":"Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study","keyword":["clonal cell population","phenotypic diversity","inoculum train","uncertainty-based","cell culture model","biopharmaceutical manufacturing"],"language":[{"iso":"eng"}],"date_updated":"2024-05-21T09:29:02Z","publication":"Processes","publication_identifier":{"eissn":["2227-9717"]},"date_created":"2024-04-25T13:34:26Z","publisher":"MDPI AG","issue":"6","abstract":[{"lang":"eng","text":"concentration is an important objective. The phenotype of the cells in a reactor plays an important role. Are clonal cell populations showing high cell-specific growth rates more favorable than cell lines with higher cell-specific productivities or vice versa? Five clonal Chinese hamster ovary cell populations were analyzed based on the data of a 3-month-stability study. We adapted a mechanistic cell culture model to the experimental data of one such clonally derived cell population. Uncertainties and prior knowledge concerning model parameters were considered using Bayesian parameter estimations. This model was used then to define an inoculum train protocol. Based on this, we subsequently simulated the impacts of differences in growth rates (±10%) and production rates (±10% and ±50%) on the overall cultivation time, including making the inoculum train cultures; the final production phase, the volumetric titer in that bioreactor and the ratio of both, defined as overall process productivity. We showed thus unequivocally that growth rates have a higher impact (up to three times) on overall process productivity and for product output per year, whereas cells with higher productivity can potentially generate higher product concentrations in the production vessel."}],"department":[{"_id":"DEP4000"}],"publication_status":"published","_id":"11376","article_number":"964","doi":"10.3390/pr9060964","place":"Basel","intvolume":" 9","user_id":"83781","type":"scientific_journal_article"},{"issue":"4","abstract":[{"text":"Bioprocess modeling has become a useful tool for prediction of the process future with the aim to deduce operating decisions (e.g. transfer or feeds). Due to variabilities, which often occur between and within batches, updating (re-estimation) of model parameters is required at certain time intervals (dynamic parameter estimation) to obtain reliable predictions. This can be challenging in the presence of low sampling frequencies (e.g. every 24 h), different consecutive scales and large measurement errors, as in the case of cell culture seed trains. This contribution presents an iterative learning workflow which generates and incorporates knowledge concerning cell growth during the process by using a moving horizon estimation (MHE) approach for updating of model parameters. This estimation technique is compared to a classical weighted least squares estimation (WLSE) approach in the context of model updating over three consecutive cultivation scales (40–2160 L) of an industrial cell culture seed train. Both techniques were investigated regarding robustness concerning the aforementioned challenges and the required amount of experimental data (estimation horizon). It is shown how the proposed MHE can deal with the aforementioned difficulties by the integration of prior knowledge, even if only data at two sampling points are available, outperforming the classical WLSE approach. This workflow allows to adequately integrate current process behavior into the model and can therefore be a suitable component of a digital twin.","lang":"eng"}],"department":[{"_id":"DEP4021"}],"publisher":"Springer","quality_controlled":"1","publication_status":"published","_id":"7985","doi":"10.1007/s00449-020-02488-1 ","place":"Berlin ; Heidelberg [u.a.]","type":"scientific_journal_article","intvolume":" 44","user_id":"83781","year":"2021","author":[{"last_name":"Hernández Rodriguez","id":"52466","full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja"},{"full_name":"Posch, Christoph","last_name":"Posch","first_name":"Christoph"},{"last_name":"Pörtner","full_name":"Pörtner, Ralf","first_name":"Ralf"},{"id":"45666","first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn"}],"status":"public","page":"793-808","title":"Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train","volume":44,"citation":{"ama":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering. 2021;44(4):793-808. doi:10.1007/s00449-020-02488-1 ","ieee":"T. Hernández Rodriguez, C. Posch, R. Pörtner, and B. Frahm, “Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train,” Bioprocess and Biosystems Engineering, vol. 44, no. 4, pp. 793–808, 2021, doi: 10.1007/s00449-020-02488-1 .","din1505-2-1":"Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. In: Bioprocess and Biosystems Engineering Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 793–808","chicago-de":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner und Björn Frahm. 2021. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering 44, Nr. 4: 793–808. doi:10.1007/s00449-020-02488-1 , .","short":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Bioprocess and Biosystems Engineering 44 (2021) 793–808.","ufg":"Hernández Rodriguez, Tanja u. a.: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, in: Bioprocess and Biosystems Engineering 44 (2021), H. 4, S. 793–808.","mla":"Hernández Rodriguez, Tanja, et al. “Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train.” Bioprocess and Biosystems Engineering, vol. 44, no. 4, 2021, pp. 793–808, https://doi.org/10.1007/s00449-020-02488-1 .","havard":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, Bioprocess and Biosystems Engineering. 44 (2021) 793–808.","bjps":"Hernández Rodriguez T et al. (2021) Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train. Bioprocess and Biosystems Engineering 44, 793–808.","van":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering. 2021;44(4):793–808.","chicago":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, and Björn Frahm. “Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train.” Bioprocess and Biosystems Engineering 44, no. 4 (2021): 793–808. https://doi.org/10.1007/s00449-020-02488-1 .","apa":"Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2021). Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering, 44(4), 793–808. https://doi.org/10.1007/s00449-020-02488-1 "},"keyword":["Dynamic parameter estimation","Bioprocess","Cell cultures","Moving horizon estimation","Prior knowledge"],"language":[{"iso":"eng"}],"publication":"Bioprocess and Biosystems Engineering","publication_identifier":{"eissn":["1615-7605"],"issn":["1615-7591"]},"date_created":"2022-05-05T13:06:12Z","date_updated":"2023-08-21T07:51:38Z"},{"place":"Berlin ; Heidelberg [u.a.]","_id":"7986","doi":"10.1007/s00449-020-02478-3","user_id":"83781","intvolume":" 44","type":"scientific_journal_article","publisher":"Springer","quality_controlled":"1","department":[{"_id":"DEP4021"}],"abstract":[{"lang":"eng","text":"Bioprocess development and optimization are still cost- and time-intensive due to the enormous number of experiments involved. In this study, the recently introduced model-assisted Design of Experiments (mDoE) concept (Möller et al. in Bioproc Biosyst Eng 42(5):867, https://doi.org/10.1007/s00449-019-02089-7, 2019) was extended and implemented into a software (“mDoE-toolbox”) to significantly reduce the number of required cultivations. The application of the toolbox is exemplary shown in two case studies with Saccharomyces cerevisiae. In the first case study, a fed-batch process was optimized with respect to the pH value and linearly rising feeding rates of glucose and nitrogen source. Using the mDoE-toolbox, the biomass concentration was increased by 30% compared to previously performed experiments. The second case study was the whole-cell biocatalysis of ethyl acetoacetate (EAA) to (S)-ethyl-3-hydroxybutyrate (E3HB), for which the feeding rates of glucose, nitrogen source, and EAA were optimized. An increase of 80% compared to a previously performed experiment with similar initial conditions was achieved for the E3HB concentration."}],"issue":"4","publication_status":"published","keyword":["Biocatalysis","Monte Carlo methods","Fed-batch strategy","Model-assisted design of experiments","Quality by design"],"language":[{"iso":"eng"}],"date_updated":"2023-08-21T07:55:05Z","publication_identifier":{"isbn":["1615-7591"],"eissn":["1615-7605"]},"publication":"Bioprocess and Biosystems Engineering","date_created":"2022-05-05T13:10:11Z","status":"public","page":"683-700","year":"2021","author":[{"last_name":"Moser","first_name":"André","full_name":"Moser, André"},{"full_name":"Kuchemüller, Kim B.","first_name":"Kim B.","last_name":"Kuchemüller"},{"first_name":"Sahar","full_name":"Deppe, Sahar","last_name":"Deppe"},{"first_name":"Tanja","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja","id":"52466"},{"first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn","id":"45666"},{"full_name":"Pörtner, Ralf","last_name":"Pörtner","first_name":"Ralf"},{"full_name":"Hass, Volker C.","last_name":"Hass","first_name":"Volker C."},{"full_name":"Möller, Johannes","first_name":"Johannes","last_name":"Möller"}],"citation":{"ieee":"A. Moser et al., “Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses,” Bioprocess and Biosystems Engineering, vol. 44, no. 4, pp. 683–700, 2021, doi: 10.1007/s00449-020-02478-3.","apa":"Moser, A., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Frahm, B., Pörtner, R., Hass, V. C., & Möller, J. (2021). Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering, 44(4), 683–700. https://doi.org/10.1007/s00449-020-02478-3","chicago":"Moser, André, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Björn Frahm, Ralf Pörtner, Volker C. Hass, and Johannes Möller. “Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses.” Bioprocess and Biosystems Engineering 44, no. 4 (2021): 683–700. https://doi.org/10.1007/s00449-020-02478-3.","ama":"Moser A, Kuchemüller KB, Deppe S, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering. 2021;44(4):683-700. doi:10.1007/s00449-020-02478-3","van":"Moser A, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Frahm B, Pörtner R, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering. 2021;44(4):683–700.","bjps":"Moser A et al. (2021) Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses. Bioprocess and Biosystems Engineering 44, 683–700.","mla":"Moser, André, et al. “Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses.” Bioprocess and Biosystems Engineering, vol. 44, no. 4, 2021, pp. 683–700, https://doi.org/10.1007/s00449-020-02478-3.","havard":"A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, Bioprocess and Biosystems Engineering. 44 (2021) 683–700.","ufg":"Moser, André u. a.: Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, in: Bioprocess and Biosystems Engineering 44 (2021), H. 4, S. 683–700.","short":"A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Bioprocess and Biosystems Engineering 44 (2021) 683–700.","din1505-2-1":"Moser, André ; Kuchemüller, Kim B. ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pörtner, Ralf ; Hass, Volker C. ; Möller, Johannes: Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. In: Bioprocess and Biosystems Engineering Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 683–700","chicago-de":"Moser, André, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Björn Frahm, Ralf Pörtner, Volker C. Hass und Johannes Möller. 2021. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering 44, Nr. 4: 683–700. doi:10.1007/s00449-020-02478-3, ."},"volume":44,"title":"Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses"},{"user_id":"81304","date_updated":"2024-04-15T07:22:55Z","publication":"Seminar Life Science Technologies 2021-04-28","date_created":"2022-05-10T14:02:37Z","type":"conference_speech","language":[{"iso":"eng"}],"_id":"8078","citation":{"chicago":"Blome, André, Mario Luttmann, Björn Frahm, and Ulrich Müller. Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung. Seminar Life Science Technologies 2021-04-28, 2021.","ieee":"A. Blome, M. Luttmann, B. Frahm, and U. Müller, Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. 2021.","apa":"Blome, A., Luttmann, M., Frahm, B., & Müller, U. (2021). Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. In Seminar Life Science Technologies 2021-04-28. Seminar Life Science Technologies, TH OWL, Lemgo, Germany.","havard":"A. Blome, M. Luttmann, B. Frahm, U. Müller, Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung, 2021.","mla":"Blome, André, et al. “Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung.” Seminar Life Science Technologies 2021-04-28, 2021.","bjps":"Blome A et al. (2021) Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung. .","ufg":"Blome, André u. a.: Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung, o. O. 2021.","ama":"Blome A, Luttmann M, Frahm B, Müller U. Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung.; 2021.","van":"Blome A, Luttmann M, Frahm B, Müller U. Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. Seminar Life Science Technologies 2021-04-28. 2021.","chicago-de":"Blome, André, Mario Luttmann, Björn Frahm und Ulrich Müller. 2021. Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. Seminar Life Science Technologies 2021-04-28.","din1505-2-1":"Blome, André ; Luttmann, Mario ; Frahm, Björn ; Müller, Ulrich: Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung, 2021","short":"A. Blome, M. Luttmann, B. Frahm, U. Müller, Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung, 2021."},"title":"Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung","status":"public","author":[{"first_name":"André","last_name":"Blome","full_name":"Blome, André","id":"62117"},{"first_name":"Mario","last_name":"Luttmann","full_name":"Luttmann, Mario","id":"63215"},{"id":"45666","last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn"},{"full_name":"Müller, Ulrich","id":"12119","first_name":"Ulrich","last_name":"Müller"}],"year":"2021","conference":{"name":"Seminar Life Science Technologies, TH OWL","location":"Lemgo, Germany","end_date":"2021-04-28"},"department":[{"_id":"DEP4021"},{"_id":"DEP1308"}]},{"language":[{"iso":"eng"}],"keyword":["Bayes","Digital twin","Parameter estimation","Seed train","Uncertainty"],"date_updated":"2023-08-16T06:48:35Z","editor":[{"last_name":"Herwig","first_name":"Christoph ","full_name":"Herwig, Christoph "},{"first_name":"Ralf ","full_name":"Pörtner, Ralf ","last_name":"Pörtner"},{"full_name":"Möller, Johannes ","last_name":"Möller","first_name":"Johannes "}],"date_created":"2020-08-19T07:14:11Z","publication":"Digital Twins Tools and Concepts for Smart Biomanufacturing","publication_identifier":{"eisbn":["978-3-030-71660-8"],"issn":["0724-6145"],"eissn":["1616-8542"],"isbn":["978-3-030-71659-2"]},"page":"97–131","status":"public","author":[{"first_name":"Tanja","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja","id":"52466"},{"first_name":"Björn","id":"45666","full_name":"Frahm, Björn","last_name":"Frahm"}],"year":"2021","citation":{"ieee":"T. Hernández Rodriguez and B. Frahm, “Digital Seed Train Twins and Statistical Methods,” in Digital Twins Tools and Concepts for Smart Biomanufacturing, vol. 176, C. Herwig, R. Pörtner, and J. Möller, Eds. Berlin, Heidelberg: Springer, 2021, pp. 97–131. doi: https://doi.org/10.1007/10_2020_137.","ama":"Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, eds. Digital Twins Tools and Concepts for Smart Biomanufacturing. Vol 176. Advances in Biochemical Engineering/Biotechnology. Springer; 2021:97-131. doi:https://doi.org/10.1007/10_2020_137","short":"T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021, pp. 97–131.","chicago-de":"Hernández Rodriguez, Tanja und Björn Frahm. 2021. Digital Seed Train Twins and Statistical Methods. In: Digital Twins Tools and Concepts for Smart Biomanufacturing, hg. von Christoph Herwig, Ralf Pörtner, und Johannes Möller, 176:97–131. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer. doi:https://doi.org/10.1007/10_2020_137, .","din1505-2-1":"Hernández Rodriguez, Tanja ; Frahm, Björn: Digital Seed Train Twins and Statistical Methods. In: Herwig, C. ; Pörtner, R. ; Möller, J. (Hrsg.): Digital Twins Tools and Concepts for Smart Biomanufacturing, Advances in Biochemical Engineering/Biotechnology. Bd. 176. Berlin, Heidelberg : Springer, 2021, S. 97–131","apa":"Hernández Rodriguez, T., & Frahm, B. (2021). Digital Seed Train Twins and Statistical Methods. In C. Herwig, R. Pörtner, & J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing (Vol. 176, pp. 97–131). Springer. https://doi.org/10.1007/10_2020_137","chicago":"Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins and Statistical Methods.” In Digital Twins Tools and Concepts for Smart Biomanufacturing, edited by Christoph Herwig, Ralf Pörtner, and Johannes Möller, 176:97–131. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer, 2021. https://doi.org/10.1007/10_2020_137.","van":"Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, editors. Digital Twins Tools and Concepts for Smart Biomanufacturing. Berlin, Heidelberg: Springer; 2021. p. 97–131. (Advances in Biochemical Engineering/Biotechnology; vol. 176).","bjps":"Hernández Rodriguez T and Frahm B (2021) Digital Seed Train Twins and Statistical Methods. In Herwig C, Pörtner R and Möller J (eds), Digital Twins Tools and Concepts for Smart Biomanufacturing, vol. 176. Berlin, Heidelberg: Springer, pp. 97–131.","havard":"T. Hernández Rodriguez, B. Frahm, Digital Seed Train Twins and Statistical Methods, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021: pp. 97–131.","mla":"Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins and Statistical Methods.” Digital Twins Tools and Concepts for Smart Biomanufacturing, edited by Christoph Herwig et al., vol. 176, Springer, 2021, pp. 97–131, https://doi.org/10.1007/10_2020_137.","ufg":"Hernández Rodriguez, Tanja/Frahm, Björn: Digital Seed Train Twins and Statistical Methods, in: Herwig, Christoph/Pörtner, Ralf/Möller, Johannes (Hgg.): Digital Twins Tools and Concepts for Smart Biomanufacturing, Bd. 176, Berlin, Heidelberg 2021 (Advances in Biochemical Engineering/Biotechnology), S. 97–131."},"volume":176,"title":"Digital Seed Train Twins and Statistical Methods","place":"Berlin, Heidelberg","doi":"https://doi.org/10.1007/10_2020_137","_id":"3349","user_id":"83781","intvolume":" 176","type":"book_chapter","quality_controlled":"1","publisher":"Springer","department":[{"_id":"DEP4021"}],"abstract":[{"lang":"eng","text":"Model-based concepts and simulation techniques in combination with digital tools emerge as a key to explore the full potential of biopharmaceutical production processes, which contain several challenging development and process steps. One of these steps is the time- and cost-intensive cell proliferation process (also called seed train) to increase cell number from cell thawing up to production scale. Challenges like complex cell metabolism, batch-to-batch variation, variabilities in cell behavior, and influences of changes in cultivation conditions necessitate adequate digital solutions to provide information about the current and near future process state to derive correct process decisions.\r\nFor this purpose digital seed train twins have proved to be efficient, which digitally display the time-dependent behavior of important process variables based on mathematical models, strategies, and adaption procedures.\r\nThis chapter will outline the needs for digitalization of seed trains, the construction of a digital seed train twin, the role of parameter estimation, and different statistical methods within this context, which are applicable to several problems in the field of bioprocessing. The results of a case study are presented to illustrate a Bayesian approach for parameter estimation and prediction of an industrial cell culture seed train for seed train digitalization."}],"publication_status":"published","series_title":"Advances in Biochemical Engineering/Biotechnology"},{"author":[{"first_name":"Tanja","last_name":"Hernández Rodriguez","id":"52466","full_name":"Hernández Rodriguez, Tanja"},{"last_name":"Deppe","full_name":"Deppe, Sahar","first_name":"Sahar"},{"full_name":"Gassenmeier, Veronika","id":"74048","first_name":"Veronika","last_name":"Gassenmeier"},{"last_name":"Kuhfuß","full_name":"Kuhfuß, Fabian","first_name":"Fabian"},{"first_name":"Marius","last_name":"Tölle","full_name":"Tölle, Marius"},{"last_name":"Ifrim","id":"73814","full_name":"Ifrim, George Adrian","first_name":"George Adrian"},{"last_name":"Frahm","first_name":"Björn","id":"45666","full_name":"Frahm, Björn"}],"year":2020,"conference":{"end_date":"2020-09-24","start_date":"2020-09-21","name":"10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020","location":"als Web-Konferenz, Aachen, Germany"},"department":[{"_id":"DEP4021"}],"status":"public","title":"Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration","citation":{"chicago":"Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim, and Björn Frahm. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.","apa":"Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.","ufg":"Hernández Rodriguez, Tanja et. al. (2020): Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration.","bjps":"Hernández Rodriguez T et al. (2020) Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. .","havard":"T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020.","mla":"Hernández Rodriguez, Tanja, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. 2020.","van":"Hernández Rodriguez T, Deppe S, Gassenmeier V, Kuhfuß F, Tölle M, Ifrim GA, et al. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020.","din1505-2-1":"Hernández Rodriguez, Tanja ; Deppe, Sahar ; Gassenmeier, Veronika ; Kuhfuß, Fabian ; Tölle, Marius ; Ifrim, George Adrian ; Frahm, Björn: Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020","chicago-de":"Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim und Björn Frahm. 2020. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration.","short":"T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.","ieee":"T. Hernández Rodriguez et al., Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020.","ama":"Hernández Rodriguez T, Deppe S, Gassenmeier V, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration.; 2020."},"language":[{"iso":"eng"}],"_id":"7929","date_created":"2022-05-04T19:22:33Z","type":"conference_poster","user_id":"45673","date_updated":"2023-03-15T13:50:12Z"},{"language":[{"iso":"eng"}],"_id":"7930","user_id":"45666","date_updated":"2023-03-15T13:50:12Z","date_created":"2022-05-04T19:26:13Z","type":"conference_poster","status":"public","year":2020,"author":[{"full_name":"Hernández Rodriguez, Tanja","id":"52466","first_name":"Tanja","last_name":"Hernández Rodriguez"},{"full_name":"Posch, Christoph","first_name":"Christoph","last_name":"Posch"},{"first_name":"Ralf","full_name":"Pörtner, Ralf","last_name":"Pörtner"},{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"}],"department":[{"_id":"DEP4021"}],"conference":{"start_date":"2020-09-21","end_date":"2020-09-24","name":"10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020","location":"als Web-Konferenz, Aachen, Germany"},"citation":{"din1505-2-1":"Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020","chicago-de":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner und Björn Frahm. 2020. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes.","short":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020.","chicago":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, and Björn Frahm. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020.","apa":"Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.","ufg":"Hernández Rodriguez, Tanja et. al. (2020): Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes.","havard":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020.","bjps":"Hernández Rodriguez T et al. (2020) Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. .","mla":"Hernández Rodriguez, Tanja, et al. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. 2020.","van":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. 2020.","ieee":"T. Hernández Rodriguez, C. Posch, R. Pörtner, and B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. 2020.","ama":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes.; 2020."},"title":"Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes"},{"author":[{"last_name":"Hernández Rodriguez","id":"52466","full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja"},{"first_name":"Björn","id":"45666","full_name":"Frahm, Björn","last_name":"Frahm"},{"first_name":"Christoph","full_name":"Posch, Christoph","last_name":"Posch"}],"year":2020,"conference":{"location":"Sandoz, Austria","name":"1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable","start_date":"2020-06-03"},"department":[{"_id":"DEP4021"}],"status":"public","title":"Integration of prior knowledge and digital tools for uncertainty-based decision support","citation":{"ama":"Hernández Rodriguez T, Frahm B, Posch C. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support.; 2020.","van":"Hernández Rodriguez T, Frahm B, Posch C. Integration of prior knowledge and digital tools for uncertainty-based decision support. 2020.","bjps":"Hernández Rodriguez T, Frahm B and Posch C (2020) Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support. .","havard":"T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020.","mla":"Hernández Rodriguez, Tanja, et al. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support. 2020.","ufg":"Hernández Rodriguez, Tanja et. al. (2020): Integration of prior knowledge and digital tools for uncertainty-based decision support.","ieee":"T. Hernández Rodriguez, B. Frahm, and C. Posch, Integration of prior knowledge and digital tools for uncertainty-based decision support. 2020.","apa":"Hernández Rodriguez, T., Frahm, B., & Posch, C. (2020). Integration of prior knowledge and digital tools for uncertainty-based decision support. Presented at the 1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable, Sandoz, Austria.","chicago":"Hernández Rodriguez, Tanja, Björn Frahm, and Christoph Posch. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support, 2020.","short":"T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support, 2020.","chicago-de":"Hernández Rodriguez, Tanja, Björn Frahm und Christoph Posch. 2020. Integration of prior knowledge and digital tools for uncertainty-based decision support.","din1505-2-1":"Hernández Rodriguez, Tanja ; Frahm, Björn ; Posch, Christoph: Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020"},"_id":"7936","language":[{"iso":"eng"}],"date_created":"2022-05-04T19:47:05Z","type":"conference_speech","user_id":"45666","date_updated":"2023-03-15T13:50:12Z"},{"series_title":"Volume 92","title":"Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration","volume":"No. 9","citation":{"ama":"Hernández Rodriguez T, Deppe S, Gassenmeier V, et al. Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration. Vol No. 9. Wiley; 2020:1225 – 1226. doi:10.1002/cite.202055235","ieee":"T. Hernández Rodriguez et al., Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration, vol. No. 9. 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Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, 2013.","chicago-de":"Hernández Rodriguez, Tanja, R. Pörtner und Björn Frahm. 2013. Seed train optimization for suspension cell culture.","din1505-2-1":"Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: Seed train optimization for suspension cell culture, 2013","van":"Hernández Rodriguez T, Pörtner R, Frahm B. Seed train optimization for suspension cell culture. 2013.","ama":"Hernández Rodriguez T, Pörtner R, Frahm B. Seed Train Optimization for Suspension Cell Culture.; 2013.","ufg":"Hernández Rodriguez, Tanja et. al. (2013): Seed train optimization for suspension cell culture.","mla":"Hernández Rodriguez, Tanja, et al. Seed Train Optimization for Suspension Cell Culture. 2013.","havard":"T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, 2013.","bjps":"Hernández Rodriguez T, Pörtner R and Frahm B (2013) Seed Train Optimization for Suspension Cell Culture. .","apa":"Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.","ieee":"T. Hernández Rodriguez, R. Pörtner, and B. Frahm, Seed train optimization for suspension cell culture. 2013.","chicago":"Hernández Rodriguez, Tanja, R. Pörtner, and Björn Frahm. Seed Train Optimization for Suspension Cell Culture, 2013."},"publication_status":"published","title":"Seed train optimization for suspension cell culture"},{"type":"book_chapter","user_id":"83781","intvolume":" 1104","place":"Totowa, NJ","_id":"10214","doi":"10.1007/978-1-62703-733-4_22","series_title":"Methods in Molecular Biology","publication_status":"published","department":[{"_id":"DEP4000"}],"abstract":[{"text":"For the production of biopharmaceuticals a seed train is required to generate an adequate number of cells for inoculation of the production bioreactor. This seed train is time- and cost-intensive but offers potential for optimization. A method and a protocol are described for the seed train mapping, directed modeling without major effort, and its optimization regarding selected optimization criteria such as optimal points in time for cell passaging. Furthermore, the method can also be applied for the set-up of a new seed train, for example for a new cell line. Although the chapter is directed towards suspension cell lines, the method is also generally applicable, e.g. for adherent cell lines.","lang":"eng"}],"publisher":"Humana Press","publication":"Animal Cell Biotechnology - Methods and Protocols","publication_identifier":{"eissn":["1940-6029"],"isbn":["978-1-62703-732-7"],"issn":["1064-3745"],"eisbn":["978-1-62703-733-4"]},"date_created":"2023-08-14T17:50:56Z","edition":"3","date_updated":"2023-08-16T06:41:21Z","editor":[{"full_name":"Pörtner, Ralf","last_name":"Pörtner","first_name":"Ralf"}],"keyword":["Seed train","Optimization","Modeling","Prediction","Space-Time-Yield (STY)","Systems approach","Bioinformatics","Computational biotechnology","Suspension","Production"],"language":[{"iso":"eng"}],"title":"Seed Train Optimization for Cell Culture","volume":1104,"citation":{"chicago":"Frahm, Björn. “Seed Train Optimization for Cell Culture.” In Animal Cell Biotechnology - Methods and Protocols, edited by Ralf Pörtner, 3rd ed., 1104:355–67. 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(Hrsg.): Animal Cell Biotechnology - Methods and Protocols, Methods in Molecular Biology. Bd. 1104. 3. Aufl. Totowa, NJ : Humana Press, 2013, S. 355–367","short":"B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013, pp. 355–367.","ieee":"B. Frahm, “Seed Train Optimization for Cell Culture,” in Animal Cell Biotechnology - Methods and Protocols, 3rd ed., vol. 1104, R. Pörtner, Ed. Totowa, NJ: Humana Press, 2013, pp. 355–367. doi: 10.1007/978-1-62703-733-4_22.","ama":"Frahm B. Seed Train Optimization for Cell Culture. In: Pörtner R, ed. Animal Cell Biotechnology - Methods and Protocols. Vol 1104. 3rd ed. Methods in Molecular Biology. Humana Press; 2013:355-367. doi:10.1007/978-1-62703-733-4_22"},"author":[{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"}],"year":"2013","status":"public","page":"355–367"},{"conference":{"start_date":"2009-06-07","end_date":"2009-06-10","name":"21st Annual Meeting of the European Society for Animal Cell Technology (ESACT)","location":" Dublin, Ireland"},"department":[{"_id":"DEP4021"}],"publisher":"Springer","series_title":"ESACT Proceedings","publication_status":"published","_id":"2816","doi":"10.1007/978-94-007-0884-6_56","place":"Dordrecht","type":"conference_editor_article","user_id":"45666","main_file_link":[{"open_access":"1","url":"https://link.springer.com/book/10.1007%2F978-94-007-0884-6"}],"year":2012,"author":[{"id":"45666","last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn"},{"full_name":"Brod, H.","first_name":"H.","last_name":"Brod"}],"status":"public","page":"355-359","title":"Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA)","extern":"1","citation":{"ama":"Frahm B, Brod H. 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Dordrecht: Springer. doi:10.1007/978-94-007-0884-6_56, .","din1505-2-1":"Frahm, Björn ; Brod, H.: Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA), ESACT Proceedings. Bd. 5. Dordrecht : Springer, 2012","van":"Frahm B, Brod H. Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. Dordrecht: Springer; 2012. (ESACT Proceedings; vol. 5).","mla":"Frahm, Björn, and H. Brod. “Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA).” Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009, vol. 5, Springer, 2012, pp. 355–59, doi:10.1007/978-94-007-0884-6_56.","havard":"B. Frahm, H. 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Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. Vol. 5. ESACT Proceedings. Dordrecht: Springer, 2012. https://doi.org/10.1007/978-94-007-0884-6_56."},"volume":"vol. 5","oa":"1","language":[{"iso":"eng"}],"publication_identifier":{"isbn":["978-94-007-0883-9"],"eissn":["978-94-007-0884-6"]},"publication":"Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009","date_created":"2020-06-04T13:19:37Z","date_updated":"2023-03-15T13:49:43Z"},{"date_updated":"2023-03-15T13:49:43Z","user_id":"45666","date_created":"2020-06-05T14:32:12Z","type":"patent","_id":"2877","alternative_title":["Photo-bioreactor with rotary oscillating light sources"],"ipc":"C12M 1/00 ","ipn":"EP000002520642A1","citation":{"short":"H. Brod, B. Frahm, (2012).","chicago-de":"Brod, Helmut und Björn Frahm. 2012. Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.","din1505-2-1":"Brod, Helmut ; Frahm, Björn: Photobioreaktor mit rotatorisch oszillierenden Lichtquellen (2012)","apa":"Brod, H., & Frahm, B. (2012). Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.","chicago":"Brod, Helmut, and Björn Frahm. “Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen,” 2012.","van":"Brod H, Frahm B. Photobioreaktor mit rotatorisch oszillierenden Lichtquellen. 2012.","ufg":"Brod, Helmut/Frahm, Björn (2012): Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.","mla":"Brod, Helmut, and Björn Frahm. Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen. 2012.","bjps":"Brod H and Frahm B (2012) Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen.","havard":"H. Brod, B. Frahm, Photobioreaktor mit rotatorisch oszillierenden Lichtquellen, (2012).","ieee":"H. Brod and B. Frahm, “Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.” 2012.","ama":"Brod H, Frahm B. Photobioreaktor mit rotatorisch oszillierenden Lichtquellen. 2012."},"application_number":" \t12166475","extern":"1","title":"Photobioreaktor mit rotatorisch oszillierenden Lichtquellen","publication_date":"2012-11-07","page":"19","status":"public","application_date":"2012-05-02","abstract":[{"lang":"ger","text":"Die Erfindung betrifft einen Photobioreaktor mit Belichtung durch rotatorisch oszillierend bewegte Lichtquellen (Lichtleiter, LEDs) sowie optional kombiniert rotatorisch oszillierend bewegte Membranflächen zum Gastransport. Vorteile sind unter anderem ein im zeitlichen Mittel räumlich homogener Lichteintrag, welcher über Intensität und Oszillation an die Kultur und deren Dichte angepasst werden kann, sowie ein scherarmer Leistungseintrag und optional eine scherarme blasenfreie Be- und Entgasung. "},{"lang":"eng","text":"Photobioreactor comprises light sources, which are arbitrarily movable in rotational oscillation distributed in a bioreactor liquid volume. An independent claim is also included for using the photobioreactor, comprising executing an arbitrary discontinuous movement using the light sources. "}],"department":[{"_id":"DEP4021"}],"year":2012,"author":[{"full_name":"Brod, Helmut","first_name":"Helmut","last_name":"Brod"},{"full_name":"Frahm, Björn","first_name":"Björn","id":"45666","last_name":"Frahm"}]},{"_id":"2918","language":[{"iso":"eng"}],"user_id":"45666","date_updated":"2023-03-15T13:49:43Z","publication":"Achema 2012","type":"conference_speech","date_created":"2020-06-15T14:30:34Z","publisher":"Vogel Business Media","status":"public","year":2012,"author":[{"full_name":"Van Hecke, W.","first_name":"W.","last_name":"Van Hecke"},{"last_name":"Haltrich","first_name":"D.","full_name":"Haltrich, D."},{"last_name":"Frahm","full_name":"Frahm, Björn","id":"45666","first_name":"Björn"},{"full_name":"Brod, H.","last_name":"Brod","first_name":"H."},{"first_name":"R.","last_name":"Ludwig","full_name":"Ludwig, R."}],"department":[{"_id":"DEP4021"}],"conference":{"location":"Frankfurt am Main, Germany","name":"ACHEMA 2012","end_date":"2012-06-22","start_date":"2012-06-18"},"citation":{"ama":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. Vogel Business Media; 2012.","ieee":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, and R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Vogel Business Media, 2012.","ufg":"Van Hecke, W. et. al. (2012): Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor.","mla":"Van Hecke, W., et al. “Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor.” Achema 2012, Vogel Business Media, 2012.","havard":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor, Vogel Business Media, 2012.","bjps":"Van Hecke W et al. (2012) Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. Vogel Business Media.","van":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Achema 2012. Vogel Business Media; 2012.","chicago":"Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod, and R. Ludwig. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. Achema 2012. Vogel Business Media, 2012.","apa":"Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., & Ludwig, R. (2012). Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Achema 2012. Frankfurt am Main, Germany: Vogel Business Media.","din1505-2-1":"Van Hecke, W. ; Haltrich, D. ; Frahm, Björn ; Brod, H. ; Ludwig, R.: Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor : Vogel Business Media, 2012","chicago-de":"Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod und R. Ludwig. 2012. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Achema 2012. Vogel Business Media.","short":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, Vogel Business Media, 2012."},"publication_status":"published","title":"Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor"},{"publication_status":"published","citation":{"apa":"Marzougui, R., Pörtner, R., & Frahm, B. (2012). Optimierung des Seed trains von Suspensions-Zellkulturen. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung “Biopharmazeutische Produktion,” Freiburg, Germany.","ieee":"R. Marzougui, R. Pörtner, and B. Frahm, Optimierung des Seed trains von Suspensions-Zellkulturen. 2012.","chicago":"Marzougui, R., R. Pörtner, and Björn Frahm. Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.","van":"Marzougui R, Pörtner R, Frahm B. Optimierung des Seed trains von Suspensions-Zellkulturen. 2012.","ama":"Marzougui R, Pörtner R, Frahm B. Optimierung des Seed trains von Suspensions-Zellkulturen.; 2012.","ufg":"Marzougui, R. et. al. (2012): Optimierung des Seed trains von Suspensions-Zellkulturen.","havard":"R. Marzougui, R. Pörtner, B. Frahm, Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.","bjps":"Marzougui R, Pörtner R and Frahm B (2012) Optimierung des Seed trains von Suspensions-Zellkulturen. .","mla":"Marzougui, R., et al. Optimierung des Seed trains von Suspensions-Zellkulturen. 2012.","short":"R. Marzougui, R. Pörtner, B. Frahm, Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.","chicago-de":"Marzougui, R., R. Pörtner und Björn Frahm. 2012. Optimierung des Seed trains von Suspensions-Zellkulturen.","din1505-2-1":"Marzougui, R. ; Pörtner, R. ; Frahm, Björn: Optimierung des Seed trains von Suspensions-Zellkulturen, 2012"},"title":"Optimierung des Seed trains von Suspensions-Zellkulturen","status":"public","department":[{"_id":"DEP4021"}],"conference":{"end_date":"2012-05-16","start_date":"2012-05-14","name":"GVC / DECHEMA Vortrags- und Diskussionstagung “Biopharmazeutische Produktion”","location":"Freiburg, Germany"},"author":[{"first_name":"R.","full_name":"Marzougui, R.","last_name":"Marzougui"},{"first_name":"R.","full_name":"Pörtner, R.","last_name":"Pörtner"},{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"}],"year":2012,"date_updated":"2023-03-15T13:49:44Z","user_id":"45666","date_created":"2020-06-18T14:31:21Z","type":"conference_poster","_id":"2973","language":[{"iso":"ger"}]},{"title":"A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor","extern":"1","volume":68,"citation":{"ama":"Van Hecke W, Haltrich D, Frahm B, et al. A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic. 2011;68(2):154-161. doi:10.1016/j.molcatb.2010.10.004","ieee":"W. Van Hecke et al., “A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor,” Journal of Molecular Catalysis B: Enzymatic, vol. 68, no. 2, pp. 154–161, 2011.","din1505-2-1":"Van Hecke, Wouter ; Haltrich, Dietmar ; Frahm, Björn ; Brod, Helmut ; Dewulf, Jo ; Van Langenhove, Herman ; Ludwig, Roland: A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. In: Journal of Molecular Catalysis B: Enzymatic Bd. 68, Elsevier (2011), Nr. 2, S. 154–161","chicago-de":"Van Hecke, Wouter, Dietmar Haltrich, Björn Frahm, Helmut Brod, Jo Dewulf, Herman Van Langenhove und Roland Ludwig. 2011. A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic 68, Nr. 2: 154–161. doi:10.1016/j.molcatb.2010.10.004, .","short":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, J. Dewulf, H. Van Langenhove, R. Ludwig, Journal of Molecular Catalysis B: Enzymatic 68 (2011) 154–161.","bjps":"Van Hecke W et al. (2011) A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor. Journal of Molecular Catalysis B: Enzymatic 68, 154–161.","mla":"Van Hecke, Wouter, et al. “A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor.” Journal of Molecular Catalysis B: Enzymatic, vol. 68, no. 2, Elsevier, 2011, pp. 154–61, doi:10.1016/j.molcatb.2010.10.004.","havard":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, J. Dewulf, H. Van Langenhove, R. Ludwig, A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor, Journal of Molecular Catalysis B: Enzymatic. 68 (2011) 154–161.","ufg":"Van Hecke, Wouter et. al. (2011): A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor, in: Journal of Molecular Catalysis B: Enzymatic 68 (2), S. 154–161.","van":"Van Hecke W, Haltrich D, Frahm B, Brod H, Dewulf J, Van Langenhove H, et al. A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic. 2011;68(2):154–61.","chicago":"Van Hecke, Wouter, Dietmar Haltrich, Björn Frahm, Helmut Brod, Jo Dewulf, Herman Van Langenhove, and Roland Ludwig. “A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor.” Journal of Molecular Catalysis B: Enzymatic 68, no. 2 (2011): 154–61. https://doi.org/10.1016/j.molcatb.2010.10.004.","apa":"Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., Dewulf, J., Van Langenhove, H., & Ludwig, R. (2011). A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic, 68(2), 154–161. https://doi.org/10.1016/j.molcatb.2010.10.004"},"main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S1381117710002663"}],"author":[{"full_name":"Van Hecke, Wouter","first_name":"Wouter","last_name":"Van Hecke"},{"full_name":"Haltrich, Dietmar","first_name":"Dietmar","last_name":"Haltrich"},{"last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn","id":"45666"},{"first_name":"Helmut","last_name":"Brod","full_name":"Brod, Helmut"},{"first_name":"Jo","full_name":"Dewulf, Jo","last_name":"Dewulf"},{"last_name":"Van Langenhove","full_name":"Van Langenhove, Herman","first_name":"Herman"},{"first_name":"Roland","full_name":"Ludwig, Roland","last_name":"Ludwig"}],"year":2011,"status":"public","page":"154-161","publication_identifier":{"eisbn":["1873-3158"],"issn":["1381-1177"]},"publication":"Journal of Molecular Catalysis B: Enzymatic","date_created":"2020-05-15T10:21:22Z","date_updated":"2023-03-15T13:49:39Z","language":[{"iso":"eng"}],"publication_status":"published","issue":"2","department":[{"_id":"DEP4021"}],"publisher":"Elsevier","quality_controlled":"1","type":"scientific_journal_article","intvolume":" 68","user_id":"45666","_id":"2350","doi":"10.1016/j.molcatb.2010.10.004"},{"date_updated":"2023-03-15T13:49:43Z","user_id":"45666","date_created":"2020-06-05T14:28:44Z","type":"patent","_id":"2876","ipc":"C12M 1/08 ","alternative_title":["Liquid Aerator"],"ipn":"O002011032652A1 ","citation":{"van":"Brod H, Frahm B, Jenne M, Kauling J, Schmitt F, Seletzky J. Flüssigkeitsbegaser. 2011.","ufg":"Brod, Helmut et. al. (2011): Flüssigkeitsbegaser.","bjps":"Brod H et al. (2011) Flüssigkeitsbegaser.","havard":"H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, J. Seletzky, Flüssigkeitsbegaser, (2011).","mla":"Brod, Helmut, et al. Flüssigkeitsbegaser. 2011.","apa":"Brod, H., Frahm, B., Jenne, M., Kauling, J., Schmitt, F., & Seletzky, J. (2011). Flüssigkeitsbegaser.","chicago":"Brod, Helmut, Björn Frahm, Marc Jenne, Jörg Kauling, Franz Schmitt, and Juri Seletzky. “Flüssigkeitsbegaser,” 2011.","short":"H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, J. Seletzky, (2011).","din1505-2-1":"Brod, Helmut ; Frahm, Björn ; Jenne, Marc ; Kauling, Jörg ; Schmitt, Franz ; Seletzky, Juri: Flüssigkeitsbegaser (2011)","chicago-de":"Brod, Helmut, Björn Frahm, Marc Jenne, Jörg Kauling, Franz Schmitt und Juri Seletzky. 2011. Flüssigkeitsbegaser.","ama":"Brod H, Frahm B, Jenne M, Kauling J, Schmitt F, Seletzky J. Flüssigkeitsbegaser. 2011.","ieee":"H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, and J. Seletzky, “Flüssigkeitsbegaser.” 2011."},"application_number":"2010005442 ","extern":"1","title":"Flüssigkeitsbegaser","publication_date":"2011-03-24","page":"32","status":"public","application_date":"2010-09-04","abstract":[{"text":"Die Erfindung betrifft einen Begaser zum Eintrag eines Gases oder Gasgemisches in eine Flüssigkeit sowie ein Verfahren zur Begasung von Flüssigkeiten. Der erf?ndungsgemäße Begaser umfasst einen Hohlraum, einen Gaseinlass zum Einleiten eines Gases in den Hohlraum und zwei oder mehr Flächen, die formschlüssig aufeinander gepresst sind oder gepresst werden können, so dass ein durch den Gaseinlass in den Hohlraum gedrücktes Gas durch die zwischen den zusammengepressten Flächen auftretenden Spalten entweicht. ","lang":"ger"},{"lang":"eng","text":" The invention relates to an aerator for introducing a gas or gas mixture into a liquid and to a method for aerating liquids. The aerator according to the invention comprises a cavity, a gas inlet for directing a gas into the cavity and two or more surfaces that are or can be pressed against one another in a form-fit such that a gas that is forced into the cavity by means of the gas inlet escapes through gaps that form between the compressed surfaces. "}],"department":[{"_id":"DEP4021"}],"author":[{"last_name":"Brod","first_name":"Helmut","full_name":"Brod, Helmut"},{"last_name":"Frahm","id":"45666","full_name":"Frahm, Björn","first_name":"Björn"},{"last_name":"Jenne","first_name":"Marc","full_name":"Jenne, Marc"},{"first_name":"Jörg","full_name":"Kauling, Jörg","last_name":"Kauling"},{"first_name":"Franz","full_name":"Schmitt, Franz","last_name":"Schmitt"},{"first_name":"Juri","last_name":"Seletzky","full_name":"Seletzky, Juri"}],"year":2011},{"status":"public","conference":{"name":"1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting","location":"Berlin, Germany","end_date":"2011-09-29","start_date":"2011-09-25"},"department":[{"_id":"DEP4021"}],"year":2011,"author":[{"last_name":"Van Hecke","full_name":"Van Hecke, W.","first_name":"W."},{"last_name":"Haltrich","first_name":"D.","full_name":"Haltrich, D."},{"id":"45666","last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn"},{"full_name":"Brod, H.","last_name":"Brod","first_name":"H."},{"first_name":"R.","last_name":"Ludwig","full_name":"Ludwig, R."}],"publication_status":"published","citation":{"ieee":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, and R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. 2011.","ama":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor.; 2011.","chicago":"Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod, and R. Ludwig. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, 2011.","apa":"Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., & Ludwig, R. (2011). Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Presented at the 1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting, Berlin, Germany.","ufg":"Van Hecke, W. et. al. (2011): Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor.","mla":"Van Hecke, W., et al. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. 2011.","bjps":"Van Hecke W et al. (2011) Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. .","havard":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor, 2011.","van":"Van Hecke W, Haltrich D, Frahm B, Brod H, Ludwig R. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. 2011.","chicago-de":"Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod und R. Ludwig. 2011. Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor.","din1505-2-1":"Van Hecke, W. ; Haltrich, D. ; Frahm, Björn ; Brod, H. ; Ludwig, R.: Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor, 2011","short":"W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, 2011."},"extern":"1","title":"Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor","language":[{"iso":"eng"}],"_id":"2972","date_updated":"2023-03-15T13:49:44Z","user_id":"45666","date_created":"2020-06-18T14:28:39Z","type":"conference_poster"},{"citation":{"short":"B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, Czech Society of Chemical Engineering, 2010.","din1505-2-1":"Dercks, B. ; Frahm, Björn ; Grünewald, M. ; Kenig, E. ; Lautenschleger, A. ; Gorak, A. ; Schmidt, P. ; Sudhoff, D. ; u. a.: Intensified absorption and distillation devices for modular chemical production processes : Czech Society of Chemical Engineering, 2010","chicago-de":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler und R. Zecirovic. 2010. Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering.","apa":"Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Prague, CZ: Czech Society of Chemical Engineering.","ieee":"B. Dercks et al., Intensified absorption and distillation devices for modular chemical production processes. Czech Society of Chemical Engineering, 2010.","chicago":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, and R. Zecirovic. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering, 2010.","van":"Dercks B, Frahm B, Grünewald M, Kenig E, Lautenschleger A, Gorak A, et al. Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering; 2010.","ama":"Dercks B, Frahm B, Grünewald M, et al. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. Czech Society of Chemical Engineering; 2010.","ufg":"Dercks, B. et. al. (2010): Intensified absorption and distillation devices for modular chemical production processes.","bjps":"Dercks B et al. (2010) Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. Czech Society of Chemical Engineering.","mla":"Dercks, B., et al. “Intensified Absorption and Distillation Devices for Modular Chemical Production Processes.” Proceedings 19th International Congress of Chemical and Process Engineering, Czech Society of Chemical Engineering, 2010.","havard":"B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified absorption and distillation devices for modular chemical production processes, Czech Society of Chemical Engineering, 2010."},"publication_status":"published","title":"Intensified absorption and distillation devices for modular chemical production processes","extern":"1","status":"public","publisher":"Czech Society of Chemical Engineering","year":2010,"author":[{"first_name":"B.","last_name":"Dercks","full_name":"Dercks, B."},{"full_name":"Frahm, Björn","first_name":"Björn","id":"45666","last_name":"Frahm"},{"first_name":"M.","last_name":"Grünewald","full_name":"Grünewald, M."},{"last_name":"Kenig","first_name":"E.","full_name":"Kenig, E."},{"last_name":"Lautenschleger","full_name":"Lautenschleger, A.","first_name":"A."},{"last_name":"Gorak","first_name":"A.","full_name":"Gorak, A."},{"last_name":"Schmidt","first_name":"P. ","full_name":"Schmidt, P. "},{"last_name":"Sudhoff","full_name":"Sudhoff, D.","first_name":"D."},{"first_name":"S.","full_name":"Ressler, S.","last_name":"Ressler"},{"last_name":"Zecirovic","first_name":"R.","full_name":"Zecirovic, R."}],"conference":{"location":"Prague, CZ","name":"7th European Congress of Chemical Engineering ; 19th International Congress of Chemical and Process Engineering","start_date":"2010-08-28","end_date":"2010-09-01"},"department":[{"_id":"DEP4021"}],"user_id":"45666","date_updated":"2023-03-15T13:49:43Z","publication_identifier":{"isbn":["978-80-02-02250-3","978-80-02-02210-7 (CD-ROM)"]},"publication":"Proceedings 19th International Congress of Chemical and Process Engineering","date_created":"2020-06-04T13:18:51Z","type":"conference_editor_article","language":[{"iso":"eng"}],"_id":"2815"},{"date_created":"2020-06-05T14:12:21Z","type":"patent","date_updated":"2023-03-15T13:49:43Z","user_id":"45666","ipn":"WO002010034428A2","alternative_title":["Method for reducing deposits during the cultivation of organisms"],"ipc":"C12N 5/00","_id":"2873","extern":"1","title":"Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen","application_number":"2009006722 ","citation":{"ufg":"Brod, Helmut et. al. (2010): Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","mla":"Brod, Helmut, et al. Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen. 2010.","bjps":"Brod H, Frahm B and Kauling J (2010) Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen.","havard":"H. Brod, B. Frahm, J. Kauling, Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen, (2010).","van":"Brod H, Frahm B, Kauling J. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen. 2010.","chicago":"Brod, Helmut, Björn Frahm, and Jörg Kauling. “Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen,” 2010.","apa":"Brod, H., Frahm, B., & Kauling, J. (2010). Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","chicago-de":"Brod, Helmut, Björn Frahm und Jörg Kauling. 2010. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.","din1505-2-1":"Brod, Helmut ; Frahm, Björn ; Kauling, Jörg: Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen (2010)","short":"H. Brod, B. Frahm, J. Kauling, (2010).","ama":"Brod H, Frahm B, Kauling J. Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen. 2010.","ieee":"H. Brod, B. Frahm, and J. Kauling, “Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.” 2010."},"department":[{"_id":"DEP4021"}],"year":2010,"author":[{"last_name":"Brod","first_name":"Helmut","full_name":"Brod, Helmut"},{"full_name":"Frahm, Björn","id":"45666","first_name":"Björn","last_name":"Frahm"},{"first_name":"Jörg","full_name":"Kauling, Jörg","last_name":"Kauling"}],"application_date":"2009-09-17","abstract":[{"lang":"ger","text":"Die Erfindung betrifft ein Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen, insbesondere von Zellkulturen, welche zur Agglomeration bzw. Anhaftung an den Bioreaktor und seine Elemente neigen, oder bei denen Zelldebris oder Substanzen leicht agglomerieren bzw. anhaften."},{"lang":"eng","text":"The invention relates to a method for reducing deposits during the cultivation of organisms, particularly cell cultures, which tend to agglomerate or adhere to the bioreactor and the elements thereof, or in which cell debris or substances easily agglomerate or adhere. "}],"page":"26","status":"public","publication_date":"2010-04-01"},{"application_number":"2009008733 ","citation":{"chicago":"Brod, Helmut, Björn Frahm, Marc Jenne, and Jörg Kauling. “Bioreaktor,” 2010.","ieee":"H. Brod, B. Frahm, M. Jenne, and J. Kauling, “Bioreaktor.” 2010.","apa":"Brod, H., Frahm, B., Jenne, M., & Kauling, J. (2010). Bioreaktor.","mla":"Brod, Helmut, et al. Bioreaktor. 2010.","havard":"H. Brod, B. Frahm, M. Jenne, J. Kauling, Bioreaktor, (2010).","bjps":"Brod H et al. (2010) Bioreaktor.","ufg":"Brod, Helmut et. al. (2010): Bioreaktor.","ama":"Brod H, Frahm B, Jenne M, Kauling J. Bioreaktor. 2010.","van":"Brod H, Frahm B, Jenne M, Kauling J. Bioreaktor. 2010.","din1505-2-1":"Brod, Helmut ; Frahm, Björn ; Jenne, Marc ; Kauling, Jörg: Bioreaktor (2010)","chicago-de":"Brod, Helmut, Björn Frahm, Marc Jenne und Jörg Kauling. 2010. Bioreaktor.","short":"H. Brod, B. Frahm, M. Jenne, J. Kauling, (2010)."},"extern":"1","title":"Bioreaktor","page":"27","status":"public","publication_date":"2010-06-24","department":[{"_id":"DEP4021"}],"author":[{"full_name":"Brod, Helmut","first_name":"Helmut","last_name":"Brod"},{"first_name":"Björn","last_name":"Frahm","id":"45666","full_name":"Frahm, Björn"},{"first_name":"Marc","full_name":"Jenne, Marc","last_name":"Jenne"},{"full_name":"Kauling, Jörg","first_name":"Jörg","last_name":"Kauling"}],"year":2010,"abstract":[{"lang":"ger","text":"Die Erfindung betrifft einen Bioreaktor, die Verwendung des Bioreaktors zur Kultivierung von Mikroorganismen oder Zellkulturen sowie ein Verfahren zur Kultivierung von Mikroorganismen oder Zellkulturen. "},{"lang":"eng","text":"The invention relates to a bioreactor, to the use of the bioreactor for culturing microorganisms or cell cultures, and also to a method for culturing microorganisms or cell cultures. "}],"application_date":"2009-12-08","date_updated":"2023-03-15T13:49:43Z","user_id":"45666","date_created":"2020-06-05T14:17:50Z","type":"patent","_id":"2874","ipn":"WO002010069492A1","ipc":"C12M 1/04","alternative_title":["Mikrogespargter Air-Lift-Bioreaktor für die Zellkultur"]},{"application_number":"2010000124 ","citation":{"chicago":"Frahm, Björn, Jörg Kauling, Andre Pütz, and Markus Schindler. “Begasungssystem,” 2010.","apa":"Frahm, B., Kauling, J., Pütz, A., & Schindler, M. (2010). Begasungssystem.","ieee":"B. Frahm, J. Kauling, A. Pütz, and M. Schindler, “Begasungssystem.” 2010.","ufg":"Frahm, Björn et. al. (2010): Begasungssystem.","bjps":"Frahm B et al. (2010) Begasungssystem.","mla":"Frahm, Björn, et al. Begasungssystem. 2010.","havard":"B. Frahm, J. Kauling, A. Pütz, M. Schindler, Begasungssystem, (2010).","van":"Frahm B, Kauling J, Pütz A, Schindler M. Begasungssystem. 2010.","ama":"Frahm B, Kauling J, Pütz A, Schindler M. Begasungssystem. 2010.","din1505-2-1":"Frahm, Björn ; Kauling, Jörg ; Pütz, Andre ; Schindler, Markus: Begasungssystem (2010)","chicago-de":"Frahm, Björn, Jörg Kauling, Andre Pütz und Markus Schindler. 2010. Begasungssystem.","short":"B. Frahm, J. Kauling, A. Pütz, M. Schindler, (2010)."},"title":"Begasungssystem","extern":"1","status":"public","page":"35","publication_date":"2010-07-09","year":2010,"author":[{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"},{"last_name":"Kauling","full_name":"Kauling, Jörg","first_name":"Jörg"},{"last_name":"Pütz","first_name":"Andre","full_name":"Pütz, Andre"},{"first_name":"Markus","last_name":"Schindler","full_name":"Schindler, Markus"}],"department":[{"_id":"DEP4021"}],"application_date":"2010-01-13","abstract":[{"lang":"ger","text":"Gegenstand der Erfindung ist ein neuartiges Begasungssystem, das insbesondere aber nicht ausschließlich in der Biotechnologie zur Versorgung von Zellen oder Mikroorganismen mit Sauerstoff einsetzbar ist. Das Begasungssystem umfasst eine Blasensäule und einen Verteiler. In dem Gefäß befindet sich ferner ein flüssiges Medium, das mit Gas versorgt werden soll. Es wird ein Vektor als Transportmittel für das Gas eingesetzt. Das Gas wird in die Blasensäule eingetragen und hier von dem Vektor aufgenommen. Der Vektor wird in Tropfenform über den Verteiler auf die Flüssigkeitsoberfläche aufgetragen, sinkt in dem Medium nach unten und gibt einen Teil des aufgenommenen Gases an das Medium ab. Am Boden des Gefäßes befindet sich eine Sammelvorrichtung, in der die Vektortropfen koaleszieren und wieder in die Blasensäule gelangen. Gegenstand der Erfindung ist weiterhin ein Bioreaktor umfassend das neuartige Begasungssystem. Gegenstand der Erfindung ist ferner ein Verfahren zur Begasung eines flüssigen Mediums, vorzugsweise einer Zellen oder Mikroorganismen enthaltenden wässrigen Suspension. "},{"text":" The invention relates to a novel gassing system that can be used particularly but not exclusively in biotechnology for supplying oxygen to cells or microorganisms. The gassing system comprises a bubble column and a distributor. There is furthermore a fluid medium in the tank that is to be supplied with gas. A vector is used as a transport means for the gas. The gas is incorporated into the bubble column and taken up by the vector here. The vector is applied to the fluid surface in droplet form via the distributor, sinks down into the medium and releases a portion of the absorbed gas to the medium. There is a collection device on the floor of the tank wherein the vector drops coalesce and enter the bubble column again. The invention furthermore relates to a bioreactor comprising the novel gassing system. The invention furthermore relates to a method for gassing a fluid medium, preferably an aqueous suspension comprising cells or microorganisms. ","lang":"eng"}],"user_id":"45666","date_updated":"2023-03-15T13:49:43Z","type":"patent","date_created":"2020-06-05T14:22:30Z","_id":"2875","ipn":"WO002010083956A2","alternative_title":["Gassing System"],"ipc":"C12M 1/04 "},{"_id":"2892","language":[{"iso":"eng"}],"user_id":"45666","date_updated":"2023-03-15T13:49:43Z","type":"conference_speech","date_created":"2020-06-08T14:12:17Z","status":"public","author":[{"first_name":"Björn","id":"45666","full_name":"Frahm, Björn","last_name":"Frahm"},{"first_name":"Helmut","last_name":"Brod","full_name":"Brod, Helmut"}],"year":2010,"department":[{"_id":"DEP4021"}],"conference":{"location":"Boston, USA","name":"6th annual Optimizing Cell Culture Technology-Meeting as part of The Bioprocessing Summit - Practical Solutions for Today’s Laboratory Challenges","start_date":"2010-08-23","end_date":"2010-08-24"},"citation":{"chicago":"Frahm, Björn, and Helmut Brod. 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Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, 2010.","din1505-2-1":"Dercks, B. ; Frahm, Björn ; Grünewald, M. ; Kenig, E. ; Lautenschleger, A. ; Gorak, A. ; Schmidt, P. ; Sudhoff, D. ; u. a.: Intensified absorption and distillation devices for modular chemical production processes, 2010","chicago-de":"Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler und R. Zecirovic. 2010. Intensified absorption and distillation devices for modular chemical production processes.","van":"Dercks B, Frahm B, Grünewald M, Kenig E, Lautenschleger A, Gorak A, et al. Intensified absorption and distillation devices for modular chemical production processes. 2010.","ufg":"Dercks, B. et. al. (2010): Intensified absorption and distillation devices for modular chemical production processes.","havard":"B. 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Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, 2010."},"publication_status":"published","author":[{"full_name":"Dercks, B.","first_name":"B.","last_name":"Dercks"},{"id":"45666","first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn"},{"last_name":"Grünewald","full_name":"Grünewald, M.","first_name":"M."},{"last_name":"Kenig","full_name":"Kenig, E.","first_name":"E."},{"first_name":"A.","full_name":"Lautenschleger, A.","last_name":"Lautenschleger"},{"first_name":"A.","last_name":"Gorak","full_name":"Gorak, A."},{"first_name":"P.","last_name":"Schmidt","full_name":"Schmidt, P."},{"full_name":"Sudhoff, D.","last_name":"Sudhoff","first_name":"D."},{"first_name":"S.","full_name":"Ressler, S.","last_name":"Ressler"},{"full_name":"Zecirovic, R.","first_name":"R.","last_name":"Zecirovic"}],"year":2010,"department":[{"_id":"DEP4021"}],"conference":{"location":"Prague, Czech Republic","name":"19th International Congress of Chemical and Process Engineering, CHISA ","start_date":"2010-08-28","end_date":"2010-09-01"},"status":"public"},{"publication_status":"published","department":[{"_id":"DEP4021"}],"issue":"1","publisher":"Springer","quality_controlled":"1","type":"scientific_journal_article","user_id":"45666","intvolume":" 59","_id":"2349","doi":"10.1007/s10616-009-9189-9","title":"Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration","extern":"1","citation":{"ieee":"B. Frahm, H. Brod, and U. Langer, “Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration,” Cytotechnology, vol. 59, no. 1, pp. 17–30, 2009.","ama":"Frahm B, Brod H, Langer U. Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology. 2009;59(1):17-30. doi:10.1007/s10616-009-9189-9","chicago-de":"Frahm, Björn, Helmut Brod und Uwe Langer. 2009. Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology 59, Nr. 1: 17–30. doi:10.1007/s10616-009-9189-9, .","din1505-2-1":"Frahm, Björn ; Brod, Helmut ; Langer, Uwe: Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. In: Cytotechnology Bd. 59, Springer (2009), Nr. 1, S. 17–30","short":"B. Frahm, H. Brod, U. Langer, Cytotechnology 59 (2009) 17–30.","chicago":"Frahm, Björn, Helmut Brod, and Uwe Langer. “Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration.” Cytotechnology 59, no. 1 (2009): 17–30. https://doi.org/10.1007/s10616-009-9189-9.","apa":"Frahm, B., Brod, H., & Langer, U. (2009). Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology, 59(1), 17–30. https://doi.org/10.1007/s10616-009-9189-9","bjps":"Frahm B, Brod H and Langer U (2009) Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration. Cytotechnology 59, 17–30.","mla":"Frahm, Björn, et al. “Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration.” Cytotechnology, vol. 59, no. 1, Springer, 2009, pp. 17–30, doi:10.1007/s10616-009-9189-9.","havard":"B. Frahm, H. Brod, U. 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Cytotechnology. 2009;59(1):17–30."},"volume":59,"year":2009,"author":[{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"},{"full_name":"Brod, Helmut","first_name":"Helmut","last_name":"Brod"},{"last_name":"Langer","first_name":"Uwe","full_name":"Langer, Uwe"}],"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677146/"}],"status":"public","page":"17-30","publication_identifier":{"eissn":["1573-0778"],"issn":["0920-9069"]},"publication":"Cytotechnology","date_created":"2020-05-15T10:17:11Z","date_updated":"2023-03-15T13:49:39Z","oa":"1","language":[{"iso":"eng"}]},{"extern":"1","title":"Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen","citation":{"chicago-de":"Braun, Arndt, Helmut Brod, Björn Frahm, Marc Jenne, Jörg Kauling und Stephan Kirchner. 2009. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.","din1505-2-1":"Braun, Arndt ; Brod, Helmut ; Frahm, Björn ; Jenne, Marc ; Kauling, Jörg ; Kirchner, Stephan: Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen (2009)","short":"A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, (2009).","ufg":"Braun, Arndt et. al. (2009): Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.","havard":"A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen, (2009).","mla":"Braun, Arndt, et al. Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen. 2009.","bjps":"Braun A et al. (2009) Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen.","van":"Braun A, Brod H, Frahm B, Jenne M, Kauling J, Kirchner S. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen. 2009.","ama":"Braun A, Brod H, Frahm B, Jenne M, Kauling J, Kirchner S. Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen. 2009.","chicago":"Braun, Arndt, Helmut Brod, Björn Frahm, Marc Jenne, Jörg Kauling, and Stephan Kirchner. “Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen,” 2009.","apa":"Braun, A., Brod, H., Frahm, B., Jenne, M., Kauling, J., & Kirchner, S. (2009). Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.","ieee":"A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, and S. Kirchner, “Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.” 2009."},"application_number":"2009004200 ","application_date":"2009-06-10","abstract":[{"text":"Die Erfindung betrifft eine Vorrichtung und ein Verfahren zur Rückhaltung und Rückführung von Zellen in einem kontinuierlich oder absatzweise durchströmten Gefäß. Ferner betrifft die Erfindung ein Verfahren zur Herstellung einer Vorrichtung, mit dem Zellen in einem kontinuierlich oder absatzweise durchströmten Gefäß zurückgehalten und zurückgeführt werden können. ","lang":"ger"},{"text":"The invention relates to an apparatus and a method for retaining and recirculating cells in a continuous-flow or batch-flow vessel. The invention further relates to a method for producing an apparatus which allows cells to be retained and recirculated in a continuous-flow or batch-flow vessel.","lang":"eng"}],"department":[{"_id":"DEP4021"}],"year":2009,"author":[{"first_name":"Arndt","last_name":"Braun","full_name":"Braun, Arndt"},{"last_name":"Brod","full_name":"Brod, Helmut","first_name":"Helmut"},{"last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn","id":"45666"},{"last_name":"Jenne","first_name":"Marc","full_name":"Jenne, Marc"},{"last_name":"Kauling","first_name":"Jörg","full_name":"Kauling, Jörg"},{"first_name":"Stephan","last_name":"Kirchner","full_name":"Kirchner, Stephan"}],"publication_date":"200-12-23","page":"35","status":"public","type":"patent","date_created":"2020-06-05T14:07:35Z","date_updated":"2023-03-15T13:49:43Z","user_id":"45666","ipc":"C12M 1/08","alternative_title":["Device for retaining and recirculating cells in a continuous-flow or batch-flow vessel, comprises channels, means for fumigation of external surfaces and/or spaces between the channels, and a generating mean"],"ipn":"WO002009152990A2 ","_id":"2872"},{"title":"Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)","extern":"1","citation":{"short":"B. 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Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor.; 2009."},"publication_status":"published","_id":"2971","language":[{"iso":"eng"}],"type":"conference_poster","date_created":"2020-06-18T14:25:53Z","user_id":"45666","date_updated":"2023-03-15T13:49:44Z"},{"status":"public","department":[{"_id":"DEP4021"}],"conference":{"start_date":"2008-12-05","location":"Leverkusen, Germany","name":"Technology Colloquium, BayKomm"},"author":[{"last_name":"Brod","full_name":"Brod, H.","first_name":"H."},{"last_name":"Kauling","full_name":"Kauling, J.","first_name":"J."},{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"},{"full_name":"Jenne, M.","first_name":"M.","last_name":"Jenne"},{"first_name":"U.","last_name":"Langer","full_name":"Langer, U."},{"last_name":"Bödeker","first_name":"B.","full_name":"Bödeker, B."}],"year":2008,"citation":{"chicago":"Brod, H., J. Kauling, Björn Frahm, M. Jenne, U. 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Pörtner, B. Frahm, P. Lane, A. Munack, K. Kühn, V.C. Hass, Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller, Springer, Dordrecht, 2007.","din1505-2-1":"Pörtner, Ralf ; Frahm, Björn ; Lane, Paul ; Munack, Axel ; Kühn, Kathrin ; Hass, Volker C.: Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller, ESACT Proceedings. Bd. 3. Dordrecht : Springer, 2007","chicago-de":"Pörtner, Ralf, Björn Frahm, Paul Lane, Axel Munack, Kathrin Kühn und Volker C. Hass. 2007. Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller. Cell Technology for Cell Products. Bd. 3. ESACT Proceedings. Dordrecht: Springer. doi:10.1007/978-1-4020-5476-1_84, .","ieee":"R. Pörtner, B. Frahm, P. Lane, A. Munack, K. Kühn, and V. C. Hass, Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller, vol. 3. 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Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller. Cell Technology for Cell Products. Dordrecht: Springer; 2007. (ESACT Proceedings; vol. 3).","havard":"R. Pörtner, B. Frahm, P. Lane, A. Munack, K. Kühn, V.C. Hass, Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller, Springer, Dordrecht, 2007.","bjps":"Pörtner R et al. (2007) Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller. Dordrecht: Springer.","mla":"Pörtner, Ralf, et al. “Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller.” Cell Technology for Cell Products, vol. 3, Springer, 2007, pp. 497–501, doi:10.1007/978-1-4020-5476-1_84.","ufg":"Pörtner, Ralf et. al. (2007): Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller (=ESACT Proceedings 3), Dordrecht."},"series_title":"ESACT Proceedings","extern":"1","title":"Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller","language":[{"iso":"eng"}],"place":"Dordrecht","doi":"10.1007/978-1-4020-5476-1_84","_id":"2814","date_updated":"2023-03-15T13:49:43Z","user_id":"45666","type":"conference_editor_article","date_created":"2020-06-04T13:02:21Z","publication_identifier":{"isbn":["978-1-402-05475-4"]},"publication":"Cell Technology for Cell Products"},{"status":"public","publication_date":"2007-08-30","year":2007,"author":[{"full_name":"Brod, Helmut","first_name":"Helmut","last_name":"Brod"},{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"},{"full_name":"Kauling, Jörg","first_name":"Jörg","last_name":"Kauling"},{"first_name":"Reinhold","last_name":"Rose","full_name":"Rose, Reinhold"}],"main_file_link":[{"url":"https://depatisnet.dpma.de/DepatisNet/depatisnet?action=bibdat&docid=DE102006008687A1","open_access":"1"}],"department":[{"_id":"DEP4021"}],"application_date":"2006-02-24","abstract":[{"lang":"eng","text":"The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude and the equivalent number of revolutions. The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude, the equivalent number of revolutions, acceleration of the membrane surface, the delay of the membrane surface, the interruption of the movement or discontinuity. The course of motion is not restricted to recurring samples. The material transfer is increased by mounting of immovable current interfering elements. The disturb of the current forms by the rotatingly oscillating movement of the membrane surfaces. The supply of the membrane surface is undertaken with the help of flexible hoses or turning seals for the supply and discharge of gas. The membrane surface is used for the production of micro-bubbles or gas bubbles in the liquid. Rotor arms rotate in one of the rotation directions curved around the drive shaft. An independent claim is included for a device for gassing of liquid for cell cultures. "},{"lang":"ger","text":"Die Erfindung betrifft ein Verfahren und eine Vorrichtung zur blasenfreien Begasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. "}],"application_number":" \t102006008687 ","citation":{"ama":"Brod H, Frahm B, Kauling J, Rose R. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component. 2007.","ieee":"H. Brod, B. Frahm, J. Kauling, and R. Rose, “Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.” 2007.","din1505-2-1":"Brod, Helmut ; Frahm, Björn ; Kauling, Jörg ; Rose, Reinhold: Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component (2007)","chicago-de":"Brod, Helmut, Björn Frahm, Jörg Kauling und Reinhold Rose. 2007. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.","short":"H. Brod, B. Frahm, J. Kauling, R. Rose, (2007).","havard":"H. Brod, B. Frahm, J. Kauling, R. Rose, Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component, (2007).","mla":"Brod, Helmut, et al. Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component. 2007.","bjps":"Brod H et al. (2007) Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component.","ufg":"Brod, Helmut et. al. (2007): Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.","van":"Brod H, Frahm B, Kauling J, Rose R. Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component. 2007.","chicago":"Brod, Helmut, Björn Frahm, Jörg Kauling, and Reinhold Rose. “Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component,” 2007.","apa":"Brod, H., Frahm, B., Kauling, J., & Rose, R. (2007). Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component."},"title":"Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component","extern":"1","_id":"2870","oa":"1","ipn":"DE102006008687A1","alternative_title":["Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten"],"ipc":"C12M 1/04 ","user_id":"45666","date_updated":"2023-03-15T13:49:43Z","type":"patent","date_created":"2020-06-05T13:41:13Z"},{"user_id":"45666","date_updated":"2023-03-15T13:49:43Z","type":"patent","date_created":"2020-06-05T13:57:51Z","_id":"2871","ipn":"WO002007121958A1","alternative_title":["One-trip plastic reactor for bio-technological and pharmaceutical production applications rotates and oscillates on a vertical shaft"],"ipc":"B01J 19/28","application_number":"2007003521 ","citation":{"ieee":"H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, and S. Schmidt, “Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.” 2007.","ama":"Brod H, Frahm B, Kauling J, Poggel M, Rose R, Schmidt S. Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. 2007.","din1505-2-1":"Brod, Helmut ; Frahm, Björn ; Kauling, Jörg ; Poggel, Martin ; Rose, Reinhold ; Schmidt, Sebastian : Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen (2007)","chicago-de":"Brod, Helmut, Björn Frahm, Jörg Kauling, Martin Poggel, Reinhold Rose und Sebastian Schmidt. 2007. Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.","short":"H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, S. Schmidt, (2007).","chicago":"Brod, Helmut, Björn Frahm, Jörg Kauling, Martin Poggel, Reinhold Rose, and Sebastian Schmidt. “Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen,” 2007.","apa":"Brod, H., Frahm, B., Kauling, J., Poggel, M., Rose, R., & Schmidt, S. (2007). Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.","havard":"H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, S. Schmidt, Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen, (2007).","bjps":"Brod H et al. (2007) Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen.","mla":"Brod, Helmut, et al. 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Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen. 2007."},"title":"Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen","extern":"1","status":"public","page":"56","publication_date":"2007-11-01","year":2007,"author":[{"full_name":"Brod, Helmut","first_name":"Helmut","last_name":"Brod"},{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"},{"last_name":"Kauling","full_name":"Kauling, Jörg","first_name":"Jörg"},{"first_name":"Martin","full_name":"Poggel, Martin","last_name":"Poggel"},{"first_name":"Reinhold","full_name":"Rose, Reinhold","last_name":"Rose"},{"full_name":"Schmidt, Sebastian ","last_name":"Schmidt","first_name":"Sebastian "}],"department":[{"_id":"DEP4021"}],"application_date":"2007-04-23","abstract":[{"text":"Gegenstand der Erfindung ist ein um seine ortsfeste, bevorzugt vertikale Achse oszillatorischrotierend angetriebener Reaktor für bevorzugt biotechnologische und pharmazeutische Anwendungen. Mit seinen prozessintensivierenden Eigenschaften für das Mischen, das Suspendieren, den Gasstofftransport, die Wärmeübertragung, die Bestrahlung und die Partikelrückhaltung wird die Anwendbarkeit im großtechnischen Maßstab gewährleistet. Der ohne Wellenabdichtung auskommende Reaktor erlaubt eine steriltechnisch besonders robuste Produktion unter Verzicht auf eine Reinigung und Reinigungsvalidierung erfordert, wenn der Reaktor als Einwegreaktor ausgeführt ist. ","lang":"ger"},{"lang":"eng","text":"The subject matter of the invention is a reactor, driven about its fixed, preferably vertical, axis in an oscillatory/rotating manner, for preferably biotechnological and pharmaceutical applications. With its process-intensifying properties for mixing, suspending, gas transport, heat transfer, irradiation and particle retention, the applicability is ensured on a commercial scale. The reactor, which does not need a shaft seal, permits especially robust production with respect to sterile requirements while dispensing with cleaning and cleaning validation if the reactor is designed as a one-way reactor. "}]},{"date_updated":"2023-03-15T13:49:43Z","user_id":"45666","type":"conference_speech","date_created":"2020-06-10T13:47:31Z","language":[{"iso":"ger"}],"_id":"2909","citation":{"apa":"Brod, H., Frahm, B., & Kauling, J. (2007). Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. Presented at the GVC Fachausschuss Mischvorgänge, Würzburg, Germany.","chicago":"Brod, Helmut, Björn Frahm, and Jörg Kauling. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.","van":"Brod H, Frahm B, Kauling J. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. 2007.","ufg":"Brod, Helmut et. al. 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(2003): Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis, in: Bioprocess and Biosystems Engineering 26 (1), S. 1–10."},"extern":"1","title":"Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis","page":"1-10","status":"public","main_file_link":[{"url":"https://link.springer.com/article/10.1007/s00449-003-0335-z","open_access":"1"}],"author":[{"last_name":"Frahm","first_name":"Björn","id":"45666","full_name":"Frahm, Björn"},{"first_name":"P.","full_name":"Lane, P.","last_name":"Lane"},{"full_name":"Märkl, H.","last_name":"Märkl","first_name":"H."},{"first_name":"R.","full_name":"Pörtner, R.","last_name":"Pörtner"}],"year":2003},{"title":"Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen","publication_status":"published","citation":{"ama":"Frahm B. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH; 2003.","ieee":"B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH, 2003.","chicago-de":"Frahm, Björn. 2003. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH.","din1505-2-1":"Frahm, Björn: Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt : Books on Demand GmbH, 2003","short":"B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003.","bjps":"Frahm B (2003) Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH.","havard":"B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003.","mla":"Frahm, Björn. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Books on Demand GmbH, 2003.","ufg":"Frahm, Björn (2003): Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Norderstedt.","van":"Frahm B. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH; 2003. 120 p.","chicago":"Frahm, Björn. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH, 2003.","apa":"Frahm, B. (2003). Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH."},"abstract":[{"lang":"ger","text":"Die wirtschaftlich immer mehr an Bedeutung gewinnende Kultivierung tierischer Zelllinien umfasst zahlreiche Anwendungen in der Pharmaherstellung und Medizintechnik. Eine Vielzahl der Produkte (Diagnostika, Impfstoffe, Therapeutika) wird in Fed-Batch-Prozessen hergestellt. Für die verbesserte Steuerung von derartigen Fed-Batch-Prozessen stellt der Autor eine adaptive, modellgestützte Steuerung vor. Anwendungsbeispiele veranschaulichen das Potential und die Flexibilität der Steuerung und ihre Universalität bezüglich verschiedener Kultivierungssysteme und Zelllinien. \r\n\r\nDa auch die gelöst-CO2-Konzentration und die Atmungsaktivität der Zellen zunehmend Bedeutung in der Prozessführung erlangen, stellt dieses Buch weiterhin die entwickelte Erfassung dieser Größen per Abgasanalytik und Modellierung des Kohlendioxidtransfers vor."}],"department":[{"_id":"DEP4021"}],"author":[{"last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn","id":"45666"}],"year":2003,"publisher":"Books on Demand GmbH","page":"120","status":"public","type":"dissertation","date_created":"2020-05-19T14:44:50Z","publication_identifier":{"isbn":[" \t978-3-8334-0111-4 "]},"date_updated":"2023-03-15T13:49:39Z","user_id":"45666","_id":"2393","language":[{"iso":"ger"}],"keyword":["Tierzelle","Suspensionskultur","Prozesssteuerung"],"place":"Norderstedt"},{"publication_status":"published","citation":{"van":"Frahm B, Müller-Landré B, Wiggers de Almeida G, Singer M, Rausch M, Lane P, et al. 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Munack, V.C. Hass, R. Pörtner, Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control, Inst. für Bioprozess- und Analysenmesstechnik , Heiligenstadt, 2003.","ufg":"Frahm, Björn et. al. (2003): Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control, Heiligenstadt.","apa":"Frahm, B., Müller-Landré, B., Wiggers de Almeida, G., Singer, M., Rausch, M., Lane, P., … Pörtner, R. (2003). Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. (D. Beckmann & Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld), Eds.), Technische Systeme für Biotechnologie und Umwelt (pp. 503–509). Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik .","chicago":"Frahm, Björn, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V. C. Hass, and R. Pörtner. Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control. 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Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik .","din1505-2-1":"Frahm, Björn ; Müller-Landré, B. ; Wiggers de Almeida, G. ; Singer, M. ; Rausch, M. ; Lane, P. ; Munack, A. ; Hass, V. C. ; u. a. ; Beckmann, D. ; Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld) (Hrsg.): Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. Heiligenstadt : Inst. für Bioprozess- und Analysenmesstechnik , 2003","ama":"Frahm B, Müller-Landré B, Wiggers de Almeida G, et al. Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control. (Beckmann D, Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld), eds.). Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik ; 2003:503-509.","ieee":"B. Frahm et al., Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. 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Munack. 2000. Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus.","short":"M. Hoffmann, B. Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V.C. Hass, A. Munack, Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus, 2000.","chicago":"Hoffmann, M., Björn Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V. C. Hass, and A. Munack. Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus, 2000.","apa":"Hoffmann, M., Frahm, B., Schwabe, J.-O., Lane, P., Pörtner, R., Hass, V. C., & Munack, A. (2000). Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. Presented at the 10. Heiligenstädter Kolloquium, Technische Systeme für Biotechnologie und Umwelt, Heilbad Heiligenstadt, Germany.","bjps":"Hoffmann M et al. (2000) Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. .","mla":"Hoffmann, M., et al. Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. 2000.","havard":"M. Hoffmann, B. Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V.C. Hass, A. Munack, Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus, 2000.","ufg":"Hoffmann, M. et. al. (2000): Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus.","van":"Hoffmann M, Frahm B, Schwabe J-O, Lane P, Pörtner R, Hass VC, et al. Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. 2000."},"publication_status":"published"}]