@misc{13233,
  abstract     = {{Atranones are secondary metabolites produced by Stachybotrys chartarum, a mold frequently found in water-damaged indoor environments. In contrast to the well-characterized and highly toxic macrocyclic trichothecenes, atranones have received relatively limited scientific attention. Approximately 60% of S. chartarum isolates from indoor environments produce atranones, while 40% form macrocyclic trichothecenes. No strain has been shown to produce both, indicating that the biosynthetic pathways for these two mycotoxin classes are mutually exclusive. Atranones are dolabellane-like diterpenoids synthesized from geranylgeranyl pyrophosphate through multiple enzymatic steps encoded by a specific core gene cluster. While the genetic structure of this cluster has been elucidated, its regulatory mechanisms remain poorly understood. Notably, although atranone-producing S. chartarum strains have been isolated from indoor settings, no study has yet confirmed the actual production of atranones in indoor environments, leaving the question of real-world exposure unresolved. Experimental studies in cell cultures and animal models indicate that atranones possess pro-inflammatory and cytotoxic properties, including the induction of apoptosis and cell cycle arrest. Atranone Q has demonstrated antitumor activity against osteosarcoma cells in vitro, and more recently identified derivatives such as stachatranone and stachybatranone have shown preliminary cardioprotective effects under ischemic conditions. However, these pharmacological effects remain exploratory and require further validation in in vivo models. Major knowledge gaps concern the environmental triggers for atranone biosynthesis, their regulation, actual presence in built environments, and potential health risks. These areas represent key priorities for future research. }},
  author       = {{Dabisch-Ruthe, Mareike and Pfannebecker, Jens and Straubinger, Reinhard K. and Ebel, Frank and Ulrich, Sebastian}},
  booktitle    = {{Mycotoxin Research}},
  issn         = {{1867-1632}},
  keywords     = {{Atranone, Secondary metabolite, Stachybotrys, Stachatranone, Stachybatranone}},
  publisher    = {{Springer}},
  title        = {{{Atranone-an underestimated secondary metabolite?}}},
  doi          = {{10.1007/s12550-025-00609-x}},
  year         = {{2025}},
}

@misc{12787,
  abstract     = {{Vapor phase hydrogen peroxide (H2O2) can be utilized to inactivate murine norovirus (MNV), a surrogate of human norovirus, on surface areas. However, vapor phase H2O2 inactivation of virus on fruits and vegetables has not been characterized. In this study, MNV was used to determine whether vaporized H2O2 inactivates virus on surfaces of various fruits and vegetables (apples, blueberries, cucumbers, and strawberries). The effect of vapor phase H2O2 decontamination was investigated with two application systems. Plaque assays were performed after virus recovery from untreated and treated fresh produce to compare the quantity of infective MNV. The Mann-Whitney U test was applied to the test results to evaluate the virus titer reductions of treated food samples, with significance set at P <= 0.05. The infective MNV populations were significantly reduced on smooth surfaces by 4.3 log PFU (apples, P < 0.00001) and 4 log PFU or below the detection limit (blueberries, P = 0.0074) by treatment with vapor phase H2O2 (60 min, maximum of 214 ppm of H2O2). Similar treatments of artificially contaminated cucumbers resulted in a virus titer reduction of 1.9 log PFU. Treatment of inoculated strawberries resulted in 0.1and 2.8-log reductions of MNV. However, MNV reduction rates on cucumbers (P = 0.3809) and strawberries (P = 0,7414) were not significant. Triangle tests and color measurements of untreated and treated apples, cucumbers, blueberries, and strawberries revealed no differences in color and consistency after H2O2 treatment. No increase of the H2O2 concentration in treated fruits and vegetables compared with untreated produce was observed. This study reveals for the first time the conditions under which vapor phase H2O2 inactivates MNV on selected fresh fruit and vegetable surfaces.}},
  author       = {{Becker, Barbara and Dabisch-Ruthe, Mareike and Pfannebecker, Jens}},
  booktitle    = {{  Journal of food protection }},
  issn         = {{1944-9097}},
  keywords     = {{Fruits, Inactivation, Murine norovirus, Vapor phase hydrogen peroxide, Vegetables}},
  number       = {{1}},
  pages        = {{45--51}},
  publisher    = {{IAFP}},
  title        = {{{Inactivation of Murine Norovirus on Fruit and Vegetable Surfaces by Vapor Phase Hydrogen Peroxide}}},
  doi          = {{10.4315/0362-028X.JFP-19-238}},
  volume       = {{83}},
  year         = {{2020}},
}

@misc{12989,
  author       = {{Dabisch-Ruthe, Mareike and Weinstock, Melanie and Pfannebecker, Jens and Becker, Barbara}},
  booktitle    = {{26th International ICFMH Conference - FoodMicro 2018}},
  location     = {{Berlin}},
  pages        = {{482}},
  title        = {{{Usage of cold hydrogen peroxide vapour for inactivation of murine norovirus on fruit and vegetable surfaces.}}},
  doi          = {{10.13140/RG.2.2.12883.08484}},
  year         = {{2018}},
}

@misc{12990,
  author       = {{Dabisch-Ruthe, Mareike and Weinstock, Melanie and Pfannebecker, Jens and Meyer, Sonja and Schwetka, Mona  and Becker, Barbara}},
  booktitle    = {{70th Annual Conference of the German Society of Hygiene and Microbiology}},
  isbn         = {{978-3-9816508-6-0}},
  location     = {{Bochum}},
  publisher    = {{Conventus Congressmanagement & Marketing GmbH }},
  title        = {{{Application of cold nebulized hydrogen peroxide for inactivation of murine norovirus, bacteria and bacteria spores on surfaces in food production.}}},
  doi          = {{10.13140/RG.2.2.22949.41447}},
  year         = {{2018}},
}

@book{2379,
  author       = {{Becker, Barbara and Pfannebecker, Jens}},
  isbn         = {{978-3-95468-388-8}},
  pages        = {{80}},
  publisher    = {{Behr`s Verlag}},
  title        = {{{Lebensmittelassoziierte Viren - Norovirus }}},
  year         = {{2016}},
}

@inproceedings{5350,
  author       = {{Pfannebecker, Jens and Becker, Barbara}},
  location     = {{Warschau}},
  title        = {{{Comparison of a molecular detection system prototype with the DIN EN ISO-methods for the detection of Listeria monocytogenes and Salmonella enteritidis}}},
  year         = {{2012}},
}

@inproceedings{5324,
  author       = {{Pfannebecker, Jens and Becker, Barbara}},
  booktitle    = {{ 	Fachsymposium Lebensmittelmikrobiologie, Damp (2011)}},
  location     = {{Damp}},
  title        = {{{Validierungsstudie eines kulturellen, mikrobiologischen Nachweissystems mit ausgewählten Rohstoffen  (Poster)}}},
  year         = {{2011}},
}

@inproceedings{5340,
  author       = {{Pfannebecker, Jens and Becker, Barbara}},
  location     = {{Damp}},
  title        = {{{Validierungsstudie eines kulturellen, mikrobiologischen Nachweissystems mit ausgewählten Rohstoffen}}},
  year         = {{2011}},
}