[{"user_id":"83781","type":"book_chapter","place":"Berlin, Heidelberg","_id":"13652","doi":"https://doi.org/10.1007/978-3-031-75698-6_5","publication_status":"published","series_title":"Advances in Biochemical Engineering/Biotechnology","publisher":"Springer ","quality_controlled":"1","department":[{"_id":"DEP4000"}],"abstract":[{"lang":"eng","text":"Modellbasierte Konzepte und Simulationstechniken in Kombination mit digitalen Werkzeugen erweisen sich als Schlüssel, um das volle Potenzial biopharmazeutischer Produktionsprozesse zu erschließen, die mehrere herausfordernde Entwicklungs- und Prozessschritte enthalten. Einer dieser Schritte ist der zeit- und kostenintensive Zellproliferationsprozess (auch als Seed Train bezeichnet), um die Zellzahl vom Auftauen der Zellen bis zum Produktionsmaßstab zu erhöhen. Herausforderungen wie komplexer Zellstoffwechsel, Chargen-zu-Chargen-Variationen, Variabilitäten im Zellverhalten und Einflüsse von Änderungen der Kultivierungsbedingungen erfordern adäquate digitale Lösungen, um Informationen über den aktuellen und zukünftigen Prozesszustand bereitzustellen und korrekte Prozessentscheidungen abzuleiten.\r\n\r\nZu diesem Zweck haben sich digitale Seed Train Zwillinge als effizient erwiesen, die das zeitabhängige Verhalten wichtiger Prozessvariablen basierend auf mathematischen Modellen, Strategien und Anpassungsverfahren digital darstellen.\r\n\r\nDieses Kapitel skizziert die Notwendigkeit der Digitalisierung von Seed Trains, den Aufbau eines digitalen Seed Train Zwillings, die Rolle der Parameterschätzung und verschiedene statistische Methoden in diesem Zusammenhang, die auf mehrere Probleme im Bereich der Bioprozessierung anwendbar sind. Die Ergebnisse einer Fallstudie werden vorgestellt, um einen Bayes’schen Ansatz zur Parameterschätzung und Vorhersage eines industriellen Zellkultur-Seed Trains für die Seed Train Digitalisierung zu veranschaulichen."}],"date_updated":"2026-04-08T12:46:45Z","editor":[{"first_name":"Christoph","full_name":"Herwig, Christoph","last_name":"Herwig"},{"full_name":"Pörtner, Ralf","last_name":"Pörtner","first_name":"Ralf"},{"first_name":"Johannes","full_name":"Möller, Johannes","last_name":"Möller"}],"publication_identifier":{"isbn":["978-3-031-75697-9"],"eisbn":["978-3-031-75698-6"]},"publication":"Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion","date_created":"2026-03-27T17:45:02Z","keyword":["Bayes","Digitaler Zwilling","Parameterabschätzung","Seed-Train","Unsicherheit"],"language":[{"iso":"ger"}],"citation":{"havard":"T. Hernández Rodriguez, B. Frahm, Digitale Seed Train Zwillinge und statistische Methoden, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, Springer , Berlin, Heidelberg, 2025: pp. 107–145.","mla":"Hernández Rodriguez, Tanja, and Björn Frahm. “Digitale Seed Train Zwillinge und statistische Methoden.” <i>Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion</i>, edited by Christoph Herwig et al., Springer , 2025, pp. 107–45, <a href=\"https://doi.org/10.1007/978-3-031-75698-6_5\">https://doi.org/10.1007/978-3-031-75698-6_5</a>.","bjps":"<b>Hernández Rodriguez T and Frahm B</b> (2025) Digitale Seed Train Zwillinge und statistische Methoden. In Herwig C, Pörtner R and Möller J (eds), <i>Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion</i>. Berlin, Heidelberg: Springer , pp. 107–145.","ufg":"<b>Hernández Rodriguez, Tanja/Frahm, Björn</b>: Digitale Seed Train Zwillinge und statistische Methoden, in: <i>Herwig, Christoph/Pörtner, Ralf/Möller, Johannes (Hgg.)</i>: Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, Berlin, Heidelberg 2025 (Advances in Biochemical Engineering/Biotechnology),  S. 107–145.","ama":"Hernández Rodriguez T, Frahm B. Digitale Seed Train Zwillinge und statistische Methoden. In: Herwig C, Pörtner R, Möller J, eds. <i>Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion</i>. Advances in Biochemical Engineering/Biotechnology. Springer ; 2025:107-145. doi:<a href=\"https://doi.org/10.1007/978-3-031-75698-6_5\">https://doi.org/10.1007/978-3-031-75698-6_5</a>","van":"Hernández Rodriguez T, Frahm B. Digitale Seed Train Zwillinge und statistische Methoden. In: Herwig C, Pörtner R, Möller J, editors. Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion. Berlin, Heidelberg: Springer ; 2025. p. 107–45. (Advances in Biochemical Engineering/Biotechnology).","chicago":"Hernández Rodriguez, Tanja, and Björn Frahm. “Digitale Seed Train Zwillinge und statistische Methoden.” In <i>Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion</i>, edited by Christoph Herwig, Ralf Pörtner, and Johannes Möller, 107–45. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer , 2025. <a href=\"https://doi.org/10.1007/978-3-031-75698-6_5\">https://doi.org/10.1007/978-3-031-75698-6_5</a>.","ieee":"T. Hernández Rodriguez and B. Frahm, “Digitale Seed Train Zwillinge und statistische Methoden,” in <i>Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion</i>, C. Herwig, R. Pörtner, and J. Möller, Eds. Berlin, Heidelberg: Springer , 2025, pp. 107–145. doi: <a href=\"https://doi.org/10.1007/978-3-031-75698-6_5\">https://doi.org/10.1007/978-3-031-75698-6_5</a>.","apa":"Hernández Rodriguez, T., &#38; Frahm, B. (2025). Digitale Seed Train Zwillinge und statistische Methoden. In C. Herwig, R. Pörtner, &#38; J. Möller (Eds.), <i>Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion</i> (pp. 107–145). Springer . <a href=\"https://doi.org/10.1007/978-3-031-75698-6_5\">https://doi.org/10.1007/978-3-031-75698-6_5</a>","chicago-de":"Hernández Rodriguez, Tanja und Björn Frahm. 2025. Digitale Seed Train Zwillinge und statistische Methoden. In: <i>Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion</i>, hg. von Christoph Herwig, Ralf Pörtner, und Johannes Möller, 107–145. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer . doi:<a href=\"https://doi.org/10.1007/978-3-031-75698-6_5\">https://doi.org/10.1007/978-3-031-75698-6_5</a>, .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Digitale Seed Train Zwillinge und statistische Methoden. In: <span style=\"font-variant:small-caps;\">Herwig, C.</span> ; <span style=\"font-variant:small-caps;\">Pörtner, R.</span> ; <span style=\"font-variant:small-caps;\">Möller, J.</span> (Hrsg.): <i>Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion</i>, <i>Advances in Biochemical Engineering/Biotechnology</i>. Berlin, Heidelberg : Springer , 2025, S. 107–145","short":"T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, Springer , Berlin, Heidelberg, 2025, pp. 107–145."},"title":"Digitale Seed Train Zwillinge und statistische Methoden","status":"public","page":"107-145","year":"2025","author":[{"first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja","id":"52466","last_name":"Hernández Rodriguez"},{"id":"45666","last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn"}]},{"author":[{"last_name":"Kosse","full_name":"Kosse, Pascal","first_name":"Pascal"},{"full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja","last_name":"Hernández Rodriguez","id":"52466"},{"id":"45666","first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn"},{"first_name":"Manfred","full_name":"Lübken, Manfred","last_name":"Lübken"},{"full_name":"Wichern, Marc","first_name":"Marc","last_name":"Wichern"}],"year":"2024","external_id":{"isi":["001169606600001"]},"page":"528-534","status":"public","title":"Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator","citation":{"ieee":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, and M. Wichern, “Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator,” <i>Chemie Ingenieur Technik</i>, vol. 96, no. 4, pp. 528–534, 2024, doi: <a href=\"https://doi.org/10.1002/cite.202300188\">10.1002/cite.202300188</a>.","ama":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. <i>Chemie Ingenieur Technik</i>. 2024;96(4):528-534. doi:<a href=\"https://doi.org/10.1002/cite.202300188\">10.1002/cite.202300188</a>","chicago":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken, and Marc Wichern. “Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.” <i>Chemie Ingenieur Technik</i> 96, no. 4 (2024): 528–34. <a href=\"https://doi.org/10.1002/cite.202300188\">https://doi.org/10.1002/cite.202300188</a>.","apa":"Kosse, P., Hernández Rodriguez, T., Frahm, B., Lübken, M., &#38; Wichern, M. (2024). Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. <i>Chemie Ingenieur Technik</i>, <i>96</i>(4), 528–534. <a href=\"https://doi.org/10.1002/cite.202300188\">https://doi.org/10.1002/cite.202300188</a>","havard":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, Chemie Ingenieur Technik. 96 (2024) 528–534.","mla":"Kosse, Pascal, et al. “Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.” <i>Chemie Ingenieur Technik</i>, vol. 96, no. 4, 2024, pp. 528–34, <a href=\"https://doi.org/10.1002/cite.202300188\">https://doi.org/10.1002/cite.202300188</a>.","bjps":"<b>Kosse P <i>et al.</i></b> (2024) Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. <i>Chemie Ingenieur Technik</i> <b>96</b>, 528–534.","ufg":"<b>Kosse, Pascal u. a.</b>: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, in: <i>Chemie Ingenieur Technik</i> 96 (2024), H. 4,  S. 528–534.","van":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik. 2024;96(4):528–34.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kosse, Pascal</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Lübken, Manfred</span> ; <span style=\"font-variant:small-caps;\">Wichern, Marc</span>: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. In: <i>Chemie Ingenieur Technik</i> Bd. 96. Weinheim, Wiley (2024), Nr. 4, S. 528–534","chicago-de":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken und Marc Wichern. 2024. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. <i>Chemie Ingenieur Technik</i> 96, Nr. 4: 528–534. doi:<a href=\"https://doi.org/10.1002/cite.202300188\">10.1002/cite.202300188</a>, .","short":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 96 (2024) 528–534."},"volume":96,"language":[{"iso":"eng"}],"keyword":["Anaerobic Digestion Model No. 1 (ADM1)","Anaerobic technology","pH simulation","Uncertainty assessment","Visual Water"],"date_created":"2025-01-29T13:49:16Z","publication_identifier":{"issn":["0009-286X"],"eissn":["1522-2640"]},"publication":"Chemie Ingenieur Technik","date_updated":"2025-06-25T12:42:09Z","department":[{"_id":"DEP4000"}],"issue":"4","abstract":[{"text":"In anaerobic technology, pH values are crucial for targeted volatile fatty acid production. While pH dynamics can be modeled using the Anaerobic Digestion Model No. 1 (ADM1), simulation results may be biased. To address this issue, the pH prediction routine of Visual Water, a specialized water chemistry simulator, was validated. Unlike ADM1, it accounts for ionic strength and activities while also providing an automated uncertainty analysis. The analysis revealed Visual Water simulations to better fit measured pH data from acidic solutions in a miniaturized stirred-tank reactor.","lang":"eng"}],"quality_controlled":"1","publisher":"Wiley","isi":"1","publication_status":"published","place":"Weinheim","doi":"10.1002/cite.202300188","_id":"12402","type":"scientific_journal_article","user_id":"83781","intvolume":"        96"},{"year":"2023","author":[{"full_name":"Hernández Rodriguez, Tanja","id":"52466","last_name":"Hernández Rodriguez","first_name":"Tanja"},{"orcid":"https://orcid.org/0000-0002-0502-8032","id":"68713","first_name":"Selina","full_name":"Ramm, Selina","last_name":"Ramm"},{"first_name":"Markus","full_name":"Lange-Hegermann, Markus","last_name":"Lange-Hegermann","id":"71761"},{"last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn","id":"45666"}],"department":[{"_id":"DEP4000"}],"conference":{"name":"14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology","location":"Berlin, Germany","end_date":"2023-09-21","start_date":"2023-09-17"},"status":"public","publisher":"DECHEMA e.V.","title":"A systematic, model-based workflow for risk-based decision making in upstream development","citation":{"van":"Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development. DECHEMA e.V.;","ufg":"<b>Hernández Rodriguez, Tanja u. a.</b>: A systematic, model-based workflow for risk-based decision making in upstream development, o. O. u. J. .","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (n.d.) <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>. DECHEMA e.V.","havard":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, DECHEMA e.V., n.d.","mla":"Hernández Rodriguez, Tanja, et al. <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>. DECHEMA e.V.","apa":"Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., &#38; Frahm, B. (n.d.). <i>A systematic, model-based workflow for risk-based decision making in upstream development</i>. 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Berlin, Germany. DECHEMA e.V.","chicago":"Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann, and Björn Frahm. <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>. DECHEMA e.V., n.d.","short":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, DECHEMA e.V., n.d.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Ramm, Selina</span> ; <span style=\"font-variant:small-caps;\">Lange-Hegermann, Markus</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>A systematic, model-based workflow for risk-based decision making in upstream development</i> : DECHEMA e.V.","chicago-de":"Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann und Björn Frahm. <i>A systematic, model-based workflow for risk-based decision making in upstream development</i>. DECHEMA e.V.","ama":"Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>. DECHEMA e.V.","ieee":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, and B. Frahm, <i>A systematic, model-based workflow for risk-based decision making in upstream development</i>. DECHEMA e.V."},"publication_status":"accepted","language":[{"iso":"eng"}],"_id":"11381","date_created":"2024-04-26T06:18:20Z","type":"conference_poster","user_id":"83781","date_updated":"2024-08-02T13:57:27Z"},{"date_created":"2024-04-26T06:22:50Z","type":"conference_poster","date_updated":"2025-01-29T13:42:42Z","user_id":"45666","oa":"1","language":[{"iso":"eng"}],"_id":"11382","title":"View on a mechanistic model of Chlorella vulgaris in shake flasks","publication_status":"accepted","citation":{"short":"V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks, n.d.","chicago-de":"Gassenmeier, Veronika, Fabian Kuhfuß, Sahar Deppe, George Ifrim, Tanja Hernández Rodriguez und Björn Frahm. <i>View on a mechanistic model of Chlorella vulgaris in shake flasks</i>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Gassenmeier, Veronika</span> ; <span style=\"font-variant:small-caps;\">Kuhfuß, Fabian</span> ; <span style=\"font-variant:small-caps;\">Deppe, Sahar</span> ; <span style=\"font-variant:small-caps;\">Ifrim, George</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>View on a mechanistic model of Chlorella vulgaris in shake flasks</i>","ieee":"V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, and B. Frahm, <i>View on a mechanistic model of Chlorella vulgaris in shake flasks</i>.","apa":"Gassenmeier, V., Kuhfuß, F., Deppe, S., Ifrim, G., Hernández Rodriguez, T., &#38; Frahm, B. (n.d.). <i>View on a mechanistic model of Chlorella vulgaris in shake flasks</i>. BioProcessingDays 2023, Recklinghausen, Germany.","chicago":"Gassenmeier, Veronika, Fabian Kuhfuß, Sahar Deppe, George Ifrim, Tanja Hernández Rodriguez, and Björn Frahm. <i>View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks</i>, n.d.","ama":"Gassenmeier V, Kuhfuß F, Deppe S, Ifrim G, Hernández Rodriguez T, Frahm B. <i>View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks</i>.","van":"Gassenmeier V, Kuhfuß F, Deppe S, Ifrim G, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in shake flasks.","havard":"V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in shake flasks, n.d.","mla":"Gassenmeier, Veronika, et al. <i>View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks</i>.","bjps":"<b>Gassenmeier V <i>et al.</i></b> (n.d.) <i>View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks</i>. .","ufg":"<b>Gassenmeier, Veronika u. a.</b>: View on a mechanistic model of Chlorella vulgaris in shake flasks, o. O. u. J. ."},"department":[{"_id":"DEP4000"}],"conference":{"name":"BioProcessingDays 2023","location":"Recklinghausen, Germany","end_date":"20203-03-01","start_date":"2023-02-27"},"author":[{"first_name":"Veronika","id":"74048","last_name":"Gassenmeier","full_name":"Gassenmeier, Veronika"},{"full_name":"Kuhfuß, Fabian","last_name":"Kuhfuß","first_name":"Fabian"},{"first_name":"Sahar","full_name":"Deppe, Sahar","last_name":"Deppe"},{"first_name":"George","full_name":"Ifrim, George","last_name":"Ifrim"},{"last_name":"Hernández Rodriguez","first_name":"Tanja","id":"52466","full_name":"Hernández Rodriguez, Tanja"},{"full_name":"Frahm, Björn","first_name":"Björn","id":"45666","last_name":"Frahm"}],"main_file_link":[{"url":"http://www.apz-rl.de/BioProcessingDays_2023/002_download/BPDs_2023_Tagungsbuch_Titel.pdf","open_access":"1"}],"year":"2023","status":"public"},{"date_created":"2024-04-26T06:40:20Z","type":"conference_speech","date_updated":"2024-05-21T09:06:45Z","user_id":"83781","_id":"11383","language":[{"iso":"eng"}],"title":"Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture","publication_status":"published","citation":{"short":"T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, DECHEMA e.V., 2023.","chicago-de":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, Markus Lange-Hegermann, Florian M. Wurm und Björn Frahm. 2023. <i>Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture</i>. DECHEMA e.V.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Posch, Christoph</span> ; <span style=\"font-variant:small-caps;\">Pörtner, Ralf</span> ; <span style=\"font-variant:small-caps;\">Lange-Hegermann, Markus</span> ; <span style=\"font-variant:small-caps;\">Wurm, Florian M.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture</i> : DECHEMA e.V., 2023","van":"Hernández Rodriguez T, Posch C, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture. DECHEMA e.V.; 2023.","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (2023) <i>Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture</i>. DECHEMA e.V.","havard":"T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture, DECHEMA e.V., 2023.","mla":"Hernández Rodriguez, Tanja, et al. <i>Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture</i>. DECHEMA e.V., 2023.","ufg":"<b>Hernández Rodriguez, Tanja u. a.</b>: Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture, o. O. 2023.","apa":"Hernández Rodriguez, T., Posch, C., Pörtner, R., Lange-Hegermann, M., Wurm, F. M., &#38; Frahm, B. (2023). <i>Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture</i>. 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Berlin, Germany. DECHEMA e.V.","chicago":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, Markus Lange-Hegermann, Florian M. Wurm, and Björn Frahm. <i>Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture</i>. DECHEMA e.V., 2023.","ama":"Hernández Rodriguez T, Posch C, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. <i>Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture</i>. DECHEMA e.V.; 2023.","ieee":"T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F. M. Wurm, and B. Frahm, <i>Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture</i>. DECHEMA e.V., 2023."},"department":[{"_id":"DEP4000"}],"conference":{"end_date":"2023-09-21","start_date":"2023-09-17","location":"Berlin, Germany","name":"14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology"},"author":[{"full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja","id":"52466","last_name":"Hernández Rodriguez"},{"full_name":"Posch, Christoph","first_name":"Christoph","last_name":"Posch"},{"full_name":"Pörtner, Ralf","first_name":"Ralf","last_name":"Pörtner"},{"first_name":"Markus","last_name":"Lange-Hegermann","full_name":"Lange-Hegermann, Markus","id":"71761"},{"last_name":"Wurm","full_name":"Wurm, Florian M.","first_name":"Florian M."},{"first_name":"Björn","id":"45666","full_name":"Frahm, Björn","last_name":"Frahm"}],"year":"2023","publisher":"DECHEMA e.V.","status":"public"},{"date_created":"2024-04-26T06:52:48Z","publication":"Chemie Ingenieur Technik","publication_identifier":{"eissn":["1522-2640"],"issn":["0009-286X"]},"date_updated":"2025-06-26T07:50:29Z","language":[{"iso":"eng"}],"keyword":["Acid-base equilibria","Carboxylic acids","Dissociation constants","pH calculation software","Uncertainty assessment"],"title":"Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations","citation":{"ieee":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, and M. Wichern, “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations,” <i>Chemie Ingenieur Technik</i>, vol. 95, no. 12, pp. 1960–1969, 2023, doi: <a href=\"https://doi.org/10.1002/cite.202300082\">10.1002/cite.202300082</a>.","ama":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. <i>Chemie Ingenieur Technik</i>. 2023;95(12):1960-1969. doi:<a href=\"https://doi.org/10.1002/cite.202300082\">10.1002/cite.202300082</a>","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kosse, Pascal</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Lübken, Manfred</span> ; <span style=\"font-variant:small-caps;\">Wichern, Marc</span>: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. In: <i>Chemie Ingenieur Technik</i> Bd. 95. Weinheim, Wiley (2023), Nr. 12, S. 1960–1969","chicago-de":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken und Marc Wichern. 2023. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. <i>Chemie Ingenieur Technik</i> 95, Nr. 12: 1960–1969. doi:<a href=\"https://doi.org/10.1002/cite.202300082\">10.1002/cite.202300082</a>, .","short":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 95 (2023) 1960–1969.","chicago":"Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken, and Marc Wichern. “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations.” <i>Chemie Ingenieur Technik</i> 95, no. 12 (2023): 1960–69. <a href=\"https://doi.org/10.1002/cite.202300082\">https://doi.org/10.1002/cite.202300082</a>.","apa":"Kosse, P., Hernández Rodriguez, T., Frahm, B., Lübken, M., &#38; Wichern, M. (2023). Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. <i>Chemie Ingenieur Technik</i>, <i>95</i>(12), 1960–1969. <a href=\"https://doi.org/10.1002/cite.202300082\">https://doi.org/10.1002/cite.202300082</a>","bjps":"<b>Kosse P <i>et al.</i></b> (2023) Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations. <i>Chemie Ingenieur Technik</i> <b>95</b>, 1960–1969.","havard":"P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, Chemie Ingenieur Technik. 95 (2023) 1960–1969.","mla":"Kosse, Pascal, et al. “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations.” <i>Chemie Ingenieur Technik</i>, vol. 95, no. 12, 2023, pp. 1960–69, <a href=\"https://doi.org/10.1002/cite.202300082\">https://doi.org/10.1002/cite.202300082</a>.","ufg":"<b>Kosse, Pascal u. a.</b>: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, in: <i>Chemie Ingenieur Technik</i> 95 (2023), H. 12,  S. 1960–1969.","van":"Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik. 2023;95(12):1960–9."},"volume":95,"external_id":{"isi":["001073579300001"]},"author":[{"first_name":"Pascal","full_name":"Kosse, Pascal","last_name":"Kosse"},{"first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja","id":"52466","last_name":"Hernández Rodriguez"},{"first_name":"Björn","id":"45666","last_name":"Frahm","full_name":"Frahm, Björn"},{"first_name":"Manfred","full_name":"Lübken, Manfred","last_name":"Lübken"},{"full_name":"Wichern, Marc","first_name":"Marc","last_name":"Wichern"}],"year":"2023","page":"1960-1969","status":"public","type":"scientific_journal_article","intvolume":"        95","user_id":"83781","doi":"10.1002/cite.202300082","_id":"11385","place":"Weinheim","isi":"1","publication_status":"published","abstract":[{"lang":"eng","text":"Accurate pH calculations are essential for scientists across different disciplines to design optimal reactor solutions, but they can be arduous to calculate for complex acid-base solutions. Visual Water is a powerful software tool that provides accurate pH calculations with automated mathematical uncertainty analysis. Its workflow is presented and validated using acids and bases, showing a deviation of < 0.2 pH units between measured and calculated pH values. This highlights the software's reliability, which can help to simplify the work of non-experts in water chemistry."}],"issue":"12","department":[{"_id":"DEP4000"}],"quality_controlled":"1","publisher":"Wiley"},{"language":[{"iso":"eng"}],"_id":"11487","oa":"1","user_id":"83781","date_updated":"2024-05-21T09:37:15Z","type":"conference_poster","date_created":"2024-05-21T09:37:09Z","status":"public","publisher":"DECHEMA e.V.","author":[{"full_name":"Ramm, Selina","id":"68713","last_name":"Ramm","first_name":"Selina","orcid":"https://orcid.org/0000-0002-0502-8032"},{"id":"52466","first_name":"Tanja","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja"},{"first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn","id":"45666"},{"orcid":"0000-0002-7920-0595","id":"64952","full_name":"Pein-Hackelbusch, Miriam","last_name":"Pein-Hackelbusch","first_name":"Miriam"}],"year":"2023","main_file_link":[{"url":"http://www.apz-rl.de/BioProcessingDays_2023/002_download/BPDs_2023_Tagungsbuch_Titel.pdf","open_access":"1"}],"department":[{"_id":"DEP4000"}],"conference":{"location":"Berlin, Germany","name":"14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology","start_date":"2023-09-17","end_date":"2023-09-21"},"citation":{"ama":"Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. <i>Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression </i>. DECHEMA e.V.","ieee":"S. Ramm, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, <i>Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression </i>. DECHEMA e.V.","short":"S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d.","chicago-de":"Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. <i>Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression </i>. DECHEMA e.V.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Ramm, Selina</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span>: <i>Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression </i> : DECHEMA e.V.","van":"Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression . DECHEMA e.V.;","havard":"S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d.","mla":"Ramm, Selina, et al. <i>Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression </i>. DECHEMA e.V.","bjps":"<b>Ramm S <i>et al.</i></b> (n.d.) <i>Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression </i>. DECHEMA e.V.","ufg":"<b>Ramm, Selina u. a.</b>: Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , o. O. u. J. .","apa":"Ramm, S., Hernández Rodriguez, T., Frahm, B., &#38; Pein-Hackelbusch, M. (n.d.). <i>Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression </i>. 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Berlin, Germany. DECHEMA e.V.","chicago":"Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm, and Miriam Pein-Hackelbusch. <i>Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression </i>. DECHEMA e.V., n.d."},"publication_status":"accepted","title":"Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression "},{"citation":{"chicago-de":"Uhlendorff, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. 2023. <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Uhlendorff, Selina</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span>: <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>, 2023","short":"S. Uhlendorff, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023.","ufg":"<b>Uhlendorff, Selina u. a.</b>: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, o. O. 2023.","bjps":"<b>Uhlendorff S <i>et al.</i></b> (2023) <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. .","havard":"S. Uhlendorff, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023.","mla":"Uhlendorff, Selina, et al. <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. 2023.","van":"Uhlendorff S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. 2023.","chicago":"Uhlendorff, Selina, Tanja Hernández Rodriguez, Björn Frahm, and Miriam Pein-Hackelbusch. <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>, 2023.","apa":"Uhlendorff, S., Hernández Rodriguez, T., Frahm, B., &#38; Pein-Hackelbusch, M. (2023). <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. IEEE International Conference on Industrial Informatics, INDIN ’23, Lemgo, Germany.","ama":"Uhlendorff S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>.; 2023.","ieee":"S. Uhlendorff, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. 2023."},"title":"Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities","status":"public","conference":{"end_date":"2023-07-20","start_date":"2023-07-17","name":"IEEE International Conference on Industrial Informatics, INDIN ’23","location":"Lemgo, Germany"},"department":[{"_id":"DEP4000"}],"author":[{"id":"68713","first_name":"Selina","full_name":"Uhlendorff, Selina","last_name":"Uhlendorff","orcid":"https://orcid.org/0000-0002-0502-8032"},{"first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja","id":"52466","last_name":"Hernández Rodriguez"},{"first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn","id":"45666"},{"full_name":"Pein-Hackelbusch, Miriam","first_name":"Miriam","last_name":"Pein-Hackelbusch","id":"64952","orcid":"0000-0002-7920-0595"}],"year":"2023","date_updated":"2026-04-08T13:09:47Z","user_id":"83778","date_created":"2026-03-27T16:43:01Z","type":"conference_speech","language":[{"iso":"eng"}],"_id":"13650"},{"oa":"1","_id":"10201","language":[{"iso":"eng"}],"date_created":"2023-08-08T14:54:44Z","type":"conference_poster","user_id":"83781","date_updated":"2024-08-02T09:41:01Z","year":"2023","author":[{"id":"52466","first_name":"Tanja","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja"},{"orcid":"https://orcid.org/0000-0002-0502-8032","last_name":"Ramm","first_name":"Selina","id":"68713","full_name":"Ramm, Selina"},{"id":"71761","first_name":"Markus","last_name":"Lange-Hegermann","full_name":"Lange-Hegermann, Markus"},{"id":"45666","last_name":"Frahm","full_name":"Frahm, Björn","first_name":"Björn"}],"main_file_link":[{"url":"http://www.apz-rl.de/BioProcessingDays_2023/002_download/BPDs_2023_Tagungsbuch_Titel.pdf","open_access":"1"}],"department":[{"_id":"DEP4000"}],"conference":{"location":"Recklinghausen, Germany","name":"BioProcessingDays 2023","end_date":"2023-03-01","start_date":"2023-02-27"},"status":"public","title":"A systematic, model-based workflow for risk-based decision making in upstream development","citation":{"ama":"Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>.; 2023.","ieee":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, and B. Frahm, <i>A systematic, model-based workflow for risk-based decision making in upstream development</i>. 2023.","van":"Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development. 2023.","ufg":"<b>Hernández Rodriguez, Tanja u. a.</b>: A systematic, model-based workflow for risk-based decision making in upstream development, o. O. 2023.","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (2023) <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>. .","mla":"Hernández Rodriguez, Tanja, et al. <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>. 2023.","havard":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, 2023.","apa":"Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., &#38; Frahm, B. (2023). <i>A systematic, model-based workflow for risk-based decision making in upstream development</i>. BioProcessingDays 2023, Recklinghausen, Germany.","chicago":"Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann, and Björn Frahm. <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>, 2023.","short":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, 2023.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Ramm, Selina</span> ; <span style=\"font-variant:small-caps;\">Lange-Hegermann, Markus</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>A systematic, model-based workflow for risk-based decision making in upstream development</i>, 2023","chicago-de":"Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann und Björn Frahm. 2023. <i>A systematic, model-based workflow for risk-based decision making in upstream development</i>."},"publication_status":"published"},{"publisher":"IEEE","conference":{"end_date":"2023-07-20","start_date":"2023-07-18","location":"Lemgo","name":"21st International Conference on Industrial Informatics (INDIN)"},"department":[{"_id":"DEP4022"},{"_id":"DEP4028"}],"abstract":[{"lang":"eng","text":"For process monitoring, an adequate data preprocessing is crucial to link accessible inline process data with offline measured target variables. Literature, however, does not provide systematic preprocessing strategies. The effects of five different preprocessing strategies on data from a Dielectric Spectroscopy system applied to the Viable Cell Density (VCD) of a mammalian cell cultivation were thus evaluated. Single-frequency measurements are typically used to model the VCD over the growth phase using linear regression or the Cole-Cole model and served as a reference. As multi-frequency measurement is promising to model the VCD beyond the growth phase using Partial Least Squares Regression (PLSR), we further aimed to determine, whether replacing linear regression by PLSR shows comparable modeling performance. All five preprocessing strategies led to comparable results. Exemplary, when using capacitance values at a frequency of 3347 kHz, linear regression resulted in a R2 of 0.90 and a standard deviation of 0.4 % on average. Both normalization techniques had the same positive effect on the results of PLSR. The order of smoothing and normalization was irrelevant for both regression methods. Comparing the results of linear regression and PLSR, the latter obtained on average 9 % better results. Therefore, we concluded that PLSR is preferable over linear regression and is potentially suitable to model the VCD beyond the growth phase, which is suggested to be investigated based on more data sets."}],"publication_status":"published","place":"[Piscataway, NJ]","doi":"10.1109/INDIN51400.2023.10218012","_id":"10788","user_id":"83781","type":"conference_editor_article","page":"1-6","status":"public","main_file_link":[{"url":"https://ieeexplore.ieee.org/document/10218012","open_access":"1"}],"author":[{"last_name":"Ramm","first_name":"Selina","full_name":"Ramm, Selina","id":"68713","orcid":"https://orcid.org/0000-0002-0502-8032"},{"first_name":"Tanja","id":"52466","full_name":"Hernández Rodriguez, Tanja","last_name":"Hernández Rodriguez"},{"id":"45666","first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn"},{"first_name":"Miriam","id":"64952","full_name":"Pein-Hackelbusch, Miriam","last_name":"Pein-Hackelbusch","orcid":"0000-0002-7920-0595"}],"year":"2023","citation":{"ama":"Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. (Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , eds.). IEEE; 2023:1-6. doi:<a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">10.1109/INDIN51400.2023.10218012</a>","ieee":"S. Ramm, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. [Piscataway, NJ]: IEEE, 2023, pp. 1–6. doi: <a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">10.1109/INDIN51400.2023.10218012</a>.","van":"Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , editors. 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE; 2023.","havard":"S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.","bjps":"<b>Ramm S <i>et al.</i></b> (2023) <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>, Jasperneite J et al. (eds). [Piscataway, NJ]: IEEE.","mla":"Ramm, Selina, et al. “Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities.” <i>2023 IEEE 21st International Conference on Industrial Informatics (INDIN)</i>, edited by Jürgen Jasperneite et al., IEEE, 2023, pp. 1–6, <a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">https://doi.org/10.1109/INDIN51400.2023.10218012</a>.","ufg":"<b>Ramm, Selina u. a.</b>: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, hg. von Jasperneite, Jürgen u. a., [Piscataway, NJ] 2023.","apa":"Ramm, S., Hernández Rodriguez, T., Frahm, B., &#38; Pein-Hackelbusch, M. (2023). Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. In J. Jasperneite, L. Wisniewski, K. Fung Man, &#38; Institute of Electrical and Electronics Engineers  (Eds.), <i>2023 IEEE 21st International Conference on Industrial Informatics (INDIN)</i> (pp. 1–6). IEEE. <a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">https://doi.org/10.1109/INDIN51400.2023.10218012</a>","chicago":"Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm, and Miriam Pein-Hackelbusch. <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. Edited by Jürgen Jasperneite, Lukasz Wisniewski, Kim Fung Man, and Institute of Electrical and Electronics Engineers . <i>2023 IEEE 21st International Conference on Industrial Informatics (INDIN)</i>. [Piscataway, NJ]: IEEE, 2023. <a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">https://doi.org/10.1109/INDIN51400.2023.10218012</a>.","short":"S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Ramm, Selina</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Pein-Hackelbusch, Miriam</span> ; <span style=\"font-variant:small-caps;\">Jasperneite, J.</span> ; <span style=\"font-variant:small-caps;\">Wisniewski, L.</span> ; <span style=\"font-variant:small-caps;\">Fung Man, K.</span> ; <span style=\"font-variant:small-caps;\">Institute of Electrical and Electronics Engineers </span> (Hrsg.): <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. [Piscataway, NJ] : IEEE, 2023","chicago-de":"Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. 2023. <i>Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities</i>. Hg. von Jürgen Jasperneite, Lukasz Wisniewski, Kim Fung Man, und Institute of Electrical and Electronics Engineers . <i>2023 IEEE 21st International Conference on Industrial Informatics (INDIN)</i>. [Piscataway, NJ]: IEEE. doi:<a href=\"https://doi.org/10.1109/INDIN51400.2023.10218012\">10.1109/INDIN51400.2023.10218012</a>, ."},"title":"Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities","language":[{"iso":"eng"}],"keyword":["Spectroscopy","Smoothing methods","Systematics","Phase measurement","Linear regression","Data models","Dielectric measurement"],"oa":"1","date_updated":"2025-04-29T07:38:03Z","editor":[{"full_name":"Jasperneite, Jürgen","last_name":"Jasperneite","id":"1899","first_name":"Jürgen"},{"full_name":"Wisniewski, Lukasz","first_name":"Lukasz","last_name":"Wisniewski","id":"1710"},{"last_name":"Fung Man","first_name":"Kim","full_name":"Fung Man, Kim"}],"corporate_editor":["Institute of Electrical and Electronics Engineers "],"date_created":"2023-11-21T08:17:12Z","publication":"2023 IEEE 21st International Conference on Industrial Informatics (INDIN)","publication_identifier":{"issn":["1935-4576"],"eisbn":["978-1-6654-9313-0"],"isbn":["978-1-6654-9314-7"]}},{"date_updated":"2024-05-21T09:30:15Z","publication_identifier":{"eissn":["2227-9717"]},"publication":"Processes","date_created":"2024-04-25T13:35:04Z","keyword":["Gaussian processes","Bayes optimization","Pareto optimization","multi-objective","cell culture","seed train"],"language":[{"iso":"eng"}],"citation":{"chicago":"Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann, and Björn Frahm. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” <i>Processes</i> 10, no. 5 (2022). <a href=\"https://doi.org/10.3390/pr10050883\">https://doi.org/10.3390/pr10050883</a>.","apa":"Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., &#38; Frahm, B. (2022). Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. <i>Processes</i>, <i>10</i>(5), Article 883. <a href=\"https://doi.org/10.3390/pr10050883\">https://doi.org/10.3390/pr10050883</a>","ieee":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, and B. Frahm, “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design,” <i>Processes</i>, vol. 10, no. 5, Art. no. 883, 2022, doi: <a href=\"https://doi.org/10.3390/pr10050883\">10.3390/pr10050883</a>.","ufg":"<b>Hernández Rodriguez, Tanja u. a.</b>: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, in: <i>Processes</i> 10 (2022), H. 5.","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (2022) Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. <i>Processes</i> <b>10</b>.","mla":"Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” <i>Processes</i>, vol. 10, no. 5, 883, 2022, <a href=\"https://doi.org/10.3390/pr10050883\">https://doi.org/10.3390/pr10050883</a>.","havard":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, Processes. 10 (2022).","van":"Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes. 2022;10(5).","ama":"Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. <i>Processes</i>. 2022;10(5). doi:<a href=\"https://doi.org/10.3390/pr10050883\">10.3390/pr10050883</a>","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Sekulic, Anton</span> ; <span style=\"font-variant:small-caps;\">Lange-Hegermann, Markus</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In: <i>Processes</i> Bd. 10. Basel, MDPI AG (2022), Nr. 5","chicago-de":"Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann und Björn Frahm. 2022. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. <i>Processes</i> 10, Nr. 5. doi:<a href=\"https://doi.org/10.3390/pr10050883\">10.3390/pr10050883</a>, .","short":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Processes 10 (2022)."},"volume":10,"title":"Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design","status":"public","author":[{"last_name":"Hernández Rodriguez","id":"52466","full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja"},{"first_name":"Anton","last_name":"Sekulic","full_name":"Sekulic, Anton"},{"full_name":"Lange-Hegermann, Markus","first_name":"Markus","last_name":"Lange-Hegermann","id":"71761"},{"full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn","id":"45666"}],"year":"2022","intvolume":"        10","user_id":"83781","type":"scientific_journal_article","_id":"11377","article_number":"883","doi":"10.3390/pr10050883","place":"Basel","publication_status":"published","publisher":"MDPI AG","issue":"5","abstract":[{"text":"<jats:p>consuming and often performed rather empirically. Efficient optimization of multiple objectives such as process time, viable cell density, number of operating steps &amp; cultivation scales, required medium, amount of product as well as product quality depicts a promising approach. This contribution presents a workflow which couples uncertainty-based upstream simulation and Bayes optimization using Gaussian processes. Its application is demonstrated in a simulation case study for a relevant industrial task in process development, the design of a robust cell culture expansion process (seed train), meaning that despite uncertainties and variabilities concerning cell growth, low variations of viable cell density during the seed train are obtained. Compared to a non-optimized reference seed train, the optimized process showed much lower deviation rates regarding viable cell densities (&lt;10% instead of 41.7%) using five or four shake flask scales and seed train duration could be reduced by 56 h from 576 h to 520 h. Overall, it is shown that applying Bayes optimization allows for optimization of a multi-objective optimization function with several optimizable input variables and under a considerable amount of constraints with a low computational effort. This approach provides the potential to be used in the form of a decision tool, e.g., for the choice of an optimal and robust seed train design or for further optimization tasks within process development.","lang":"eng"}],"department":[{"_id":"DEP4000"}]},{"_id":"7932","language":[{"iso":"eng"}],"user_id":"83781","date_updated":"2024-08-02T13:57:53Z","type":"conference_poster","date_created":"2022-05-04T19:35:20Z","status":"public","author":[{"id":"52466","first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja","last_name":"Hernández Rodriguez"},{"orcid":"https://orcid.org/0000-0002-0502-8032","full_name":"Ramm, Selina","last_name":"Ramm","first_name":"Selina","id":"68713"},{"full_name":"Lange-Hegermann, Markus","id":"71761","last_name":"Lange-Hegermann","first_name":"Markus"},{"full_name":"Frahm, Björn","last_name":"Frahm","first_name":"Björn","id":"45666"}],"year":"2022","department":[{"_id":"DEP4021"}],"conference":{"location":"Barcelona, Spain","name":"5th annual Bioprocessing Summit Europe","start_date":"2022-03-22","end_date":"2022-03-24"},"citation":{"van":"Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development.","ama":"Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>.","ufg":"<b>Hernández Rodriguez, Tanja u. a.</b>: A systematic, model-based workflow for risk-based decision making in upstream development, o. O. u. J. .","mla":"Hernández Rodriguez, Tanja, et al. <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>.","havard":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, n.d.","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (n.d.) <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>. .","apa":"Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., &#38; Frahm, B. (n.d.). <i>A systematic, model-based workflow for risk-based decision making in upstream development</i>. 5th annual Bioprocessing Summit Europe, Barcelona, Spain.","ieee":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, and B. Frahm, <i>A systematic, model-based workflow for risk-based decision making in upstream development</i>.","chicago":"Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann, and Björn Frahm. <i>A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development</i>, n.d.","short":"T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, n.d.","chicago-de":"Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann und Björn Frahm. <i>A systematic, model-based workflow for risk-based decision making in upstream development</i>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Ramm, Selina</span> ; <span style=\"font-variant:small-caps;\">Lange-Hegermann, Markus</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>A systematic, model-based workflow for risk-based decision making in upstream development</i>"},"publication_status":"accepted","title":"A systematic, model-based workflow for risk-based decision making in upstream development"},{"language":[{"iso":"eng"}],"_id":"7976","doi":"10.1016/j.crbiot.2022.01.005","publication_identifier":{"eissn":["2590-2628 "]},"publication":"Current Research in Biotechnology","date_created":"2022-05-05T11:14:10Z","type":"scientific_journal_article","user_id":"83781","date_updated":"2024-08-05T07:10:50Z","intvolume":"         4","author":[{"full_name":"Gassenmeier, Veronika","first_name":"Veronika","id":"74048","last_name":"Gassenmeier"},{"last_name":"Deppe","full_name":"Deppe, Sahar","id":"52121","first_name":"Sahar"},{"first_name":"Tanja","id":"52466","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja"},{"first_name":"Fabian","last_name":"Kuhfuß","full_name":"Kuhfuß, Fabian"},{"full_name":"Moser, André","first_name":"André","last_name":"Moser"},{"last_name":"Hass","full_name":"Hass, Volker C.","first_name":"Volker C."},{"last_name":"Kuchemüller","first_name":"Kim B.","full_name":"Kuchemüller, Kim B."},{"full_name":"Pörtner, Ralf","last_name":"Pörtner","first_name":"Ralf"},{"last_name":"Möller","first_name":"Johannes","full_name":"Möller, Johannes"},{"first_name":"George Adrian","last_name":"Ifrim","full_name":"Ifrim, George Adrian","id":"73814"},{"first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm","id":"45666"}],"year":"2022","department":[{"_id":"DEP4021"}],"status":"public","page":"102-119","publisher":"Elsevier","quality_controlled":"1","title":"Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology","citation":{"short":"V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Current Research in Biotechnology 4 (2022) 102–119.","din1505-2-1":"<span style=\"font-variant:small-caps;\"><span style=\"font-variant:small-caps;\">Gassenmeier, Veronika</span> ; <span style=\"font-variant:small-caps;\">Deppe, Sahar</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Kuhfuß, Fabian</span> ; <span style=\"font-variant:small-caps;\">Moser, André</span> ; <span style=\"font-variant:small-caps;\">Hass, Volker C.</span> ; <span style=\"font-variant:small-caps;\">Kuchemüller, Kim B.</span> ; <span style=\"font-variant:small-caps;\">Pörtner, Ralf</span> ; u. a.</span>: Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. In: <i>Current Research in Biotechnology</i> Bd. 4, Elsevier (2022), S. 102–119","chicago-de":"Gassenmeier, Veronika, Sahar Deppe, Tanja Hernández Rodriguez, Fabian Kuhfuß, André Moser, Volker C. Hass, Kim B. Kuchemüller, u. a. 2022. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. <i>Current Research in Biotechnology</i> 4: 102–119. doi:<a href=\"https://doi.org/10.1016/j.crbiot.2022.01.005\">10.1016/j.crbiot.2022.01.005</a>, .","van":"Gassenmeier V, Deppe S, Hernández Rodriguez T, Kuhfuß F, Moser A, Hass VC, et al. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology. 2022;4:102–19.","ama":"Gassenmeier V, Deppe S, Hernández Rodriguez T, et al. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. <i>Current Research in Biotechnology</i>. 2022;4:102-119. doi:<a href=\"https://doi.org/10.1016/j.crbiot.2022.01.005\">10.1016/j.crbiot.2022.01.005</a>","ufg":"<b>Gassenmeier, Veronika u. a.</b>: Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology, in: <i>Current Research in Biotechnology</i> 4 (2022),  S. 102–119.","mla":"Gassenmeier, Veronika, et al. “Model-Assisted DoE Applied to Microalgae Processes, Current Research in Biotechnology.” <i>Current Research in Biotechnology</i>, vol. 4, 2022, pp. 102–19, <a href=\"https://doi.org/10.1016/j.crbiot.2022.01.005\">https://doi.org/10.1016/j.crbiot.2022.01.005</a>.","havard":"V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology, Current Research in Biotechnology. 4 (2022) 102–119.","bjps":"<b>Gassenmeier V <i>et al.</i></b> (2022) Model-Assisted DoE Applied to Microalgae Processes, Current Research in Biotechnology. <i>Current Research in Biotechnology</i> <b>4</b>, 102–119.","apa":"Gassenmeier, V., Deppe, S., Hernández Rodriguez, T., Kuhfuß, F., Moser, A., Hass, V. C., Kuchemüller, K. B., Pörtner, R., Möller, J., Ifrim, G. A., &#38; Frahm, B. (2022). Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. <i>Current Research in Biotechnology</i>, <i>4</i>, 102–119. <a href=\"https://doi.org/10.1016/j.crbiot.2022.01.005\">https://doi.org/10.1016/j.crbiot.2022.01.005</a>","ieee":"V. Gassenmeier <i>et al.</i>, “Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology,” <i>Current Research in Biotechnology</i>, vol. 4, pp. 102–119, 2022, doi: <a href=\"https://doi.org/10.1016/j.crbiot.2022.01.005\">10.1016/j.crbiot.2022.01.005</a>.","chicago":"Gassenmeier, Veronika, Sahar Deppe, Tanja Hernández Rodriguez, Fabian Kuhfuß, André Moser, Volker C. Hass, Kim B. Kuchemüller, et al. “Model-Assisted DoE Applied to Microalgae Processes, Current Research in Biotechnology.” <i>Current Research in Biotechnology</i> 4 (2022): 102–19. <a href=\"https://doi.org/10.1016/j.crbiot.2022.01.005\">https://doi.org/10.1016/j.crbiot.2022.01.005</a>."},"volume":4,"publication_status":"published"},{"year":"2022","author":[{"first_name":"Fabian","full_name":"Kuhfuß, Fabian","last_name":"Kuhfuß"},{"first_name":"Veronika","last_name":"Gassenmeier","full_name":"Gassenmeier, Veronika","id":"74048"},{"id":"52121","full_name":"Deppe, Sahar","last_name":"Deppe","first_name":"Sahar"},{"id":"73814","last_name":"Ifrim","first_name":"George Adrian","full_name":"Ifrim, George Adrian"},{"id":"52466","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja"},{"id":"45666","first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn"}],"page":"15-30","status":"public","title":"View on a mechanistic model of Chlorella vulgaris in incubated shake flasks","volume":45,"citation":{"ama":"Kuhfuß F, Gassenmeier V, Deppe S, Ifrim GA, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. <i>Bioprocess and Biosystems Engineering</i>. 2022;45:15-30. doi:<a href=\"https://doi.org/10.1007/s00449-021-02627-2\">10.1007/s00449-021-02627-2</a>","ieee":"F. Kuhfuß, V. Gassenmeier, S. Deppe, G. A. Ifrim, T. Hernández Rodriguez, and B. Frahm, “View on a mechanistic model of Chlorella vulgaris in incubated shake flasks,” <i>Bioprocess and Biosystems Engineering</i>, vol. 45, pp. 15–30, 2022, doi: <a href=\"https://doi.org/10.1007/s00449-021-02627-2\">10.1007/s00449-021-02627-2</a>.","ufg":"<b>Kuhfuß, Fabian u. a.</b>: View on a mechanistic model of Chlorella vulgaris in incubated shake flasks, in: <i>Bioprocess and Biosystems Engineering</i> 45 (2022),  S. 15–30.","bjps":"<b>Kuhfuß F <i>et al.</i></b> (2022) View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks. <i>Bioprocess and Biosystems Engineering</i> <b>45</b>, 15–30.","havard":"F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in incubated shake flasks, Bioprocess and Biosystems Engineering. 45 (2022) 15–30.","mla":"Kuhfuß, Fabian, et al. “View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks.” <i>Bioprocess and Biosystems Engineering</i>, vol. 45, 2022, pp. 15–30, <a href=\"https://doi.org/10.1007/s00449-021-02627-2\">https://doi.org/10.1007/s00449-021-02627-2</a>.","van":"Kuhfuß F, Gassenmeier V, Deppe S, Ifrim GA, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering. 2022;45:15–30.","chicago":"Kuhfuß, Fabian, Veronika Gassenmeier, Sahar Deppe, George Adrian Ifrim, Tanja Hernández Rodriguez, and Björn Frahm. “View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks.” <i>Bioprocess and Biosystems Engineering</i> 45 (2022): 15–30. <a href=\"https://doi.org/10.1007/s00449-021-02627-2\">https://doi.org/10.1007/s00449-021-02627-2</a>.","apa":"Kuhfuß, F., Gassenmeier, V., Deppe, S., Ifrim, G. A., Hernández Rodriguez, T., &#38; Frahm, B. (2022). View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. <i>Bioprocess and Biosystems Engineering</i>, <i>45</i>, 15–30. <a href=\"https://doi.org/10.1007/s00449-021-02627-2\">https://doi.org/10.1007/s00449-021-02627-2</a>","din1505-2-1":"<span style=\"font-variant:small-caps;\">Kuhfuß, Fabian</span> ; <span style=\"font-variant:small-caps;\">Gassenmeier, Veronika</span> ; <span style=\"font-variant:small-caps;\">Deppe, Sahar</span> ; <span style=\"font-variant:small-caps;\">Ifrim, George Adrian</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. In: <i>Bioprocess and Biosystems Engineering</i> Bd. 45. Berlin, Springer (2022), S. 15–30","chicago-de":"Kuhfuß, Fabian, Veronika Gassenmeier, Sahar Deppe, George Adrian Ifrim, Tanja Hernández Rodriguez und Björn Frahm. 2022. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. <i>Bioprocess and Biosystems Engineering</i> 45: 15–30. doi:<a href=\"https://doi.org/10.1007/s00449-021-02627-2\">10.1007/s00449-021-02627-2</a>, .","short":"F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, Bioprocess and Biosystems Engineering 45 (2022) 15–30."},"language":[{"iso":"eng"}],"date_created":"2022-05-05T11:28:56Z","publication_identifier":{"eissn":["1615-7605"],"issn":["1615-7591 "]},"publication":"Bioprocess and Biosystems Engineering","date_updated":"2024-08-05T07:07:37Z","department":[{"_id":"DEP4021"}],"abstract":[{"lang":"eng","text":"Kinetic growth models are a useful tool for a better understanding of microalgal cultivation and for optimizing cultivation conditions. The evaluation of such models requires experimental data that is laborious to generate in bioreactor settings. The experimental shake flask setting used in this study allows to run 12 experiments at the same time, with 6 individual light intensities and light durations. This way, 54 biomass data sets were generated for the cultivation of the microalgae Chlorella vulgaris. To identify the model parameters, a stepwise parameter estimation procedure was applied. First, light-associated model parameters were estimated using additional measurements of local light intensities at differ heights within medium at different biomass concentrations. Next, substrate related model parameters were estimated, using experiments for which biomass and nitrate data were provided. Afterwards, growth-related model parameters were estimated by application of an extensive cross validation procedure."}],"quality_controlled":"1","publisher":"Springer","publication_status":"published","place":"Berlin","doi":"10.1007/s00449-021-02627-2","_id":"7977","type":"scientific_journal_article","user_id":"83781","intvolume":"        45"},{"doi":"https://doi.org/10.3390/pr10050883","_id":"10193","language":[{"iso":"eng"}],"place":"Basel","keyword":["Gaussian processes","Bayes optimization","Pareto optimization","multi-objective","cell culture","seed train"],"type":"book_chapter","date_created":"2023-08-08T12:58:36Z","publication_identifier":{"eisbn":["978-3-0365-5209-5"],"isbn":["978-3-0365-5210-1"],"eissn":["2227-9717"]},"publication":"Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing","editor":[{"last_name":"Pörtner","first_name":"Ralf","full_name":"Pörtner, Ralf"},{"first_name":"Johannes","full_name":"Möller, Johannes","last_name":"Möller"}],"date_updated":"2023-08-16T09:24:16Z","user_id":"83781","abstract":[{"lang":"eng","text":"Development and optimization of biopharmaceutical production processes with cell cultures is cost- and time-consuming and often performed rather empirically. Efficient optimization of multiple objectives such as process time, viable cell density, number of operating steps & cultivation scales, required medium, amount of product as well as product quality depicts a promising approach. This contribution presents a workflow which couples uncertainty-based upstream simulation and Bayes optimization using Gaussian processes. Its application is demonstrated in a simulation case study for a relevant industrial task in process development, the design of a robust cell culture expansion process (seed train), meaning that despite uncertainties and variabilities concerning cell growth, low variations of viable cell density during the seed train are obtained. Compared to a non-optimized reference seed train, the optimized process showed much lower deviation rates regarding viable cell densities (<10% instead of 41.7%) using five or four shake flask scales and seed train duration could be reduced by 56 h from 576 h to 520 h. Overall, it is shown that applying Bayes optimization allows for optimization of a multi-objective optimization function with several optimizable input variables and under a considerable amount of constraints with a low computational effort. This approach provides the potential to be used in the form of a decision tool, e.g., for the choice of an optimal and robust seed train design or for further optimization tasks within process development."}],"department":[{"_id":"DEP4000"}],"author":[{"first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja","id":"52466","last_name":"Hernández Rodriguez"},{"last_name":"Sekulic","full_name":"Sekulic, Anton","first_name":"Anton"},{"full_name":"Lange-Hegermann, Markus","last_name":"Lange-Hegermann","first_name":"Markus","id":"71761"},{"first_name":"Björn","last_name":"Frahm","id":"45666","full_name":"Frahm, Björn"}],"year":"2022","quality_controlled":"1","publisher":"MDPI","page":"21-48","status":"public","title":"Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design","series_title":"Processes : open access journal","publication_status":"published","volume":"special issue","citation":{"short":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022, pp. 21–48.","chicago-de":"Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann und Björn Frahm. 2022. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, hg. von Ralf Pörtner und Johannes Möller, special issue:21–48. Processes : open access journal. Basel: MDPI. doi:<a href=\"https://doi.org/10.3390/pr10050883\">https://doi.org/10.3390/pr10050883</a>, .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Sekulic, Anton</span> ; <span style=\"font-variant:small-caps;\">Lange-Hegermann, Markus</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: <span style=\"font-variant:small-caps;\">Pörtner, R.</span> ; <span style=\"font-variant:small-caps;\">Möller, J.</span> (Hrsg.): <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, <i>Processes : open access journal</i>. Bd. special issue. Basel : MDPI, 2022, S. 21–48","apa":"Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., &#38; Frahm, B. (2022). Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In R. Pörtner &#38; J. Möller (Eds.), <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue</i> (pp. 21–48). MDPI. <a href=\"https://doi.org/10.3390/pr10050883\">https://doi.org/10.3390/pr10050883</a>","ieee":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, and B. Frahm, “Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design,” in <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, vol. special issue, R. Pörtner and J. Möller, Eds. Basel: MDPI, 2022, pp. 21–48. doi: <a href=\"https://doi.org/10.3390/pr10050883\">https://doi.org/10.3390/pr10050883</a>.","chicago":"Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann, and Björn Frahm. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” In <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, edited by Ralf Pörtner and Johannes Möller, special issue:21–48. Processes : Open Access Journal. Basel: MDPI, 2022. <a href=\"https://doi.org/10.3390/pr10050883\">https://doi.org/10.3390/pr10050883</a>.","van":"Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner R, Möller J, editors. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2022. p. 21–48. (Processes : open access journal; vol. special issue).","ama":"Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner R, Möller J, eds. <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>. Vol special issue. Processes : open access journal. MDPI; 2022:21-48. doi:<a href=\"https://doi.org/10.3390/pr10050883\">https://doi.org/10.3390/pr10050883</a>","ufg":"<b>Hernández Rodriguez, Tanja u. a.</b>: Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design, in: <i>Pörtner, Ralf/Möller, Johannes (Hgg.)</i>: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Band <i>special issue</i>, Basel 2022 (Processes : open access journal),  S. 21–48.","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (2022) Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In Pörtner R and Möller J (eds), <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, vol. special issue. Basel: MDPI, pp. 21–48.","havard":"T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022: pp. 21–48.","mla":"Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, edited by Ralf Pörtner and Johannes Möller, vol. special issue, MDPI, 2022, pp. 21–48, <a href=\"https://doi.org/10.3390/pr10050883\">https://doi.org/10.3390/pr10050883</a>."}},{"_id":"10197","language":[{"iso":"eng"}],"publication":"ACHEMA 2022","date_created":"2023-08-08T13:26:41Z","type":"conference_speech","user_id":"83781","date_updated":"2023-08-14T09:40:43Z","author":[{"first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja","last_name":"Hernández Rodriguez","id":"52466"},{"first_name":"Christoph","full_name":"Posch, Christoph","last_name":"Posch"},{"full_name":"Pörtner, Ralf","last_name":"Pörtner","first_name":"Ralf"},{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"}],"year":"2022","conference":{"name":"ACHEMA 2022","location":"Frankfurt am Main, Germany","end_date":"2022-08-26","start_date":"2022-08-22"},"department":[{"_id":"DEP4000"}],"status":"public","title":"Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture","citation":{"mla":"Hernández Rodriguez, Tanja, et al. “Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture.” <i>ACHEMA 2022</i>, 2022.","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (2022) <i>Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture</i>. .","havard":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture, 2022.","ufg":"<b>Hernández Rodriguez, Tanja u. a.</b>: Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture, o. O. 2022.","van":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture. ACHEMA 2022. 2022.","chicago":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, and Björn Frahm. <i>Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture</i>. <i>ACHEMA 2022</i>, 2022.","apa":"Hernández Rodriguez, T., Posch, C., Pörtner, R., &#38; Frahm, B. (2022). Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture. In <i>ACHEMA 2022</i>. ACHEMA 2022, Frankfurt am Main, Germany.","chicago-de":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner und Björn Frahm. 2022. <i>Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture</i>. <i>ACHEMA 2022</i>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Posch, Christoph</span> ; <span style=\"font-variant:small-caps;\">Pörtner, Ralf</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture</i>, 2022","short":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, 2022.","ama":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. <i>Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture</i>.; 2022.","ieee":"T. Hernández Rodriguez, C. Posch, R. Pörtner, and B. Frahm, <i>Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture</i>. 2022."},"publication_status":"published"},{"user_id":"83781","date_updated":"2024-08-02T14:14:55Z","date_created":"2023-08-08T13:50:25Z","type":"conference_poster","language":[{"iso":"eng"}],"_id":"10198","citation":{"short":"T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion, n.d.","chicago-de":"Hernández Rodriguez, Tanja, Ralf Pörtner, Markus Lange-Hegermann, Florian M. Wurm und Björn Frahm. <i>A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion</i>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Pörtner, Ralf</span> ; <span style=\"font-variant:small-caps;\">Lange-Hegermann, Markus</span> ; <span style=\"font-variant:small-caps;\">Wurm, Florian M.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion</i>","apa":"Hernández Rodriguez, T., Pörtner, R., Lange-Hegermann, M., Wurm, F. M., &#38; Frahm, B. (n.d.). <i>A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion</i>. 27th Meeting of the European Society for Animal Cell Technology (ESACT): Advanced Cell Technologies: Making Protein, Cell, and Gene Therapies a Reality, Lisbon, Portugal .","ieee":"T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F. M. Wurm, and B. Frahm, <i>A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion</i>.","chicago":"Hernández Rodriguez, Tanja, Ralf Pörtner, Markus Lange-Hegermann, Florian M. Wurm, and Björn Frahm. <i>A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion</i>, n.d.","van":"Hernández Rodriguez T, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion.","ama":"Hernández Rodriguez T, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. <i>A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion</i>.","ufg":"<b>Hernández Rodriguez, Tanja u. a.</b>: A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion, o. O. u. J. .","mla":"Hernández Rodriguez, Tanja, et al. <i>A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion</i>.","havard":"T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion, n.d.","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (n.d.) <i>A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion</i>. ."},"publication_status":"accepted","title":"A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion","status":"public","quality_controlled":"1","author":[{"first_name":"Tanja","id":"52466","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja"},{"last_name":"Pörtner","full_name":"Pörtner, Ralf","first_name":"Ralf"},{"last_name":"Lange-Hegermann","full_name":"Lange-Hegermann, Markus","id":"71761","first_name":"Markus"},{"first_name":"Florian M.","full_name":"Wurm, Florian M.","last_name":"Wurm"},{"first_name":"Björn","id":"45666","last_name":"Frahm","full_name":"Frahm, Björn"}],"year":"2022","department":[{"_id":"DEP4000"}],"conference":{"end_date":"2022-06-29","start_date":"2022-06-26","location":"Lisbon, Portugal ","name":"27th Meeting of the European Society for Animal Cell Technology (ESACT): Advanced Cell Technologies: Making Protein, Cell, and Gene Therapies a Reality"}},{"publisher":"MDPI AG","department":[{"_id":"DEP4000"}],"issue":"6","abstract":[{"lang":"eng","text":"<jats:p>concentration is an important objective. The phenotype of the cells in a reactor plays an important role. Are clonal cell populations showing high cell-specific growth rates more favorable than cell lines with higher cell-specific productivities or vice versa? Five clonal Chinese hamster ovary cell populations were analyzed based on the data of a 3-month-stability study. We adapted a mechanistic cell culture model to the experimental data of one such clonally derived cell population. Uncertainties and prior knowledge concerning model parameters were considered using Bayesian parameter estimations. This model was used then to define an inoculum train protocol. Based on this, we subsequently simulated the impacts of differences in growth rates (±10%) and production rates (±10% and ±50%) on the overall cultivation time, including making the inoculum train cultures; the final production phase, the volumetric titer in that bioreactor and the ratio of both, defined as overall process productivity. We showed thus unequivocally that growth rates have a higher impact (up to three times) on overall process productivity and for product output per year, whereas cells with higher productivity can potentially generate higher product concentrations in the production vessel."}],"publication_status":"published","place":"Basel","article_number":"964","doi":"10.3390/pr9060964","_id":"11376","user_id":"83781","intvolume":"         9","type":"scientific_journal_article","status":"public","year":"2021","author":[{"first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja","last_name":"Hernández Rodriguez","id":"52466"},{"full_name":"Morerod, Sophie","first_name":"Sophie","last_name":"Morerod"},{"first_name":"Ralf","last_name":"Pörtner","full_name":"Pörtner, Ralf"},{"first_name":"Florian M.","last_name":"Wurm","full_name":"Wurm, Florian M."},{"full_name":"Frahm, Björn","last_name":"Frahm","id":"45666","first_name":"Björn"}],"citation":{"din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Morerod, Sophie</span> ; <span style=\"font-variant:small-caps;\">Pörtner, Ralf</span> ; <span style=\"font-variant:small-caps;\">Wurm, Florian M.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. In: <i>Processes</i> Bd. 9. Basel, MDPI AG (2021), Nr. 6","chicago-de":"Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm und Björn Frahm. 2021. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. <i>Processes</i> 9, Nr. 6. doi:<a href=\"https://doi.org/10.3390/pr9060964\">10.3390/pr9060964</a>, .","short":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Processes 9 (2021).","ufg":"<b>Hernández Rodriguez, Tanja u. a.</b>: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study, in: <i>Processes</i> 9 (2021), H. 6.","havard":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study, Processes. 9 (2021).","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (2021) Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. <i>Processes</i> <b>9</b>.","mla":"Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study.” <i>Processes</i>, vol. 9, no. 6, 964, 2021, <a href=\"https://doi.org/10.3390/pr9060964\">https://doi.org/10.3390/pr9060964</a>.","van":"Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes. 2021;9(6).","ama":"Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. <i>Processes</i>. 2021;9(6). doi:<a href=\"https://doi.org/10.3390/pr9060964\">10.3390/pr9060964</a>","chicago":"Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm, and Björn Frahm. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study.” <i>Processes</i> 9, no. 6 (2021). <a href=\"https://doi.org/10.3390/pr9060964\">https://doi.org/10.3390/pr9060964</a>.","apa":"Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., &#38; Frahm, B. (2021). Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. <i>Processes</i>, <i>9</i>(6), Article 964. <a href=\"https://doi.org/10.3390/pr9060964\">https://doi.org/10.3390/pr9060964</a>","ieee":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F. M. Wurm, and B. Frahm, “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study,” <i>Processes</i>, vol. 9, no. 6, Art. no. 964, 2021, doi: <a href=\"https://doi.org/10.3390/pr9060964\">10.3390/pr9060964</a>."},"volume":9,"title":"Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study","language":[{"iso":"eng"}],"keyword":["clonal cell population","phenotypic diversity","inoculum train","uncertainty-based","cell culture model","biopharmaceutical manufacturing"],"date_updated":"2024-05-21T09:29:02Z","date_created":"2024-04-25T13:34:26Z","publication":"Processes","publication_identifier":{"eissn":["2227-9717"]}},{"language":[{"iso":"eng"}],"_id":"7927","user_id":"83781","date_updated":"2023-08-21T08:11:25Z","date_created":"2022-05-04T19:17:03Z","type":"conference_speech","status":"public","year":"2021","author":[{"first_name":"Tanja","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja","id":"52466"},{"id":"45666","first_name":"Björn","full_name":"Frahm, Björn","last_name":"Frahm"}],"department":[{"_id":"DEP4021"}],"conference":{"start_date":"2021-02-15","end_date":"2021-02-19","location":"SeAMK, Seinäjoki, Finnland","name":"International Week 'Digitalization and Sustainability in Higher Education'"},"citation":{"short":"T. Hernández Rodriguez, B. Frahm, Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction, 2021.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction</i>, 2021","chicago-de":"Hernández Rodriguez, Tanja und Björn Frahm. 2021. <i>Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction</i>.","van":"Hernández Rodriguez T, Frahm B. Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. 2021.","bjps":"<b>Hernández Rodriguez T and Frahm B</b> (2021) <i>Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction</i>. .","havard":"T. Hernández Rodriguez, B. Frahm, Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction, 2021.","mla":"Hernández Rodriguez, Tanja, and Björn Frahm. <i>Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction</i>. 2021.","ufg":"<b>Hernández Rodriguez, Tanja/Frahm, Björn</b>: Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction, o. O. 2021.","apa":"Hernández Rodriguez, T., &#38; Frahm, B. (2021). <i>Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction</i>. International Week “Digitalization and Sustainability in Higher Education,” SeAMK, Seinäjoki, Finnland.","chicago":"Hernández Rodriguez, Tanja, and Björn Frahm. <i>Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction</i>, 2021.","ama":"Hernández Rodriguez T, Frahm B. <i>Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction</i>.; 2021.","ieee":"T. Hernández Rodriguez and B. Frahm, <i>Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction</i>. 2021."},"publication_status":"published","title":"Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction"},{"_id":"7931","language":[{"iso":"eng"}],"type":"conference_poster","date_created":"2022-05-04T19:32:05Z","date_updated":"2023-03-15T13:50:12Z","user_id":"45673","department":[{"_id":"DEP4021"}],"conference":{"location":"as a web conference, Prague, Czech Republic","name":"24th International Congress of Chemical and Process Engineering, CHISA 2021","end_date":"2021-03-18","start_date":"2021-03-15"},"author":[{"last_name":"Moser","first_name":"André","full_name":"Moser, André"},{"last_name":"Möller","full_name":"Möller, Johannes","first_name":"Johannes"},{"first_name":"Kim B.","full_name":"Kuchemüller, Kim B.","last_name":"Kuchemüller"},{"last_name":"Deppe","full_name":"Deppe, Sahar","first_name":"Sahar"},{"first_name":"Tanja","last_name":"Hernández Rodriguez","id":"52466","full_name":"Hernández Rodriguez, Tanja"},{"first_name":"Veronika","full_name":"Gassenmeier, Veronika","last_name":"Gassenmeier","id":"74048"},{"first_name":"George Adrian","last_name":"Ifrim","id":"73814","full_name":"Ifrim, George Adrian"},{"id":"45666","last_name":"Frahm","first_name":"Björn","full_name":"Frahm, Björn"},{"full_name":"Pörtner, Ralf","first_name":"Ralf","last_name":"Pörtner"},{"first_name":"Volker C.","last_name":"Hass","full_name":"Hass, Volker C."}],"year":2021,"status":"public","title":"Model-assisted Design of Experiments - Concept, Software and Applications","citation":{"havard":"A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-assisted Design of Experiments - Concept, Software and Applications, 2021.","mla":"Moser, André, et al. <i>Model-Assisted Design of Experiments - Concept, Software and Applications</i>. 2021.","bjps":"<b>Moser A <i>et al.</i></b> (2021) <i>Model-Assisted Design of Experiments - Concept, Software and Applications</i>. .","ufg":"<b>Moser, André et. al. (2021)</b>: Model-assisted Design of Experiments - Concept, Software and Applications.","ama":"Moser A, Möller J, Kuchemüller KB, et al. <i>Model-Assisted Design of Experiments - Concept, Software and Applications</i>.; 2021.","van":"Moser A, Möller J, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Gassenmeier V, et al. Model-assisted Design of Experiments - Concept, Software and Applications. 2021.","chicago":"Moser, André, Johannes Möller, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Veronika Gassenmeier, George Adrian Ifrim, Björn Frahm, Ralf Pörtner, and Volker C. Hass. <i>Model-Assisted Design of Experiments - Concept, Software and Applications</i>, 2021.","ieee":"A. Moser <i>et al.</i>, <i>Model-assisted Design of Experiments - Concept, Software and Applications</i>. 2021.","apa":"Moser, A., Möller, J., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., … Hass, V. C. (2021). <i>Model-assisted Design of Experiments - Concept, Software and Applications</i>. Presented at the 24th International Congress of Chemical and Process Engineering, CHISA 2021, as a web conference, Prague, Czech Republic.","din1505-2-1":"<span style=\"font-variant:small-caps;\"><span style=\"font-variant:small-caps;\">Moser, André</span> ; <span style=\"font-variant:small-caps;\">Möller, Johannes</span> ; <span style=\"font-variant:small-caps;\">Kuchemüller, Kim B.</span> ; <span style=\"font-variant:small-caps;\">Deppe, Sahar</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Gassenmeier, Veronika</span> ; <span style=\"font-variant:small-caps;\">Ifrim, George Adrian</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; u. a.</span>: <i>Model-assisted Design of Experiments - Concept, Software and Applications</i>, 2021","chicago-de":"Moser, André, Johannes Möller, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Veronika Gassenmeier, George Adrian Ifrim, Björn Frahm, Ralf Pörtner und Volker C. Hass. 2021. <i>Model-assisted Design of Experiments - Concept, Software and Applications</i>.","short":"A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-Assisted Design of Experiments - Concept, Software and Applications, 2021."}},{"keyword":["clonal cell population","phenotypic diversity","inoculum train","uncertainty-based","cell culture model","biopharmaceutical manufacturing"],"language":[{"iso":"eng"}],"publication_identifier":{"eisbn":["978-3-0365-5209-5"],"issn":["2227-9717 "],"isbn":["978-3-0365-5210-1"]},"publication":"Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing","date_created":"2022-05-05T12:55:52Z","date_updated":"2023-08-16T09:17:50Z","year":"2021","author":[{"id":"52466","last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja"},{"full_name":"Morerod, Sophie","first_name":"Sophie","last_name":"Morerod"},{"first_name":"Ralf","full_name":"Pörtner, Ralf","last_name":"Pörtner"},{"full_name":"Wurm, Florian M.","last_name":"Wurm","first_name":"Florian M."},{"first_name":"Björn","full_name":"Frahm, Björn","id":"45666","last_name":"Frahm"}],"status":"public","page":"49-74","title":"Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study","citation":{"ieee":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F. M. Wurm, and B. Frahm, “Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study,” in <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, vol. special issue, Basel: MDPI, 2021, pp. 49–74. doi: <a href=\"https://doi.org/10.3390/pr9060964\">10.3390/pr9060964</a>.","ama":"Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>. Vol special issue. Processes : open access journal . MDPI; 2021:49-74. doi:<a href=\"https://doi.org/10.3390/pr9060964\">10.3390/pr9060964</a>","apa":"Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., &#38; Frahm, B. (2021). Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue</i> (pp. 49–74). MDPI. <a href=\"https://doi.org/10.3390/pr9060964\">https://doi.org/10.3390/pr9060964</a>","chicago":"Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm, and Björn Frahm. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study.” In <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, special issue:49–74. Processes : Open Access Journal . Basel: MDPI, 2021. <a href=\"https://doi.org/10.3390/pr9060964\">https://doi.org/10.3390/pr9060964</a>.","van":"Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2021. p. 49–74. (Processes : open access journal ; vol. special issue).","ufg":"<b>Hernández Rodriguez, Tanja u. a.</b>: Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: o. Hg.: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Band <i>special issue</i>, Basel 2021 (Processes : open access journal ),  S. 49–74.","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (2021) Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study. <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, vol. special issue. Basel: MDPI, pp. 49–74.","mla":"Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study.” <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, vol. special issue, MDPI, 2021, pp. 49–74, <a href=\"https://doi.org/10.3390/pr9060964\">https://doi.org/10.3390/pr9060964</a>.","havard":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021: pp. 49–74.","short":"T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021, pp. 49–74.","chicago-de":"Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm und Björn Frahm. 2021. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, special issue:49–74. Processes : open access journal . Basel: MDPI. doi:<a href=\"https://doi.org/10.3390/pr9060964\">10.3390/pr9060964</a>, .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Morerod, Sophie</span> ; <span style=\"font-variant:small-caps;\">Pörtner, Ralf</span> ; <span style=\"font-variant:small-caps;\">Wurm, Florian M.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: <i>Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing</i>, <i>Processes : open access journal </i>. Bd. special issue. Basel : MDPI, 2021, S. 49–74"},"volume":"special issue","_id":"7983","doi":"10.3390/pr9060964","place":"Basel","type":"book_chapter","user_id":"83781","abstract":[{"text":"For the manufacturing of complex biopharmaceuticals using bioreactors with cultivated mammalian cells, high product concentration is an important objective. The phenotype of the cells in a reactor plays an important role. Are clonal cell populations showing high cell-specific growth rates more favorable than cell lines with higher cell-specific productivities or vice versa? Five clonal Chinese hamster ovary cell populations were analyzed based on the data of a 3-month-stability study. We adapted a mechanistic cell culture model to the experimental data of one such clonally derived cell population. Uncertainties and prior knowledge concerning model parameters were considered using Bayesian parameter estimations. This model was used then to define an inoculum train protocol. Based on this, we subsequently simulated the impacts of differences in growth rates (±10%) and production rates (±10% and ±50%) on the overall cultivation time, including making the inoculum train cultures; the final production phase, the volumetric titer in that bioreactor and the ratio of both, defined as overall process productivity. We showed thus unequivocally that growth rates have a higher impact (up to three times) on overall process productivity and for product output per year, whereas cells with higher productivity can potentially generate higher product concentrations in the production vessel.","lang":"eng"}],"department":[{"_id":"DEP4021"}],"publisher":"MDPI","quality_controlled":"1","series_title":"Processes : open access journal ","publication_status":"published"},{"date_updated":"2023-08-21T07:51:38Z","publication":"Bioprocess and Biosystems Engineering","publication_identifier":{"eissn":["1615-7605"],"issn":["1615-7591"]},"date_created":"2022-05-05T13:06:12Z","keyword":["Dynamic parameter estimation","Bioprocess","Cell cultures","Moving horizon estimation","Prior knowledge"],"language":[{"iso":"eng"}],"citation":{"ama":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. <i>Bioprocess and Biosystems Engineering</i>. 2021;44(4):793-808. doi:<a href=\"https://doi.org/10.1007/s00449-020-02488-1 \">10.1007/s00449-020-02488-1 </a>","ieee":"T. Hernández Rodriguez, C. Posch, R. Pörtner, and B. Frahm, “Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train,” <i>Bioprocess and Biosystems Engineering</i>, vol. 44, no. 4, pp. 793–808, 2021, doi: <a href=\"https://doi.org/10.1007/s00449-020-02488-1 \">10.1007/s00449-020-02488-1 </a>.","chicago-de":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner und Björn Frahm. 2021. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. <i>Bioprocess and Biosystems Engineering</i> 44, Nr. 4: 793–808. doi:<a href=\"https://doi.org/10.1007/s00449-020-02488-1 \">10.1007/s00449-020-02488-1 </a>, .","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Posch, Christoph</span> ; <span style=\"font-variant:small-caps;\">Pörtner, Ralf</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. In: <i>Bioprocess and Biosystems Engineering</i> Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 793–808","short":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Bioprocess and Biosystems Engineering 44 (2021) 793–808.","ufg":"<b>Hernández Rodriguez, Tanja u. a.</b>: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, in: <i>Bioprocess and Biosystems Engineering</i> 44 (2021), H. 4,  S. 793–808.","mla":"Hernández Rodriguez, Tanja, et al. “Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train.” <i>Bioprocess and Biosystems Engineering</i>, vol. 44, no. 4, 2021, pp. 793–808, <a href=\"https://doi.org/10.1007/s00449-020-02488-1 \">https://doi.org/10.1007/s00449-020-02488-1 </a>.","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (2021) Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train. <i>Bioprocess and Biosystems Engineering</i> <b>44</b>, 793–808.","havard":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, Bioprocess and Biosystems Engineering. 44 (2021) 793–808.","van":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering. 2021;44(4):793–808.","chicago":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, and Björn Frahm. “Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train.” <i>Bioprocess and Biosystems Engineering</i> 44, no. 4 (2021): 793–808. <a href=\"https://doi.org/10.1007/s00449-020-02488-1 \">https://doi.org/10.1007/s00449-020-02488-1 </a>.","apa":"Hernández Rodriguez, T., Posch, C., Pörtner, R., &#38; Frahm, B. (2021). Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. <i>Bioprocess and Biosystems Engineering</i>, <i>44</i>(4), 793–808. <a href=\"https://doi.org/10.1007/s00449-020-02488-1 \">https://doi.org/10.1007/s00449-020-02488-1 </a>"},"volume":44,"title":"Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train","status":"public","page":"793-808","year":"2021","author":[{"full_name":"Hernández Rodriguez, Tanja","id":"52466","last_name":"Hernández Rodriguez","first_name":"Tanja"},{"last_name":"Posch","first_name":"Christoph","full_name":"Posch, Christoph"},{"last_name":"Pörtner","full_name":"Pörtner, Ralf","first_name":"Ralf"},{"full_name":"Frahm, Björn","first_name":"Björn","last_name":"Frahm","id":"45666"}],"user_id":"83781","intvolume":"        44","type":"scientific_journal_article","place":"Berlin ; Heidelberg [u.a.]","_id":"7985","doi":"10.1007/s00449-020-02488-1 ","publication_status":"published","publisher":"Springer","quality_controlled":"1","department":[{"_id":"DEP4021"}],"abstract":[{"text":"Bioprocess modeling has become a useful tool for prediction of the process future with the aim to deduce operating decisions (e.g. transfer or feeds). Due to variabilities, which often occur between and within batches, updating (re-estimation) of model parameters is required at certain time intervals (dynamic parameter estimation) to obtain reliable predictions. This can be challenging in the presence of low sampling frequencies (e.g. every 24 h), different consecutive scales and large measurement errors, as in the case of cell culture seed trains. This contribution presents an iterative learning workflow which generates and incorporates knowledge concerning cell growth during the process by using a moving horizon estimation (MHE) approach for updating of model parameters. This estimation technique is compared to a classical weighted least squares estimation (WLSE) approach in the context of model updating over three consecutive cultivation scales (40–2160 L) of an industrial cell culture seed train. Both techniques were investigated regarding robustness concerning the aforementioned challenges and the required amount of experimental data (estimation horizon). It is shown how the proposed MHE can deal with the aforementioned difficulties by the integration of prior knowledge, even if only data at two sampling points are available, outperforming the classical WLSE approach. This workflow allows to adequately integrate current process behavior into the model and can therefore be a suitable component of a digital twin.","lang":"eng"}],"issue":"4"},{"publication_status":"published","publisher":"Springer","quality_controlled":"1","department":[{"_id":"DEP4021"}],"issue":"4","abstract":[{"lang":"eng","text":"Bioprocess development and optimization are still cost- and time-intensive due to the enormous number of experiments involved. In this study, the recently introduced model-assisted Design of Experiments (mDoE) concept (Möller et al. in Bioproc Biosyst Eng 42(5):867, https://doi.org/10.1007/s00449-019-02089-7, 2019) was extended and implemented into a software (“mDoE-toolbox”) to significantly reduce the number of required cultivations. The application of the toolbox is exemplary shown in two case studies with Saccharomyces cerevisiae. In the first case study, a fed-batch process was optimized with respect to the pH value and linearly rising feeding rates of glucose and nitrogen source. Using the mDoE-toolbox, the biomass concentration was increased by 30% compared to previously performed experiments. The second case study was the whole-cell biocatalysis of ethyl acetoacetate (EAA) to (S)-ethyl-3-hydroxybutyrate (E3HB), for which the feeding rates of glucose, nitrogen source, and EAA were optimized. An increase of 80% compared to a previously performed experiment with similar initial conditions was achieved for the E3HB concentration."}],"user_id":"83781","intvolume":"        44","type":"scientific_journal_article","place":"Berlin ; Heidelberg [u.a.]","_id":"7986","doi":"10.1007/s00449-020-02478-3","citation":{"van":"Moser A, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Frahm B, Pörtner R, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering. 2021;44(4):683–700.","ufg":"<b>Moser, André u. a.</b>: Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, in: <i>Bioprocess and Biosystems Engineering</i> 44 (2021), H. 4,  S. 683–700.","havard":"A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, Bioprocess and Biosystems Engineering. 44 (2021) 683–700.","mla":"Moser, André, et al. “Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses.” <i>Bioprocess and Biosystems Engineering</i>, vol. 44, no. 4, 2021, pp. 683–700, <a href=\"https://doi.org/10.1007/s00449-020-02478-3\">https://doi.org/10.1007/s00449-020-02478-3</a>.","bjps":"<b>Moser A <i>et al.</i></b> (2021) Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses. <i>Bioprocess and Biosystems Engineering</i> <b>44</b>, 683–700.","apa":"Moser, A., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Frahm, B., Pörtner, R., Hass, V. C., &#38; Möller, J. (2021). Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. <i>Bioprocess and Biosystems Engineering</i>, <i>44</i>(4), 683–700. <a href=\"https://doi.org/10.1007/s00449-020-02478-3\">https://doi.org/10.1007/s00449-020-02478-3</a>","chicago":"Moser, André, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Björn Frahm, Ralf Pörtner, Volker C. Hass, and Johannes Möller. “Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses.” <i>Bioprocess and Biosystems Engineering</i> 44, no. 4 (2021): 683–700. <a href=\"https://doi.org/10.1007/s00449-020-02478-3\">https://doi.org/10.1007/s00449-020-02478-3</a>.","short":"A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Bioprocess and Biosystems Engineering 44 (2021) 683–700.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Moser, André</span> ; <span style=\"font-variant:small-caps;\">Kuchemüller, Kim B.</span> ; <span style=\"font-variant:small-caps;\">Deppe, Sahar</span> ; <span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Pörtner, Ralf</span> ; <span style=\"font-variant:small-caps;\">Hass, Volker C.</span> ; <span style=\"font-variant:small-caps;\">Möller, Johannes</span>: Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. In: <i>Bioprocess and Biosystems Engineering</i> Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 683–700","chicago-de":"Moser, André, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Björn Frahm, Ralf Pörtner, Volker C. Hass und Johannes Möller. 2021. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. <i>Bioprocess and Biosystems Engineering</i> 44, Nr. 4: 683–700. doi:<a href=\"https://doi.org/10.1007/s00449-020-02478-3\">10.1007/s00449-020-02478-3</a>, .","ama":"Moser A, Kuchemüller KB, Deppe S, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. <i>Bioprocess and Biosystems Engineering</i>. 2021;44(4):683-700. doi:<a href=\"https://doi.org/10.1007/s00449-020-02478-3\">10.1007/s00449-020-02478-3</a>","ieee":"A. Moser <i>et al.</i>, “Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses,” <i>Bioprocess and Biosystems Engineering</i>, vol. 44, no. 4, pp. 683–700, 2021, doi: <a href=\"https://doi.org/10.1007/s00449-020-02478-3\">10.1007/s00449-020-02478-3</a>."},"volume":44,"title":"Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses","status":"public","page":"683-700","author":[{"first_name":"André","last_name":"Moser","full_name":"Moser, André"},{"last_name":"Kuchemüller","first_name":"Kim B.","full_name":"Kuchemüller, Kim B."},{"full_name":"Deppe, Sahar","first_name":"Sahar","last_name":"Deppe"},{"last_name":"Hernández Rodriguez","full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja","id":"52466"},{"first_name":"Björn","last_name":"Frahm","full_name":"Frahm, Björn","id":"45666"},{"full_name":"Pörtner, Ralf","last_name":"Pörtner","first_name":"Ralf"},{"full_name":"Hass, Volker C.","first_name":"Volker C.","last_name":"Hass"},{"first_name":"Johannes","full_name":"Möller, Johannes","last_name":"Möller"}],"year":"2021","date_updated":"2023-08-21T07:55:05Z","publication_identifier":{"eissn":["1615-7605"],"isbn":["1615-7591"]},"publication":"Bioprocess and Biosystems Engineering","date_created":"2022-05-05T13:10:11Z","keyword":["Biocatalysis","Monte Carlo methods","Fed-batch strategy","Model-assisted design of experiments","Quality by design"],"language":[{"iso":"eng"}]},{"status":"public","page":"97–131","author":[{"full_name":"Hernández Rodriguez, Tanja","id":"52466","last_name":"Hernández Rodriguez","first_name":"Tanja"},{"first_name":"Björn","id":"45666","full_name":"Frahm, Björn","last_name":"Frahm"}],"year":"2021","citation":{"apa":"Hernández Rodriguez, T., &#38; Frahm, B. (2021). Digital Seed Train Twins and Statistical Methods. In C. Herwig, R. Pörtner, &#38; J. Möller (Eds.), <i>Digital Twins Tools and Concepts for Smart Biomanufacturing</i> (Vol. 176, pp. 97–131). Springer. <a href=\"https://doi.org/10.1007/10_2020_137\">https://doi.org/10.1007/10_2020_137</a>","chicago":"Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins and Statistical Methods.” In <i>Digital Twins Tools and Concepts for Smart Biomanufacturing</i>, edited by Christoph  Herwig, Ralf  Pörtner, and Johannes  Möller, 176:97–131. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer, 2021. <a href=\"https://doi.org/10.1007/10_2020_137\">https://doi.org/10.1007/10_2020_137</a>.","van":"Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, editors. Digital Twins Tools and Concepts for Smart Biomanufacturing. Berlin, Heidelberg: Springer; 2021. p. 97–131. (Advances in Biochemical Engineering/Biotechnology; vol. 176).","ufg":"<b>Hernández Rodriguez, Tanja/Frahm, Björn</b>: Digital Seed Train Twins and Statistical Methods, in: <i>Herwig, Christoph/Pörtner, Ralf/Möller, Johannes (Hgg.)</i>: Digital Twins Tools and Concepts for Smart Biomanufacturing, Bd. 176, Berlin, Heidelberg 2021 (Advances in Biochemical Engineering/Biotechnology),  S. 97–131.","bjps":"<b>Hernández Rodriguez T and Frahm B</b> (2021) Digital Seed Train Twins and Statistical Methods. In Herwig C, Pörtner R and Möller J (eds), <i>Digital Twins Tools and Concepts for Smart Biomanufacturing</i>, vol. 176. Berlin, Heidelberg: Springer, pp. 97–131.","havard":"T. Hernández Rodriguez, B. Frahm, Digital Seed Train Twins and Statistical Methods, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021: pp. 97–131.","mla":"Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins and Statistical Methods.” <i>Digital Twins Tools and Concepts for Smart Biomanufacturing</i>, edited by Christoph  Herwig et al., vol. 176, Springer, 2021, pp. 97–131, <a href=\"https://doi.org/10.1007/10_2020_137\">https://doi.org/10.1007/10_2020_137</a>.","short":"T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021, pp. 97–131.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: Digital Seed Train Twins and Statistical Methods. In: <span style=\"font-variant:small-caps;\">Herwig, C.</span> ; <span style=\"font-variant:small-caps;\">Pörtner, R.</span> ; <span style=\"font-variant:small-caps;\">Möller, J.</span> (Hrsg.): <i>Digital Twins Tools and Concepts for Smart Biomanufacturing</i>, <i>Advances in Biochemical Engineering/Biotechnology</i>. Bd. 176. Berlin, Heidelberg : Springer, 2021, S. 97–131","chicago-de":"Hernández Rodriguez, Tanja und Björn Frahm. 2021. Digital Seed Train Twins and Statistical Methods. In: <i>Digital Twins Tools and Concepts for Smart Biomanufacturing</i>, hg. von Christoph  Herwig, Ralf  Pörtner, und Johannes  Möller, 176:97–131. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer. doi:<a href=\"https://doi.org/10.1007/10_2020_137\">https://doi.org/10.1007/10_2020_137</a>, .","ieee":"T. Hernández Rodriguez and B. Frahm, “Digital Seed Train Twins and Statistical Methods,” in <i>Digital Twins Tools and Concepts for Smart Biomanufacturing</i>, vol. 176, C. Herwig, R. Pörtner, and J. Möller, Eds. Berlin, Heidelberg: Springer, 2021, pp. 97–131. doi: <a href=\"https://doi.org/10.1007/10_2020_137\">https://doi.org/10.1007/10_2020_137</a>.","ama":"Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, eds. <i>Digital Twins Tools and Concepts for Smart Biomanufacturing</i>. Vol 176. Advances in Biochemical Engineering/Biotechnology. Springer; 2021:97-131. doi:<a href=\"https://doi.org/10.1007/10_2020_137\">https://doi.org/10.1007/10_2020_137</a>"},"volume":176,"title":"Digital Seed Train Twins and Statistical Methods","keyword":["Bayes","Digital twin","Parameter estimation","Seed train","Uncertainty"],"language":[{"iso":"eng"}],"editor":[{"first_name":"Christoph ","last_name":"Herwig","full_name":"Herwig, Christoph "},{"full_name":"Pörtner, Ralf ","first_name":"Ralf ","last_name":"Pörtner"},{"first_name":"Johannes ","last_name":"Möller","full_name":"Möller, Johannes "}],"date_updated":"2023-08-16T06:48:35Z","publication_identifier":{"issn":["0724-6145"],"eisbn":["978-3-030-71660-8"],"isbn":["978-3-030-71659-2"],"eissn":["1616-8542"]},"publication":"Digital Twins Tools and Concepts for Smart Biomanufacturing","date_created":"2020-08-19T07:14:11Z","publisher":"Springer","quality_controlled":"1","abstract":[{"text":"Model-based concepts and simulation techniques in combination with digital tools emerge as a key to explore the full potential of biopharmaceutical production processes, which contain several challenging development and process steps. One of these steps is the time- and cost-intensive cell proliferation process (also called seed train) to increase cell number from cell thawing up to production scale. Challenges like complex cell metabolism, batch-to-batch variation, variabilities in cell behavior, and influences of changes in cultivation conditions necessitate adequate digital solutions to provide information about the current and near future process state to derive correct process decisions.\r\nFor this purpose digital seed train twins have proved to be efficient, which digitally display the time-dependent behavior of important process variables based on mathematical models, strategies, and adaption procedures.\r\nThis chapter will outline the needs for digitalization of seed trains, the construction of a digital seed train twin, the role of parameter estimation, and different statistical methods within this context, which are applicable to several problems in the field of bioprocessing. The results of a case study are presented to illustrate a Bayesian approach for parameter estimation and prediction of an industrial cell culture seed train for seed train digitalization.","lang":"eng"}],"department":[{"_id":"DEP4021"}],"publication_status":"published","series_title":"Advances in Biochemical Engineering/Biotechnology","_id":"3349","doi":"https://doi.org/10.1007/10_2020_137","place":"Berlin, Heidelberg","intvolume":"       176","user_id":"83781","type":"book_chapter"},{"_id":"7929","language":[{"iso":"eng"}],"date_updated":"2023-03-15T13:50:12Z","user_id":"45673","date_created":"2022-05-04T19:22:33Z","type":"conference_poster","status":"public","department":[{"_id":"DEP4021"}],"conference":{"name":"10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020","location":"als Web-Konferenz, Aachen, Germany","start_date":"2020-09-21","end_date":"2020-09-24"},"year":2020,"author":[{"id":"52466","last_name":"Hernández Rodriguez","first_name":"Tanja","full_name":"Hernández Rodriguez, Tanja"},{"first_name":"Sahar","last_name":"Deppe","full_name":"Deppe, Sahar"},{"first_name":"Veronika","id":"74048","last_name":"Gassenmeier","full_name":"Gassenmeier, Veronika"},{"full_name":"Kuhfuß, Fabian","first_name":"Fabian","last_name":"Kuhfuß"},{"full_name":"Tölle, Marius","first_name":"Marius","last_name":"Tölle"},{"first_name":"George Adrian","last_name":"Ifrim","id":"73814","full_name":"Ifrim, George Adrian"},{"full_name":"Frahm, Björn","id":"45666","last_name":"Frahm","first_name":"Björn"}],"citation":{"ufg":"<b>Hernández Rodriguez, Tanja et. al. (2020)</b>: Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration.","mla":"Hernández Rodriguez, Tanja, et al. <i>Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration</i>. 2020.","havard":"T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020.","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (2020) <i>Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration</i>. .","van":"Hernández Rodriguez T, Deppe S, Gassenmeier V, Kuhfuß F, Tölle M, Ifrim GA, et al. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020.","ama":"Hernández Rodriguez T, Deppe S, Gassenmeier V, et al. <i>Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration</i>.; 2020.","chicago":"Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim, and Björn Frahm. <i>Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration</i>, 2020.","apa":"Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., &#38; Frahm, B. (2020). <i>Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration</i>. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.","ieee":"T. Hernández Rodriguez <i>et al.</i>, <i>Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration</i>. 2020.","chicago-de":"Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim und Björn Frahm. 2020. <i>Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration</i>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Deppe, Sahar</span> ; <span style=\"font-variant:small-caps;\">Gassenmeier, Veronika</span> ; <span style=\"font-variant:small-caps;\">Kuhfuß, Fabian</span> ; <span style=\"font-variant:small-caps;\">Tölle, Marius</span> ; <span style=\"font-variant:small-caps;\">Ifrim, George Adrian</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration</i>, 2020","short":"T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020."},"title":"Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration"},{"title":"Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes","citation":{"apa":"Hernández Rodriguez, T., Posch, C., Pörtner, R., &#38; Frahm, B. (2020). <i>Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes</i>. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.","chicago":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, and Björn Frahm. <i>Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes</i>, 2020.","van":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. 2020.","havard":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020.","bjps":"<b>Hernández Rodriguez T <i>et al.</i></b> (2020) <i>Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes</i>. .","mla":"Hernández Rodriguez, Tanja, et al. <i>Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes</i>. 2020.","ufg":"<b>Hernández Rodriguez, Tanja et. al. (2020)</b>: Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes.","short":"T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Posch, Christoph</span> ; <span style=\"font-variant:small-caps;\">Pörtner, Ralf</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes</i>, 2020","chicago-de":"Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner und Björn Frahm. 2020. <i>Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes</i>.","ieee":"T. Hernández Rodriguez, C. Posch, R. Pörtner, and B. Frahm, <i>Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes</i>. 2020.","ama":"Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. <i>Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes</i>.; 2020."},"year":2020,"author":[{"full_name":"Hernández Rodriguez, Tanja","id":"52466","first_name":"Tanja","last_name":"Hernández Rodriguez"},{"full_name":"Posch, Christoph","first_name":"Christoph","last_name":"Posch"},{"last_name":"Pörtner","full_name":"Pörtner, Ralf","first_name":"Ralf"},{"last_name":"Frahm","full_name":"Frahm, Björn","id":"45666","first_name":"Björn"}],"department":[{"_id":"DEP4021"}],"conference":{"name":"10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020","location":"als Web-Konferenz, Aachen, Germany","start_date":"2020-09-21","end_date":"2020-09-24"},"status":"public","type":"conference_poster","date_created":"2022-05-04T19:26:13Z","user_id":"45666","date_updated":"2023-03-15T13:50:12Z","_id":"7930","language":[{"iso":"eng"}]},{"title":"Integration of prior knowledge and digital tools for uncertainty-based decision support","citation":{"ama":"Hernández Rodriguez T, Frahm B, Posch C. <i>Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support</i>.; 2020.","ieee":"T. Hernández Rodriguez, B. Frahm, and C. Posch, <i>Integration of prior knowledge and digital tools for uncertainty-based decision support</i>. 2020.","bjps":"<b>Hernández Rodriguez T, Frahm B and Posch C</b> (2020) <i>Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support</i>. .","havard":"T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020.","mla":"Hernández Rodriguez, Tanja, et al. <i>Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support</i>. 2020.","ufg":"<b>Hernández Rodriguez, Tanja et. al. (2020)</b>: Integration of prior knowledge and digital tools for uncertainty-based decision support.","van":"Hernández Rodriguez T, Frahm B, Posch C. Integration of prior knowledge and digital tools for uncertainty-based decision support. 2020.","chicago":"Hernández Rodriguez, Tanja, Björn Frahm, and Christoph Posch. <i>Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support</i>, 2020.","apa":"Hernández Rodriguez, T., Frahm, B., &#38; Posch, C. (2020). <i>Integration of prior knowledge and digital tools for uncertainty-based decision support</i>. Presented at the 1st TRD (Technical Research &#38; Development) Virtual Academia Strategic Roundtable, Sandoz, Austria.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span> ; <span style=\"font-variant:small-caps;\">Posch, Christoph</span>: <i>Integration of prior knowledge and digital tools for uncertainty-based decision support</i>, 2020","chicago-de":"Hernández Rodriguez, Tanja, Björn Frahm und Christoph Posch. 2020. <i>Integration of prior knowledge and digital tools for uncertainty-based decision support</i>.","short":"T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support, 2020."},"year":2020,"author":[{"first_name":"Tanja","last_name":"Hernández Rodriguez","id":"52466","full_name":"Hernández Rodriguez, Tanja"},{"first_name":"Björn","id":"45666","last_name":"Frahm","full_name":"Frahm, Björn"},{"full_name":"Posch, Christoph","last_name":"Posch","first_name":"Christoph"}],"conference":{"location":"Sandoz, Austria","name":"1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable","start_date":"2020-06-03"},"department":[{"_id":"DEP4021"}],"status":"public","type":"conference_speech","date_created":"2022-05-04T19:47:05Z","user_id":"45666","date_updated":"2023-03-15T13:50:12Z","language":[{"iso":"eng"}],"_id":"7936"},{"_id":"7937","doi":"10.1002/cite.202055235","language":[{"iso":"eng"}],"user_id":"45673","date_updated":"2023-03-15T13:50:12Z","publication":"Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020","date_created":"2022-05-04T19:59:48Z","type":"conference_editor_article","publisher":"Wiley","status":"public","page":"1225 – 1226","author":[{"full_name":"Hernández Rodriguez, Tanja","first_name":"Tanja","last_name":"Hernández Rodriguez","id":"52466"},{"full_name":"Deppe, Sahar","last_name":"Deppe","first_name":"Sahar"},{"full_name":"Gassenmeier, Veronika","last_name":"Gassenmeier","id":"74048","first_name":"Veronika"},{"last_name":"Kuhfuß","full_name":"Kuhfuß, Fabian","first_name":"Fabian"},{"first_name":"Marius","full_name":"Tölle, Marius","last_name":"Tölle"},{"first_name":"George Adrian","id":"73814","last_name":"Ifrim","full_name":"Ifrim, George Adrian"},{"full_name":"Frahm, Björn","id":"45666","first_name":"Björn","last_name":"Frahm"}],"year":2020,"department":[{"_id":"DEP4021"}],"volume":"No. 9","citation":{"ieee":"T. Hernández Rodriguez <i>et al.</i>, <i>Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration</i>, vol. No. 9. Wiley, 2020, pp. 1225 – 1226.","ama":"Hernández Rodriguez T, Deppe S, Gassenmeier V, et al. <i>Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration</i>. Vol No. 9. Wiley; 2020:1225 – 1226. doi:<a href=\"https://doi.org/10.1002/cite.202055235\">10.1002/cite.202055235</a>","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Deppe, Sahar</span> ; <span style=\"font-variant:small-caps;\">Gassenmeier, Veronika</span> ; <span style=\"font-variant:small-caps;\">Kuhfuß, Fabian</span> ; <span style=\"font-variant:small-caps;\">Tölle, Marius</span> ; <span style=\"font-variant:small-caps;\">Ifrim, George Adrian</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration</i>, <i>Volume 92</i>. Bd. No. 9 : Wiley, 2020","chicago-de":"Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim und Björn Frahm. 2020. <i>Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration</i>. <i>Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020</i>. Bd. No. 9. Volume 92. Wiley. doi:<a href=\"https://doi.org/10.1002/cite.202055235,\">10.1002/cite.202055235,</a> .","short":"T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration, Wiley, 2020.","chicago":"Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim, and Björn Frahm. <i>Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration</i>. <i>Chemie Ingenieur Technik, Tagungsband Zur 10. ProcessNet-Jahrestagung Und 34. DECHEMA-Jahrestagung Der Biotechnologen 2020</i>. Vol. No. 9. Volume 92. Wiley, 2020. <a href=\"https://doi.org/10.1002/cite.202055235\">https://doi.org/10.1002/cite.202055235</a>.","apa":"Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., &#38; Frahm, B. (2020). <i>Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration</i>. <i>Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. 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Frahm, <i>Seed train optimization for suspension cell culture</i>. 2013.","apa":"Hernández Rodriguez, T., Pörtner, R., &#38; Frahm, B. (2013). <i>Seed train optimization for suspension cell culture</i>. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.","chicago-de":"Hernández Rodriguez, Tanja, R. Pörtner und Björn Frahm. 2013. <i>Seed train optimization for suspension cell culture</i>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Hernández Rodriguez, Tanja</span> ; <span style=\"font-variant:small-caps;\">Pörtner, R.</span> ; <span style=\"font-variant:small-caps;\">Frahm, Björn</span>: <i>Seed train optimization for suspension cell culture</i>, 2013","short":"T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, 2013."},"publication_status":"published"}]