--- _id: '13652' abstract: - lang: eng text: "Modellbasierte Konzepte und Simulationstechniken in Kombination mit digitalen Werkzeugen erweisen sich als Schlüssel, um das volle Potenzial biopharmazeutischer Produktionsprozesse zu erschließen, die mehrere herausfordernde Entwicklungs- und Prozessschritte enthalten. Einer dieser Schritte ist der zeit- und kostenintensive Zellproliferationsprozess (auch als Seed Train bezeichnet), um die Zellzahl vom Auftauen der Zellen bis zum Produktionsmaßstab zu erhöhen. Herausforderungen wie komplexer Zellstoffwechsel, Chargen-zu-Chargen-Variationen, Variabilitäten im Zellverhalten und Einflüsse von Änderungen der Kultivierungsbedingungen erfordern adäquate digitale Lösungen, um Informationen über den aktuellen und zukünftigen Prozesszustand bereitzustellen und korrekte Prozessentscheidungen abzuleiten.\r\n\r\nZu diesem Zweck haben sich digitale Seed Train Zwillinge als effizient erwiesen, die das zeitabhängige Verhalten wichtiger Prozessvariablen basierend auf mathematischen Modellen, Strategien und Anpassungsverfahren digital darstellen.\r\n\r\nDieses Kapitel skizziert die Notwendigkeit der Digitalisierung von Seed Trains, den Aufbau eines digitalen Seed Train Zwillings, die Rolle der Parameterschätzung und verschiedene statistische Methoden in diesem Zusammenhang, die auf mehrere Probleme im Bereich der Bioprozessierung anwendbar sind. Die Ergebnisse einer Fallstudie werden vorgestellt, um einen Bayes’schen Ansatz zur Parameterschätzung und Vorhersage eines industriellen Zellkultur-Seed Trains für die Seed Train Digitalisierung zu veranschaulichen." author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: 'Hernández Rodriguez T, Frahm B. Digitale Seed Train Zwillinge und statistische Methoden. In: Herwig C, Pörtner R, Möller J, eds. Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion. Advances in Biochemical Engineering/Biotechnology. Springer ; 2025:107-145. doi:https://doi.org/10.1007/978-3-031-75698-6_5' apa: Hernández Rodriguez, T., & Frahm, B. (2025). Digitale Seed Train Zwillinge und statistische Methoden. In C. Herwig, R. Pörtner, & J. Möller (Eds.), Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion (pp. 107–145). Springer . https://doi.org/10.1007/978-3-031-75698-6_5 bjps: 'Hernández Rodriguez T and Frahm B (2025) Digitale Seed Train Zwillinge und statistische Methoden. In Herwig C, Pörtner R and Möller J (eds), Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion. Berlin, Heidelberg: Springer , pp. 107–145.' chicago: 'Hernández Rodriguez, Tanja, and Björn Frahm. “Digitale Seed Train Zwillinge und statistische Methoden.” In Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, edited by Christoph Herwig, Ralf Pörtner, and Johannes Möller, 107–45. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer , 2025. https://doi.org/10.1007/978-3-031-75698-6_5.' chicago-de: 'Hernández Rodriguez, Tanja und Björn Frahm. 2025. Digitale Seed Train Zwillinge und statistische Methoden. In: Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, hg. von Christoph Herwig, Ralf Pörtner, und Johannes Möller, 107–145. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer . doi:https://doi.org/10.1007/978-3-031-75698-6_5, .' din1505-2-1: 'Hernández Rodriguez, Tanja ; Frahm, Björn: Digitale Seed Train Zwillinge und statistische Methoden. In: Herwig, C. ; Pörtner, R. ; Möller, J. (Hrsg.): Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg : Springer , 2025, S. 107–145' havard: 'T. Hernández Rodriguez, B. Frahm, Digitale Seed Train Zwillinge und statistische Methoden, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, Springer , Berlin, Heidelberg, 2025: pp. 107–145.' ieee: 'T. Hernández Rodriguez and B. Frahm, “Digitale Seed Train Zwillinge und statistische Methoden,” in Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, C. Herwig, R. Pörtner, and J. Möller, Eds. Berlin, Heidelberg: Springer , 2025, pp. 107–145. doi: https://doi.org/10.1007/978-3-031-75698-6_5.' mla: Hernández Rodriguez, Tanja, and Björn Frahm. “Digitale Seed Train Zwillinge und statistische Methoden.” Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, edited by Christoph Herwig et al., Springer , 2025, pp. 107–45, https://doi.org/10.1007/978-3-031-75698-6_5. short: 'T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, Springer , Berlin, Heidelberg, 2025, pp. 107–145.' ufg: 'Hernández Rodriguez, Tanja/Frahm, Björn: Digitale Seed Train Zwillinge und statistische Methoden, in: Herwig, Christoph/Pörtner, Ralf/Möller, Johannes (Hgg.): Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion, Berlin, Heidelberg 2025 (Advances in Biochemical Engineering/Biotechnology), S. 107–145.' van: 'Hernández Rodriguez T, Frahm B. Digitale Seed Train Zwillinge und statistische Methoden. In: Herwig C, Pörtner R, Möller J, editors. Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion. Berlin, Heidelberg: Springer ; 2025. p. 107–45. (Advances in Biochemical Engineering/Biotechnology).' date_created: 2026-03-27T17:45:02Z date_updated: 2026-04-08T12:46:45Z department: - _id: DEP4000 doi: https://doi.org/10.1007/978-3-031-75698-6_5 editor: - first_name: Christoph full_name: Herwig, Christoph last_name: Herwig - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Johannes full_name: Möller, Johannes last_name: Möller keyword: - Bayes - Digitaler Zwilling - Parameterabschätzung - Seed-Train - Unsicherheit language: - iso: ger page: 107-145 place: Berlin, Heidelberg publication: Digitale Zwillinge - Werkzeuge und Konzepte für intelligente Bioproduktion publication_identifier: eisbn: - 978-3-031-75698-6 isbn: - 978-3-031-75697-9 publication_status: published publisher: 'Springer ' quality_controlled: '1' series_title: Advances in Biochemical Engineering/Biotechnology status: public title: Digitale Seed Train Zwillinge und statistische Methoden type: book_chapter user_id: '83781' year: '2025' ... --- _id: '12402' abstract: - lang: eng text: In anaerobic technology, pH values are crucial for targeted volatile fatty acid production. While pH dynamics can be modeled using the Anaerobic Digestion Model No. 1 (ADM1), simulation results may be biased. To address this issue, the pH prediction routine of Visual Water, a specialized water chemistry simulator, was validated. Unlike ADM1, it accounts for ionic strength and activities while also providing an automated uncertainty analysis. The analysis revealed Visual Water simulations to better fit measured pH data from acidic solutions in a miniaturized stirred-tank reactor. author: - first_name: Pascal full_name: Kosse, Pascal last_name: Kosse - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Manfred full_name: Lübken, Manfred last_name: Lübken - first_name: Marc full_name: Wichern, Marc last_name: Wichern citation: ama: Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik. 2024;96(4):528-534. doi:10.1002/cite.202300188 apa: Kosse, P., Hernández Rodriguez, T., Frahm, B., Lübken, M., & Wichern, M. (2024). Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik, 96(4), 528–534. https://doi.org/10.1002/cite.202300188 bjps: Kosse P et al. (2024) Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik 96, 528–534. chicago: 'Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken, and Marc Wichern. “Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.” Chemie Ingenieur Technik 96, no. 4 (2024): 528–34. https://doi.org/10.1002/cite.202300188.' chicago-de: 'Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken und Marc Wichern. 2024. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik 96, Nr. 4: 528–534. doi:10.1002/cite.202300188, .' din1505-2-1: 'Kosse, Pascal ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Lübken, Manfred ; Wichern, Marc: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. In: Chemie Ingenieur Technik Bd. 96. Weinheim, Wiley (2024), Nr. 4, S. 528–534' havard: P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, Chemie Ingenieur Technik. 96 (2024) 528–534. ieee: 'P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, and M. Wichern, “Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator,” Chemie Ingenieur Technik, vol. 96, no. 4, pp. 528–534, 2024, doi: 10.1002/cite.202300188.' mla: Kosse, Pascal, et al. “Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.” Chemie Ingenieur Technik, vol. 96, no. 4, 2024, pp. 528–34, https://doi.org/10.1002/cite.202300188. short: P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 96 (2024) 528–534. ufg: 'Kosse, Pascal u. a.: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator, in: Chemie Ingenieur Technik 96 (2024), H. 4, S. 528–534.' van: Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator. Chemie Ingenieur Technik. 2024;96(4):528–34. date_created: 2025-01-29T13:49:16Z date_updated: 2025-06-25T12:42:09Z department: - _id: DEP4000 doi: 10.1002/cite.202300188 external_id: isi: - '001169606600001' intvolume: ' 96' isi: '1' issue: '4' keyword: - Anaerobic Digestion Model No. 1 (ADM1) - Anaerobic technology - pH simulation - Uncertainty assessment - Visual Water language: - iso: eng page: 528-534 place: Weinheim publication: Chemie Ingenieur Technik publication_identifier: eissn: - 1522-2640 issn: - 0009-286X publication_status: published publisher: Wiley quality_controlled: '1' status: public title: Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator type: scientific_journal_article user_id: '83781' volume: 96 year: '2024' ... --- _id: '11381' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Selina full_name: Ramm, Selina id: '68713' last_name: Ramm orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Markus full_name: Lange-Hegermann, Markus id: '71761' last_name: Lange-Hegermann - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V. apa: Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (n.d.). A systematic, model-based workflow for risk-based decision making in upstream development. 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Berlin, Germany. DECHEMA e.V. bjps: Hernández Rodriguez T et al. (n.d.) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V. chicago: Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann, and Björn Frahm. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V., n.d. chicago-de: Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann und Björn Frahm. A systematic, model-based workflow for risk-based decision making in upstream development. DECHEMA e.V. din1505-2-1: 'Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development : DECHEMA e.V.' havard: T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, DECHEMA e.V., n.d. ieee: T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, and B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development. DECHEMA e.V. mla: Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V. short: T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, DECHEMA e.V., n.d. ufg: 'Hernández Rodriguez, Tanja u. a.: A systematic, model-based workflow for risk-based decision making in upstream development, o. O. u. J. .' van: Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development. DECHEMA e.V.; conference: end_date: 2023-09-21 location: Berlin, Germany name: 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology start_date: 2023-09-17 date_created: 2024-04-26T06:18:20Z date_updated: 2024-08-02T13:57:27Z department: - _id: DEP4000 language: - iso: eng publication_status: accepted publisher: DECHEMA e.V. status: public title: A systematic, model-based workflow for risk-based decision making in upstream development type: conference_poster user_id: '83781' year: '2023' ... --- _id: '11382' author: - first_name: Veronika full_name: Gassenmeier, Veronika id: '74048' last_name: Gassenmeier - first_name: Fabian full_name: Kuhfuß, Fabian last_name: Kuhfuß - first_name: Sahar full_name: Deppe, Sahar last_name: Deppe - first_name: George full_name: Ifrim, George last_name: Ifrim - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Gassenmeier V, Kuhfuß F, Deppe S, Ifrim G, Hernández Rodriguez T, Frahm B. View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks. apa: Gassenmeier, V., Kuhfuß, F., Deppe, S., Ifrim, G., Hernández Rodriguez, T., & Frahm, B. (n.d.). View on a mechanistic model of Chlorella vulgaris in shake flasks. BioProcessingDays 2023, Recklinghausen, Germany. bjps: Gassenmeier V et al. (n.d.) View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks. . chicago: Gassenmeier, Veronika, Fabian Kuhfuß, Sahar Deppe, George Ifrim, Tanja Hernández Rodriguez, and Björn Frahm. View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks, n.d. chicago-de: Gassenmeier, Veronika, Fabian Kuhfuß, Sahar Deppe, George Ifrim, Tanja Hernández Rodriguez und Björn Frahm. View on a mechanistic model of Chlorella vulgaris in shake flasks. din1505-2-1: 'Gassenmeier, Veronika ; Kuhfuß, Fabian ; Deppe, Sahar ; Ifrim, George ; Hernández Rodriguez, Tanja ; Frahm, Björn: View on a mechanistic model of Chlorella vulgaris in shake flasks' havard: V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in shake flasks, n.d. ieee: V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, and B. Frahm, View on a mechanistic model of Chlorella vulgaris in shake flasks. mla: Gassenmeier, Veronika, et al. View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks. short: V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks, n.d. ufg: 'Gassenmeier, Veronika u. a.: View on a mechanistic model of Chlorella vulgaris in shake flasks, o. O. u. J. .' van: Gassenmeier V, Kuhfuß F, Deppe S, Ifrim G, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in shake flasks. conference: end_date: 20203-03-01 location: Recklinghausen, Germany name: BioProcessingDays 2023 start_date: 2023-02-27 date_created: 2024-04-26T06:22:50Z date_updated: 2025-01-29T13:42:42Z department: - _id: DEP4000 language: - iso: eng main_file_link: - open_access: '1' url: http://www.apz-rl.de/BioProcessingDays_2023/002_download/BPDs_2023_Tagungsbuch_Titel.pdf oa: '1' publication_status: accepted status: public title: View on a mechanistic model of Chlorella vulgaris in shake flasks type: conference_poster user_id: '45666' year: '2023' ... --- _id: '11383' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Christoph full_name: Posch, Christoph last_name: Posch - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Markus full_name: Lange-Hegermann, Markus id: '71761' last_name: Lange-Hegermann - first_name: Florian M. full_name: Wurm, Florian M. last_name: Wurm - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Posch C, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V.; 2023. apa: Hernández Rodriguez, T., Posch, C., Pörtner, R., Lange-Hegermann, M., Wurm, F. M., & Frahm, B. (2023). Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture. 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Berlin, Germany. DECHEMA e.V. bjps: Hernández Rodriguez T et al. (2023) Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V. chicago: Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, Markus Lange-Hegermann, Florian M. Wurm, and Björn Frahm. Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V., 2023. chicago-de: Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, Markus Lange-Hegermann, Florian M. Wurm und Björn Frahm. 2023. Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture. DECHEMA e.V. din1505-2-1: 'Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Lange-Hegermann, Markus ; Wurm, Florian M. ; Frahm, Björn: Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture : DECHEMA e.V., 2023' havard: T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture, DECHEMA e.V., 2023. ieee: T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F. M. Wurm, and B. Frahm, Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture. DECHEMA e.V., 2023. mla: Hernández Rodriguez, Tanja, et al. Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V., 2023. short: T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, DECHEMA e.V., 2023. ufg: 'Hernández Rodriguez, Tanja u. a.: Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture, o. O. 2023.' van: Hernández Rodriguez T, Posch C, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture. DECHEMA e.V.; 2023. conference: end_date: 2023-09-21 location: Berlin, Germany name: 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology start_date: 2023-09-17 date_created: 2024-04-26T06:40:20Z date_updated: 2024-05-21T09:06:45Z department: - _id: DEP4000 language: - iso: eng publication_status: published publisher: DECHEMA e.V. status: public title: Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture type: conference_speech user_id: '83781' year: '2023' ... --- _id: '11385' abstract: - lang: eng text: Accurate pH calculations are essential for scientists across different disciplines to design optimal reactor solutions, but they can be arduous to calculate for complex acid-base solutions. Visual Water is a powerful software tool that provides accurate pH calculations with automated mathematical uncertainty analysis. Its workflow is presented and validated using acids and bases, showing a deviation of < 0.2 pH units between measured and calculated pH values. This highlights the software's reliability, which can help to simplify the work of non-experts in water chemistry. author: - first_name: Pascal full_name: Kosse, Pascal last_name: Kosse - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Manfred full_name: Lübken, Manfred last_name: Lübken - first_name: Marc full_name: Wichern, Marc last_name: Wichern citation: ama: Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik. 2023;95(12):1960-1969. doi:10.1002/cite.202300082 apa: Kosse, P., Hernández Rodriguez, T., Frahm, B., Lübken, M., & Wichern, M. (2023). Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik, 95(12), 1960–1969. https://doi.org/10.1002/cite.202300082 bjps: Kosse P et al. (2023) Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations. Chemie Ingenieur Technik 95, 1960–1969. chicago: 'Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken, and Marc Wichern. “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations.” Chemie Ingenieur Technik 95, no. 12 (2023): 1960–69. https://doi.org/10.1002/cite.202300082.' chicago-de: 'Kosse, Pascal, Tanja Hernández Rodriguez, Björn Frahm, Manfred Lübken und Marc Wichern. 2023. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik 95, Nr. 12: 1960–1969. doi:10.1002/cite.202300082, .' din1505-2-1: 'Kosse, Pascal ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Lübken, Manfred ; Wichern, Marc: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. In: Chemie Ingenieur Technik Bd. 95. Weinheim, Wiley (2023), Nr. 12, S. 1960–1969' havard: P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, Chemie Ingenieur Technik. 95 (2023) 1960–1969. ieee: 'P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, and M. Wichern, “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations,” Chemie Ingenieur Technik, vol. 95, no. 12, pp. 1960–1969, 2023, doi: 10.1002/cite.202300082.' mla: Kosse, Pascal, et al. “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations.” Chemie Ingenieur Technik, vol. 95, no. 12, 2023, pp. 1960–69, https://doi.org/10.1002/cite.202300082. short: P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 95 (2023) 1960–1969. ufg: 'Kosse, Pascal u. a.: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations, in: Chemie Ingenieur Technik 95 (2023), H. 12, S. 1960–1969.' van: Kosse P, Hernández Rodriguez T, Frahm B, Lübken M, Wichern M. Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations. Chemie Ingenieur Technik. 2023;95(12):1960–9. date_created: 2024-04-26T06:52:48Z date_updated: 2025-06-26T07:50:29Z department: - _id: DEP4000 doi: 10.1002/cite.202300082 external_id: isi: - '001073579300001' intvolume: ' 95' isi: '1' issue: '12' keyword: - Acid-base equilibria - Carboxylic acids - Dissociation constants - pH calculation software - Uncertainty assessment language: - iso: eng page: 1960-1969 place: Weinheim publication: Chemie Ingenieur Technik publication_identifier: eissn: - 1522-2640 issn: - 0009-286X publication_status: published publisher: Wiley quality_controlled: '1' status: public title: Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations type: scientific_journal_article user_id: '83781' volume: 95 year: '2023' ... --- _id: '11487' author: - first_name: Selina full_name: Ramm, Selina id: '68713' last_name: Ramm orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V. apa: Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (n.d.). Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Berlin, Germany. DECHEMA e.V. bjps: Ramm S et al. (n.d.) Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V. chicago: Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm, and Miriam Pein-Hackelbusch. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V., n.d. chicago-de: Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V. din1505-2-1: 'Ramm, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression : DECHEMA e.V.' havard: S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression , DECHEMA e.V., n.d. ieee: S. Ramm, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V. mla: Ramm, Selina, et al. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V. short: S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression , DECHEMA e.V., n.d. ufg: 'Ramm, Selina u. a.: Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression , o. O. u. J. .' van: Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.; conference: end_date: 2023-09-21 location: Berlin, Germany name: 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology start_date: 2023-09-17 date_created: 2024-05-21T09:37:09Z date_updated: 2024-05-21T09:37:15Z department: - _id: DEP4000 language: - iso: eng main_file_link: - open_access: '1' url: http://www.apz-rl.de/BioProcessingDays_2023/002_download/BPDs_2023_Tagungsbuch_Titel.pdf oa: '1' publication_status: accepted publisher: DECHEMA e.V. status: public title: 'Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression ' type: conference_poster user_id: '83781' year: '2023' ... --- _id: '13650' author: - first_name: Selina full_name: Uhlendorff, Selina id: '68713' last_name: Uhlendorff orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Uhlendorff S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities.; 2023. apa: Uhlendorff, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. IEEE International Conference on Industrial Informatics, INDIN ’23, Lemgo, Germany. bjps: Uhlendorff S et al. (2023) Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. . chicago: Uhlendorff, Selina, Tanja Hernández Rodriguez, Björn Frahm, and Miriam Pein-Hackelbusch. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023. chicago-de: Uhlendorff, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. 2023. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. din1505-2-1: 'Uhlendorff, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023' havard: S. Uhlendorff, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023. ieee: S. Uhlendorff, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. 2023. mla: Uhlendorff, Selina, et al. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. 2023. short: S. Uhlendorff, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023. ufg: 'Uhlendorff, Selina u. a.: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, o. O. 2023.' van: Uhlendorff S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. 2023. conference: end_date: 2023-07-20 location: Lemgo, Germany name: IEEE International Conference on Industrial Informatics, INDIN ’23 start_date: 2023-07-17 date_created: 2026-03-27T16:43:01Z date_updated: 2026-04-08T13:09:47Z department: - _id: DEP4000 language: - iso: eng status: public title: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities type: conference_speech user_id: '83778' year: '2023' ... --- _id: '10201' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Selina full_name: Ramm, Selina id: '68713' last_name: Ramm orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Markus full_name: Lange-Hegermann, Markus id: '71761' last_name: Lange-Hegermann - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development.; 2023. apa: Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (2023). A systematic, model-based workflow for risk-based decision making in upstream development. BioProcessingDays 2023, Recklinghausen, Germany. bjps: Hernández Rodriguez T et al. (2023) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. . chicago: Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann, and Björn Frahm. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, 2023. chicago-de: Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann und Björn Frahm. 2023. A systematic, model-based workflow for risk-based decision making in upstream development. din1505-2-1: 'Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development, 2023' havard: T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, 2023. ieee: T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, and B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development. 2023. mla: Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. 2023. short: T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, 2023. ufg: 'Hernández Rodriguez, Tanja u. a.: A systematic, model-based workflow for risk-based decision making in upstream development, o. O. 2023.' van: Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development. 2023. conference: end_date: 2023-03-01 location: Recklinghausen, Germany name: BioProcessingDays 2023 start_date: 2023-02-27 date_created: 2023-08-08T14:54:44Z date_updated: 2024-08-02T09:41:01Z department: - _id: DEP4000 language: - iso: eng main_file_link: - open_access: '1' url: http://www.apz-rl.de/BioProcessingDays_2023/002_download/BPDs_2023_Tagungsbuch_Titel.pdf oa: '1' publication_status: published status: public title: A systematic, model-based workflow for risk-based decision making in upstream development type: conference_poster user_id: '83781' year: '2023' ... --- _id: '10788' abstract: - lang: eng text: For process monitoring, an adequate data preprocessing is crucial to link accessible inline process data with offline measured target variables. Literature, however, does not provide systematic preprocessing strategies. The effects of five different preprocessing strategies on data from a Dielectric Spectroscopy system applied to the Viable Cell Density (VCD) of a mammalian cell cultivation were thus evaluated. Single-frequency measurements are typically used to model the VCD over the growth phase using linear regression or the Cole-Cole model and served as a reference. As multi-frequency measurement is promising to model the VCD beyond the growth phase using Partial Least Squares Regression (PLSR), we further aimed to determine, whether replacing linear regression by PLSR shows comparable modeling performance. All five preprocessing strategies led to comparable results. Exemplary, when using capacitance values at a frequency of 3347 kHz, linear regression resulted in a R2 of 0.90 and a standard deviation of 0.4 % on average. Both normalization techniques had the same positive effect on the results of PLSR. The order of smoothing and normalization was irrelevant for both regression methods. Comparing the results of linear regression and PLSR, the latter obtained on average 9 % better results. Therefore, we concluded that PLSR is preferable over linear regression and is potentially suitable to model the VCD beyond the growth phase, which is suggested to be investigated based on more data sets. author: - first_name: Selina full_name: Ramm, Selina id: '68713' last_name: Ramm orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. (Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , eds.). IEEE; 2023:1-6. doi:10.1109/INDIN51400.2023.10218012 apa: Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. In J. Jasperneite, L. Wisniewski, K. Fung Man, & Institute of Electrical and Electronics Engineers (Eds.), 2023 IEEE 21st International Conference on Industrial Informatics (INDIN) (pp. 1–6). IEEE. https://doi.org/10.1109/INDIN51400.2023.10218012 bjps: 'Ramm S et al. (2023) Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, Jasperneite J et al. (eds). [Piscataway, NJ]: IEEE.' chicago: 'Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm, and Miriam Pein-Hackelbusch. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. Edited by Jürgen Jasperneite, Lukasz Wisniewski, Kim Fung Man, and Institute of Electrical and Electronics Engineers . 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE, 2023. https://doi.org/10.1109/INDIN51400.2023.10218012.' chicago-de: 'Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. 2023. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. Hg. von Jürgen Jasperneite, Lukasz Wisniewski, Kim Fung Man, und Institute of Electrical and Electronics Engineers . 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE. doi:10.1109/INDIN51400.2023.10218012, .' din1505-2-1: 'Ramm, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam ; Jasperneite, J. ; Wisniewski, L. ; Fung Man, K. ; Institute of Electrical and Electronics Engineers (Hrsg.): Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. [Piscataway, NJ] : IEEE, 2023' havard: S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023. ieee: 'S. Ramm, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. [Piscataway, NJ]: IEEE, 2023, pp. 1–6. doi: 10.1109/INDIN51400.2023.10218012.' mla: Ramm, Selina, et al. “Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities.” 2023 IEEE 21st International Conference on Industrial Informatics (INDIN), edited by Jürgen Jasperneite et al., IEEE, 2023, pp. 1–6, https://doi.org/10.1109/INDIN51400.2023.10218012. short: S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023. ufg: 'Ramm, Selina u. a.: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, hg. von Jasperneite, Jürgen u. a., [Piscataway, NJ] 2023.' van: 'Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , editors. 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE; 2023.' conference: end_date: 2023-07-20 location: Lemgo name: 21st International Conference on Industrial Informatics (INDIN) start_date: 2023-07-18 corporate_editor: - 'Institute of Electrical and Electronics Engineers ' date_created: 2023-11-21T08:17:12Z date_updated: 2025-04-29T07:38:03Z department: - _id: DEP4022 - _id: DEP4028 doi: 10.1109/INDIN51400.2023.10218012 editor: - first_name: Jürgen full_name: Jasperneite, Jürgen id: '1899' last_name: Jasperneite - first_name: Lukasz full_name: Wisniewski, Lukasz id: '1710' last_name: Wisniewski - first_name: Kim full_name: Fung Man, Kim last_name: Fung Man keyword: - Spectroscopy - Smoothing methods - Systematics - Phase measurement - Linear regression - Data models - Dielectric measurement language: - iso: eng main_file_link: - open_access: '1' url: https://ieeexplore.ieee.org/document/10218012 oa: '1' page: 1-6 place: '[Piscataway, NJ]' publication: 2023 IEEE 21st International Conference on Industrial Informatics (INDIN) publication_identifier: eisbn: - 978-1-6654-9313-0 isbn: - 978-1-6654-9314-7 issn: - 1935-4576 publication_status: published publisher: IEEE status: public title: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities type: conference_editor_article user_id: '83781' year: '2023' ... --- _id: '11377' abstract: - lang: eng text: consuming and often performed rather empirically. Efficient optimization of multiple objectives such as process time, viable cell density, number of operating steps & cultivation scales, required medium, amount of product as well as product quality depicts a promising approach. This contribution presents a workflow which couples uncertainty-based upstream simulation and Bayes optimization using Gaussian processes. Its application is demonstrated in a simulation case study for a relevant industrial task in process development, the design of a robust cell culture expansion process (seed train), meaning that despite uncertainties and variabilities concerning cell growth, low variations of viable cell density during the seed train are obtained. Compared to a non-optimized reference seed train, the optimized process showed much lower deviation rates regarding viable cell densities (<10% instead of 41.7%) using five or four shake flask scales and seed train duration could be reduced by 56 h from 576 h to 520 h. Overall, it is shown that applying Bayes optimization allows for optimization of a multi-objective optimization function with several optimizable input variables and under a considerable amount of constraints with a low computational effort. This approach provides the potential to be used in the form of a decision tool, e.g., for the choice of an optimal and robust seed train design or for further optimization tasks within process development. article_number: '883' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Anton full_name: Sekulic, Anton last_name: Sekulic - first_name: Markus full_name: Lange-Hegermann, Markus id: '71761' last_name: Lange-Hegermann - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes. 2022;10(5). doi:10.3390/pr10050883 apa: Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes, 10(5), Article 883. https://doi.org/10.3390/pr10050883 bjps: Hernández Rodriguez T et al. (2022) Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes 10. chicago: Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann, and Björn Frahm. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Processes 10, no. 5 (2022). https://doi.org/10.3390/pr10050883. chicago-de: Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann und Björn Frahm. 2022. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes 10, Nr. 5. doi:10.3390/pr10050883, . din1505-2-1: 'Hernández Rodriguez, Tanja ; Sekulic, Anton ; Lange-Hegermann, Markus ; Frahm, Björn: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In: Processes Bd. 10. Basel, MDPI AG (2022), Nr. 5' havard: T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, Processes. 10 (2022). ieee: 'T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, and B. Frahm, “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design,” Processes, vol. 10, no. 5, Art. no. 883, 2022, doi: 10.3390/pr10050883.' mla: Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Processes, vol. 10, no. 5, 883, 2022, https://doi.org/10.3390/pr10050883. short: T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Processes 10 (2022). ufg: 'Hernández Rodriguez, Tanja u. a.: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design, in: Processes 10 (2022), H. 5.' van: Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. Processes. 2022;10(5). date_created: 2024-04-25T13:35:04Z date_updated: 2024-05-21T09:30:15Z department: - _id: DEP4000 doi: 10.3390/pr10050883 intvolume: ' 10' issue: '5' keyword: - Gaussian processes - Bayes optimization - Pareto optimization - multi-objective - cell culture - seed train language: - iso: eng place: Basel publication: Processes publication_identifier: eissn: - 2227-9717 publication_status: published publisher: MDPI AG status: public title: Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design type: scientific_journal_article user_id: '83781' volume: 10 year: '2022' ... --- _id: '7932' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Selina full_name: Ramm, Selina id: '68713' last_name: Ramm orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Markus full_name: Lange-Hegermann, Markus id: '71761' last_name: Lange-Hegermann - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. apa: Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (n.d.). A systematic, model-based workflow for risk-based decision making in upstream development. 5th annual Bioprocessing Summit Europe, Barcelona, Spain. bjps: Hernández Rodriguez T et al. (n.d.) A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. . chicago: Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann, and Björn Frahm. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, n.d. chicago-de: Hernández Rodriguez, Tanja, Selina Ramm, Markus Lange-Hegermann und Björn Frahm. A systematic, model-based workflow for risk-based decision making in upstream development. din1505-2-1: 'Hernández Rodriguez, Tanja ; Ramm, Selina ; Lange-Hegermann, Markus ; Frahm, Björn: A systematic, model-based workflow for risk-based decision making in upstream development' havard: T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development, n.d. ieee: T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, and B. Frahm, A systematic, model-based workflow for risk-based decision making in upstream development. mla: Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. short: T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, n.d. ufg: 'Hernández Rodriguez, Tanja u. a.: A systematic, model-based workflow for risk-based decision making in upstream development, o. O. u. J. .' van: Hernández Rodriguez T, Ramm S, Lange-Hegermann M, Frahm B. A systematic, model-based workflow for risk-based decision making in upstream development. conference: end_date: 2022-03-24 location: Barcelona, Spain name: 5th annual Bioprocessing Summit Europe start_date: 2022-03-22 date_created: 2022-05-04T19:35:20Z date_updated: 2024-08-02T13:57:53Z department: - _id: DEP4021 language: - iso: eng publication_status: accepted status: public title: A systematic, model-based workflow for risk-based decision making in upstream development type: conference_poster user_id: '83781' year: '2022' ... --- _id: '7976' author: - first_name: Veronika full_name: Gassenmeier, Veronika id: '74048' last_name: Gassenmeier - first_name: Sahar full_name: Deppe, Sahar id: '52121' last_name: Deppe - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Fabian full_name: Kuhfuß, Fabian last_name: Kuhfuß - first_name: André full_name: Moser, André last_name: Moser - first_name: Volker C. full_name: Hass, Volker C. last_name: Hass - first_name: Kim B. full_name: Kuchemüller, Kim B. last_name: Kuchemüller - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Johannes full_name: Möller, Johannes last_name: Möller - first_name: George Adrian full_name: Ifrim, George Adrian id: '73814' last_name: Ifrim - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Gassenmeier V, Deppe S, Hernández Rodriguez T, et al. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology. 2022;4:102-119. doi:10.1016/j.crbiot.2022.01.005 apa: Gassenmeier, V., Deppe, S., Hernández Rodriguez, T., Kuhfuß, F., Moser, A., Hass, V. C., Kuchemüller, K. B., Pörtner, R., Möller, J., Ifrim, G. A., & Frahm, B. (2022). Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology, 4, 102–119. https://doi.org/10.1016/j.crbiot.2022.01.005 bjps: Gassenmeier V et al. (2022) Model-Assisted DoE Applied to Microalgae Processes, Current Research in Biotechnology. Current Research in Biotechnology 4, 102–119. chicago: 'Gassenmeier, Veronika, Sahar Deppe, Tanja Hernández Rodriguez, Fabian Kuhfuß, André Moser, Volker C. Hass, Kim B. Kuchemüller, et al. “Model-Assisted DoE Applied to Microalgae Processes, Current Research in Biotechnology.” Current Research in Biotechnology 4 (2022): 102–19. https://doi.org/10.1016/j.crbiot.2022.01.005.' chicago-de: 'Gassenmeier, Veronika, Sahar Deppe, Tanja Hernández Rodriguez, Fabian Kuhfuß, André Moser, Volker C. Hass, Kim B. Kuchemüller, u. a. 2022. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology 4: 102–119. doi:10.1016/j.crbiot.2022.01.005, .' din1505-2-1: 'Gassenmeier, Veronika ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Kuhfuß, Fabian ; Moser, André ; Hass, Volker C. ; Kuchemüller, Kim B. ; Pörtner, Ralf ; u. a.: Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. In: Current Research in Biotechnology Bd. 4, Elsevier (2022), S. 102–119' havard: V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology, Current Research in Biotechnology. 4 (2022) 102–119. ieee: 'V. Gassenmeier et al., “Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology,” Current Research in Biotechnology, vol. 4, pp. 102–119, 2022, doi: 10.1016/j.crbiot.2022.01.005.' mla: Gassenmeier, Veronika, et al. “Model-Assisted DoE Applied to Microalgae Processes, Current Research in Biotechnology.” Current Research in Biotechnology, vol. 4, 2022, pp. 102–19, https://doi.org/10.1016/j.crbiot.2022.01.005. short: V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Current Research in Biotechnology 4 (2022) 102–119. ufg: 'Gassenmeier, Veronika u. a.: Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology, in: Current Research in Biotechnology 4 (2022), S. 102–119.' van: Gassenmeier V, Deppe S, Hernández Rodriguez T, Kuhfuß F, Moser A, Hass VC, et al. Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology. 2022;4:102–19. date_created: 2022-05-05T11:14:10Z date_updated: 2024-08-05T07:10:50Z department: - _id: DEP4021 doi: 10.1016/j.crbiot.2022.01.005 intvolume: ' 4' language: - iso: eng page: 102-119 publication: Current Research in Biotechnology publication_identifier: eissn: - '2590-2628 ' publication_status: published publisher: Elsevier quality_controlled: '1' status: public title: Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology type: scientific_journal_article user_id: '83781' volume: 4 year: '2022' ... --- _id: '7977' abstract: - lang: eng text: Kinetic growth models are a useful tool for a better understanding of microalgal cultivation and for optimizing cultivation conditions. The evaluation of such models requires experimental data that is laborious to generate in bioreactor settings. The experimental shake flask setting used in this study allows to run 12 experiments at the same time, with 6 individual light intensities and light durations. This way, 54 biomass data sets were generated for the cultivation of the microalgae Chlorella vulgaris. To identify the model parameters, a stepwise parameter estimation procedure was applied. First, light-associated model parameters were estimated using additional measurements of local light intensities at differ heights within medium at different biomass concentrations. Next, substrate related model parameters were estimated, using experiments for which biomass and nitrate data were provided. Afterwards, growth-related model parameters were estimated by application of an extensive cross validation procedure. author: - first_name: Fabian full_name: Kuhfuß, Fabian last_name: Kuhfuß - first_name: Veronika full_name: Gassenmeier, Veronika id: '74048' last_name: Gassenmeier - first_name: Sahar full_name: Deppe, Sahar id: '52121' last_name: Deppe - first_name: George Adrian full_name: Ifrim, George Adrian id: '73814' last_name: Ifrim - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Kuhfuß F, Gassenmeier V, Deppe S, Ifrim GA, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering. 2022;45:15-30. doi:10.1007/s00449-021-02627-2 apa: Kuhfuß, F., Gassenmeier, V., Deppe, S., Ifrim, G. A., Hernández Rodriguez, T., & Frahm, B. (2022). View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering, 45, 15–30. https://doi.org/10.1007/s00449-021-02627-2 bjps: Kuhfuß F et al. (2022) View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks. Bioprocess and Biosystems Engineering 45, 15–30. chicago: 'Kuhfuß, Fabian, Veronika Gassenmeier, Sahar Deppe, George Adrian Ifrim, Tanja Hernández Rodriguez, and Björn Frahm. “View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks.” Bioprocess and Biosystems Engineering 45 (2022): 15–30. https://doi.org/10.1007/s00449-021-02627-2.' chicago-de: 'Kuhfuß, Fabian, Veronika Gassenmeier, Sahar Deppe, George Adrian Ifrim, Tanja Hernández Rodriguez und Björn Frahm. 2022. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering 45: 15–30. doi:10.1007/s00449-021-02627-2, .' din1505-2-1: 'Kuhfuß, Fabian ; Gassenmeier, Veronika ; Deppe, Sahar ; Ifrim, George Adrian ; Hernández Rodriguez, Tanja ; Frahm, Björn: View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. In: Bioprocess and Biosystems Engineering Bd. 45. Berlin, Springer (2022), S. 15–30' havard: F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a mechanistic model of Chlorella vulgaris in incubated shake flasks, Bioprocess and Biosystems Engineering. 45 (2022) 15–30. ieee: 'F. Kuhfuß, V. Gassenmeier, S. Deppe, G. A. Ifrim, T. Hernández Rodriguez, and B. Frahm, “View on a mechanistic model of Chlorella vulgaris in incubated shake flasks,” Bioprocess and Biosystems Engineering, vol. 45, pp. 15–30, 2022, doi: 10.1007/s00449-021-02627-2.' mla: Kuhfuß, Fabian, et al. “View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks.” Bioprocess and Biosystems Engineering, vol. 45, 2022, pp. 15–30, https://doi.org/10.1007/s00449-021-02627-2. short: F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, Bioprocess and Biosystems Engineering 45 (2022) 15–30. ufg: 'Kuhfuß, Fabian u. a.: View on a mechanistic model of Chlorella vulgaris in incubated shake flasks, in: Bioprocess and Biosystems Engineering 45 (2022), S. 15–30.' van: Kuhfuß F, Gassenmeier V, Deppe S, Ifrim GA, Hernández Rodriguez T, Frahm B. View on a mechanistic model of Chlorella vulgaris in incubated shake flasks. Bioprocess and Biosystems Engineering. 2022;45:15–30. date_created: 2022-05-05T11:28:56Z date_updated: 2024-08-05T07:07:37Z department: - _id: DEP4021 doi: 10.1007/s00449-021-02627-2 intvolume: ' 45' language: - iso: eng page: 15-30 place: Berlin publication: Bioprocess and Biosystems Engineering publication_identifier: eissn: - 1615-7605 issn: - '1615-7591 ' publication_status: published publisher: Springer quality_controlled: '1' status: public title: View on a mechanistic model of Chlorella vulgaris in incubated shake flasks type: scientific_journal_article user_id: '83781' volume: 45 year: '2022' ... --- _id: '10193' abstract: - lang: eng text: Development and optimization of biopharmaceutical production processes with cell cultures is cost- and time-consuming and often performed rather empirically. Efficient optimization of multiple objectives such as process time, viable cell density, number of operating steps & cultivation scales, required medium, amount of product as well as product quality depicts a promising approach. This contribution presents a workflow which couples uncertainty-based upstream simulation and Bayes optimization using Gaussian processes. Its application is demonstrated in a simulation case study for a relevant industrial task in process development, the design of a robust cell culture expansion process (seed train), meaning that despite uncertainties and variabilities concerning cell growth, low variations of viable cell density during the seed train are obtained. Compared to a non-optimized reference seed train, the optimized process showed much lower deviation rates regarding viable cell densities (<10% instead of 41.7%) using five or four shake flask scales and seed train duration could be reduced by 56 h from 576 h to 520 h. Overall, it is shown that applying Bayes optimization allows for optimization of a multi-objective optimization function with several optimizable input variables and under a considerable amount of constraints with a low computational effort. This approach provides the potential to be used in the form of a decision tool, e.g., for the choice of an optimal and robust seed train design or for further optimization tasks within process development. author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Anton full_name: Sekulic, Anton last_name: Sekulic - first_name: Markus full_name: Lange-Hegermann, Markus id: '71761' last_name: Lange-Hegermann - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: 'Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner R, Möller J, eds. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Vol special issue. Processes : open access journal. MDPI; 2022:21-48. doi:https://doi.org/10.3390/pr10050883' apa: 'Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In R. Pörtner & J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue (pp. 21–48). MDPI. https://doi.org/10.3390/pr10050883' bjps: 'Hernández Rodriguez T et al. (2022) Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design. In Pörtner R and Möller J (eds), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue. Basel: MDPI, pp. 21–48.' chicago: 'Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann, and Björn Frahm. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” In Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, edited by Ralf Pörtner and Johannes Möller, special issue:21–48. Processes : Open Access Journal. Basel: MDPI, 2022. https://doi.org/10.3390/pr10050883.' chicago-de: 'Hernández Rodriguez, Tanja, Anton Sekulic, Markus Lange-Hegermann und Björn Frahm. 2022. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, hg. von Ralf Pörtner und Johannes Möller, special issue:21–48. Processes : open access journal. Basel: MDPI. doi:https://doi.org/10.3390/pr10050883, .' din1505-2-1: 'Hernández Rodriguez, Tanja ; Sekulic, Anton ; Lange-Hegermann, Markus ; Frahm, Björn: Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner, R. ; Möller, J. (Hrsg.): Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Processes : open access journal. Bd. special issue. Basel : MDPI, 2022, S. 21–48' havard: 'T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022: pp. 21–48.' ieee: 'T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, and B. Frahm, “Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design,” in Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue, R. Pörtner and J. Möller, Eds. Basel: MDPI, 2022, pp. 21–48. doi: https://doi.org/10.3390/pr10050883.' mla: Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, edited by Ralf Pörtner and Johannes Möller, vol. special issue, MDPI, 2022, pp. 21–48, https://doi.org/10.3390/pr10050883. short: 'T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022, pp. 21–48.' ufg: 'Hernández Rodriguez, Tanja u. a.: Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design, in: Pörtner, Ralf/Möller, Johannes (Hgg.): Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Band special issue, Basel 2022 (Processes : open access journal), S. 21–48.' van: 'Hernández Rodriguez T, Sekulic A, Lange-Hegermann M, Frahm B. Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. In: Pörtner R, Möller J, editors. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2022. p. 21–48. (Processes : open access journal; vol. special issue).' date_created: 2023-08-08T12:58:36Z date_updated: 2023-08-16T09:24:16Z department: - _id: DEP4000 doi: https://doi.org/10.3390/pr10050883 editor: - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Johannes full_name: Möller, Johannes last_name: Möller keyword: - Gaussian processes - Bayes optimization - Pareto optimization - multi-objective - cell culture - seed train language: - iso: eng page: 21-48 place: Basel publication: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing publication_identifier: eisbn: - 978-3-0365-5209-5 eissn: - 2227-9717 isbn: - 978-3-0365-5210-1 publication_status: published publisher: MDPI quality_controlled: '1' series_title: 'Processes : open access journal' status: public title: Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design type: book_chapter user_id: '83781' volume: special issue year: '2022' ... --- _id: '10197' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Christoph full_name: Posch, Christoph last_name: Posch - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture.; 2022. apa: Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2022). Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture. In ACHEMA 2022. ACHEMA 2022, Frankfurt am Main, Germany. bjps: Hernández Rodriguez T et al. (2022) Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. . chicago: Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, and Björn Frahm. Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. ACHEMA 2022, 2022. chicago-de: Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner und Björn Frahm. 2022. Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture. ACHEMA 2022. din1505-2-1: 'Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture, 2022' havard: T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture, 2022. ieee: T. Hernández Rodriguez, C. Posch, R. Pörtner, and B. Frahm, Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture. 2022. mla: Hernández Rodriguez, Tanja, et al. “Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture.” ACHEMA 2022, 2022. short: T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, 2022. ufg: 'Hernández Rodriguez, Tanja u. a.: Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture, o. O. 2022.' van: Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture. ACHEMA 2022. 2022. conference: end_date: 2022-08-26 location: Frankfurt am Main, Germany name: ACHEMA 2022 start_date: 2022-08-22 date_created: 2023-08-08T13:26:41Z date_updated: 2023-08-14T09:40:43Z department: - _id: DEP4000 language: - iso: eng publication: ACHEMA 2022 publication_status: published status: public title: Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture type: conference_speech user_id: '83781' year: '2022' ... --- _id: '10198' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Markus full_name: Lange-Hegermann, Markus id: '71761' last_name: Lange-Hegermann - first_name: Florian M. full_name: Wurm, Florian M. last_name: Wurm - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion. apa: 'Hernández Rodriguez, T., Pörtner, R., Lange-Hegermann, M., Wurm, F. M., & Frahm, B. (n.d.). A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion. 27th Meeting of the European Society for Animal Cell Technology (ESACT): Advanced Cell Technologies: Making Protein, Cell, and Gene Therapies a Reality, Lisbon, Portugal .' bjps: Hernández Rodriguez T et al. (n.d.) A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion. . chicago: Hernández Rodriguez, Tanja, Ralf Pörtner, Markus Lange-Hegermann, Florian M. Wurm, and Björn Frahm. A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion, n.d. chicago-de: Hernández Rodriguez, Tanja, Ralf Pörtner, Markus Lange-Hegermann, Florian M. Wurm und Björn Frahm. A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion. din1505-2-1: 'Hernández Rodriguez, Tanja ; Pörtner, Ralf ; Lange-Hegermann, Markus ; Wurm, Florian M. ; Frahm, Björn: A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion' havard: T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion, n.d. ieee: T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F. M. Wurm, and B. Frahm, A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion. mla: Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion. short: T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion, n.d. ufg: 'Hernández Rodriguez, Tanja u. a.: A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion, o. O. u. J. .' van: Hernández Rodriguez T, Pörtner R, Lange-Hegermann M, Wurm FM, Frahm B. A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion. conference: end_date: 2022-06-29 location: 'Lisbon, Portugal ' name: '27th Meeting of the European Society for Animal Cell Technology (ESACT): Advanced Cell Technologies: Making Protein, Cell, and Gene Therapies a Reality' start_date: 2022-06-26 date_created: 2023-08-08T13:50:25Z date_updated: 2024-08-02T14:14:55Z department: - _id: DEP4000 language: - iso: eng publication_status: accepted quality_controlled: '1' status: public title: A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion type: conference_poster user_id: '83781' year: '2022' ... --- _id: '11376' abstract: - lang: eng text: concentration is an important objective. The phenotype of the cells in a reactor plays an important role. Are clonal cell populations showing high cell-specific growth rates more favorable than cell lines with higher cell-specific productivities or vice versa? Five clonal Chinese hamster ovary cell populations were analyzed based on the data of a 3-month-stability study. We adapted a mechanistic cell culture model to the experimental data of one such clonally derived cell population. Uncertainties and prior knowledge concerning model parameters were considered using Bayesian parameter estimations. This model was used then to define an inoculum train protocol. Based on this, we subsequently simulated the impacts of differences in growth rates (±10%) and production rates (±10% and ±50%) on the overall cultivation time, including making the inoculum train cultures; the final production phase, the volumetric titer in that bioreactor and the ratio of both, defined as overall process productivity. We showed thus unequivocally that growth rates have a higher impact (up to three times) on overall process productivity and for product output per year, whereas cells with higher productivity can potentially generate higher product concentrations in the production vessel. article_number: '964' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Sophie full_name: Morerod, Sophie last_name: Morerod - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Florian M. full_name: Wurm, Florian M. last_name: Wurm - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes. 2021;9(6). doi:10.3390/pr9060964 apa: Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm, B. (2021). Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes, 9(6), Article 964. https://doi.org/10.3390/pr9060964 bjps: Hernández Rodriguez T et al. (2021) Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes 9. chicago: Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm, and Björn Frahm. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study.” Processes 9, no. 6 (2021). https://doi.org/10.3390/pr9060964. chicago-de: Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm und Björn Frahm. 2021. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes 9, Nr. 6. doi:10.3390/pr9060964, . din1505-2-1: 'Hernández Rodriguez, Tanja ; Morerod, Sophie ; Pörtner, Ralf ; Wurm, Florian M. ; Frahm, Björn: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. In: Processes Bd. 9. Basel, MDPI AG (2021), Nr. 6' havard: T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study, Processes. 9 (2021). ieee: 'T. Hernández Rodriguez, S. Morerod, R. Pörtner, F. M. Wurm, and B. Frahm, “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study,” Processes, vol. 9, no. 6, Art. no. 964, 2021, doi: 10.3390/pr9060964.' mla: Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study.” Processes, vol. 9, no. 6, 964, 2021, https://doi.org/10.3390/pr9060964. short: T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Processes 9 (2021). ufg: 'Hernández Rodriguez, Tanja u. a.: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study, in: Processes 9 (2021), H. 6.' van: Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study. Processes. 2021;9(6). date_created: 2024-04-25T13:34:26Z date_updated: 2024-05-21T09:29:02Z department: - _id: DEP4000 doi: 10.3390/pr9060964 intvolume: ' 9' issue: '6' keyword: - clonal cell population - phenotypic diversity - inoculum train - uncertainty-based - cell culture model - biopharmaceutical manufacturing language: - iso: eng place: Basel publication: Processes publication_identifier: eissn: - 2227-9717 publication_status: published publisher: MDPI AG status: public title: Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study type: scientific_journal_article user_id: '83781' volume: 9 year: '2021' ... --- _id: '7927' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Frahm B. Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction.; 2021. apa: Hernández Rodriguez, T., & Frahm, B. (2021). Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. International Week “Digitalization and Sustainability in Higher Education,” SeAMK, Seinäjoki, Finnland. bjps: Hernández Rodriguez T and Frahm B (2021) Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction. . chicago: Hernández Rodriguez, Tanja, and Björn Frahm. Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction, 2021. chicago-de: Hernández Rodriguez, Tanja und Björn Frahm. 2021. Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. din1505-2-1: 'Hernández Rodriguez, Tanja ; Frahm, Björn: Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction, 2021' havard: T. Hernández Rodriguez, B. Frahm, Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction, 2021. ieee: T. Hernández Rodriguez and B. Frahm, Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. 2021. mla: Hernández Rodriguez, Tanja, and Björn Frahm. Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction. 2021. short: T. Hernández Rodriguez, B. Frahm, Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction, 2021. ufg: 'Hernández Rodriguez, Tanja/Frahm, Björn: Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction, o. O. 2021.' van: Hernández Rodriguez T, Frahm B. Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. 2021. conference: end_date: 2021-02-19 location: SeAMK, Seinäjoki, Finnland name: International Week 'Digitalization and Sustainability in Higher Education' start_date: 2021-02-15 date_created: 2022-05-04T19:17:03Z date_updated: 2023-08-21T08:11:25Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction type: conference_speech user_id: '83781' year: '2021' ... --- _id: '7931' author: - first_name: André full_name: Moser, André last_name: Moser - first_name: Johannes full_name: Möller, Johannes last_name: Möller - first_name: Kim B. full_name: Kuchemüller, Kim B. last_name: Kuchemüller - first_name: Sahar full_name: Deppe, Sahar last_name: Deppe - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Veronika full_name: Gassenmeier, Veronika id: '74048' last_name: Gassenmeier - first_name: George Adrian full_name: Ifrim, George Adrian id: '73814' last_name: Ifrim - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Volker C. full_name: Hass, Volker C. last_name: Hass citation: ama: Moser A, Möller J, Kuchemüller KB, et al. Model-Assisted Design of Experiments - Concept, Software and Applications.; 2021. apa: Moser, A., Möller, J., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., … Hass, V. C. (2021). Model-assisted Design of Experiments - Concept, Software and Applications. Presented at the 24th International Congress of Chemical and Process Engineering, CHISA 2021, as a web conference, Prague, Czech Republic. bjps: Moser A et al. (2021) Model-Assisted Design of Experiments - Concept, Software and Applications. . chicago: Moser, André, Johannes Möller, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Veronika Gassenmeier, George Adrian Ifrim, Björn Frahm, Ralf Pörtner, and Volker C. Hass. Model-Assisted Design of Experiments - Concept, Software and Applications, 2021. chicago-de: Moser, André, Johannes Möller, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Veronika Gassenmeier, George Adrian Ifrim, Björn Frahm, Ralf Pörtner und Volker C. Hass. 2021. Model-assisted Design of Experiments - Concept, Software and Applications. din1505-2-1: 'Moser, André ; Möller, Johannes ; Kuchemüller, Kim B. ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Ifrim, George Adrian ; Frahm, Björn ; u. a.: Model-assisted Design of Experiments - Concept, Software and Applications, 2021' havard: A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-assisted Design of Experiments - Concept, Software and Applications, 2021. ieee: A. Moser et al., Model-assisted Design of Experiments - Concept, Software and Applications. 2021. mla: Moser, André, et al. Model-Assisted Design of Experiments - Concept, Software and Applications. 2021. short: A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-Assisted Design of Experiments - Concept, Software and Applications, 2021. ufg: 'Moser, André et. al. (2021): Model-assisted Design of Experiments - Concept, Software and Applications.' van: Moser A, Möller J, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Gassenmeier V, et al. Model-assisted Design of Experiments - Concept, Software and Applications. 2021. conference: end_date: 2021-03-18 location: as a web conference, Prague, Czech Republic name: 24th International Congress of Chemical and Process Engineering, CHISA 2021 start_date: 2021-03-15 date_created: 2022-05-04T19:32:05Z date_updated: 2023-03-15T13:50:12Z department: - _id: DEP4021 language: - iso: eng status: public title: Model-assisted Design of Experiments - Concept, Software and Applications type: conference_poster user_id: '45673' year: 2021 ... --- _id: '7983' abstract: - lang: eng text: For the manufacturing of complex biopharmaceuticals using bioreactors with cultivated mammalian cells, high product concentration is an important objective. The phenotype of the cells in a reactor plays an important role. Are clonal cell populations showing high cell-specific growth rates more favorable than cell lines with higher cell-specific productivities or vice versa? Five clonal Chinese hamster ovary cell populations were analyzed based on the data of a 3-month-stability study. We adapted a mechanistic cell culture model to the experimental data of one such clonally derived cell population. Uncertainties and prior knowledge concerning model parameters were considered using Bayesian parameter estimations. This model was used then to define an inoculum train protocol. Based on this, we subsequently simulated the impacts of differences in growth rates (±10%) and production rates (±10% and ±50%) on the overall cultivation time, including making the inoculum train cultures; the final production phase, the volumetric titer in that bioreactor and the ratio of both, defined as overall process productivity. We showed thus unequivocally that growth rates have a higher impact (up to three times) on overall process productivity and for product output per year, whereas cells with higher productivity can potentially generate higher product concentrations in the production vessel. author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Sophie full_name: Morerod, Sophie last_name: Morerod - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Florian M. full_name: Wurm, Florian M. last_name: Wurm - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: 'Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Vol special issue. Processes : open access journal . MDPI; 2021:49-74. doi:10.3390/pr9060964' apa: 'Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm, B. (2021). Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing: Vol. special issue (pp. 49–74). MDPI. https://doi.org/10.3390/pr9060964' bjps: 'Hernández Rodriguez T et al. (2021) Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study. Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue. Basel: MDPI, pp. 49–74.' chicago: 'Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm, and Björn Frahm. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study.” In Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, special issue:49–74. Processes : Open Access Journal . Basel: MDPI, 2021. https://doi.org/10.3390/pr9060964.' chicago-de: 'Hernández Rodriguez, Tanja, Sophie Morerod, Ralf Pörtner, Florian M. Wurm und Björn Frahm. 2021. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, special issue:49–74. Processes : open access journal . Basel: MDPI. doi:10.3390/pr9060964, .' din1505-2-1: 'Hernández Rodriguez, Tanja ; Morerod, Sophie ; Pörtner, Ralf ; Wurm, Florian M. ; Frahm, Björn: Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Processes : open access journal . Bd. special issue. Basel : MDPI, 2021, S. 49–74' havard: 'T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021: pp. 49–74.' ieee: 'T. Hernández Rodriguez, S. Morerod, R. Pörtner, F. M. Wurm, and B. Frahm, “Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study,” in Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue, Basel: MDPI, 2021, pp. 49–74. doi: 10.3390/pr9060964.' mla: Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study.” Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue, MDPI, 2021, pp. 49–74, https://doi.org/10.3390/pr9060964. short: 'T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021, pp. 49–74.' ufg: 'Hernández Rodriguez, Tanja u. a.: Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study, in: o. Hg.: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, Band special issue, Basel 2021 (Processes : open access journal ), S. 49–74.' van: 'Hernández Rodriguez T, Morerod S, Pörtner R, Wurm FM, Frahm B. Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. In: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing. Basel: MDPI; 2021. p. 49–74. (Processes : open access journal ; vol. special issue).' date_created: 2022-05-05T12:55:52Z date_updated: 2023-08-16T09:17:50Z department: - _id: DEP4021 doi: 10.3390/pr9060964 keyword: - clonal cell population - phenotypic diversity - inoculum train - uncertainty-based - cell culture model - biopharmaceutical manufacturing language: - iso: eng page: 49-74 place: Basel publication: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing publication_identifier: eisbn: - 978-3-0365-5209-5 isbn: - 978-3-0365-5210-1 issn: - '2227-9717 ' publication_status: published publisher: MDPI quality_controlled: '1' series_title: 'Processes : open access journal ' status: public title: Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study type: book_chapter user_id: '83781' volume: special issue year: '2021' ... --- _id: '7985' abstract: - lang: eng text: Bioprocess modeling has become a useful tool for prediction of the process future with the aim to deduce operating decisions (e.g. transfer or feeds). Due to variabilities, which often occur between and within batches, updating (re-estimation) of model parameters is required at certain time intervals (dynamic parameter estimation) to obtain reliable predictions. This can be challenging in the presence of low sampling frequencies (e.g. every 24 h), different consecutive scales and large measurement errors, as in the case of cell culture seed trains. This contribution presents an iterative learning workflow which generates and incorporates knowledge concerning cell growth during the process by using a moving horizon estimation (MHE) approach for updating of model parameters. This estimation technique is compared to a classical weighted least squares estimation (WLSE) approach in the context of model updating over three consecutive cultivation scales (40–2160 L) of an industrial cell culture seed train. Both techniques were investigated regarding robustness concerning the aforementioned challenges and the required amount of experimental data (estimation horizon). It is shown how the proposed MHE can deal with the aforementioned difficulties by the integration of prior knowledge, even if only data at two sampling points are available, outperforming the classical WLSE approach. This workflow allows to adequately integrate current process behavior into the model and can therefore be a suitable component of a digital twin. author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Christoph full_name: Posch, Christoph last_name: Posch - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering. 2021;44(4):793-808. doi:10.1007/s00449-020-02488-1 apa: Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2021). Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering, 44(4), 793–808. https://doi.org/10.1007/s00449-020-02488-1 bjps: Hernández Rodriguez T et al. (2021) Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train. Bioprocess and Biosystems Engineering 44, 793–808. chicago: 'Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, and Björn Frahm. “Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train.” Bioprocess and Biosystems Engineering 44, no. 4 (2021): 793–808. https://doi.org/10.1007/s00449-020-02488-1 .' chicago-de: 'Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner und Björn Frahm. 2021. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering 44, Nr. 4: 793–808. doi:10.1007/s00449-020-02488-1 , .' din1505-2-1: 'Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. In: Bioprocess and Biosystems Engineering Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 793–808' havard: T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, Bioprocess and Biosystems Engineering. 44 (2021) 793–808. ieee: 'T. Hernández Rodriguez, C. Posch, R. Pörtner, and B. Frahm, “Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train,” Bioprocess and Biosystems Engineering, vol. 44, no. 4, pp. 793–808, 2021, doi: 10.1007/s00449-020-02488-1 .' mla: Hernández Rodriguez, Tanja, et al. “Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train.” Bioprocess and Biosystems Engineering, vol. 44, no. 4, 2021, pp. 793–808, https://doi.org/10.1007/s00449-020-02488-1 . short: T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Bioprocess and Biosystems Engineering 44 (2021) 793–808. ufg: 'Hernández Rodriguez, Tanja u. a.: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train, in: Bioprocess and Biosystems Engineering 44 (2021), H. 4, S. 793–808.' van: Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering. 2021;44(4):793–808. date_created: 2022-05-05T13:06:12Z date_updated: 2023-08-21T07:51:38Z department: - _id: DEP4021 doi: '10.1007/s00449-020-02488-1 ' intvolume: ' 44' issue: '4' keyword: - Dynamic parameter estimation - Bioprocess - Cell cultures - Moving horizon estimation - Prior knowledge language: - iso: eng page: 793-808 place: Berlin ; Heidelberg [u.a.] publication: Bioprocess and Biosystems Engineering publication_identifier: eissn: - 1615-7605 issn: - 1615-7591 publication_status: published publisher: Springer quality_controlled: '1' status: public title: Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train type: scientific_journal_article user_id: '83781' volume: 44 year: '2021' ... --- _id: '7986' abstract: - lang: eng text: Bioprocess development and optimization are still cost- and time-intensive due to the enormous number of experiments involved. In this study, the recently introduced model-assisted Design of Experiments (mDoE) concept (Möller et al. in Bioproc Biosyst Eng 42(5):867, https://doi.org/10.1007/s00449-019-02089-7, 2019) was extended and implemented into a software (“mDoE-toolbox”) to significantly reduce the number of required cultivations. The application of the toolbox is exemplary shown in two case studies with Saccharomyces cerevisiae. In the first case study, a fed-batch process was optimized with respect to the pH value and linearly rising feeding rates of glucose and nitrogen source. Using the mDoE-toolbox, the biomass concentration was increased by 30% compared to previously performed experiments. The second case study was the whole-cell biocatalysis of ethyl acetoacetate (EAA) to (S)-ethyl-3-hydroxybutyrate (E3HB), for which the feeding rates of glucose, nitrogen source, and EAA were optimized. An increase of 80% compared to a previously performed experiment with similar initial conditions was achieved for the E3HB concentration. author: - first_name: André full_name: Moser, André last_name: Moser - first_name: Kim B. full_name: Kuchemüller, Kim B. last_name: Kuchemüller - first_name: Sahar full_name: Deppe, Sahar last_name: Deppe - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Volker C. full_name: Hass, Volker C. last_name: Hass - first_name: Johannes full_name: Möller, Johannes last_name: Möller citation: ama: 'Moser A, Kuchemüller KB, Deppe S, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering. 2021;44(4):683-700. doi:10.1007/s00449-020-02478-3' apa: 'Moser, A., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Frahm, B., Pörtner, R., Hass, V. C., & Möller, J. (2021). Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering, 44(4), 683–700. https://doi.org/10.1007/s00449-020-02478-3' bjps: 'Moser A et al. (2021) Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses. Bioprocess and Biosystems Engineering 44, 683–700.' chicago: 'Moser, André, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Björn Frahm, Ralf Pörtner, Volker C. Hass, and Johannes Möller. “Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses.” Bioprocess and Biosystems Engineering 44, no. 4 (2021): 683–700. https://doi.org/10.1007/s00449-020-02478-3.' chicago-de: 'Moser, André, Kim B. Kuchemüller, Sahar Deppe, Tanja Hernández Rodriguez, Björn Frahm, Ralf Pörtner, Volker C. Hass und Johannes Möller. 2021. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering 44, Nr. 4: 683–700. doi:10.1007/s00449-020-02478-3, .' din1505-2-1: 'Moser, André ; Kuchemüller, Kim B. ; Deppe, Sahar ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pörtner, Ralf ; Hass, Volker C. ; Möller, Johannes: Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. In: Bioprocess and Biosystems Engineering Bd. 44. Berlin ; Heidelberg [u.a.], Springer (2021), Nr. 4, S. 683–700' havard: 'A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, Bioprocess and Biosystems Engineering. 44 (2021) 683–700.' ieee: 'A. Moser et al., “Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses,” Bioprocess and Biosystems Engineering, vol. 44, no. 4, pp. 683–700, 2021, doi: 10.1007/s00449-020-02478-3.' mla: 'Moser, André, et al. “Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses.” Bioprocess and Biosystems Engineering, vol. 44, no. 4, 2021, pp. 683–700, https://doi.org/10.1007/s00449-020-02478-3.' short: A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Bioprocess and Biosystems Engineering 44 (2021) 683–700. ufg: 'Moser, André u. a.: Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses, in: Bioprocess and Biosystems Engineering 44 (2021), H. 4, S. 683–700.' van: 'Moser A, Kuchemüller KB, Deppe S, Hernández Rodriguez T, Frahm B, Pörtner R, et al. Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering. 2021;44(4):683–700.' date_created: 2022-05-05T13:10:11Z date_updated: 2023-08-21T07:55:05Z department: - _id: DEP4021 doi: 10.1007/s00449-020-02478-3 intvolume: ' 44' issue: '4' keyword: - Biocatalysis - Monte Carlo methods - Fed-batch strategy - Model-assisted design of experiments - Quality by design language: - iso: eng page: 683-700 place: Berlin ; Heidelberg [u.a.] publication: Bioprocess and Biosystems Engineering publication_identifier: eissn: - 1615-7605 isbn: - 1615-7591 publication_status: published publisher: Springer quality_controlled: '1' status: public title: 'Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses' type: scientific_journal_article user_id: '83781' volume: 44 year: '2021' ... --- _id: '3349' abstract: - lang: eng text: "Model-based concepts and simulation techniques in combination with digital tools emerge as a key to explore the full potential of biopharmaceutical production processes, which contain several challenging development and process steps. One of these steps is the time- and cost-intensive cell proliferation process (also called seed train) to increase cell number from cell thawing up to production scale. Challenges like complex cell metabolism, batch-to-batch variation, variabilities in cell behavior, and influences of changes in cultivation conditions necessitate adequate digital solutions to provide information about the current and near future process state to derive correct process decisions.\r\nFor this purpose digital seed train twins have proved to be efficient, which digitally display the time-dependent behavior of important process variables based on mathematical models, strategies, and adaption procedures.\r\nThis chapter will outline the needs for digitalization of seed trains, the construction of a digital seed train twin, the role of parameter estimation, and different statistical methods within this context, which are applicable to several problems in the field of bioprocessing. The results of a case study are presented to illustrate a Bayesian approach for parameter estimation and prediction of an industrial cell culture seed train for seed train digitalization." author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: 'Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, eds. Digital Twins Tools and Concepts for Smart Biomanufacturing. Vol 176. Advances in Biochemical Engineering/Biotechnology. Springer; 2021:97-131. doi:https://doi.org/10.1007/10_2020_137' apa: Hernández Rodriguez, T., & Frahm, B. (2021). Digital Seed Train Twins and Statistical Methods. In C. Herwig, R. Pörtner, & J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing (Vol. 176, pp. 97–131). Springer. https://doi.org/10.1007/10_2020_137 bjps: 'Hernández Rodriguez T and Frahm B (2021) Digital Seed Train Twins and Statistical Methods. In Herwig C, Pörtner R and Möller J (eds), Digital Twins Tools and Concepts for Smart Biomanufacturing, vol. 176. Berlin, Heidelberg: Springer, pp. 97–131.' chicago: 'Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins and Statistical Methods.” In Digital Twins Tools and Concepts for Smart Biomanufacturing, edited by Christoph Herwig, Ralf Pörtner, and Johannes Möller, 176:97–131. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer, 2021. https://doi.org/10.1007/10_2020_137.' chicago-de: 'Hernández Rodriguez, Tanja und Björn Frahm. 2021. Digital Seed Train Twins and Statistical Methods. In: Digital Twins Tools and Concepts for Smart Biomanufacturing, hg. von Christoph Herwig, Ralf Pörtner, und Johannes Möller, 176:97–131. Advances in Biochemical Engineering/Biotechnology. Berlin, Heidelberg: Springer. doi:https://doi.org/10.1007/10_2020_137, .' din1505-2-1: 'Hernández Rodriguez, Tanja ; Frahm, Björn: Digital Seed Train Twins and Statistical Methods. In: Herwig, C. ; Pörtner, R. ; Möller, J. (Hrsg.): Digital Twins Tools and Concepts for Smart Biomanufacturing, Advances in Biochemical Engineering/Biotechnology. Bd. 176. Berlin, Heidelberg : Springer, 2021, S. 97–131' havard: 'T. Hernández Rodriguez, B. Frahm, Digital Seed Train Twins and Statistical Methods, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021: pp. 97–131.' ieee: 'T. Hernández Rodriguez and B. Frahm, “Digital Seed Train Twins and Statistical Methods,” in Digital Twins Tools and Concepts for Smart Biomanufacturing, vol. 176, C. Herwig, R. Pörtner, and J. Möller, Eds. Berlin, Heidelberg: Springer, 2021, pp. 97–131. doi: https://doi.org/10.1007/10_2020_137.' mla: Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins and Statistical Methods.” Digital Twins Tools and Concepts for Smart Biomanufacturing, edited by Christoph Herwig et al., vol. 176, Springer, 2021, pp. 97–131, https://doi.org/10.1007/10_2020_137. short: 'T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021, pp. 97–131.' ufg: 'Hernández Rodriguez, Tanja/Frahm, Björn: Digital Seed Train Twins and Statistical Methods, in: Herwig, Christoph/Pörtner, Ralf/Möller, Johannes (Hgg.): Digital Twins Tools and Concepts for Smart Biomanufacturing, Bd. 176, Berlin, Heidelberg 2021 (Advances in Biochemical Engineering/Biotechnology), S. 97–131.' van: 'Hernández Rodriguez T, Frahm B. Digital Seed Train Twins and Statistical Methods. In: Herwig C, Pörtner R, Möller J, editors. Digital Twins Tools and Concepts for Smart Biomanufacturing. Berlin, Heidelberg: Springer; 2021. p. 97–131. (Advances in Biochemical Engineering/Biotechnology; vol. 176).' date_created: 2020-08-19T07:14:11Z date_updated: 2023-08-16T06:48:35Z department: - _id: DEP4021 doi: https://doi.org/10.1007/10_2020_137 editor: - first_name: 'Christoph ' full_name: 'Herwig, Christoph ' last_name: Herwig - first_name: 'Ralf ' full_name: 'Pörtner, Ralf ' last_name: Pörtner - first_name: 'Johannes ' full_name: 'Möller, Johannes ' last_name: Möller intvolume: ' 176' keyword: - Bayes - Digital twin - Parameter estimation - Seed train - Uncertainty language: - iso: eng page: 97–131 place: Berlin, Heidelberg publication: Digital Twins Tools and Concepts for Smart Biomanufacturing publication_identifier: eisbn: - 978-3-030-71660-8 eissn: - 1616-8542 isbn: - 978-3-030-71659-2 issn: - 0724-6145 publication_status: published publisher: Springer quality_controlled: '1' series_title: Advances in Biochemical Engineering/Biotechnology status: public title: Digital Seed Train Twins and Statistical Methods type: book_chapter user_id: '83781' volume: 176 year: '2021' ... --- _id: '7929' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Sahar full_name: Deppe, Sahar last_name: Deppe - first_name: Veronika full_name: Gassenmeier, Veronika id: '74048' last_name: Gassenmeier - first_name: Fabian full_name: Kuhfuß, Fabian last_name: Kuhfuß - first_name: Marius full_name: Tölle, Marius last_name: Tölle - first_name: George Adrian full_name: Ifrim, George Adrian id: '73814' last_name: Ifrim - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Deppe S, Gassenmeier V, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration.; 2020. apa: Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany. bjps: Hernández Rodriguez T et al. (2020) Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. . chicago: Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim, and Björn Frahm. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020. chicago-de: Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim und Björn Frahm. 2020. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. din1505-2-1: 'Hernández Rodriguez, Tanja ; Deppe, Sahar ; Gassenmeier, Veronika ; Kuhfuß, Fabian ; Tölle, Marius ; Ifrim, George Adrian ; Frahm, Björn: Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020' havard: T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020. ieee: T. Hernández Rodriguez et al., Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020. mla: Hernández Rodriguez, Tanja, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. 2020. short: T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020. ufg: 'Hernández Rodriguez, Tanja et. al. (2020): Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration.' van: Hernández Rodriguez T, Deppe S, Gassenmeier V, Kuhfuß F, Tölle M, Ifrim GA, et al. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020. conference: end_date: 2020-09-24 location: als Web-Konferenz, Aachen, Germany name: 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 start_date: 2020-09-21 date_created: 2022-05-04T19:22:33Z date_updated: 2023-03-15T13:50:12Z department: - _id: DEP4021 language: - iso: eng status: public title: Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration type: conference_poster user_id: '45673' year: 2020 ... --- _id: '7930' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Christoph full_name: Posch, Christoph last_name: Posch - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes.; 2020. apa: Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany. bjps: Hernández Rodriguez T et al. (2020) Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. . chicago: Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, and Björn Frahm. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020. chicago-de: Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner und Björn Frahm. 2020. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. din1505-2-1: 'Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020' havard: T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, 2020. ieee: T. Hernández Rodriguez, C. Posch, R. Pörtner, and B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. 2020. mla: Hernández Rodriguez, Tanja, et al. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. 2020. short: T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020. ufg: 'Hernández Rodriguez, Tanja et. al. (2020): Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes.' van: Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. 2020. conference: end_date: 2020-09-24 location: als Web-Konferenz, Aachen, Germany name: 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 start_date: 2020-09-21 date_created: 2022-05-04T19:26:13Z date_updated: 2023-03-15T13:50:12Z department: - _id: DEP4021 language: - iso: eng status: public title: Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes type: conference_poster user_id: '45666' year: 2020 ... --- _id: '7936' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Christoph full_name: Posch, Christoph last_name: Posch citation: ama: Hernández Rodriguez T, Frahm B, Posch C. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support.; 2020. apa: Hernández Rodriguez, T., Frahm, B., & Posch, C. (2020). Integration of prior knowledge and digital tools for uncertainty-based decision support. Presented at the 1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable, Sandoz, Austria. bjps: Hernández Rodriguez T, Frahm B and Posch C (2020) Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support. . chicago: Hernández Rodriguez, Tanja, Björn Frahm, and Christoph Posch. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support, 2020. chicago-de: Hernández Rodriguez, Tanja, Björn Frahm und Christoph Posch. 2020. Integration of prior knowledge and digital tools for uncertainty-based decision support. din1505-2-1: 'Hernández Rodriguez, Tanja ; Frahm, Björn ; Posch, Christoph: Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020' havard: T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of prior knowledge and digital tools for uncertainty-based decision support, 2020. ieee: T. Hernández Rodriguez, B. Frahm, and C. Posch, Integration of prior knowledge and digital tools for uncertainty-based decision support. 2020. mla: Hernández Rodriguez, Tanja, et al. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support. 2020. short: T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support, 2020. ufg: 'Hernández Rodriguez, Tanja et. al. (2020): Integration of prior knowledge and digital tools for uncertainty-based decision support.' van: Hernández Rodriguez T, Frahm B, Posch C. Integration of prior knowledge and digital tools for uncertainty-based decision support. 2020. conference: location: Sandoz, Austria name: 1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable start_date: 2020-06-03 date_created: 2022-05-04T19:47:05Z date_updated: 2023-03-15T13:50:12Z department: - _id: DEP4021 language: - iso: eng status: public title: Integration of prior knowledge and digital tools for uncertainty-based decision support type: conference_speech user_id: '45666' year: 2020 ... --- _id: '7937' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Sahar full_name: Deppe, Sahar last_name: Deppe - first_name: Veronika full_name: Gassenmeier, Veronika id: '74048' last_name: Gassenmeier - first_name: Fabian full_name: Kuhfuß, Fabian last_name: Kuhfuß - first_name: Marius full_name: Tölle, Marius last_name: Tölle - first_name: George Adrian full_name: Ifrim, George Adrian id: '73814' last_name: Ifrim - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Deppe S, Gassenmeier V, et al. Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration. Vol No. 9. Wiley; 2020:1225 – 1226. doi:10.1002/cite.202055235 apa: Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1225 – 1226). Wiley. https://doi.org/10.1002/cite.202055235 bjps: Hernández Rodriguez T et al. (2020) Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration. Wiley. chicago: Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim, and Björn Frahm. Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration. Chemie Ingenieur Technik, Tagungsband Zur 10. ProcessNet-Jahrestagung Und 34. DECHEMA-Jahrestagung Der Biotechnologen 2020. Vol. No. 9. Volume 92. Wiley, 2020. https://doi.org/10.1002/cite.202055235. chicago-de: Hernández Rodriguez, Tanja, Sahar Deppe, Veronika Gassenmeier, Fabian Kuhfuß, Marius Tölle, George Adrian Ifrim und Björn Frahm. 2020. Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020. Bd. No. 9. Volume 92. Wiley. doi:10.1002/cite.202055235, . din1505-2-1: 'Hernández Rodriguez, Tanja ; Deppe, Sahar ; Gassenmeier, Veronika ; Kuhfuß, Fabian ; Tölle, Marius ; Ifrim, George Adrian ; Frahm, Björn: Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration, Volume 92. Bd. No. 9 : Wiley, 2020' havard: T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration, Wiley, 2020. ieee: T. Hernández Rodriguez et al., Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration, vol. No. 9. Wiley, 2020, pp. 1225 – 1226. mla: Hernández Rodriguez, Tanja, et al. “Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration.” Chemie Ingenieur Technik, Tagungsband Zur 10. ProcessNet-Jahrestagung Und 34. DECHEMA-Jahrestagung Der Biotechnologen 2020, vol. No. 9, Wiley, 2020, pp. 1225 – 1226, doi:10.1002/cite.202055235. short: T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration, Wiley, 2020. ufg: 'Hernández Rodriguez, Tanja et. al. (2020): Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration (=Volume 92 No. 9).' van: Hernández Rodriguez T, Deppe S, Gassenmeier V, Kuhfuß F, Tölle M, Ifrim GA, et al. Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020. Wiley; 2020. (Volume 92; vol. No. 9). date_created: 2022-05-04T19:59:48Z date_updated: 2023-03-15T13:50:12Z department: - _id: DEP4021 doi: 10.1002/cite.202055235 language: - iso: eng page: 1225 – 1226 publication: Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 publisher: Wiley series_title: Volume 92 status: public title: Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration type: conference_editor_article user_id: '45673' volume: No. 9 year: 2020 ... --- _id: '7938' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Christoph full_name: Posch, Christoph last_name: Posch - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. Vol No. 9. Wiley; 2020:1241 – 1242. doi:10.1002/cite.202055234 apa: Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1241 – 1242). Wiley. https://doi.org/10.1002/cite.202055234 bjps: Hernández Rodriguez T et al. (2020) Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. Wiley. chicago: Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner, and Björn Frahm. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. Chemie Ingenieur Technik, Tagungsband Zur 10. ProcessNet-Jahrestagung Und 34. DECHEMA-Jahrestagung Der Biotechnologen 2020. Vol. No. 9. Volume 92. Wiley, 2020. https://doi.org/10.1002/cite.202055234. chicago-de: Hernández Rodriguez, Tanja, Christoph Posch, Ralf Pörtner und Björn Frahm. 2020. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020. Bd. No. 9. Volume 92. Wiley. doi:10.1002/cite.202055234, . din1505-2-1: 'Hernández Rodriguez, Tanja ; Posch, Christoph ; Pörtner, Ralf ; Frahm, Björn: Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, Volume 92. Bd. No. 9 : Wiley, 2020' havard: T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, Wiley, 2020. ieee: T. Hernández Rodriguez, C. Posch, R. Pörtner, and B. Frahm, Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes, vol. No. 9. Wiley, 2020, pp. 1241 – 1242. mla: Hernández Rodriguez, Tanja, et al. “Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes.” Chemie Ingenieur Technik, Tagungsband Zur 10. ProcessNet-Jahrestagung Und 34. DECHEMA-Jahrestagung Der Biotechnologen 2020, vol. No. 9, Wiley, 2020, pp. 1241 – 1242, doi:10.1002/cite.202055234. short: T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, Wiley, 2020. ufg: 'Hernández Rodriguez, Tanja et. al. (2020): Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes (=Volume 92 No. 9).' van: Hernández Rodriguez T, Posch C, Pörtner R, Frahm B. Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020. Wiley; 2020. (Volume 92; vol. No. 9). date_created: 2022-05-04T20:04:44Z date_updated: 2023-03-15T13:50:12Z department: - _id: DEP4021 doi: 10.1002/cite.202055234 language: - iso: eng page: 1241 – 1242 publication: Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 publisher: Wiley series_title: Volume 92 status: public title: Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes type: conference_editor_article user_id: '45666' volume: No. 9 year: 2020 ... --- _id: '2822' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Christoph full_name: Posch, Christoph last_name: Posch - first_name: Julia full_name: Schmutzhard, Julia last_name: Schmutzhard - first_name: 'Josef ' full_name: 'Stettner, Josef ' last_name: Stettner - first_name: ' Claus ' full_name: 'Weihs, Claus ' last_name: Weihs - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. Vol 14. BioMed Central; 2020:P408. doi:10.1186/s12919-020-00188-y apa: 'Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, Claus , Pörtner, R., & Frahm, B. (2020). Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BMC Proceedings (Vol. 14, p. P408). Copenhagen, Denmark.: BioMed Central. https://doi.org/10.1186/s12919-020-00188-y' bjps: Hernández Rodriguez T et al. (2020) Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BioMed Central. chicago: Hernández Rodriguez, Tanja, Christoph Posch, Julia Schmutzhard, Josef Stettner, Claus Weihs, Ralf Pörtner, and Björn Frahm. Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BMC Proceedings. Vol. 14. BioMed Central, 2020. https://doi.org/10.1186/s12919-020-00188-y. chicago-de: Hernández Rodriguez, Tanja, Christoph Posch, Julia Schmutzhard, Josef Stettner, Claus Weihs, Ralf Pörtner und Björn Frahm. 2020. Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BMC Proceedings. Bd. 14. BioMed Central. doi:10.1186/s12919-020-00188-y, . din1505-2-1: 'Hernández Rodriguez, Tanja ; Posch, Christoph ; Schmutzhard, Julia ; Stettner, Josef ; Weihs, Claus ; Pörtner, Ralf ; Frahm, Björn: Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. Bd. 14 : BioMed Central, 2020' havard: T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, Claus Weihs, R. Pörtner, B. Frahm, Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, BioMed Central, 2020. ieee: T. Hernández Rodriguez et al., Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, vol. 14. BioMed Central, 2020, p. P408. mla: Hernández Rodriguez, Tanja, et al. “Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach.” BMC Proceedings, vol. 14, BioMed Central, 2020, p. P408, doi:10.1186/s12919-020-00188-y. short: T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, Claus Weihs, R. Pörtner, B. Frahm, Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, BioMed Central, 2020. ufg: 'Hernández Rodriguez, Tanja et. al. (2020): Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach (= 14).' van: Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs Claus , Pörtner R, et al. Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. Vol. 14, BMC Proceedings. BioMed Central; 2020. conference: end_date: 2019-05-08 location: Copenhagen, Denmark. name: '26th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies' start_date: 2019-05-05 date_created: 2020-06-04T13:44:12Z date_updated: 2023-03-15T13:49:43Z department: - _id: DEP4021 doi: 10.1186/s12919-020-00188-y intvolume: ' 14' language: - iso: eng page: P408 publication: BMC Proceedings publication_identifier: issn: - 1753-6561 publication_status: published publisher: BioMed Central related_material: link: - relation: confirmation url: https://bmcproc.biomedcentral.com/articles/10.1186/s12919-020-00188-y status: public title: Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach type: conference_editor_article user_id: '45666' volume: 14 year: 2020 ... --- _id: '3007' author: - first_name: F. full_name: Kuhfuß, F. last_name: Kuhfuß - first_name: M. full_name: Tölle, M. last_name: Tölle - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Veronika full_name: Gassenmeier, Veronika id: '74048' last_name: Gassenmeier - first_name: S. full_name: Deppe, S. last_name: Deppe - first_name: George Adrian full_name: Ifrim, George Adrian id: '73814' last_name: Ifrim - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Kuhfuß F, Tölle M, Hernández Rodriguez T, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration.; 2020. apa: Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Deppe, S., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the BioProcessingDays 2020, Recklinghausen, Germany. bjps: Kuhfuß F et al. (2020) Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. . chicago: Kuhfuß, F., M. Tölle, Tanja Hernández Rodriguez, Veronika Gassenmeier, S. Deppe, George Adrian Ifrim, and Björn Frahm. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020. chicago-de: Kuhfuß, F., M. Tölle, Tanja Hernández Rodriguez, Veronika Gassenmeier, S. Deppe, George Adrian Ifrim und Björn Frahm. 2020. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. din1505-2-1: 'Kuhfuß, F. ; Tölle, M. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Deppe, S. ; Ifrim, George Adrian ; Frahm, Björn: Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020' havard: F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, S. Deppe, G.A. Ifrim, B. Frahm, Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration, 2020. ieee: F. Kuhfuß et al., Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020. mla: Kuhfuß, F., et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. 2020. short: F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, S. Deppe, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020. ufg: 'Kuhfuß, F. et. al. (2020): Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration.' van: Kuhfuß F, Tölle M, Hernández Rodriguez T, Gassenmeier V, Deppe S, Ifrim GA, et al. Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. 2020. conference: end_date: 2020-02-19 location: Recklinghausen, Germany name: BioProcessingDays 2020 start_date: 2020-02-17 date_created: 2020-06-23T13:08:09Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration type: conference_poster user_id: '45673' year: 2020 ... --- _id: '3008' author: - first_name: S. full_name: Deppe, S. last_name: Deppe - first_name: F. full_name: Kuhfuß, F. last_name: Kuhfuß - first_name: M. full_name: Tölle, M. last_name: Tölle - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Veronika full_name: Gassenmeier, Veronika id: '74048' last_name: Gassenmeier - first_name: George Adrian full_name: Ifrim, George Adrian id: '73814' last_name: Ifrim - first_name: J. full_name: Möller, J. last_name: Möller - first_name: 'R. ' full_name: 'Pörtner, R. ' last_name: Pörtner - first_name: A. full_name: Moser, A. last_name: Moser - first_name: V. C. full_name: Hass, V. C. last_name: Hass - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Deppe S, Kuhfuß F, Tölle M, et al. Model-Assisted Design of Experiments for Algae Cultivation.; 2020. apa: Deppe, S., Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Ifrim, G. A., … Frahm, B. (2020). Model-assisted Design of Experiments for algae cultivation. Presented at the BioProcessingDays 2020, Recklinghausen, Germany. bjps: Deppe S et al. (2020) Model-Assisted Design of Experiments for Algae Cultivation. . chicago: Deppe, S., F. Kuhfuß, M. Tölle, Tanja Hernández Rodriguez, Veronika Gassenmeier, George Adrian Ifrim, J. Möller, et al. Model-Assisted Design of Experiments for Algae Cultivation, 2020. chicago-de: Deppe, S., F. Kuhfuß, M. Tölle, Tanja Hernández Rodriguez, Veronika Gassenmeier, George Adrian Ifrim, J. Möller, u. a. 2020. Model-assisted Design of Experiments for algae cultivation. din1505-2-1: 'Deppe, S. ; Kuhfuß, F. ; Tölle, M. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Ifrim, George Adrian ; Möller, J. ; Pörtner, R. ; u. a.: Model-assisted Design of Experiments for algae cultivation, 2020' havard: S. Deppe, F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, J. Möller, R. Pörtner, A. Moser, V.C. Hass, B. Frahm, Model-assisted Design of Experiments for algae cultivation, 2020. ieee: S. Deppe et al., Model-assisted Design of Experiments for algae cultivation. 2020. mla: Deppe, S., et al. Model-Assisted Design of Experiments for Algae Cultivation. 2020. short: S. Deppe, F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, J. Möller, R. Pörtner, A. Moser, V.C. Hass, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2020. ufg: 'Deppe, S. et. al. (2020): Model-assisted Design of Experiments for algae cultivation.' van: Deppe S, Kuhfuß F, Tölle M, Hernández Rodriguez T, Gassenmeier V, Ifrim GA, et al. Model-assisted Design of Experiments for algae cultivation. 2020. conference: end_date: 2020-02-19 location: Recklinghausen, Germany name: BioProcessingDays 2020 start_date: 2020-02-17 date_created: 2020-06-23T13:11:27Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Model-assisted Design of Experiments for algae cultivation type: conference_poster user_id: '45673' year: 2020 ... --- _id: '3009' author: - first_name: George Adrian full_name: Ifrim, George Adrian id: '73814' last_name: Ifrim - first_name: S. full_name: Deppe, S. last_name: Deppe - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Veronika full_name: Gassenmeier, Veronika id: '74048' last_name: Gassenmeier - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production.; 2020. apa: Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2020). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the BioProcessingDays 2020, Recklinghausen, Germany. bjps: Ifrim GA et al. (2020) Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. . chicago: Ifrim, George Adrian, S. Deppe, Tanja Hernández Rodriguez, Veronika Gassenmeier, and Björn Frahm. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2020. chicago-de: Ifrim, George Adrian, S. Deppe, Tanja Hernández Rodriguez, Veronika Gassenmeier und Björn Frahm. 2020. Modeling of microalgae in an air-lift photobioreactor for biomass production. din1505-2-1: 'Ifrim, George Adrian ; Deppe, S. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Frahm, Björn: Modeling of microalgae in an air-lift photobioreactor for biomass production, 2020' havard: G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production, 2020. ieee: G. A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, and B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production. 2020. mla: Ifrim, George Adrian, et al. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. 2020. short: G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2020. ufg: 'Ifrim, George Adrian et. al. (2020): Modeling of microalgae in an air-lift photobioreactor for biomass production.' van: Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of microalgae in an air-lift photobioreactor for biomass production. 2020. conference: end_date: 2020-02-19 location: Recklinghausen, Germany name: BioProcessingDays 2020 start_date: 2020-02-17 date_created: 2020-06-23T13:13:19Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Modeling of microalgae in an air-lift photobioreactor for biomass production type: conference_poster user_id: '45673' year: 2020 ... --- _id: '2391' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Christoph full_name: Posch, Christoph last_name: Posch - first_name: Julia full_name: Schmutzhard, Julia last_name: Schmutzhard - first_name: Josef full_name: Stettner, Josef last_name: Stettner - first_name: Claus full_name: Weihs, Claus last_name: Weihs - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering. 2019;116(11):2944-2959. doi:10.1002/bit.27125 apa: Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, C., Pörtner, R., & Frahm, B. (2019). Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering, 116(11), 2944–2959. https://doi.org/10.1002/bit.27125 bjps: Hernández Rodriguez T et al. (2019) Predicting Industrial‐scale Cell Culture Seed Trains–A Bayesian Framework for Model Fitting and Parameter Estimation, Dealing with Uncertainty in Measurements and Model Parameters, Applied to a Nonlinear Kinetic Cell Culture Model, Using an MCMC Method. Biotechnology and Bioengineering 116, 2944–2959. chicago: 'Hernández Rodriguez, Tanja, Christoph Posch, Julia Schmutzhard, Josef Stettner, Claus Weihs, Ralf Pörtner, and Björn Frahm. “Predicting Industrial‐scale Cell Culture Seed Trains–A Bayesian Framework for Model Fitting and Parameter Estimation, Dealing with Uncertainty in Measurements and Model Parameters, Applied to a Nonlinear Kinetic Cell Culture Model, Using an MCMC Method.” Biotechnology and Bioengineering 116, no. 11 (2019): 2944–59. https://doi.org/10.1002/bit.27125.' chicago-de: 'Hernández Rodriguez, Tanja, Christoph Posch, Julia Schmutzhard, Josef Stettner, Claus Weihs, Ralf Pörtner und Björn Frahm. 2019. Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering 116, Nr. 11: 2944–2959. doi:10.1002/bit.27125, .' din1505-2-1: 'Hernández Rodriguez, Tanja ; Posch, Christoph ; Schmutzhard, Julia ; Stettner, Josef ; Weihs, Claus ; Pörtner, Ralf ; Frahm, Björn: Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. In: Biotechnology and Bioengineering Bd. 116, Wiley (2019), Nr. 11, S. 2944–2959' havard: T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, C. Weihs, R. Pörtner, B. Frahm, Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method, Biotechnology and Bioengineering. 116 (2019) 2944–2959. ieee: T. Hernández Rodriguez et al., “Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method,” Biotechnology and Bioengineering, vol. 116, no. 11, pp. 2944–2959, 2019. mla: Hernández Rodriguez, Tanja, et al. “Predicting Industrial‐scale Cell Culture Seed Trains–A Bayesian Framework for Model Fitting and Parameter Estimation, Dealing with Uncertainty in Measurements and Model Parameters, Applied to a Nonlinear Kinetic Cell Culture Model, Using an MCMC Method.” Biotechnology and Bioengineering, vol. 116, no. 11, Wiley, 2019, pp. 2944–59, doi:10.1002/bit.27125. short: T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, C. Weihs, R. Pörtner, B. Frahm, Biotechnology and Bioengineering 116 (2019) 2944–2959. ufg: 'Hernández Rodriguez, Tanja et. al. (2019): Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method, in: Biotechnology and Bioengineering 116 (11), S. 2944–2959.' van: Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs C, Pörtner R, et al. Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering. 2019;116(11):2944–59. date_created: 2020-05-19T14:29:12Z date_updated: 2023-03-15T13:49:39Z department: - _id: DEP4021 doi: 10.1002/bit.27125 intvolume: ' 116' issue: '11' language: - iso: eng main_file_link: - open_access: '1' url: https://onlinelibrary.wiley.com/doi/10.1002/bit.27125 oa: '1' page: 2944-2959 publication: Biotechnology and Bioengineering publication_identifier: eissn: - 1097-0290 issn: - 0006-3592 publication_status: published publisher: Wiley quality_controlled: '1' status: public title: Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method type: scientific_journal_article user_id: '45666' volume: 116 year: 2019 ... --- _id: '2956' author: - first_name: J. full_name: Möller, J. last_name: Möller - first_name: J. full_name: Müller, J. last_name: Müller - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: K. B. full_name: Kuchemüller, K. B. last_name: Kuchemüller - first_name: L. full_name: Arndt, L. last_name: Arndt - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: R. full_name: Eibl, R. last_name: Eibl - first_name: D. full_name: Eibl, D. last_name: Eibl - first_name: R. full_name: Pörtner, R. last_name: Pörtner citation: ama: Möller J, Müller J, Hernández Rodriguez T, et al. Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes.; 2019. apa: 'Möller, J., Müller, J., Hernández Rodriguez, T., Kuchemüller, K. B., Arndt, L., Frahm, B., … Pörtner, R. (2019). Workflow for model-assisted design and scale-up of biopharmaceutical production processes. Presented at the BioTech 2019 - Biopharmaceutical Manufacturing and Single-Use Technologies: Process intensification and continuous bioprocessing with single-use devices, Wädenswil, Switzerland.' bjps: Möller J et al. (2019) Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes. . chicago: Möller, J., J. Müller, Tanja Hernández Rodriguez, K. B. Kuchemüller, L. Arndt, Björn Frahm, R. Eibl, D. Eibl, and R. Pörtner. Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes, 2019. chicago-de: Möller, J., J. Müller, Tanja Hernández Rodriguez, K. B. Kuchemüller, L. Arndt, Björn Frahm, R. Eibl, D. Eibl und R. Pörtner. 2019. Workflow for model-assisted design and scale-up of biopharmaceutical production processes. din1505-2-1: 'Möller, J. ; Müller, J. ; Hernández Rodriguez, Tanja ; Kuchemüller, K. B. ; Arndt, L. ; Frahm, Björn ; Eibl, R. ; Eibl, D. ; u. a.: Workflow for model-assisted design and scale-up of biopharmaceutical production processes, 2019' havard: J. Möller, J. Müller, T. Hernández Rodriguez, K.B. Kuchemüller, L. Arndt, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Workflow for model-assisted design and scale-up of biopharmaceutical production processes, 2019. ieee: J. Möller et al., Workflow for model-assisted design and scale-up of biopharmaceutical production processes. 2019. mla: Möller, J., et al. Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes. 2019. short: J. Möller, J. Müller, T. Hernández Rodriguez, K.B. Kuchemüller, L. Arndt, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes, 2019. ufg: 'Möller, J. et. al. (2019): Workflow for model-assisted design and scale-up of biopharmaceutical production processes.' van: Möller J, Müller J, Hernández Rodriguez T, Kuchemüller KB, Arndt L, Frahm B, et al. Workflow for model-assisted design and scale-up of biopharmaceutical production processes. 2019. conference: end_date: 2019-07-04 location: Wädenswil, Switzerland name: 'BioTech 2019 - Biopharmaceutical Manufacturing and Single-Use Technologies: Process intensification and continuous bioprocessing with single-use devices' start_date: 2019-07-02 date_created: 2020-06-18T09:43:27Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Workflow for model-assisted design and scale-up of biopharmaceutical production processes type: conference_speech user_id: '45666' year: 2019 ... --- _id: '2957' author: - first_name: J. full_name: Möller, J. last_name: Möller - first_name: K. B. full_name: Kuchemüller, K. B. last_name: Kuchemüller - first_name: A. full_name: Moser, A. last_name: Moser - first_name: V. C. full_name: Hass, V. C. last_name: Hass - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: S. full_name: Deppe, S. last_name: Deppe - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: R. full_name: Pörtner, R. last_name: Pörtner citation: ama: Möller J, Kuchemüller KB, Moser A, et al. Model-Assisted Design of Experiments.; 2019. apa: Möller, J., Kuchemüller, K. B., Moser, A., Hass, V. C., Hernández Rodriguez, T., Deppe, S., … Pörtner, R. (2019). Model-Assisted Design of Experiments. Presented at the 5th European Congress of Applied Biotechnology, Florence, Italy. bjps: Möller J et al. (2019) Model-Assisted Design of Experiments. . chicago: Möller, J., K. B. Kuchemüller, A. Moser, V. C. Hass, Tanja Hernández Rodriguez, S. Deppe, Björn Frahm, and R. Pörtner. Model-Assisted Design of Experiments, 2019. chicago-de: Möller, J., K. B. Kuchemüller, A. Moser, V. C. Hass, Tanja Hernández Rodriguez, S. Deppe, Björn Frahm und R. Pörtner. 2019. Model-Assisted Design of Experiments. din1505-2-1: 'Möller, J. ; Kuchemüller, K. B. ; Moser, A. ; Hass, V. C. ; Hernández Rodriguez, Tanja ; Deppe, S. ; Frahm, Björn ; Pörtner, R.: Model-Assisted Design of Experiments, 2019' havard: J. Möller, K.B. Kuchemüller, A. Moser, V.C. Hass, T. Hernández Rodriguez, S. Deppe, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments, 2019. ieee: J. Möller et al., Model-Assisted Design of Experiments. 2019. mla: Möller, J., et al. Model-Assisted Design of Experiments. 2019. short: J. Möller, K.B. Kuchemüller, A. Moser, V.C. Hass, T. Hernández Rodriguez, S. Deppe, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments, 2019. ufg: 'Möller, J. et. al. (2019): Model-Assisted Design of Experiments.' van: Möller J, Kuchemüller KB, Moser A, Hass VC, Hernández Rodriguez T, Deppe S, et al. Model-Assisted Design of Experiments. 2019. conference: end_date: 2019-09-19 location: Florence, Italy name: 5th European Congress of Applied Biotechnology start_date: 2019--09-15 date_created: 2020-06-18T10:34:16Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Model-Assisted Design of Experiments type: conference_speech user_id: '45666' year: 2019 ... --- _id: '3000' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: C. full_name: Posch, C. last_name: Posch - first_name: J. full_name: Schmutzhard, J. last_name: Schmutzhard - first_name: J. full_name: Stettner, J. last_name: Stettner - first_name: J. full_name: Weihs, J. last_name: Weihs - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating.; 2019. apa: Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the BioProcessingDays 2019, Recklinghausen, Germany. bjps: Hernández Rodriguez T et al. (2019) Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. . chicago: Hernández Rodriguez, Tanja, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, and Björn Frahm. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019. chicago-de: Hernández Rodriguez, Tanja, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner und Björn Frahm. 2019. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. din1505-2-1: 'Hernández Rodriguez, Tanja ; Posch, C. ; Schmutzhard, J. ; Stettner, J. ; Weihs, J. ; Pörtner, R. ; Frahm, Björn: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019' havard: T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019. ieee: T. Hernández Rodriguez et al., Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019. mla: Hernández Rodriguez, Tanja, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. 2019. short: T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019. ufg: 'Hernández Rodriguez, Tanja et. al. (2019): Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating.' van: Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs J, Pörtner R, et al. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019. conference: end_date: 2019-02-20 location: Recklinghausen, Germany name: BioProcessingDays 2019 start_date: 2019-02-18 date_created: 2020-06-23T12:40:44Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating type: conference_poster user_id: '45666' year: 2019 ... --- _id: '3001' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: C. full_name: Posch, C. last_name: Posch - first_name: J. full_name: Schmutzhard, J. last_name: Schmutzhard - first_name: J. full_name: Stettner, J. last_name: Stettner - first_name: J. full_name: Weihs, J. last_name: Weihs - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating.; 2019. apa: 'Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the 26th Meeting of the European Society for Animal Cell Technology (ESACT): Cell culture technologies: bridging academia and industry to provide solutions for patients, Copenhagen, Denmark.' bjps: Hernández Rodriguez T et al. (2019) Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. . chicago: Hernández Rodriguez, Tanja, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, and Björn Frahm. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019. chicago-de: Hernández Rodriguez, Tanja, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner und Björn Frahm. 2019. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. din1505-2-1: 'Hernández Rodriguez, Tanja ; Posch, C. ; Schmutzhard, J. ; Stettner, J. ; Weihs, J. ; Pörtner, R. ; Frahm, Björn: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019' havard: T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019. ieee: T. Hernández Rodriguez et al., Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019. mla: Hernández Rodriguez, Tanja, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. 2019. short: T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019. ufg: 'Hernández Rodriguez, Tanja et. al. (2019): Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating.' van: Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs J, Pörtner R, et al. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019. conference: end_date: 2019-05-08 location: Copenhagen, Denmark name: '26th Meeting of the European Society for Animal Cell Technology (ESACT): Cell culture technologies: bridging academia and industry to provide solutions for patients' start_date: 2019-05-05 date_created: 2020-06-23T12:40:44Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating type: conference_poster user_id: '45666' year: 2019 ... --- _id: '3002' author: - first_name: J. full_name: Möller, J. last_name: Möller - first_name: K. B. full_name: Kuchemüller, K. B. last_name: Kuchemüller - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: S. full_name: Deppe, S. last_name: Deppe - first_name: George Adrian full_name: Ifrim, George Adrian id: '73814' last_name: Ifrim - first_name: A. full_name: Moser, A. last_name: Moser - first_name: V. C. full_name: Hass, V. C. last_name: Hass - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: R. full_name: Pörtner, R. last_name: Pörtner citation: ama: Möller J, Kuchemüller KB, Hernández Rodriguez T, et al. Model-Assisted Design of Experiments – Software Toolbox.; 2019. apa: Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Deppe, S., Ifrim, G. A., Moser, A., … Pörtner, R. (2019). Model-Assisted Design of Experiments – Software Toolbox. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany. bjps: Möller J et al. (2019) Model-Assisted Design of Experiments – Software Toolbox. . chicago: Möller, J., K. B. Kuchemüller, Tanja Hernández Rodriguez, S. Deppe, George Adrian Ifrim, A. Moser, V. C. Hass, Björn Frahm, and R. Pörtner. Model-Assisted Design of Experiments – Software Toolbox, 2019. chicago-de: Möller, J., K. B. Kuchemüller, Tanja Hernández Rodriguez, S. Deppe, George Adrian Ifrim, A. Moser, V. C. Hass, Björn Frahm und R. Pörtner. 2019. Model-Assisted Design of Experiments – Software Toolbox. din1505-2-1: 'Möller, J. ; Kuchemüller, K. B. ; Hernández Rodriguez, Tanja ; Deppe, S. ; Ifrim, George Adrian ; Moser, A. ; Hass, V. C. ; Frahm, Björn ; u. a.: Model-Assisted Design of Experiments – Software Toolbox, 2019' havard: J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, S. Deppe, G.A. Ifrim, A. Moser, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments – Software Toolbox, 2019. ieee: J. Möller et al., Model-Assisted Design of Experiments – Software Toolbox. 2019. mla: Möller, J., et al. Model-Assisted Design of Experiments – Software Toolbox. 2019. short: J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, S. Deppe, G.A. Ifrim, A. Moser, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments – Software Toolbox, 2019. ufg: 'Möller, J. et. al. (2019): Model-Assisted Design of Experiments – Software Toolbox.' van: Möller J, Kuchemüller KB, Hernández Rodriguez T, Deppe S, Ifrim GA, Moser A, et al. Model-Assisted Design of Experiments – Software Toolbox. 2019. conference: end_date: 2019-05-29 location: Hamburg, Germany name: DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing” start_date: 2019-05-27 date_created: 2020-06-23T12:46:33Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Model-Assisted Design of Experiments – Software Toolbox type: conference_poster user_id: '45673' year: 2019 ... --- _id: '3003' author: - first_name: S. full_name: Deppe, S. last_name: Deppe - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Veronika full_name: Gassenmeier, Veronika id: '74048' last_name: Gassenmeier - first_name: M. full_name: Tölle, M. last_name: Tölle - first_name: F. full_name: Kuhfuß, F. last_name: Kuhfuß - first_name: J. full_name: Möller, J. last_name: Möller - first_name: 'K. B. ' full_name: 'Kuchemüller, K. B. ' last_name: Kuchemüller - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: A. full_name: Moser, A. last_name: Moser - first_name: V. C. full_name: Hass, V. C. last_name: Hass - first_name: George Adrian full_name: Ifrim, George Adrian id: '73814' last_name: Ifrim - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Deppe S, Hernández Rodriguez T, Gassenmeier V, et al. Model-Assisted Design of Experiments for Algae Cultivation.; 2019. apa: Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., Tölle, M., Kuhfuß, F., Möller, J., … Frahm, B. (2019). Model-assisted Design of Experiments for algae cultivation. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany. bjps: Deppe S et al. (2019) Model-Assisted Design of Experiments for Algae Cultivation. . chicago: Deppe, S., Tanja Hernández Rodriguez, Veronika Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K. B. Kuchemüller, et al. Model-Assisted Design of Experiments for Algae Cultivation, 2019. chicago-de: Deppe, S., Tanja Hernández Rodriguez, Veronika Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K. B. Kuchemüller, u. a. 2019. Model-assisted Design of Experiments for algae cultivation. din1505-2-1: 'Deppe, S. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Tölle, M. ; Kuhfuß, F. ; Möller, J. ; Kuchemüller, K. B. ; Pörtner, R. ; u. a.: Model-assisted Design of Experiments for algae cultivation, 2019' havard: S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K.B. Kuchemüller, R. Pörtner, A. Moser, V.C. Hass, G.A. Ifrim, B. Frahm, Model-assisted Design of Experiments for algae cultivation, 2019. ieee: S. Deppe et al., Model-assisted Design of Experiments for algae cultivation. 2019. mla: Deppe, S., et al. Model-Assisted Design of Experiments for Algae Cultivation. 2019. short: S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K.B. Kuchemüller, R. Pörtner, A. Moser, V.C. Hass, G.A. Ifrim, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2019. ufg: 'Deppe, S. et. al. (2019): Model-assisted Design of Experiments for algae cultivation.' van: Deppe S, Hernández Rodriguez T, Gassenmeier V, Tölle M, Kuhfuß F, Möller J, et al. Model-assisted Design of Experiments for algae cultivation. 2019. conference: end_date: 2019-05-29 location: Hamburg, Germany name: DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing” start_date: 2019-05-27 date_created: 2020-06-23T12:52:41Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Model-assisted Design of Experiments for algae cultivation type: conference_poster user_id: '45673' year: 2019 ... --- _id: '3004' author: - first_name: George Adrian full_name: Ifrim, George Adrian id: '73814' last_name: Ifrim - first_name: S. full_name: Deppe, S. last_name: Deppe - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Veronika full_name: Gassenmeier, Veronika id: '74048' last_name: Gassenmeier - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production.; 2019. apa: Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2019). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany. bjps: Ifrim GA et al. (2019) Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. . chicago: Ifrim, George Adrian, S. Deppe, Tanja Hernández Rodriguez, Veronika Gassenmeier, and Björn Frahm. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2019. chicago-de: Ifrim, George Adrian, S. Deppe, Tanja Hernández Rodriguez, Veronika Gassenmeier und Björn Frahm. 2019. Modeling of microalgae in an air-lift photobioreactor for biomass production. din1505-2-1: 'Ifrim, George Adrian ; Deppe, S. ; Hernández Rodriguez, Tanja ; Gassenmeier, Veronika ; Frahm, Björn: Modeling of microalgae in an air-lift photobioreactor for biomass production, 2019' havard: G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production, 2019. ieee: G. A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, and B. Frahm, Modeling of microalgae in an air-lift photobioreactor for biomass production. 2019. mla: Ifrim, George Adrian, et al. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. 2019. short: G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2019. ufg: 'Ifrim, George Adrian et. al. (2019): Modeling of microalgae in an air-lift photobioreactor for biomass production.' van: Ifrim GA, Deppe S, Hernández Rodriguez T, Gassenmeier V, Frahm B. Modeling of microalgae in an air-lift photobioreactor for biomass production. 2019. conference: end_date: 2019-05-29 location: Hamburg, Germany name: DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing” start_date: 2019-05-27 date_created: 2020-06-23T12:55:44Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Modeling of microalgae in an air-lift photobioreactor for biomass production type: conference_poster user_id: '45673' year: 2019 ... --- _id: '3005' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: C. full_name: Posch, C. last_name: Posch - first_name: J. full_name: Schmutzhard, J. last_name: Schmutzhard - first_name: J. full_name: Stettner, J. last_name: Stettner - first_name: J. full_name: Weihs, J. last_name: Weihs - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Posch C, Schmutzhard J, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating.; 2019. apa: Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany. bjps: Hernández Rodriguez T et al. (2019) Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. . chicago: Hernández Rodriguez, Tanja, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, and Björn Frahm. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019. chicago-de: Hernández Rodriguez, Tanja, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner und Björn Frahm. 2019. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. din1505-2-1: 'Hernández Rodriguez, Tanja ; Posch, C. ; Schmutzhard, J. ; Stettner, J. ; Weihs, J. ; Pörtner, R. ; Frahm, Björn: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019' havard: T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating, 2019. ieee: T. Hernández Rodriguez et al., Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019. mla: Hernández Rodriguez, Tanja, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. 2019. short: T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019. ufg: 'Hernández Rodriguez, Tanja et. al. (2019): Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating.' van: Hernández Rodriguez T, Posch C, Schmutzhard J, Stettner J, Weihs J, Pörtner R, et al. Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. 2019. conference: end_date: 2019-05-29 location: Hamburg, Germany name: DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing” start_date: 2019-05-27 date_created: 2020-06-23T13:01:27Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating type: conference_poster user_id: '45666' year: 2019 ... --- _id: '7935' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Christoph full_name: Posch, Christoph last_name: Posch - first_name: Julia full_name: Schmutzhard, Julia last_name: Schmutzhard - first_name: Josef full_name: Stettner, Josef last_name: Stettner citation: ama: Hernández Rodriguez T, Frahm B, Posch C, Schmutzhard J, Stettner J. A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization.; 2018. apa: Hernández Rodriguez, T., Frahm, B., Posch, C., Schmutzhard, J., & Stettner, J. (2018). A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. Presented at the Sandoz, Kundl, Austria. bjps: Hernández Rodriguez T et al. (2018) A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization. . chicago: Hernández Rodriguez, Tanja, Björn Frahm, Christoph Posch, Julia Schmutzhard, and Josef Stettner. A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization, 2018. chicago-de: Hernández Rodriguez, Tanja, Björn Frahm, Christoph Posch, Julia Schmutzhard und Josef Stettner. 2018. A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. din1505-2-1: 'Hernández Rodriguez, Tanja ; Frahm, Björn ; Posch, Christoph ; Schmutzhard, Julia ; Stettner, Josef: A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization, 2018' havard: T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, J. Stettner, A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization, 2018. ieee: T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, and J. Stettner, A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. 2018. mla: Hernández Rodriguez, Tanja, et al. A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization. 2018. short: T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, J. Stettner, A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization, 2018. ufg: 'Hernández Rodriguez, Tanja et. al. (2018): A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization.' van: Hernández Rodriguez T, Frahm B, Posch C, Schmutzhard J, Stettner J. A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. 2018. conference: location: Kundl, Austria name: Sandoz start_date: 2018-04-10 date_created: 2022-05-04T19:44:35Z date_updated: 2023-03-15T13:50:12Z department: - _id: DEP4021 language: - iso: eng status: public title: A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization type: conference_speech user_id: '45666' year: 2018 ... --- _id: '2390' author: - first_name: J. full_name: Möller, J. last_name: Möller - first_name: 'K. B. ' full_name: 'Kuchemüller, K. B. ' last_name: Kuchemüller - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: V. C. full_name: Hass, V. C. last_name: Hass - first_name: 'R. ' full_name: 'Pörtner, R. ' last_name: Pörtner citation: ama: Möller J, Kuchemüller KB, Hernández Rodriguez T, Frahm B, Hass VC, Pörtner R. Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review. 2018;3:39-41. apa: Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Frahm, B., Hass, V. C., & Pörtner, R. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review, 3, 39–41. bjps: Möller J et al. (2018) Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review 3, 39–41. chicago: 'Möller, J., K. B. Kuchemüller, Tanja Hernández Rodriguez, Björn Frahm, V. C. Hass, and R. Pörtner. “Model-Assisted Design of Process Strategies for Cell Culture Processes.” American Pharmaceutical Review 3 (2018): 39–41.' chicago-de: 'Möller, J., K. B. Kuchemüller, Tanja Hernández Rodriguez, Björn Frahm, V. C. Hass und R. Pörtner. 2018. Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review 3: 39–41.' din1505-2-1: 'Möller, J. ; Kuchemüller, K. B. ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Hass, V. C. ; Pörtner, R. : Model-Assisted Design of Process Strategies for Cell Culture Processes. In: American Pharmaceutical Review Bd. 3, Russel (2018), S. 39–41' havard: J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design of Process Strategies for Cell Culture Processes, American Pharmaceutical Review. 3 (2018) 39–41. ieee: J. Möller, K. B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V. C. Hass, and R. Pörtner, “Model-Assisted Design of Process Strategies for Cell Culture Processes,” American Pharmaceutical Review, vol. 3, pp. 39–41, 2018. mla: Möller, J., et al. “Model-Assisted Design of Process Strategies for Cell Culture Processes.” American Pharmaceutical Review, vol. 3, Russel, 2018, pp. 39–41. short: J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, American Pharmaceutical Review 3 (2018) 39–41. ufg: 'Möller, J. et. al. (2018): Model-Assisted Design of Process Strategies for Cell Culture Processes, in: American Pharmaceutical Review 3, S. 39–41.' van: Möller J, Kuchemüller KB, Hernández Rodriguez T, Frahm B, Hass VC, Pörtner R. Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review. 2018;3:39–41. date_created: 2020-05-19T14:28:02Z date_updated: 2023-03-15T13:49:39Z department: - _id: DEP4021 intvolume: ' 3' language: - iso: eng main_file_link: - open_access: '1' url: https://www.americanpharmaceuticalreview.com/Featured-Articles/348715-Model-Assisted-Design-of-Process-Strategies-for-Cell-Culture-Processes/ oa: '1' page: 39-41 publication: American Pharmaceutical Review publication_identifier: issn: - 1099-8012 publication_status: published publisher: Russel status: public title: Model-Assisted Design of Process Strategies for Cell Culture Processes type: scientific_journal_article user_id: '45666' volume: 3 year: 2018 ... --- _id: '2821' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Susan full_name: Krull, Susan last_name: Krull - first_name: Volker C. full_name: Hass, Volker C. last_name: Hass - first_name: Johannes full_name: Möller, Johannes last_name: Möller - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. Vol 112. BioMed Central; 2018:P175. doi:10.1186/s12919-018-0097-x apa: 'Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2018). Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. BMC Proceedings (Vol. 112, p. P175). Lausanne, Switzerland: BioMed Central. https://doi.org/10.1186/s12919-018-0097-x' bjps: Hernández Rodriguez T et al. (2018) Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. BioMed Central. chicago: Hernández Rodriguez, Tanja, Susan Krull, Volker C. Hass, Johannes Möller, Ralf Pörtner, and Björn Frahm. Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. BMC Proceedings. Vol. 112. BioMed Central, 2018. https://doi.org/10.1186/s12919-018-0097-x. chicago-de: Hernández Rodriguez, Tanja, Susan Krull, Volker C. Hass, Johannes Möller, Ralf Pörtner und Björn Frahm. 2018. Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. BMC Proceedings. Bd. 112. BioMed Central. doi:10.1186/s12919-018-0097-x, . din1505-2-1: 'Hernández Rodriguez, Tanja ; Krull, Susan ; Hass, Volker C. ; Möller, Johannes ; Pörtner, Ralf ; Frahm, Björn: Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Bd. 112 : BioMed Central, 2018' havard: T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, BioMed Central, 2018. ieee: T. Hernández Rodriguez, S. Krull, V. C. Hass, J. Möller, R. Pörtner, and B. Frahm, Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, vol. 112. BioMed Central, 2018, p. P175. mla: Hernández Rodriguez, Tanja, et al. “Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization.” BMC Proceedings, vol. 112, BioMed Central, 2018, p. P175, doi:10.1186/s12919-018-0097-x. short: T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, BioMed Central, 2018. ufg: 'Hernández Rodriguez, Tanja et. al. (2018): Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization (= 112).' van: Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Vol. 112, BMC Proceedings. BioMed Central; 2018. conference: end_date: 2017-05-17 location: Lausanne, Switzerland name: '25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies' start_date: 2017-05-+14 date_created: 2020-06-04T13:44:12Z date_updated: 2023-03-15T13:49:43Z department: - _id: DEP4021 doi: 10.1186/s12919-018-0097-x intvolume: ' 112' language: - iso: eng page: P175 publication: BMC Proceedings publication_identifier: issn: - 1753-6561 publication_status: published publisher: BioMed Central related_material: link: - relation: original url: https://bmcproc.biomedcentral.com/articles/10.1186/s12919-018-0097-x#Sec182 status: public title: Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization type: conference_editor_article user_id: '45666' volume: 112 year: 2018 ... --- _id: '2997' author: - first_name: J. full_name: Möller, J. last_name: Möller - first_name: K. B. full_name: Kuchemüller, K. B. last_name: Kuchemüller - first_name: F. full_name: Freiberger, F. last_name: Freiberger - first_name: P. full_name: Levermann, P. last_name: Levermann - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: V. C. full_name: Hass, V. C. last_name: Hass - first_name: R. full_name: Pörtner, R. last_name: Pörtner citation: ama: Möller J, Kuchemüller KB, Freiberger F, et al. Model-Assisted Design and Optimization of Process Strategies.; 2018. apa: Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hernández Rodriguez, T., Frahm, B., … Pörtner, R. (2018). Model-Assisted Design and Optimization of Process Strategies. Presented at the BioProcessingDays 2018, Recklinghausen, Germany. bjps: Möller J et al. (2018) Model-Assisted Design and Optimization of Process Strategies. . chicago: Möller, J., K. B. Kuchemüller, F. Freiberger, P. Levermann, Tanja Hernández Rodriguez, Björn Frahm, V. C. Hass, and R. Pörtner. Model-Assisted Design and Optimization of Process Strategies, 2018. chicago-de: Möller, J., K. B. Kuchemüller, F. Freiberger, P. Levermann, Tanja Hernández Rodriguez, Björn Frahm, V. C. Hass und R. Pörtner. 2018. Model-Assisted Design and Optimization of Process Strategies. din1505-2-1: 'Möller, J. ; Kuchemüller, K. B. ; Freiberger, F. ; Levermann, P. ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Hass, V. C. ; Pörtner, R.: Model-Assisted Design and Optimization of Process Strategies, 2018' havard: J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design and Optimization of Process Strategies, 2018. ieee: J. Möller et al., Model-Assisted Design and Optimization of Process Strategies. 2018. mla: Möller, J., et al. Model-Assisted Design and Optimization of Process Strategies. 2018. short: J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design and Optimization of Process Strategies, 2018. ufg: 'Möller, J. et. al. (2018): Model-Assisted Design and Optimization of Process Strategies.' van: Möller J, Kuchemüller KB, Freiberger F, Levermann P, Hernández Rodriguez T, Frahm B, et al. Model-Assisted Design and Optimization of Process Strategies. 2018. conference: end_date: 2018-02-21 location: Recklinghausen, Germany name: BioProcessingDays 2018 start_date: 2018-02-19 date_created: 2020-06-23T12:29:45Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Model-Assisted Design and Optimization of Process Strategies type: conference_poster user_id: '45666' year: 2018 ... --- _id: '2999' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: J. full_name: Möller, J. last_name: Möller - first_name: K. B. full_name: Kuchemüller, K. B. last_name: Kuchemüller - first_name: F. full_name: Freiberger, F. last_name: Freiberger - first_name: P. full_name: Levermann, P. last_name: Levermann - first_name: V. C. full_name: Hass, V. C. last_name: Hass - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: R. full_name: Pörtner, R. last_name: Pörtner citation: ama: Hernández Rodriguez T, Möller J, Kuchemüller KB, et al. Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses.; 2018. apa: 'Hernández Rodriguez, T., Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hass, V. C., … Pörtner, R. (2018). Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. Presented at the 5th BioProScale Symposium: Innovative scale up and scale down for bioprocess intensification, Berlin, Germany.' bjps: Hernández Rodriguez T et al. (2018) Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. . chicago: Hernández Rodriguez, Tanja, J. Möller, K. B. Kuchemüller, F. Freiberger, P. Levermann, V. C. Hass, Björn Frahm, and R. Pörtner. Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018. chicago-de: Hernández Rodriguez, Tanja, J. Möller, K. B. Kuchemüller, F. Freiberger, P. Levermann, V. C. Hass, Björn Frahm und R. Pörtner. 2018. Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. din1505-2-1: 'Hernández Rodriguez, Tanja ; Möller, J. ; Kuchemüller, K. B. ; Freiberger, F. ; Levermann, P. ; Hass, V. C. ; Frahm, Björn ; Pörtner, R.: Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018' havard: T. Hernández Rodriguez, J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018. ieee: T. Hernández Rodriguez et al., Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. 2018. mla: Hernández Rodriguez, Tanja, et al. Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. 2018. short: T. Hernández Rodriguez, J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018. ufg: 'Hernández Rodriguez, Tanja et. al. (2018): Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses.' van: Hernández Rodriguez T, Möller J, Kuchemüller KB, Freiberger F, Levermann P, Hass VC, et al. Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. 2018. conference: end_date: 2018-03-22 location: Berlin, Germany name: '5th BioProScale Symposium: Innovative scale up and scale down for bioprocess intensification' start_date: 2018-03-20 date_created: 2020-06-23T12:34:51Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses type: conference_poster user_id: '45666' year: 2018 ... --- _id: '2920' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: S. full_name: Kern, S. last_name: Kern - first_name: O. full_name: Platas Barradas, O. last_name: Platas Barradas - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Kern S, Platas Barradas O, Pörtner R, Frahm B. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren.; 2017. apa: Hernández Rodriguez, T., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the 3. Lippischer Automatisierungstreff der Produktions- und Werkstofftechnik (LAT/PWT), Lemgo, Germany. bjps: Hernández Rodriguez T et al. (2017) Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. . chicago: Hernández Rodriguez, Tanja, S. Kern, O. Platas Barradas, R. Pörtner, and Björn Frahm. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017. chicago-de: Hernández Rodriguez, Tanja, S. Kern, O. Platas Barradas, R. Pörtner und Björn Frahm. 2017. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. din1505-2-1: 'Hernández Rodriguez, Tanja ; Kern, S. ; Platas Barradas, O. ; Pörtner, R. ; Frahm, Björn: Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017' havard: T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017. ieee: T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, and B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017. mla: Hernández Rodriguez, Tanja, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017. short: T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017. ufg: 'Hernández Rodriguez, Tanja et. al. (2017): Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren.' van: Hernández Rodriguez T, Kern S, Platas Barradas O, Pörtner R, Frahm B. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017. conference: location: Lemgo, Germany name: 3. Lippischer Automatisierungstreff der Produktions- und Werkstofftechnik (LAT/PWT) start_date: 2017-05-19 date_created: 2020-06-16T14:18:13Z date_updated: 2023-03-15T13:49:43Z department: - _id: DEP4021 language: - iso: ger publication_status: published status: public title: Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren type: conference_speech user_id: '45666' year: 2017 ... --- _id: '2921' author: - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: J. full_name: Möller, J. last_name: Möller - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: V. C. full_name: Hass, V. C. last_name: Hass citation: ama: Pörtner R, Möller J, Hernández Rodriguez T, Frahm B, Hass VC. Model-Assisted Design and Optimization of Biotechnological Processes.; 2017. apa: Pörtner, R., Möller, J., Hernández Rodriguez, T., Frahm, B., & Hass, V. C. (2017). Model-assisted design and optimization of biotechnological processes. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany. bjps: Pörtner R et al. (2017) Model-Assisted Design and Optimization of Biotechnological Processes. . chicago: Pörtner, R., J. Möller, Tanja Hernández Rodriguez, Björn Frahm, and V. C. Hass. Model-Assisted Design and Optimization of Biotechnological Processes, 2017. chicago-de: Pörtner, R., J. Möller, Tanja Hernández Rodriguez, Björn Frahm und V. C. Hass. 2017. Model-assisted design and optimization of biotechnological processes. din1505-2-1: 'Pörtner, R. ; Möller, J. ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Hass, V. C.: Model-assisted design and optimization of biotechnological processes, 2017' havard: R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, Model-assisted design and optimization of biotechnological processes, 2017. ieee: R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, and V. C. Hass, Model-assisted design and optimization of biotechnological processes. 2017. mla: Pörtner, R., et al. Model-Assisted Design and Optimization of Biotechnological Processes. 2017. short: R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, Model-Assisted Design and Optimization of Biotechnological Processes, 2017. ufg: 'Pörtner, R. et. al. (2017): Model-assisted design and optimization of biotechnological processes.' van: Pörtner R, Möller J, Hernández Rodriguez T, Frahm B, Hass VC. Model-assisted design and optimization of biotechnological processes. 2017. conference: end_date: 2017-05-24 location: Neu-Ulm, Germany name: DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production start_date: 2017-05-22 date_created: 2020-06-16T14:28:17Z date_updated: 2023-03-15T13:49:43Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Model-assisted design and optimization of biotechnological processes type: conference_speech user_id: '45666' year: 2017 ... --- _id: '2950' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: K. S. full_name: Koopmann, K. S. last_name: Koopmann - first_name: J. full_name: Klaes, J. last_name: Klaes - first_name: S. full_name: Kern, S. last_name: Kern - first_name: O. full_name: Platas Barradas, O. last_name: Platas Barradas - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Koopmann KS, Klaes J, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren.; 2017. apa: Hernández Rodriguez, T., Koopmann, K. S., Klaes, J., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the MATLAB EXPO, Track “Optimierungsaufgaben in der Praxis,” Munic, Germany. bjps: Hernández Rodriguez T et al. (2017) Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. . chicago: Hernández Rodriguez, Tanja, K. S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, and Björn Frahm. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017. chicago-de: Hernández Rodriguez, Tanja, K. S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner und Björn Frahm. 2017. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. din1505-2-1: 'Hernández Rodriguez, Tanja ; Koopmann, K. S. ; Klaes, J. ; Kern, S. ; Platas Barradas, O. ; Pörtner, R. ; Frahm, Björn: Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017' havard: T. Hernández Rodriguez, K.S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017. ieee: T. Hernández Rodriguez et al., Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017. mla: Hernández Rodriguez, Tanja, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017. short: T. Hernández Rodriguez, K.S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017. ufg: 'Hernández Rodriguez, Tanja et. al. (2017): Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren.' van: Hernández Rodriguez T, Koopmann KS, Klaes J, Kern S, Platas Barradas O, Pörtner R, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017. conference: location: Munic, Germany name: MATLAB EXPO, Track “Optimierungsaufgaben in der Praxis” start_date: 2017-06-27 date_created: 2020-06-18T09:31:40Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: ger publication_status: published status: public title: Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren type: conference_speech user_id: '45666' year: 2017 ... --- _id: '2994' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: K. S. full_name: Koopmann, K. S. last_name: Koopmann - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Koopmann KS, Pörtner R, Frahm B. Influence of Parameter Accuracies in Cell Culture Seed Train Simulations.; 2017. apa: Hernández Rodriguez, T., Koopmann, K. S., Pörtner, R., & Frahm, B. (2017). Influence of parameter accuracies in cell culture seed train simulations. Presented at the BioProcessingDays 2017, Recklinghausen, Germany. bjps: Hernández Rodriguez T et al. (2017) Influence of Parameter Accuracies in Cell Culture Seed Train Simulations. . chicago: Hernández Rodriguez, Tanja, K. S. Koopmann, R. Pörtner, and Björn Frahm. Influence of Parameter Accuracies in Cell Culture Seed Train Simulations, 2017. chicago-de: Hernández Rodriguez, Tanja, K. S. Koopmann, R. Pörtner und Björn Frahm. 2017. Influence of parameter accuracies in cell culture seed train simulations. din1505-2-1: 'Hernández Rodriguez, Tanja ; Koopmann, K. S. ; Pörtner, R. ; Frahm, Björn: Influence of parameter accuracies in cell culture seed train simulations, 2017' havard: T. Hernández Rodriguez, K.S. Koopmann, R. Pörtner, B. Frahm, Influence of parameter accuracies in cell culture seed train simulations, 2017. ieee: T. Hernández Rodriguez, K. S. Koopmann, R. Pörtner, and B. Frahm, Influence of parameter accuracies in cell culture seed train simulations. 2017. mla: Hernández Rodriguez, Tanja, et al. Influence of Parameter Accuracies in Cell Culture Seed Train Simulations. 2017. short: T. Hernández Rodriguez, K.S. Koopmann, R. Pörtner, B. Frahm, Influence of Parameter Accuracies in Cell Culture Seed Train Simulations, 2017. ufg: 'Hernández Rodriguez, Tanja et. al. (2017): Influence of parameter accuracies in cell culture seed train simulations.' van: Hernández Rodriguez T, Koopmann KS, Pörtner R, Frahm B. Influence of parameter accuracies in cell culture seed train simulations. 2017. conference: end_date: 2017-02-22 location: Recklinghausen, Germany name: BioProcessingDays 2017 start_date: 2017-02-20 date_created: 2020-06-22T14:35:09Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Influence of parameter accuracies in cell culture seed train simulations type: conference_poster user_id: '45666' year: 2017 ... --- _id: '2995' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: S. full_name: Krull, S. last_name: Krull - first_name: V. C. full_name: Hass, V. C. last_name: Hass - first_name: J. full_name: Möller, J. last_name: Möller - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization.; 2017. apa: 'Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the 25th Meeting of the European Society for Animal Cell Technology (ESACT): Cell technologies for innovative therapies, Lausanne, Switzerland.' bjps: Hernández Rodriguez T et al. (2017) Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. . chicago: Hernández Rodriguez, Tanja, S. Krull, V. C. Hass, J. Möller, R. Pörtner, and Björn Frahm. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017. chicago-de: Hernández Rodriguez, Tanja, S. Krull, V. C. Hass, J. Möller, R. Pörtner und Björn Frahm. 2017. Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. din1505-2-1: 'Hernández Rodriguez, Tanja ; Krull, S. ; Hass, V. C. ; Möller, J. ; Pörtner, R. ; Frahm, Björn: Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017' havard: T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017. ieee: T. Hernández Rodriguez, S. Krull, V. C. Hass, J. Möller, R. Pörtner, and B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. 2017. mla: Hernández Rodriguez, Tanja, et al. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. 2017. short: T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017. ufg: 'Hernández Rodriguez, Tanja et. al. (2017): Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization.' van: Hernández Rodriguez T, Krull S, Hass VC, Möller J, Pörtner R, Frahm B. Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. 2017. conference: end_date: 2017-05-17 location: Lausanne, Switzerland name: '25th Meeting of the European Society for Animal Cell Technology (ESACT): Cell technologies for innovative therapies' start_date: 2017-05-14 date_created: 2020-06-23T12:23:00Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization type: conference_poster user_id: '45666' year: 2017 ... --- _id: '2996' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: S. full_name: Krull, S. last_name: Krull - first_name: V. C. full_name: Hass, V. C. last_name: Hass - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Krull S, Hass VC, Pörtner R, Frahm B. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization.; 2017. apa: Hernández Rodriguez, T., Krull, S., Hass, V. C., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production,” Neu-Ulm, Germany. bjps: Hernández Rodriguez T et al. (2017) Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. . chicago: Hernández Rodriguez, Tanja, S. Krull, V. C. Hass, R. Pörtner, and Björn Frahm. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017. chicago-de: Hernández Rodriguez, Tanja, S. Krull, V. C. Hass, R. Pörtner und Björn Frahm. 2017. Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. din1505-2-1: 'Hernández Rodriguez, Tanja ; Krull, S. ; Hass, V. C. ; Pörtner, R. ; Frahm, Björn: Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017' havard: T. Hernández Rodriguez, S. Krull, V.C. Hass, R. Pörtner, B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization, 2017. ieee: T. Hernández Rodriguez, S. Krull, V. C. Hass, R. Pörtner, and B. Frahm, Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. 2017. mla: Hernández Rodriguez, Tanja, et al. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. 2017. short: T. Hernández Rodriguez, S. Krull, V.C. Hass, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017. ufg: 'Hernández Rodriguez, Tanja et. al. (2017): Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization.' van: Hernández Rodriguez T, Krull S, Hass VC, Pörtner R, Frahm B. Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. 2017. conference: end_date: 2017-05-24 location: Neu-Ulm, Germany name: DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production” start_date: 2017-05-22 date_created: 2020-06-23T12:26:07Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization type: conference_poster user_id: '45666' year: 2017 ... --- _id: '2992' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: S. full_name: Vörtler, S. last_name: Vörtler - first_name: S. full_name: Kern, S. last_name: Kern - first_name: O. full_name: Platas Barradas, O. last_name: Platas Barradas - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Vörtler S, Kern S, Platas Barradas O, Pörtner R, Frahm B. A Software Tool for Biopharmaceutical Seed Train Design and Optimization.; 2016. apa: Hernández Rodriguez, T., Vörtler, S., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2016). A software tool for biopharmaceutical seed train design and optimization. Presented at the BioProcessingDays 2016, Recklinghausen, Germany. bjps: Hernández Rodriguez T et al. (2016) A Software Tool for Biopharmaceutical Seed Train Design and Optimization. . chicago: Hernández Rodriguez, Tanja, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, and Björn Frahm. A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2016. chicago-de: Hernández Rodriguez, Tanja, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner und Björn Frahm. 2016. A software tool for biopharmaceutical seed train design and optimization. din1505-2-1: 'Hernández Rodriguez, Tanja ; Vörtler, S. ; Kern, S. ; Platas Barradas, O. ; Pörtner, R. ; Frahm, Björn: A software tool for biopharmaceutical seed train design and optimization, 2016' havard: T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, A software tool for biopharmaceutical seed train design and optimization, 2016. ieee: T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, and B. Frahm, A software tool for biopharmaceutical seed train design and optimization. 2016. mla: Hernández Rodriguez, Tanja, et al. A Software Tool for Biopharmaceutical Seed Train Design and Optimization. 2016. short: T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2016. ufg: 'Hernández Rodriguez, Tanja et. al. (2016): A software tool for biopharmaceutical seed train design and optimization.' van: Hernández Rodriguez T, Vörtler S, Kern S, Platas Barradas O, Pörtner R, Frahm B. A software tool for biopharmaceutical seed train design and optimization. 2016. conference: end_date: 2016-02-24 location: Recklinghausen, Germany name: BioProcessingDays 2016 start_date: 2016-02-22 date_created: 2020-06-22T14:23:50Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: A software tool for biopharmaceutical seed train design and optimization type: conference_poster user_id: '45666' year: 2016 ... --- _id: '2993' author: - first_name: K. S. full_name: Koopmann, K. S. last_name: Koopmann - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: S. full_name: Vörtler, S. last_name: Vörtler - first_name: U. full_name: Beshay, U. last_name: Beshay - first_name: J. full_name: Möller, J. last_name: Möller - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Koopmann KS, Hernández Rodriguez T, Vörtler S, et al. Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies.; 2016. apa: Koopmann, K. S., Hernández Rodriguez, T., Vörtler, S., Beshay, U., Möller, J., Pörtner, R., & Frahm, B. (2016). Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. Presented at the DECHEMA Himmelfahrtstagung “New Frontiers for Biotech-Processes,” Koblenz, Germany. bjps: Koopmann KS et al. (2016) Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies. . chicago: Koopmann, K. S., Tanja Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, and Björn Frahm. Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies, 2016. chicago-de: Koopmann, K. S., Tanja Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner und Björn Frahm. 2016. Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. din1505-2-1: 'Koopmann, K. S. ; Hernández Rodriguez, Tanja ; Vörtler, S. ; Beshay, U. ; Möller, J. ; Pörtner, R. ; Frahm, Björn: Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies, 2016' havard: K.S. Koopmann, T. Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, B. Frahm, Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies, 2016. ieee: K. S. Koopmann et al., Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. 2016. mla: Koopmann, K. S., et al. Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies. 2016. short: K.S. Koopmann, T. Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, B. Frahm, Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies, 2016. ufg: 'Koopmann, K. S. et. al. (2016): Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies.' van: Koopmann KS, Hernández Rodriguez T, Vörtler S, Beshay U, Möller J, Pörtner R, et al. Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. 2016. conference: end_date: 2016-05-04 location: Koblenz, Germany name: DECHEMA Himmelfahrtstagung “New Frontiers for Biotech-Processes” start_date: 2016-05-02 date_created: 2020-06-22T14:32:13Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies type: conference_poster user_id: '45666' year: 2016 ... --- _id: '2819' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for Cell Passaging in Cell Culture Seed Trains. Vol 9. BioMed Central; 2015. doi:10.1186/1753-6561-9-s9-p43 apa: Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. BMC proceedings / BioMed Central (Vol. 9). BioMed Central. https://doi.org/10.1186/1753-6561-9-s9-p43 bjps: Hernández Rodriguez T, Pörtner R and Frahm B (2015) Considerations for Cell Passaging in Cell Culture Seed Trains. BioMed Central. chicago: Hernández Rodriguez, Tanja, Ralf Pörtner, and Björn Frahm. Considerations for Cell Passaging in Cell Culture Seed Trains. BMC Proceedings / BioMed Central. Vol. 9. BioMed Central, 2015. https://doi.org/10.1186/1753-6561-9-s9-p43. chicago-de: Hernández Rodriguez, Tanja, Ralf Pörtner und Björn Frahm. 2015. Considerations for cell passaging in cell culture seed trains. BMC proceedings / BioMed Central. Bd. 9. BioMed Central. doi:10.1186/1753-6561-9-s9-p43, . din1505-2-1: 'Hernández Rodriguez, Tanja ; Pörtner, Ralf ; Frahm, Björn: Considerations for cell passaging in cell culture seed trains. Bd. 9 : BioMed Central, 2015' havard: T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, BioMed Central, 2015. ieee: T. Hernández Rodriguez, R. Pörtner, and B. Frahm, Considerations for cell passaging in cell culture seed trains, vol. 9. BioMed Central, 2015. mla: Hernández Rodriguez, Tanja, et al. “Considerations for Cell Passaging in Cell Culture Seed Trains.” BMC Proceedings / BioMed Central, vol. 9, BioMed Central, 2015, doi:10.1186/1753-6561-9-s9-p43. short: T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, BioMed Central, 2015. ufg: 'Hernández Rodriguez, Tanja et. al. (2015): Considerations for cell passaging in cell culture seed trains (= 9).' van: Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for cell passaging in cell culture seed trains. Vol. 9, BMC proceedings / BioMed Central. BioMed Central; 2015. date_created: 2020-06-04T13:39:24Z date_updated: 2023-03-15T13:49:43Z department: - _id: DEP4021 doi: 10.1186/1753-6561-9-s9-p43 intvolume: ' 9' language: - iso: eng main_file_link: - open_access: '1' url: https://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-9-S9-P43 oa: '1' publication: BMC proceedings / BioMed Central publication_identifier: eissn: - 1753-6561 publication_status: published publisher: BioMed Central status: public title: Considerations for cell passaging in cell culture seed trains type: conference_editor_article user_id: '45666' volume: 9 year: 2015 ... --- _id: '2917' author: - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: S. full_name: Kern, S. last_name: Kern - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez citation: ama: Frahm B, Pörtner R, Kern S, Hernández Rodriguez T. Seed Train Design and Optimization for Animal Cell Suspension Culture.; 2015. apa: Frahm, B., Pörtner, R., Kern, S., & Hernández Rodriguez, T. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the ACHEMA 2015, Frankfurt am Main, Germany. bjps: Frahm B et al. (2015) Seed Train Design and Optimization for Animal Cell Suspension Culture. . chicago: Frahm, Björn, R. Pörtner, S. Kern, and Tanja Hernández Rodriguez. Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015. chicago-de: Frahm, Björn, R. Pörtner, S. Kern und Tanja Hernández Rodriguez. 2015. Seed train design and optimization for animal cell suspension culture. din1505-2-1: 'Frahm, Björn ; Pörtner, R. ; Kern, S. ; Hernández Rodriguez, Tanja: Seed train design and optimization for animal cell suspension culture, 2015' havard: B. Frahm, R. Pörtner, S. Kern, T. Hernández Rodriguez, Seed train design and optimization for animal cell suspension culture, 2015. ieee: B. Frahm, R. Pörtner, S. Kern, and T. Hernández Rodriguez, Seed train design and optimization for animal cell suspension culture. 2015. mla: Frahm, Björn, et al. Seed Train Design and Optimization for Animal Cell Suspension Culture. 2015. short: B. Frahm, R. Pörtner, S. Kern, T. Hernández Rodriguez, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015. ufg: 'Frahm, Björn et. al. (2015): Seed train design and optimization for animal cell suspension culture.' van: Frahm B, Pörtner R, Kern S, Hernández Rodriguez T. Seed train design and optimization for animal cell suspension culture. 2015. conference: end_date: 2015-06-19 location: Frankfurt am Main, Germany name: ACHEMA 2015 start_date: 2015-06-15 date_created: 2020-06-15T14:12:09Z date_updated: 2023-03-15T13:49:43Z department: - _id: DEP4021 language: - iso: eng publication_status: published related_material: link: - relation: other url: https://www.process.vogel.de/heftarchiv/?k=&p=1&y=2015&s=2 status: public title: Seed train design and optimization for animal cell suspension culture type: conference_speech user_id: '45666' year: 2015 ... --- _id: '2919' author: - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: S. full_name: Kern, S. last_name: Kern - first_name: K. S. full_name: Koopmann, K. S. last_name: Koopmann - first_name: U. full_name: Beshay, U. last_name: Beshay - first_name: O. full_name: Platas-Barradas, O. last_name: Platas-Barradas - first_name: R. full_name: Pörtner, R. last_name: Pörtner citation: ama: Frahm B, Hernández Rodriguez T, Kern S, et al. Seed Train Design and Optimization for Animal Cell Suspension Culture.; 2015. apa: Frahm, B., Hernández Rodriguez, T., Kern, S., Koopmann, K. S., Beshay, U., Platas-Barradas, O., & Pörtner, R. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg, Germany. bjps: Frahm B et al. (2015) Seed Train Design and Optimization for Animal Cell Suspension Culture. . chicago: Frahm, Björn, Tanja Hernández Rodriguez, S. Kern, K. S. Koopmann, U. Beshay, O. Platas-Barradas, and R. Pörtner. Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015. chicago-de: Frahm, Björn, Tanja Hernández Rodriguez, S. Kern, K. S. Koopmann, U. Beshay, O. Platas-Barradas und R. Pörtner. 2015. Seed train design and optimization for animal cell suspension culture. din1505-2-1: 'Frahm, Björn ; Hernández Rodriguez, Tanja ; Kern, S. ; Koopmann, K. S. ; Beshay, U. ; Platas-Barradas, O. ; Pörtner, R.: Seed train design and optimization for animal cell suspension culture, 2015' havard: B. Frahm, T. Hernández Rodriguez, S. Kern, K.S. Koopmann, U. Beshay, O. Platas-Barradas, R. Pörtner, Seed train design and optimization for animal cell suspension culture, 2015. ieee: B. Frahm et al., Seed train design and optimization for animal cell suspension culture. 2015. mla: Frahm, Björn, et al. Seed Train Design and Optimization for Animal Cell Suspension Culture. 2015. short: B. Frahm, T. Hernández Rodriguez, S. Kern, K.S. Koopmann, U. Beshay, O. Platas-Barradas, R. Pörtner, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015. ufg: 'Frahm, Björn et. al. (2015): Seed train design and optimization for animal cell suspension culture.' van: Frahm B, Hernández Rodriguez T, Kern S, Koopmann KS, Beshay U, Platas-Barradas O, et al. Seed train design and optimization for animal cell suspension culture. 2015. conference: location: Magdeburg, Germany name: Max-Planck-Institut für Dynamik komplexer technischer Systeme start_date: 2015-07-13 date_created: 2020-06-16T14:09:07Z date_updated: 2023-03-15T13:49:43Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Seed train design and optimization for animal cell suspension culture type: conference_speech user_id: '45666' year: 2015 ... --- _id: '2985' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for Cell Passaging in Cell Culture Seed Trains.; 2015. apa: Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses,” Hamburg, Germany. bjps: Hernández Rodriguez T, Pörtner R and Frahm B (2015) Considerations for Cell Passaging in Cell Culture Seed Trains. . chicago: Hernández Rodriguez, Tanja, R. Pörtner, and Björn Frahm. Considerations for Cell Passaging in Cell Culture Seed Trains, 2015. chicago-de: Hernández Rodriguez, Tanja, R. Pörtner und Björn Frahm. 2015. Considerations for cell passaging in cell culture seed trains. din1505-2-1: 'Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: Considerations for cell passaging in cell culture seed trains, 2015' havard: T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, 2015. ieee: T. Hernández Rodriguez, R. Pörtner, and B. Frahm, Considerations for cell passaging in cell culture seed trains. 2015. mla: Hernández Rodriguez, Tanja, et al. Considerations for Cell Passaging in Cell Culture Seed Trains. 2015. short: T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015. ufg: 'Hernández Rodriguez, Tanja et. al. (2015): Considerations for cell passaging in cell culture seed trains.' van: Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for cell passaging in cell culture seed trains. 2015. conference: end_date: 2015-05-13 location: Hamburg, Germany name: DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses” start_date: 2015-05-11 date_created: 2020-06-22T13:35:55Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Considerations for cell passaging in cell culture seed trains type: conference_poster user_id: '45666' year: 2015 ... --- _id: '2987' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Pörtner R, Frahm B. A Software Tool for Biopharmaceutical Seed Train Design and Optimization.; 2015. apa: Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). A software tool for biopharmaceutical seed train design and optimization. Presented at the MATLAB EXPO, Munic, Germany. bjps: Hernández Rodriguez T, Pörtner R and Frahm B (2015) A Software Tool for Biopharmaceutical Seed Train Design and Optimization. . chicago: Hernández Rodriguez, Tanja, R. Pörtner, and Björn Frahm. A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2015. chicago-de: Hernández Rodriguez, Tanja, R. Pörtner und Björn Frahm. 2015. A software tool for biopharmaceutical seed train design and optimization. din1505-2-1: 'Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: A software tool for biopharmaceutical seed train design and optimization, 2015' havard: T. Hernández Rodriguez, R. Pörtner, B. Frahm, A software tool for biopharmaceutical seed train design and optimization, 2015. ieee: T. Hernández Rodriguez, R. Pörtner, and B. Frahm, A software tool for biopharmaceutical seed train design and optimization. 2015. mla: Hernández Rodriguez, Tanja, et al. A Software Tool for Biopharmaceutical Seed Train Design and Optimization. 2015. short: T. Hernández Rodriguez, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2015. ufg: 'Hernández Rodriguez, Tanja et. al. (2015): A software tool for biopharmaceutical seed train design and optimization.' van: Hernández Rodriguez T, Pörtner R, Frahm B. A software tool for biopharmaceutical seed train design and optimization. 2015. conference: location: Munic, Germany name: MATLAB EXPO start_date: 2015-05-12 date_created: 2020-06-22T13:42:30Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: A software tool for biopharmaceutical seed train design and optimization type: conference_poster user_id: '45666' year: 2015 ... --- _id: '2988' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for Cell Passaging in Cell Culture Seed Trains.; 2015. apa: 'Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the 24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products, Barcelona, Spain.' bjps: Hernández Rodriguez T, Pörtner R and Frahm B (2015) Considerations for Cell Passaging in Cell Culture Seed Trains. . chicago: Hernández Rodriguez, Tanja, R. Pörtner, and Björn Frahm. Considerations for Cell Passaging in Cell Culture Seed Trains, 2015. chicago-de: Hernández Rodriguez, Tanja, R. Pörtner und Björn Frahm. 2015. Considerations for cell passaging in cell culture seed trains. din1505-2-1: 'Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: Considerations for cell passaging in cell culture seed trains, 2015' havard: T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for cell passaging in cell culture seed trains, 2015. ieee: T. Hernández Rodriguez, R. Pörtner, and B. Frahm, Considerations for cell passaging in cell culture seed trains. 2015. mla: Hernández Rodriguez, Tanja, et al. Considerations for Cell Passaging in Cell Culture Seed Trains. 2015. short: T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015. ufg: 'Hernández Rodriguez, Tanja et. al. (2015): Considerations for cell passaging in cell culture seed trains.' van: Hernández Rodriguez T, Pörtner R, Frahm B. Considerations for cell passaging in cell culture seed trains. 2015. conference: end_date: 2015-06-03 location: Barcelona, Spain name: '24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products' start_date: 2015-05-31 date_created: 2020-06-22T13:48:01Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Considerations for cell passaging in cell culture seed trains type: conference_poster user_id: '45666' year: 2015 ... --- _id: '2817' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Ralf full_name: Pörtner, Ralf last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Pörtner R, Frahm B. Seed Train Optimization for Suspension Cell Culture. Vol 7. BioMed Central ; 2013. doi:10.1186/1753-6561-7-s6-p9 apa: Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. BMC proceedings / BioMed Central (Vol. 7). BioMed Central . https://doi.org/10.1186/1753-6561-7-s6-p9 bjps: Hernández Rodriguez T, Pörtner R and Frahm B (2013) Seed Train Optimization for Suspension Cell Culture. BioMed Central . chicago: Hernández Rodriguez, Tanja, Ralf Pörtner, and Björn Frahm. Seed Train Optimization for Suspension Cell Culture. BMC Proceedings / BioMed Central . Vol. 7. BioMed Central , 2013. https://doi.org/10.1186/1753-6561-7-s6-p9. chicago-de: Hernández Rodriguez, Tanja, Ralf Pörtner und Björn Frahm. 2013. Seed train optimization for suspension cell culture. BMC proceedings / BioMed Central . Bd. 7. BioMed Central . doi:10.1186/1753-6561-7-s6-p9, . din1505-2-1: 'Hernández Rodriguez, Tanja ; Pörtner, Ralf ; Frahm, Björn: Seed train optimization for suspension cell culture. Bd. 7 : BioMed Central , 2013' havard: T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, BioMed Central , 2013. ieee: T. Hernández Rodriguez, R. Pörtner, and B. Frahm, Seed train optimization for suspension cell culture, vol. 7. BioMed Central , 2013. mla: Hernández Rodriguez, Tanja, et al. “Seed Train Optimization for Suspension Cell Culture.” BMC Proceedings / BioMed Central , vol. 7, BioMed Central , 2013, doi:10.1186/1753-6561-7-s6-p9. short: T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, BioMed Central , 2013. ufg: 'Hernández Rodriguez, Tanja et. al. (2013): Seed train optimization for suspension cell culture (= 7).' van: Hernández Rodriguez T, Pörtner R, Frahm B. Seed train optimization for suspension cell culture. Vol. 7, BMC proceedings / BioMed Central . BioMed Central ; 2013. date_created: 2020-06-04T13:27:04Z date_updated: 2023-03-15T13:49:43Z department: - _id: DEP4021 doi: 10.1186/1753-6561-7-s6-p9 intvolume: ' 7' language: - iso: eng main_file_link: - open_access: '1' url: https://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-7-S6-P9 oa: '1' publication: 'BMC proceedings / BioMed Central ' publication_identifier: issn: - 1753-6561 publication_status: published publisher: 'BioMed Central ' status: public title: Seed train optimization for suspension cell culture type: conference_editor_article user_id: '45666' volume: 7 year: 2013 ... --- _id: '2983' author: - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: R. full_name: Pörtner, R. last_name: Pörtner - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm citation: ama: Hernández Rodriguez T, Pörtner R, Frahm B. Seed Train Optimization for Suspension Cell Culture.; 2013. apa: 'Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.' bjps: Hernández Rodriguez T, Pörtner R and Frahm B (2013) Seed Train Optimization for Suspension Cell Culture. . chicago: Hernández Rodriguez, Tanja, R. Pörtner, and Björn Frahm. Seed Train Optimization for Suspension Cell Culture, 2013. chicago-de: Hernández Rodriguez, Tanja, R. Pörtner und Björn Frahm. 2013. Seed train optimization for suspension cell culture. din1505-2-1: 'Hernández Rodriguez, Tanja ; Pörtner, R. ; Frahm, Björn: Seed train optimization for suspension cell culture, 2013' havard: T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed train optimization for suspension cell culture, 2013. ieee: T. Hernández Rodriguez, R. Pörtner, and B. Frahm, Seed train optimization for suspension cell culture. 2013. mla: Hernández Rodriguez, Tanja, et al. Seed Train Optimization for Suspension Cell Culture. 2013. short: T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, 2013. ufg: 'Hernández Rodriguez, Tanja et. al. (2013): Seed train optimization for suspension cell culture.' van: Hernández Rodriguez T, Pörtner R, Frahm B. Seed train optimization for suspension cell culture. 2013. conference: end_date: 2013-06-26 location: Lille, France name: '23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health' start_date: 2013-06-23 date_created: 2020-06-22T13:28:40Z date_updated: 2023-03-15T13:49:44Z department: - _id: DEP4021 language: - iso: eng publication_status: published status: public title: Seed train optimization for suspension cell culture type: conference_poster user_id: '45666' year: 2013 ...