--- _id: '13475' abstract: - lang: eng text: In the context of data-driven bioprocess modeling, selecting appropriate regression models remains a critical challenge. This is especially the case when dealing with time-dependent process dynamics and complex measurement data. The practical relevance of this study lies in its critical assessment of the application constraints associated with multivariate linear regression models in bioprocess monitoring of cell culture processes. The applicability of Partial Least Squares and Ridge regression was evaluated for different cultivation phases. The results emphasize that no single linear modeling approach is universally suitable for capturing the complex behavior of mammalian cell cultures. This is why we present an enhanced segmented modeling approach by learning the optimal transition point from data and introducing a gradual model switch, allowing for smoother and more robust adaptation to process dynamics. This segmented model led to improved predictive performance compared to single-model regression across the entire process duration. Nevertheless, the heterogeneity of the 11 mammalian cell culture datasets used in this study posed significant challenges, with the best-performing models achieving prediction error of around 0.31 of the average offline viable cell density. These results underline the potential of phase-adaptive modeling, while also emphasizing the need for further optimization to robustly handle diverse bioprocess conditions. author: - first_name: Selina full_name: Uhlendorff, Selina id: '68713' last_name: Uhlendorff orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Tatsiana full_name: Burankova, Tatsiana last_name: Burankova - first_name: Katharina full_name: Dahlmann, Katharina last_name: Dahlmann - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Uhlendorff S, Burankova T, Dahlmann K, Frahm B, Pein-Hackelbusch M. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. IEEE; 2026:34-39. doi:10.1109/iwis69004.2025.11339388 apa: Uhlendorff, S., Burankova, T., Dahlmann, K., Frahm, B., & Pein-Hackelbusch, M. (2026). Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. In 2025 International Workshop on Impedance Spectroscopy (IWIS) (pp. 34–39). IEEE. https://doi.org/10.1109/iwis69004.2025.11339388 bjps: 'Uhlendorff S et al. (2026) Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. New York: IEEE.' chicago: 'Uhlendorff, Selina, Tatsiana Burankova, Katharina Dahlmann, Björn Frahm, and Miriam Pein-Hackelbusch. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. 2025 International Workshop on Impedance Spectroscopy (IWIS). New York: IEEE, 2026. https://doi.org/10.1109/iwis69004.2025.11339388.' chicago-de: 'Uhlendorff, Selina, Tatsiana Burankova, Katharina Dahlmann, Björn Frahm und Miriam Pein-Hackelbusch. 2026. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. 2025 International Workshop on Impedance Spectroscopy (IWIS). New York: IEEE. doi:10.1109/iwis69004.2025.11339388, .' din1505-2-1: 'Uhlendorff, Selina ; Burankova, Tatsiana ; Dahlmann, Katharina ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. New York : IEEE, 2026' havard: S. Uhlendorff, T. Burankova, K. Dahlmann, B. Frahm, M. Pein-Hackelbusch, Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, IEEE, New York, 2026. ieee: 'S. Uhlendorff, T. Burankova, K. Dahlmann, B. Frahm, and M. Pein-Hackelbusch, Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. New York: IEEE, 2026, pp. 34–39. doi: 10.1109/iwis69004.2025.11339388.' mla: Uhlendorff, Selina, et al. “Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis.” 2025 International Workshop on Impedance Spectroscopy (IWIS), IEEE, 2026, pp. 34–39, https://doi.org/10.1109/iwis69004.2025.11339388. short: S. Uhlendorff, T. Burankova, K. Dahlmann, B. Frahm, M. Pein-Hackelbusch, Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, IEEE, New York, 2026. ufg: 'Uhlendorff, Selina u. a.: Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, New York 2026.' van: 'Uhlendorff S, Burankova T, Dahlmann K, Frahm B, Pein-Hackelbusch M. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. 2025 International Workshop on Impedance Spectroscopy (IWIS). New York: IEEE; 2026.' conference: end_date: 2025-09-26 location: Chemnitz name: 2025 International Workshop on Impedance Spectroscopy (IWIS) start_date: 2025-09-23 date_created: 2026-03-06T08:52:51Z date_updated: 2026-04-08T11:28:18Z department: - _id: DEP4028 doi: 10.1109/iwis69004.2025.11339388 keyword: - cell culture - impedance spectroscopy - partial least squares - ridge regression language: - iso: eng page: 34-39 place: New York publication: 2025 International Workshop on Impedance Spectroscopy (IWIS) publication_identifier: eisbn: - 979-8-3315-9322-3 isbn: - 979-8-3315-9323-0 publication_status: published publisher: IEEE status: public title: Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis type: conference_editor_article user_id: '83778' year: '2026' ... --- _id: '13712' abstract: - lang: eng text: Biopharmaceutical quality in upstream mammalian cell culture has historically relied on Quality-by-Test (QbT) paradigm, where fixed processes are verified by end-point assays despite limited process observability and substantial biological variability. This chapter discusses how Process Analytical Technology (PAT), aligned with the Quality-by-Design (QbD) framework, enables measurement-driven process understanding and timely control by linking the trajectories of critical process parameters (CPPs) to critical quality attributes (CQAs). We review fit-for-purpose at-line, on-line, and in-line analytical technologies used in mammalian cell culture and summarize their roles across the process development and manufacturing lifecycle. Applications include multivariate process characterization, state-based monitoring and control, and trajectory-based process supervision. Finally, we outline future directions toward IIoT-enabled connectivity, soft sensors, and integrated multi-sensor PAT platforms, which are expected to support adaptive control strategies, digital twins, and ultimately autonomous biomanufacturing. author: - first_name: Cheol-Hwan full_name: Park, Cheol-Hwan last_name: Park - first_name: Yunjoo full_name: Jeon, Yunjoo last_name: Jeon - first_name: Selina full_name: Uhlendorff, Selina id: '85335' last_name: Uhlendorff - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 - first_name: Dong-Yup full_name: Lee, Dong-Yup last_name: Lee citation: ama: 'Park CH, Jeon Y, Uhlendorff S, Pein-Hackelbusch M, Lee DY. Process Analytical Technology in Upstream Mammalian Cell Cultures. In: Roitberg BD, ed. Reference Module in Life Sciences. Elsevier; 2026. doi:10.1016/b978-0-443-24738-5.00086-0' apa: Park, C.-H., Jeon, Y., Uhlendorff, S., Pein-Hackelbusch, M., & Lee, D.-Y. (2026). Process Analytical Technology in Upstream Mammalian Cell Cultures. In B. D. Roitberg (Ed.), Reference Module in Life Sciences. Elsevier. https://doi.org/10.1016/b978-0-443-24738-5.00086-0 bjps: 'Park C-H et al. (2026) Process Analytical Technology in Upstream Mammalian Cell Cultures. In Roitberg BD (ed.), Reference Module in Life Sciences. [Erscheinungsort nicht ermittelbar]: Elsevier.' chicago: 'Park, Cheol-Hwan, Yunjoo Jeon, Selina Uhlendorff, Miriam Pein-Hackelbusch, and Dong-Yup Lee. “Process Analytical Technology in Upstream Mammalian Cell Cultures.” In Reference Module in Life Sciences, edited by Bernard D. Roitberg. [Erscheinungsort nicht ermittelbar]: Elsevier, 2026. https://doi.org/10.1016/b978-0-443-24738-5.00086-0.' chicago-de: 'Park, Cheol-Hwan, Yunjoo Jeon, Selina Uhlendorff, Miriam Pein-Hackelbusch und Dong-Yup Lee. 2026. Process Analytical Technology in Upstream Mammalian Cell Cultures. In: Reference Module in Life Sciences, hg. von Bernard D. Roitberg. [Erscheinungsort nicht ermittelbar]: Elsevier. doi:10.1016/b978-0-443-24738-5.00086-0, .' din1505-2-1: 'Park, Cheol-Hwan ; Jeon, Yunjoo ; Uhlendorff, Selina ; Pein-Hackelbusch, Miriam ; Lee, Dong-Yup: Process Analytical Technology in Upstream Mammalian Cell Cultures. In: Roitberg, B. D. (Hrsg.): Reference Module in Life Sciences. [Erscheinungsort nicht ermittelbar] : Elsevier, 2026' havard: 'C.-H. Park, Y. Jeon, S. Uhlendorff, M. Pein-Hackelbusch, D.-Y. Lee, Process Analytical Technology in Upstream Mammalian Cell Cultures, in: B.D. Roitberg (Ed.), Reference Module in Life Sciences, Elsevier, [Erscheinungsort nicht ermittelbar], 2026.' ieee: 'C.-H. Park, Y. Jeon, S. Uhlendorff, M. Pein-Hackelbusch, and D.-Y. Lee, “Process Analytical Technology in Upstream Mammalian Cell Cultures,” in Reference Module in Life Sciences, B. D. Roitberg, Ed. [Erscheinungsort nicht ermittelbar]: Elsevier, 2026. doi: 10.1016/b978-0-443-24738-5.00086-0.' mla: Park, Cheol-Hwan, et al. “Process Analytical Technology in Upstream Mammalian Cell Cultures.” Reference Module in Life Sciences, edited by Bernard D. Roitberg, Elsevier, 2026, https://doi.org/10.1016/b978-0-443-24738-5.00086-0. short: 'C.-H. Park, Y. Jeon, S. Uhlendorff, M. Pein-Hackelbusch, D.-Y. Lee, in: B.D. Roitberg (Ed.), Reference Module in Life Sciences, Elsevier, [Erscheinungsort nicht ermittelbar], 2026.' ufg: 'Park, Cheol-Hwan u. a.: Process Analytical Technology in Upstream Mammalian Cell Cultures, in: Roitberg, Bernard D. (Hg.): Reference Module in Life Sciences, [Erscheinungsort nicht ermittelbar] 2026.' van: 'Park CH, Jeon Y, Uhlendorff S, Pein-Hackelbusch M, Lee DY. Process Analytical Technology in Upstream Mammalian Cell Cultures. In: Roitberg BD, editor. Reference Module in Life Sciences. [Erscheinungsort nicht ermittelbar]: Elsevier; 2026.' date_created: 2026-04-28T07:11:46Z date_updated: 2026-04-29T11:16:34Z department: - _id: DEP4028 doi: 10.1016/b978-0-443-24738-5.00086-0 editor: - first_name: 'Bernard D. ' full_name: 'Roitberg, Bernard D. ' last_name: Roitberg language: - iso: eng place: '[Erscheinungsort nicht ermittelbar]' publication: Reference Module in Life Sciences publication_identifier: eisbn: - 978-0-12-809633-8 publication_status: published publisher: Elsevier status: public title: Process Analytical Technology in Upstream Mammalian Cell Cultures type: book_chapter user_id: '83781' year: '2026' ... --- _id: '13101' abstract: - lang: eng text: "Introduction: In-line sensors, which are crucial for real-time (bio-) process monitoring, can suffer from anomalies. These signal spikes and shifts compromise process control. Due to the dynamic and non-stationary nature of bioprocess signals, addressing these issues requires specialized preprocessing. However, existing anomaly detection methods often fail for real-time applications.\r\n\r\nMethods: This study addresses a common yet critical issue: developing a robust and easy-to-implement algorithm for real-time anomaly detection and removal for in-line permittivity sensor measurement. Recombinant Pichia pastoris cultivations served as a case study. Trivial approaches, such as moving average filtering, do not adequately capture the complexity of the problem. However, our method provides a structured solution through three consecutive steps: 1) Signal preprocessing to reduce noise and eliminate context dependency; 2) Anomaly detection using threshold-based identification; 3) Validation and removal of identified anomalies.\r\n\r\nResults and discussion: We demonstrate that our approach effectively detects and removes anomalies by compensating signal shift value, while remaining computationally efficient and practical for real-time use. It achieves an F1-score of 0.79 with a static threshold of 1.06 pF/cm and a double rolling aggregate transformer using window sizes w1 = 1 and w2 = 15. This flexible and scalable algorithm has the potential to bridge a crucial gap in process real-time analytics and control." article_number: '1609369' article_type: original author: - first_name: Emils full_name: Bolmanis, Emils last_name: Bolmanis - first_name: Selina full_name: Uhlendorff, Selina id: '85335' last_name: Uhlendorff - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 - first_name: Vytautas full_name: Galvanauskas, Vytautas last_name: Galvanauskas - first_name: Oskars full_name: Grigs, Oskars last_name: Grigs citation: ama: Bolmanis E, Uhlendorff S, Pein-Hackelbusch M, Galvanauskas V, Grigs O. Anomaly detection and removal strategies for in-line permittivity sensor signal used in bioprocesses. Frontiers in Bioengineering and Biotechnology. 2025;13. doi:10.3389/fbioe.2025.1609369 apa: Bolmanis, E., Uhlendorff, S., Pein-Hackelbusch, M., Galvanauskas, V., & Grigs, O. (2025). Anomaly detection and removal strategies for in-line permittivity sensor signal used in bioprocesses. Frontiers in Bioengineering and Biotechnology, 13, Article 1609369. https://doi.org/10.3389/fbioe.2025.1609369 bjps: Bolmanis E et al. (2025) Anomaly Detection and Removal Strategies for In-Line Permittivity Sensor Signal Used in Bioprocesses. Frontiers in Bioengineering and Biotechnology 13. chicago: Bolmanis, Emils, Selina Uhlendorff, Miriam Pein-Hackelbusch, Vytautas Galvanauskas, and Oskars Grigs. “Anomaly Detection and Removal Strategies for In-Line Permittivity Sensor Signal Used in Bioprocesses.” Frontiers in Bioengineering and Biotechnology 13 (2025). https://doi.org/10.3389/fbioe.2025.1609369. chicago-de: Bolmanis, Emils, Selina Uhlendorff, Miriam Pein-Hackelbusch, Vytautas Galvanauskas und Oskars Grigs. 2025. Anomaly detection and removal strategies for in-line permittivity sensor signal used in bioprocesses. Frontiers in Bioengineering and Biotechnology 13. doi:10.3389/fbioe.2025.1609369, . din1505-2-1: 'Bolmanis, Emils ; Uhlendorff, Selina ; Pein-Hackelbusch, Miriam ; Galvanauskas, Vytautas ; Grigs, Oskars: Anomaly detection and removal strategies for in-line permittivity sensor signal used in bioprocesses. In: Frontiers in Bioengineering and Biotechnology Bd. 13. Lausanne, Frontiers Media SA (2025)' havard: E. Bolmanis, S. Uhlendorff, M. Pein-Hackelbusch, V. Galvanauskas, O. Grigs, Anomaly detection and removal strategies for in-line permittivity sensor signal used in bioprocesses, Frontiers in Bioengineering and Biotechnology. 13 (2025). ieee: 'E. Bolmanis, S. Uhlendorff, M. Pein-Hackelbusch, V. Galvanauskas, and O. Grigs, “Anomaly detection and removal strategies for in-line permittivity sensor signal used in bioprocesses,” Frontiers in Bioengineering and Biotechnology, vol. 13, Art. no. 1609369, 2025, doi: 10.3389/fbioe.2025.1609369.' mla: Bolmanis, Emils, et al. “Anomaly Detection and Removal Strategies for In-Line Permittivity Sensor Signal Used in Bioprocesses.” Frontiers in Bioengineering and Biotechnology, vol. 13, 1609369, 2025, https://doi.org/10.3389/fbioe.2025.1609369. short: E. Bolmanis, S. Uhlendorff, M. Pein-Hackelbusch, V. Galvanauskas, O. Grigs, Frontiers in Bioengineering and Biotechnology 13 (2025). ufg: 'Bolmanis, Emils u. a.: Anomaly detection and removal strategies for in-line permittivity sensor signal used in bioprocesses, in: Frontiers in Bioengineering and Biotechnology 13 (2025).' van: Bolmanis E, Uhlendorff S, Pein-Hackelbusch M, Galvanauskas V, Grigs O. Anomaly detection and removal strategies for in-line permittivity sensor signal used in bioprocesses. Frontiers in Bioengineering and Biotechnology. 2025;13. date_created: 2025-07-31T09:23:31Z date_updated: 2025-10-10T07:46:08Z ddc: - '570' department: - _id: DEP4028 - _id: DEP4000 doi: 10.3389/fbioe.2025.1609369 file: - access_level: closed content_type: application/pdf creator: f6x-0e0 date_created: 2025-07-31T09:24:49Z date_updated: 2025-07-31T11:35:18Z file_id: '13102' file_name: fbioe-1-1609369.pdf file_size: 2935650 relation: main_file file_date_updated: 2025-07-31T11:35:18Z has_accepted_license: '1' intvolume: ' 13' keyword: - in-situ - permittivity - dielectric spectroscopy - signal preprocessing - dynamic threshold - static threshold - anomaly validation - Pichia pastoris language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.3389/fbioe.2025.1609369 oa: '1' place: Lausanne publication: Frontiers in Bioengineering and Biotechnology publication_identifier: eissn: - 2296-4185 publication_status: published publisher: Frontiers Media SA quality_controlled: '1' status: public title: Anomaly detection and removal strategies for in-line permittivity sensor signal used in bioprocesses type: scientific_journal_article user_id: '64952' volume: 13 year: '2025' ... --- _id: '13122' author: - first_name: Selina full_name: Uhlendorff, Selina last_name: Uhlendorff - first_name: Emils full_name: Bolmanis, Emils last_name: Bolmanis - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 - first_name: Vytautas full_name: Galvanauskas, Vytautas last_name: Galvanauskas - first_name: Oskars full_name: Grigs, Oskars last_name: Grigs citation: ama: Uhlendorff S, Bolmanis E, Pein-Hackelbusch M, Galvanauskas V, Grigs O. Analysis of Anomaly Detection Techniques for In-Line Permittivity Sensors in Bioprocesses.; 2025. apa: Uhlendorff, S., Bolmanis, E., Pein-Hackelbusch, M., Galvanauskas, V., & Grigs, O. (2025). Analysis of Anomaly Detection Techniques for In-line Permittivity Sensors in Bioprocesses. 15th European Congress of Chemical Engineering (ECCE) &  8th European Congress of Applied Biotechnology (ECAB) &  3rd Iberoamerican Congress on Chemical Engineering (CIBIQ), Lissabon. bjps: Uhlendorff S et al. (2025) Analysis of Anomaly Detection Techniques for In-Line Permittivity Sensors in Bioprocesses. . chicago: Uhlendorff, Selina, Emils Bolmanis, Miriam Pein-Hackelbusch, Vytautas Galvanauskas, and Oskars Grigs. Analysis of Anomaly Detection Techniques for In-Line Permittivity Sensors in Bioprocesses, 2025. chicago-de: Uhlendorff, Selina, Emils Bolmanis, Miriam Pein-Hackelbusch, Vytautas Galvanauskas und Oskars Grigs. 2025. Analysis of Anomaly Detection Techniques for In-line Permittivity Sensors in Bioprocesses. din1505-2-1: 'Uhlendorff, Selina ; Bolmanis, Emils ; Pein-Hackelbusch, Miriam ; Galvanauskas, Vytautas ; Grigs, Oskars: Analysis of Anomaly Detection Techniques for In-line Permittivity Sensors in Bioprocesses, 2025' havard: S. Uhlendorff, E. Bolmanis, M. Pein-Hackelbusch, V. Galvanauskas, O. Grigs, Analysis of Anomaly Detection Techniques for In-line Permittivity Sensors in Bioprocesses, 2025. ieee: S. Uhlendorff, E. Bolmanis, M. Pein-Hackelbusch, V. Galvanauskas, and O. Grigs, Analysis of Anomaly Detection Techniques for In-line Permittivity Sensors in Bioprocesses. 2025. mla: Uhlendorff, Selina, et al. Analysis of Anomaly Detection Techniques for In-Line Permittivity Sensors in Bioprocesses. 2025. short: S. Uhlendorff, E. Bolmanis, M. Pein-Hackelbusch, V. Galvanauskas, O. Grigs, Analysis of Anomaly Detection Techniques for In-Line Permittivity Sensors in Bioprocesses, 2025. ufg: 'Uhlendorff, Selina u. a.: Analysis of Anomaly Detection Techniques for In-line Permittivity Sensors in Bioprocesses, o. O. 2025.' van: Uhlendorff S, Bolmanis E, Pein-Hackelbusch M, Galvanauskas V, Grigs O. Analysis of Anomaly Detection Techniques for In-line Permittivity Sensors in Bioprocesses. 2025. conference: end_date: 2025-09-10 location: Lissabon name: 15th European Congress of Chemical Engineering (ECCE) & 8th European Congress of Applied Biotechnology (ECAB) & 3rd Iberoamerican Congress on Chemical Engineering (CIBIQ) start_date: 2025-09-08 date_created: 2025-08-12T08:01:56Z date_updated: 2025-10-09T07:39:46Z ddc: - '570' department: - _id: DEP4000 has_accepted_license: '1' language: - iso: eng publication_status: published status: public title: Analysis of Anomaly Detection Techniques for In-line Permittivity Sensors in Bioprocesses type: conference_poster user_id: '83781' year: '2025' ... --- _id: '13223' author: - first_name: Selina full_name: Uhlendorff, Selina id: '68713' last_name: Uhlendorff orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Tatsiana full_name: Burankova, Tatsiana last_name: Burankova - first_name: Katharina full_name: Dahlmann, Katharina last_name: Dahlmann - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Uhlendorff S, Burankova T, Dahlmann K, Frahm B, Pein-Hackelbusch M. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis.; 2025. apa: Uhlendorff, S., Burankova, T., Dahlmann, K., Frahm, B., & Pein-Hackelbusch, M. (2025). Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. 18th International Workshop on Impedance Spectroscopy, Chemnitz. bjps: Uhlendorff S et al. (2025) Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. . chicago: Uhlendorff, Selina, Tatsiana Burankova, Katharina Dahlmann, Björn Frahm, and Miriam Pein-Hackelbusch. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, 2025. chicago-de: Uhlendorff, Selina, Tatsiana Burankova, Katharina Dahlmann, Björn Frahm und Miriam Pein-Hackelbusch. 2025. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. din1505-2-1: 'Uhlendorff, Selina ; Burankova, Tatsiana ; Dahlmann, Katharina ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, 2025' havard: S. Uhlendorff, T. Burankova, K. Dahlmann, B. Frahm, M. Pein-Hackelbusch, Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, 2025. ieee: S. Uhlendorff, T. Burankova, K. Dahlmann, B. Frahm, and M. Pein-Hackelbusch, Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. 2025. mla: Uhlendorff, Selina, et al. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. 2025. short: S. Uhlendorff, T. Burankova, K. Dahlmann, B. Frahm, M. Pein-Hackelbusch, Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, 2025. ufg: 'Uhlendorff, Selina u. a.: Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis, o. O. 2025.' van: Uhlendorff S, Burankova T, Dahlmann K, Frahm B, Pein-Hackelbusch M. Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis. 2025. conference: end_date: 2025-09-26 location: Chemnitz name: 18th International Workshop on Impedance Spectroscopy start_date: 2025-09-23 date_created: 2025-09-29T08:37:10Z date_updated: 2026-03-27T16:51:16Z department: - _id: DEP4028 - _id: DEP4021 language: - iso: eng publication_status: published related_material: link: - relation: confirmation url: https://www.tu-chemnitz.de/etit/messtech/iwis/program.php status: public title: Application Constraints of Linear Multivariate Regression Models for Dielectric Spectroscopy in Inline Bioreactor Viable Cell Analysis type: conference_poster user_id: '45666' year: '2025' ... --- _id: '13225' abstract: - lang: eng text: In recent years, there has been an increasing awareness of the importance of incorporating diversity into research projects, focusing on both how they are conducted and their content. Funding organizations have started to require that research applicants pay attention to inclusion and diversity by considering gender dimensions and other diversity factors in their project plans and ensuring gender equality during execution. Based on an extensive literature research and expert discussions on how to develop and implement diversity strategies in large collaborative research projects, we argue that there is a lack of practical advice in existing literature. Drawing from our own experiences in conceptualizing and implementing a Diversity Program across four universities in Germany, we propose a framework for effectively integrating diversity into collaborative research initiatives across various academic fields. article_number: e70040 author: - first_name: Mariya full_name: Lorke, Mariya last_name: Lorke - first_name: Rena full_name: Amelung, Rena last_name: Amelung - first_name: Peter full_name: Kuchling, Peter last_name: Kuchling - first_name: Benjamin full_name: Paaßen, Benjamin last_name: Paaßen - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 - first_name: Franziska full_name: Schloots, Franziska last_name: Schloots - first_name: Klara full_name: Schulz, Klara last_name: Schulz - first_name: Annette full_name: Nauerth, Annette last_name: Nauerth citation: ama: 'Lorke M, Amelung R, Kuchling P, et al. Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany. Diversity & Inclusion Research. 2025;2(4). doi:10.1002/dvr2.70040' apa: 'Lorke, M., Amelung, R., Kuchling, P., Paaßen, B., Pein-Hackelbusch, M., Schloots, F., Schulz, K., & Nauerth, A. (2025). Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany. Diversity & Inclusion Research, 2(4), Article e70040. https://doi.org/10.1002/dvr2.70040' bjps: 'Lorke M et al. (2025) Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany. Diversity & Inclusion Research 2.' chicago: 'Lorke, Mariya, Rena Amelung, Peter Kuchling, Benjamin Paaßen, Miriam Pein-Hackelbusch, Franziska Schloots, Klara Schulz, and Annette Nauerth. “Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany.” Diversity & Inclusion Research 2, no. 4 (2025). https://doi.org/10.1002/dvr2.70040.' chicago-de: 'Lorke, Mariya, Rena Amelung, Peter Kuchling, Benjamin Paaßen, Miriam Pein-Hackelbusch, Franziska Schloots, Klara Schulz und Annette Nauerth. 2025. Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany. Diversity & Inclusion Research 2, Nr. 4. doi:10.1002/dvr2.70040, .' din1505-2-1: 'Lorke, Mariya ; Amelung, Rena ; Kuchling, Peter ; Paaßen, Benjamin ; Pein-Hackelbusch, Miriam ; Schloots, Franziska ; Schulz, Klara ; Nauerth, Annette: Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany. In: Diversity & Inclusion Research Bd. 2. [Hoboken, New Jersey], Wiley (2025), Nr. 4' havard: 'M. Lorke, R. Amelung, P. Kuchling, B. Paaßen, M. Pein-Hackelbusch, F. Schloots, K. Schulz, A. Nauerth, Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany, Diversity & Inclusion Research. 2 (2025).' ieee: 'M. Lorke et al., “Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany,” Diversity & Inclusion Research, vol. 2, no. 4, Art. no. e70040, 2025, doi: 10.1002/dvr2.70040.' mla: 'Lorke, Mariya, et al. “Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany.” Diversity & Inclusion Research, vol. 2, no. 4, e70040, 2025, https://doi.org/10.1002/dvr2.70040.' short: M. Lorke, R. Amelung, P. Kuchling, B. Paaßen, M. Pein-Hackelbusch, F. Schloots, K. Schulz, A. Nauerth, Diversity & Inclusion Research 2 (2025). ufg: 'Lorke, Mariya u. a.: Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany, in: Diversity & Inclusion Research 2 (2025), H. 4.' van: 'Lorke M, Amelung R, Kuchling P, Paaßen B, Pein-Hackelbusch M, Schloots F, et al. Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany. Diversity & Inclusion Research. 2025;2(4).' date_created: 2025-09-29T10:18:05Z date_updated: 2025-10-10T07:44:33Z department: - _id: DEP4028 doi: 10.1002/dvr2.70040 intvolume: ' 2' issue: '4' keyword: - collaborative research projects - diversity strategy - gender equality language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1002/dvr2.70040 oa: '1' place: '[Hoboken, New Jersey]' publication: Diversity & Inclusion Research publication_identifier: eissn: - 2835-236X publication_status: published publisher: Wiley quality_controlled: '1' status: public title: 'Development and Implementation of Diversity Programs in Large Collaborative Research Projects: An Example From Germany' type: scientific_journal_article user_id: '64952' volume: 2 year: '2025' ... --- _id: '13246' abstract: - lang: eng text: Although electronic nose technology has been studied for years, drift effects remain one of the major challenges. While ongoing research focuses on effective correction methods, the evaluation of these methods requires reliable and well-documented datasets. However, only a few drift datasets are available, some of which lack sufficient experimental detail or are outdated. This motivated us to introduce a new long-term drift dataset. It has been collected over 12 months using a commercial electronic nose, which is based on 62-metal oxide sensors. The measurements were conducted under controlled experimental conditions with three analytes (diacetyl, 2-phenylethanol, and ethanol) in different concentrations. The dataset consists of 700 time-series recordings, for which we provide both the raw data and a set of pre-extracted features. The data can support the development, evaluation, and comparison of methods for feature extraction and selection, as well as drift detection and compensation. By providing a comprehensive, well-documented dataset, we aim to advance research on sensor drift in electronic nose systems. article_number: '1628' author: - first_name: Julius full_name: Wörner, Julius id: '79011' last_name: Wörner - first_name: Jonas full_name: Eimler, Jonas id: '87971' last_name: Eimler - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: 'Wörner J, Eimler J, Pein-Hackelbusch M. Long-term drift behavior in metal oxide gas sensor arrays: a one-year dataset from an electronic nose. Scientific Data. 2025;12. doi:10.1038/s41597-025-05993-8' apa: 'Wörner, J., Eimler, J., & Pein-Hackelbusch, M. (2025). Long-term drift behavior in metal oxide gas sensor arrays: a one-year dataset from an electronic nose. Scientific Data, 12, Article 1628. https://doi.org/10.1038/s41597-025-05993-8' bjps: 'Wörner J, Eimler J and Pein-Hackelbusch M (2025) Long-Term Drift Behavior in Metal Oxide Gas Sensor Arrays: A One-Year Dataset from an Electronic Nose. Scientific Data 12.' chicago: 'Wörner, Julius, Jonas Eimler, and Miriam Pein-Hackelbusch. “Long-Term Drift Behavior in Metal Oxide Gas Sensor Arrays: A One-Year Dataset from an Electronic Nose.” Scientific Data 12 (2025). https://doi.org/10.1038/s41597-025-05993-8.' chicago-de: 'Wörner, Julius, Jonas Eimler und Miriam Pein-Hackelbusch. 2025. Long-term drift behavior in metal oxide gas sensor arrays: a one-year dataset from an electronic nose. Scientific Data 12. doi:10.1038/s41597-025-05993-8, .' din1505-2-1: 'Wörner, Julius ; Eimler, Jonas ; Pein-Hackelbusch, Miriam: Long-term drift behavior in metal oxide gas sensor arrays: a one-year dataset from an electronic nose. In: Scientific Data Bd. 12. London, Nature Research (2025)' havard: 'J. Wörner, J. Eimler, M. Pein-Hackelbusch, Long-term drift behavior in metal oxide gas sensor arrays: a one-year dataset from an electronic nose, Scientific Data. 12 (2025).' ieee: 'J. Wörner, J. Eimler, and M. Pein-Hackelbusch, “Long-term drift behavior in metal oxide gas sensor arrays: a one-year dataset from an electronic nose,” Scientific Data, vol. 12, Art. no. 1628, 2025, doi: 10.1038/s41597-025-05993-8.' mla: 'Wörner, Julius, et al. “Long-Term Drift Behavior in Metal Oxide Gas Sensor Arrays: A One-Year Dataset from an Electronic Nose.” Scientific Data, vol. 12, 1628, 2025, https://doi.org/10.1038/s41597-025-05993-8.' short: J. Wörner, J. Eimler, M. Pein-Hackelbusch, Scientific Data 12 (2025). ufg: 'Wörner, Julius/Eimler, Jonas/Pein-Hackelbusch, Miriam: Long-term drift behavior in metal oxide gas sensor arrays: a one-year dataset from an electronic nose, in: Scientific Data 12 (2025).' van: 'Wörner J, Eimler J, Pein-Hackelbusch M. Long-term drift behavior in metal oxide gas sensor arrays: a one-year dataset from an electronic nose. Scientific Data. 2025;12.' date_created: 2025-10-10T06:03:22Z date_updated: 2025-10-14T08:00:07Z department: - _id: DEP4028 doi: 10.1038/s41597-025-05993-8 intvolume: ' 12' language: - iso: eng place: London publication: Scientific Data publication_identifier: eissn: - 2052-4463 publication_status: published publisher: Nature Research status: public title: 'Long-term drift behavior in metal oxide gas sensor arrays: a one-year dataset from an electronic nose' type: scientific_journal_article user_id: '83781' volume: 12 year: '2025' ... --- _id: '13315' abstract: - lang: eng text: Determining cell density and viability with (semi‐)automated methods enables rapid cell cultivation analysis. However, scientific validation is required, typically by comparing results to manual counting. To address this, we present a method to evaluate and compare two cell counting methods exemplified by a manual and a semi‐automated method (Countstar BioTech). Experiments followed validation parameters aligned with the International Council for Harmonization (ICH) Q2(R1) guideline and a dilution series design based on ISO 20391‐2:2019. Both the semi‐automated and manual methods showed comparable specificity and linearity for Chinese hamster ovary (CHO)‐K1 cells. The semi‐automated method exhibited superior repeatability for total cell density, whereas cell viability results showed no significant difference. author: - first_name: Selina full_name: Uhlendorff, Selina id: '68713' last_name: Uhlendorff orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Ulrich full_name: Odefey, Ulrich id: '74218' last_name: Odefey - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Uhlendorff S, Odefey U, Frahm B, Pein-Hackelbusch M. Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. Chemie Ingenieur Technik. 2025;98(1-2):57-68. doi:10.1002/cite.70048 apa: Uhlendorff, S., Odefey, U., Frahm, B., & Pein-Hackelbusch, M. (2025). Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. Chemie Ingenieur Technik, 98(1–2), 57–68. https://doi.org/10.1002/cite.70048 bjps: Uhlendorff S et al. (2025) Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. Chemie Ingenieur Technik 98, 57–68. chicago: 'Uhlendorff, Selina, Ulrich Odefey, Björn Frahm, and Miriam Pein-Hackelbusch. “Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture.” Chemie Ingenieur Technik 98, no. 1–2 (2025): 57–68. https://doi.org/10.1002/cite.70048.' chicago-de: 'Uhlendorff, Selina, Ulrich Odefey, Björn Frahm und Miriam Pein-Hackelbusch. 2025. Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. Chemie Ingenieur Technik 98, Nr. 1–2: 57–68. doi:10.1002/cite.70048, .' din1505-2-1: 'Uhlendorff, Selina ; Odefey, Ulrich ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. In: Chemie Ingenieur Technik Bd. 98. Weinheim, Wiley (2025), Nr. 1–2, S. 57–68' havard: S. Uhlendorff, U. Odefey, B. Frahm, M. Pein-Hackelbusch, Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture, Chemie Ingenieur Technik. 98 (2025) 57–68. ieee: 'S. Uhlendorff, U. Odefey, B. Frahm, and M. Pein-Hackelbusch, “Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture,” Chemie Ingenieur Technik, vol. 98, no. 1–2, pp. 57–68, 2025, doi: 10.1002/cite.70048.' mla: Uhlendorff, Selina, et al. “Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture.” Chemie Ingenieur Technik, vol. 98, no. 1–2, 2025, pp. 57–68, https://doi.org/10.1002/cite.70048. short: S. Uhlendorff, U. Odefey, B. Frahm, M. Pein-Hackelbusch, Chemie Ingenieur Technik 98 (2025) 57–68. ufg: 'Uhlendorff, Selina u. a.: Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture, in: Chemie Ingenieur Technik 98 (2025), H. 1–2,  S. 57–68.' van: Uhlendorff S, Odefey U, Frahm B, Pein-Hackelbusch M. Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture. Chemie Ingenieur Technik. 2025;98(1–2):57–68. date_created: 2025-12-08T07:26:52Z date_updated: 2026-03-27T17:14:42Z department: - _id: DEP4029 - _id: DEP4028 doi: 10.1002/cite.70048 intvolume: ' 98' issue: 1-2 keyword: - Cell density - Cell enumeration - Cell viability - CHO-K1 language: - iso: eng main_file_link: - open_access: '1' oa: '1' page: 57–68 place: Weinheim publication: Chemie Ingenieur Technik publication_identifier: eissn: - 1522-2640 issn: - 0009-286X publication_status: published publisher: Wiley quality_controlled: '1' status: public title: Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture type: scientific_journal_article user_id: '45666' volume: 98 year: '2025' ... --- _id: '13316' author: - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: 'Pein-Hackelbusch M. An die Hand genommen - Adhärenz bei Kindern. PTA heute : Praxiswissen für die Apotheke. 2025;39(23):38-42.' apa: 'Pein-Hackelbusch, M. (2025). An die Hand genommen - Adhärenz bei Kindern. PTA heute : Praxiswissen für die Apotheke, 39(23), 38–42.' bjps: 'Pein-Hackelbusch M (2025) An die Hand genommen - Adhärenz bei Kindern. PTA heute : Praxiswissen für die Apotheke 39, 38–42.' chicago: 'Pein-Hackelbusch, Miriam. “An die Hand genommen - Adhärenz bei Kindern.” PTA heute : Praxiswissen für die Apotheke 39, no. 23 (2025): 38–42.' chicago-de: 'Pein-Hackelbusch, Miriam. 2025. An die Hand genommen - Adhärenz bei Kindern. PTA heute : Praxiswissen für die Apotheke 39, Nr. 23: 38–42.' din1505-2-1: 'Pein-Hackelbusch, Miriam: An die Hand genommen - Adhärenz bei Kindern. In: PTA heute : Praxiswissen für die Apotheke Bd. 39. Stuttgart, Deutscher Apotheker Verlag (2025), Nr. 23, S. 38–42' havard: 'M. Pein-Hackelbusch, An die Hand genommen - Adhärenz bei Kindern, PTA heute : Praxiswissen für die Apotheke. 39 (2025) 38–42.' ieee: 'M. Pein-Hackelbusch, “An die Hand genommen - Adhärenz bei Kindern,” PTA heute : Praxiswissen für die Apotheke, vol. 39, no. 23, pp. 38–42, 2025.' mla: 'Pein-Hackelbusch, Miriam. “An die Hand genommen - Adhärenz bei Kindern.” PTA heute : Praxiswissen für die Apotheke, vol. 39, no. 23, 2025, pp. 38–42.' short: 'M. Pein-Hackelbusch, PTA heute : Praxiswissen für die Apotheke 39 (2025) 38–42.' ufg: 'Pein-Hackelbusch, Miriam: An die Hand genommen - Adhärenz bei Kindern, in: PTA heute : Praxiswissen für die Apotheke 39 (2025), H. 23,  S. 38–42.' van: 'Pein-Hackelbusch M. An die Hand genommen - Adhärenz bei Kindern. PTA heute : Praxiswissen für die Apotheke. 2025;39(23):38–42.' date_created: 2025-12-08T10:06:05Z date_updated: 2025-12-08T14:47:21Z department: - _id: DEP4028 intvolume: ' 39' issue: '23' language: - iso: ger page: 38-42 place: Stuttgart publication: 'PTA heute : Praxiswissen für die Apotheke' publication_identifier: issn: - 0302-167X publication_status: published publisher: Deutscher Apotheker Verlag status: public title: An die Hand genommen - Adhärenz bei Kindern type: industry_journal_article user_id: '83781' volume: 39 year: '2025' ... --- _id: '13329' author: - first_name: Lisa full_name: Kemper, Lisa id: '74472' last_name: Kemper - first_name: Julius full_name: Wörner, Julius id: '79011' last_name: Wörner - first_name: Jan full_name: Schneider, Jan id: '13209' last_name: Schneider orcid: 0000-0001-6401-8873 - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Kemper L, Wörner J, Schneider J, Pein-Hackelbusch M. Diacetyl Detection by Electronic Nose in Beer-Imitating Matrices.; 2025. apa: Kemper, L., Wörner, J., Schneider, J., & Pein-Hackelbusch, M. (2025). Diacetyl detection by electronic nose in beer-imitating matrices. 15th European Congress of Chemical Engineering (ECCE) & 8th European Congress of Applied Biotechnology (ECAB), Lissabon, Portugal. bjps: Kemper L et al. (2025) Diacetyl Detection by Electronic Nose in Beer-Imitating Matrices. . chicago: Kemper, Lisa, Julius Wörner, Jan Schneider, and Miriam Pein-Hackelbusch. Diacetyl Detection by Electronic Nose in Beer-Imitating Matrices, 2025. chicago-de: Kemper, Lisa, Julius Wörner, Jan Schneider und Miriam Pein-Hackelbusch. 2025. Diacetyl detection by electronic nose in beer-imitating matrices. din1505-2-1: 'Kemper, Lisa ; Wörner, Julius ; Schneider, Jan ; Pein-Hackelbusch, Miriam: Diacetyl detection by electronic nose in beer-imitating matrices, 2025' havard: L. Kemper, J. Wörner, J. Schneider, M. Pein-Hackelbusch, Diacetyl detection by electronic nose in beer-imitating matrices, 2025. ieee: L. Kemper, J. Wörner, J. Schneider, and M. Pein-Hackelbusch, Diacetyl detection by electronic nose in beer-imitating matrices. 2025. mla: Kemper, Lisa, et al. Diacetyl Detection by Electronic Nose in Beer-Imitating Matrices. 2025. short: L. Kemper, J. Wörner, J. Schneider, M. Pein-Hackelbusch, Diacetyl Detection by Electronic Nose in Beer-Imitating Matrices, 2025. ufg: 'Kemper, Lisa u. a.: Diacetyl detection by electronic nose in beer-imitating matrices, o. O. 2025.' van: Kemper L, Wörner J, Schneider J, Pein-Hackelbusch M. Diacetyl detection by electronic nose in beer-imitating matrices. 2025. conference: end_date: 2025-09-10 location: Lissabon, Portugal name: 15th European Congress of Chemical Engineering (ECCE) & 8th European Congress of Applied Biotechnology (ECAB) start_date: 2025-09-08 date_created: 2026-01-05T15:29:12Z date_updated: 2026-01-07T13:11:48Z department: - _id: DEP4028 - _id: DEP4000 language: - iso: eng publication_status: published status: public title: Diacetyl detection by electronic nose in beer-imitating matrices type: conference_poster user_id: '83781' year: '2025' ... --- _id: '12781' abstract: - lang: eng text: Roller compaction/dry granulation (RC/DG) is a key process in pharmaceutical manufacturing for improving powder flowability, density, and segregation resistance. Advanced statistical modeling was used to optimize RC/DG process parameters and subsequently binder compositions by employing process and mixture design experiments. The authors used microcrystalline cellulose (MCC), silicified MCC (SMCC), and dicalcium phosphate (DCP) as filler-binder examples in RC/DG experiments. Granule and tablet properties, including flowability, bulk and tapped densities, as well as resistance to crushing, were analyzed using compendial methods. The process design experiments confirmed that RC/DG reduces manufacturability compared to direct compression. Optimal processing conditions, balancing sufficient tablet strengths and granule formation, were identified to be between 20 (SCF * ϑ) [kN/cm] and ∼ 60 (SCF * ϑ) [kN/cm]. Thereby (ϑ) is defined as the screw-to-roll speed ratio and (SFC) as the specific compaction force. Mixture design experiments revealed optimal mixtures balancing SMCC, MCC, and DCP to achieve desired properties like low angle of repose, high bulk density, and strong tablets. These findings provide guidance for selecting formulations and process parameters in RC/DG applications. The derived ‘SCF * ϑ’- factor was found to effectively describe the granulation intensity. A superimposed mixture design model based on precise target values of the parameters bulk density, flow properties, and breaking force allowed identification of the best formulation. article_number: '100331' author: - first_name: Niclas full_name: Märkle, Niclas id: '74898' last_name: Märkle - first_name: Gernot full_name: Warnke, Gernot last_name: Warnke - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: 'Märkle N, Warnke G, Pein-Hackelbusch M. An iterative process and mixture design approach for dry granulated ternary blends of filler-binders. International Journal of Pharmaceutics: X. 2025;9. doi:10.1016/j.ijpx.2025.100331' apa: 'Märkle, N., Warnke, G., & Pein-Hackelbusch, M. (2025). An iterative process and mixture design approach for dry granulated ternary blends of filler-binders. International Journal of Pharmaceutics: X, 9, Article 100331. https://doi.org/10.1016/j.ijpx.2025.100331' bjps: 'Märkle N, Warnke G and Pein-Hackelbusch M (2025) An Iterative Process and Mixture Design Approach for Dry Granulated Ternary Blends of Filler-Binders. International Journal of Pharmaceutics: X 9.' chicago: 'Märkle, Niclas, Gernot Warnke, and Miriam Pein-Hackelbusch. “An Iterative Process and Mixture Design Approach for Dry Granulated Ternary Blends of Filler-Binders.” International Journal of Pharmaceutics: X 9 (2025). https://doi.org/10.1016/j.ijpx.2025.100331.' chicago-de: 'Märkle, Niclas, Gernot Warnke und Miriam Pein-Hackelbusch. 2025. An iterative process and mixture design approach for dry granulated ternary blends of filler-binders. International Journal of Pharmaceutics: X 9. doi:10.1016/j.ijpx.2025.100331, .' din1505-2-1: 'Märkle, Niclas ; Warnke, Gernot ; Pein-Hackelbusch, Miriam: An iterative process and mixture design approach for dry granulated ternary blends of filler-binders. In: International Journal of Pharmaceutics: X Bd. 9. Amsterdam, Elsevier BV (2025)' havard: 'N. Märkle, G. Warnke, M. Pein-Hackelbusch, An iterative process and mixture design approach for dry granulated ternary blends of filler-binders, International Journal of Pharmaceutics: X. 9 (2025).' ieee: 'N. Märkle, G. Warnke, and M. Pein-Hackelbusch, “An iterative process and mixture design approach for dry granulated ternary blends of filler-binders,” International Journal of Pharmaceutics: X, vol. 9, Art. no. 100331, 2025, doi: 10.1016/j.ijpx.2025.100331.' mla: 'Märkle, Niclas, et al. “An Iterative Process and Mixture Design Approach for Dry Granulated Ternary Blends of Filler-Binders.” International Journal of Pharmaceutics: X, vol. 9, 100331, 2025, https://doi.org/10.1016/j.ijpx.2025.100331.' short: 'N. Märkle, G. Warnke, M. Pein-Hackelbusch, International Journal of Pharmaceutics: X 9 (2025).' ufg: 'Märkle, Niclas/Warnke, Gernot/Pein-Hackelbusch, Miriam: An iterative process and mixture design approach for dry granulated ternary blends of filler-binders, in: International Journal of Pharmaceutics: X 9 (2025).' van: 'Märkle N, Warnke G, Pein-Hackelbusch M. An iterative process and mixture design approach for dry granulated ternary blends of filler-binders. International Journal of Pharmaceutics: X. 2025;9.' date_created: 2025-04-11T08:39:07Z date_updated: 2025-05-08T08:20:23Z department: - _id: DEP4022 - _id: DEP4028 doi: 10.1016/j.ijpx.2025.100331 external_id: pmid: - '40242454 ' intvolume: ' 9' keyword: - Design of experiments - Roller compaction/dry granulation - RC/DG - Dicalcium phosphate - Microcrystalline cellulose - Silicified microcrystalline cellulose language: - iso: eng main_file_link: - open_access: '1' url: https://www.sciencedirect.com/science/article/pii/S2590156725000167 oa: '1' place: Amsterdam pmid: '1' publication: 'International Journal of Pharmaceutics: X' publication_identifier: eissn: - 2590-1567 issn: - 1873-3476 publication_status: published publisher: Elsevier BV quality_controlled: '1' status: public title: An iterative process and mixture design approach for dry granulated ternary blends of filler-binders type: scientific_journal_article user_id: '83781' volume: 9 year: '2025' ... --- _id: '11492' abstract: - lang: eng text: In this review, we aim to highlight the advantages, challenges, and limitations of electronic tongues (e-tongues) in pharmaceutical drug development. The authors, therefore, critically evaluated the performance of e-tongues regarding their qualification to assess peroral formulations containing bitter active pharmaceutical ingredients. A literature search using the keywords ‘electronic’, ‘tongue’, ‘bitter’, and ‘drug’ in a Web of Science search was therefore initially conducted. Reviewing the publications of the past decade, and further literature where necessary, allowed the authors to discuss whether and how e-tongues perform as expected and whether they have the potential to become a standard tool in drug development. Specifically highlighted are the expectations an e-tongue should meet. Further, a brief insight into the technologies of the utilized e-tongues is given. Reliable protocols were found that enable (i) the qualified performance of e-tongue instruments from an analytical perspective, (ii) proper taste-masking assessments, and (iii) under certain circumstances, the evaluation of bitterness. article_type: review author: - first_name: Denise full_name: Steiner, Denise last_name: Steiner - first_name: Alexander full_name: Meyer, Alexander id: '58585' last_name: Meyer - first_name: Isabell full_name: Immohr, Isabell last_name: Immohr - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Steiner D, Meyer A, Immohr I, Pein-Hackelbusch M. Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. Pharmaceutics. 2024;16(5). doi:10.3390/pharmaceutics16050658 apa: Steiner, D., Meyer, A., Immohr, I., & Pein-Hackelbusch, M. (2024). Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. Pharmaceutics, 16(5). https://doi.org/10.3390/pharmaceutics16050658 bjps: Steiner D et al. (2024) Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. Pharmaceutics 16. chicago: Steiner, Denise, Alexander Meyer, Isabell Immohr, and Miriam Pein-Hackelbusch. “Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients.” Pharmaceutics 16, no. 5 (2024). https://doi.org/10.3390/pharmaceutics16050658. chicago-de: Steiner, Denise, Alexander Meyer, Isabell Immohr und Miriam Pein-Hackelbusch. 2024. Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. Pharmaceutics 16, Nr. 5. doi:10.3390/pharmaceutics16050658, . din1505-2-1: 'Steiner, Denise ; Meyer, Alexander ; Immohr, Isabell ; Pein-Hackelbusch, Miriam: Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. In: Pharmaceutics Bd. 16. Basel, MDPI (2024), Nr. 5' havard: D. Steiner, A. Meyer, I. Immohr, M. Pein-Hackelbusch, Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients, Pharmaceutics. 16 (2024). ieee: 'D. Steiner, A. Meyer, I. Immohr, and M. Pein-Hackelbusch, “Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients,” Pharmaceutics, vol. 16, no. 5, 2024, doi: 10.3390/pharmaceutics16050658.' mla: Steiner, Denise, et al. “Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients.” Pharmaceutics, vol. 16, no. 5, 2024, https://doi.org/10.3390/pharmaceutics16050658. short: D. Steiner, A. Meyer, I. Immohr, M. Pein-Hackelbusch, Pharmaceutics 16 (2024). ufg: 'Steiner, Denise u. a.: Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients, in: Pharmaceutics 16 (2024), H. 5.' van: Steiner D, Meyer A, Immohr I, Pein-Hackelbusch M. Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients. Pharmaceutics. 2024;16(5). date_created: 2024-05-29T10:06:47Z date_updated: 2025-06-24T09:07:27Z department: - _id: DEP4028 doi: 10.3390/pharmaceutics16050658 external_id: isi: - '001231317000001' pmid: - '38794320' intvolume: ' 16' isi: '1' issue: '5' keyword: - e-tongues - performance - qualification - taste masking - bitterness - dosage forms - drug formulations language: - iso: eng main_file_link: - open_access: '1' url: https://www.mdpi.com/1999-4923/16/5/658 oa: '1' place: Basel pmid: '1' publication: Pharmaceutics publication_identifier: eissn: - '1999-4923 ' publication_status: published publisher: MDPI quality_controlled: '1' status: public title: Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients type: scientific_journal_article user_id: '83778' volume: 16 year: '2024' ... --- _id: '11493' abstract: - lang: ger text: Eine in 2023 in Irland durchgeführte Studie kommt zu dem Ergebnis, dass unter anderem ein schlechter Geschmack von Antibiotika-Zubereitungen zu einer schlechten Compliance bei Kindern führt. Aber wie sehen die Geschmacksmaskierungs­strategien von in Deutschland erhältlichen Antibiotika-­Trockensaftformulierungen aus und zu welchem Zeitpunkt der Arzneimittelentwicklung kann das Thema Geschmack überhaupt adressiert werden? article_type: review author: - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: 'Pein-Hackelbusch M. Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften. Deutsche Apotheker Zeitung. 2024;164(14):38-42.' apa: 'Pein-Hackelbusch, M. (2024). Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften. Deutsche Apotheker Zeitung, 164(14), 38–42.' bjps: 'Pein-Hackelbusch M (2024) Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften. Deutsche Apotheker Zeitung 164, 38–42.' chicago: 'Pein-Hackelbusch, Miriam. “Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften.” Deutsche Apotheker Zeitung 164, no. 14 (2024): 38–42.' chicago-de: 'Pein-Hackelbusch, Miriam. 2024. Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften. Deutsche Apotheker Zeitung 164, Nr. 14: 38–42.' din1505-2-1: 'Pein-Hackelbusch, Miriam: Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften. In: Deutsche Apotheker Zeitung Bd. 164. Stuttgart, Deutscher Apothekerverlag (2024), Nr. 14, S. 38–42' havard: 'M. Pein-Hackelbusch, Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften, Deutsche Apotheker Zeitung. 164 (2024) 38–42.' ieee: 'M. Pein-Hackelbusch, “Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften,” Deutsche Apotheker Zeitung, vol. 164, no. 14, pp. 38–42, 2024.' mla: 'Pein-Hackelbusch, Miriam. “Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften.” Deutsche Apotheker Zeitung, vol. 164, no. 14, 2024, pp. 38–42.' short: M. Pein-Hackelbusch, Deutsche Apotheker Zeitung 164 (2024) 38–42. ufg: 'Pein-Hackelbusch, Miriam: Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften, in: Deutsche Apotheker Zeitung 164 (2024), H. 14,  S. 38–42.' van: 'Pein-Hackelbusch M. Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften. Deutsche Apotheker Zeitung. 2024;164(14):38–42.' date_created: 2024-05-29T10:11:16Z date_updated: 2024-06-03T09:41:09Z department: - _id: DEP4028 intvolume: ' 164' issue: '14' language: - iso: ger page: 38-42 place: Stuttgart publication: Deutsche Apotheker Zeitung publication_identifier: issn: - '0011-9857 ' publication_status: published publisher: Deutscher Apothekerverlag related_material: link: - relation: confirmation url: https://www.deutsche-apotheker-zeitung.de/daz-az/2024/daz-14-2024/hauptsache-suess status: public title: 'Hauptsache süß : Über die Geschmacksmaskierung in Antibiotika-Säften' type: industry_journal_article user_id: '83781' volume: 164 year: '2024' ... --- _id: '11495' abstract: - lang: eng text: 'To evaluate the suitability of an analytical instrument, essential figures of merit such as the limit of detection (LOD) and the limit of quantification (LOQ) can be employed. However, as the definitions k nown in the literature are mostly applicable to one signal per sample, estimating the LOD for substances with instruments yielding multidimensional results like electronic noses (eNoses) is still challenging. In this paper, we will compare and present different approaches to estimate the LOD for eNoses by employing commonly used multivariate data analysis and regression techniques, including principal component analysis (PCA), principal component regression (PCR), as well as partial least squares regression (PLSR). These methods could subsequently be used to assess the suitability of eNoses to help control and steer processes where volatiles are key process parameters. As a use case, we determined the LODs for key compounds involved in beer maturation, namely acetaldehyde, diacetyl, dimethyl sulfide, ethyl acetate, isobutanol, and 2-phenylethanol, and discussed the suitability of our eNose for that dertermination process. The results of the methods performed demonstrated differences of up to a factor of eight. For diacetyl, the LOD and the LOQ were sufficiently low to suggest potential for monitoring via eNose. ' article_number: '3520' article_type: original author: - first_name: Julia full_name: Kruse, Julia id: '82298' last_name: Kruse - first_name: Julius full_name: Wörner, Julius id: '79011' last_name: Wörner - first_name: Jan full_name: Schneider, Jan id: '13209' last_name: Schneider orcid: 0000-0001-6401-8873 - first_name: Helene full_name: Dörksen, Helene id: '46416' last_name: Dörksen - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Kruse J, Wörner J, Schneider J, Dörksen H, Pein-Hackelbusch M. Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses . Sensors. 2024;24(11). doi:10.3390/s24113520 apa: Kruse, J., Wörner, J., Schneider, J., Dörksen, H., & Pein-Hackelbusch, M. (2024). Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses . Sensors, 24(11), Article 3520. https://doi.org/10.3390/s24113520 bjps: Kruse J et al. (2024) Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses . Sensors 24. chicago: Kruse, Julia, Julius Wörner, Jan Schneider, Helene Dörksen, and Miriam Pein-Hackelbusch. “Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses .” Sensors 24, no. 11 (2024). https://doi.org/10.3390/s24113520. chicago-de: Kruse, Julia, Julius Wörner, Jan Schneider, Helene Dörksen und Miriam Pein-Hackelbusch. 2024. Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses . Sensors 24, Nr. 11. doi:10.3390/s24113520, . din1505-2-1: 'Kruse, Julia ; Wörner, Julius ; Schneider, Jan ; Dörksen, Helene ; Pein-Hackelbusch, Miriam: Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses . In: Sensors Bd. 24, MDPI (2024), Nr. 11' havard: J. Kruse, J. Wörner, J. Schneider, H. Dörksen, M. Pein-Hackelbusch, Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses , Sensors. 24 (2024). ieee: 'J. Kruse, J. Wörner, J. Schneider, H. Dörksen, and M. Pein-Hackelbusch, “Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses ,” Sensors, vol. 24, no. 11, Art. no. 3520, 2024, doi: 10.3390/s24113520.' mla: Kruse, Julia, et al. “Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses .” Sensors, vol. 24, no. 11, 3520, 2024, https://doi.org/10.3390/s24113520. short: J. Kruse, J. Wörner, J. Schneider, H. Dörksen, M. Pein-Hackelbusch, Sensors 24 (2024). ufg: 'Kruse, Julia u. a.: Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses , in: Sensors 24 (2024), H. 11.' van: Kruse J, Wörner J, Schneider J, Dörksen H, Pein-Hackelbusch M. Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses . Sensors. 2024;24(11). date_created: 2024-06-03T07:43:48Z date_updated: 2025-06-25T13:00:14Z department: - _id: DEP4028 doi: 10.3390/s24113520 external_id: isi: - '001245424000001' pmid: - '38894312' intvolume: ' 24' isi: '1' issue: '11' keyword: - multidimensional sensor arrays - MOS sensors - beer fermentation - process control - gas analysis - metal oxide semiconductors - intentional data analysis - chemometrics - PLSR - PCA - first-order calibration language: - iso: eng main_file_link: - open_access: '1' url: https://www.mdpi.com/1424-8220/24/11/3520 oa: '1' pmid: '1' publication: Sensors publication_identifier: issn: - '1424-8220 ' publication_status: published publisher: MDPI quality_controlled: '1' status: public title: 'Methods for Estimating the Detection and Quantification Limits of Key Substances in Beer Maturation with Electronic Noses ' type: scientific_journal_article user_id: '83781' volume: 24 year: '2024' ... --- _id: '11537' author: - first_name: Linda full_name: Katsch, Linda id: '71614' last_name: Katsch orcid: '0000-0001-6628-3929 ' - first_name: Marc full_name: Trilling-Haasler, Marc id: '81622' last_name: Trilling-Haasler orcid: 0000-0002-3685-6383 - first_name: Amir full_name: Fahmi, Amir last_name: Fahmi - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 - first_name: Jan full_name: Schneider, Jan id: '13209' last_name: Schneider orcid: 0000-0001-6401-8873 citation: ama: Katsch L, Trilling-Haasler M, Fahmi A, Pein-Hackelbusch M, Schneider J. Determination and Prediction of the Recycled Polyethylene Terephthalate Content in Preforms for the Production of Beverage Bottles.; 2024. apa: Katsch, L., Trilling-Haasler, M., Fahmi, A., Pein-Hackelbusch, M., & Schneider, J. (2024). Determination and prediction of the recycled polyethylene terephthalate content in preforms for the production of beverage bottles. 39th EBC Congress, Lille. bjps: Katsch L et al. (2024) Determination and Prediction of the Recycled Polyethylene Terephthalate Content in Preforms for the Production of Beverage Bottles. . chicago: Katsch, Linda, Marc Trilling-Haasler, Amir Fahmi, Miriam Pein-Hackelbusch, and Jan Schneider. Determination and Prediction of the Recycled Polyethylene Terephthalate Content in Preforms for the Production of Beverage Bottles, 2024. chicago-de: Katsch, Linda, Marc Trilling-Haasler, Amir Fahmi, Miriam Pein-Hackelbusch und Jan Schneider. 2024. Determination and prediction of the recycled polyethylene terephthalate content in preforms for the production of beverage bottles. din1505-2-1: 'Katsch, Linda ; Trilling-Haasler, Marc ; Fahmi, Amir ; Pein-Hackelbusch, Miriam ; Schneider, Jan: Determination and prediction of the recycled polyethylene terephthalate content in preforms for the production of beverage bottles, 2024' havard: L. Katsch, M. Trilling-Haasler, A. Fahmi, M. Pein-Hackelbusch, J. Schneider, Determination and prediction of the recycled polyethylene terephthalate content in preforms for the production of beverage bottles, 2024. ieee: L. Katsch, M. Trilling-Haasler, A. Fahmi, M. Pein-Hackelbusch, and J. Schneider, Determination and prediction of the recycled polyethylene terephthalate content in preforms for the production of beverage bottles. 2024. mla: Katsch, Linda, et al. Determination and Prediction of the Recycled Polyethylene Terephthalate Content in Preforms for the Production of Beverage Bottles. 2024. short: L. Katsch, M. Trilling-Haasler, A. Fahmi, M. Pein-Hackelbusch, J. Schneider, Determination and Prediction of the Recycled Polyethylene Terephthalate Content in Preforms for the Production of Beverage Bottles, 2024. ufg: 'Katsch, Linda u. a.: Determination and prediction of the recycled polyethylene terephthalate content in preforms for the production of beverage bottles, o. O. 2024.' van: Katsch L, Trilling-Haasler M, Fahmi A, Pein-Hackelbusch M, Schneider J. Determination and prediction of the recycled polyethylene terephthalate content in preforms for the production of beverage bottles. 2024. conference: end_date: 2024-05-30 location: Lille name: 39th EBC Congress start_date: 2024-05-26 date_created: 2024-06-18T10:28:05Z date_updated: 2025-10-17T18:30:25Z department: - _id: DEP4018 - _id: DEP4028 - _id: DEP1308 language: - iso: eng publication_status: published status: public title: Determination and prediction of the recycled polyethylene terephthalate content in preforms for the production of beverage bottles type: conference_poster user_id: '81304' year: '2024' ... --- _id: '11996' author: - first_name: Linda full_name: Katsch, Linda id: '71614' last_name: Katsch orcid: '0000-0001-6628-3929 ' - first_name: Marc full_name: Trilling-Haasler, Marc id: '81622' last_name: Trilling-Haasler orcid: 0000-0002-3685-6383 - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 - first_name: Jan full_name: Schneider, Jan id: '13209' last_name: Schneider orcid: 0000-0001-6401-8873 citation: ama: Katsch L, Trilling-Haasler M, Pein-Hackelbusch M, Schneider J. PETauthent – Authentication of PET Recyclate for Food Packaging Using Data-Intensive Sensors and Machine Learning Methods.; 2024. apa: Katsch, L., Trilling-Haasler, M., Pein-Hackelbusch, M., & Schneider, J. (2024). PETauthent – Authentication of PET recyclate for food packaging using data-intensive sensors and machine learning methods. Anuga FoodTec , Köln. bjps: Katsch L et al. (2024) PETauthent – Authentication of PET Recyclate for Food Packaging Using Data-Intensive Sensors and Machine Learning Methods. . chicago: Katsch, Linda, Marc Trilling-Haasler, Miriam Pein-Hackelbusch, and Jan Schneider. PETauthent – Authentication of PET Recyclate for Food Packaging Using Data-Intensive Sensors and Machine Learning Methods, 2024. chicago-de: Katsch, Linda, Marc Trilling-Haasler, Miriam Pein-Hackelbusch und Jan Schneider. 2024. PETauthent – Authentication of PET recyclate for food packaging using data-intensive sensors and machine learning methods. din1505-2-1: 'Katsch, Linda ; Trilling-Haasler, Marc ; Pein-Hackelbusch, Miriam ; Schneider, Jan: PETauthent – Authentication of PET recyclate for food packaging using data-intensive sensors and machine learning methods, 2024' havard: L. Katsch, M. Trilling-Haasler, M. Pein-Hackelbusch, J. Schneider, PETauthent – Authentication of PET recyclate for food packaging using data-intensive sensors and machine learning methods, 2024. ieee: L. Katsch, M. Trilling-Haasler, M. Pein-Hackelbusch, and J. Schneider, PETauthent – Authentication of PET recyclate for food packaging using data-intensive sensors and machine learning methods. 2024. mla: Katsch, Linda, et al. PETauthent – Authentication of PET Recyclate for Food Packaging Using Data-Intensive Sensors and Machine Learning Methods. 2024. short: L. Katsch, M. Trilling-Haasler, M. Pein-Hackelbusch, J. Schneider, PETauthent – Authentication of PET Recyclate for Food Packaging Using Data-Intensive Sensors and Machine Learning Methods, 2024. ufg: 'Katsch, Linda u. a.: PETauthent – Authentication of PET recyclate for food packaging using data-intensive sensors and machine learning methods, o. O. 2024.' van: Katsch L, Trilling-Haasler M, Pein-Hackelbusch M, Schneider J. PETauthent – Authentication of PET recyclate for food packaging using data-intensive sensors and machine learning methods. 2024. conference: end_date: 2024-03-22 location: Köln name: 'Anuga FoodTec ' start_date: 2024-03-19 date_created: 2024-10-15T16:50:51Z date_updated: 2025-10-17T18:29:19Z department: - _id: DEP4018 - _id: DEP4028 - _id: DEP1308 language: - iso: eng publication_status: published status: public title: PETauthent – Authentication of PET recyclate for food packaging using data-intensive sensors and machine learning methods type: conference_poster user_id: '81304' year: '2024' ... --- _id: '12013' author: - first_name: Marc full_name: Trilling-Haasler, Marc id: '81622' last_name: Trilling-Haasler orcid: 0000-0002-3685-6383 - first_name: Linda full_name: Katsch, Linda id: '71614' last_name: Katsch orcid: '0000-0001-6628-3929 ' - first_name: Amir full_name: Fahmi, Amir last_name: Fahmi - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 - first_name: Jan full_name: Schneider, Jan id: '13209' last_name: Schneider orcid: 0000-0001-6401-8873 citation: ama: Trilling-Haasler M, Katsch L, Fahmi A, Pein-Hackelbusch M, Schneider J. Der rPET Gehalt in Flaschen - eine Frage des Glaubens? .; 2024. apa: Trilling-Haasler, M., Katsch, L., Fahmi, A., Pein-Hackelbusch, M., & Schneider, J. (2024). Der rPET Gehalt in Flaschen - eine Frage des Glaubens? . GDL Kongress Lebensmitteltechnologie, Lemgo. bjps: Trilling-Haasler M et al. (2024) Der rPET Gehalt in Flaschen - eine Frage des Glaubens? . . chicago: Trilling-Haasler, Marc, Linda Katsch, Amir Fahmi, Miriam Pein-Hackelbusch, and Jan Schneider. Der rPET Gehalt in Flaschen - eine Frage des Glaubens? , 2024. chicago-de: Trilling-Haasler, Marc, Linda Katsch, Amir Fahmi, Miriam Pein-Hackelbusch und Jan Schneider. 2024. Der rPET Gehalt in Flaschen - eine Frage des Glaubens? . din1505-2-1: 'Trilling-Haasler, Marc ; Katsch, Linda ; Fahmi, Amir ; Pein-Hackelbusch, Miriam ; Schneider, Jan: Der rPET Gehalt in Flaschen - eine Frage des Glaubens? , 2024' havard: M. Trilling-Haasler, L. Katsch, A. Fahmi, M. Pein-Hackelbusch, J. Schneider, Der rPET Gehalt in Flaschen - eine Frage des Glaubens? , 2024. ieee: M. Trilling-Haasler, L. Katsch, A. Fahmi, M. Pein-Hackelbusch, and J. Schneider, Der rPET Gehalt in Flaschen - eine Frage des Glaubens? . 2024. mla: Trilling-Haasler, Marc, et al. Der rPET Gehalt in Flaschen - eine Frage des Glaubens? . 2024. short: M. Trilling-Haasler, L. Katsch, A. Fahmi, M. Pein-Hackelbusch, J. Schneider, Der rPET Gehalt in Flaschen - eine Frage des Glaubens? , 2024. ufg: 'Trilling-Haasler, Marc u. a.: Der rPET Gehalt in Flaschen - eine Frage des Glaubens? , o. O. 2024.' van: Trilling-Haasler M, Katsch L, Fahmi A, Pein-Hackelbusch M, Schneider J. Der rPET Gehalt in Flaschen - eine Frage des Glaubens? . 2024. conference: end_date: 2024-10-12 location: Lemgo name: GDL Kongress Lebensmitteltechnologie start_date: 2024-10-10 date_created: 2024-11-04T15:34:37Z date_updated: 2025-10-17T18:29:07Z department: - _id: DEP4018 - _id: DEP4028 - _id: DEP1308 language: - iso: ger publication_status: published status: public title: 'Der rPET Gehalt in Flaschen - eine Frage des Glaubens? ' type: conference_speech user_id: '81304' year: '2024' ... --- _id: '12400' abstract: - lang: eng text: Determining cell density and cell viability is fundamental for any cell cultivation process. In addition to the manual counting method using hemocytometers, (semi-)automated methods offer advantages such as lower variability and shortened analysis times. However, these methods should provide at least comparable results to the manual method, which is why a comparison of methods is essential. We conducted a dilution series experimental design according to ISO 20391-2:2019 and compared two cell counting methods based on validation parameters aligned with the ICH Q2(R1) guideline. Regarding specificity and linearity, the manual (hemocytometer) and semi-automated (Countstar BioTech®) method exhibited similar results in the two evaluated characteristics total cell density and cell viability of CHO-K1 cells. Regarding repeatability of determining total cell density, the semi-automated method achieved significant (α = 0.05) better results with average relative standard deviations of < 6 %, than the manual method with average relative standard deviations of > 9 %. Concerning repeatability of the cell viability measurement, no significant difference between the two methods were shown. These results show the suitabililty of the dilution series experimental design. For the applied example, they indicate that the investigated semi-automated method is an appropriate alternative to the manual method. author: - first_name: Selina full_name: Ramm, Selina id: '68713' last_name: Ramm orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Ulrich full_name: Odefey, Ulrich id: '74218' last_name: Odefey - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: 'Ramm S, Odefey U, Frahm B, Pein-Hackelbusch M. Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters. Published online 2024. doi:10.1101/2024.05.30.596619' apa: 'Ramm, S., Odefey, U., Frahm, B., & Pein-Hackelbusch, M. (2024). Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters. bioRxiv. https://doi.org/10.1101/2024.05.30.596619' bjps: 'Ramm S et al. (2024) Semi-Automated vs. Manual: Comparative Study of Cell Culture Counting Methods Using Validation Parameters.' chicago: 'Ramm, Selina, Ulrich Odefey, Björn Frahm, and Miriam Pein-Hackelbusch. “Semi-Automated vs. Manual: Comparative Study of Cell Culture Counting Methods Using Validation Parameters.” bioRxiv, 2024. https://doi.org/10.1101/2024.05.30.596619.' chicago-de: 'Ramm, Selina, Ulrich Odefey, Björn Frahm und Miriam Pein-Hackelbusch. 2024. Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters. bioRxiv. doi:10.1101/2024.05.30.596619, .' din1505-2-1: 'Ramm, Selina ; Odefey, Ulrich ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters, bioRxiv (2024)' havard: 'S. Ramm, U. Odefey, B. Frahm, M. Pein-Hackelbusch, Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters, (2024).' ieee: 'S. Ramm, U. Odefey, B. Frahm, and M. Pein-Hackelbusch, “Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters.” bioRxiv, 2024. doi: 10.1101/2024.05.30.596619.' mla: 'Ramm, Selina, et al. Semi-Automated vs. Manual: Comparative Study of Cell Culture Counting Methods Using Validation Parameters. bioRxiv, 2024, https://doi.org/10.1101/2024.05.30.596619.' short: S. Ramm, U. Odefey, B. Frahm, M. Pein-Hackelbusch, (2024). ufg: 'Ramm, Selina u. a.: Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters, o. O. 2024.' van: 'Ramm S, Odefey U, Frahm B, Pein-Hackelbusch M. Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters. bioRxiv; 2024.' date_created: 2025-01-29T13:48:31Z date_updated: 2025-07-29T13:23:30Z department: - _id: DEP4000 - _id: DEP4028 - _id: DEP4014 doi: 10.1101/2024.05.30.596619 language: - iso: eng main_file_link: - open_access: '1' url: https://www.biorxiv.org/content/10.1101/2024.05.30.596619v1 oa: '1' publication_status: published publisher: bioRxiv status: public title: 'Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters' type: preprint user_id: '83781' year: '2024' ... --- _id: '13650' author: - first_name: Selina full_name: Uhlendorff, Selina id: '68713' last_name: Uhlendorff orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Uhlendorff S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities.; 2023. apa: Uhlendorff, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. IEEE International Conference on Industrial Informatics, INDIN ’23, Lemgo, Germany. bjps: Uhlendorff S et al. (2023) Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. . chicago: Uhlendorff, Selina, Tanja Hernández Rodriguez, Björn Frahm, and Miriam Pein-Hackelbusch. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023. chicago-de: Uhlendorff, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. 2023. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. din1505-2-1: 'Uhlendorff, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023' havard: S. Uhlendorff, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023. ieee: S. Uhlendorff, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. 2023. mla: Uhlendorff, Selina, et al. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. 2023. short: S. Uhlendorff, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, 2023. ufg: 'Uhlendorff, Selina u. a.: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, o. O. 2023.' van: Uhlendorff S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. 2023. conference: end_date: 2023-07-20 location: Lemgo, Germany name: IEEE International Conference on Industrial Informatics, INDIN ’23 start_date: 2023-07-17 date_created: 2026-03-27T16:43:01Z date_updated: 2026-04-08T13:09:47Z department: - _id: DEP4000 language: - iso: eng status: public title: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities type: conference_speech user_id: '83778' year: '2023' ... --- _id: '10788' abstract: - lang: eng text: For process monitoring, an adequate data preprocessing is crucial to link accessible inline process data with offline measured target variables. Literature, however, does not provide systematic preprocessing strategies. The effects of five different preprocessing strategies on data from a Dielectric Spectroscopy system applied to the Viable Cell Density (VCD) of a mammalian cell cultivation were thus evaluated. Single-frequency measurements are typically used to model the VCD over the growth phase using linear regression or the Cole-Cole model and served as a reference. As multi-frequency measurement is promising to model the VCD beyond the growth phase using Partial Least Squares Regression (PLSR), we further aimed to determine, whether replacing linear regression by PLSR shows comparable modeling performance. All five preprocessing strategies led to comparable results. Exemplary, when using capacitance values at a frequency of 3347 kHz, linear regression resulted in a R2 of 0.90 and a standard deviation of 0.4 % on average. Both normalization techniques had the same positive effect on the results of PLSR. The order of smoothing and normalization was irrelevant for both regression methods. Comparing the results of linear regression and PLSR, the latter obtained on average 9 % better results. Therefore, we concluded that PLSR is preferable over linear regression and is potentially suitable to model the VCD beyond the growth phase, which is suggested to be investigated based on more data sets. author: - first_name: Selina full_name: Ramm, Selina id: '68713' last_name: Ramm orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. (Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , eds.). IEEE; 2023:1-6. doi:10.1109/INDIN51400.2023.10218012 apa: Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. In J. Jasperneite, L. Wisniewski, K. Fung Man, & Institute of Electrical and Electronics Engineers (Eds.), 2023 IEEE 21st International Conference on Industrial Informatics (INDIN) (pp. 1–6). IEEE. https://doi.org/10.1109/INDIN51400.2023.10218012 bjps: 'Ramm S et al. (2023) Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, Jasperneite J et al. (eds). [Piscataway, NJ]: IEEE.' chicago: 'Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm, and Miriam Pein-Hackelbusch. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. Edited by Jürgen Jasperneite, Lukasz Wisniewski, Kim Fung Man, and Institute of Electrical and Electronics Engineers . 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE, 2023. https://doi.org/10.1109/INDIN51400.2023.10218012.' chicago-de: 'Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. 2023. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. Hg. von Jürgen Jasperneite, Lukasz Wisniewski, Kim Fung Man, und Institute of Electrical and Electronics Engineers . 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE. doi:10.1109/INDIN51400.2023.10218012, .' din1505-2-1: 'Ramm, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam ; Jasperneite, J. ; Wisniewski, L. ; Fung Man, K. ; Institute of Electrical and Electronics Engineers (Hrsg.): Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. [Piscataway, NJ] : IEEE, 2023' havard: S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023. ieee: 'S. Ramm, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. [Piscataway, NJ]: IEEE, 2023, pp. 1–6. doi: 10.1109/INDIN51400.2023.10218012.' mla: Ramm, Selina, et al. “Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities.” 2023 IEEE 21st International Conference on Industrial Informatics (INDIN), edited by Jürgen Jasperneite et al., IEEE, 2023, pp. 1–6, https://doi.org/10.1109/INDIN51400.2023.10218012. short: S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023. ufg: 'Ramm, Selina u. a.: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, hg. von Jasperneite, Jürgen u. a., [Piscataway, NJ] 2023.' van: 'Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities. Jasperneite J, Wisniewski L, Fung Man K, Institute of Electrical and Electronics Engineers , editors. 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). [Piscataway, NJ]: IEEE; 2023.' conference: end_date: 2023-07-20 location: Lemgo name: 21st International Conference on Industrial Informatics (INDIN) start_date: 2023-07-18 corporate_editor: - 'Institute of Electrical and Electronics Engineers ' date_created: 2023-11-21T08:17:12Z date_updated: 2025-04-29T07:38:03Z department: - _id: DEP4022 - _id: DEP4028 doi: 10.1109/INDIN51400.2023.10218012 editor: - first_name: Jürgen full_name: Jasperneite, Jürgen id: '1899' last_name: Jasperneite - first_name: Lukasz full_name: Wisniewski, Lukasz id: '1710' last_name: Wisniewski - first_name: Kim full_name: Fung Man, Kim last_name: Fung Man keyword: - Spectroscopy - Smoothing methods - Systematics - Phase measurement - Linear regression - Data models - Dielectric measurement language: - iso: eng main_file_link: - open_access: '1' url: https://ieeexplore.ieee.org/document/10218012 oa: '1' page: 1-6 place: '[Piscataway, NJ]' publication: 2023 IEEE 21st International Conference on Industrial Informatics (INDIN) publication_identifier: eisbn: - 978-1-6654-9313-0 isbn: - 978-1-6654-9314-7 issn: - 1935-4576 publication_status: published publisher: IEEE status: public title: Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities type: conference_editor_article user_id: '83781' year: '2023' ... --- _id: '11487' author: - first_name: Selina full_name: Ramm, Selina id: '68713' last_name: Ramm orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Tanja full_name: Hernández Rodriguez, Tanja id: '52466' last_name: Hernández Rodriguez - first_name: Björn full_name: Frahm, Björn id: '45666' last_name: Frahm - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression . DECHEMA e.V. apa: Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (n.d.). Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression . 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Berlin, Germany. DECHEMA e.V. bjps: Ramm S et al. (n.d.) Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression . DECHEMA e.V. chicago: Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm, and Miriam Pein-Hackelbusch. Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression . DECHEMA e.V., n.d. chicago-de: Ramm, Selina, Tanja Hernández Rodriguez, Björn Frahm und Miriam Pein-Hackelbusch. Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression . DECHEMA e.V. din1505-2-1: 'Ramm, Selina ; Hernández Rodriguez, Tanja ; Frahm, Björn ; Pein-Hackelbusch, Miriam: Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression  : DECHEMA e.V.' havard: S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d. ieee: S. Ramm, T. Hernández Rodriguez, B. Frahm, and M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression . DECHEMA e.V. mla: Ramm, Selina, et al. Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression . DECHEMA e.V. short: S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d. ufg: 'Ramm, Selina u. a.: Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , o. O. u. J. .' van: Ramm S, Hernández Rodriguez T, Frahm B, Pein-Hackelbusch M. Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression . DECHEMA e.V.; conference: end_date: 2023-09-21 location: Berlin, Germany name: 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology start_date: 2023-09-17 date_created: 2024-05-21T09:37:09Z date_updated: 2024-05-21T09:37:15Z department: - _id: DEP4000 language: - iso: eng main_file_link: - open_access: '1' url: http://www.apz-rl.de/BioProcessingDays_2023/002_download/BPDs_2023_Tagungsbuch_Titel.pdf oa: '1' publication_status: accepted publisher: DECHEMA e.V. status: public title: 'Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression ' type: conference_poster user_id: '83781' year: '2023' ... --- _id: '10216' abstract: - lang: eng text: Wet granulation is a frequent process in the pharmaceutical industry. As a starting point for numerous dosage forms, the quality of the granulation not only affects subsequent production steps but also impacts the quality of the final product. It is thus crucial and economical to monitor this operation thoroughly. Here, we report on identifying different phases of a granulation process using a machine learning approach. The phases reflect the water content which, in turn, influences the processability and quality of the granule mass. We used two kinds of microphones and an acceleration sensor to capture acoustic emissions and vibrations. We trained convolutional neural networks (CNNs) to classify the different phases using transformed sound recordings as the input. We achieved a classification accuracy of up to 90% using vibrational data and an accuracy of up to 97% using the audible microphone data. Our results indicate the suitability of using audible sound and machine learning to monitor pharmaceutical processes. Moreover, since recording acoustic emissions is contactless, it readily complies with legal regulations and presents Good Manufacturing Practices. article_number: '2153' author: - first_name: Ruwen full_name: Fulek, Ruwen id: '79527' last_name: Fulek - first_name: Selina full_name: Ramm, Selina id: '68713' last_name: Ramm orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Christian full_name: Kiera, Christian last_name: Kiera - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 - first_name: Ulrich full_name: Odefey, Ulrich id: '74218' last_name: Odefey citation: ama: Fulek R, Ramm S, Kiera C, Pein-Hackelbusch M, Odefey U. A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. Pharmaceutics. 2023;15(8). doi:https://doi.org/10.3390/pharmaceutics15082153 apa: Fulek, R., Ramm, S., Kiera, C., Pein-Hackelbusch, M., & Odefey, U. (2023). A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. Pharmaceutics, 15(8), Article 2153. https://doi.org/10.3390/pharmaceutics15082153 bjps: Fulek R et al. (2023) A Machine Learning Approach to Qualitatively Evaluate Different Granulation Phases by Acoustic Emissions. Pharmaceutics 15. chicago: Fulek, Ruwen, Selina Ramm, Christian Kiera, Miriam Pein-Hackelbusch, and Ulrich Odefey. “A Machine Learning Approach to Qualitatively Evaluate Different Granulation Phases by Acoustic Emissions.” Pharmaceutics 15, no. 8 (2023). https://doi.org/10.3390/pharmaceutics15082153. chicago-de: Fulek, Ruwen, Selina Ramm, Christian Kiera, Miriam Pein-Hackelbusch und Ulrich Odefey. 2023. A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. Pharmaceutics 15, Nr. 8. doi:https://doi.org/10.3390/pharmaceutics15082153, . din1505-2-1: 'Fulek, Ruwen ; Ramm, Selina ; Kiera, Christian ; Pein-Hackelbusch, Miriam ; Odefey, Ulrich: A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. In: Pharmaceutics Bd. 15. Basel, MDPI (2023), Nr. 8' havard: R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, U. Odefey, A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions, Pharmaceutics. 15 (2023). ieee: 'R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, and U. Odefey, “A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions,” Pharmaceutics, vol. 15, no. 8, Art. no. 2153, 2023, doi: https://doi.org/10.3390/pharmaceutics15082153.' mla: Fulek, Ruwen, et al. “A Machine Learning Approach to Qualitatively Evaluate Different Granulation Phases by Acoustic Emissions.” Pharmaceutics, vol. 15, no. 8, 2153, 2023, https://doi.org/10.3390/pharmaceutics15082153. short: R. Fulek, S. Ramm, C. Kiera, M. Pein-Hackelbusch, U. Odefey, Pharmaceutics 15 (2023). ufg: 'Fulek, Ruwen u. a.: A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions, in: Pharmaceutics 15 (2023), H. 8.' van: Fulek R, Ramm S, Kiera C, Pein-Hackelbusch M, Odefey U. A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions. Pharmaceutics. 2023;15(8). date_created: 2023-08-15T10:48:15Z date_updated: 2025-07-29T13:21:40Z department: - _id: DEP4022 - _id: DEP4028 - _id: DEP4014 doi: https://doi.org/10.3390/pharmaceutics15082153 external_id: isi: - '001119084200001' pmid: - '37631367' intvolume: ' 15' isi: '1' issue: '8' keyword: - wet granulation - acoustic classification - machine learning - convolutional neural networks language: - iso: eng main_file_link: - open_access: '1' url: https://www.mdpi.com/1999-4923/15/8/2153 oa: '1' place: Basel pmid: '1' publication: Pharmaceutics publication_identifier: eissn: - '1999-4923 ' publication_status: published publisher: MDPI quality_controlled: '1' status: public title: A machine learning approach to qualitatively evaluate different granulation phases by acoustic emissions type: scientific_journal_article user_id: '83781' volume: 15 year: '2023' ... --- _id: '10326' abstract: - lang: eng text: In the food industry, and especially in wines as products thereof, ethanol and sulfur dioxide play an equally important role. Both substances are important wine quality characteristics as they influence the taste and odor. As both substances comprise volatile matter, electronic noses should be applicable to discriminate the different qualities of wines. Our study investigates the influence of alcohol and sulfur dioxide on the discrimination ability of wines (especially those of the same grape variety) using two different electronic nose systems. One system is equipped with metal oxide sensors and the other with quartz crystal microbalance sensors. Contrary to indications in literature, where the alcohol content is discussed to have a large influence on e-nose results, it was shown that a difference of 1 % ethanol was not sufficient to allow accurate discrimination using Linear Discriminant Analysis by any system. On the positive side, the analyzed concentrations of ethanol (about 12 %) did not superimpose other volatile information. So difference in sulfur dioxide content gave an accuracy for sample discrimination of up to 90.6 % with MOS nose. Thus, we are so far partially able to discriminate wines with electronic noses based on their volatile imprint. author: - first_name: Julius full_name: Wörner, Julius id: '79011' last_name: Wörner - first_name: Helene full_name: Dörksen, Helene id: '46416' last_name: Dörksen - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Wörner J, Dörksen H, Pein-Hackelbusch M. Key Indicators for the Discrimination of Wines by Electronic Noses.; 2023. doi:https://doi.org/10.1109/INDIN51400.2023.10217912 apa: Wörner, J., Dörksen, H., & Pein-Hackelbusch, M. (2023). Key Indicators for the Discrimination of Wines by Electronic Noses. In 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). 21st International Conference on Industrial Informatics (INDIN), Lemgo. https://doi.org/10.1109/INDIN51400.2023.10217912 bjps: Wörner J, Dörksen H and Pein-Hackelbusch M (2023) Key Indicators for the Discrimination of Wines by Electronic Noses. . chicago: Wörner, Julius, Helene Dörksen, and Miriam Pein-Hackelbusch. Key Indicators for the Discrimination of Wines by Electronic Noses. 2023 IEEE 21st International Conference on Industrial Informatics (INDIN), 2023. https://doi.org/10.1109/INDIN51400.2023.10217912. chicago-de: Wörner, Julius, Helene Dörksen und Miriam Pein-Hackelbusch. 2023. Key Indicators for the Discrimination of Wines by Electronic Noses. 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). doi:https://doi.org/10.1109/INDIN51400.2023.10217912, . din1505-2-1: 'Wörner, Julius ; Dörksen, Helene ; Pein-Hackelbusch, Miriam: Key Indicators for the Discrimination of Wines by Electronic Noses, 2023' havard: J. Wörner, H. Dörksen, M. Pein-Hackelbusch, Key Indicators for the Discrimination of Wines by Electronic Noses, 2023. ieee: 'J. Wörner, H. Dörksen, and M. Pein-Hackelbusch, Key Indicators for the Discrimination of Wines by Electronic Noses. 2023. doi: https://doi.org/10.1109/INDIN51400.2023.10217912.' mla: Wörner, Julius, et al. “Key Indicators for the Discrimination of Wines by Electronic Noses.” 2023 IEEE 21st International Conference on Industrial Informatics (INDIN), 2023, https://doi.org/10.1109/INDIN51400.2023.10217912. short: J. Wörner, H. Dörksen, M. Pein-Hackelbusch, Key Indicators for the Discrimination of Wines by Electronic Noses, 2023. ufg: 'Wörner, Julius/Dörksen, Helene/Pein-Hackelbusch, Miriam: Key Indicators for the Discrimination of Wines by Electronic Noses, o. O. 2023.' van: Wörner J, Dörksen H, Pein-Hackelbusch M. Key Indicators for the Discrimination of Wines by Electronic Noses. 2023 IEEE 21st International Conference on Industrial Informatics (INDIN). 2023. conference: end_date: 2023-07-20 location: Lemgo name: 21st International Conference on Industrial Informatics (INDIN) start_date: 2023-07-18 date_created: 2023-09-14T05:50:47Z date_updated: 2025-03-13T13:48:05Z department: - _id: DEP4000 - _id: DEP4028 doi: https://doi.org/10.1109/INDIN51400.2023.10217912 keyword: - Ethanol - Pipelines - Metals - Nose - Electronic noses - Sensor systems - Sensors - Quartz crystals - Linear discriminant analysis - Sulfur language: - iso: eng main_file_link: - open_access: '1' url: https://ieeexplore.ieee.org/document/10217912 oa: '1' publication: 2023 IEEE 21st International Conference on Industrial Informatics (INDIN) publication_status: published status: public title: Key Indicators for the Discrimination of Wines by Electronic Noses type: conference_speech user_id: '64952' year: '2023' ... --- _id: '10327' abstract: - lang: eng text: 'Wound infections are a major problem worldwide, both for the healthcare system and for patients affected. Currently available diagnostic methods to determine the responsible germs are time-consuming and costly. Wound infections are mostly caused by various bacteria, which in turn produce volatile organic compounds. From clinical experience, we know that depending on the bacteria involved, a specific odor impression can be expected. For this reason, we hypothesized that electronic noses, i.e., non-invasive electronic sensors for the detection of volatile organic compounds, are applicable for diagnostic purposes. By providing a comprehensive overview of the state-of-research, we tested our hypothesis. In particular, we addressed three overarching questions: 1) which sensor technologies are suitable for the diagnosis of wound infections and why? 2) how must the (biological) sample be prepared and presented to the measurement system? 3) which machine learning methods and algorithms have already proven successful for the classification of microorganisms? The corresponding articles have critically been reviewed and are discussed particularly in the context of their potential for clinical diagnostics. In summary, it can already be stated today that the use of electronic noses for the detection of bacteria in wound infections is a very interesting, fast and non-invasive method. However, reliable clinical studies are still missing and further research is necessary.' author: - first_name: Julius full_name: Wörner, Julius id: '79011' last_name: Wörner - first_name: Maurice full_name: Moelleken, Maurice last_name: Moelleken - first_name: Joachim full_name: Dissemond, Joachim last_name: Dissemond - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: 'Wörner J, Moelleken M, Dissemond J, Pein-Hackelbusch M. Supporting wound infection diagnosis: advancements and challenges with electronic noses. Frontiers in Sensors. 2023;4. doi:https://doi.org/10.3389/fsens.2023.1250756' apa: 'Wörner, J., Moelleken, M., Dissemond, J., & Pein-Hackelbusch, M. (2023). Supporting wound infection diagnosis: advancements and challenges with electronic noses. Frontiers in Sensors, 4. https://doi.org/10.3389/fsens.2023.1250756' bjps: 'Wörner J et al. (2023) Supporting Wound Infection Diagnosis: Advancements and Challenges with Electronic Noses. Frontiers in Sensors 4.' chicago: 'Wörner, Julius, Maurice Moelleken, Joachim Dissemond, and Miriam Pein-Hackelbusch. “Supporting Wound Infection Diagnosis: Advancements and Challenges with Electronic Noses.” Frontiers in Sensors 4 (2023). https://doi.org/10.3389/fsens.2023.1250756.' chicago-de: 'Wörner, Julius, Maurice Moelleken, Joachim Dissemond und Miriam Pein-Hackelbusch. 2023. Supporting wound infection diagnosis: advancements and challenges with electronic noses. Frontiers in Sensors 4. doi:https://doi.org/10.3389/fsens.2023.1250756, .' din1505-2-1: 'Wörner, Julius ; Moelleken, Maurice ; Dissemond, Joachim ; Pein-Hackelbusch, Miriam: Supporting wound infection diagnosis: advancements and challenges with electronic noses. In: Frontiers in Sensors Bd. 4.   Lausanne , Frontiers Media (2023)' havard: 'J. Wörner, M. Moelleken, J. Dissemond, M. Pein-Hackelbusch, Supporting wound infection diagnosis: advancements and challenges with electronic noses, Frontiers in Sensors. 4 (2023).' ieee: 'J. Wörner, M. Moelleken, J. Dissemond, and M. Pein-Hackelbusch, “Supporting wound infection diagnosis: advancements and challenges with electronic noses,” Frontiers in Sensors, vol. 4, 2023, doi: https://doi.org/10.3389/fsens.2023.1250756.' mla: 'Wörner, Julius, et al. “Supporting Wound Infection Diagnosis: Advancements and Challenges with Electronic Noses.” Frontiers in Sensors, vol. 4, 2023, https://doi.org/10.3389/fsens.2023.1250756.' short: J. Wörner, M. Moelleken, J. Dissemond, M. Pein-Hackelbusch, Frontiers in Sensors 4 (2023). ufg: 'Wörner, Julius u. a.: Supporting wound infection diagnosis: advancements and challenges with electronic noses, in: Frontiers in Sensors 4 (2023).' van: 'Wörner J, Moelleken M, Dissemond J, Pein-Hackelbusch M. Supporting wound infection diagnosis: advancements and challenges with electronic noses. Frontiers in Sensors. 2023;4.' date_created: 2023-09-14T05:55:33Z date_updated: 2025-03-13T14:07:57Z department: - _id: DEP4000 - _id: DEP4028 doi: https://doi.org/10.3389/fsens.2023.1250756 intvolume: ' 4' language: - iso: eng main_file_link: - open_access: '1' url: https://www.frontiersin.org/articles/10.3389/fsens.2023.1250756/full oa: '1' place: ' Lausanne ' publication: Frontiers in Sensors publication_identifier: eissn: - 2673-5067 publication_status: published publisher: Frontiers Media quality_controlled: '1' status: public title: 'Supporting wound infection diagnosis: advancements and challenges with electronic noses' type: scientific_journal_article user_id: '64952' volume: 4 year: '2023' ... --- _id: '12705' abstract: - lang: eng text: This dataset contains spectroscopic measurement data and Orange project files used in the INDIN 2023 paper "A Novel Spectroscopic Approach for Vaseline Quality Discrimination". author: - first_name: Niels Hendrik full_name: Fliedner, Niels Hendrik id: '58709' last_name: Fliedner - first_name: Volker full_name: Lohweg, Volker id: '1804' last_name: Lohweg orcid: 0000-0002-3325-7887 - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Fliedner NH, Lohweg V, Pein-Hackelbusch M. Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination. zenodo; 2023. doi:10.5281/ZENODO.7782807 apa: Fliedner, N. H., Lohweg, V., & Pein-Hackelbusch, M. (2023). Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination. zenodo. https://doi.org/10.5281/ZENODO.7782807 bjps: Fliedner NH, Lohweg V and Pein-Hackelbusch M (2023) Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination. zenodo. chicago: Fliedner, Niels Hendrik, Volker Lohweg, and Miriam Pein-Hackelbusch. Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination. zenodo, 2023. https://doi.org/10.5281/ZENODO.7782807. chicago-de: Fliedner, Niels Hendrik, Volker Lohweg und Miriam Pein-Hackelbusch. 2023. Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination. zenodo. doi:10.5281/ZENODO.7782807, . din1505-2-1: 'Fliedner, Niels Hendrik ; Lohweg, Volker ; Pein-Hackelbusch, Miriam: Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination : zenodo, 2023' havard: N.H. Fliedner, V. Lohweg, M. Pein-Hackelbusch, Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination, zenodo, 2023. ieee: 'N. H. Fliedner, V. Lohweg, and M. Pein-Hackelbusch, Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination. zenodo, 2023. doi: 10.5281/ZENODO.7782807.' mla: Fliedner, Niels Hendrik, et al. Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination. zenodo, 2023, https://doi.org/10.5281/ZENODO.7782807. short: N.H. Fliedner, V. Lohweg, M. Pein-Hackelbusch, Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination, zenodo, 2023. ufg: 'Fliedner, Niels Hendrik/Lohweg, Volker/Pein-Hackelbusch, Miriam: Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination, o. O. 2023.' van: Fliedner NH, Lohweg V, Pein-Hackelbusch M. Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination. zenodo; 2023. date_created: 2025-03-13T11:07:23Z date_updated: 2025-10-10T07:48:02Z department: - _id: DEP4028 doi: 10.5281/ZENODO.7782807 main_file_link: - open_access: '1' url: https://zenodo.org/records/7782808 oa: '1' publisher: zenodo status: public title: Dataset for A Novel Spectroscopic Approach for Vaseline Quality Discrimination type: research_data user_id: '64952' year: '2023' ... --- _id: '9627' author: - first_name: Selina full_name: Ramm, Selina id: '68713' last_name: Ramm orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Ruwen full_name: Fulek, Ruwen id: '79527' last_name: Fulek - first_name: Veronika Anna full_name: Eberle, Veronika Anna last_name: Eberle - first_name: Christian full_name: Kiera, Christian last_name: Kiera - first_name: Ulrich full_name: Odefey, Ulrich id: '74218' last_name: Odefey - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Ramm S, Fulek R, Eberle VA, Kiera C, Odefey U, Pein-Hackelbusch M. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation.; 2023. apa: Ramm, S., Fulek, R., Eberle, V. A., Kiera, C., Odefey, U., & Pein-Hackelbusch, M. (2023). Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. Ph.D. Student’s Symposium on Tabletting Technology 2023, Rosenberg. bjps: Ramm S et al. (2023) Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. . chicago: Ramm, Selina, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich Odefey, and Miriam Pein-Hackelbusch. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation, 2023. chicago-de: Ramm, Selina, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich Odefey und Miriam Pein-Hackelbusch. 2023. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. din1505-2-1: 'Ramm, Selina ; Fulek, Ruwen ; Eberle, Veronika Anna ; Kiera, Christian ; Odefey, Ulrich ; Pein-Hackelbusch, Miriam: Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation, 2023' havard: S. Ramm, R. Fulek, V.A. Eberle, C. Kiera, U. Odefey, M. Pein-Hackelbusch, Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation, 2023. ieee: S. Ramm, R. Fulek, V. A. Eberle, C. Kiera, U. Odefey, and M. Pein-Hackelbusch, Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. 2023. mla: Ramm, Selina, et al. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. 2023. short: S. Ramm, R. Fulek, V.A. Eberle, C. Kiera, U. Odefey, M. Pein-Hackelbusch, Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation, 2023. ufg: 'Ramm, Selina u. a.: Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation, o. O. 2023.' van: Ramm S, Fulek R, Eberle VA, Kiera C, Odefey U, Pein-Hackelbusch M. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. 2023. conference: end_date: 2023-03-15 location: Rosenberg name: Ph.D. Student's Symposium on Tabletting Technology 2023 start_date: 2023-03-13 date_created: 2023-03-16T09:46:10Z date_updated: 2025-07-29T13:23:12Z department: - _id: DEP4022 - _id: DEP4028 - _id: DEP4014 language: - iso: eng publication_status: published status: public title: Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation type: conference_speech user_id: '83781' year: '2023' ... --- _id: '9568' abstract: - lang: eng text: Pellet production is a multi-step manufacturing process comprising granulation, extrusion and spheronisation. The first step represents a critical control point, since the quality of the granule mass highly influences subsequent process steps and, consequently, the quality of final pellets. The most important parameter of wet granulation is the liquid requirement, which can often only be quantitatively evaluated after further process steps. To identify an alternative for optimal liquid requirements, experiments were conducted with a formulation based on lactose and microcrystalline cellulose. Granules were analyzed with a Powder Vertical Shear Rig. We identified the compression density (ρpress) as the said alternative, linking information from the powder material and the moisture content (R2 = 0.995). We used ρpress to successfully predict liquid requirements for unknown formulation compositions. By means of this prediction, pellets with high quality, regarding shape and size distribution, were produced by carrying out a multi-step manufacturing process. Furthermore, the applicability of ρpress as an alternative quality parameter to other placebo formulations and to formulations containing active pharmaceutical ingredients (APIs) was demonstrated. article_number: '2303' author: - first_name: Selina full_name: Ramm, Selina id: '68713' last_name: Ramm orcid: https://orcid.org/0000-0002-0502-8032 - first_name: Ruwen full_name: Fulek, Ruwen id: '79527' last_name: Fulek - first_name: Veronika Anna full_name: Eberle, Veronika Anna last_name: Eberle - first_name: Christian full_name: Kiera, Christian last_name: Kiera - first_name: Ulrich full_name: Odefey, Ulrich id: '74218' last_name: Odefey - first_name: Miriam full_name: Pein-Hackelbusch, Miriam id: '64952' last_name: Pein-Hackelbusch orcid: 0000-0002-7920-0595 citation: ama: Ramm S, Fulek R, Eberle VA, Kiera C, Odefey U, Pein-Hackelbusch M. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. Pharmaceutics. 2022;14(11). doi:https://doi.org/10.3390/pharmaceutics14112303 apa: Ramm, S., Fulek, R., Eberle, V. A., Kiera, C., Odefey, U., & Pein-Hackelbusch, M. (2022). Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. Pharmaceutics, 14(11), Article 2303. https://doi.org/10.3390/pharmaceutics14112303 bjps: Ramm S et al. (2022) Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. Pharmaceutics 14. chicago: Ramm, Selina, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich Odefey, and Miriam Pein-Hackelbusch. “Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation.” Pharmaceutics 14, no. 11 (2022). https://doi.org/10.3390/pharmaceutics14112303. chicago-de: Ramm, Selina, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich Odefey und Miriam Pein-Hackelbusch. 2022. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. Pharmaceutics 14, Nr. 11. doi:https://doi.org/10.3390/pharmaceutics14112303, . din1505-2-1: 'Ramm, Selina ; Fulek, Ruwen ; Eberle, Veronika Anna ; Kiera, Christian ; Odefey, Ulrich ; Pein-Hackelbusch, Miriam: Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. In: Pharmaceutics Bd. 14. Basel, MDPI (2022), Nr. 11' havard: S. Ramm, R. Fulek, V.A. Eberle, C. Kiera, U. Odefey, M. Pein-Hackelbusch, Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation., Pharmaceutics. 14 (2022). ieee: 'S. Ramm, R. Fulek, V. A. Eberle, C. Kiera, U. Odefey, and M. Pein-Hackelbusch, “Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation.,” Pharmaceutics, vol. 14, no. 11, Art. no. 2303, 2022, doi: https://doi.org/10.3390/pharmaceutics14112303.' mla: Ramm, Selina, et al. “Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation.” Pharmaceutics, vol. 14, no. 11, 2303, 2022, https://doi.org/10.3390/pharmaceutics14112303. short: S. Ramm, R. Fulek, V.A. Eberle, C. Kiera, U. Odefey, M. Pein-Hackelbusch, Pharmaceutics 14 (2022). ufg: 'Ramm, Selina u. a.: Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation., in: Pharmaceutics 14 (2022), H. 11.' van: Ramm S, Fulek R, Eberle VA, Kiera C, Odefey U, Pein-Hackelbusch M. Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. Pharmaceutics. 2022;14(11). date_created: 2023-03-03T11:23:01Z date_updated: 2025-07-29T13:22:53Z department: - _id: DEP4022 - _id: DEP4028 - _id: DEP4014 doi: https://doi.org/10.3390/pharmaceutics14112303 external_id: isi: - '000883998100001' pmid: - '36365122' intvolume: ' 14' isi: '1' issue: '11' keyword: - wet granulation - liquid requirement - granulation endpoint - compression density language: - iso: eng main_file_link: - open_access: '1' url: https://www.mdpi.com/1999-4923/14/11/2303 oa: '1' place: Basel pmid: '1' publication: Pharmaceutics publication_identifier: eissn: - 1999-4923 publication_status: published publisher: MDPI status: public title: Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation. type: scientific_journal_article user_id: '83781' volume: 14 year: '2022' ...