[{"abstract":[{"text":"Antibodies represent an important element in the adaptive immune response and a major tool to eliminate microbial pathogens. For many bacterial and viral infections, efficient vaccines exist, but not for fungal pathogens. For a long time, antibodies have been assumed to be of minor importance for a successful clearance of fungal infections; however this perception has been challenged by a large number of studies over the last three decades. In this review, we focus on the potential therapeutic and prophylactic use of monoclonal antibodies. Since systemic mycoses normally occur in severely immunocompromised patients, a passive immunization using monoclonal antibodies is a promising approach to directly attack the fungal pathogen and/or to activate and strengthen the residual antifungal immune response in these patients.","lang":"eng"}],"keyword":["monoclonal antibodies","invasive fungal infections","therapy","prophylaxis","opsonization"],"extern":"1","status":"public","department":[{"_id":"DEP4010"}],"year":"2020","user_id":"83781","quality_controlled":"1","date_updated":"2025-06-18T11:13:40Z","doi":"10.3390/jof6010022","issue":"1","publisher":"MDPI ","type":"scientific_journal_article","article_number":"22","_id":"12964","publication":"Journal of Fungi","title":"Monoclonal Antibodies as Tools to Combat Fungal Infections","language":[{"iso":"eng"}],"date_created":"2025-06-15T10:17:00Z","volume":6,"publication_status":"published","place":"Basel","citation":{"ufg":"<b>Ulrich, Sebastian/Ebel, Frank</b>: Monoclonal Antibodies as Tools to Combat Fungal Infections, in: <i>Journal of Fungi</i> 6 (2020), H. 1.","chicago-de":"Ulrich, Sebastian und Frank Ebel. 2020. Monoclonal Antibodies as Tools to Combat Fungal Infections. <i>Journal of Fungi</i> 6, Nr. 1. doi:<a href=\"https://doi.org/10.3390/jof6010022\">10.3390/jof6010022</a>, .","short":"S. Ulrich, F. Ebel, Journal of Fungi 6 (2020).","apa":"Ulrich, S., &#38; Ebel, F. (2020). Monoclonal Antibodies as Tools to Combat Fungal Infections. <i>Journal of Fungi</i>, <i>6</i>(1), Article 22. <a href=\"https://doi.org/10.3390/jof6010022\">https://doi.org/10.3390/jof6010022</a>","mla":"Ulrich, Sebastian, and Frank Ebel. “Monoclonal Antibodies as Tools to Combat Fungal Infections.” <i>Journal of Fungi</i>, vol. 6, no. 1, 22, 2020, <a href=\"https://doi.org/10.3390/jof6010022\">https://doi.org/10.3390/jof6010022</a>.","havard":"S. Ulrich, F. Ebel, Monoclonal Antibodies as Tools to Combat Fungal Infections, Journal of Fungi. 6 (2020).","chicago":"Ulrich, Sebastian, and Frank Ebel. “Monoclonal Antibodies as Tools to Combat Fungal Infections.” <i>Journal of Fungi</i> 6, no. 1 (2020). <a href=\"https://doi.org/10.3390/jof6010022\">https://doi.org/10.3390/jof6010022</a>.","bjps":"<b>Ulrich S and Ebel F</b> (2020) Monoclonal Antibodies as Tools to Combat Fungal Infections. <i>Journal of Fungi</i> <b>6</b>.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Ulrich, Sebastian</span> ; <span style=\"font-variant:small-caps;\">Ebel, Frank</span>: Monoclonal Antibodies as Tools to Combat Fungal Infections. In: <i>Journal of Fungi</i> Bd. 6. Basel, MDPI  (2020), Nr. 1","van":"Ulrich S, Ebel F. Monoclonal Antibodies as Tools to Combat Fungal Infections. Journal of Fungi. 2020;6(1).","ama":"Ulrich S, Ebel F. Monoclonal Antibodies as Tools to Combat Fungal Infections. <i>Journal of Fungi</i>. 2020;6(1). doi:<a href=\"https://doi.org/10.3390/jof6010022\">10.3390/jof6010022</a>","ieee":"S. Ulrich and F. Ebel, “Monoclonal Antibodies as Tools to Combat Fungal Infections,” <i>Journal of Fungi</i>, vol. 6, no. 1, Art. no. 22, 2020, doi: <a href=\"https://doi.org/10.3390/jof6010022\">10.3390/jof6010022</a>."},"publication_identifier":{"eissn":["2309-608X"]},"intvolume":"         6","author":[{"orcid":"0000-0002-4511-9537","id":"85847","last_name":"Ulrich","full_name":"Ulrich, Sebastian","first_name":"Sebastian"},{"first_name":"Frank","full_name":"Ebel, Frank","last_name":"Ebel"}]},{"abstract":[{"lang":"eng","text":"This bachelor thesis explores the adaptive reuse of the former Telekom high-rise at Kesselbrink in Bielefeld, a vacant modernist office tower awaiting new purpose. The project proposes a mixed-use transformation that reinterprets the building as a “city within the city,” inspired by Le Corbusier’s Unité d’Habitation in Marseille. The existing structure is strategically reduced to its essential load-bearing concrete frame and floor slabs, preserving the structural skeleton while enabling radical spatial reconfiguration.\r\nPrefabricated timber modules are inserted and cantilevered between the reinforced-concrete columns, extending the usable floor area and introducing a warm, contemporary material contrast to the original façade. This intervention not only increases density and flexibility but also redefines the tower’s appearance, giving it a cosmopolitan and forward-looking architectural identity. The ground floor is conceived as an open and publicly accessible urban platform, activating the surrounding plaza and strengthening social interaction. Upper floors are redesigned as affordable and attractive living spaces for young residents, encouraging a diverse and vibrant community within the building.\r\nA newly designed park-like rooftop landscape provides recreational space and panoramic views over the city, enhancing environmental quality and urban connectivity. By combining structural preservation, modular timber construction, public programming, and residential reuse, the proposal demonstrates how high-rise retrofitting can generate social, ecological, and economic value simultaneously. The project positions adaptive reuse as a viable strategy for sustainable urban regeneration and architectural longevity."}],"supervisor":[{"first_name":"Hans","full_name":"Sachs, Hans","id":"64589","last_name":"Sachs"}],"extern":"1","_id":"13372","keyword":["Adaptive Reuse","Mixed-Use Development","High-Rise Transformation","City within the City","Modular Timber Construction","Prefabrication","Structural Preservation","Concrete Skeleton","Cantilevered Modules","Urban Regeneration","Public Ground Floor","Youth Housing","Rooftop Landscape","Sustainability","Social Impact","Ecological Design","Economic Viability","Cosmopolitan Architecture"],"status":"public","year":"2020","user_id":"83781","department":[{"_id":"DEP1600"}],"date_updated":"2026-02-20T07:09:36Z","title":"TreeTower","place":"Detmolder Schule für Gestaltung","citation":{"ieee":"L. Konschake, <i>TreeTower</i>. Detmolder Schule für Gestaltung: Technische Hochschule Ostwestfalen-Lippe, 2020.","ama":"Konschake L. <i>TreeTower</i>. Technische Hochschule Ostwestfalen-Lippe; 2020.","van":"Konschake L. TreeTower. Detmolder Schule für Gestaltung: Technische Hochschule Ostwestfalen-Lippe; 2020.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Konschake, Leon</span>: <i>TreeTower</i>. Detmolder Schule für Gestaltung : Technische Hochschule Ostwestfalen-Lippe, 2020","bjps":"<b>Konschake L</b> (2020) <i>TreeTower</i>. Detmolder Schule für Gestaltung: Technische Hochschule Ostwestfalen-Lippe.","chicago":"Konschake, Leon. <i>TreeTower</i>. Detmolder Schule für Gestaltung: Technische Hochschule Ostwestfalen-Lippe, 2020.","havard":"L. Konschake, TreeTower, Technische Hochschule Ostwestfalen-Lippe, Detmolder Schule für Gestaltung, 2020.","apa":"Konschake, L. (2020). <i>TreeTower</i>. Technische Hochschule Ostwestfalen-Lippe.","mla":"Konschake, Leon. <i>TreeTower</i>. Technische Hochschule Ostwestfalen-Lippe, 2020.","short":"L. Konschake, TreeTower, Technische Hochschule Ostwestfalen-Lippe, Detmolder Schule für Gestaltung, 2020.","chicago-de":"Konschake, Leon. 2020. <i>TreeTower</i>. Detmolder Schule für Gestaltung: Technische Hochschule Ostwestfalen-Lippe.","ufg":"<b>Konschake, Leon</b>: TreeTower, Detmolder Schule für Gestaltung 2020."},"publisher":"Technische Hochschule Ostwestfalen-Lippe","date_created":"2026-02-12T11:47:28Z","language":[{"iso":"eng"}],"publication_status":"published","type":"bachelor_thesis","author":[{"first_name":"Leon","id":"84541","last_name":"Konschake","full_name":"Konschake, Leon","orcid":"https://orcid.org/0009-0000-5181-1573"}]}]