---
_id: '10743'
citation:
  ama: Stosch M, ed. <i>igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe 2020</i>. 1st
    ed. Interessengemeinschaft Leichtbau e.V.; 2020.
  apa: Stosch, M. (Ed.). (2020). <i>igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe
    2020</i> (1st ed.). Interessengemeinschaft Leichtbau e.V.
  bjps: '<b>Stosch M (ed.)</b> (2020) <i>igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe
    2020</i>, 1st ed. Herford: Interessengemeinschaft Leichtbau e.V.'
  chicago: 'Stosch, Martin, ed. <i>igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe 2020</i>.
    1st ed. Herford: Interessengemeinschaft Leichtbau e.V., 2020.'
  chicago-de: 'Stosch, Martin, Hrsg. 2020. <i>igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe
    2020</i>. 1. Aufl. Herford: Interessengemeinschaft Leichtbau e.V.'
  din1505-2-1: '<span style="font-variant:small-caps;">Stosch, M.</span> (Hrsg.):
    <i>igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe 2020</i>. 1. Aufl. Herford :
    Interessengemeinschaft Leichtbau e.V., 2020'
  havard: M. Stosch, ed., igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe 2020, 1st
    ed., Interessengemeinschaft Leichtbau e.V., Herford, 2020.
  ieee: 'M. Stosch, Ed., <i>igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe 2020</i>,
    1st ed. Herford: Interessengemeinschaft Leichtbau e.V., 2020.'
  mla: Stosch, Martin, editor. <i>igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe 2020</i>.
    1st ed., Interessengemeinschaft Leichtbau e.V., 2020.
  short: M. Stosch, ed., igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe 2020, 1st ed.,
    Interessengemeinschaft Leichtbau e.V., Herford, 2020.
  ufg: '<i>Stosch, Martin</i>: igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe 2020,
    Herford <sup>1</sup>2020.'
  van: 'Stosch M, editor. igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe 2020. 1st
    ed. Herford: Interessengemeinschaft Leichtbau e.V.; 2020. 142 p.'
date_created: 2023-11-15T10:19:50Z
date_updated: 2023-11-17T13:46:49Z
department:
- _id: DEP7021
edition: '1'
editor:
- first_name: Martin
  full_name: Stosch, Martin
  id: '14633'
  last_name: Stosch
language:
- iso: ger
page: '142'
place: Herford
publication_status: published
publisher: Interessengemeinschaft Leichtbau e.V.
status: public
title: igeL-Leichtbau-Handbuch / ZOW-Preview-Ausgabe 2020
type: book_editor
user_id: '83778'
year: '2020'
...
---
_id: '10776'
application_date: 2019-01-11
application_number: ' 102019100681'
author:
- first_name: Martin
  full_name: Stosch, Martin
  id: '14633'
  last_name: Stosch
- first_name: Peter
  full_name: Kettler, Peter
  last_name: Kettler
citation:
  ama: Stosch M, Kettler P. Leichtbauplatte. (DE102019100681A1). Published online
    2020.
  apa: Stosch, M., &#38; Kettler, P. (2020). <i>Leichtbauplatte. (DE102019100681A1)</i>.
  bjps: <b>Stosch M and Kettler P</b> (2020) Leichtbauplatte. (DE102019100681A1).
  chicago: Stosch, Martin, and Peter Kettler. “Leichtbauplatte. (DE102019100681A1),”
    2020.
  chicago-de: Stosch, Martin und Peter Kettler. 2020. Leichtbauplatte. (DE102019100681A1).
  din1505-2-1: '<span style="font-variant:small-caps;">Stosch, Martin</span> ; <span
    style="font-variant:small-caps;">Kettler, Peter</span>: Leichtbauplatte. (DE102019100681A1)
    (2020)'
  havard: M. Stosch, P. Kettler, Leichtbauplatte. (DE102019100681A1), (2020).
  ieee: M. Stosch and P. Kettler, “Leichtbauplatte. (DE102019100681A1).” 2020.
  mla: Stosch, Martin, and Peter Kettler. <i>Leichtbauplatte. (DE102019100681A1)</i>.
    2020.
  short: M. Stosch, P. Kettler, (2020).
  ufg: '<b>Stosch, Martin/Kettler, Peter</b>: Leichtbauplatte. (DE102019100681A1),
    o. O. 2020.'
  van: Stosch M, Kettler P. Leichtbauplatte. (DE102019100681A1). 2020.
date_created: 2023-11-15T18:20:11Z
date_updated: 2023-11-17T12:56:55Z
department:
- _id: DEP7021
ipc: B27N 3/18
ipn: DE102019100681A1
page: '12'
publication_date: 2020-07-16
status: public
title: Leichtbauplatte. (DE102019100681A1)
type: patent
user_id: '83778'
year: '2020'
...
---
_id: '10778'
application_date: 2020-01-09
application_number: '2020050464'
author:
- first_name: Martin
  full_name: Stosch, Martin
  id: '14633'
  last_name: Stosch
- first_name: Peter
  full_name: Kettler, Peter
  last_name: Kettler
citation:
  ama: Stosch M, Kettler P. Leichtbauplatte. (WO002020144296A3). Published online
    2020.
  apa: Stosch, M., &#38; Kettler, P. (2020). <i>Leichtbauplatte. (WO002020144296A3)</i>.
  bjps: <b>Stosch M and Kettler P</b> (2020) Leichtbauplatte. (WO002020144296A3).
  chicago: Stosch, Martin, and Peter Kettler. “Leichtbauplatte. (WO002020144296A3),”
    2020.
  chicago-de: Stosch, Martin und Peter Kettler. 2020. Leichtbauplatte. (WO002020144296A3).
  din1505-2-1: '<span style="font-variant:small-caps;">Stosch, Martin</span> ; <span
    style="font-variant:small-caps;">Kettler, Peter</span>: Leichtbauplatte. (WO002020144296A3)
    (2020)'
  havard: M. Stosch, P. Kettler, Leichtbauplatte. (WO002020144296A3), (2020).
  ieee: M. Stosch and P. Kettler, “Leichtbauplatte. (WO002020144296A3).” 2020.
  mla: Stosch, Martin, and Peter Kettler. <i>Leichtbauplatte. (WO002020144296A3)</i>.
    2020.
  short: M. Stosch, P. Kettler, (2020).
  ufg: '<b>Stosch, Martin/Kettler, Peter</b>: Leichtbauplatte. (WO002020144296A3),
    o. O. 2020.'
  van: Stosch M, Kettler P. Leichtbauplatte. (WO002020144296A3). 2020.
date_created: 2023-11-15T18:38:36Z
date_updated: 2023-11-17T12:58:37Z
department:
- _id: DEP7021
ipc: B27N 3/00
ipn: WO002020144296A3
page: '11'
publication_date: 2020-10-15
status: public
title: Leichtbauplatte. (WO002020144296A3)
type: patent
user_id: '83778'
year: '2020'
...
---
_id: '10779'
author:
- first_name: Martin
  full_name: Stosch, Martin
  id: '14633'
  last_name: Stosch
citation:
  ama: Stosch M. <i>Smart Wood – Smart Wood Factory.</i>; 2020.
  apa: 'Stosch, M. (2020). <i>Smart Wood – Smart Wood Factory.</i> Workshop: Chancen
    der Urbanisierung II – Wohnen mit Holz (proHolz NRW: Holz. Mehr als ein Rohstoff.),
    Lemgo (Schloss Brake).'
  bjps: <b>Stosch M</b> (2020) <i>Smart Wood – Smart Wood Factory.</i> .
  chicago: Stosch, Martin. <i>Smart Wood – Smart Wood Factory.</i>, 2020.
  chicago-de: Stosch, Martin. 2020. <i>Smart Wood – Smart Wood Factory.</i>
  din1505-2-1: '<span style="font-variant:small-caps;">Stosch, Martin</span>: <i>Smart
    Wood – Smart Wood Factory.</i>, 2020'
  havard: M. Stosch, Smart Wood – Smart Wood Factory., 2020.
  ieee: M. Stosch, <i>Smart Wood – Smart Wood Factory.</i> 2020.
  mla: Stosch, Martin. <i>Smart Wood – Smart Wood Factory.</i> 2020.
  short: M. Stosch, Smart Wood – Smart Wood Factory., 2020.
  ufg: '<b>Stosch, Martin</b>: Smart Wood – Smart Wood Factory., o. O. 2020.'
  van: Stosch M. Smart Wood – Smart Wood Factory. 2020. 64 Vortragsfolien.
conference:
  end_date: 2020-09-09
  location: Lemgo (Schloss Brake)
  name: 'Workshop: Chancen der Urbanisierung II – Wohnen mit Holz (proHolz NRW: Holz.
    Mehr als ein Rohstoff.)'
  start_date: 2020-09-09
date_created: 2023-11-15T18:58:05Z
date_updated: 2023-11-17T12:56:09Z
department:
- _id: DEP7021
language:
- iso: ger
page: 64 Vortragsfolien
publication_status: published
status: public
title: Smart Wood – Smart Wood Factory.
type: conference_speech
user_id: '83778'
year: '2020'
...
---
_id: '9764'
author:
- first_name: Dominik
  full_name: Ropers, Dominik
  last_name: Ropers
- first_name: Boris
  full_name: Stemmer, Boris
  id: '64889'
  last_name: Stemmer
- first_name: Birgit
  full_name: Steffen-Waschek, Birgit
  last_name: Steffen-Waschek
- first_name: Bernd
  full_name: Milde, Bernd
  last_name: Milde
citation:
  ama: 'Ropers D, Stemmer B, Steffen-Waschek B, Milde B. <i>Entwicklung eines zukunfts-
    und querschnittsorientierten Planungsinstruments durch Neuaufstellung der Landschaftspläne
    im Kreis Lippe: Vorstudie: Abschlussbericht</i>. Technische Hochschule Ostwestfalen-Lippe'
  apa: 'Ropers, D., Stemmer, B., Steffen-Waschek, B., &#38; Milde, B. (n.d.). <i>Entwicklung
    eines zukunfts- und querschnittsorientierten Planungsinstruments durch Neuaufstellung
    der Landschaftspläne im Kreis Lippe: Vorstudie: Abschlussbericht</i>. Technische
    Hochschule Ostwestfalen-Lippe.'
  bjps: '<b>Ropers D <i>et al.</i></b> (n.d.) <i>Entwicklung eines zukunfts- und querschnittsorientierten
    Planungsinstruments durch Neuaufstellung der Landschaftspläne im Kreis Lippe:
    Vorstudie: Abschlussbericht</i>. Höxter: Technische Hochschule Ostwestfalen-Lippe.'
  chicago: 'Ropers, Dominik, Boris Stemmer, Birgit Steffen-Waschek, and Bernd Milde.
    <i>Entwicklung eines zukunfts- und querschnittsorientierten Planungsinstruments
    durch Neuaufstellung der Landschaftspläne im Kreis Lippe: Vorstudie: Abschlussbericht</i>.
    Höxter: Technische Hochschule Ostwestfalen-Lippe, n.d.'
  chicago-de: 'Ropers, Dominik, Boris Stemmer, Birgit Steffen-Waschek und Bernd Milde.
    <i>Entwicklung eines zukunfts- und querschnittsorientierten Planungsinstruments
    durch Neuaufstellung der Landschaftspläne im Kreis Lippe: Vorstudie: Abschlussbericht</i>.
    Höxter: Technische Hochschule Ostwestfalen-Lippe.'
  din1505-2-1: '<span style="font-variant:small-caps;">Ropers, Dominik</span> ; <span
    style="font-variant:small-caps;">Stemmer, Boris</span> ; <span style="font-variant:small-caps;">Steffen-Waschek,
    Birgit</span> ; <span style="font-variant:small-caps;">Milde, Bernd</span>: <i>Entwicklung
    eines zukunfts- und querschnittsorientierten Planungsinstruments durch Neuaufstellung
    der Landschaftspläne im Kreis Lippe: Vorstudie: Abschlussbericht</i>. Höxter :
    Technische Hochschule Ostwestfalen-Lippe'
  havard: 'D. Ropers, B. Stemmer, B. Steffen-Waschek, B. Milde, Entwicklung eines
    zukunfts- und querschnittsorientierten Planungsinstruments durch Neuaufstellung
    der Landschaftspläne im Kreis Lippe: Vorstudie: Abschlussbericht, Technische Hochschule
    Ostwestfalen-Lippe, Höxter, n.d.'
  ieee: 'D. Ropers, B. Stemmer, B. Steffen-Waschek, and B. Milde, <i>Entwicklung eines
    zukunfts- und querschnittsorientierten Planungsinstruments durch Neuaufstellung
    der Landschaftspläne im Kreis Lippe: Vorstudie: Abschlussbericht</i>. Höxter:
    Technische Hochschule Ostwestfalen-Lippe.'
  mla: 'Ropers, Dominik, et al. <i>Entwicklung eines zukunfts- und querschnittsorientierten
    Planungsinstruments durch Neuaufstellung der Landschaftspläne im Kreis Lippe:
    Vorstudie: Abschlussbericht</i>. Technische Hochschule Ostwestfalen-Lippe.'
  short: 'D. Ropers, B. Stemmer, B. Steffen-Waschek, B. Milde, Entwicklung eines zukunfts-
    und querschnittsorientierten Planungsinstruments durch Neuaufstellung der Landschaftspläne
    im Kreis Lippe: Vorstudie: Abschlussbericht, Technische Hochschule Ostwestfalen-Lippe,
    Höxter, n.d.'
  ufg: '<b>Ropers, Dominik u. a.</b>: Entwicklung eines zukunfts- und querschnittsorientierten
    Planungsinstruments durch Neuaufstellung der Landschaftspläne im Kreis Lippe:
    Vorstudie: Abschlussbericht, Höxter o. J.'
  van: 'Ropers D, Stemmer B, Steffen-Waschek B, Milde B. Entwicklung eines zukunfts-
    und querschnittsorientierten Planungsinstruments durch Neuaufstellung der Landschaftspläne
    im Kreis Lippe: Vorstudie: Abschlussbericht. Höxter: Technische Hochschule Ostwestfalen-Lippe;'
date_created: 2023-04-24T09:10:24Z
date_updated: 2024-12-16T13:10:40Z
department:
- _id: DEP9013
language:
- iso: ger
place: Höxter
publication_status: unpublished
publisher: Technische Hochschule Ostwestfalen-Lippe
status: public
title: 'Entwicklung eines zukunfts- und querschnittsorientierten Planungsinstruments
  durch Neuaufstellung der Landschaftspläne im Kreis Lippe: Vorstudie: Abschlussbericht'
type: report_science
user_id: '83781'
year: '2020'
...
---
_id: '9765'
author:
- first_name: Ulrich
  full_name: Riedl, Ulrich
  id: '22009'
  last_name: Riedl
- first_name: Boris
  full_name: Stemmer, Boris
  id: '64889'
  last_name: Stemmer
- first_name: Sven
  full_name: Philipper, Sven
  last_name: Philipper
- first_name: Wolfgang
  full_name: Peters, Wolfgang
  last_name: Peters
- first_name: Sven
  full_name: Schicketanz, Sven
  last_name: Schicketanz
- first_name: Miron
  full_name: Thylmann, Miron
  last_name: Thylmann
- first_name: Carsten
  full_name: Pape, Carsten
  last_name: Pape
- first_name: Philip
  full_name: Gauglitz, Philip
  last_name: Gauglitz
- first_name: Jochen
  full_name: Mülder, Jochen
  last_name: Mülder
- first_name: Christian
  full_name: Westarp, Christian
  last_name: Westarp
- first_name: Nicola
  full_name: Moczek, Nicola
  last_name: Moczek
citation:
  ama: 'Riedl U, Stemmer B, Philipper S, et al. <i>Szenarien für den Ausbau der erneuerbaren
    Energien aus Naturschutzsicht: in Vorbereitung: FKZ 3515 82 2900 UFOPLAN 2018</i>.
    Vol 570. Bundesamt für Naturschutz; 2020. doi:<a href="https://doi.org/10.19217/skr570
    ">10.19217/skr570 </a>'
  apa: 'Riedl, U., Stemmer, B., Philipper, S., Peters, W., Schicketanz, S., Thylmann,
    M., Pape, C., Gauglitz, P., Mülder, J., Westarp, C., &#38; Moczek, N. (2020).
    <i>Szenarien für den Ausbau der erneuerbaren Energien aus Naturschutzsicht: in
    Vorbereitung: FKZ 3515 82 2900 UFOPLAN 2018</i> (Vol. 570). Bundesamt für Naturschutz.
    <a href="https://doi.org/10.19217/skr570 ">https://doi.org/10.19217/skr570 </a>'
  bjps: '<b>Riedl U <i>et al.</i></b> (2020) <i>Szenarien für den Ausbau der erneuerbaren
    Energien aus Naturschutzsicht: in Vorbereitung: FKZ 3515 82 2900 UFOPLAN 2018</i>.
    Bonn: Bundesamt für Naturschutz.'
  chicago: 'Riedl, Ulrich, Boris Stemmer, Sven Philipper, Wolfgang Peters, Sven Schicketanz,
    Miron Thylmann, Carsten Pape, et al. <i>Szenarien für den Ausbau der erneuerbaren
    Energien aus Naturschutzsicht: in Vorbereitung: FKZ 3515 82 2900 UFOPLAN 2018</i>.
    Vol. 570. BfN-Skripten. Bonn: Bundesamt für Naturschutz, 2020. <a href="https://doi.org/10.19217/skr570
    ">https://doi.org/10.19217/skr570 </a>.'
  chicago-de: 'Riedl, Ulrich, Boris Stemmer, Sven Philipper, Wolfgang Peters, Sven
    Schicketanz, Miron Thylmann, Carsten Pape, u. a. 2020. <i>Szenarien für den Ausbau
    der erneuerbaren Energien aus Naturschutzsicht: in Vorbereitung: FKZ 3515 82 2900
    UFOPLAN 2018</i>. Bd. 570. BfN-Skripten. Bonn: Bundesamt für Naturschutz. doi:<a
    href="https://doi.org/10.19217/skr570 ">10.19217/skr570 </a>, .'
  din1505-2-1: '<span style="font-variant:small-caps;"><span style="font-variant:small-caps;">Riedl,
    Ulrich</span> ; <span style="font-variant:small-caps;">Stemmer, Boris</span> ;
    <span style="font-variant:small-caps;">Philipper, Sven</span> ; <span style="font-variant:small-caps;">Peters,
    Wolfgang</span> ; <span style="font-variant:small-caps;">Schicketanz, Sven</span>
    ; <span style="font-variant:small-caps;">Thylmann, Miron</span> ; <span style="font-variant:small-caps;">Pape,
    Carsten</span> ; <span style="font-variant:small-caps;">Gauglitz, Philip</span>
    ; u. a.</span>: <i>Szenarien für den Ausbau der erneuerbaren Energien aus Naturschutzsicht:
    in Vorbereitung: FKZ 3515 82 2900 UFOPLAN 2018</i>, <i>BfN-Skripten</i>. Bd. 570.
    Bonn : Bundesamt für Naturschutz, 2020'
  havard: 'U. Riedl, B. Stemmer, S. Philipper, W. Peters, S. Schicketanz, M. Thylmann,
    C. Pape, P. Gauglitz, J. Mülder, C. Westarp, N. Moczek, Szenarien für den Ausbau
    der erneuerbaren Energien aus Naturschutzsicht: in Vorbereitung: FKZ 3515 82 2900
    UFOPLAN 2018, Bundesamt für Naturschutz, Bonn, 2020.'
  ieee: 'U. Riedl <i>et al.</i>, <i>Szenarien für den Ausbau der erneuerbaren Energien
    aus Naturschutzsicht: in Vorbereitung: FKZ 3515 82 2900 UFOPLAN 2018</i>, vol.
    570. Bonn: Bundesamt für Naturschutz, 2020. doi: <a href="https://doi.org/10.19217/skr570
    ">10.19217/skr570 </a>.'
  mla: 'Riedl, Ulrich, et al. <i>Szenarien für den Ausbau der erneuerbaren Energien
    aus Naturschutzsicht: in Vorbereitung: FKZ 3515 82 2900 UFOPLAN 2018</i>. Bundesamt
    für Naturschutz, 2020, <a href="https://doi.org/10.19217/skr570 ">https://doi.org/10.19217/skr570
    </a>.'
  short: 'U. Riedl, B. Stemmer, S. Philipper, W. Peters, S. Schicketanz, M. Thylmann,
    C. Pape, P. Gauglitz, J. Mülder, C. Westarp, N. Moczek, Szenarien für den Ausbau
    der erneuerbaren Energien aus Naturschutzsicht: in Vorbereitung: FKZ 3515 82 2900
    UFOPLAN 2018, Bundesamt für Naturschutz, Bonn, 2020.'
  ufg: '<b>Riedl, Ulrich u. a.</b>: Szenarien für den Ausbau der erneuerbaren Energien
    aus Naturschutzsicht: in Vorbereitung: FKZ 3515 82 2900 UFOPLAN 2018, Bd. 570,
    Bonn 2020 (BfN-Skripten).'
  van: 'Riedl U, Stemmer B, Philipper S, Peters W, Schicketanz S, Thylmann M, et al.
    Szenarien für den Ausbau der erneuerbaren Energien aus Naturschutzsicht: in Vorbereitung:
    FKZ 3515 82 2900 UFOPLAN 2018. Bonn: Bundesamt für Naturschutz; 2020. (BfN-Skripten;
    vol. 570).'
date_created: 2023-04-24T09:10:25Z
date_updated: 2023-05-12T06:37:02Z
department:
- _id: DEP9013
doi: '10.19217/skr570 '
intvolume: '       570'
language:
- iso: ger
main_file_link:
- open_access: '1'
  url: https://www.bfn.de/sites/default/files/BfN/service/Dokumente/skripten/skript570.pdf
oa: '1'
place: Bonn
publication_identifier:
  isbn:
  - 978-3-89624-331-7
publication_status: published
publisher: Bundesamt für Naturschutz
series_title: BfN-Skripten
status: public
title: 'Szenarien für den Ausbau der erneuerbaren Energien aus Naturschutzsicht: in
  Vorbereitung: FKZ 3515 82 2900 UFOPLAN 2018'
type: book
user_id: '15514'
volume: 570
year: '2020'
...
---
_id: '12231'
abstract:
- lang: eng
  text: In temperate lakes, it is generally assumed that light rather than temperature
    constrains phytoplankton growth in winter. Rapid winter warming and increasing
    observations of winter blooms warrant more investigation of these controls. We
    investigated the mechanisms regulating a massive winter diatom bloom in a temperate
    lake. High frequency data and process-based lake modeling demonstrated that phytoplankton
    growth in winter was dually controlled by light and temperature, rather than by
    light alone. Water temperature played a further indirect role in initiating the
    bloom through ice-thaw, which increased light exposure. The bloom was ultimately
    terminated by silicon limitation and sedimentation. These mechanisms differ from
    those typically responsible for spring diatom blooms and contributed to the high
    peak biomass. Our findings show that phytoplankton growth in winter is more sensitive
    to temperature, and consequently to climate change, than previously assumed. This
    has implications for nutrient cycling and seasonal succession of lake phytoplankton
    communities. The present study exemplifies the strength in integrating data analysis
    with different temporal resolutions and lake modeling. The new lake ecological
    model serves as an effective tool in analyzing and predicting winter phytoplankton
    dynamics for temperate lakes.
article_number: '116681'
author:
- first_name: Xiangzhen
  full_name: Kong, Xiangzhen
  last_name: Kong
- first_name: Michael
  full_name: Seewald, Michael
  last_name: Seewald
- first_name: Tallent
  full_name: Dadi, Tallent
  last_name: Dadi
- first_name: Kurt
  full_name: Friese, Kurt
  last_name: Friese
- first_name: Chenxi
  full_name: Mi, Chenxi
  last_name: Mi
- first_name: Bertram
  full_name: Boehrer, Bertram
  last_name: Boehrer
- first_name: Martin
  full_name: Schultze, Martin
  last_name: Schultze
- first_name: Karsten
  full_name: Rinke, Karsten
  last_name: Rinke
- first_name: Tom
  full_name: Shatwell, Tom
  id: '86424'
  last_name: Shatwell
  orcid: 0000-0002-4520-7916
citation:
  ama: 'Kong X, Seewald M, Dadi T, et al. Unravelling winter diatom blooms in temperate
    lakes using high frequency data and ecological modeling. <i>Water research : a
    journal of the International Water Association</i>. 2020;190. doi:<a href="https://doi.org/10.1016/j.watres.2020.116681">10.1016/j.watres.2020.116681</a>'
  apa: 'Kong, X., Seewald, M., Dadi, T., Friese, K., Mi, C., Boehrer, B., Schultze,
    M., Rinke, K., &#38; Shatwell, T. (2020). Unravelling winter diatom blooms in
    temperate lakes using high frequency data and ecological modeling. <i>Water Research :
    A Journal of the International Water Association</i>, <i>190</i>, Article 116681.
    <a href="https://doi.org/10.1016/j.watres.2020.116681">https://doi.org/10.1016/j.watres.2020.116681</a>'
  bjps: '<b>Kong X <i>et al.</i></b> (2020) Unravelling Winter Diatom Blooms in Temperate
    Lakes Using High Frequency Data and Ecological Modeling. <i>Water research : a
    journal of the International Water Association</i> <b>190</b>.'
  chicago: 'Kong, Xiangzhen, Michael Seewald, Tallent Dadi, Kurt Friese, Chenxi Mi,
    Bertram Boehrer, Martin Schultze, Karsten Rinke, and Tom Shatwell. “Unravelling
    Winter Diatom Blooms in Temperate Lakes Using High Frequency Data and Ecological
    Modeling.” <i>Water Research : A Journal of the International Water Association</i>
    190 (2020). <a href="https://doi.org/10.1016/j.watres.2020.116681">https://doi.org/10.1016/j.watres.2020.116681</a>.'
  chicago-de: 'Kong, Xiangzhen, Michael Seewald, Tallent Dadi, Kurt Friese, Chenxi
    Mi, Bertram Boehrer, Martin Schultze, Karsten Rinke und Tom Shatwell. 2020. Unravelling
    winter diatom blooms in temperate lakes using high frequency data and ecological
    modeling. <i>Water research : a journal of the International Water Association</i>
    190. doi:<a href="https://doi.org/10.1016/j.watres.2020.116681">10.1016/j.watres.2020.116681</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;"><span style="font-variant:small-caps;">Kong,
    Xiangzhen</span> ; <span style="font-variant:small-caps;">Seewald, Michael</span>
    ; <span style="font-variant:small-caps;">Dadi, Tallent</span> ; <span style="font-variant:small-caps;">Friese,
    Kurt</span> ; <span style="font-variant:small-caps;">Mi, Chenxi</span> ; <span
    style="font-variant:small-caps;">Boehrer, Bertram</span> ; <span style="font-variant:small-caps;">Schultze,
    Martin</span> ; <span style="font-variant:small-caps;">Rinke, Karsten</span> ;
    u. a.</span>: Unravelling winter diatom blooms in temperate lakes using high frequency
    data and ecological modeling. In: <i>Water research : a journal of the International
    Water Association</i> Bd. 190. Amsterdam, Elsevier BV (2020)'
  havard: 'X. Kong, M. Seewald, T. Dadi, K. Friese, C. Mi, B. Boehrer, M. Schultze,
    K. Rinke, T. Shatwell, Unravelling winter diatom blooms in temperate lakes using
    high frequency data and ecological modeling, Water Research : A Journal of the
    International Water Association. 190 (2020).'
  ieee: 'X. Kong <i>et al.</i>, “Unravelling winter diatom blooms in temperate lakes
    using high frequency data and ecological modeling,” <i>Water research : a journal
    of the International Water Association</i>, vol. 190, Art. no. 116681, 2020, doi:
    <a href="https://doi.org/10.1016/j.watres.2020.116681">10.1016/j.watres.2020.116681</a>.'
  mla: 'Kong, Xiangzhen, et al. “Unravelling Winter Diatom Blooms in Temperate Lakes
    Using High Frequency Data and Ecological Modeling.” <i>Water Research : A Journal
    of the International Water Association</i>, vol. 190, 116681, 2020, <a href="https://doi.org/10.1016/j.watres.2020.116681">https://doi.org/10.1016/j.watres.2020.116681</a>.'
  short: 'X. Kong, M. Seewald, T. Dadi, K. Friese, C. Mi, B. Boehrer, M. Schultze,
    K. Rinke, T. Shatwell, Water Research : A Journal of the International Water Association
    190 (2020).'
  ufg: '<b>Kong, Xiangzhen u. a.</b>: Unravelling winter diatom blooms in temperate
    lakes using high frequency data and ecological modeling, in: <i>Water research :
    a journal of the International Water Association</i> 190 (2020).'
  van: 'Kong X, Seewald M, Dadi T, Friese K, Mi C, Boehrer B, et al. Unravelling winter
    diatom blooms in temperate lakes using high frequency data and ecological modeling.
    Water research : a journal of the International Water Association. 2020;190.'
date_created: 2024-12-08T20:19:54Z
date_updated: 2024-12-09T11:24:12Z
department:
- _id: DEP8022
doi: 10.1016/j.watres.2020.116681
extern: '1'
intvolume: '       190'
keyword:
- Winter diatom bloom
- High frequency monitoring
- Lake modeling
- Light limitation
- Temperature
language:
- iso: eng
main_file_link:
- url: https://doi.org/10.1016/j.watres.2020.116681
place: Amsterdam
publication: 'Water research : a journal of the International Water Association'
publication_identifier:
  eissn:
  - 1879-2448
  issn:
  - 0043-1354
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
status: public
title: Unravelling winter diatom blooms in temperate lakes using high frequency data
  and ecological modeling
type: scientific_journal_article
user_id: '83781'
volume: 190
year: '2020'
...
---
_id: '12233'
abstract:
- lang: eng
  text: The thermal structure in reservoirs affects the development of aquatic ecosystems,
    and can be substantially influenced by climate change and management strategies.
    We applied a two-dimensional hydrodynamic model to explore the response of the
    thermal structure in Germany's largest drinking water reservoir, Rappbode Reservoir,
    to future climate projections and different water withdrawal strategies. We used
    projections for representative concentration pathways (RCP) 2.6, 6.0 and 8.5 from
    an ensemble of 4 different global climate models. Simulation results showed that
    epilimnetic water temperatures in the reservoir strongly increased under all three
    climate scenarios. Hypolimnetic temperatures remained rather constant under RCP
    2.6 and RCP 6.0 but increased markedly under RCP 8.5. Under the intense warming
    in RCP 8.5, hypolimnion temperatures were projected to rise from 5 °C to 8 °C
    by the end of the century. Stratification in the reservoir was projected to be
    more stable under RCP 6.0 and RCP 8.5, but did not show significant changes under
    RCP 2.6. Similar results were found with respect to the light intensity within
    the mixed-layer. Moreover, the results suggested that surface withdrawal can be
    an effective adaptation strategy under strong climate warming (RCP 8.5) to reduce
    surface warming and avoid hypolimnetic warming. This study documents how global
    scale climate projections can be translated into site-specific climate impacts
    to derive adaptation strategies for reservoir operation. Moreover, our results
    illustrate that the most intense warming scenario, i.e. RCP 8.5, demands far-reaching
    climate adaptation while the mitigation scenario (RCP 2.6) does not require adaptation
    of reservoir management before 2100.
article_number: '141366'
author:
- first_name: Chenxi
  full_name: Mi, Chenxi
  last_name: Mi
- first_name: Tom
  full_name: Shatwell, Tom
  id: '86424'
  last_name: Shatwell
  orcid: 0000-0002-4520-7916
- first_name: Jun
  full_name: Ma, Jun
  last_name: Ma
- first_name: Yaqian
  full_name: Xu, Yaqian
  last_name: Xu
- first_name: Fangli
  full_name: Su, Fangli
  last_name: Su
- first_name: Karsten
  full_name: Rinke, Karsten
  last_name: Rinke
citation:
  ama: 'Mi C, Shatwell T, Ma J, Xu Y, Su F, Rinke K. Ensemble warming projections
    in Germany’s largest drinking water reservoir and potential adaptation strategies.
    <i>The science of the total environment : an international journal for scientific
    research into the environment and its relationship with man</i>. 2020;748(12).
    doi:<a href="https://doi.org/10.1016/j.scitotenv.2020.141366">10.1016/j.scitotenv.2020.141366</a>'
  apa: 'Mi, C., Shatwell, T., Ma, J., Xu, Y., Su, F., &#38; Rinke, K. (2020). Ensemble
    warming projections in Germany’s largest drinking water reservoir and potential
    adaptation strategies. <i>The Science of the Total Environment : An International
    Journal for Scientific Research into the Environment and Its Relationship with
    Man</i>, <i>748</i>(12), Article 141366. <a href="https://doi.org/10.1016/j.scitotenv.2020.141366">https://doi.org/10.1016/j.scitotenv.2020.141366</a>'
  bjps: '<b>Mi C <i>et al.</i></b> (2020) Ensemble Warming Projections in Germany’s
    Largest Drinking Water Reservoir and Potential Adaptation Strategies. <i>The science
    of the total environment : an international journal for scientific research into
    the environment and its relationship with man</i> <b>748</b>.'
  chicago: 'Mi, Chenxi, Tom Shatwell, Jun Ma, Yaqian Xu, Fangli Su, and Karsten Rinke.
    “Ensemble Warming Projections in Germany’s Largest Drinking Water Reservoir and
    Potential Adaptation Strategies.” <i>The Science of the Total Environment : An
    International Journal for Scientific Research into the Environment and Its Relationship
    with Man</i> 748, no. 12 (2020). <a href="https://doi.org/10.1016/j.scitotenv.2020.141366">https://doi.org/10.1016/j.scitotenv.2020.141366</a>.'
  chicago-de: 'Mi, Chenxi, Tom Shatwell, Jun Ma, Yaqian Xu, Fangli Su und Karsten
    Rinke. 2020. Ensemble warming projections in Germany’s largest drinking water
    reservoir and potential adaptation strategies. <i>The science of the total environment :
    an international journal for scientific research into the environment and its
    relationship with man</i> 748, Nr. 12. doi:<a href="https://doi.org/10.1016/j.scitotenv.2020.141366">10.1016/j.scitotenv.2020.141366</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Mi, Chenxi</span> ; <span style="font-variant:small-caps;">Shatwell,
    Tom</span> ; <span style="font-variant:small-caps;">Ma, Jun</span> ; <span style="font-variant:small-caps;">Xu,
    Yaqian</span> ; <span style="font-variant:small-caps;">Su, Fangli</span> ; <span
    style="font-variant:small-caps;">Rinke, Karsten</span>: Ensemble warming projections
    in Germany’s largest drinking water reservoir and potential adaptation strategies.
    In: <i>The science of the total environment : an international journal for scientific
    research into the environment and its relationship with man</i> Bd. 748. Amsterdam,
    Elsevier BV (2020), Nr. 12'
  havard: 'C. Mi, T. Shatwell, J. Ma, Y. Xu, F. Su, K. Rinke, Ensemble warming projections
    in Germany’s largest drinking water reservoir and potential adaptation strategies,
    The Science of the Total Environment : An International Journal for Scientific
    Research into the Environment and Its Relationship with Man. 748 (2020).'
  ieee: 'C. Mi, T. Shatwell, J. Ma, Y. Xu, F. Su, and K. Rinke, “Ensemble warming
    projections in Germany’s largest drinking water reservoir and potential adaptation
    strategies,” <i>The science of the total environment : an international journal
    for scientific research into the environment and its relationship with man</i>,
    vol. 748, no. 12, Art. no. 141366, 2020, doi: <a href="https://doi.org/10.1016/j.scitotenv.2020.141366">10.1016/j.scitotenv.2020.141366</a>.'
  mla: 'Mi, Chenxi, et al. “Ensemble Warming Projections in Germany’s Largest Drinking
    Water Reservoir and Potential Adaptation Strategies.” <i>The Science of the Total
    Environment : An International Journal for Scientific Research into the Environment
    and Its Relationship with Man</i>, vol. 748, no. 12, 141366, 2020, <a href="https://doi.org/10.1016/j.scitotenv.2020.141366">https://doi.org/10.1016/j.scitotenv.2020.141366</a>.'
  short: 'C. Mi, T. Shatwell, J. Ma, Y. Xu, F. Su, K. Rinke, The Science of the Total
    Environment : An International Journal for Scientific Research into the Environment
    and Its Relationship with Man 748 (2020).'
  ufg: '<b>Mi, Chenxi u. a.</b>: Ensemble warming projections in Germany’s largest
    drinking water reservoir and potential adaptation strategies, in: <i>The science
    of the total environment : an international journal for scientific research into
    the environment and its relationship with man</i> 748 (2020), H. 12.'
  van: 'Mi C, Shatwell T, Ma J, Xu Y, Su F, Rinke K. Ensemble warming projections
    in Germany’s largest drinking water reservoir and potential adaptation strategies.
    The science of the total environment : an international journal for scientific
    research into the environment and its relationship with man. 2020;748(12).'
date_created: 2024-12-08T20:23:26Z
date_updated: 2024-12-09T11:18:40Z
department:
- _id: DEP8022
doi: 10.1016/j.scitotenv.2020.141366
extern: '1'
intvolume: '       748'
issue: '12'
keyword:
- Rappbode Reservoir
- Thermal structure
- Climate change
- CE-QUAL-W2
- Selective water withdrawal
language:
- iso: eng
main_file_link:
- url: https://doi.org/10.1016/j.scitotenv.2020.141366
place: Amsterdam
publication: 'The science of the total environment : an international journal for
  scientific research into the environment and its relationship with man'
publication_identifier:
  eissn:
  - 1879-1026
  issn:
  - 0048-9697
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
status: public
title: Ensemble warming projections in Germany's largest drinking water reservoir
  and potential adaptation strategies
type: scientific_journal_article
user_id: '83781'
volume: 748
year: '2020'
...
---
_id: '12234'
author:
- first_name: Christopher C. M.
  full_name: Kyba, Christopher C. M.
  last_name: Kyba
- first_name: Jeff
  full_name: Conrad, Jeff
  last_name: Conrad
- first_name: Tom
  full_name: Shatwell, Tom
  id: '86424'
  last_name: Shatwell
  orcid: 0000-0002-4520-7916
citation:
  ama: Kyba CCM, Conrad J, Shatwell T. Lunar illuminated fraction is a poor proxy
    for moonlight exposure. <i>Nature ecology &#38; evolution</i>. 2020;4(3):318-319.
    doi:<a href="https://doi.org/10.1038/s41559-020-1096-7">10.1038/s41559-020-1096-7</a>
  apa: Kyba, C. C. M., Conrad, J., &#38; Shatwell, T. (2020). Lunar illuminated fraction
    is a poor proxy for moonlight exposure. <i>Nature Ecology &#38; Evolution</i>,
    <i>4</i>(3), 318–319. <a href="https://doi.org/10.1038/s41559-020-1096-7">https://doi.org/10.1038/s41559-020-1096-7</a>
  bjps: <b>Kyba CCM, Conrad J and Shatwell T</b> (2020) Lunar Illuminated Fraction
    Is a Poor Proxy for Moonlight Exposure. <i>Nature ecology &#38; evolution</i>
    <b>4</b>, 318–319.
  chicago: 'Kyba, Christopher C. M., Jeff Conrad, and Tom Shatwell. “Lunar Illuminated
    Fraction Is a Poor Proxy for Moonlight Exposure.” <i>Nature Ecology &#38; Evolution</i>
    4, no. 3 (2020): 318–19. <a href="https://doi.org/10.1038/s41559-020-1096-7">https://doi.org/10.1038/s41559-020-1096-7</a>.'
  chicago-de: 'Kyba, Christopher C. M., Jeff Conrad und Tom Shatwell. 2020. Lunar
    illuminated fraction is a poor proxy for moonlight exposure. <i>Nature ecology
    &#38; evolution</i> 4, Nr. 3: 318–319. doi:<a href="https://doi.org/10.1038/s41559-020-1096-7">10.1038/s41559-020-1096-7</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Kyba, Christopher C. M.</span>
    ; <span style="font-variant:small-caps;">Conrad, Jeff</span> ; <span style="font-variant:small-caps;">Shatwell,
    Tom</span>: Lunar illuminated fraction is a poor proxy for moonlight exposure.
    In: <i>Nature ecology &#38; evolution</i> Bd. 4. London, Nature Publishing Group  (2020),
    Nr. 3, S. 318–319'
  havard: C.C.M. Kyba, J. Conrad, T. Shatwell, Lunar illuminated fraction is a poor
    proxy for moonlight exposure, Nature Ecology &#38; Evolution. 4 (2020) 318–319.
  ieee: 'C. C. M. Kyba, J. Conrad, and T. Shatwell, “Lunar illuminated fraction is
    a poor proxy for moonlight exposure,” <i>Nature ecology &#38; evolution</i>, vol.
    4, no. 3, pp. 318–319, 2020, doi: <a href="https://doi.org/10.1038/s41559-020-1096-7">10.1038/s41559-020-1096-7</a>.'
  mla: Kyba, Christopher C. M., et al. “Lunar Illuminated Fraction Is a Poor Proxy
    for Moonlight Exposure.” <i>Nature Ecology &#38; Evolution</i>, vol. 4, no. 3,
    2020, pp. 318–19, <a href="https://doi.org/10.1038/s41559-020-1096-7">https://doi.org/10.1038/s41559-020-1096-7</a>.
  short: C.C.M. Kyba, J. Conrad, T. Shatwell, Nature Ecology &#38; Evolution 4 (2020)
    318–319.
  ufg: '<b>Kyba, Christopher C.M./Conrad, Jeff/Shatwell, Tom</b>: Lunar illuminated
    fraction is a poor proxy for moonlight exposure, in: <i>Nature ecology &#38; evolution</i>
    4 (2020), H. 3,  S. 318–319.'
  van: Kyba CCM, Conrad J, Shatwell T. Lunar illuminated fraction is a poor proxy
    for moonlight exposure. Nature ecology &#38; evolution. 2020;4(3):318–9.
date_created: 2024-12-08T20:24:48Z
date_updated: 2024-12-09T10:42:29Z
department:
- _id: DEP8022
doi: 10.1038/s41559-020-1096-7
extern: '1'
intvolume: '         4'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://doi.org/10.1038/s41559-020-1096-7
page: 318-319
place: London
publication: Nature ecology & evolution
publication_identifier:
  eissn:
  - 2397-334X
publication_status: published
publisher: 'Nature Publishing Group '
quality_controlled: '1'
status: public
title: Lunar illuminated fraction is a poor proxy for moonlight exposure
type: scientific_journal_article
user_id: '83781'
volume: 4
year: '2020'
...
---
_id: '12235'
abstract:
- lang: eng
  text: Metalimnetic oxygen minima are observed in many lakes and reservoirs, but
    the mechanisms behind this phenomena are not well understood. Thus, we simulated
    the metalimnetic oxygen minimum (MOM) in the Rappbode Reservoir with a well-established
    two-dimensional water quality model (CE-QUAL-W2) to systematically quantify the
    chain of events leading to its formation. We used high-resolution measured data
    to calibrate the model, which accurately reproduced the physical (e.g. water level
    and water temperature), biogeochemical (e.g. nutrient and oxygen dynamics) and
    ecological (e.g. algal community dynamics) features of the reservoir, particularly
    the spatial and temporal extent of the MOM. The results indicated that around
    60% of the total oxygen consumption rate in the MOM layer originated from benthic
    processes whereas the remainder originated from pelagic processes. The occurrence
    of the cyanobacterium Planktothrix rubescens in the metalimnion delayed and slightly
    weakened the MOM through photosynthesis, although its decaying biomass ultimately
    induced the MOM. Our research also confirmed the decisive role of water temperature
    in the formation of the MOM since the water temperatures, and thus benthic and
    pelagic oxygen consumption rates, were higher in the metalimnion than in the hypolimnion.
    Our model is not only providing novel conclusions about the drivers of MOM development
    and their quantitative contributions, it is also a new tool for understanding
    and predicting ecological and biogeochemical water quality dynamics.
article_number: '115701'
author:
- first_name: Chenxi
  full_name: Mi, Chenxi
  last_name: Mi
- first_name: Tom
  full_name: Shatwell, Tom
  id: '86424'
  last_name: Shatwell
  orcid: 0000-0002-4520-7916
- first_name: Jun
  full_name: Ma, Jun
  last_name: Ma
- first_name: Valerie Carolin
  full_name: Wentzky, Valerie Carolin
  last_name: Wentzky
- first_name: Bertram
  full_name: Boehrer, Bertram
  last_name: Boehrer
- first_name: Yaqian
  full_name: Xu, Yaqian
  last_name: Xu
- first_name: Karsten
  full_name: Rinke, Karsten
  last_name: Rinke
citation:
  ama: 'Mi C, Shatwell T, Ma J, et al. The formation of a metalimnetic oxygen minimum
    exemplifies how ecosystem dynamics shape biogeochemical processes: A modelling
    study. <i>Water research : a journal of the International Water Association</i>.
    2020;175(5). doi:<a href="https://doi.org/10.1016/j.watres.2020.115701">10.1016/j.watres.2020.115701</a>'
  apa: 'Mi, C., Shatwell, T., Ma, J., Wentzky, V. C., Boehrer, B., Xu, Y., &#38; Rinke,
    K. (2020). The formation of a metalimnetic oxygen minimum exemplifies how ecosystem
    dynamics shape biogeochemical processes: A modelling study. <i>Water Research :
    A Journal of the International Water Association</i>, <i>175</i>(5), Article 115701.
    <a href="https://doi.org/10.1016/j.watres.2020.115701">https://doi.org/10.1016/j.watres.2020.115701</a>'
  bjps: '<b>Mi C <i>et al.</i></b> (2020) The Formation of a Metalimnetic Oxygen Minimum
    Exemplifies How Ecosystem Dynamics Shape Biogeochemical Processes: A Modelling
    Study. <i>Water research : a journal of the International Water Association</i>
    <b>175</b>.'
  chicago: 'Mi, Chenxi, Tom Shatwell, Jun Ma, Valerie Carolin Wentzky, Bertram Boehrer,
    Yaqian Xu, and Karsten Rinke. “The Formation of a Metalimnetic Oxygen Minimum
    Exemplifies How Ecosystem Dynamics Shape Biogeochemical Processes: A Modelling
    Study.” <i>Water Research : A Journal of the International Water Association</i>
    175, no. 5 (2020). <a href="https://doi.org/10.1016/j.watres.2020.115701">https://doi.org/10.1016/j.watres.2020.115701</a>.'
  chicago-de: 'Mi, Chenxi, Tom Shatwell, Jun Ma, Valerie Carolin Wentzky, Bertram
    Boehrer, Yaqian Xu und Karsten Rinke. 2020. The formation of a metalimnetic oxygen
    minimum exemplifies how ecosystem dynamics shape biogeochemical processes: A modelling
    study. <i>Water research : a journal of the International Water Association</i>
    175, Nr. 5. doi:<a href="https://doi.org/10.1016/j.watres.2020.115701">10.1016/j.watres.2020.115701</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Mi, Chenxi</span> ; <span style="font-variant:small-caps;">Shatwell,
    Tom</span> ; <span style="font-variant:small-caps;">Ma, Jun</span> ; <span style="font-variant:small-caps;">Wentzky,
    Valerie Carolin</span> ; <span style="font-variant:small-caps;">Boehrer, Bertram</span>
    ; <span style="font-variant:small-caps;">Xu, Yaqian</span> ; <span style="font-variant:small-caps;">Rinke,
    Karsten</span>: The formation of a metalimnetic oxygen minimum exemplifies how
    ecosystem dynamics shape biogeochemical processes: A modelling study. In: <i>Water
    research : a journal of the International Water Association</i> Bd. 175. Amsterdam,
    Elsevier BV (2020), Nr. 5'
  havard: 'C. Mi, T. Shatwell, J. Ma, V.C. Wentzky, B. Boehrer, Y. Xu, K. Rinke, The
    formation of a metalimnetic oxygen minimum exemplifies how ecosystem dynamics
    shape biogeochemical processes: A modelling study, Water Research : A Journal
    of the International Water Association. 175 (2020).'
  ieee: 'C. Mi <i>et al.</i>, “The formation of a metalimnetic oxygen minimum exemplifies
    how ecosystem dynamics shape biogeochemical processes: A modelling study,” <i>Water
    research : a journal of the International Water Association</i>, vol. 175, no.
    5, Art. no. 115701, 2020, doi: <a href="https://doi.org/10.1016/j.watres.2020.115701">10.1016/j.watres.2020.115701</a>.'
  mla: 'Mi, Chenxi, et al. “The Formation of a Metalimnetic Oxygen Minimum Exemplifies
    How Ecosystem Dynamics Shape Biogeochemical Processes: A Modelling Study.” <i>Water
    Research : A Journal of the International Water Association</i>, vol. 175, no.
    5, 115701, 2020, <a href="https://doi.org/10.1016/j.watres.2020.115701">https://doi.org/10.1016/j.watres.2020.115701</a>.'
  short: 'C. Mi, T. Shatwell, J. Ma, V.C. Wentzky, B. Boehrer, Y. Xu, K. Rinke, Water
    Research : A Journal of the International Water Association 175 (2020).'
  ufg: '<b>Mi, Chenxi u. a.</b>: The formation of a metalimnetic oxygen minimum exemplifies
    how ecosystem dynamics shape biogeochemical processes: A modelling study, in:
    <i>Water research : a journal of the International Water Association</i> 175 (2020),
    H. 5.'
  van: 'Mi C, Shatwell T, Ma J, Wentzky VC, Boehrer B, Xu Y, et al. The formation
    of a metalimnetic oxygen minimum exemplifies how ecosystem dynamics shape biogeochemical
    processes: A modelling study. Water research : a journal of the International
    Water Association. 2020;175(5).'
date_created: 2024-12-08T20:26:00Z
date_updated: 2024-12-09T10:25:49Z
department:
- _id: DEP8022
doi: 10.1016/j.watres.2020.115701
extern: '1'
intvolume: '       175'
issue: '5'
keyword:
- Rappbode reservoir
- CE-QUAL-W2
- Planktothrix rubescens
- Metalimnion
- Oxygen consumption
- Benthic processes
language:
- iso: eng
main_file_link:
- url: https://doi.org/10.1016/j.watres.2020.115701
place: Amsterdam
publication: 'Water research : a journal of the International Water Association'
publication_identifier:
  eissn:
  - 1879-2448
  issn:
  - 0043-1354
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
status: public
title: 'The formation of a metalimnetic oxygen minimum exemplifies how ecosystem dynamics
  shape biogeochemical processes: A modelling study'
type: scientific_journal_article
user_id: '83781'
volume: 175
year: '2020'
...
---
_id: '12717'
abstract:
- lang: ger
  text: "Der Anstieg der Komplexität in Produktionssystemen stellt eine der größten
    Herausforderungen für produzierende\r\nUnternehmen dar. In der vorliegenden Dissertation
    werden mögliche Auswirkungen von Komplexität auf die Performance von Produktionsgruppen
    untersucht. Es werden sechs Studien durchgeführt, die inhaltlich und methodisch
    aufeinander aufbauen und somit einen vollständigen Forschungsprozess von der initialen
    Begriffsbestimmung bis hin zur Ableitung von Gestaltungsempfehlungen für die betriebliche
    Praxis beschreiben.\r\nIn der Explorationsphase wird zunächst eine qualitative
    Interviewstudie durchgeführt, um konkrete Treiber für das Phänomen der Komplexität
    in digitalisierten Arbeitssystemen zu identifizieren. Basierend auf zwei systematischen
    Literaturstudien wird der Stand der Forschung zu (1) Komplexitätsmodellen und
    (2) Gruppenperformancemodellen im Kontext von Produktionssystemen strukturiert
    erarbeitet und das bestehende Forschungsdefizit offengelegt.\r\nAuf der Grundlage
    der Vorstudien wird ein hypothetisches Modell zur Erklärung der Performance von
    Produktionsgruppen entwickelt, das neben bekannten Einflussgrößen aus der Teamforschung
    verschiedene Komplexitätsdimensionen berücksichtigt. Die Operationalisierung der
    latenten Variablen erfolgt mit Hilfe einer weiteren qualitativen Interviewstudie.
    Das\r\nGruppenperformancemodell wird in einer Fragebogenstudie (n = 455) unter
    Anwendung der Methode der Strukturgleichungsmodellierung empirisch evaluiert.
    In der statistischen Auswertung wird u. a. festgestellt, dass ein positiver Zusammenhang
    zwischen der Aufgabenkomplexität und der Gruppenperformance besteht, der über
    die Qualität der Zusammenarbeit vermittelt wird. Dahingegen wird ein negativer
    Zusammenhang zwischen der Komplexität des Gruppendesigns und der Gruppenperformance
    identifiziert, der ebenfalls über die Qualität der Zusammenarbeit vermittelt wird.
    Aus den Ergebnissen werden konkrete Empfehlungen für die komplexitätsbezogene
    Gestaltung von Gruppenarbeit in der Produktion abgeleitet.\r\nDarüber hinaus wird
    eine Metrik zur Erfassung der Komplexität des Arbeitsprozesses von Produktionsgruppen
    entwickelt und in einer Simulationsstudie evaluiert. Die Metrik kann bereits in
    Planungsphasen von Produktionssystemen verwendet werden, um alternative arbeitsorganisatorische
    Gestaltungsoptionen anhand des resultierenden Komplexitätsniveaus für die Produktionsgruppe
    vergleichend zu analysieren. Zudem können die Auswirkungen unterschiedlicher Qualifikationsprofile
    auf das Komplexitätsniveau und die Performance einer Produktionsgruppe untersucht
    werden."
- lang: eng
  text: "The increase in complexity in production systems represents one of the major
    challenges for manufacturing companies. In this dissertation, possible effects
    of complexity on the performance of production groups are examined. Six studies
    are carried out, which build on each other in terms of content and methodology
    and thus cover a complete research process from\r\nthe initial definition of key
    concepts up to the derivation of design recommendations for operational practice.\r\nWithin
    the exploratory phase, a qualitative interview study is conducted in order to
    identify drivers of the phenomenon of complexity in digitalized work systems.
    Based on two systematic literature studies, the state of research on (1) complexity
    models and (2) group performance models in the context of production systems is
    examined in a structured way and the existing research deficit is pointed out.\r\nOn
    the basis of the preliminary studies, a hypothetical model is developed to explain
    the performance of production groups. The model includes different complexity
    dimensions in addition to known influencing variables from team research. The
    operationalization of the latent variables is carried out with a further qualitative
    interview study. The group performance model is\r\nempirically evaluated in a
    questionnaire study (n = 455) using the method of structural equation modelling.
    On the one hand, the results of the statistical analysis show that there is a
    positive relationship between task complexity and group performance, which is
    mediated by the quality of teamwork. On the other hand, a negative relationship
    is identified between the complexity of group design and group performance, which
    is also mediated by the quality of teamwork. The findings are used to derive specific
    recommendations for the complexity-related design of group work in production.\r\nIn
    addition, a metric to capture the complexity of the work process of production
    groups is developed and evaluated in a simulation study. The metric is applicable
    in early planning phases of production systems. The resulting complexity level
    for the production group can be used for a comparative analysis of organizational
    design options. Furthermore, the effects of\r\ndifferent group qualification profiles
    on the complexity level or performance of a production group can be assessed."
alternative_title:
- 'Effects of complexity on the performance of production groups '
author:
- first_name: Benedikt
  full_name: Latos, Benedikt
  id: '84474'
  last_name: Latos
citation:
  ama: Latos B. <i>Auswirkungen von Komplexität auf die Performance von Produktionsgruppen</i>.
    Vol 37. Shaker Verlag; 2020. doi:<a href="https://doi.org/10.2370/9783844077445">10.2370/9783844077445</a>
  apa: Latos, B. (2020). <i>Auswirkungen von Komplexität auf die Performance von Produktionsgruppen</i>
    (Vol. 37). Shaker Verlag. <a href="https://doi.org/10.2370/9783844077445">https://doi.org/10.2370/9783844077445</a>
  bjps: '<b>Latos B</b> (2020) <i>Auswirkungen von Komplexität auf die Performance
    von Produktionsgruppen</i>. Düren: Shaker Verlag.'
  chicago: 'Latos, Benedikt. <i>Auswirkungen von Komplexität auf die Performance von
    Produktionsgruppen</i>. Vol. 37. Industrial engineering and ergonomics. Düren:
    Shaker Verlag, 2020. <a href="https://doi.org/10.2370/9783844077445">https://doi.org/10.2370/9783844077445</a>.'
  chicago-de: 'Latos, Benedikt. 2020. <i>Auswirkungen von Komplexität auf die Performance
    von Produktionsgruppen</i>. Bd. 37. Industrial engineering and ergonomics. Düren:
    Shaker Verlag. doi:<a href="https://doi.org/10.2370/9783844077445">10.2370/9783844077445</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Latos, Benedikt</span>: <i>Auswirkungen
    von Komplexität auf die Performance von Produktionsgruppen</i>, <i>Industrial
    engineering and ergonomics</i>. Bd. 37. Düren : Shaker Verlag, 2020'
  havard: B. Latos, Auswirkungen von Komplexität auf die Performance von Produktionsgruppen,
    Shaker Verlag, Düren, 2020.
  ieee: 'B. Latos, <i>Auswirkungen von Komplexität auf die Performance von Produktionsgruppen</i>,
    vol. 37. Düren: Shaker Verlag, 2020. doi: <a href="https://doi.org/10.2370/9783844077445">10.2370/9783844077445</a>.'
  mla: Latos, Benedikt. <i>Auswirkungen von Komplexität auf die Performance von Produktionsgruppen</i>.
    Shaker Verlag, 2020, <a href="https://doi.org/10.2370/9783844077445">https://doi.org/10.2370/9783844077445</a>.
  short: B. Latos, Auswirkungen von Komplexität auf die Performance von Produktionsgruppen,
    Shaker Verlag, Düren, 2020.
  ufg: '<b>Latos, Benedikt</b>: Auswirkungen von Komplexität auf die Performance von
    Produktionsgruppen, Bd. 37, Düren 2020 (Industrial engineering and ergonomics).'
  van: 'Latos B. Auswirkungen von Komplexität auf die Performance von Produktionsgruppen.
    Düren: Shaker Verlag; 2020. 324 p. (Industrial engineering and ergonomics; vol.
    37).'
date_created: 2025-03-19T15:33:58Z
date_updated: 2025-03-21T08:30:45Z
defense_date: 2020-10-26
department:
- _id: DEP1500
doi: 10.2370/9783844077445
intvolume: '        37'
keyword:
- Produktionssystem
- Komplexes System
- Teamwork
- Leistungsmessung
language:
- iso: ger
main_file_link:
- url: https://www.shaker.de/Online-Gesamtkatalog-Download/2025.03.19-16.26.58-193.16.112.100-rad4B15C.tmp/978-3-8440-7744-5_INH.PDF
page: '324'
place: Düren
publication_identifier:
  isbn:
  - 978-3-8440-7744-5
publication_status: published
publisher: Shaker Verlag
series_title: Industrial engineering and ergonomics
status: public
supervisor:
- first_name: Susanne
  full_name: Mütze-Niewöhner, Susanne
  last_name: Mütze-Niewöhner
- first_name: Verena
  full_name: Nitsch, Verena
  last_name: Nitsch
title: Auswirkungen von Komplexität auf die Performance von Produktionsgruppen
type: dissertation
user_id: '83781'
volume: 37
year: '2020'
...
---
_id: '12787'
abstract:
- lang: eng
  text: Vapor phase hydrogen peroxide (H2O2) can be utilized to inactivate murine
    norovirus (MNV), a surrogate of human norovirus, on surface areas. However, vapor
    phase H2O2 inactivation of virus on fruits and vegetables has not been characterized.
    In this study, MNV was used to determine whether vaporized H2O2 inactivates virus
    on surfaces of various fruits and vegetables (apples, blueberries, cucumbers,
    and strawberries). The effect of vapor phase H2O2 decontamination was investigated
    with two application systems. Plaque assays were performed after virus recovery
    from untreated and treated fresh produce to compare the quantity of infective
    MNV. The Mann-Whitney U test was applied to the test results to evaluate the virus
    titer reductions of treated food samples, with significance set at P <= 0.05.
    The infective MNV populations were significantly reduced on smooth surfaces by
    4.3 log PFU (apples, P < 0.00001) and 4 log PFU or below the detection limit (blueberries,
    P = 0.0074) by treatment with vapor phase H2O2 (60 min, maximum of 214 ppm of
    H2O2). Similar treatments of artificially contaminated cucumbers resulted in a
    virus titer reduction of 1.9 log PFU. Treatment of inoculated strawberries resulted
    in 0.1and 2.8-log reductions of MNV. However, MNV reduction rates on cucumbers
    (P = 0.3809) and strawberries (P = 0,7414) were not significant. Triangle tests
    and color measurements of untreated and treated apples, cucumbers, blueberries,
    and strawberries revealed no differences in color and consistency after H2O2 treatment.
    No increase of the H2O2 concentration in treated fruits and vegetables compared
    with untreated produce was observed. This study reveals for the first time the
    conditions under which vapor phase H2O2 inactivates MNV on selected fresh fruit
    and vegetable surfaces.
author:
- first_name: Barbara
  full_name: Becker, Barbara
  id: '12640'
  last_name: Becker
- first_name: Mareike
  full_name: Dabisch-Ruthe, Mareike
  id: '66516'
  last_name: Dabisch-Ruthe
  orcid: https://orcid.org/0009-0008-7644-0826
- first_name: Jens
  full_name: Pfannebecker, Jens
  id: '45690'
  last_name: Pfannebecker
  orcid: 0009-0005-4133-5442
citation:
  ama: Becker B, Dabisch-Ruthe M, Pfannebecker J. Inactivation of Murine Norovirus
    on Fruit and Vegetable Surfaces by Vapor Phase Hydrogen Peroxide. <i>  Journal
    of food protection </i>. 2020;83(1):45-51. doi:<a href="https://doi.org/10.4315/0362-028X.JFP-19-238">10.4315/0362-028X.JFP-19-238</a>
  apa: Becker, B., Dabisch-Ruthe, M., &#38; Pfannebecker, J. (2020). Inactivation
    of Murine Norovirus on Fruit and Vegetable Surfaces by Vapor Phase Hydrogen Peroxide.
    <i>  Journal of Food Protection </i>, <i>83</i>(1), 45–51. <a href="https://doi.org/10.4315/0362-028X.JFP-19-238">https://doi.org/10.4315/0362-028X.JFP-19-238</a>
  bjps: <b>Becker B, Dabisch-Ruthe M and Pfannebecker J</b> (2020) Inactivation of
    Murine Norovirus on Fruit and Vegetable Surfaces by Vapor Phase Hydrogen Peroxide.
    <i>  Journal of food protection </i> <b>83</b>, 45–51.
  chicago: 'Becker, Barbara, Mareike Dabisch-Ruthe, and Jens Pfannebecker. “Inactivation
    of Murine Norovirus on Fruit and Vegetable Surfaces by Vapor Phase Hydrogen Peroxide.”
    <i>  Journal of Food Protection </i> 83, no. 1 (2020): 45–51. <a href="https://doi.org/10.4315/0362-028X.JFP-19-238">https://doi.org/10.4315/0362-028X.JFP-19-238</a>.'
  chicago-de: 'Becker, Barbara, Mareike Dabisch-Ruthe und Jens Pfannebecker. 2020.
    Inactivation of Murine Norovirus on Fruit and Vegetable Surfaces by Vapor Phase
    Hydrogen Peroxide. <i>  Journal of food protection </i> 83, Nr. 1: 45–51. doi:<a
    href="https://doi.org/10.4315/0362-028X.JFP-19-238">10.4315/0362-028X.JFP-19-238</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Becker, Barbara</span> ; <span
    style="font-variant:small-caps;">Dabisch-Ruthe, Mareike</span> ; <span style="font-variant:small-caps;">Pfannebecker,
    Jens</span>: Inactivation of Murine Norovirus on Fruit and Vegetable Surfaces
    by Vapor Phase Hydrogen Peroxide. In: <i>  Journal of food protection </i> Bd.
    83. Des Moines, Iowa, IAFP (2020), Nr. 1, S. 45–51'
  havard: B. Becker, M. Dabisch-Ruthe, J. Pfannebecker, Inactivation of Murine Norovirus
    on Fruit and Vegetable Surfaces by Vapor Phase Hydrogen Peroxide,   Journal of
    Food Protection . 83 (2020) 45–51.
  ieee: 'B. Becker, M. Dabisch-Ruthe, and J. Pfannebecker, “Inactivation of Murine
    Norovirus on Fruit and Vegetable Surfaces by Vapor Phase Hydrogen Peroxide,” <i> 
    Journal of food protection </i>, vol. 83, no. 1, pp. 45–51, 2020, doi: <a href="https://doi.org/10.4315/0362-028X.JFP-19-238">10.4315/0362-028X.JFP-19-238</a>.'
  mla: Becker, Barbara, et al. “Inactivation of Murine Norovirus on Fruit and Vegetable
    Surfaces by Vapor Phase Hydrogen Peroxide.” <i>  Journal of Food Protection </i>,
    vol. 83, no. 1, 2020, pp. 45–51, <a href="https://doi.org/10.4315/0362-028X.JFP-19-238">https://doi.org/10.4315/0362-028X.JFP-19-238</a>.
  short: B. Becker, M. Dabisch-Ruthe, J. Pfannebecker,   Journal of Food Protection  83
    (2020) 45–51.
  ufg: '<b>Becker, Barbara/Dabisch-Ruthe, Mareike/Pfannebecker, Jens</b>: Inactivation
    of Murine Norovirus on Fruit and Vegetable Surfaces by Vapor Phase Hydrogen Peroxide,
    in: <i>  Journal of food protection </i> 83 (2020), H. 1,  S. 45–51.'
  van: Becker B, Dabisch-Ruthe M, Pfannebecker J. Inactivation of Murine Norovirus
    on Fruit and Vegetable Surfaces by Vapor Phase Hydrogen Peroxide.   Journal of
    food protection . 2020;83(1):45–51.
date_created: 2025-04-15T07:59:20Z
date_updated: 2025-06-26T13:42:15Z
department:
- _id: DEP4000
doi: 10.4315/0362-028X.JFP-19-238
external_id:
  isi:
  - '000539418200006'
  pmid:
  - '31821018'
intvolume: '        83'
isi: '1'
issue: '1'
keyword:
- Fruits
- Inactivation
- Murine norovirus
- Vapor phase hydrogen peroxide
- Vegetables
language:
- iso: eng
page: 45-51
place: Des Moines, Iowa
pmid: '1'
publication: '  Journal of food protection '
publication_identifier:
  eissn:
  - 1944-9097
  issn:
  - 0362-028X
publication_status: published
publisher: IAFP
quality_controlled: '1'
status: public
title: Inactivation of Murine Norovirus on Fruit and Vegetable Surfaces by Vapor Phase
  Hydrogen Peroxide
type: scientific_journal_article
user_id: '83781'
volume: 83
year: '2020'
...
---
_id: '12794'
abstract:
- lang: eng
  text: "Modern product development utilizes both Product Lifecycle Management (PLM)
    and Application Lifecycle Management (ALM). PLM addresses the hardware lifecycle
    of a product, whereas ALM addresses the software lifecycle. In recent years, industry
    and academia have developed several PLM/ALM integration concepts to realize efficient
    management of the product lifecycle across all domains. However, the solutions
    available in practice are typically vendor-driven. Therefore, they are not generally
    applicable even if standards such as OSLC (Open Services for Lifecycle Cooperation)
    are applied.\r\n\r\nThe consortium \"Plattform Industrie 4.0\" has recently introduced
    a standardized digital representation of an asset (e.g., a smart product): the
    Asset Administration Shell (AAS). The AAS has the potential to integrate PLM/ALM
    data sets in a single product model and hence to provide a generally applicable
    interface for PLM/ALM integration. However, until now there has not been a concept
    to prove this potential. The aim of this work is to develop such new strategies
    (named Plm4AAS) using AAS submodels. This article explains the semi-automatic
    generation of PLM/ALM submodels and how to link elements between these submodels.
    The AASX Package Explorer, an AAS management software tool, is used to demonstrate
    the results. The article finishes with a discussion about the potential of the
    AAS as a standardized concept for PLM/ALM integration. (C) 2020 The Authors. Published
    by Elsevier B.V. Peer-review under responsibility of the scientific committee
    of the 5th International Conference on System-Integrated Intelligence."
author:
- first_name: Andreas
  full_name: Deuter, Andreas
  id: '62088'
  last_name: Deuter
  orcid: 0000-0002-6529-6215
- first_name: Sebastian
  full_name: Imort, Sebastian
  id: '74291'
  last_name: Imort
citation:
  ama: Deuter A, Imort S. <i>PLM/ALM Integration With The Asset Administration Shell</i>.
    Vol 52. (Thoben KD, Dekena B,  Lang W,  Trächtler A, eds.). Elsevier BV; 2020:234-240.
    doi:<a href="https://doi.org/10.1016/j.promfg.2020.11.040">10.1016/j.promfg.2020.11.040</a>
  apa: 'Deuter, A., &#38; Imort, S. (2020). PLM/ALM Integration With The Asset Administration
    Shell. In K.-D. Thoben, B. Dekena, W.  Lang, &#38; A.  Trächtler (Eds.), <i>System-Integrated
    Intelligence - Intelligent, Flexible and Connected Systems in Products and Production :
    Proceedings of the 5th International Conference on System-Integrated Intelligence
    (SysInt 2020), Bremen, Germany (</i> (Vol. 52, pp. 234–240). Elsevier BV. <a href="https://doi.org/10.1016/j.promfg.2020.11.040">https://doi.org/10.1016/j.promfg.2020.11.040</a>'
  bjps: <b>Deuter A and Imort S</b> (2020) <i>PLM/ALM Integration With The Asset Administration
    Shell</i>, Thoben K-D et al. (eds). Elsevier BV.
  chicago: 'Deuter, Andreas, and Sebastian Imort. <i>PLM/ALM Integration With The
    Asset Administration Shell</i>. Edited by Klaus-Dieter  Thoben, Berend  Dekena,
    Walter   Lang, and Ansgar  Trächtler. <i>System-Integrated Intelligence - Intelligent,
    Flexible and Connected Systems in Products and Production : Proceedings of the
    5th International Conference on System-Integrated Intelligence (SysInt 2020),
    Bremen, Germany (</i>. Vol. 52. Procedia Manufacturing. Elsevier BV, 2020. <a
    href="https://doi.org/10.1016/j.promfg.2020.11.040">https://doi.org/10.1016/j.promfg.2020.11.040</a>.'
  chicago-de: 'Deuter, Andreas und Sebastian Imort. 2020. <i>PLM/ALM Integration With
    The Asset Administration Shell</i>. Hg. von Klaus-Dieter  Thoben, Berend  Dekena,
    Walter   Lang, und Ansgar  Trächtler. <i>System-Integrated Intelligence - Intelligent,
    Flexible and Connected Systems in Products and Production : Proceedings of the
    5th International Conference on System-Integrated Intelligence (SysInt 2020),
    Bremen, Germany (</i>. Bd. 52. Procedia Manufacturing. Elsevier BV. doi:<a href="https://doi.org/10.1016/j.promfg.2020.11.040">10.1016/j.promfg.2020.11.040</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Deuter, Andreas</span> ; <span
    style="font-variant:small-caps;">Imort, Sebastian</span> ; <span style="font-variant:small-caps;">Thoben,
    K.-D.</span> ; <span style="font-variant:small-caps;">Dekena, B.</span> ; <span
    style="font-variant:small-caps;"> Lang, W.</span> ; <span style="font-variant:small-caps;">
    Trächtler, A.</span> (Hrsg.): <i>PLM/ALM Integration With The Asset Administration
    Shell</i>, <i>Procedia Manufacturing</i>. Bd. 52 : Elsevier BV, 2020'
  havard: A. Deuter, S. Imort, PLM/ALM Integration With The Asset Administration Shell,
    Elsevier BV, 2020.
  ieee: 'A. Deuter and S. Imort, <i>PLM/ALM Integration With The Asset Administration
    Shell</i>, vol. 52. Elsevier BV, 2020, pp. 234–240. doi: <a href="https://doi.org/10.1016/j.promfg.2020.11.040">10.1016/j.promfg.2020.11.040</a>.'
  mla: 'Deuter, Andreas, and Sebastian Imort. “PLM/ALM Integration With The Asset
    Administration Shell.” <i>System-Integrated Intelligence - Intelligent, Flexible
    and Connected Systems in Products and Production : Proceedings of the 5th International
    Conference on System-Integrated Intelligence (SysInt 2020), Bremen, Germany (</i>,
    edited by Klaus-Dieter  Thoben et al., vol. 52, Elsevier BV, 2020, pp. 234–40,
    <a href="https://doi.org/10.1016/j.promfg.2020.11.040">https://doi.org/10.1016/j.promfg.2020.11.040</a>.'
  short: A. Deuter, S. Imort, PLM/ALM Integration With The Asset Administration Shell,
    Elsevier BV, 2020.
  ufg: '<b>Deuter, Andreas/Imort, Sebastian</b>: PLM/ALM Integration With The Asset
    Administration Shell, Bd. 52, hg. von Thoben, Klaus-Dieter u. a., o. O. 2020 (Procedia
    Manufacturing).'
  van: 'Deuter A, Imort S. PLM/ALM Integration With The Asset Administration Shell.
    Thoben KD, Dekena B,  Lang W,  Trächtler A, editors. System-Integrated Intelligence
    - Intelligent, Flexible and Connected Systems in Products and Production : Proceedings
    of the 5th International Conference on System-Integrated Intelligence (SysInt
    2020), Bremen, Germany (. Elsevier BV; 2020. (Procedia Manufacturing; vol. 52).'
conference:
  end_date: 2020-11-13
  location: Online
  name: 5th International Conference on System-Integrated Intelligence (SysInt)
  start_date: 2020-11-11
date_created: 2025-04-15T10:20:05Z
date_updated: 2025-06-26T13:40:25Z
department:
- _id: DEP7022
- _id: DEP1306
doi: 10.1016/j.promfg.2020.11.040
editor:
- first_name: 'Klaus-Dieter '
  full_name: 'Thoben, Klaus-Dieter '
  last_name: Thoben
- first_name: 'Berend '
  full_name: 'Dekena, Berend '
  last_name: Dekena
- first_name: 'Walter '
  full_name: ' Lang, Walter '
  last_name: ' Lang'
- first_name: Ansgar
  full_name: ' Trächtler, Ansgar'
  last_name: ' Trächtler'
intvolume: '        52'
keyword:
- PLM
- ALM
- ReqIF
- PLM XML
- OSLC
- Asset Administration Shell
language:
- iso: eng
page: 234-240
publication: 'System-Integrated Intelligence - Intelligent, Flexible and Connected
  Systems in Products and Production : Proceedings of the 5th International Conference
  on System-Integrated Intelligence (SysInt 2020), Bremen, Germany ('
publication_identifier:
  issn:
  - 2351-9789
publication_status: published
publisher: Elsevier BV
series_title: Procedia Manufacturing
status: public
title: PLM/ALM Integration With The Asset Administration Shell
type: conference_editor_article
user_id: '83781'
volume: 52
year: '2020'
...
---
_id: '12807'
abstract:
- lang: eng
  text: Writing chorales in the style of Bach has been a music theory exercise for
    generations of music students. As such it is not surprising that automatic Bach
    chorale harmonization has been a topic in music technology for decades. We suggest
    several improvements to current neural network solutions based on musicological
    insights into human choral composition practices. Evaluations with expert listeners
    show that the generated chorales closely resemble Bach's harmonization style.
author:
- first_name: Alexander
  full_name: Leemhuis, Alexander
  last_name: Leemhuis
- first_name: Simon
  full_name: Waloschek, Simon
  last_name: Waloschek
- first_name: Aristotelis
  full_name: Hadjakos, Aristotelis
  id: '58704'
  last_name: Hadjakos
citation:
  ama: Leemhuis A, Waloschek S, Hadjakos A. <i>Bacher than Bach? On Musicologically
    Informed AI-Based Bach Chorale Harmonization</i>. Vol 1168. (Cellier P, Driessens
    K, eds.). Springer International Publishing; 2020:462-469. doi:<a href="https://doi.org/10.1007/978-3-030-43887-6_39">10.1007/978-3-030-43887-6_39</a>
  apa: 'Leemhuis, A., Waloschek, S., &#38; Hadjakos, A. (2020). Bacher than Bach?
    On Musicologically Informed AI-Based Bach Chorale Harmonization. In P. Cellier
    &#38; K. Driessens (Eds.), <i>Machine Learning and Knowledge Discovery in Databases :
    International Workshops of ECML PKDD 2019</i> (Vol. 1168, pp. 462–469). Springer
    International Publishing. <a href="https://doi.org/10.1007/978-3-030-43887-6_39">https://doi.org/10.1007/978-3-030-43887-6_39</a>'
  bjps: '<b>Leemhuis A, Waloschek S and Hadjakos A</b> (2020) <i>Bacher than Bach?
    On Musicologically Informed AI-Based Bach Chorale Harmonization</i>, Cellier P
    and Driessens K (eds). Cham: Springer International Publishing.'
  chicago: 'Leemhuis, Alexander, Simon Waloschek, and Aristotelis Hadjakos. <i>Bacher
    than Bach? On Musicologically Informed AI-Based Bach Chorale Harmonization</i>.
    Edited by Peggy Cellier and Kurt Driessens. <i>Machine Learning and Knowledge
    Discovery in Databases : International Workshops of ECML PKDD 2019</i>. Vol. 1168.
    Communications in Computer and Information Science . Cham: Springer International
    Publishing, 2020. <a href="https://doi.org/10.1007/978-3-030-43887-6_39">https://doi.org/10.1007/978-3-030-43887-6_39</a>.'
  chicago-de: 'Leemhuis, Alexander, Simon Waloschek und Aristotelis Hadjakos. 2020.
    <i>Bacher than Bach? On Musicologically Informed AI-Based Bach Chorale Harmonization</i>.
    Hg. von Peggy Cellier und Kurt Driessens. <i>Machine Learning and Knowledge Discovery
    in Databases : International Workshops of ECML PKDD 2019</i>. Bd. 1168. Communications
    in Computer and Information Science . Cham: Springer International Publishing.
    doi:<a href="https://doi.org/10.1007/978-3-030-43887-6_39">10.1007/978-3-030-43887-6_39</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Leemhuis, Alexander</span>
    ; <span style="font-variant:small-caps;">Waloschek, Simon</span> ; <span style="font-variant:small-caps;">Hadjakos,
    Aristotelis</span> ; <span style="font-variant:small-caps;">Cellier, P.</span>
    ; <span style="font-variant:small-caps;">Driessens, K.</span> (Hrsg.): <i>Bacher
    than Bach? On Musicologically Informed AI-Based Bach Chorale Harmonization</i>,
    <i>Communications in Computer and Information Science </i>. Bd. 1168. Cham : Springer
    International Publishing, 2020'
  havard: A. Leemhuis, S. Waloschek, A. Hadjakos, Bacher than Bach? On Musicologically
    Informed AI-Based Bach Chorale Harmonization, Springer International Publishing,
    Cham, 2020.
  ieee: 'A. Leemhuis, S. Waloschek, and A. Hadjakos, <i>Bacher than Bach? On Musicologically
    Informed AI-Based Bach Chorale Harmonization</i>, vol. 1168. Cham: Springer International
    Publishing, 2020, pp. 462–469. doi: <a href="https://doi.org/10.1007/978-3-030-43887-6_39">10.1007/978-3-030-43887-6_39</a>.'
  mla: 'Leemhuis, Alexander, et al. “Bacher than Bach? On Musicologically Informed
    AI-Based Bach Chorale Harmonization.” <i>Machine Learning and Knowledge Discovery
    in Databases : International Workshops of ECML PKDD 2019</i>, edited by Peggy
    Cellier and Kurt Driessens, vol. 1168, Springer International Publishing, 2020,
    pp. 462–69, <a href="https://doi.org/10.1007/978-3-030-43887-6_39">https://doi.org/10.1007/978-3-030-43887-6_39</a>.'
  short: A. Leemhuis, S. Waloschek, A. Hadjakos, Bacher than Bach? On Musicologically
    Informed AI-Based Bach Chorale Harmonization, Springer International Publishing,
    Cham, 2020.
  ufg: '<b>Leemhuis, Alexander/Waloschek, Simon/Hadjakos, Aristotelis</b>: Bacher
    than Bach? On Musicologically Informed AI-Based Bach Chorale Harmonization, Bd.
    1168, hg. von Cellier, Peggy/Driessens, Kurt, Cham 2020 (Communications in Computer
    and Information Science ).'
  van: 'Leemhuis A, Waloschek S, Hadjakos A. Bacher than Bach? On Musicologically
    Informed AI-Based Bach Chorale Harmonization. Cellier P, Driessens K, editors.
    Machine Learning and Knowledge Discovery in Databases : International Workshops
    of ECML PKDD 2019. Cham: Springer International Publishing; 2020. (Communications
    in Computer and Information Science ; vol. 1168).'
conference:
  end_date: 2019-09-20
  location: Würzburg
  name: European Conference on Machine Learning and Principles and Practice of Knowledge
    Discovery in Databases (ECML PKDD)
  start_date: 2019-09-16
date_created: 2025-04-16T07:52:39Z
date_updated: 2025-06-26T13:36:14Z
department:
- _id: DEP2000
doi: 10.1007/978-3-030-43887-6_39
editor:
- first_name: Peggy
  full_name: Cellier, Peggy
  last_name: Cellier
- first_name: Kurt
  full_name: Driessens, Kurt
  last_name: Driessens
intvolume: '      1168'
keyword:
- Bach chorale harmonization
- Deep learning
- Beam search
language:
- iso: eng
page: 462–469
place: Cham
publication: 'Machine Learning and Knowledge Discovery in Databases : International
  Workshops of ECML PKDD 2019'
publication_identifier:
  eisbn:
  - 978-3-030-43887-6
  eissn:
  - 1865-0937
  isbn:
  - 978-3-030-43886-9
  issn:
  - 1865-0929
publication_status: published
publisher: Springer International Publishing
series_title: 'Communications in Computer and Information Science '
status: public
title: Bacher than Bach? On Musicologically Informed AI-Based Bach Chorale Harmonization
type: conference_editor_article
user_id: '83781'
volume: 1168
year: '2020'
...
---
_id: '12812'
abstract:
- lang: eng
  text: Discerning unexpected from expected data patterns is the key challenge of
    anomaly detection. Although a multitude of solutions has been applied to this
    modern Industry 4.0 problem, it remains an open research issue to identify the
    key characteristics subjacent to an anomaly, sc. generate hypothesis as to why
    they appear. In recent years, machine learning models have been regarded as universal
    solution for a wide range of problems. While most of them suffer from non-self-explanatory
    representations, Gaussian Processes (GPs) deliver interpretable and robust statistical
    data models, which are able to cope with unreliable, noisy, or partially missing
    data. Thus, we regard them as a suitable solution for detecting and appropriately
    representing anomalies and their respective characteristics. In this position
    paper, we discuss the problem of automatic and interpretable anomaly detection
    by means of GPs. That is, we elaborate on why GPs are well suited for anomaly
    detection and what the current challenges are when applying these probabilistic
    models to large-scale production data.
author:
- first_name: Fabian
  full_name: Berns, Fabian
  last_name: Berns
- first_name: Markus
  full_name: Lange-Hegermann, Markus
  id: '71761'
  last_name: Lange-Hegermann
- first_name: Christian
  full_name: Beecks, Christian
  last_name: Beecks
citation:
  ama: Berns F, Lange-Hegermann M, Beecks C. <i>Towards Gaussian Processes for Automatic
    and Interpretable Anomaly Detection in Industry 4.0</i>. (Panetto H, Madani K,
    Smirnov A, eds.). SCITEPRESS - Science and Technology Publications; 2020:87-92.
    doi:<a href="https://doi.org/10.5220/0010130300870092">10.5220/0010130300870092</a>
  apa: Berns, F., Lange-Hegermann, M., &#38; Beecks, C. (2020). Towards Gaussian Processes
    for Automatic and Interpretable Anomaly Detection in Industry 4.0. In H. Panetto,
    K. Madani, &#38; A. Smirnov (Eds.), <i> Proceedings of the International Conference
    on Innovative Intelligent Industrial Production and Logistics IN4PL - Volume 1</i>
    (pp. 87–92). SCITEPRESS - Science and Technology Publications. <a href="https://doi.org/10.5220/0010130300870092">https://doi.org/10.5220/0010130300870092</a>
  bjps: <b>Berns F, Lange-Hegermann M and Beecks C</b> (2020) <i>Towards Gaussian
    Processes for Automatic and Interpretable Anomaly Detection in Industry 4.0</i>,
    Panetto H, Madani K and Smirnov A (eds). SCITEPRESS - Science and Technology Publications.
  chicago: Berns, Fabian, Markus Lange-Hegermann, and Christian Beecks. <i>Towards
    Gaussian Processes for Automatic and Interpretable Anomaly Detection in Industry
    4.0</i>. Edited by H. Panetto, K. Madani, and A. Smirnov. <i> Proceedings of the
    International Conference on Innovative Intelligent Industrial Production and Logistics
    IN4PL - Volume 1</i>. SCITEPRESS - Science and Technology Publications, 2020.
    <a href="https://doi.org/10.5220/0010130300870092">https://doi.org/10.5220/0010130300870092</a>.
  chicago-de: Berns, Fabian, Markus Lange-Hegermann und Christian Beecks. 2020. <i>Towards
    Gaussian Processes for Automatic and Interpretable Anomaly Detection in Industry
    4.0</i>. Hg. von H. Panetto, K. Madani, und A. Smirnov. <i> Proceedings of the
    International Conference on Innovative Intelligent Industrial Production and Logistics
    IN4PL - Volume 1</i>. SCITEPRESS - Science and Technology Publications. doi:<a
    href="https://doi.org/10.5220/0010130300870092">10.5220/0010130300870092</a>,
    .
  din1505-2-1: '<span style="font-variant:small-caps;">Berns, Fabian</span> ; <span
    style="font-variant:small-caps;">Lange-Hegermann, Markus</span> ; <span style="font-variant:small-caps;">Beecks,
    Christian</span> ; <span style="font-variant:small-caps;">Panetto, H.</span> ;
    <span style="font-variant:small-caps;">Madani, K.</span> ; <span style="font-variant:small-caps;">Smirnov,
    A.</span> (Hrsg.): <i>Towards Gaussian Processes for Automatic and Interpretable
    Anomaly Detection in Industry 4.0</i> : SCITEPRESS - Science and Technology Publications,
    2020'
  havard: F. Berns, M. Lange-Hegermann, C. Beecks, Towards Gaussian Processes for
    Automatic and Interpretable Anomaly Detection in Industry 4.0, SCITEPRESS - Science
    and Technology Publications, 2020.
  ieee: 'F. Berns, M. Lange-Hegermann, and C. Beecks, <i>Towards Gaussian Processes
    for Automatic and Interpretable Anomaly Detection in Industry 4.0</i>. SCITEPRESS
    - Science and Technology Publications, 2020, pp. 87–92. doi: <a href="https://doi.org/10.5220/0010130300870092">10.5220/0010130300870092</a>.'
  mla: Berns, Fabian, et al. “Towards Gaussian Processes for Automatic and Interpretable
    Anomaly Detection in Industry 4.0.” <i> Proceedings of the International Conference
    on Innovative Intelligent Industrial Production and Logistics IN4PL - Volume 1</i>,
    edited by H. Panetto et al., SCITEPRESS - Science and Technology Publications,
    2020, pp. 87–92, <a href="https://doi.org/10.5220/0010130300870092">https://doi.org/10.5220/0010130300870092</a>.
  short: F. Berns, M. Lange-Hegermann, C. Beecks, Towards Gaussian Processes for Automatic
    and Interpretable Anomaly Detection in Industry 4.0, SCITEPRESS - Science and
    Technology Publications, 2020.
  ufg: '<b>Berns, Fabian/Lange-Hegermann, Markus/Beecks, Christian</b>: Towards Gaussian
    Processes for Automatic and Interpretable Anomaly Detection in Industry 4.0, hg.
    von Panetto, H./Madani, K./Smirnov, A., o. O. 2020.'
  van: Berns F, Lange-Hegermann M, Beecks C. Towards Gaussian Processes for Automatic
    and Interpretable Anomaly Detection in Industry 4.0. Panetto H, Madani K, Smirnov
    A, editors.  Proceedings of the International Conference on Innovative Intelligent
    Industrial Production and Logistics IN4PL - Volume 1. SCITEPRESS - Science and
    Technology Publications; 2020.
conference:
  end_date: 2020-11-04
  location: Budapest, HUNGARY
  name: International Conference on Innovative Intelligent Industrial Production and
    Logistics (IN4PL)
  start_date: 2020-11-02
date_created: 2025-04-17T06:20:07Z
date_updated: 2025-06-26T13:31:38Z
department:
- _id: DEP5000
doi: 10.5220/0010130300870092
editor:
- first_name: H.
  full_name: Panetto, H.
  last_name: Panetto
- first_name: K.
  full_name: Madani, K.
  last_name: Madani
- first_name: A.
  full_name: Smirnov, A.
  last_name: Smirnov
keyword:
- Anomaly Detection
- Gaussian Processes
- Explainable Machine Learning
- Industry 4.0
language:
- iso: eng
page: 87-92
publication: ' Proceedings of the International Conference on Innovative Intelligent
  Industrial Production and Logistics IN4PL - Volume 1'
publication_identifier:
  isbn:
  - 978-989-758-476-3
publication_status: published
publisher: SCITEPRESS - Science and Technology Publications
status: public
title: Towards Gaussian Processes for Automatic and Interpretable Anomaly Detection
  in Industry 4.0
type: conference_editor_article
user_id: '83781'
year: '2020'
...
---
_id: '12835'
abstract:
- lang: eng
  text: Delayed-release dosage forms are mainly manufactured as batch processes and
    include coated tablets, pellets, or particles with gastric resistant polymers.
    Authors propose a novel approach using the hot-melt extrusion technique to prepare
    delayed release dosage forms via a continuous manufacturing process, a new trend
    in the pharmaceutical industry. A full factorial design was employed to correlate
    input variables, including stearic acid (SA) content, drug content, and pellet
    size with drug release properties of the pellets. PLS fit method suitably elaborated
    the relationship between input and output variables with reasonably good fit and
    goodness of prediction. All three input factors influenced drug release in enzyme-free
    simulated gastric fluid (SGF) after 120 min; however, SA content did not significantly
    affect drug dissolution in the enzyme-free simulated intestinal fluid (SIF). An
    optimized formulation and design space were determined by overlaying multiple
    contours established from regression equations. The continuous manufacturing process
    was successfully monitored using inline near-infrared (NIR) and inline particle
    size analysis, with drug load and pellet size being well-controlled within the
    design space. The obtained pellets released less than 5% after 120 min in SGF
    and more than 85% and 95% after 30 min and 45 min, respectively, after switching
    to SIF. (C) 2020 American Pharmacists Association (R). Published by Elsevier Inc.
    All rights reserved.
author:
- first_name: Anh Q.
  full_name: Vo, Anh Q.
  last_name: Vo
- first_name: Gerd
  full_name: Kutz, Gerd
  id: '12015'
  last_name: Kutz
- first_name: Herman
  full_name: He, Herman
  last_name: He
- first_name: Sagar
  full_name: Narala, Sagar
  last_name: Narala
- first_name: Suresh
  full_name: Bandari, Suresh
  last_name: Bandari
- first_name: Michael A.
  full_name: Repka, Michael A.
  last_name: Repka
citation:
  ama: 'Vo AQ, Kutz G, He H, Narala S, Bandari S, Repka MA. Continuous Manufacturing
    of Ketoprofen Delayed Release Pellets Using Melt Extrusion Technology: Application
    of QbD Design Space, Inline Near Infrared, and Inline Pellet Size Analysis. <i>Journal
    of Pharmaceutical Sciences</i>. 2020;109(12):3598-3607. doi:<a href="https://doi.org/10.1016/j.xphs.2020.09.007">10.1016/j.xphs.2020.09.007</a>'
  apa: 'Vo, A. Q., Kutz, G., He, H., Narala, S., Bandari, S., &#38; Repka, M. A. (2020).
    Continuous Manufacturing of Ketoprofen Delayed Release Pellets Using Melt Extrusion
    Technology: Application of QbD Design Space, Inline Near Infrared, and Inline
    Pellet Size Analysis. <i>Journal of Pharmaceutical Sciences</i>, <i>109</i>(12),
    3598–3607. <a href="https://doi.org/10.1016/j.xphs.2020.09.007">https://doi.org/10.1016/j.xphs.2020.09.007</a>'
  bjps: '<b>Vo AQ <i>et al.</i></b> (2020) Continuous Manufacturing of Ketoprofen
    Delayed Release Pellets Using Melt Extrusion Technology: Application of QbD Design
    Space, Inline Near Infrared, and Inline Pellet Size Analysis. <i>Journal of Pharmaceutical
    Sciences</i> <b>109</b>, 3598–3607.'
  chicago: 'Vo, Anh Q., Gerd Kutz, Herman He, Sagar Narala, Suresh Bandari, and Michael
    A. Repka. “Continuous Manufacturing of Ketoprofen Delayed Release Pellets Using
    Melt Extrusion Technology: Application of QbD Design Space, Inline Near Infrared,
    and Inline Pellet Size Analysis.” <i>Journal of Pharmaceutical Sciences</i> 109,
    no. 12 (2020): 3598–3607. <a href="https://doi.org/10.1016/j.xphs.2020.09.007">https://doi.org/10.1016/j.xphs.2020.09.007</a>.'
  chicago-de: 'Vo, Anh Q., Gerd Kutz, Herman He, Sagar Narala, Suresh Bandari und
    Michael A. Repka. 2020. Continuous Manufacturing of Ketoprofen Delayed Release
    Pellets Using Melt Extrusion Technology: Application of QbD Design Space, Inline
    Near Infrared, and Inline Pellet Size Analysis. <i>Journal of Pharmaceutical Sciences</i>
    109, Nr. 12: 3598–3607. doi:<a href="https://doi.org/10.1016/j.xphs.2020.09.007">10.1016/j.xphs.2020.09.007</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Vo, Anh Q.</span> ; <span style="font-variant:small-caps;">Kutz,
    Gerd</span> ; <span style="font-variant:small-caps;">He, Herman</span> ; <span
    style="font-variant:small-caps;">Narala, Sagar</span> ; <span style="font-variant:small-caps;">Bandari,
    Suresh</span> ; <span style="font-variant:small-caps;">Repka, Michael A.</span>:
    Continuous Manufacturing of Ketoprofen Delayed Release Pellets Using Melt Extrusion
    Technology: Application of QbD Design Space, Inline Near Infrared, and Inline
    Pellet Size Analysis. In: <i>Journal of Pharmaceutical Sciences</i> Bd. 109. Amsterdam
    [u.a.], Elsevier BV (2020), Nr. 12, S. 3598–3607'
  havard: 'A.Q. Vo, G. Kutz, H. He, S. Narala, S. Bandari, M.A. Repka, Continuous
    Manufacturing of Ketoprofen Delayed Release Pellets Using Melt Extrusion Technology:
    Application of QbD Design Space, Inline Near Infrared, and Inline Pellet Size
    Analysis, Journal of Pharmaceutical Sciences. 109 (2020) 3598–3607.'
  ieee: 'A. Q. Vo, G. Kutz, H. He, S. Narala, S. Bandari, and M. A. Repka, “Continuous
    Manufacturing of Ketoprofen Delayed Release Pellets Using Melt Extrusion Technology:
    Application of QbD Design Space, Inline Near Infrared, and Inline Pellet Size
    Analysis,” <i>Journal of Pharmaceutical Sciences</i>, vol. 109, no. 12, pp. 3598–3607,
    2020, doi: <a href="https://doi.org/10.1016/j.xphs.2020.09.007">10.1016/j.xphs.2020.09.007</a>.'
  mla: 'Vo, Anh Q., et al. “Continuous Manufacturing of Ketoprofen Delayed Release
    Pellets Using Melt Extrusion Technology: Application of QbD Design Space, Inline
    Near Infrared, and Inline Pellet Size Analysis.” <i>Journal of Pharmaceutical
    Sciences</i>, vol. 109, no. 12, 2020, pp. 3598–607, <a href="https://doi.org/10.1016/j.xphs.2020.09.007">https://doi.org/10.1016/j.xphs.2020.09.007</a>.'
  short: A.Q. Vo, G. Kutz, H. He, S. Narala, S. Bandari, M.A. Repka, Journal of Pharmaceutical
    Sciences 109 (2020) 3598–3607.
  ufg: '<b>Vo, Anh Q. u. a.</b>: Continuous Manufacturing of Ketoprofen Delayed Release
    Pellets Using Melt Extrusion Technology: Application of QbD Design Space, Inline
    Near Infrared, and Inline Pellet Size Analysis, in: <i>Journal of Pharmaceutical
    Sciences</i> 109 (2020), H. 12,  S. 3598–3607.'
  van: 'Vo AQ, Kutz G, He H, Narala S, Bandari S, Repka MA. Continuous Manufacturing
    of Ketoprofen Delayed Release Pellets Using Melt Extrusion Technology: Application
    of QbD Design Space, Inline Near Infrared, and Inline Pellet Size Analysis. Journal
    of Pharmaceutical Sciences. 2020;109(12):3598–607.'
date_created: 2025-04-23T08:40:12Z
date_updated: 2025-06-26T13:25:32Z
department:
- _id: DEP4028
doi: 10.1016/j.xphs.2020.09.007
external_id:
  isi:
  - '000590406100010'
intvolume: '       109'
isi: '1'
issue: '12'
keyword:
- Continuous manufacturing
- Delayed-release
- FT-NIR
- Inline particle size analysis
- Hot melt extrusion
language:
- iso: eng
page: 3598-3607
place: Amsterdam [u.a.]
publication: Journal of Pharmaceutical Sciences
publication_identifier:
  eissn:
  - 1520-6017
  issn:
  - 0022-3549
publication_status: published
publisher: Elsevier BV
status: public
title: 'Continuous Manufacturing of Ketoprofen Delayed Release Pellets Using Melt
  Extrusion Technology: Application of QbD Design Space, Inline Near Infrared, and
  Inline Pellet Size Analysis'
type: scientific_journal_article
user_id: '83781'
volume: 109
year: '2020'
...
---
_id: '12857'
abstract:
- lang: eng
  text: On the occasion of the 250th anniversary celebrations of Ludwig van Beethoven
    in 2020, we developed the musical room installation "Inside Beethoven! The Audience
    Goes on Stage". It is a stage with virtual musicians. Visitors are invited to
    enter, take the position of the musicians and listen to each of them at close
    range. The installation emulates the listening perspective of the musicians, thus,
    providing an uncommon experience to visitors who are mostly used to listen to
    music from recordings or from a concert audience's perspective. The musicians
    play Beethoven's septet op. 20 and its trio arrangement op. 38, two exclusive
    14 channel music productions. Both versions are aligned and can be switched seamlessly.
    Digital music stands visualize the score. In this paper we trace the genesis and
    construction of the installation and point at some conceptual and technical challenges
    tackled.
alternative_title:
- a musical installation for a new listening perspective
author:
- first_name: Axel
  full_name: Berndt, Axel
  last_name: Berndt
- first_name: Simon
  full_name: Waloschek, Simon
  last_name: Waloschek
- first_name: Aristotelis
  full_name: Hadjakos, Aristotelis
  id: '58704'
  last_name: Hadjakos
- first_name: Joachim
  full_name: Veit, Joachim
  last_name: Veit
citation:
  ama: Berndt A, Waloschek S, Hadjakos A, Veit J. <i>Inside Beethoven!</i> (Groß-Vogt
    K, ed.). ACM; 2020:245-248. doi:<a href="https://doi.org/10.1145/3411109.3411115">10.1145/3411109.3411115</a>
  apa: Berndt, A., Waloschek, S., Hadjakos, A., &#38; Veit, J. (2020). Inside Beethoven!
    In K. Groß-Vogt (Ed.), <i>Proceedings of the 15th International Audio Mostly Conference</i>
    (pp. 245–248). ACM. <a href="https://doi.org/10.1145/3411109.3411115">https://doi.org/10.1145/3411109.3411115</a>
  bjps: '<b>Berndt A <i>et al.</i></b> (2020) <i>Inside Beethoven!</i>, Groß-Vogt
    K (ed.). New York, NY: ACM.'
  chicago: 'Berndt, Axel, Simon Waloschek, Aristotelis Hadjakos, and Joachim Veit.
    <i>Inside Beethoven!</i> Edited by Katharina  Groß-Vogt. <i>Proceedings of the
    15th International Audio Mostly Conference</i>. New York, NY: ACM, 2020. <a href="https://doi.org/10.1145/3411109.3411115">https://doi.org/10.1145/3411109.3411115</a>.'
  chicago-de: 'Berndt, Axel, Simon Waloschek, Aristotelis Hadjakos und Joachim Veit.
    2020. <i>Inside Beethoven!</i> Hg. von Katharina  Groß-Vogt. <i>Proceedings of
    the 15th International Audio Mostly Conference</i>. New York, NY: ACM. doi:<a
    href="https://doi.org/10.1145/3411109.3411115">10.1145/3411109.3411115</a>, .'
  din1505-2-1: '<span style="font-variant:small-caps;">Berndt, Axel</span> ; <span
    style="font-variant:small-caps;">Waloschek, Simon</span> ; <span style="font-variant:small-caps;">Hadjakos,
    Aristotelis</span> ; <span style="font-variant:small-caps;">Veit, Joachim</span>
    ; <span style="font-variant:small-caps;">Groß-Vogt, K.</span> (Hrsg.): <i>Inside
    Beethoven!</i> New York, NY : ACM, 2020'
  havard: A. Berndt, S. Waloschek, A. Hadjakos, J. Veit, Inside Beethoven!, ACM, New
    York, NY, 2020.
  ieee: 'A. Berndt, S. Waloschek, A. Hadjakos, and J. Veit, <i>Inside Beethoven!</i>
    New York, NY: ACM, 2020, pp. 245–248. doi: <a href="https://doi.org/10.1145/3411109.3411115">10.1145/3411109.3411115</a>.'
  mla: Berndt, Axel, et al. “Inside Beethoven!” <i>Proceedings of the 15th International
    Audio Mostly Conference</i>, edited by Katharina  Groß-Vogt, ACM, 2020, pp. 245–48,
    <a href="https://doi.org/10.1145/3411109.3411115">https://doi.org/10.1145/3411109.3411115</a>.
  short: A. Berndt, S. Waloschek, A. Hadjakos, J. Veit, Inside Beethoven!, ACM, New
    York, NY, 2020.
  ufg: '<b>Berndt, Axel u. a.</b>: Inside Beethoven!, hg. von Groß-Vogt, Katharina,
    New York, NY 2020.'
  van: 'Berndt A, Waloschek S, Hadjakos A, Veit J. Inside Beethoven! Groß-Vogt K,
    editor. Proceedings of the 15th International Audio Mostly Conference. New York,
    NY: ACM; 2020.'
conference:
  end_date: 2020-09-17
  location: Graz, AUSTRIA
  name: 15th International Audio Mostly Conference (AM)
  start_date: 2020-09-15
date_created: 2025-04-24T07:46:39Z
date_updated: 2025-06-26T09:01:06Z
department:
- _id: DEP2000
doi: 10.1145/3411109.3411115
editor:
- first_name: 'Katharina '
  full_name: 'Groß-Vogt, Katharina '
  last_name: Groß-Vogt
keyword:
- Beethoven
- Music
- Artistic Installation
language:
- iso: eng
page: 245-248
place: New York, NY
publication: Proceedings of the 15th International Audio Mostly Conference
publication_identifier:
  isbn:
  - 978-1-4503-7563-4
publication_status: published
publisher: ACM
status: public
title: Inside Beethoven!
type: conference_editor_article
user_id: '83781'
year: '2020'
...
---
_id: '12955'
abstract:
- lang: ger
  text: Ein 10 Monate alter, männlich intakter Rhodesian Ridgeback wurde wegen chronischen
    Dickdarmdurchfalls und Hämatochezie vorgestellt. Der Hund stammte aus Deutschland
    und hatte das Land nie verlassen. Die Laboruntersuchung des vorbehandelnden Tierarztes
    ergab neben einer Neutrophilie eine Hyperkaliämie und eine Hyponatriämie. Mit
    einem Serumbasalkortisolwert von 4,3 µg/dl konnte ein Hypoadrenokortizismus weitgehend
    ausgeschlossen werden. Eine vom Tierarzt durch geführte antibiotische Behandlung
    hatte keine Besserung bewirkt. Daher war der Hund mit Prednisolon behandelt worden.
    Unter 2-wöchiger Prednisolongabe kam es zu einer deutlichen Verstärkung des Durchfalls
    sowie einem Gewichtsverlust von 6 kg. Bei Vorstellung an der Medizinischen Kleintierklinik
    der LMU München war der Hund im Allgemeinbefinden mittelgradig reduziert, deutlich
    abgemagert, dehydriert, hypovolämisch und hatte eine rektale Körpertemperatur
    von 39,6 °C. Bei der sonografischen Untersuchung zeigte sich eine generalisiert
    verdickte Dickdarmwand und koloskopisch eine hochgradig ulzerativ veränderte Dickdarmschleimhaut.
    Histologischer Befund war eine ulzerative granulomatöse Kolitis. Durch die Periodic-Acid-Schiff-Reaktion
    ließen sich in den Schnitten der Dickdarmbioptate mikrobielle Strukturen darstellen,
    die für eine Algeninfektion diagnostisch waren. Die bei der mikrobiellen Untersuchung
    anzüchtbaren Prototheken wurden mittels MALDI-TOF-MS als Prototheca zopfii identifiziert.
    Zum Nachweis einer möglichen Immundefizienz wurden die Immunglobuline im Serum
    bestimmt. Die IgM-Konzentration war erniedrigt, während sich IgG- und IgA-Konzentration
    im Referenzbereich befanden. Aufgrund der Verschlechterung des Allgemeinbefindens,
    der vorsichtigen Prognose und der hohen Kosten eines Therapieversuchs wurde der
    Hund eine Woche später euthanasiert und der Tierkörper pathologisch untersucht.
    Histopathologisch wurden Prototheken auch in den abdominalen Lymphknoten, jedoch
    nicht in den Augen oder im zentralen Nervensystem identifiziert. Der Fall zeigt,
    dass eine Prototheken-Infektion auch bei Hunden aus Deutschland als Differenzialdiagnose
    für chronischen Dickdarmdurchfall in Betracht gezogen werden sollte, insbesondere
    bei Patienten mit ulzerativer granulomatöser Kolitis. Sie kann bei der histologischen
    Untersuchung ohne Spezialfärbung leicht übersehen werden.
- lang: eng
  text: A 10-month-old male Rhodesian Ridgeback was presented to the Clinic of Small
    Animal Medicine, LMU, Germany, with a 6-month history of chronic diarrhea and
    hematochezia. The dog lived in Germany and had never traveled abroad. Complete
    blood count and serum biochemistry performed by the referring veterinarian revealed
    neutrophilia, hyperkalemia, and hyponatremia, with a basal cortisol of 4.3 µg/dl,
    which excluded hypoadrenocorticism. Since antibiotic treatment had not resulted
    in any improvement, a 2 week course of prednisolone administration had been initiated,
    leading to a marked deterioration of intestinal signs and a significant weight
    loss of 6 kg. At the time of referral, the patient was markedly emaciated, dehydrated,
    hypovolemic and had a rectal temperature of 39.6 °C. Abdominal ultrasound showed
    a thickened and irregular colonic wall. On colonoscopy, an irregular colonic mucosa
    with ulcerations was observed. Histopathologic examination revealed an ulcerative
    granulomatous colitis, and on Periodic acid-Schiff reaction (PAS) numerous organisms
    consistent with Prototheca spp. were identified. Prototheca zopfii infection was
    confirmed by culture and MALDI-TOF MS. In order to test for an underlying immunodeficiency,
    immunoglobulin levels in serum were determined. IgM was decreased, while IgG and
    IgA levels were within the reference interval. Due to deterioration of general
    condition, grave prognosis and costs of a treatment trial, the patient was euthanized
    one week later, and necropsy was performed. Prototheca spp. were detected on histopathologic
    examination in the lymphnodes, however not in the eyes or the central nervous
    system. Protothecosis should be considered an differential diagnosis in dogs with
    chronic diarrhea and ulcerative granulomatous colitis even in dogs living in Germany.
    Histopathologic examination of colonic biopsies with special stains such as PAS
    is recommended in every dog with signs of chronic large bowel disease in order
    to avoid missing this rare infectious disease.
author:
- first_name: Vera
  full_name: Geisen, Vera
  last_name: Geisen
- first_name: Christian
  full_name: Mayer, Christian
  last_name: Mayer
- first_name: Julia
  full_name: Harrer, Julia
  last_name: Harrer
- first_name: Katrin
  full_name: Hartmann, Katrin
  last_name: Hartmann
- first_name: Sebastian
  full_name: Ulrich, Sebastian
  id: '85847'
  last_name: Ulrich
  orcid: 0000-0002-4511-9537
- first_name: Stefan
  full_name: Unterer, Stefan
  last_name: Unterer
citation:
  ama: 'Geisen V, Mayer C, Harrer J, Hartmann K, Ulrich S, Unterer S. Ulzerative granulomatöse
    Kolitis durch Prototheca spp. bei einem Rhodesian Ridgeback in Deutschland. <i>Tierärztliche
    Praxis Ausgabe K: Kleintiere / Heimtiere</i>. 2020;48(05):369-375. doi:<a href="https://doi.org/10.1055/a-1238-1554">10.1055/a-1238-1554</a>'
  apa: 'Geisen, V., Mayer, C., Harrer, J., Hartmann, K., Ulrich, S., &#38; Unterer,
    S. (2020). Ulzerative granulomatöse Kolitis durch Prototheca spp. bei einem Rhodesian
    Ridgeback in Deutschland. <i>Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere</i>,
    <i>48</i>(05), 369–375. <a href="https://doi.org/10.1055/a-1238-1554">https://doi.org/10.1055/a-1238-1554</a>'
  bjps: '<b>Geisen V <i>et al.</i></b> (2020) Ulzerative granulomatöse Kolitis durch
    Prototheca spp. bei einem Rhodesian Ridgeback in Deutschland. <i>Tierärztliche
    Praxis Ausgabe K: Kleintiere / Heimtiere</i> <b>48</b>, 369–375.'
  chicago: 'Geisen, Vera, Christian Mayer, Julia Harrer, Katrin Hartmann, Sebastian
    Ulrich, and Stefan Unterer. “Ulzerative granulomatöse Kolitis durch Prototheca
    spp. bei einem Rhodesian Ridgeback in Deutschland.” <i>Tierärztliche Praxis Ausgabe
    K: Kleintiere / Heimtiere</i> 48, no. 05 (2020): 369–75. <a href="https://doi.org/10.1055/a-1238-1554">https://doi.org/10.1055/a-1238-1554</a>.'
  chicago-de: 'Geisen, Vera, Christian Mayer, Julia Harrer, Katrin Hartmann, Sebastian
    Ulrich und Stefan Unterer. 2020. Ulzerative granulomatöse Kolitis durch Prototheca
    spp. bei einem Rhodesian Ridgeback in Deutschland. <i>Tierärztliche Praxis Ausgabe
    K: Kleintiere / Heimtiere</i> 48, Nr. 05: 369–375. doi:<a href="https://doi.org/10.1055/a-1238-1554">10.1055/a-1238-1554</a>,
    .'
  din1505-2-1: '<span style="font-variant:small-caps;">Geisen, Vera</span> ; <span
    style="font-variant:small-caps;">Mayer, Christian</span> ; <span style="font-variant:small-caps;">Harrer,
    Julia</span> ; <span style="font-variant:small-caps;">Hartmann, Katrin</span>
    ; <span style="font-variant:small-caps;">Ulrich, Sebastian</span> ; <span style="font-variant:small-caps;">Unterer,
    Stefan</span>: Ulzerative granulomatöse Kolitis durch Prototheca spp. bei einem
    Rhodesian Ridgeback in Deutschland. In: <i>Tierärztliche Praxis Ausgabe K: Kleintiere
    / Heimtiere</i> Bd. 48. Stuttgart, Thieme  (2020), Nr. 05, S. 369–375'
  havard: 'V. Geisen, C. Mayer, J. Harrer, K. Hartmann, S. Ulrich, S. Unterer, Ulzerative
    granulomatöse Kolitis durch Prototheca spp. bei einem Rhodesian Ridgeback in Deutschland,
    Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere. 48 (2020) 369–375.'
  ieee: 'V. Geisen, C. Mayer, J. Harrer, K. Hartmann, S. Ulrich, and S. Unterer, “Ulzerative
    granulomatöse Kolitis durch Prototheca spp. bei einem Rhodesian Ridgeback in Deutschland,”
    <i>Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere</i>, vol. 48, no. 05,
    pp. 369–375, 2020, doi: <a href="https://doi.org/10.1055/a-1238-1554">10.1055/a-1238-1554</a>.'
  mla: 'Geisen, Vera, et al. “Ulzerative granulomatöse Kolitis durch Prototheca spp.
    bei einem Rhodesian Ridgeback in Deutschland.” <i>Tierärztliche Praxis Ausgabe
    K: Kleintiere / Heimtiere</i>, vol. 48, no. 05, 2020, pp. 369–75, <a href="https://doi.org/10.1055/a-1238-1554">https://doi.org/10.1055/a-1238-1554</a>.'
  short: 'V. Geisen, C. Mayer, J. Harrer, K. Hartmann, S. Ulrich, S. Unterer, Tierärztliche
    Praxis Ausgabe K: Kleintiere / Heimtiere 48 (2020) 369–375.'
  ufg: '<b>Geisen, Vera u. a.</b>: Ulzerative granulomatöse Kolitis durch Prototheca
    spp. bei einem Rhodesian Ridgeback in Deutschland, in: <i>Tierärztliche Praxis
    Ausgabe K: Kleintiere / Heimtiere</i> 48 (2020), H. 05,  S. 369–375.'
  van: 'Geisen V, Mayer C, Harrer J, Hartmann K, Ulrich S, Unterer S. Ulzerative granulomatöse
    Kolitis durch Prototheca spp. bei einem Rhodesian Ridgeback in Deutschland. Tierärztliche
    Praxis Ausgabe K: Kleintiere / Heimtiere. 2020;48(05):369–75.'
date_created: 2025-06-15T10:01:12Z
date_updated: 2025-06-18T12:24:09Z
department:
- _id: DEP4010
doi: 10.1055/a-1238-1554
extern: '1'
intvolume: '        48'
issue: '05'
keyword:
- Hund - Algeninfektion - chronischer Durchfall - Protothekose - Prototheca zopfii
language:
- iso: ger
page: 369-375
place: Stuttgart
publication: 'Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere'
publication_identifier:
  eissn:
  - 2567-5842
  issn:
  - 1434-1239
publication_status: published
publisher: 'Thieme '
status: public
title: Ulzerative granulomatöse Kolitis durch Prototheca spp. bei einem Rhodesian
  Ridgeback in Deutschland
type: scientific_journal_article
user_id: '83781'
volume: 48
year: '2020'
...
---
_id: '12956'
abstract:
- lang: eng
  text: Stachybotrys (S.) chartarum had been linked to severe health problems in humans
    and animals, which occur after exposure to the toxic secondary metabolites of
    this mold. S. chartarum had been isolated from different environmental sources,
    ranging from culinary herbs and improperly stored fodder to damp building materials.
    To access the pathogenic potential of isolates, it is essential to analyze them
    under defined conditions that allow for the production of their toxic metabolites.
    All Stachybotrys species are assumed to produce the immunosuppressive phenylspirodrimanes,
    but the highly cytotoxic macrocyclic trichothecenes are exclusively generated
    by the genotype S of S. chartarum. In this study, we have analyzed four genotype
    S strains initially isolated from three different habitats. We grew them on five
    commonly used media (malt-extract-agar, glucose-yeast-peptone-agar, potato-dextrose-agar,
    cellulose-agar, Sabouraud-dextrose-agar) to identify conditions that promote mycotoxin
    production. Using LC-MS/MS, we have quantified stachybotrylactam and all S-type
    specific macrocyclic trichothecenes (satratoxin G, H, F, roridin E, L-2, verrucarin
    J). All five media supported a comparable fungal growth and sporulation at 25
    °C in the dark. The highest concentrations of macrocyclic trichothecenes were
    detected on potato-dextrose-agar or cellulose-agar. Malt-extract-agar let to an
    intermediate and glucose-yeast-peptone-agar and Sabouraud-dextrose-agar to a poor
    mycotoxin production. These data demonstrate that the mycotoxin production clearly
    depends on the composition of the respective medium. Our findings provide a starting
    point for further studies in order to identify individual components that either
    support or repress the production of mycotoxins in S. chartarum.
article_number: '159'
author:
- first_name: Sebastian
  full_name: Ulrich, Sebastian
  id: '85847'
  last_name: Ulrich
  orcid: 0000-0002-4511-9537
- first_name: Cornelius
  full_name: Schäfer, Cornelius
  last_name: Schäfer
citation:
  ama: Ulrich S, Schäfer C. Toxin Production by Stachybotrys chartarum Genotype S
    on Different Culture Media. <i>Journal of Fungi</i>. 2020;6(3). doi:<a href="https://doi.org/10.3390/jof6030159">10.3390/jof6030159</a>
  apa: Ulrich, S., &#38; Schäfer, C. (2020). Toxin Production by Stachybotrys chartarum
    Genotype S on Different Culture Media. <i>Journal of Fungi</i>, <i>6</i>(3), Article
    159. <a href="https://doi.org/10.3390/jof6030159">https://doi.org/10.3390/jof6030159</a>
  bjps: <b>Ulrich S and Schäfer C</b> (2020) Toxin Production by Stachybotrys Chartarum
    Genotype S on Different Culture Media. <i>Journal of Fungi</i> <b>6</b>.
  chicago: Ulrich, Sebastian, and Cornelius Schäfer. “Toxin Production by Stachybotrys
    Chartarum Genotype S on Different Culture Media.” <i>Journal of Fungi</i> 6, no.
    3 (2020). <a href="https://doi.org/10.3390/jof6030159">https://doi.org/10.3390/jof6030159</a>.
  chicago-de: Ulrich, Sebastian und Cornelius Schäfer. 2020. Toxin Production by Stachybotrys
    chartarum Genotype S on Different Culture Media. <i>Journal of Fungi</i> 6, Nr.
    3. doi:<a href="https://doi.org/10.3390/jof6030159">10.3390/jof6030159</a>, .
  din1505-2-1: '<span style="font-variant:small-caps;">Ulrich, Sebastian</span> ;
    <span style="font-variant:small-caps;">Schäfer, Cornelius</span>: Toxin Production
    by Stachybotrys chartarum Genotype S on Different Culture Media. In: <i>Journal
    of Fungi</i> Bd. 6. Basel, MDPI  (2020), Nr. 3'
  havard: S. Ulrich, C. Schäfer, Toxin Production by Stachybotrys chartarum Genotype
    S on Different Culture Media, Journal of Fungi. 6 (2020).
  ieee: 'S. Ulrich and C. Schäfer, “Toxin Production by Stachybotrys chartarum Genotype
    S on Different Culture Media,” <i>Journal of Fungi</i>, vol. 6, no. 3, Art. no.
    159, 2020, doi: <a href="https://doi.org/10.3390/jof6030159">10.3390/jof6030159</a>.'
  mla: Ulrich, Sebastian, and Cornelius Schäfer. “Toxin Production by Stachybotrys
    Chartarum Genotype S on Different Culture Media.” <i>Journal of Fungi</i>, vol.
    6, no. 3, 159, 2020, <a href="https://doi.org/10.3390/jof6030159">https://doi.org/10.3390/jof6030159</a>.
  short: S. Ulrich, C. Schäfer, Journal of Fungi 6 (2020).
  ufg: '<b>Ulrich, Sebastian/Schäfer, Cornelius</b>: Toxin Production by Stachybotrys
    chartarum Genotype S on Different Culture Media, in: <i>Journal of Fungi</i> 6
    (2020), H. 3.'
  van: Ulrich S, Schäfer C. Toxin Production by Stachybotrys chartarum Genotype S
    on Different Culture Media. Journal of Fungi. 2020;6(3).
date_created: 2025-06-15T10:01:42Z
date_updated: 2025-06-16T13:59:56Z
department:
- _id: DEP4010
doi: 10.3390/jof6030159
extern: '1'
intvolume: '         6'
issue: '3'
keyword:
- Stachybotrys
- genotype
- macrocyclic trichothecenes
- stachybotrylactam
language:
- iso: eng
place: Basel
publication: Journal of Fungi
publication_identifier:
  eissn:
  - 2309-608X
publication_status: published
publisher: 'MDPI '
quality_controlled: '1'
status: public
title: Toxin Production by Stachybotrys chartarum Genotype S on Different Culture
  Media
type: scientific_journal_article
user_id: '83781'
volume: 6
year: '2020'
...
---
_id: '12962'
abstract:
- lang: eng
  text: "Background\r\nBorrelia burgdorferi is a tick-borne spirochete that causes
    Lyme borreliosis (LB). After an initial tick bite, it spreads from the deposition
    site in the dermis to distant tissues of the host. It is generally believed that
    this spirochete disseminates via the hematogenous route. Borrelia persica causes
    relapsing fever and is able to replicate in the blood stream. Currently the exact
    dissemination pathway of LB pathogens in the host is not known and controversially
    discussed.\r\nMethods\r\nIn this study, we established a strict intravenous infection
    murine model using host-adapted spirochetes. Survival capacity and infectivity
    of host-adapted B. burgdorferi sensu stricto (Bbss) were compared to those of
    B. persica (Bp) after either intradermal (ID) injection into the dorsal skin of
    immunocompetent mice or strict intravenous (IV) inoculation via the jugular vein.
    By in vitro culture and PCR, viable spirochetes and their DNA load in peripheral
    blood were periodically monitored during a 49/50-day course post-injection, as
    well as in various tissue samples collected at day 49/50. Specific antibodies
    in individual plasma/serum samples were detected with serological methods.\r\nResults\r\nRegardless
    of ID or IV injection, DNA of Bp was present in blood samples up to day 24 post-challenge,
    while no Bbss was detectable in the blood circulation during the complete observation
    period. In contrast to the brain tropism of Bp, Bbss spirochetes were found in
    ear, skin, joint, bladder, and heart tissue samples of only ID-inoculated mice.
    All tested tissues collected from IV-challenged mice were negative for traces
    of Bbss. ELISA testing of serum samples showed that Bp induced gradually increasing
    antibody levels after ID or IV inoculation, while Bbss did so only after ID injection
    but not after IV inoculation.\r\nConclusions\r\nThis study allows us to draw the
    following conclusions: (i) Bp survives in the blood and disseminates to the host’s
    brain via the hematogenous route; and (ii) Bbss, in contrast, is cleared rapidly
    from the blood stream and is a tissue-bound spirochete."
article_number: '191'
author:
- first_name: Liucun
  full_name: Liang, Liucun
  last_name: Liang
- first_name: Jinyong
  full_name: Wang, Jinyong
  last_name: Wang
- first_name: Lucas
  full_name: Schorter, Lucas
  last_name: Schorter
- first_name: Thu Phong
  full_name: Nguyen Trong, Thu Phong
  last_name: Nguyen Trong
- first_name: Shari
  full_name: Fell, Shari
  last_name: Fell
- first_name: Sebastian
  full_name: Ulrich, Sebastian
  id: '85847'
  last_name: Ulrich
  orcid: 0000-0002-4511-9537
- first_name: Reinhard K.
  full_name: Straubinger, Reinhard K.
  last_name: Straubinger
citation:
  ama: Liang L, Wang J, Schorter L, et al. Rapid clearance of Borrelia burgdorferi
    from the blood circulation. <i>Parasites &#38; vectors</i>. 2020;13(1). doi:<a
    href="https://doi.org/10.1186/s13071-020-04060-y">10.1186/s13071-020-04060-y</a>
  apa: Liang, L., Wang, J., Schorter, L., Nguyen Trong, T. P., Fell, S., Ulrich, S.,
    &#38; Straubinger, R. K. (2020). Rapid clearance of Borrelia burgdorferi from
    the blood circulation. <i>Parasites &#38; Vectors</i>, <i>13</i>(1), Article 191.
    <a href="https://doi.org/10.1186/s13071-020-04060-y">https://doi.org/10.1186/s13071-020-04060-y</a>
  bjps: <b>Liang L <i>et al.</i></b> (2020) Rapid Clearance of Borrelia Burgdorferi
    from the Blood Circulation. <i>Parasites &#38; vectors</i> <b>13</b>.
  chicago: Liang, Liucun, Jinyong Wang, Lucas Schorter, Thu Phong Nguyen Trong, Shari
    Fell, Sebastian Ulrich, and Reinhard K. Straubinger. “Rapid Clearance of Borrelia
    Burgdorferi from the Blood Circulation.” <i>Parasites &#38; Vectors</i> 13, no.
    1 (2020). <a href="https://doi.org/10.1186/s13071-020-04060-y">https://doi.org/10.1186/s13071-020-04060-y</a>.
  chicago-de: Liang, Liucun, Jinyong Wang, Lucas Schorter, Thu Phong Nguyen Trong,
    Shari Fell, Sebastian Ulrich und Reinhard K. Straubinger. 2020. Rapid clearance
    of Borrelia burgdorferi from the blood circulation. <i>Parasites &#38; vectors</i>
    13, Nr. 1. doi:<a href="https://doi.org/10.1186/s13071-020-04060-y">10.1186/s13071-020-04060-y</a>,
    .
  din1505-2-1: '<span style="font-variant:small-caps;">Liang, Liucun</span> ; <span
    style="font-variant:small-caps;">Wang, Jinyong</span> ; <span style="font-variant:small-caps;">Schorter,
    Lucas</span> ; <span style="font-variant:small-caps;">Nguyen Trong, Thu Phong</span>
    ; <span style="font-variant:small-caps;">Fell, Shari</span> ; <span style="font-variant:small-caps;">Ulrich,
    Sebastian</span> ; <span style="font-variant:small-caps;">Straubinger, Reinhard
    K.</span>: Rapid clearance of Borrelia burgdorferi from the blood circulation.
    In: <i>Parasites &#38; vectors</i> Bd. 13. London, BioMed Central  (2020), Nr. 1'
  havard: L. Liang, J. Wang, L. Schorter, T.P. Nguyen Trong, S. Fell, S. Ulrich, R.K.
    Straubinger, Rapid clearance of Borrelia burgdorferi from the blood circulation,
    Parasites &#38; Vectors. 13 (2020).
  ieee: 'L. Liang <i>et al.</i>, “Rapid clearance of Borrelia burgdorferi from the
    blood circulation,” <i>Parasites &#38; vectors</i>, vol. 13, no. 1, Art. no. 191,
    2020, doi: <a href="https://doi.org/10.1186/s13071-020-04060-y">10.1186/s13071-020-04060-y</a>.'
  mla: Liang, Liucun, et al. “Rapid Clearance of Borrelia Burgdorferi from the Blood
    Circulation.” <i>Parasites &#38; Vectors</i>, vol. 13, no. 1, 191, 2020, <a href="https://doi.org/10.1186/s13071-020-04060-y">https://doi.org/10.1186/s13071-020-04060-y</a>.
  short: L. Liang, J. Wang, L. Schorter, T.P. Nguyen Trong, S. Fell, S. Ulrich, R.K.
    Straubinger, Parasites &#38; Vectors 13 (2020).
  ufg: '<b>Liang, Liucun u. a.</b>: Rapid clearance of Borrelia burgdorferi from the
    blood circulation, in: <i>Parasites &#38; vectors</i> 13 (2020), H. 1.'
  van: Liang L, Wang J, Schorter L, Nguyen Trong TP, Fell S, Ulrich S, et al. Rapid
    clearance of Borrelia burgdorferi from the blood circulation. Parasites &#38;
    vectors. 2020;13(1).
date_created: 2025-06-15T10:13:30Z
date_updated: 2025-06-17T14:17:27Z
department:
- _id: DEP4010
doi: 10.1186/s13071-020-04060-y
extern: '1'
intvolume: '        13'
issue: '1'
keyword:
- Lyme borreliosis
- Borrelia burgdorferi
- Tick-borne relapsing fever
- Borrelia persica
- Blood clearance
language:
- iso: eng
place: London
publication: Parasites & vectors
publication_identifier:
  issn:
  - 1756-3305
publication_status: published
publisher: 'BioMed Central '
quality_controlled: '1'
status: public
title: Rapid clearance of Borrelia burgdorferi from the blood circulation
type: scientific_journal_article
user_id: '83781'
volume: 13
year: '2020'
...
---
_id: '12963'
abstract:
- lang: eng
  text: The genus Borrelia comprises vector-borne bacterial pathogens that can severely
    affect human and animal health. Members of the Borrelia burgdorferi sensu lato
    species complex can cause Lyme borreliosis, one of the most common vector-borne
    diseases in the Northern hemisphere. Besides, members of the relapsing fever group
    of spirochetes can cause tick-borne relapsing fever in humans and various febrile
    illnesses in animals in tropical, subtropical and temperate regions. Borrelia
    spp. organisms are fastidious to cultivate and to maintain in vitro, and therefore,
    difficult to work with in the laboratory. Currently, borrelia identification is
    mainly performed using PCR and DNA sequencing methods, which can be complicated/frustrating
    on complex DNA templates and may still be relatively expensive. Alternative techniques
    such as matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    (MALDI-TOF MS) are not well established for Borrelia spp., although this technique
    is currently one of the most used techniques for rapid identification of bacteria
    in microbiological diagnostic laboratories. This is mainly due to unsatisfactory
    results obtained by use of simple sample preparation techniques and medium-contamination
    obscuring the mass spectra. In addition, comprehensive libraries for Borrelia
    spp. MALDI-TOF MS have yet to be established. In this study, we developed a new
    filter-based chemical extraction technique that allows measurement of high quality
    Borrelia spp. spectra from less than 100,000 bacteria per spot in MALDI-TOF MS.
    We used 49 isolates of 13 different species to produce the largest mass-library
    for Borrelia spp. so far and to validate the protocol. The library was successfully
    established and identifies >96% of used isolates correctly to species level. Cluster
    analysis on the sum spectra was applied to all the different isolates, which resulted
    in tight cluster generation for most species. Comparative analysis of the generated
    cluster to a phylogeny based on concatenated multi-locus sequence typing genes
    provided a surprising homology. Our data demonstrate that the technique described
    here can be used for fast and reliable species and strain typing within the borrelia
    complex.
author:
- first_name: Anna-Cathrine
  full_name: Neumann-Cip, Anna-Cathrine
  last_name: Neumann-Cip
- first_name: Volker
  full_name: Fingerle, Volker
  last_name: Fingerle
- first_name: Gabriele
  full_name: Margos, Gabriele
  last_name: Margos
- first_name: Reinhard K.
  full_name: Straubinger, Reinhard K.
  last_name: Straubinger
- first_name: Evelyn
  full_name: Overzier, Evelyn
  last_name: Overzier
- first_name: Sebastian
  full_name: Ulrich, Sebastian
  id: '85847'
  last_name: Ulrich
  orcid: 0000-0002-4511-9537
- first_name: Andreas
  full_name: Wieser, Andreas
  last_name: Wieser
citation:
  ama: Neumann-Cip AC, Fingerle V, Margos G, et al. A Novel Rapid Sample Preparation
    Method for MALDI-TOF MS Permits Borrelia burgdorferi Sensu Lato Species and Isolate
    Differentiation. <i>Frontiers in Microbiology</i>. 2020;11. doi:<a href="https://doi.org/10.3389/fmicb.2020.00690">10.3389/fmicb.2020.00690</a>
  apa: Neumann-Cip, A.-C., Fingerle, V., Margos, G., Straubinger, R. K., Overzier,
    E., Ulrich, S., &#38; Wieser, A. (2020). A Novel Rapid Sample Preparation Method
    for MALDI-TOF MS Permits Borrelia burgdorferi Sensu Lato Species and Isolate Differentiation.
    <i>Frontiers in Microbiology</i>, <i>11</i>. <a href="https://doi.org/10.3389/fmicb.2020.00690">https://doi.org/10.3389/fmicb.2020.00690</a>
  bjps: <b>Neumann-Cip A-C <i>et al.</i></b> (2020) A Novel Rapid Sample Preparation
    Method for MALDI-TOF MS Permits Borrelia Burgdorferi Sensu Lato Species and Isolate
    Differentiation. <i>Frontiers in Microbiology</i> <b>11</b>.
  chicago: Neumann-Cip, Anna-Cathrine, Volker Fingerle, Gabriele Margos, Reinhard
    K. Straubinger, Evelyn Overzier, Sebastian Ulrich, and Andreas Wieser. “A Novel
    Rapid Sample Preparation Method for MALDI-TOF MS Permits Borrelia Burgdorferi
    Sensu Lato Species and Isolate Differentiation.” <i>Frontiers in Microbiology</i>
    11 (2020). <a href="https://doi.org/10.3389/fmicb.2020.00690">https://doi.org/10.3389/fmicb.2020.00690</a>.
  chicago-de: Neumann-Cip, Anna-Cathrine, Volker Fingerle, Gabriele Margos, Reinhard
    K. Straubinger, Evelyn Overzier, Sebastian Ulrich und Andreas Wieser. 2020. A
    Novel Rapid Sample Preparation Method for MALDI-TOF MS Permits Borrelia burgdorferi
    Sensu Lato Species and Isolate Differentiation. <i>Frontiers in Microbiology</i>
    11. doi:<a href="https://doi.org/10.3389/fmicb.2020.00690">10.3389/fmicb.2020.00690</a>,
    .
  din1505-2-1: '<span style="font-variant:small-caps;">Neumann-Cip, Anna-Cathrine</span>
    ; <span style="font-variant:small-caps;">Fingerle, Volker</span> ; <span style="font-variant:small-caps;">Margos,
    Gabriele</span> ; <span style="font-variant:small-caps;">Straubinger, Reinhard
    K.</span> ; <span style="font-variant:small-caps;">Overzier, Evelyn</span> ; <span
    style="font-variant:small-caps;">Ulrich, Sebastian</span> ; <span style="font-variant:small-caps;">Wieser,
    Andreas</span>: A Novel Rapid Sample Preparation Method for MALDI-TOF MS Permits
    Borrelia burgdorferi Sensu Lato Species and Isolate Differentiation. In: <i>Frontiers
    in Microbiology</i> Bd. 11. Lausanne, Frontiers Media SA (2020)'
  havard: A.-C. Neumann-Cip, V. Fingerle, G. Margos, R.K. Straubinger, E. Overzier,
    S. Ulrich, A. Wieser, A Novel Rapid Sample Preparation Method for MALDI-TOF MS
    Permits Borrelia burgdorferi Sensu Lato Species and Isolate Differentiation, Frontiers
    in Microbiology. 11 (2020).
  ieee: 'A.-C. Neumann-Cip <i>et al.</i>, “A Novel Rapid Sample Preparation Method
    for MALDI-TOF MS Permits Borrelia burgdorferi Sensu Lato Species and Isolate Differentiation,”
    <i>Frontiers in Microbiology</i>, vol. 11, 2020, doi: <a href="https://doi.org/10.3389/fmicb.2020.00690">10.3389/fmicb.2020.00690</a>.'
  mla: Neumann-Cip, Anna-Cathrine, et al. “A Novel Rapid Sample Preparation Method
    for MALDI-TOF MS Permits Borrelia Burgdorferi Sensu Lato Species and Isolate Differentiation.”
    <i>Frontiers in Microbiology</i>, vol. 11, 2020, <a href="https://doi.org/10.3389/fmicb.2020.00690">https://doi.org/10.3389/fmicb.2020.00690</a>.
  short: A.-C. Neumann-Cip, V. Fingerle, G. Margos, R.K. Straubinger, E. Overzier,
    S. Ulrich, A. Wieser, Frontiers in Microbiology 11 (2020).
  ufg: '<b>Neumann-Cip, Anna-Cathrine u. a.</b>: A Novel Rapid Sample Preparation
    Method for MALDI-TOF MS Permits Borrelia burgdorferi Sensu Lato Species and Isolate
    Differentiation, in: <i>Frontiers in Microbiology</i> 11 (2020).'
  van: Neumann-Cip AC, Fingerle V, Margos G, Straubinger RK, Overzier E, Ulrich S,
    et al. A Novel Rapid Sample Preparation Method for MALDI-TOF MS Permits Borrelia
    burgdorferi Sensu Lato Species and Isolate Differentiation. Frontiers in Microbiology.
    2020;11.
date_created: 2025-06-15T10:15:09Z
date_updated: 2025-06-18T11:09:40Z
department:
- _id: DEP4010
doi: 10.3389/fmicb.2020.00690
extern: '1'
intvolume: '        11'
keyword:
- Borrelia burgdorferi sensu lato
- MALDI-TOF MS
- typing
- sample preparation
- MALDI-TOF MS library
- strain typing
- automatic identification
language:
- iso: eng
place: Lausanne
publication: Frontiers in Microbiology
publication_identifier:
  eissn:
  - 1664-302X
publication_status: published
publisher: Frontiers Media SA
quality_controlled: '1'
status: public
title: A Novel Rapid Sample Preparation Method for MALDI-TOF MS Permits Borrelia burgdorferi
  Sensu Lato Species and Isolate Differentiation
type: scientific_journal_article
user_id: '83781'
volume: 11
year: '2020'
...
---
_id: '12964'
abstract:
- lang: eng
  text: Antibodies represent an important element in the adaptive immune response
    and a major tool to eliminate microbial pathogens. For many bacterial and viral
    infections, efficient vaccines exist, but not for fungal pathogens. For a long
    time, antibodies have been assumed to be of minor importance for a successful
    clearance of fungal infections; however this perception has been challenged by
    a large number of studies over the last three decades. In this review, we focus
    on the potential therapeutic and prophylactic use of monoclonal antibodies. Since
    systemic mycoses normally occur in severely immunocompromised patients, a passive
    immunization using monoclonal antibodies is a promising approach to directly attack
    the fungal pathogen and/or to activate and strengthen the residual antifungal
    immune response in these patients.
article_number: '22'
author:
- first_name: Sebastian
  full_name: Ulrich, Sebastian
  id: '85847'
  last_name: Ulrich
  orcid: 0000-0002-4511-9537
- first_name: Frank
  full_name: Ebel, Frank
  last_name: Ebel
citation:
  ama: Ulrich S, Ebel F. Monoclonal Antibodies as Tools to Combat Fungal Infections.
    <i>Journal of Fungi</i>. 2020;6(1). doi:<a href="https://doi.org/10.3390/jof6010022">10.3390/jof6010022</a>
  apa: Ulrich, S., &#38; Ebel, F. (2020). Monoclonal Antibodies as Tools to Combat
    Fungal Infections. <i>Journal of Fungi</i>, <i>6</i>(1), Article 22. <a href="https://doi.org/10.3390/jof6010022">https://doi.org/10.3390/jof6010022</a>
  bjps: <b>Ulrich S and Ebel F</b> (2020) Monoclonal Antibodies as Tools to Combat
    Fungal Infections. <i>Journal of Fungi</i> <b>6</b>.
  chicago: Ulrich, Sebastian, and Frank Ebel. “Monoclonal Antibodies as Tools to Combat
    Fungal Infections.” <i>Journal of Fungi</i> 6, no. 1 (2020). <a href="https://doi.org/10.3390/jof6010022">https://doi.org/10.3390/jof6010022</a>.
  chicago-de: Ulrich, Sebastian und Frank Ebel. 2020. Monoclonal Antibodies as Tools
    to Combat Fungal Infections. <i>Journal of Fungi</i> 6, Nr. 1. doi:<a href="https://doi.org/10.3390/jof6010022">10.3390/jof6010022</a>,
    .
  din1505-2-1: '<span style="font-variant:small-caps;">Ulrich, Sebastian</span> ;
    <span style="font-variant:small-caps;">Ebel, Frank</span>: Monoclonal Antibodies
    as Tools to Combat Fungal Infections. In: <i>Journal of Fungi</i> Bd. 6. Basel,
    MDPI  (2020), Nr. 1'
  havard: S. Ulrich, F. Ebel, Monoclonal Antibodies as Tools to Combat Fungal Infections,
    Journal of Fungi. 6 (2020).
  ieee: 'S. Ulrich and F. Ebel, “Monoclonal Antibodies as Tools to Combat Fungal Infections,”
    <i>Journal of Fungi</i>, vol. 6, no. 1, Art. no. 22, 2020, doi: <a href="https://doi.org/10.3390/jof6010022">10.3390/jof6010022</a>.'
  mla: Ulrich, Sebastian, and Frank Ebel. “Monoclonal Antibodies as Tools to Combat
    Fungal Infections.” <i>Journal of Fungi</i>, vol. 6, no. 1, 22, 2020, <a href="https://doi.org/10.3390/jof6010022">https://doi.org/10.3390/jof6010022</a>.
  short: S. Ulrich, F. Ebel, Journal of Fungi 6 (2020).
  ufg: '<b>Ulrich, Sebastian/Ebel, Frank</b>: Monoclonal Antibodies as Tools to Combat
    Fungal Infections, in: <i>Journal of Fungi</i> 6 (2020), H. 1.'
  van: Ulrich S, Ebel F. Monoclonal Antibodies as Tools to Combat Fungal Infections.
    Journal of Fungi. 2020;6(1).
date_created: 2025-06-15T10:17:00Z
date_updated: 2025-06-18T11:13:40Z
department:
- _id: DEP4010
doi: 10.3390/jof6010022
extern: '1'
intvolume: '         6'
issue: '1'
keyword:
- monoclonal antibodies
- invasive fungal infections
- therapy
- prophylaxis
- opsonization
language:
- iso: eng
place: Basel
publication: Journal of Fungi
publication_identifier:
  eissn:
  - 2309-608X
publication_status: published
publisher: 'MDPI '
quality_controlled: '1'
status: public
title: Monoclonal Antibodies as Tools to Combat Fungal Infections
type: scientific_journal_article
user_id: '83781'
volume: 6
year: '2020'
...
