---
_id: '12964'
abstract:
- lang: eng
text: Antibodies represent an important element in the adaptive immune response
and a major tool to eliminate microbial pathogens. For many bacterial and viral
infections, efficient vaccines exist, but not for fungal pathogens. For a long
time, antibodies have been assumed to be of minor importance for a successful
clearance of fungal infections; however this perception has been challenged by
a large number of studies over the last three decades. In this review, we focus
on the potential therapeutic and prophylactic use of monoclonal antibodies. Since
systemic mycoses normally occur in severely immunocompromised patients, a passive
immunization using monoclonal antibodies is a promising approach to directly attack
the fungal pathogen and/or to activate and strengthen the residual antifungal
immune response in these patients.
article_number: '22'
author:
- first_name: Sebastian
full_name: Ulrich, Sebastian
id: '85847'
last_name: Ulrich
orcid: 0000-0002-4511-9537
- first_name: Frank
full_name: Ebel, Frank
last_name: Ebel
citation:
ama: Ulrich S, Ebel F. Monoclonal Antibodies as Tools to Combat Fungal Infections.
Journal of Fungi. 2020;6(1). doi:10.3390/jof6010022
apa: Ulrich, S., & Ebel, F. (2020). Monoclonal Antibodies as Tools to Combat
Fungal Infections. Journal of Fungi, 6(1), Article 22. https://doi.org/10.3390/jof6010022
bjps: Ulrich S and Ebel F (2020) Monoclonal Antibodies as Tools to Combat
Fungal Infections. Journal of Fungi 6.
chicago: Ulrich, Sebastian, and Frank Ebel. “Monoclonal Antibodies as Tools to Combat
Fungal Infections.” Journal of Fungi 6, no. 1 (2020). https://doi.org/10.3390/jof6010022.
chicago-de: Ulrich, Sebastian und Frank Ebel. 2020. Monoclonal Antibodies as Tools
to Combat Fungal Infections. Journal of Fungi 6, Nr. 1. doi:10.3390/jof6010022,
.
din1505-2-1: 'Ulrich, Sebastian ;
Ebel, Frank: Monoclonal Antibodies
as Tools to Combat Fungal Infections. In: Journal of Fungi Bd. 6. Basel,
MDPI (2020), Nr. 1'
havard: S. Ulrich, F. Ebel, Monoclonal Antibodies as Tools to Combat Fungal Infections,
Journal of Fungi. 6 (2020).
ieee: 'S. Ulrich and F. Ebel, “Monoclonal Antibodies as Tools to Combat Fungal Infections,”
Journal of Fungi, vol. 6, no. 1, Art. no. 22, 2020, doi: 10.3390/jof6010022.'
mla: Ulrich, Sebastian, and Frank Ebel. “Monoclonal Antibodies as Tools to Combat
Fungal Infections.” Journal of Fungi, vol. 6, no. 1, 22, 2020, https://doi.org/10.3390/jof6010022.
short: S. Ulrich, F. Ebel, Journal of Fungi 6 (2020).
ufg: 'Ulrich, Sebastian/Ebel, Frank: Monoclonal Antibodies as Tools to Combat
Fungal Infections, in: Journal of Fungi 6 (2020), H. 1.'
van: Ulrich S, Ebel F. Monoclonal Antibodies as Tools to Combat Fungal Infections.
Journal of Fungi. 2020;6(1).
date_created: 2025-06-15T10:17:00Z
date_updated: 2025-06-18T11:13:40Z
department:
- _id: DEP4010
doi: 10.3390/jof6010022
extern: '1'
intvolume: ' 6'
issue: '1'
keyword:
- monoclonal antibodies
- invasive fungal infections
- therapy
- prophylaxis
- opsonization
language:
- iso: eng
place: Basel
publication: Journal of Fungi
publication_identifier:
eissn:
- 2309-608X
publication_status: published
publisher: 'MDPI '
quality_controlled: '1'
status: public
title: Monoclonal Antibodies as Tools to Combat Fungal Infections
type: scientific_journal_article
user_id: '83781'
volume: 6
year: '2020'
...
---
_id: '13372'
abstract:
- lang: eng
text: "This bachelor thesis explores the adaptive reuse of the former Telekom high-rise
at Kesselbrink in Bielefeld, a vacant modernist office tower awaiting new purpose.
The project proposes a mixed-use transformation that reinterprets the building
as a “city within the city,” inspired by Le Corbusier’s Unité d’Habitation in
Marseille. The existing structure is strategically reduced to its essential load-bearing
concrete frame and floor slabs, preserving the structural skeleton while enabling
radical spatial reconfiguration.\r\nPrefabricated timber modules are inserted
and cantilevered between the reinforced-concrete columns, extending the usable
floor area and introducing a warm, contemporary material contrast to the original
façade. This intervention not only increases density and flexibility but also
redefines the tower’s appearance, giving it a cosmopolitan and forward-looking
architectural identity. The ground floor is conceived as an open and publicly
accessible urban platform, activating the surrounding plaza and strengthening
social interaction. Upper floors are redesigned as affordable and attractive living
spaces for young residents, encouraging a diverse and vibrant community within
the building.\r\nA newly designed park-like rooftop landscape provides recreational
space and panoramic views over the city, enhancing environmental quality and urban
connectivity. By combining structural preservation, modular timber construction,
public programming, and residential reuse, the proposal demonstrates how high-rise
retrofitting can generate social, ecological, and economic value simultaneously.
The project positions adaptive reuse as a viable strategy for sustainable urban
regeneration and architectural longevity."
author:
- first_name: Leon
full_name: Konschake, Leon
id: '84541'
last_name: Konschake
orcid: https://orcid.org/0009-0000-5181-1573
citation:
ama: Konschake L. TreeTower. Technische Hochschule Ostwestfalen-Lippe; 2020.
apa: Konschake, L. (2020). TreeTower. Technische Hochschule Ostwestfalen-Lippe.
bjps: 'Konschake L (2020) TreeTower. Detmolder Schule für Gestaltung:
Technische Hochschule Ostwestfalen-Lippe.'
chicago: 'Konschake, Leon. TreeTower. Detmolder Schule für Gestaltung: Technische
Hochschule Ostwestfalen-Lippe, 2020.'
chicago-de: 'Konschake, Leon. 2020. TreeTower. Detmolder Schule für Gestaltung:
Technische Hochschule Ostwestfalen-Lippe.'
din1505-2-1: 'Konschake, Leon: TreeTower.
Detmolder Schule für Gestaltung : Technische Hochschule Ostwestfalen-Lippe, 2020'
havard: L. Konschake, TreeTower, Technische Hochschule Ostwestfalen-Lippe, Detmolder
Schule für Gestaltung, 2020.
ieee: 'L. Konschake, TreeTower. Detmolder Schule für Gestaltung: Technische
Hochschule Ostwestfalen-Lippe, 2020.'
mla: Konschake, Leon. TreeTower. Technische Hochschule Ostwestfalen-Lippe,
2020.
short: L. Konschake, TreeTower, Technische Hochschule Ostwestfalen-Lippe, Detmolder
Schule für Gestaltung, 2020.
ufg: 'Konschake, Leon: TreeTower, Detmolder Schule für Gestaltung 2020.'
van: 'Konschake L. TreeTower. Detmolder Schule für Gestaltung: Technische Hochschule
Ostwestfalen-Lippe; 2020.'
date_created: 2026-02-12T11:47:28Z
date_updated: 2026-02-20T07:09:36Z
department:
- _id: DEP1600
extern: '1'
keyword:
- Adaptive Reuse
- Mixed-Use Development
- High-Rise Transformation
- City within the City
- Modular Timber Construction
- Prefabrication
- Structural Preservation
- Concrete Skeleton
- Cantilevered Modules
- Urban Regeneration
- Public Ground Floor
- Youth Housing
- Rooftop Landscape
- Sustainability
- Social Impact
- Ecological Design
- Economic Viability
- Cosmopolitan Architecture
language:
- iso: eng
place: Detmolder Schule für Gestaltung
publication_status: published
publisher: Technische Hochschule Ostwestfalen-Lippe
status: public
supervisor:
- first_name: Hans
full_name: Sachs, Hans
id: '64589'
last_name: Sachs
title: TreeTower
type: bachelor_thesis
user_id: '83781'
year: '2020'
...