---
res:
  bibo_abstract:
  - Glove occlusion might enhance skin sensitivity to a subsequent detergent challenge
    (occlusion effect). Thus, some skin protection creams (PC) claim to protect against
    this effect of occlusion, and are recommended to be used before wearing liquid‐proof
    gloves.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>To
    evaluate the effect of PC applied prior to glove occlusion on the ‘occlusion effect’—refers
    to increased susceptibility of the skin to a model detergent.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>One
    hundred and eleven volunteers were enrolled in a single‐blind, randomized study.
    Seven PCs were applied before glove occlusion over 7 days (D1–D7). After sodium
    lauryl sulphate (SLS) challenge, we compared the irritation between the areas
    treated with PC and occlusion alone. Clinical scoring and bioengineering methods
    (capacitance, transepidermal water loss [TEWL], and colourimetry [erythema]) were
    used to quantify the irritant reactions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>After
    1 week of occlusion and PC application, we did not observe significant changes
    in TEWL, nor in erythema, whereas skin hydration raised in three cream‐treated
    areas. On day 10, after a challenge with SLS, some products significantly aggravated
    the skin irritation as compared to occlusion alone.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The
    ‘occlusion effect’—shown as higher skin susceptibility to a model detergent—was
    not mitigated by PCs when applied prior to glove occlusion. On the contrary, some
    PCs might have negative effects on skin barrier function and augment such sensitivity.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Michal
      foaf_name: Gina, Michal
      foaf_surname: Gina
  - foaf_Person:
      foaf_givenName: Katharina
      foaf_name: Wichert, Katharina
      foaf_surname: Wichert
  - foaf_Person:
      foaf_givenName: Gerd
      foaf_name: Kutz, Gerd
      foaf_surname: Kutz
      foaf_workInfoHomepage: http://www.librecat.org/personId=12015
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Brüning, Thomas
      foaf_surname: Brüning
  - foaf_Person:
      foaf_givenName: Manigé
      foaf_name: Fartasch, Manigé
      foaf_surname: Fartasch
  bibo_doi: 10.1111/cod.14287
  bibo_issue: '5'
  bibo_volume: 88
  dct_date: 2023^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0105-1873
  - http://id.crossref.org/issn/1600-0536
  dct_language: eng
  dct_publisher: Wiley@
  dct_subject:
  - barrier disturbance
  - glove occlusion
  - irritant contact dermatitis
  - irritation
  - non-invasive measuring methods
  - occupational contact dermatitis
  - skin barrier disturbance
  - skin protective cream
  - wet work.
  dct_title: Applying skin protective cream and the wearing of gloves?—A randomized
    controlled experimental study@
  fabio_hasPubmedId: '36727715'
...