{"citation":{"chicago":"Babczyk, Patrick, Ulrich Odefey, and Edda Tobiasch. <i>Testing the Potency of Extracellular Vesicles Derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay</i>, 2024.","ieee":"P. Babczyk, U. Odefey, and E. Tobiasch, <i>Testing the Potency of Extracellular Vesicles derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay</i>. 2024.","short":"P. Babczyk, U. Odefey, E. Tobiasch, Testing the Potency of Extracellular Vesicles Derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay, 2024.","bjps":"<b>Babczyk P, Odefey U and Tobiasch E</b> (2024) <i>Testing the Potency of Extracellular Vesicles Derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay</i>. .","havard":"P. Babczyk, U. Odefey, E. Tobiasch, Testing the Potency of Extracellular Vesicles derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay, 2024.","mla":"Babczyk, Patrick, et al. <i>Testing the Potency of Extracellular Vesicles Derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay</i>. 2024.","apa":"Babczyk, P., Odefey, U., &#38; Tobiasch, E. (2024). <i>Testing the Potency of Extracellular Vesicles derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay</i>. 1. Conference on Targeting Extracellular Vesicles, Mitochondria and Microbiota: Crucial Impact, Malta.","ufg":"<b>Babczyk, Patrick/Odefey, Ulrich/Tobiasch, Edda</b>: Testing the Potency of Extracellular Vesicles derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay, o. O. 2024.","chicago-de":"Babczyk, Patrick, Ulrich Odefey und Edda Tobiasch. 2024. <i>Testing the Potency of Extracellular Vesicles derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay</i>.","van":"Babczyk P, Odefey U, Tobiasch E. Testing the Potency of Extracellular Vesicles derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay. 2024.","ama":"Babczyk P, Odefey U, Tobiasch E. <i>Testing the Potency of Extracellular Vesicles Derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay</i>.; 2024.","din1505-2-1":"<span style=\"font-variant:small-caps;\">Babczyk, Patrick</span> ; <span style=\"font-variant:small-caps;\">Odefey, Ulrich</span> ; <span style=\"font-variant:small-caps;\">Tobiasch, Edda</span>: <i>Testing the Potency of Extracellular Vesicles derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay</i>, 2024"},"status":"public","_id":"13359","conference":{"location":"Malta","end_date":"2024-10-18","name":"1. Conference on Targeting Extracellular Vesicles, Mitochondria and Microbiota: Crucial Impact","start_date":"2024-10-17"},"date_updated":"2026-02-10T12:33:36Z","year":"2024","title":"Testing the Potency of Extracellular Vesicles derived from Differentiating Mesenchymal Stem Cells with an Adapted Wound Assay","abstract":[{"text":"Extracellular vesicles (EVs) have been recognized as major signaling mediators in a variety of physiological and pathophysiological conditions. Their paracrine effects are promoted via bioactive molecules. However an essential first step before a potential application of EVs in regenerative medicine is a batch-to-batch reproducibility of their therapeutic efficacy. For this a qualitative and quantitative testing of their potency is a necessary step. An adapted in vitro wound assay will be presented using a newly developed scratch machine and a computational-aided read-out. One of the major reasons for the onset of arteries clotting is gaining weight. During the development towards adipocytes, differentiating mesenchymal stem cells are highly metabolically active, which can activate primary endothelial cells (ECs).This is a crucial first step towards artery clotting. These activated ECs migrate in the adapted wound assay, which can be evaluated. We are able to count quantitatively the migrated ECs, monitor their migration behavior, e.g. speed, and isolate the migrated ECs to investigate their altered signal transduction pathways by comparing them with the non-migrating ECs. By evaluating the migration behavior, we record functional testing of EV potency, which was better than what could be archived using a Boyden Chamber.","lang":"eng"}],"publication_status":"published","language":[{"iso":"eng"}],"department":[{"_id":"DEP4028"}],"date_created":"2026-02-05T13:13:46Z","type":"conference_speech","user_id":"83781","author":[{"last_name":"Babczyk","full_name":"Babczyk, Patrick","first_name":"Patrick"},{"first_name":"Ulrich","id":"74218","full_name":"Odefey, Ulrich","last_name":"Odefey"},{"full_name":"Tobiasch, Edda","last_name":"Tobiasch","first_name":"Edda"}]}