Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys chartarum

K. Tribelhorn, M. Twarużek, E. Soszczyńska, J. Rau, C. Baschien, R.K. Straubinger, F. Ebel, S. Ulrich, Toxins 14 (2022).

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Zeitschriftenaufsatz (wiss.) | Veröffentlicht | Englisch
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Abstract
Stachybotrys chartarum is a toxigenic fungus that is frequently isolated from damp building materials or improperly stored forage. Macrocyclic trichothecenes and in particular satratoxins are the most potent mycotoxins known to be produced by this fungus. Exposure of humans or animals to these secondary metabolites can be associated with severe health problems. To assess the pathogenic potential of S. chartarum isolates, it is essential to cultivate them under conditions that reliably promote toxin production. Potato dextrose agar (PDA) was reported to be the optimal nutrition medium for satratoxin production. In this study, the growth of S. chartarum genotype S strains on PDA from two manufacturers led to divergent results, namely, well-grown and sporulating cultures with high satratoxin concentrations (20.8 ± 0.4 µg/cm2) versus cultures with sparse sporulation and low satratoxin production (0.3 ± 0.1 µg/cm2). This finding is important for any attempt to identify toxigenic S. chartarum isolates. Further experiments performed with the two media provided strong evidence for a link between satratoxin production and sporulation. A comparison of three-point and one-point cultures grown on the two types of PDA, furthermore, demonstrated an inter-colony communication that influences both sporulation and mycotoxin production of S. chartarum genotype S strains.
Erscheinungsjahr
Zeitschriftentitel
Toxins
Band
14
Zeitschriftennummer
8
Artikelnummer
515
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Tribelhorn K, Twarużek M, Soszczyńska E, et al. Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys chartarum. Toxins. 2022;14(8). doi:10.3390/toxins14080515
Tribelhorn, K., Twarużek, M., Soszczyńska, E., Rau, J., Baschien, C., Straubinger, R. K., Ebel, F., & Ulrich, S. (2022). Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys chartarum. Toxins, 14(8), Article 515. https://doi.org/10.3390/toxins14080515
Tribelhorn K et al. (2022) Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys Chartarum. Toxins 14.
Tribelhorn, Katharina, Magdalena Twarużek, Ewelina Soszczyńska, Jörg Rau, Christiane Baschien, Reinhard K. Straubinger, Frank Ebel, and Sebastian Ulrich. “Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys Chartarum.” Toxins 14, no. 8 (2022). https://doi.org/10.3390/toxins14080515.
Tribelhorn, Katharina, Magdalena Twarużek, Ewelina Soszczyńska, Jörg Rau, Christiane Baschien, Reinhard K. Straubinger, Frank Ebel und Sebastian Ulrich. 2022. Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys chartarum. Toxins 14, Nr. 8. doi:10.3390/toxins14080515, .
Tribelhorn, Katharina ; Twarużek, Magdalena ; Soszczyńska, Ewelina ; Rau, Jörg ; Baschien, Christiane ; Straubinger, Reinhard K. ; Ebel, Frank ; Ulrich, Sebastian: Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys chartarum. In: Toxins Bd. 14, MDPI (2022), Nr. 8
K. Tribelhorn, M. Twarużek, E. Soszczyńska, J. Rau, C. Baschien, R.K. Straubinger, F. Ebel, S. Ulrich, Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys chartarum, Toxins. 14 (2022).
K. Tribelhorn et al., “Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys chartarum,” Toxins, vol. 14, no. 8, Art. no. 515, 2022, doi: 10.3390/toxins14080515.
Tribelhorn, Katharina, et al. “Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys Chartarum.” Toxins, vol. 14, no. 8, 515, 2022, https://doi.org/10.3390/toxins14080515.
Tribelhorn, Katharina u. a.: Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys chartarum, in: Toxins 14 (2022), H. 8.
Tribelhorn K, Twarużek M, Soszczyńska E, Rau J, Baschien C, Straubinger RK, et al. Production of Satratoxin G and H Is Tightly Linked to Sporulation in Stachybotrys chartarum. Toxins. 2022;14(8).

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