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140 Publikationen
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
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2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez, T., Frahm, B., & Posch, C. (2020). Integration of prior knowledge and digital tools for uncertainty-based decision support. Presented at the 1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable, Sandoz, Austria.
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2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1225 – 1226). Wiley. https://doi.org/10.1002/cite.202055235
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| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1241 – 1242). Wiley. https://doi.org/10.1002/cite.202055234
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| DOI
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 |

Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, C., Pörtner, R., & Frahm, B. (2019). Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering, 116(11), 2944–2959. https://doi.org/10.1002/bit.27125
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2019 | Konferenzband - Beitrag | ELSA-ID: 2400
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Multivariable control strategy for the photosynthetic cultures of microalgae. 2019 23rd International Conference on System Theory, Control and Computing (ICSTCC). IEEE. https://doi.org/10.1109/icstcc.2019.8886109
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2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller, J., Müller, J., Hernández Rodriguez, T., Kuchemüller, K. B., Arndt, L., Frahm, B., … Pörtner, R. (2019). Workflow for model-assisted design and scale-up of biopharmaceutical production processes. Presented at the BioTech 2019 - Biopharmaceutical Manufacturing and Single-Use Technologies: Process intensification and continuous bioprocessing with single-use devices, Wädenswil, Switzerland.
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2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller, J., Kuchemüller, K. B., Moser, A., Hass, V. C., Hernández Rodriguez, T., Deppe, S., … Pörtner, R. (2019). Model-Assisted Design of Experiments. Presented at the 5th European Congress of Applied Biotechnology, Florence, Italy.
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2019 | Konferenz - Vortrag | ELSA-ID: 2958
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Novel control strategy for microalgae in photobioreactor. Presented at the 23rd International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the BioProcessingDays 2019, Recklinghausen, Germany.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the 26th Meeting of the European Society for Animal Cell Technology (ESACT): Cell culture technologies: bridging academia and industry to provide solutions for patients, Copenhagen, Denmark.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Deppe, S., Ifrim, G. A., Moser, A., … Pörtner, R. (2019). Model-Assisted Design of Experiments – Software Toolbox. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., Tölle, M., Kuhfuß, F., Möller, J., … Frahm, B. (2019). Model-assisted Design of Experiments for algae cultivation. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2019). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3006
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Multivariable control strategy for the photosynthetic cultures of microalgae. Presented at the 23rd International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania.
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 7928
Frahm, B. (2019). Scale-up of stirred vessels. Presented at the International Week “Welfare and Responsibility,” SeAMK, Seinäjoki, Finnland.
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2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 |

Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Frahm, B., Hass, V. C., & Pörtner, R. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review, 3, 39–41.
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2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2018). Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. BMC Proceedings (Vol. 112, p. P175). Lausanne, Switzerland: BioMed Central. https://doi.org/10.1186/s12919-018-0097-x
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2018 | Konferenz - Vortrag | ELSA-ID: 2955
Pörtner, R., Möller, J., Frahm, B., & Hass, V. C. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. Presented at the Bioprocessing Summit Europe: Practical Solutions for Today’s Bioprocess Challenges, Lisbon, Portugal.
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