Björn Frahm

Fachbereich 4 Life Science Technologies
bjoern.frahm@th-owl.de
ID
45666

168 Publikationen

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[168]
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne, T., B. Schwarze, J. Moschinski, A. Kuttig, M. Kramer, and Björn Frahm. Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags, 2013.
ELSA
 
[167]
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, Tanja, R. Pörtner, and Björn Frahm. Seed Train Optimization for Suspension Cell Culture, 2013.
ELSA
 
[166]
2013 | Sammelwerk - Beitrag | ELSA-ID: 10214
Frahm, Björn. “Seed Train Optimization for Cell Culture.” In Animal Cell Biotechnology - Methods and Protocols, edited by Ralf Pörtner, 3rd ed., 1104:355–67. Methods in Molecular Biology. Totowa, NJ: Humana Press, 2013. https://doi.org/10.1007/978-1-62703-733-4_22.
ELSA | DOI
 
[165]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 | OA
Frahm, Björn, and H. Brod. Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. Vol. 5. ESACT Proceedings. Dordrecht: Springer, 2012. https://doi.org/10.1007/978-94-007-0884-6_56.
ELSA | DOI | Download (ext.)
 
[164]
2012 | Patent | ELSA-ID: 2877
Brod, Helmut, and Björn Frahm. “Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen,” 2012.
ELSA
 
[163]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod, and R. Ludwig. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. Achema 2012. Vogel Business Media, 2012.
ELSA
 
[162]
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui, R., R. Pörtner, and Björn Frahm. Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.
ELSA
 
[161]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke, Wouter, Dietmar Haltrich, Björn Frahm, Helmut Brod, Jo Dewulf, Herman Van Langenhove, and Roland Ludwig. “A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor.” Journal of Molecular Catalysis B: Enzymatic 68, no. 2 (2011): 154–61. https://doi.org/10.1016/j.molcatb.2010.10.004.
ELSA | DOI | Download (ext.)
 
[160]
2011 | Patent | ELSA-ID: 2876
Brod, Helmut, Björn Frahm, Marc Jenne, Jörg Kauling, Franz Schmitt, and Juri Seletzky. “Flüssigkeitsbegaser,” 2011.
ELSA
 
[159]
2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod, and R. Ludwig. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, 2011.
ELSA
 
[158]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, and R. Zecirovic. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering, 2010.
ELSA
 
[157]
2010 | Patent | ELSA-ID: 2873
Brod, Helmut, Björn Frahm, and Jörg Kauling. “Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen,” 2010.
ELSA
 
[156]
2010 | Patent | ELSA-ID: 2874
Brod, Helmut, Björn Frahm, Marc Jenne, and Jörg Kauling. “Bioreaktor,” 2010.
ELSA
 
[155]
2010 | Patent | ELSA-ID: 2875
Frahm, Björn, Jörg Kauling, Andre Pütz, and Markus Schindler. “Begasungssystem,” 2010.
ELSA
 
[154]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm, Björn, and Helmut Brod. Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration, 2010.
ELSA
 
[153]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, and R. Zecirovic. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, 2010.
ELSA
 
[152]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 | OA
Frahm, Björn, Helmut Brod, and Uwe Langer. “Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration.” Cytotechnology 59, no. 1 (2009): 17–30. https://doi.org/10.1007/s10616-009-9189-9.
ELSA | DOI | Download (ext.)
 
[151]
2009 | Patent | ELSA-ID: 2872
Braun, Arndt, Helmut Brod, Björn Frahm, Marc Jenne, Jörg Kauling, and Stephan Kirchner. “Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen,” 2009.
ELSA
 
[150]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm, Björn, H. Brod, and U. Langer. Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[149]
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm, Björn, H. Brod, and U. Langer. Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[148]
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke, W., H. Van Langenhovve, Björn Frahm, H. Brod, J. Dewulf, D. Haltrich, and R. Ludwig. Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor, 2009.
ELSA
 
[147]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod, H., J. Kauling, Björn Frahm, M. Jenne, U. Langer, and B. Bödeker. Pushing the Limits in High-Density Mammalian Cell Fermentation, 2008.
ELSA
 
[146]
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm, Björn, H. Brod, M. Burnett, U. Langer, and B. Bödeker. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[145]
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm, Björn, and Helmut Brod. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[144]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm, Björn, S. Kirchner, J. Kauling, H. Brod, U. Langer, and B. Bödeker. “Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien.” Chemie Ingenieur Technik 79, no. 7 (2007): 1052–58. https://doi.org/10.1002/cite.200700070.
ELSA | DOI | Download (ext.)
 
[143]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Pörtner, Ralf, Björn Frahm, Paul Lane, Axel Munack, Kathrin Kühn, and Volker C. Hass. Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller. Cell Technology for Cell Products. Vol. 3. ESACT Proceedings. Dordrecht: Springer, 2007. https://doi.org/10.1007/978-1-4020-5476-1_84.
ELSA | DOI
 
[142]
2007 | Patent | ELSA-ID: 2870 | OA
Brod, Helmut, Björn Frahm, Jörg Kauling, and Reinhold Rose. “Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component,” 2007.
ELSA | Download (ext.)
 
[141]
2007 | Patent | ELSA-ID: 2871
Brod, Helmut, Björn Frahm, Jörg Kauling, Martin Poggel, Reinhold Rose, and Sebastian Schmidt. “Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen,” 2007.
ELSA
 
[140]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod, Helmut, Björn Frahm, and Jörg Kauling. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[139]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod, Helmut, Björn Frahm, and Jörg Kauling. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[138]
2007 | Konferenz - Poster | ELSA-ID: 2967
Frahm, Björn, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, and B. Bödeker. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2007.
ELSA
 
[137]
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 | OA
Frahm, Björn, Paul Lane, Axel Munack, and Ralf Pörtner. “Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode.” Chemie Ingenieur Technik 77, no. 4 (2005): 429–35. https://doi.org/10.1002/cite.200407094.
ELSA | DOI | Download (ext.)
 
[136]
2005 | Konferenzband - Beitrag | ELSA-ID: 2813
Frahm, Björn, and R. Pörtner. Flexible Fed-Batch Process Control of Animal Cells. Animal Cell Technology Meets Genomics. Vol. 2. ESACT Proceedings. Dordrecht: Springer, 2005. https://doi.org/10.1007/1-4020-3103-3_142.
ELSA | DOI
 
[135]
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Pörtner, Ralf, Björn Frahm, P. Lane, and A. Munack. Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive OLFO-Controller, 2005.
ELSA
 
[134]
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Pörtner, R., Björn Frahm, V. C. Hass, P. Lane, and A. Munack. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode, 2005.
ELSA
 
[133]
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 | OA
Pörtner, Ralf, Jan-Oliver Schwabe, and Björn Frahm. “Evaluation of Selected Control Strategies for Fed-Batch Cultures of a Hybridoma Cell Line.” Biotechnology and Applied Biochemistry 40 (2004). https://doi.org/10.1042/ba20030168.
ELSA | DOI | Download (ext.)
 
[132]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 | OA
Frahm, Björn, V. C. Hass, P. Lane, A. Munack, H. Märkl, and R. Pörtner. “Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung.” Chemie Ingenieur Technik 75, no. 4 (2003): 457–60. https://doi.org/10.1002/cite.200390093.
ELSA | DOI | Download (ext.)
 
[131]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 | OA
Frahm, Björn, P. Lane, H. Märkl, and R. Pörtner. “Improvement of a Mammalian Cell Culture Process by Adaptive, Model-Based Dialysis Fed-Batch Cultivation and Suppression of Apoptosis.” Bioprocess and Biosystems Engineering 26, no. 1 (2003): 1–10. https://doi.org/10.1007/s00449-003-0335-z.
ELSA | DOI | Download (ext.)
 
[130]
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Frahm, Björn, and Ralf Pörtner. Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies, 2003.
ELSA
 
[129]
2003 | Dissertation | ELSA-ID: 2393
Frahm, Björn. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH, 2003.
ELSA
 
[128]
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Frahm, Björn, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V. C. Hass, and R. Pörtner. Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control. Edited by Dieter Beckmann and Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld). Technische Systeme Für Biotechnologie Und Umwelt. Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik , 2003.
ELSA
 
[127]
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Kühn, K., Björn Frahm, R. Pörtner, P. Lane, A. Munack, and V. C. Hass. Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. Edited by European Federation of Chemical Engineering. ECCE - 4th European Congress of Chemical Engineering. Vol. 10. Granada: ECCE4, 2003.
ELSA
 
[126]
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Frahm, Björn, and Ralf Pörtner. Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung, 2003.
ELSA
 
[125]
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Hass, V. C. , K. Kühn, Björn Frahm, R. Pörtner, P. Lane, and A. Munack. Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung, 2003.
ELSA
 
[124]
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Frahm, Björn, P. Lane, A. Munack, V. C. Hass, and Ralf Pörtner. Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies, 2003.
ELSA | Dateien verfügbar
 
[123]
2003 | Konferenz - Vortrag | ELSA-ID: 2906
Pörtner, Ralf, Björn Frahm, P. Lane, V. C. Hass, A. Munack, and H. Märkl. Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung, 2003.
ELSA
 
[122]
2003 | Konferenz - Poster | ELSA-ID: 2964
Frahm, Björn, and Ralf Pörtner. CO2-off-Gas Measurement for Animal Cell Culture Processes, 2003.
ELSA
 
[121]
2003 | Konferenz - Poster | ELSA-ID: 2965
Frahm, Björn, and Ralf Pörtner. Flexible Fed-Batch Process Control of Animal Cells, 2003.
ELSA
 
[120]
2003 | Konferenz - Poster | ELSA-ID: 2966
Kühn, K., Björn Frahm, Ralf Pörtner, P. Lane, A. Munack, and V. C. Hass. Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, 2003.
ELSA
 
[119]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 | OA
Frahm, Björn, H.-C. Blank, P. Cornand, W. Oelßner, U. Guth, P. Lane, A. Munack, K. Johannsen, and R. Pörtner. “Determination of Dissolved CO2 Concentration and CO2 Production Rate of Mammalian Cell Suspension Culture Based on Off-Gas Measurement.” Journal of Biotechnology 99, no. 2 (2002): 133–48. https://doi.org/10.1016/S0168-1656(02)00180-3.
ELSA | DOI | Download (ext.)
 
[118]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 | OA
Frahm, Björn, P. Lane, H. Atzert, A. Munack, M. Hoffmann, V. C. Hass, and R. Pörtner. “Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells.” Biotechnology Progress 18, no. 5 (2002): 1095–1103. https://doi.org/10.1021/bp020035y.
ELSA | DOI | Download (ext.)
 
[117]
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Frahm, Björn, and R. Pörtner. “Reaktor-Abgasmessungen bei Zellkulturen.” BIOforum 4 (2002): 179–80.
ELSA
 
[116]
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Frahm, Björn, and Ralf Pörtner. Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen. Edited by Heiner Kaden and Forum Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung Biotechnologischer Prozesse (2001 : Waldheim). Biosystemtechnik: Innovative Biosystemtechnik - Sensorik, Aktorik Und Auswertung Biotechnologischer Prozesse. Meinsberg : Kurt-Schwabe-Inst. , 2002.
ELSA
 
[115]
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Frahm, Björn, and Ralf Pörtner. Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen, 2002.
ELSA
 
[114]
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Frahm, Björn, and Ralf Pörtner. Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells, 2002.
ELSA
 
[113]
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Frahm, Björn, and Ralf Pörtner. Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells, 2002.
ELSA
 
[112]
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Frahm, Björn, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V. C. Hass, and R. Pörtner. Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control, 2002.
ELSA
 
[111]
2001 | Konferenz - Vortrag | ELSA-ID: 7933
Frahm, Björn, and Ralf Pörtner. Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen, 2001.
ELSA
 
[110]
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
Frahm, Björn, H. Atzert, P. Lane, M. Hoffmann, V. C. Hass, A. Munack, and Ralf Pörtner. Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells. Animal Cell Technology: From Target to Market. Vol. 1. ESACT Proceedings. Dordrecht: Springer, 2001. https://doi.org/10.1007/978-94-010-0369-8_107.
ELSA | DOI
 
[109]
2001 | Konferenz - Poster | ELSA-ID: 2429
Hass, V. C., P. Lane, M. Hoffmann, Björn Frahm, J.-O. Schwabe, R. Pörtner, and A. Munack. Model-Based Control of Hybridoma Cell Cultures, 2001.
ELSA
 
[108]
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Hoffmann, M., V. C. Hass, Björn Frahm, J.-O. Schwabe, R. Pörtner, P. Lane, and A. Munack. Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen, 2001.
ELSA
 
[107]
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Frahm, Björn, and R. Pörtner. Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik, 2001.
ELSA
 
[106]
2001 | Konferenz - Poster | ELSA-ID: 2960
Frahm, Björn, H. Atzert, J.-O. Schwabe, P. Lane, A. Munack, M. Hoffmann, V. C. Hass, and R. Pörtner. Adaptive Modellgestützte Steuerung von Zellkulturprozessen, 2001.
ELSA
 
[105]
2001 | Konferenz - Poster | ELSA-ID: 2961
Lane, P., Björn Frahm, H. Atzert, J.-O. Schwabe, M. Hoffmann, V. C. Hass, and R. Pörtner. Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities, 2001.
ELSA
 
[104]
2001 | Konferenz - Poster | ELSA-ID: 2962
Frahm, Björn, H. Atzert, P. Lane, M. Hoffmann, V. C. Hass, A. Munack, and R. Pörtner. Development of an Automated, Model-Based, Adaptive Control for the Effective Cultivation of Hybridoma Cells, 2001.
ELSA
 
[103]
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 | OA
Hass, V.C., P. Lane, M. Hoffmann, Björn Frahm, J.-O. Schwabe, R. Pörtner, and A. Munack. Model-Based Control of Hybridoma Cell Cultures. Edited by Published for the International Federation of Automatic Control by Pergamon . Computer Applications in Biotechnology, 2001: Modelling, Monitoring and Control of Biotechnological Processes. Vol. 34.   IFAC Proceedings Volumes / IFAC, International Federation of Automatic Control. Oxford: ScienceDirect, 2001. https://doi.org/10.1016/S1474-6670(17)34240-4.
ELSA | DOI | Download (ext.)
 
[102]
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Anderelei, T., Björn Frahm, and J. Büchs. Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren, 2000.
ELSA
 
[101]
2000 | Konferenz - Poster | ELSA-ID: 2959
Hoffmann, M., Björn Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V. C. Hass, and A. Munack. Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus, 2000.
ELSA
 
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168 Publikationen

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[168]
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne, T., B. Schwarze, J. Moschinski, A. Kuttig, M. Kramer, and Björn Frahm. Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags, 2013.
ELSA
 
[167]
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, Tanja, R. Pörtner, and Björn Frahm. Seed Train Optimization for Suspension Cell Culture, 2013.
ELSA
 
[166]
2013 | Sammelwerk - Beitrag | ELSA-ID: 10214
Frahm, Björn. “Seed Train Optimization for Cell Culture.” In Animal Cell Biotechnology - Methods and Protocols, edited by Ralf Pörtner, 3rd ed., 1104:355–67. Methods in Molecular Biology. Totowa, NJ: Humana Press, 2013. https://doi.org/10.1007/978-1-62703-733-4_22.
ELSA | DOI
 
[165]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 | OA
Frahm, Björn, and H. Brod. Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. Vol. 5. ESACT Proceedings. Dordrecht: Springer, 2012. https://doi.org/10.1007/978-94-007-0884-6_56.
ELSA | DOI | Download (ext.)
 
[164]
2012 | Patent | ELSA-ID: 2877
Brod, Helmut, and Björn Frahm. “Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen,” 2012.
ELSA
 
[163]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod, and R. Ludwig. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. Achema 2012. Vogel Business Media, 2012.
ELSA
 
[162]
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui, R., R. Pörtner, and Björn Frahm. Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.
ELSA
 
[161]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke, Wouter, Dietmar Haltrich, Björn Frahm, Helmut Brod, Jo Dewulf, Herman Van Langenhove, and Roland Ludwig. “A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor.” Journal of Molecular Catalysis B: Enzymatic 68, no. 2 (2011): 154–61. https://doi.org/10.1016/j.molcatb.2010.10.004.
ELSA | DOI | Download (ext.)
 
[160]
2011 | Patent | ELSA-ID: 2876
Brod, Helmut, Björn Frahm, Marc Jenne, Jörg Kauling, Franz Schmitt, and Juri Seletzky. “Flüssigkeitsbegaser,” 2011.
ELSA
 
[159]
2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke, W., D. Haltrich, Björn Frahm, H. Brod, and R. Ludwig. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, 2011.
ELSA
 
[158]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, and R. Zecirovic. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. Proceedings 19th International Congress of Chemical and Process Engineering. Czech Society of Chemical Engineering, 2010.
ELSA
 
[157]
2010 | Patent | ELSA-ID: 2873
Brod, Helmut, Björn Frahm, and Jörg Kauling. “Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen,” 2010.
ELSA
 
[156]
2010 | Patent | ELSA-ID: 2874
Brod, Helmut, Björn Frahm, Marc Jenne, and Jörg Kauling. “Bioreaktor,” 2010.
ELSA
 
[155]
2010 | Patent | ELSA-ID: 2875
Frahm, Björn, Jörg Kauling, Andre Pütz, and Markus Schindler. “Begasungssystem,” 2010.
ELSA
 
[154]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm, Björn, and Helmut Brod. Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration, 2010.
ELSA
 
[153]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks, B., Björn Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, and R. Zecirovic. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, 2010.
ELSA
 
[152]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 | OA
Frahm, Björn, Helmut Brod, and Uwe Langer. “Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration.” Cytotechnology 59, no. 1 (2009): 17–30. https://doi.org/10.1007/s10616-009-9189-9.
ELSA | DOI | Download (ext.)
 
[151]
2009 | Patent | ELSA-ID: 2872
Braun, Arndt, Helmut Brod, Björn Frahm, Marc Jenne, Jörg Kauling, and Stephan Kirchner. “Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen,” 2009.
ELSA
 
[150]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm, Björn, H. Brod, and U. Langer. Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[149]
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm, Björn, H. Brod, and U. Langer. Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[148]
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke, W., H. Van Langenhovve, Björn Frahm, H. Brod, J. Dewulf, D. Haltrich, and R. Ludwig. Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor, 2009.
ELSA
 
[147]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod, H., J. Kauling, Björn Frahm, M. Jenne, U. Langer, and B. Bödeker. Pushing the Limits in High-Density Mammalian Cell Fermentation, 2008.
ELSA
 
[146]
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm, Björn, H. Brod, M. Burnett, U. Langer, and B. Bödeker. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[145]
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm, Björn, and Helmut Brod. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[144]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm, Björn, S. Kirchner, J. Kauling, H. Brod, U. Langer, and B. Bödeker. “Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien.” Chemie Ingenieur Technik 79, no. 7 (2007): 1052–58. https://doi.org/10.1002/cite.200700070.
ELSA | DOI | Download (ext.)
 
[143]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Pörtner, Ralf, Björn Frahm, Paul Lane, Axel Munack, Kathrin Kühn, and Volker C. Hass. Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller. Cell Technology for Cell Products. Vol. 3. ESACT Proceedings. Dordrecht: Springer, 2007. https://doi.org/10.1007/978-1-4020-5476-1_84.
ELSA | DOI
 
[142]
2007 | Patent | ELSA-ID: 2870 | OA
Brod, Helmut, Björn Frahm, Jörg Kauling, and Reinhold Rose. “Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component,” 2007.
ELSA | Download (ext.)
 
[141]
2007 | Patent | ELSA-ID: 2871
Brod, Helmut, Björn Frahm, Jörg Kauling, Martin Poggel, Reinhold Rose, and Sebastian Schmidt. “Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen,” 2007.
ELSA
 
[140]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod, Helmut, Björn Frahm, and Jörg Kauling. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[139]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod, Helmut, Björn Frahm, and Jörg Kauling. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[138]
2007 | Konferenz - Poster | ELSA-ID: 2967
Frahm, Björn, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, and B. Bödeker. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2007.
ELSA
 
[137]
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 | OA
Frahm, Björn, Paul Lane, Axel Munack, and Ralf Pörtner. “Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode.” Chemie Ingenieur Technik 77, no. 4 (2005): 429–35. https://doi.org/10.1002/cite.200407094.
ELSA | DOI | Download (ext.)
 
[136]
2005 | Konferenzband - Beitrag | ELSA-ID: 2813
Frahm, Björn, and R. Pörtner. Flexible Fed-Batch Process Control of Animal Cells. Animal Cell Technology Meets Genomics. Vol. 2. ESACT Proceedings. Dordrecht: Springer, 2005. https://doi.org/10.1007/1-4020-3103-3_142.
ELSA | DOI
 
[135]
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Pörtner, Ralf, Björn Frahm, P. Lane, and A. Munack. Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive OLFO-Controller, 2005.
ELSA
 
[134]
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Pörtner, R., Björn Frahm, V. C. Hass, P. Lane, and A. Munack. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode, 2005.
ELSA
 
[133]
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 | OA
Pörtner, Ralf, Jan-Oliver Schwabe, and Björn Frahm. “Evaluation of Selected Control Strategies for Fed-Batch Cultures of a Hybridoma Cell Line.” Biotechnology and Applied Biochemistry 40 (2004). https://doi.org/10.1042/ba20030168.
ELSA | DOI | Download (ext.)
 
[132]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 | OA
Frahm, Björn, V. C. Hass, P. Lane, A. Munack, H. Märkl, and R. Pörtner. “Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung.” Chemie Ingenieur Technik 75, no. 4 (2003): 457–60. https://doi.org/10.1002/cite.200390093.
ELSA | DOI | Download (ext.)
 
[131]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 | OA
Frahm, Björn, P. Lane, H. Märkl, and R. Pörtner. “Improvement of a Mammalian Cell Culture Process by Adaptive, Model-Based Dialysis Fed-Batch Cultivation and Suppression of Apoptosis.” Bioprocess and Biosystems Engineering 26, no. 1 (2003): 1–10. https://doi.org/10.1007/s00449-003-0335-z.
ELSA | DOI | Download (ext.)
 
[130]
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Frahm, Björn, and Ralf Pörtner. Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies, 2003.
ELSA
 
[129]
2003 | Dissertation | ELSA-ID: 2393
Frahm, Björn. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH, 2003.
ELSA
 
[128]
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Frahm, Björn, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V. C. Hass, and R. Pörtner. Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control. Edited by Dieter Beckmann and Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld). Technische Systeme Für Biotechnologie Und Umwelt. Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik , 2003.
ELSA
 
[127]
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Kühn, K., Björn Frahm, R. Pörtner, P. Lane, A. Munack, and V. C. Hass. Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. Edited by European Federation of Chemical Engineering. ECCE - 4th European Congress of Chemical Engineering. Vol. 10. Granada: ECCE4, 2003.
ELSA
 
[126]
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Frahm, Björn, and Ralf Pörtner. Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung, 2003.
ELSA
 
[125]
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Hass, V. C. , K. Kühn, Björn Frahm, R. Pörtner, P. Lane, and A. Munack. Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung, 2003.
ELSA
 
[124]
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Frahm, Björn, P. Lane, A. Munack, V. C. Hass, and Ralf Pörtner. Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies, 2003.
ELSA | Dateien verfügbar
 
[123]
2003 | Konferenz - Vortrag | ELSA-ID: 2906
Pörtner, Ralf, Björn Frahm, P. Lane, V. C. Hass, A. Munack, and H. Märkl. Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung, 2003.
ELSA
 
[122]
2003 | Konferenz - Poster | ELSA-ID: 2964
Frahm, Björn, and Ralf Pörtner. CO2-off-Gas Measurement for Animal Cell Culture Processes, 2003.
ELSA
 
[121]
2003 | Konferenz - Poster | ELSA-ID: 2965
Frahm, Björn, and Ralf Pörtner. Flexible Fed-Batch Process Control of Animal Cells, 2003.
ELSA
 
[120]
2003 | Konferenz - Poster | ELSA-ID: 2966
Kühn, K., Björn Frahm, Ralf Pörtner, P. Lane, A. Munack, and V. C. Hass. Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, 2003.
ELSA
 
[119]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 | OA
Frahm, Björn, H.-C. Blank, P. Cornand, W. Oelßner, U. Guth, P. Lane, A. Munack, K. Johannsen, and R. Pörtner. “Determination of Dissolved CO2 Concentration and CO2 Production Rate of Mammalian Cell Suspension Culture Based on Off-Gas Measurement.” Journal of Biotechnology 99, no. 2 (2002): 133–48. https://doi.org/10.1016/S0168-1656(02)00180-3.
ELSA | DOI | Download (ext.)
 
[118]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 | OA
Frahm, Björn, P. Lane, H. Atzert, A. Munack, M. Hoffmann, V. C. Hass, and R. Pörtner. “Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells.” Biotechnology Progress 18, no. 5 (2002): 1095–1103. https://doi.org/10.1021/bp020035y.
ELSA | DOI | Download (ext.)
 
[117]
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Frahm, Björn, and R. Pörtner. “Reaktor-Abgasmessungen bei Zellkulturen.” BIOforum 4 (2002): 179–80.
ELSA
 
[116]
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Frahm, Björn, and Ralf Pörtner. Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen. Edited by Heiner Kaden and Forum Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung Biotechnologischer Prozesse (2001 : Waldheim). Biosystemtechnik: Innovative Biosystemtechnik - Sensorik, Aktorik Und Auswertung Biotechnologischer Prozesse. Meinsberg : Kurt-Schwabe-Inst. , 2002.
ELSA
 
[115]
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Frahm, Björn, and Ralf Pörtner. Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen, 2002.
ELSA
 
[114]
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Frahm, Björn, and Ralf Pörtner. Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells, 2002.
ELSA
 
[113]
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Frahm, Björn, and Ralf Pörtner. Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells, 2002.
ELSA
 
[112]
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Frahm, Björn, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V. C. Hass, and R. Pörtner. Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control, 2002.
ELSA
 
[111]
2001 | Konferenz - Vortrag | ELSA-ID: 7933
Frahm, Björn, and Ralf Pörtner. Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen, 2001.
ELSA
 
[110]
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
Frahm, Björn, H. Atzert, P. Lane, M. Hoffmann, V. C. Hass, A. Munack, and Ralf Pörtner. Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells. Animal Cell Technology: From Target to Market. Vol. 1. ESACT Proceedings. Dordrecht: Springer, 2001. https://doi.org/10.1007/978-94-010-0369-8_107.
ELSA | DOI
 
[109]
2001 | Konferenz - Poster | ELSA-ID: 2429
Hass, V. C., P. Lane, M. Hoffmann, Björn Frahm, J.-O. Schwabe, R. Pörtner, and A. Munack. Model-Based Control of Hybridoma Cell Cultures, 2001.
ELSA
 
[108]
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Hoffmann, M., V. C. Hass, Björn Frahm, J.-O. Schwabe, R. Pörtner, P. Lane, and A. Munack. Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen, 2001.
ELSA
 
[107]
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Frahm, Björn, and R. Pörtner. Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik, 2001.
ELSA
 
[106]
2001 | Konferenz - Poster | ELSA-ID: 2960
Frahm, Björn, H. Atzert, J.-O. Schwabe, P. Lane, A. Munack, M. Hoffmann, V. C. Hass, and R. Pörtner. Adaptive Modellgestützte Steuerung von Zellkulturprozessen, 2001.
ELSA
 
[105]
2001 | Konferenz - Poster | ELSA-ID: 2961
Lane, P., Björn Frahm, H. Atzert, J.-O. Schwabe, M. Hoffmann, V. C. Hass, and R. Pörtner. Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities, 2001.
ELSA
 
[104]
2001 | Konferenz - Poster | ELSA-ID: 2962
Frahm, Björn, H. Atzert, P. Lane, M. Hoffmann, V. C. Hass, A. Munack, and R. Pörtner. Development of an Automated, Model-Based, Adaptive Control for the Effective Cultivation of Hybridoma Cells, 2001.
ELSA
 
[103]
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 | OA
Hass, V.C., P. Lane, M. Hoffmann, Björn Frahm, J.-O. Schwabe, R. Pörtner, and A. Munack. Model-Based Control of Hybridoma Cell Cultures. Edited by Published for the International Federation of Automatic Control by Pergamon . Computer Applications in Biotechnology, 2001: Modelling, Monitoring and Control of Biotechnological Processes. Vol. 34.   IFAC Proceedings Volumes / IFAC, International Federation of Automatic Control. Oxford: ScienceDirect, 2001. https://doi.org/10.1016/S1474-6670(17)34240-4.
ELSA | DOI | Download (ext.)
 
[102]
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Anderelei, T., Björn Frahm, and J. Büchs. Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren, 2000.
ELSA
 
[101]
2000 | Konferenz - Poster | ELSA-ID: 2959
Hoffmann, M., Björn Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V. C. Hass, and A. Munack. Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus, 2000.
ELSA
 
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