Björn Frahm

Fachbereich 4 Life Science Technologies
bjoern.frahm@th-owl.de
ID
45666

138 Publikationen

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[138]
2023 | Konferenz - Poster | ELSA-ID: 9574
Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression. BioProcessingDays 2023, Recklinghausen.
ELSA
 
[137]
2022 | Konferenz - Vortrag | ELSA-ID: 7932
Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (2022). A systematic, model-based workflow for risk-based decision making in upstream development. Presented at the 5th annual Bioprocessing Summit Europe, Barcelona, Spain.
ELSA
 
[136]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7975
Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. Processes, Special Issue: “Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing,” 10(883). https://doi.org/10.3390/pr10050883
ELSA | DOI
 
[135]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier, V., Deppe, S., Hernández Rodriguez, T., Kuhfuß, F., Moser, A., Hass, V. C., … Frahm, B. (2022). Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology, 4, 102–119. https://doi.org/10.1016/j.crbiot.2022.01.005
ELSA | DOI
 
[134]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez, T., & Frahm, B. (2021). Digital Seed Train Twins and Statistical Methods. In Advances in Biochemical Engineering/Biotechnology (p. 35). Berlin, Heidelberg: Springer. https://doi.org/10.1007/978-3-030-71660-8
ELSA | DOI
 
[133]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez, T., & Frahm, B. (2021). Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. Presented at the International Week “Digitalization and Sustainability in Higher Education,” SeAMK, Seinäjoki, Finnland.
ELSA
 
[132]
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser, A., Möller, J., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., … Hass, V. C. (2021). Model-assisted Design of Experiments - Concept, Software and Applications. Presented at the 24th International Congress of Chemical and Process Engineering, CHISA 2021, as a web conference, Prague, Czech Republic.
ELSA
 
[131]
2021 | Lexikoneintrag | ELSA-ID: 7939
Wirtanen, G., Alarinta, J., Frahm, B., & Fasse, S. (2021). Bovine Colostrum for Human Consumption. In MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science.
ELSA
 
[130]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
Fasse, S., Alarinta, J., Frahm, B., & Wirtanen, G. (2021). Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy, 2(4), 556–575. https://doi.org/10.3390/dairy2040044
ELSA | DOI
 
[129]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7983
Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm, B. (2021). Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. Processes, Special Issue: “Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing,” 9(964). https://doi.org/10.3390/pr9060964
ELSA | DOI
 
[128]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2021). Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering, 44(4), 793–808. https://doi.org/10.1007/s00449-020-02488-1
ELSA | DOI
 
[127]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser, A., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Frahm, B., Pörtner, R., … Möller, J. (2021). Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering, 44(4), 683–700. https://doi.org/10.1007/s00449-020-02478-3
ELSA | DOI
 
[126]
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Blome, A., Luttmann, M., Frahm, B., & Müller, U. (2021). Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. Presented at the Seminar Life Science Technologies, TH OWL, Lemgo, Germany.
ELSA
 
[125]
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
Möller, J., Hernández Rodríguez, T., Müller, J., Arndt, L., Kuchemüller, K. B., Frahm, B., … Pörtner, R. (2020). Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes. Computers & Chemical Engineering, 134, 1–13. https://doi.org/10.1016/j.compchemeng.2019.106693
ELSA | DOI
 
[124]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Hernández Rodríguez, T., & Frahm, B. (2020). Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols (Vol. 2095, pp. 251–267). Berlin, Heidelberg, New York: Springer. https://doi.org/10.1007/978-1-0716-0191-4_14
ELSA | DOI
 
[123]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
Deppe, S., Frahm, B., Hass, V. C., Hernández Rodríguez, T., Kuchemüller, K. B., Möller, J., & Pörtner, R. (2020). Estimation of Process Model Parameters. In R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols (Vol. 2095, pp. 213–234). Berlin ; Heidelberg ; New York: Springer. https://doi.org/10.1007/978-1-0716-0191-4_12
ELSA | DOI
 
[122]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, Claus , Pörtner, R., & Frahm, B. (2020). Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BMC Proceedings (Vol. 14, p. P408). Copenhagen, Denmark.: BioMed Central. https://doi.org/10.1186/s12919-020-00188-y
ELSA | Dateien verfügbar | DOI
 
[121]
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Deppe, S., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[120]
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe, S., Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Ifrim, G. A., … Frahm, B. (2020). Model-assisted Design of Experiments for algae cultivation. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[119]
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2020). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[118]
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[117]
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[116]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez, T., Frahm, B., & Posch, C. (2020). Integration of prior knowledge and digital tools for uncertainty-based decision support. Presented at the 1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable, Sandoz, Austria.
ELSA
 
[115]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1225 – 1226). Wiley. https://doi.org/10.1002/cite.202055235
ELSA | DOI
 
[114]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1241 – 1242). Wiley. https://doi.org/10.1002/cite.202055234
ELSA | DOI
 
[113]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, C., Pörtner, R., & Frahm, B. (2019). Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering, 116(11), 2944–2959. https://doi.org/10.1002/bit.27125
ELSA | DOI | Download (ext.)
 
[112]
2019 | Konferenzband - Beitrag | ELSA-ID: 2400
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Multivariable control strategy for the photosynthetic cultures of microalgae. 2019 23rd International Conference on System Theory, Control and Computing (ICSTCC). IEEE. https://doi.org/10.1109/icstcc.2019.8886109
ELSA | DOI
 
[111]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller, J., Müller, J., Hernández Rodriguez, T., Kuchemüller, K. B., Arndt, L., Frahm, B., … Pörtner, R. (2019). Workflow for model-assisted design and scale-up of biopharmaceutical production processes. Presented at the BioTech 2019 - Biopharmaceutical Manufacturing and Single-Use Technologies: Process intensification and continuous bioprocessing with single-use devices, Wädenswil, Switzerland.
ELSA
 
[110]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller, J., Kuchemüller, K. B., Moser, A., Hass, V. C., Hernández Rodriguez, T., Deppe, S., … Pörtner, R. (2019). Model-Assisted Design of Experiments. Presented at the 5th European Congress of Applied Biotechnology, Florence, Italy.
ELSA
 
[109]
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Novel control strategy for microalgae in photobioreactor. Presented at the 23rd International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania.
ELSA
 
[108]
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the BioProcessingDays 2019, Recklinghausen, Germany.
ELSA
 
[107]
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the 26th Meeting of the European Society for Animal Cell Technology (ESACT): Cell culture technologies: bridging academia and industry to provide solutions for patients, Copenhagen, Denmark.
ELSA
 
[106]
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Deppe, S., Ifrim, G. A., Moser, A., … Pörtner, R. (2019). Model-Assisted Design of Experiments – Software Toolbox. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[105]
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., Tölle, M., Kuhfuß, F., Möller, J., … Frahm, B. (2019). Model-assisted Design of Experiments for algae cultivation. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[104]
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2019). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[103]
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[102]
2019 | Konferenz - Poster | ELSA-ID: 3006
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Multivariable control strategy for the photosynthetic cultures of microalgae. Presented at the 23rd International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania.
ELSA
 
[101]
2019 | Konferenz - Vortrag | ELSA-ID: 7928
Frahm, B. (2019). Scale-up of stirred vessels. Presented at the International Week “Welfare and Responsibility,” SeAMK, Seinäjoki, Finnland.
ELSA
 
[100]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Frahm, B., Hass, V. C., & Pörtner, R. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review, 3, 39–41.
ELSA | Download (ext.)
 
[99]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2018). Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. BMC Proceedings (Vol. 112, p. P175). Lausanne, Switzerland: BioMed Central. https://doi.org/10.1186/s12919-018-0097-x
ELSA | Dateien verfügbar | DOI
 
[98]
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Pörtner, R., Möller, J., Frahm, B., & Hass, V. C. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. Presented at the Bioprocessing Summit Europe: Practical Solutions for Today’s Bioprocess Challenges, Lisbon, Portugal.
ELSA
 
[97]
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hernández Rodriguez, T., Frahm, B., … Pörtner, R. (2018). Model-Assisted Design and Optimization of Process Strategies. Presented at the BioProcessingDays 2018, Recklinghausen, Germany.
ELSA
 
[96]
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez, T., Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hass, V. C., … Pörtner, R. (2018). Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. Presented at the 5th BioProScale Symposium: Innovative scale up and scale down for bioprocess intensification, Berlin, Germany.
ELSA
 
[95]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez, T., Frahm, B., Posch, C., Schmutzhard, J., & Stettner, J. (2018). A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. Presented at the Sandoz, Kundl, Austria.
ELSA
 
[94]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez, T., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the 3. Lippischer Automatisierungstreff der Produktions- und Werkstofftechnik (LAT/PWT), Lemgo, Germany.
ELSA
 
[93]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner, R., Möller, J., Hernández Rodriguez, T., Frahm, B., & Hass, V. C. (2017). Model-assisted design and optimization of biotechnological processes. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
ELSA
 
[92]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez, T., Koopmann, K. S., Klaes, J., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the MATLAB EXPO, Track “Optimierungsaufgaben in der Praxis,” Munic, Germany.
ELSA
 
[91]
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez, T., Koopmann, K. S., Pörtner, R., & Frahm, B. (2017). Influence of parameter accuracies in cell culture seed train simulations. Presented at the BioProcessingDays 2017, Recklinghausen, Germany.
ELSA
 
[90]
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the 25th Meeting of the European Society for Animal Cell Technology (ESACT): Cell technologies for innovative therapies, Lausanne, Switzerland.
ELSA
 
[89]
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez, T., Krull, S., Hass, V. C., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production,” Neu-Ulm, Germany.
ELSA
 
[88]
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
Pörtner, R., Platas Barradas, O., Frahm, B., & Hass, V. C. (2016). Advanced Process and Control Strategies for Bioreactors. In Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls (pp. 463–493). Amsterdam: Elsevier. https://doi.org/10.1016/b978-0-444-63663-8.00016-1
ELSA | DOI
 
[87]
2016 | Konferenz - Poster | ELSA-ID: 2991
Beshay, U., Feldt, S., Schwarze, B., Wefing, P., Hahne, T., Moschinski, J., … Frahm, B. (2016). DMA Photobioreactor System – Cultivation at low shear stress and optional membrane aeration. Presented at the BioProcessingDays 2016, Recklinghausen, Germany.
ELSA
 
[86]
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez, T., Vörtler, S., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2016). A software tool for biopharmaceutical seed train design and optimization. Presented at the BioProcessingDays 2016, Recklinghausen, Germany.
ELSA
 
[85]
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann, K. S., Hernández Rodriguez, T., Vörtler, S., Beshay, U., Möller, J., Pörtner, R., & Frahm, B. (2016). Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. Presented at the DECHEMA Himmelfahrtstagung “New Frontiers for Biotech-Processes,” Koblenz, Germany.
ELSA
 
[84]
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Kern, S., Platas-Barradas, O., Pörtner, R., & Frahm, B. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Cytotechnology, 68(4), 1019–1032. https://doi.org/10.1007/s10616-015-9858-9
ELSA | DOI | Download (ext.)
 
[83]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. BMC proceedings / BioMed Central (Vol. 9). BioMed Central. https://doi.org/10.1186/1753-6561-9-s9-p43
ELSA | DOI | Download (ext.)
 
[82]
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 | OA
Kern, S., Platas Barradas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. BMC proceedings / BioMed Central (Vol. 9). BioMed Central. https://doi.org/10.1186/1753-6561-9-s9-p44
ELSA | DOI | Download (ext.)
 
[81]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm, B., Pörtner, R., Kern, S., & Hernández Rodriguez, T. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the ACHEMA 2015, Frankfurt am Main, Germany.
ELSA | Dateien verfügbar
 
[80]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm, B., Hernández Rodriguez, T., Kern, S., Koopmann, K. S., Beshay, U., Platas-Barradas, O., & Pörtner, R. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg, Germany.
ELSA
 
[79]
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses,” Hamburg, Germany.
ELSA
 
[78]
2015 | Konferenz - Poster | ELSA-ID: 2986
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Presented at the DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses,” Hamburg, Germany.
ELSA
 
[77]
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). A software tool for biopharmaceutical seed train design and optimization. Presented at the MATLAB EXPO, Munic, Germany.
ELSA
 
[76]
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the 24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products, Barcelona, Spain.
ELSA
 
[75]
2015 | Konferenz - Poster | ELSA-ID: 2990
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Presented at the 24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products, Barcelona, Spain.
ELSA
 
[74]
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Hahne, T., Schwarze, B., Kramer, M., & Frahm, B. (2014). Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags. Journal of Algal Biomass Utilization, 5(2), 66–73.
ELSA
 
[73]
2014 | Patent | ELSA-ID: 2878
Frahm, B., & Meier, U. (2014). Beleuchtung von disposable Bioreaktoren.
ELSA
 
[72]
2014 | Konferenz - Poster | ELSA-ID: 2984
Drews, F., Drews, G., Folz, C., Platz, G., Gassenmeier, T., Kramer, M., … Frahm, B. (2014). Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. Presented at the 7. Bundesalgenstammtisch, Köthen, Germany.
ELSA
 
[71]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. BMC proceedings / BioMed Central (Vol. 7). BioMed Central . https://doi.org/10.1186/1753-6561-7-s6-p9
ELSA | DOI | Download (ext.)
 
[70]
2013 | Konferenzband - Beitrag | ELSA-ID: 2818 | OA
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Model-based design of the first steps of a seed train for cell culture processes. BMC proceedings / BioMed Central (Vol. 7). BioMed Central. https://doi.org/10.1186/1753-6561-7-s6-p11
ELSA | DOI | Download (ext.)
 
[69]
2013 | Konferenz - Poster | ELSA-ID: 2980
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung “Effiziente Verfahren und Anlagen in der Bioverfahrenstechnik und Lebensmittelbiotechnologie,” Bad Wildungen, Germany.
ELSA
 
[68]
2013 | Konferenz - Poster | ELSA-ID: 2981
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Model-based design of the first steps of a seed train for cell culture processes. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.
ELSA
 
[67]
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne, T., Schwarze, B., Moschinski, J., Kuttig, A., Kramer, M., & Frahm, B. (2013). Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags. Presented at the 6. Bundesalgenstammtisch, Hamburg, Germany.
ELSA
 
[66]
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.
ELSA
 
[65]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 | OA
Frahm, B., & Brod, H. (2012). Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009 (Vol. 5, pp. 355–359). Dordrecht: Springer. https://doi.org/10.1007/978-94-007-0884-6_56
ELSA | DOI | Download (ext.)
 
[64]
2012 | Patent | ELSA-ID: 2877
Brod, H., & Frahm, B. (2012). Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.
ELSA
 
[63]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., & Ludwig, R. (2012). Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Achema 2012. Frankfurt am Main, Germany: Vogel Business Media.
ELSA
 
[62]
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui, R., Pörtner, R., & Frahm, B. (2012). Optimierung des Seed trains von Suspensions-Zellkulturen. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung “Biopharmazeutische Produktion,” Freiburg, Germany.
ELSA
 
[61]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., Dewulf, J., Van Langenhove, H., & Ludwig, R. (2011). A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic, 68(2), 154–161. https://doi.org/10.1016/j.molcatb.2010.10.004
ELSA | DOI | Download (ext.)
 
[60]
2011 | Patent | ELSA-ID: 2876
Brod, H., Frahm, B., Jenne, M., Kauling, J., Schmitt, F., & Seletzky, J. (2011). Flüssigkeitsbegaser.
ELSA
 
[59]
2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., & Ludwig, R. (2011). Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Presented at the 1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting, Berlin, Germany.
ELSA
 
[58]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Prague, CZ: Czech Society of Chemical Engineering.
ELSA
 
[57]
2010 | Patent | ELSA-ID: 2873
Brod, H., Frahm, B., & Kauling, J. (2010). Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.
ELSA
 
[56]
2010 | Patent | ELSA-ID: 2874
Brod, H., Frahm, B., Jenne, M., & Kauling, J. (2010). Bioreaktor.
ELSA
 
[55]
2010 | Patent | ELSA-ID: 2875
Frahm, B., Kauling, J., Pütz, A., & Schindler, M. (2010). Begasungssystem.
ELSA
 
[54]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm, B., & Brod, H. (2010). Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration. Presented at the 6th annual Optimizing Cell Culture Technology-Meeting as part of The Bioprocessing Summit - Practical Solutions for Today’s Laboratory Challenges, Boston, USA.
ELSA
 
[53]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). Intensified absorption and distillation devices for modular chemical production processes. Presented at the 19th International Congress of Chemical and Process Engineering, CHISA , Prague, Czech Republic.
ELSA
 
[52]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 | OA
Frahm, B., Brod, H., & Langer, U. (2009). Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology, 59(1), 17–30. https://doi.org/10.1007/s10616-009-9189-9
ELSA | DOI | Download (ext.)
 
[51]
2009 | Patent | ELSA-ID: 2872
Braun, A., Brod, H., Frahm, B., Jenne, M., Kauling, J., & Kirchner, S. (2009). Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.
ELSA
 
[50]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm, B., Brod, H., & Langer, U. (2009). Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). Presented at the Industrial Biotechnology Exhibition & Partnering Conference at ACHEMA , Frankfurt am Main, Germany.
ELSA
 
[49]
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm, B., Brod, H., & Langer, U. (2009). Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). Presented at the 21st Meeting of the European Society for Animal Cell Technology (ESACT): Cellular Solutions for Clinical Challenges, Dublin, Ireland.
ELSA
 
[48]
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke, W., Van Langenhovve, H., Frahm, B., Brod, H., Dewulf, J., Haltrich, D., & Ludwig, R. (2009). Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor. Presented at the COST 928 Control and exploitation of enzymes for added-value products, 3rd Annual Workshop, Krakow, Poland.
ELSA
 
[47]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod, H., Kauling, J., Frahm, B., Jenne, M., Langer, U., & Bödeker, B. (2008). Pushing the Limits in High-Density Mammalian Cell Fermentation. Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.
ELSA
 
[46]
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm, B., Brod, H., Burnett, M., Langer, U., & Bödeker, B. (2008). High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). Presented at the Bayer Science Day, Palladium, Cologne, Germany.
ELSA
 
[45]
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm, B., & Brod, H. (2008). High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.
ELSA
 
[44]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm, B., Kirchner, S., Kauling, J., Brod, H., Langer, U., & Bödeker, B. (2007). Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien. Chemie Ingenieur Technik, 79(7), 1052–1058. https://doi.org/10.1002/cite.200700070
ELSA | DOI | Download (ext.)
 
[43]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Pörtner, R., Frahm, B., Lane, P., Munack, A., Kühn, K., & Hass, V. C. (2007). Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller. Cell Technology for Cell Products (Vol. 3, pp. 497–501). Dordrecht: Springer. https://doi.org/10.1007/978-1-4020-5476-1_84
ELSA | DOI
 
[42]
2007 | Patent | ELSA-ID: 2870 | OA
Brod, H., Frahm, B., Kauling, J., & Rose, R. (2007). Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.
ELSA | Download (ext.)
 
[41]
2007 | Patent | ELSA-ID: 2871
Brod, H., Frahm, B., Kauling, J., Poggel, M., Rose, R., & Schmidt, S. (2007). Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.
ELSA
 
[40]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod, H., Frahm, B., & Kauling, J. (2007). Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. Presented at the GVC Fachausschuss Mischvorgänge, Würzburg, Germany.
ELSA
 
[39]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod, H., Frahm, B., & Kauling, J. (2007). Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung „Aufarbeitung biotechnologischer Produkte", Osnabrück, Germany.
ELSA
 
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[138]
2023 | Konferenz - Poster | ELSA-ID: 9574
Ramm, S., Hernández Rodriguez, T., Frahm, B., & Pein-Hackelbusch, M. (2023). Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression. BioProcessingDays 2023, Recklinghausen.
ELSA
 
[137]
2022 | Konferenz - Vortrag | ELSA-ID: 7932
Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (2022). A systematic, model-based workflow for risk-based decision making in upstream development. Presented at the 5th annual Bioprocessing Summit Europe, Barcelona, Spain.
ELSA
 
[136]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7975
Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. Processes, Special Issue: “Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing,” 10(883). https://doi.org/10.3390/pr10050883
ELSA | DOI
 
[135]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier, V., Deppe, S., Hernández Rodriguez, T., Kuhfuß, F., Moser, A., Hass, V. C., … Frahm, B. (2022). Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology, 4, 102–119. https://doi.org/10.1016/j.crbiot.2022.01.005
ELSA | DOI
 
[134]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez, T., & Frahm, B. (2021). Digital Seed Train Twins and Statistical Methods. In Advances in Biochemical Engineering/Biotechnology (p. 35). Berlin, Heidelberg: Springer. https://doi.org/10.1007/978-3-030-71660-8
ELSA | DOI
 
[133]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez, T., & Frahm, B. (2021). Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. Presented at the International Week “Digitalization and Sustainability in Higher Education,” SeAMK, Seinäjoki, Finnland.
ELSA
 
[132]
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser, A., Möller, J., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., … Hass, V. C. (2021). Model-assisted Design of Experiments - Concept, Software and Applications. Presented at the 24th International Congress of Chemical and Process Engineering, CHISA 2021, as a web conference, Prague, Czech Republic.
ELSA
 
[131]
2021 | Lexikoneintrag | ELSA-ID: 7939
Wirtanen, G., Alarinta, J., Frahm, B., & Fasse, S. (2021). Bovine Colostrum for Human Consumption. In MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science.
ELSA
 
[130]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
Fasse, S., Alarinta, J., Frahm, B., & Wirtanen, G. (2021). Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy, 2(4), 556–575. https://doi.org/10.3390/dairy2040044
ELSA | DOI
 
[129]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7983
Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm, B. (2021). Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. Processes, Special Issue: “Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing,” 9(964). https://doi.org/10.3390/pr9060964
ELSA | DOI
 
[128]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2021). Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering, 44(4), 793–808. https://doi.org/10.1007/s00449-020-02488-1
ELSA | DOI
 
[127]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser, A., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Frahm, B., Pörtner, R., … Möller, J. (2021). Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering, 44(4), 683–700. https://doi.org/10.1007/s00449-020-02478-3
ELSA | DOI
 
[126]
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Blome, A., Luttmann, M., Frahm, B., & Müller, U. (2021). Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. Presented at the Seminar Life Science Technologies, TH OWL, Lemgo, Germany.
ELSA
 
[125]
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
Möller, J., Hernández Rodríguez, T., Müller, J., Arndt, L., Kuchemüller, K. B., Frahm, B., … Pörtner, R. (2020). Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes. Computers & Chemical Engineering, 134, 1–13. https://doi.org/10.1016/j.compchemeng.2019.106693
ELSA | DOI
 
[124]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Hernández Rodríguez, T., & Frahm, B. (2020). Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols (Vol. 2095, pp. 251–267). Berlin, Heidelberg, New York: Springer. https://doi.org/10.1007/978-1-0716-0191-4_14
ELSA | DOI
 
[123]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
Deppe, S., Frahm, B., Hass, V. C., Hernández Rodríguez, T., Kuchemüller, K. B., Möller, J., & Pörtner, R. (2020). Estimation of Process Model Parameters. In R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols (Vol. 2095, pp. 213–234). Berlin ; Heidelberg ; New York: Springer. https://doi.org/10.1007/978-1-0716-0191-4_12
ELSA | DOI
 
[122]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, Claus , Pörtner, R., & Frahm, B. (2020). Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BMC Proceedings (Vol. 14, p. P408). Copenhagen, Denmark.: BioMed Central. https://doi.org/10.1186/s12919-020-00188-y
ELSA | Dateien verfügbar | DOI
 
[121]
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Deppe, S., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[120]
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe, S., Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Ifrim, G. A., … Frahm, B. (2020). Model-assisted Design of Experiments for algae cultivation. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[119]
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2020). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[118]
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[117]
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[116]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez, T., Frahm, B., & Posch, C. (2020). Integration of prior knowledge and digital tools for uncertainty-based decision support. Presented at the 1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable, Sandoz, Austria.
ELSA
 
[115]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1225 – 1226). Wiley. https://doi.org/10.1002/cite.202055235
ELSA | DOI
 
[114]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1241 – 1242). Wiley. https://doi.org/10.1002/cite.202055234
ELSA | DOI
 
[113]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, C., Pörtner, R., & Frahm, B. (2019). Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering, 116(11), 2944–2959. https://doi.org/10.1002/bit.27125
ELSA | DOI | Download (ext.)
 
[112]
2019 | Konferenzband - Beitrag | ELSA-ID: 2400
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Multivariable control strategy for the photosynthetic cultures of microalgae. 2019 23rd International Conference on System Theory, Control and Computing (ICSTCC). IEEE. https://doi.org/10.1109/icstcc.2019.8886109
ELSA | DOI
 
[111]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller, J., Müller, J., Hernández Rodriguez, T., Kuchemüller, K. B., Arndt, L., Frahm, B., … Pörtner, R. (2019). Workflow for model-assisted design and scale-up of biopharmaceutical production processes. Presented at the BioTech 2019 - Biopharmaceutical Manufacturing and Single-Use Technologies: Process intensification and continuous bioprocessing with single-use devices, Wädenswil, Switzerland.
ELSA
 
[110]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller, J., Kuchemüller, K. B., Moser, A., Hass, V. C., Hernández Rodriguez, T., Deppe, S., … Pörtner, R. (2019). Model-Assisted Design of Experiments. Presented at the 5th European Congress of Applied Biotechnology, Florence, Italy.
ELSA
 
[109]
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Novel control strategy for microalgae in photobioreactor. Presented at the 23rd International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania.
ELSA
 
[108]
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the BioProcessingDays 2019, Recklinghausen, Germany.
ELSA
 
[107]
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the 26th Meeting of the European Society for Animal Cell Technology (ESACT): Cell culture technologies: bridging academia and industry to provide solutions for patients, Copenhagen, Denmark.
ELSA
 
[106]
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Deppe, S., Ifrim, G. A., Moser, A., … Pörtner, R. (2019). Model-Assisted Design of Experiments – Software Toolbox. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[105]
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., Tölle, M., Kuhfuß, F., Möller, J., … Frahm, B. (2019). Model-assisted Design of Experiments for algae cultivation. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[104]
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2019). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[103]
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[102]
2019 | Konferenz - Poster | ELSA-ID: 3006
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Multivariable control strategy for the photosynthetic cultures of microalgae. Presented at the 23rd International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania.
ELSA
 
[101]
2019 | Konferenz - Vortrag | ELSA-ID: 7928
Frahm, B. (2019). Scale-up of stirred vessels. Presented at the International Week “Welfare and Responsibility,” SeAMK, Seinäjoki, Finnland.
ELSA
 
[100]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Frahm, B., Hass, V. C., & Pörtner, R. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review, 3, 39–41.
ELSA | Download (ext.)
 
[99]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2018). Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. BMC Proceedings (Vol. 112, p. P175). Lausanne, Switzerland: BioMed Central. https://doi.org/10.1186/s12919-018-0097-x
ELSA | Dateien verfügbar | DOI
 
[98]
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Pörtner, R., Möller, J., Frahm, B., & Hass, V. C. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. Presented at the Bioprocessing Summit Europe: Practical Solutions for Today’s Bioprocess Challenges, Lisbon, Portugal.
ELSA
 
[97]
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hernández Rodriguez, T., Frahm, B., … Pörtner, R. (2018). Model-Assisted Design and Optimization of Process Strategies. Presented at the BioProcessingDays 2018, Recklinghausen, Germany.
ELSA
 
[96]
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez, T., Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hass, V. C., … Pörtner, R. (2018). Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. Presented at the 5th BioProScale Symposium: Innovative scale up and scale down for bioprocess intensification, Berlin, Germany.
ELSA
 
[95]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez, T., Frahm, B., Posch, C., Schmutzhard, J., & Stettner, J. (2018). A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. Presented at the Sandoz, Kundl, Austria.
ELSA
 
[94]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez, T., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the 3. Lippischer Automatisierungstreff der Produktions- und Werkstofftechnik (LAT/PWT), Lemgo, Germany.
ELSA
 
[93]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner, R., Möller, J., Hernández Rodriguez, T., Frahm, B., & Hass, V. C. (2017). Model-assisted design and optimization of biotechnological processes. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
ELSA
 
[92]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez, T., Koopmann, K. S., Klaes, J., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the MATLAB EXPO, Track “Optimierungsaufgaben in der Praxis,” Munic, Germany.
ELSA
 
[91]
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez, T., Koopmann, K. S., Pörtner, R., & Frahm, B. (2017). Influence of parameter accuracies in cell culture seed train simulations. Presented at the BioProcessingDays 2017, Recklinghausen, Germany.
ELSA
 
[90]
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the 25th Meeting of the European Society for Animal Cell Technology (ESACT): Cell technologies for innovative therapies, Lausanne, Switzerland.
ELSA
 
[89]
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez, T., Krull, S., Hass, V. C., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production,” Neu-Ulm, Germany.
ELSA
 
[88]
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
Pörtner, R., Platas Barradas, O., Frahm, B., & Hass, V. C. (2016). Advanced Process and Control Strategies for Bioreactors. In Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls (pp. 463–493). Amsterdam: Elsevier. https://doi.org/10.1016/b978-0-444-63663-8.00016-1
ELSA | DOI
 
[87]
2016 | Konferenz - Poster | ELSA-ID: 2991
Beshay, U., Feldt, S., Schwarze, B., Wefing, P., Hahne, T., Moschinski, J., … Frahm, B. (2016). DMA Photobioreactor System – Cultivation at low shear stress and optional membrane aeration. Presented at the BioProcessingDays 2016, Recklinghausen, Germany.
ELSA
 
[86]
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez, T., Vörtler, S., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2016). A software tool for biopharmaceutical seed train design and optimization. Presented at the BioProcessingDays 2016, Recklinghausen, Germany.
ELSA
 
[85]
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann, K. S., Hernández Rodriguez, T., Vörtler, S., Beshay, U., Möller, J., Pörtner, R., & Frahm, B. (2016). Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. Presented at the DECHEMA Himmelfahrtstagung “New Frontiers for Biotech-Processes,” Koblenz, Germany.
ELSA
 
[84]
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Kern, S., Platas-Barradas, O., Pörtner, R., & Frahm, B. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Cytotechnology, 68(4), 1019–1032. https://doi.org/10.1007/s10616-015-9858-9
ELSA | DOI | Download (ext.)
 
[83]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. BMC proceedings / BioMed Central (Vol. 9). BioMed Central. https://doi.org/10.1186/1753-6561-9-s9-p43
ELSA | DOI | Download (ext.)
 
[82]
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 | OA
Kern, S., Platas Barradas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. BMC proceedings / BioMed Central (Vol. 9). BioMed Central. https://doi.org/10.1186/1753-6561-9-s9-p44
ELSA | DOI | Download (ext.)
 
[81]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm, B., Pörtner, R., Kern, S., & Hernández Rodriguez, T. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the ACHEMA 2015, Frankfurt am Main, Germany.
ELSA | Dateien verfügbar
 
[80]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm, B., Hernández Rodriguez, T., Kern, S., Koopmann, K. S., Beshay, U., Platas-Barradas, O., & Pörtner, R. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg, Germany.
ELSA
 
[79]
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses,” Hamburg, Germany.
ELSA
 
[78]
2015 | Konferenz - Poster | ELSA-ID: 2986
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Presented at the DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses,” Hamburg, Germany.
ELSA
 
[77]
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). A software tool for biopharmaceutical seed train design and optimization. Presented at the MATLAB EXPO, Munic, Germany.
ELSA
 
[76]
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the 24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products, Barcelona, Spain.
ELSA
 
[75]
2015 | Konferenz - Poster | ELSA-ID: 2990
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Presented at the 24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products, Barcelona, Spain.
ELSA
 
[74]
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Hahne, T., Schwarze, B., Kramer, M., & Frahm, B. (2014). Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags. Journal of Algal Biomass Utilization, 5(2), 66–73.
ELSA
 
[73]
2014 | Patent | ELSA-ID: 2878
Frahm, B., & Meier, U. (2014). Beleuchtung von disposable Bioreaktoren.
ELSA
 
[72]
2014 | Konferenz - Poster | ELSA-ID: 2984
Drews, F., Drews, G., Folz, C., Platz, G., Gassenmeier, T., Kramer, M., … Frahm, B. (2014). Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. Presented at the 7. Bundesalgenstammtisch, Köthen, Germany.
ELSA
 
[71]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. BMC proceedings / BioMed Central (Vol. 7). BioMed Central . https://doi.org/10.1186/1753-6561-7-s6-p9
ELSA | DOI | Download (ext.)
 
[70]
2013 | Konferenzband - Beitrag | ELSA-ID: 2818 | OA
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Model-based design of the first steps of a seed train for cell culture processes. BMC proceedings / BioMed Central (Vol. 7). BioMed Central. https://doi.org/10.1186/1753-6561-7-s6-p11
ELSA | DOI | Download (ext.)
 
[69]
2013 | Konferenz - Poster | ELSA-ID: 2980
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung “Effiziente Verfahren und Anlagen in der Bioverfahrenstechnik und Lebensmittelbiotechnologie,” Bad Wildungen, Germany.
ELSA
 
[68]
2013 | Konferenz - Poster | ELSA-ID: 2981
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Model-based design of the first steps of a seed train for cell culture processes. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.
ELSA
 
[67]
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne, T., Schwarze, B., Moschinski, J., Kuttig, A., Kramer, M., & Frahm, B. (2013). Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags. Presented at the 6. Bundesalgenstammtisch, Hamburg, Germany.
ELSA
 
[66]
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.
ELSA
 
[65]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 | OA
Frahm, B., & Brod, H. (2012). Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009 (Vol. 5, pp. 355–359). Dordrecht: Springer. https://doi.org/10.1007/978-94-007-0884-6_56
ELSA | DOI | Download (ext.)
 
[64]
2012 | Patent | ELSA-ID: 2877
Brod, H., & Frahm, B. (2012). Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.
ELSA
 
[63]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., & Ludwig, R. (2012). Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Achema 2012. Frankfurt am Main, Germany: Vogel Business Media.
ELSA
 
[62]
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui, R., Pörtner, R., & Frahm, B. (2012). Optimierung des Seed trains von Suspensions-Zellkulturen. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung “Biopharmazeutische Produktion,” Freiburg, Germany.
ELSA
 
[61]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., Dewulf, J., Van Langenhove, H., & Ludwig, R. (2011). A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic, 68(2), 154–161. https://doi.org/10.1016/j.molcatb.2010.10.004
ELSA | DOI | Download (ext.)
 
[60]
2011 | Patent | ELSA-ID: 2876
Brod, H., Frahm, B., Jenne, M., Kauling, J., Schmitt, F., & Seletzky, J. (2011). Flüssigkeitsbegaser.
ELSA
 
[59]
2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., & Ludwig, R. (2011). Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Presented at the 1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting, Berlin, Germany.
ELSA
 
[58]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Prague, CZ: Czech Society of Chemical Engineering.
ELSA
 
[57]
2010 | Patent | ELSA-ID: 2873
Brod, H., Frahm, B., & Kauling, J. (2010). Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.
ELSA
 
[56]
2010 | Patent | ELSA-ID: 2874
Brod, H., Frahm, B., Jenne, M., & Kauling, J. (2010). Bioreaktor.
ELSA
 
[55]
2010 | Patent | ELSA-ID: 2875
Frahm, B., Kauling, J., Pütz, A., & Schindler, M. (2010). Begasungssystem.
ELSA
 
[54]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm, B., & Brod, H. (2010). Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration. Presented at the 6th annual Optimizing Cell Culture Technology-Meeting as part of The Bioprocessing Summit - Practical Solutions for Today’s Laboratory Challenges, Boston, USA.
ELSA
 
[53]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). Intensified absorption and distillation devices for modular chemical production processes. Presented at the 19th International Congress of Chemical and Process Engineering, CHISA , Prague, Czech Republic.
ELSA
 
[52]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 | OA
Frahm, B., Brod, H., & Langer, U. (2009). Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology, 59(1), 17–30. https://doi.org/10.1007/s10616-009-9189-9
ELSA | DOI | Download (ext.)
 
[51]
2009 | Patent | ELSA-ID: 2872
Braun, A., Brod, H., Frahm, B., Jenne, M., Kauling, J., & Kirchner, S. (2009). Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.
ELSA
 
[50]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm, B., Brod, H., & Langer, U. (2009). Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). Presented at the Industrial Biotechnology Exhibition & Partnering Conference at ACHEMA , Frankfurt am Main, Germany.
ELSA
 
[49]
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm, B., Brod, H., & Langer, U. (2009). Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). Presented at the 21st Meeting of the European Society for Animal Cell Technology (ESACT): Cellular Solutions for Clinical Challenges, Dublin, Ireland.
ELSA
 
[48]
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke, W., Van Langenhovve, H., Frahm, B., Brod, H., Dewulf, J., Haltrich, D., & Ludwig, R. (2009). Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor. Presented at the COST 928 Control and exploitation of enzymes for added-value products, 3rd Annual Workshop, Krakow, Poland.
ELSA
 
[47]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod, H., Kauling, J., Frahm, B., Jenne, M., Langer, U., & Bödeker, B. (2008). Pushing the Limits in High-Density Mammalian Cell Fermentation. Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.
ELSA
 
[46]
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm, B., Brod, H., Burnett, M., Langer, U., & Bödeker, B. (2008). High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). Presented at the Bayer Science Day, Palladium, Cologne, Germany.
ELSA
 
[45]
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm, B., & Brod, H. (2008). High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.
ELSA
 
[44]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm, B., Kirchner, S., Kauling, J., Brod, H., Langer, U., & Bödeker, B. (2007). Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien. Chemie Ingenieur Technik, 79(7), 1052–1058. https://doi.org/10.1002/cite.200700070
ELSA | DOI | Download (ext.)
 
[43]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Pörtner, R., Frahm, B., Lane, P., Munack, A., Kühn, K., & Hass, V. C. (2007). Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller. Cell Technology for Cell Products (Vol. 3, pp. 497–501). Dordrecht: Springer. https://doi.org/10.1007/978-1-4020-5476-1_84
ELSA | DOI
 
[42]
2007 | Patent | ELSA-ID: 2870 | OA
Brod, H., Frahm, B., Kauling, J., & Rose, R. (2007). Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.
ELSA | Download (ext.)
 
[41]
2007 | Patent | ELSA-ID: 2871
Brod, H., Frahm, B., Kauling, J., Poggel, M., Rose, R., & Schmidt, S. (2007). Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.
ELSA
 
[40]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod, H., Frahm, B., & Kauling, J. (2007). Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. Presented at the GVC Fachausschuss Mischvorgänge, Würzburg, Germany.
ELSA
 
[39]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod, H., Frahm, B., & Kauling, J. (2007). Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung „Aufarbeitung biotechnologischer Produkte", Osnabrück, Germany.
ELSA
 
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