137 Publikationen

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[137]
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (2022). A systematic, model-based workflow for risk-based decision making in upstream development. Presented at the 5th annual Bioprocessing Summit Europe, Barcelona, Spain.
ELSA
 
[136]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7975
Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. Processes, Special Issue: “Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing,” 10(883). https://doi.org/10.3390/pr10050883
ELSA | DOI
 
[135]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier, V., Deppe, S., Hernández Rodriguez, T., Kuhfuß, F., Moser, A., Hass, V. C., … Frahm, B. (2022). Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology, 4, 102–119. https://doi.org/10.1016/j.crbiot.2022.01.005
ELSA | DOI
 
[134]
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser, A., Möller, J., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., … Hass, V. C. (2021). Model-assisted Design of Experiments - Concept, Software and Applications. Presented at the 24th International Congress of Chemical and Process Engineering, CHISA 2021, as a web conference, Prague, Czech Republic.
ELSA
 
[133]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
Fasse, S., Alarinta, J., Frahm, B., & Wirtanen, G. (2021). Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy, 2(4), 556–575. https://doi.org/10.3390/dairy2040044
ELSA | DOI
 
[132]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser, A., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Frahm, B., Pörtner, R., … Möller, J. (2021). Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering, 44(4), 683–700. https://doi.org/10.1007/s00449-020-02478-3
ELSA | DOI
 
[131]
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Blome, A., Luttmann, M., Frahm, B., & Müller, U. (2021). Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. Presented at the Seminar Life Science Technologies, TH OWL, Lemgo, Germany.
ELSA
 
[130]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7983
Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm, B. (2021). Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. Processes, Special Issue: “Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing,” 9(964). https://doi.org/10.3390/pr9060964
ELSA | DOI
 
[129]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez, T., & Frahm, B. (2021). Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. Presented at the International Week “Digitalization and Sustainability in Higher Education,” SeAMK, Seinäjoki, Finnland.
ELSA
 
[128]
2021 | Lexikoneintrag | ELSA-ID: 7939
Wirtanen, G., Alarinta, J., Frahm, B., & Fasse, S. (2021). Bovine Colostrum for Human Consumption. In MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science.
ELSA
 
[127]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez, T., & Frahm, B. (2021). Digital Seed Train Twins and Statistical Methods. In Advances in Biochemical Engineering/Biotechnology (p. 35). Berlin, Heidelberg: Springer. https://doi.org/10.1007/978-3-030-71660-8
ELSA | DOI
 
[126]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2021). Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering, 44(4), 793–808. https://doi.org/10.1007/s00449-020-02488-1
ELSA | DOI
 
[125]
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
Möller, J., Hernández Rodríguez, T., Müller, J., Arndt, L., Kuchemüller, K. B., Frahm, B., … Pörtner, R. (2020). Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes. Computers & Chemical Engineering, 134, 1–13. https://doi.org/10.1016/j.compchemeng.2019.106693
ELSA | DOI
 
[124]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Hernández Rodríguez, T., & Frahm, B. (2020). Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols (Vol. 2095, pp. 251–267). Berlin, Heidelberg, New York: Springer. https://doi.org/10.1007/978-1-0716-0191-4_14
ELSA | DOI
 
[123]
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2020). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[122]
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[121]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez, T., Frahm, B., & Posch, C. (2020). Integration of prior knowledge and digital tools for uncertainty-based decision support. Presented at the 1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable, Sandoz, Austria.
ELSA
 
[120]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1225 – 1226). Wiley. https://doi.org/10.1002/cite.202055235
ELSA | DOI
 
[119]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
Deppe, S., Frahm, B., Hass, V. C., Hernández Rodríguez, T., Kuchemüller, K. B., Möller, J., & Pörtner, R. (2020). Estimation of Process Model Parameters. In R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols (Vol. 2095, pp. 213–234). Berlin ; Heidelberg ; New York: Springer. https://doi.org/10.1007/978-1-0716-0191-4_12
ELSA | DOI
 
[118]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1241 – 1242). Wiley. https://doi.org/10.1002/cite.202055234
ELSA | DOI
 
[117]
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Deppe, S., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[116]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, Claus , Pörtner, R., & Frahm, B. (2020). Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BMC Proceedings (Vol. 14, p. P408). Copenhagen, Denmark.: BioMed Central. https://doi.org/10.1186/s12919-020-00188-y
ELSA | Dateien verfügbar | DOI
 
[115]
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe, S., Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Ifrim, G. A., … Frahm, B. (2020). Model-assisted Design of Experiments for algae cultivation. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[114]
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[113]
2019 | Konferenzband - Beitrag | ELSA-ID: 2400
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Multivariable control strategy for the photosynthetic cultures of microalgae. 2019 23rd International Conference on System Theory, Control and Computing (ICSTCC). IEEE. https://doi.org/10.1109/icstcc.2019.8886109
ELSA | DOI
 
[112]
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2019). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[111]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller, J., Müller, J., Hernández Rodriguez, T., Kuchemüller, K. B., Arndt, L., Frahm, B., … Pörtner, R. (2019). Workflow for model-assisted design and scale-up of biopharmaceutical production processes. Presented at the BioTech 2019 - Biopharmaceutical Manufacturing and Single-Use Technologies: Process intensification and continuous bioprocessing with single-use devices, Wädenswil, Switzerland.
ELSA
 
[110]
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the BioProcessingDays 2019, Recklinghausen, Germany.
ELSA
 
[109]
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[108]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller, J., Kuchemüller, K. B., Moser, A., Hass, V. C., Hernández Rodriguez, T., Deppe, S., … Pörtner, R. (2019). Model-Assisted Design of Experiments. Presented at the 5th European Congress of Applied Biotechnology, Florence, Italy.
ELSA
 
[107]
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the 26th Meeting of the European Society for Animal Cell Technology (ESACT): Cell culture technologies: bridging academia and industry to provide solutions for patients, Copenhagen, Denmark.
ELSA
 
[106]
2019 | Konferenz - Poster | ELSA-ID: 3006
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Multivariable control strategy for the photosynthetic cultures of microalgae. Presented at the 23rd International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania.
ELSA
 
[105]
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Novel control strategy for microalgae in photobioreactor. Presented at the 23rd International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania.
ELSA
 
[104]
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Deppe, S., Ifrim, G. A., Moser, A., … Pörtner, R. (2019). Model-Assisted Design of Experiments – Software Toolbox. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[103]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, C., Pörtner, R., & Frahm, B. (2019). Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering, 116(11), 2944–2959. https://doi.org/10.1002/bit.27125
ELSA | DOI | Download (ext.)
 
[102]
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., Tölle, M., Kuhfuß, F., Möller, J., … Frahm, B. (2019). Model-assisted Design of Experiments for algae cultivation. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[101]
2019 | Konferenz - Vortrag | ELSA-ID: 7928
Frahm, B. (2019). Scale-up of stirred vessels. Presented at the International Week “Welfare and Responsibility,” SeAMK, Seinäjoki, Finnland.
ELSA
 
[100]
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Pörtner, R., Möller, J., Frahm, B., & Hass, V. C. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. Presented at the Bioprocessing Summit Europe: Practical Solutions for Today’s Bioprocess Challenges, Lisbon, Portugal.
ELSA
 
[99]
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez, T., Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hass, V. C., … Pörtner, R. (2018). Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. Presented at the 5th BioProScale Symposium: Innovative scale up and scale down for bioprocess intensification, Berlin, Germany.
ELSA
 
[98]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Frahm, B., Hass, V. C., & Pörtner, R. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review, 3, 39–41.
ELSA | Download (ext.)
 
[97]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2018). Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. BMC Proceedings (Vol. 112, p. P175). Lausanne, Switzerland: BioMed Central. https://doi.org/10.1186/s12919-018-0097-x
ELSA | Dateien verfügbar | DOI
 
[96]
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hernández Rodriguez, T., Frahm, B., … Pörtner, R. (2018). Model-Assisted Design and Optimization of Process Strategies. Presented at the BioProcessingDays 2018, Recklinghausen, Germany.
ELSA
 
[95]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez, T., Frahm, B., Posch, C., Schmutzhard, J., & Stettner, J. (2018). A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. Presented at the Sandoz, Kundl, Austria.
ELSA
 
[94]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez, T., Koopmann, K. S., Klaes, J., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the MATLAB EXPO, Track “Optimierungsaufgaben in der Praxis,” Munic, Germany.
ELSA
 
[93]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez, T., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the 3. Lippischer Automatisierungstreff der Produktions- und Werkstofftechnik (LAT/PWT), Lemgo, Germany.
ELSA
 
[92]
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez, T., Koopmann, K. S., Pörtner, R., & Frahm, B. (2017). Influence of parameter accuracies in cell culture seed train simulations. Presented at the BioProcessingDays 2017, Recklinghausen, Germany.
ELSA
 
[91]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner, R., Möller, J., Hernández Rodriguez, T., Frahm, B., & Hass, V. C. (2017). Model-assisted design and optimization of biotechnological processes. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
ELSA
 
[90]
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the 25th Meeting of the European Society for Animal Cell Technology (ESACT): Cell technologies for innovative therapies, Lausanne, Switzerland.
ELSA
 
[89]
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez, T., Krull, S., Hass, V. C., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production,” Neu-Ulm, Germany.
ELSA
 
[88]
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann, K. S., Hernández Rodriguez, T., Vörtler, S., Beshay, U., Möller, J., Pörtner, R., & Frahm, B. (2016). Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. Presented at the DECHEMA Himmelfahrtstagung “New Frontiers for Biotech-Processes,” Koblenz, Germany.
ELSA
 
[87]
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
Pörtner, R., Platas Barradas, O., Frahm, B., & Hass, V. C. (2016). Advanced Process and Control Strategies for Bioreactors. In Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls (pp. 463–493). Amsterdam: Elsevier. https://doi.org/10.1016/b978-0-444-63663-8.00016-1
ELSA | DOI
 
[86]
2016 | Konferenz - Poster | ELSA-ID: 2991
Beshay, U., Feldt, S., Schwarze, B., Wefing, P., Hahne, T., Moschinski, J., … Frahm, B. (2016). DMA Photobioreactor System – Cultivation at low shear stress and optional membrane aeration. Presented at the BioProcessingDays 2016, Recklinghausen, Germany.
ELSA
 
[85]
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez, T., Vörtler, S., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2016). A software tool for biopharmaceutical seed train design and optimization. Presented at the BioProcessingDays 2016, Recklinghausen, Germany.
ELSA
 
[84]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm, B., Pörtner, R., Kern, S., & Hernández Rodriguez, T. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the ACHEMA 2015, Frankfurt am Main, Germany.
ELSA | Dateien verfügbar
 
[83]
2015 | Konferenz - Poster | ELSA-ID: 2986
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Presented at the DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses,” Hamburg, Germany.
ELSA
 
[82]
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). A software tool for biopharmaceutical seed train design and optimization. Presented at the MATLAB EXPO, Munic, Germany.
ELSA
 
[81]
2015 | Konferenzband - Beitrag | ELSA-ID: 2820
Kern, S., Platas Barradas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. BMC proceedings / BioMed Central (Vol. 9). BioMed Central. https://doi.org/10.1186/1753-6561-9-s9-p44
ELSA | DOI | Download (ext.)
 
[80]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm, B., Hernández Rodriguez, T., Kern, S., Koopmann, K. S., Beshay, U., Platas-Barradas, O., & Pörtner, R. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg, Germany.
ELSA
 
[79]
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the 24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products, Barcelona, Spain.
ELSA
 
[78]
2015 | Konferenz - Poster | ELSA-ID: 2990
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Presented at the 24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products, Barcelona, Spain.
ELSA
 
[77]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. BMC proceedings / BioMed Central (Vol. 9). BioMed Central. https://doi.org/10.1186/1753-6561-9-s9-p43
ELSA | DOI | Download (ext.)
 
[76]
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Kern, S., Platas-Barradas, O., Pörtner, R., & Frahm, B. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Cytotechnology, 68(4), 1019–1032. https://doi.org/10.1007/s10616-015-9858-9
ELSA | DOI | Download (ext.)
 
[75]
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses,” Hamburg, Germany.
ELSA
 
[74]
2014 | Patent | ELSA-ID: 2878
Frahm, B., & Meier, U. (2014). Beleuchtung von disposable Bioreaktoren.
ELSA
 
[73]
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Hahne, T., Schwarze, B., Kramer, M., & Frahm, B. (2014). Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags. Journal of Algal Biomass Utilization, 5(2), 66–73.
ELSA
 
[72]
2014 | Konferenz - Poster | ELSA-ID: 2984
Drews, F., Drews, G., Folz, C., Platz, G., Gassenmeier, T., Kramer, M., … Frahm, B. (2014). Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. Presented at the 7. Bundesalgenstammtisch, Köthen, Germany.
ELSA
 
[71]
2013 | Konferenz - Poster | ELSA-ID: 2981
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Model-based design of the first steps of a seed train for cell culture processes. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.
ELSA
 
[70]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. BMC proceedings / BioMed Central (Vol. 7). BioMed Central . https://doi.org/10.1186/1753-6561-7-s6-p9
ELSA | DOI | Download (ext.)
 
[69]
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne, T., Schwarze, B., Moschinski, J., Kuttig, A., Kramer, M., & Frahm, B. (2013). Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags. Presented at the 6. Bundesalgenstammtisch, Hamburg, Germany.
ELSA
 
[68]
2013 | Konferenzband - Beitrag | ELSA-ID: 2818
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Model-based design of the first steps of a seed train for cell culture processes. BMC proceedings / BioMed Central (Vol. 7). BioMed Central. https://doi.org/10.1186/1753-6561-7-s6-p11
ELSA | DOI | Download (ext.)
 
[67]
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.
ELSA
 
[66]
2013 | Konferenz - Poster | ELSA-ID: 2980
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung “Effiziente Verfahren und Anlagen in der Bioverfahrenstechnik und Lebensmittelbiotechnologie,” Bad Wildungen, Germany.
ELSA
 
[65]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816
Frahm, B., & Brod, H. (2012). Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009 (Vol. 5, pp. 355–359). Dordrecht: Springer. https://doi.org/10.1007/978-94-007-0884-6_56
ELSA | DOI | Download (ext.)
 
[64]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., & Ludwig, R. (2012). Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Achema 2012. Frankfurt am Main, Germany: Vogel Business Media.
ELSA
 
[63]
2012 | Patent | ELSA-ID: 2877
Brod, H., & Frahm, B. (2012). Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.
ELSA
 
[62]
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui, R., Pörtner, R., & Frahm, B. (2012). Optimierung des Seed trains von Suspensions-Zellkulturen. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung “Biopharmazeutische Produktion,” Freiburg, Germany.
ELSA
 
[61]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., Dewulf, J., Van Langenhove, H., & Ludwig, R. (2011). A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic, 68(2), 154–161. https://doi.org/10.1016/j.molcatb.2010.10.004
ELSA | DOI | Download (ext.)
 
[60]
2011 | Patent | ELSA-ID: 2876
Brod, H., Frahm, B., Jenne, M., Kauling, J., Schmitt, F., & Seletzky, J. (2011). Flüssigkeitsbegaser.
ELSA
 
[59]
2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., & Ludwig, R. (2011). Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Presented at the 1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting, Berlin, Germany.
ELSA
 
[58]
2010 | Patent | ELSA-ID: 2873
Brod, H., Frahm, B., & Kauling, J. (2010). Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.
ELSA
 
[57]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm, B., & Brod, H. (2010). Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration. Presented at the 6th annual Optimizing Cell Culture Technology-Meeting as part of The Bioprocessing Summit - Practical Solutions for Today’s Laboratory Challenges, Boston, USA.
ELSA
 
[56]
2010 | Patent | ELSA-ID: 2874
Brod, H., Frahm, B., Jenne, M., & Kauling, J. (2010). Bioreaktor.
ELSA
 
[55]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). Intensified absorption and distillation devices for modular chemical production processes. Presented at the 19th International Congress of Chemical and Process Engineering, CHISA , Prague, Czech Republic.
ELSA
 
[54]
2010 | Patent | ELSA-ID: 2875
Frahm, B., Kauling, J., Pütz, A., & Schindler, M. (2010). Begasungssystem.
ELSA
 
[53]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Prague, CZ: Czech Society of Chemical Engineering.
ELSA
 
[52]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm, B., Brod, H., & Langer, U. (2009). Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). Presented at the Industrial Biotechnology Exhibition & Partnering Conference at ACHEMA , Frankfurt am Main, Germany.
ELSA
 
[51]
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm, B., Brod, H., & Langer, U. (2009). Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). Presented at the 21st Meeting of the European Society for Animal Cell Technology (ESACT): Cellular Solutions for Clinical Challenges, Dublin, Ireland.
ELSA
 
[50]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349
Frahm, B., Brod, H., & Langer, U. (2009). Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology, 59(1), 17–30. https://doi.org/10.1007/s10616-009-9189-9
ELSA | DOI | Download (ext.)
 
[49]
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke, W., Van Langenhovve, H., Frahm, B., Brod, H., Dewulf, J., Haltrich, D., & Ludwig, R. (2009). Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor. Presented at the COST 928 Control and exploitation of enzymes for added-value products, 3rd Annual Workshop, Krakow, Poland.
ELSA
 
[48]
2009 | Patent | ELSA-ID: 2872
Braun, A., Brod, H., Frahm, B., Jenne, M., Kauling, J., & Kirchner, S. (2009). Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.
ELSA
 
[47]
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm, B., Brod, H., Burnett, M., Langer, U., & Bödeker, B. (2008). High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). Presented at the Bayer Science Day, Palladium, Cologne, Germany.
ELSA
 
[46]
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm, B., & Brod, H. (2008). High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.
ELSA
 
[45]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod, H., Kauling, J., Frahm, B., Jenne, M., Langer, U., & Bödeker, B. (2008). Pushing the Limits in High-Density Mammalian Cell Fermentation. Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.
ELSA
 
[44]
2007 | Konferenz - Poster | ELSA-ID: 2967
Frahm, B., Kirchner, S., Rose, R., Jenne, M., Kauling, J., Brod, H., … Bödeker, B. (2007). High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.
ELSA
 
[43]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm, B., Kirchner, S., Kauling, J., Brod, H., Langer, U., & Bödeker, B. (2007). Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien. Chemie Ingenieur Technik, 79(7), 1052–1058. https://doi.org/10.1002/cite.200700070
ELSA | DOI | Download (ext.)
 
[42]
2007 | Patent | ELSA-ID: 2870
Brod, H., Frahm, B., Kauling, J., & Rose, R. (2007). Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.
ELSA | Download (ext.)
 
[41]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Pörtner, R., Frahm, B., Lane, P., Munack, A., Kühn, K., & Hass, V. C. (2007). Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller. Cell Technology for Cell Products (Vol. 3, pp. 497–501). Dordrecht: Springer. https://doi.org/10.1007/978-1-4020-5476-1_84
ELSA | DOI
 
[40]
2007 | Patent | ELSA-ID: 2871
Brod, H., Frahm, B., Kauling, J., Poggel, M., Rose, R., & Schmidt, S. (2007). Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.
ELSA
 
[39]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod, H., Frahm, B., & Kauling, J. (2007). Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung „Aufarbeitung biotechnologischer Produkte", Osnabrück, Germany.
ELSA
 
[38]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod, H., Frahm, B., & Kauling, J. (2007). Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. Presented at the GVC Fachausschuss Mischvorgänge, Würzburg, Germany.
ELSA
 
[37]
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347
Frahm, B., Lane, P., Munack, A., & Pörtner, R. (2005). Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. Chemie Ingenieur Technik, 77(4), 429–435. https://doi.org/10.1002/cite.200407094
ELSA | DOI | Download (ext.)
 
[36]
2005 | Konferenzband - Beitrag | ELSA-ID: 2813
Frahm, B., & Pörtner, R. (2005). Flexible Fed-Batch Process Control of Animal Cells. Animal Cell Technology Meets Genomics (Vol. 2, pp. 693–695). Dordrecht: Springer. https://doi.org/10.1007/1-4020-3103-3_142
ELSA | DOI
 
[35]
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Pörtner, R., Frahm, B., Lane, P., & Munack, A. (2005). Optimisation of time-space-yield for hybridoma fed-batch cultures with an adaptive OLFO-controller. Presented at the 19th Meeting of the European Society for Animal Cell Technology (ESACT): Cell Technology for Cell Products, Harrogate, UK.
ELSA
 
[34]
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Pörtner, R., Frahm, B., Hass, V. C., Lane, P., & Munack, A. (2005). Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. Presented at the GVC / DECHEMA-Jahrestagungen 2005, Wiesbaden, Germany.
ELSA
 
[33]
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345
Pörtner, R., Schwabe, J.-O., & Frahm, B. (2004). Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line. Biotechnology and Applied Biochemistry, 40. https://doi.org/10.1042/ba20030168
ELSA | DOI | Download (ext.)
 
[32]
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Kühn, K., Frahm, B., Pörtner, R., Lane, P., Munack, A., & Hass, V. C. (2003). Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. (European Federation of Chemical Engineering, Ed.), ECCE - 4th European Congress of Chemical Engineering (Vol. 10). Granada: ECCE4.
ELSA
 
[31]
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Frahm, B., Lane, P., Munack, A., Hass, V. C., & Pörtner, R. (2003). Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies. Presented at the 27. ACHEMA 2003, Frankfurt am Main, Germany.
ELSA | Dateien verfügbar
 
[30]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343
Frahm, B., Hass, V. C., Lane, P., Munack, A., Märkl, H., & Pörtner, R. (2003). Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. Chemie Ingenieur Technik, 75(4), 457–460. https://doi.org/10.1002/cite.200390093
ELSA | DOI | Download (ext.)
 
[29]
2003 | Dissertation | ELSA-ID: 2393
Frahm, B. (2003). Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH.
ELSA
 
[28]
2003 | Konferenz - Vortrag | ELSA-ID: 2906
Pörtner, R., Frahm, B., Lane, P., Hass, V. C., Munack, A., & Märkl, H. (2003). Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung „Zellkulturen: Vom biologischen System zum Produktionsprozess“, Bad Dürkheim, Germany.
ELSA
 
[27]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344
Frahm, B., Lane, P., Märkl, H., & Pörtner, R. (2003). Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. Bioprocess and Biosystems Engineering, 26(1), 1–10. https://doi.org/10.1007/s00449-003-0335-z
ELSA | DOI | Download (ext.)
 
[26]
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Frahm, B., & Pörtner, R. (2003). Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung. Presented at the “Zellkultur-Tag”, Sartorius-College, Göttingen, Germany.
ELSA
 
[25]
2003 | Konferenz - Poster | ELSA-ID: 2964
Frahm, B., & Pörtner, R. (2003). CO2-off-gas measurement for animal cell culture processes. Presented at the 13th ESACT UK Meeting, Manchester, UK.
ELSA
 
[24]
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Frahm, B., & Pörtner, R. (2003). Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies. Presented at the 13th ESACT UK Meeting, Manchester, UK.
ELSA
 
[23]
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Hass, V. C., Kühn, K., Frahm, B., Pörtner, R., Lane, P., & Munack, A. (2003). Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung. Presented at the 21. DECHEMA-Jahrestagung der Biotechnologen, München.
ELSA
 
[22]
2003 | Konferenz - Poster | ELSA-ID: 2965
Frahm, B., & Pörtner, R. (2003). Flexible fed-batch process control of animal cells. Presented at the 18th Meeting of the European Society for Animal Cell Technology (ESACT): Animal Cell Technology Meets Genomics, Granada, Spain.
ELSA
 
[21]
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Frahm, B., Müller-Landré, B., Wiggers de Almeida, G., Singer, M., Rausch, M., Lane, P., … Pörtner, R. (2003). Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. (D. Beckmann & Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld), Eds.), Technische Systeme für Biotechnologie und Umwelt (pp. 503–509). Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik .
ELSA
 
[20]
2003 | Konferenz - Poster | ELSA-ID: 2966
Kühn, K., Frahm, B., Pörtner, R., Lane, P., Munack, A., & Hass, V. C. (2003). Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. Presented at the 4th European Congress on Chemical Engineering, Granada, Spain.
ELSA
 
[19]
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Frahm, B., & Pörtner, R. (2002). Reaktor-Abgasmessungen bei Zellkulturen. BIOforum, 4, 179–180.
ELSA
 
[18]
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Frahm, B., & Pörtner, R. (2002). Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. (H. Kaden & Forum Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung Biotechnologischer Prozesse (2001 : Waldheim), Eds.), Biosystemtechnik: Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung biotechnologischer Prozesse (pp. 39–48). Meinsberg : Kurt-Schwabe-Inst. .
ELSA
 
[17]
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Frahm, B., & Pörtner, R. (2002). Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. Presented at the DECHEMA Jahrestagung der Biotechnologen, Wiesbaden, Germany.
ELSA
 
[16]
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Frahm, B., Müller-Landré, B., Wiggers de Almeida, G., Singer, M., Rausch, M., Lane, P., … Pörtner, R. (2002). Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. Presented at the 11. Heiligenstädter Kolloquium, Technische Systeme für Biotechnologie und Umwelt, Heilbad Heiligenstadt, Germany.
ELSA
 
[15]
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Frahm, B., & Pörtner, R. (2002). Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells. Presented at the Seminar of the Lonza Biologics R&D Group, Lonza Biologics, Slough, UK.
ELSA
 
[14]
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Frahm, B., & Pörtner, R. (2002). Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells. Presented at the Seminar at the University of Birmingham, Birmingham, UK.
ELSA
 
[13]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340
Frahm, B., Blank, H.-C., Cornand, P., Oelßner, W., Guth, U., Lane, P., … Pörtner, R. (2002). Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement. Journal of Biotechnology, 99(2), 133–148. https://doi.org/10.1016/S0168-1656(02)00180-3
ELSA | DOI | Download (ext.)
 
[12]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341
Frahm, B., Lane, P., Atzert, H., Munack, A., Hoffmann, M., Hass, V. C., & Pörtner, R. (2002). Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells. Biotechnology Progress, 18(5), 1095–1103. https://doi.org/10.1021/bp020035y
ELSA | DOI | Download (ext.)
 
[11]
2001 | Konferenz - Poster | ELSA-ID: 2429
Hass, V. C., Lane, P., Hoffmann, M., Frahm, B., Schwabe, J.-O., Pörtner, R., & Munack, A. (2001). Model-Based Control of Hybridoma Cell Cultures. Presented at the 8th International Conference on Computer Applications in Biotechnology, Québec City, Québec, Canada.
ELSA
 
[10]
2001 | Konferenz - Poster | ELSA-ID: 2962
Frahm, B., Atzert, H., Lane, P., Hoffmann, M., Hass, V. C., Munack, A., & Pörtner, R. (2001). Development of an automated, model-based, adaptive control for the effective cultivation of hybridoma cells. Presented at the 17th Meeting of the European Society for Animal Cell Technology (ESACT): From Target to Market, Tylösand, Sweden.
ELSA
 
[9]
2001 | Konferenzband - Beitrag | ELSA-ID: 2963
Hass, V. C., Lane, P., Hoffmann, M., Frahm, B., Schwabe, J.-O., Pörtner, R., & Munack, A. (2001). Model-Based Control of Hybridoma Cell Cultures. (Published for the International Federation of Automatic Control by Pergamon , Ed.), Computer Applications in Biotechnology, 2001: Modelling, Monitoring and Control of Biotechnological Processes (Vol. 34, pp. 323–329). Oxford: ScienceDirect. https://doi.org/10.1016/S1474-6670(17)34240-4
ELSA | DOI | Download (ext.)
 
[8]
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Hoffmann, M., Hass, V. C., Frahm, B., Schwabe, J.-O., Pörtner, R., Lane, P., & Munack, A. (2001). Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen. Presented at the 19. DECHEMA Jahrestagung der Biotechnologen, Leipzig, Germany.
ELSA
 
[7]
2001 | Konferenz - Vortrag | ELSA-ID: 7933
Frahm, B., & Pörtner, R. (2001). Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. Presented at the Innovationsforum 2001 „Innovative Biosystemtechnik – Sensorik, Aktorik und Auswertung biotechnologischer Prozesse“, Waldheim, Germany.
ELSA
 
[6]
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
Frahm, B., Atzert, H., Lane, P., Hoffmann, M., Hass, V. C., Munack, A., & Pörtner, R. (2001). Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells. Animal Cell Technology: From Target to Market (Vol. 1, pp. 446–448). Dordrecht: Springer. https://doi.org/10.1007/978-94-010-0369-8_107
ELSA | DOI
 
[5]
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Frahm, B., & Pörtner, R. (2001). Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik. Presented at the Biotechnica, Hannover.
ELSA
 
[4]
2001 | Konferenz - Poster | ELSA-ID: 2960
Frahm, B., Atzert, H., Schwabe, J.-O., Lane, P., Munack, A., Hoffmann, M., … Pörtner, R. (2001). Adaptive modellgestützte Steuerung von Zellkulturprozessen. Presented at the 19. DECHEMA Jahrestagung der Biotechnologen, Leipzig, Germany.
ELSA
 
[3]
2001 | Konferenz - Poster | ELSA-ID: 2961
Lane, P., Frahm, B., Atzert, H., Schwabe, J.-O., Hoffmann, M., Hass, V. C., & Pörtner, R. (2001). Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities. Presented at the 19. DECHEMA Jahrestagung der Biotechnologen, Leipzig, Germany.
ELSA
 
[2]
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Anderelei, T., Frahm, B., & Büchs, J. (2000). Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren. Presented at the GVC-Fachausschusstagung Bioverfahrenstechnik, Bamberg, Germany.
ELSA
 
[1]
2000 | Konferenz - Poster | ELSA-ID: 2959
Hoffmann, M., Frahm, B., Schwabe, J.-O., Lane, P., Pörtner, R., Hass, V. C., & Munack, A. (2000). Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. Presented at the 10. Heiligenstädter Kolloquium, Technische Systeme für Biotechnologie und Umwelt, Heilbad Heiligenstadt, Germany.
ELSA
 

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[137]
2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez, T., Ramm, S., Lange-Hegermann, M., & Frahm, B. (2022). A systematic, model-based workflow for risk-based decision making in upstream development. Presented at the 5th annual Bioprocessing Summit Europe, Barcelona, Spain.
ELSA
 
[136]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7975
Hernández Rodriguez, T., Sekulic, A., Lange-Hegermann, M., & Frahm, B. (2022). Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design. Processes, Special Issue: “Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing,” 10(883). https://doi.org/10.3390/pr10050883
ELSA | DOI
 
[135]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier, V., Deppe, S., Hernández Rodriguez, T., Kuhfuß, F., Moser, A., Hass, V. C., … Frahm, B. (2022). Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology. Current Research in Biotechnology, 4, 102–119. https://doi.org/10.1016/j.crbiot.2022.01.005
ELSA | DOI
 
[134]
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser, A., Möller, J., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., … Hass, V. C. (2021). Model-assisted Design of Experiments - Concept, Software and Applications. Presented at the 24th International Congress of Chemical and Process Engineering, CHISA 2021, as a web conference, Prague, Czech Republic.
ELSA
 
[133]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
Fasse, S., Alarinta, J., Frahm, B., & Wirtanen, G. (2021). Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing. Dairy, 2(4), 556–575. https://doi.org/10.3390/dairy2040044
ELSA | DOI
 
[132]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser, A., Kuchemüller, K. B., Deppe, S., Hernández Rodriguez, T., Frahm, B., Pörtner, R., … Möller, J. (2021). Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. Bioprocess and Biosystems Engineering, 44(4), 683–700. https://doi.org/10.1007/s00449-020-02478-3
ELSA | DOI
 
[131]
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Blome, A., Luttmann, M., Frahm, B., & Müller, U. (2021). Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung. Presented at the Seminar Life Science Technologies, TH OWL, Lemgo, Germany.
ELSA
 
[130]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7983
Hernández Rodriguez, T., Morerod, S., Pörtner, R., Wurm, F. M., & Frahm, B. (2021). Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study. Processes, Special Issue: “Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing,” 9(964). https://doi.org/10.3390/pr9060964
ELSA | DOI
 
[129]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez, T., & Frahm, B. (2021). Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction. Presented at the International Week “Digitalization and Sustainability in Higher Education,” SeAMK, Seinäjoki, Finnland.
ELSA
 
[128]
2021 | Lexikoneintrag | ELSA-ID: 7939
Wirtanen, G., Alarinta, J., Frahm, B., & Fasse, S. (2021). Bovine Colostrum for Human Consumption. In MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science.
ELSA
 
[127]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez, T., & Frahm, B. (2021). Digital Seed Train Twins and Statistical Methods. In Advances in Biochemical Engineering/Biotechnology (p. 35). Berlin, Heidelberg: Springer. https://doi.org/10.1007/978-3-030-71660-8
ELSA | DOI
 
[126]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2021). Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train. Bioprocess and Biosystems Engineering, 44(4), 793–808. https://doi.org/10.1007/s00449-020-02488-1
ELSA | DOI
 
[125]
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
Möller, J., Hernández Rodríguez, T., Müller, J., Arndt, L., Kuchemüller, K. B., Frahm, B., … Pörtner, R. (2020). Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes. Computers & Chemical Engineering, 134, 1–13. https://doi.org/10.1016/j.compchemeng.2019.106693
ELSA | DOI
 
[124]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Hernández Rodríguez, T., & Frahm, B. (2020). Design, Optimization and Adaptive Control of Cell Culture Seed Trains. In R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols (Vol. 2095, pp. 251–267). Berlin, Heidelberg, New York: Springer. https://doi.org/10.1007/978-1-0716-0191-4_14
ELSA | DOI
 
[123]
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2020). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[122]
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[121]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez, T., Frahm, B., & Posch, C. (2020). Integration of prior knowledge and digital tools for uncertainty-based decision support. Presented at the 1st TRD (Technical Research & Development) Virtual Academia Strategic Roundtable, Sandoz, Austria.
ELSA
 
[120]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez, T., Deppe, S., Gassenmeier, V., Kuhfuß, F., Tölle, M., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1225 – 1226). Wiley. https://doi.org/10.1002/cite.202055235
ELSA | DOI
 
[119]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
Deppe, S., Frahm, B., Hass, V. C., Hernández Rodríguez, T., Kuchemüller, K. B., Möller, J., & Pörtner, R. (2020). Estimation of Process Model Parameters. In R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols (Vol. 2095, pp. 213–234). Berlin ; Heidelberg ; New York: Springer. https://doi.org/10.1007/978-1-0716-0191-4_12
ELSA | DOI
 
[118]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Chemie Ingenieur Technik, Tagungsband zur 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020 (Vol. No. 9, pp. 1241 – 1242). Wiley. https://doi.org/10.1002/cite.202055234
ELSA | DOI
 
[117]
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Deppe, S., Ifrim, G. A., & Frahm, B. (2020). Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[116]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, Claus , Pörtner, R., & Frahm, B. (2020). Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach. BMC Proceedings (Vol. 14, p. P408). Copenhagen, Denmark.: BioMed Central. https://doi.org/10.1186/s12919-020-00188-y
ELSA | Dateien verfügbar | DOI
 
[115]
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe, S., Kuhfuß, F., Tölle, M., Hernández Rodriguez, T., Gassenmeier, V., Ifrim, G. A., … Frahm, B. (2020). Model-assisted Design of Experiments for algae cultivation. Presented at the BioProcessingDays 2020, Recklinghausen, Germany.
ELSA
 
[114]
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez, T., Posch, C., Pörtner, R., & Frahm, B. (2020). Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes. Presented at the 10. ProcessNet-Jahrestagung und 34. DECHEMA-Jahrestagung der Biotechnologen 2020, als Web-Konferenz, Aachen, Germany.
ELSA
 
[113]
2019 | Konferenzband - Beitrag | ELSA-ID: 2400
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Multivariable control strategy for the photosynthetic cultures of microalgae. 2019 23rd International Conference on System Theory, Control and Computing (ICSTCC). IEEE. https://doi.org/10.1109/icstcc.2019.8886109
ELSA | DOI
 
[112]
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim, G. A., Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., & Frahm, B. (2019). Modeling of microalgae in an air-lift photobioreactor for biomass production. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[111]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller, J., Müller, J., Hernández Rodriguez, T., Kuchemüller, K. B., Arndt, L., Frahm, B., … Pörtner, R. (2019). Workflow for model-assisted design and scale-up of biopharmaceutical production processes. Presented at the BioTech 2019 - Biopharmaceutical Manufacturing and Single-Use Technologies: Process intensification and continuous bioprocessing with single-use devices, Wädenswil, Switzerland.
ELSA
 
[110]
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the BioProcessingDays 2019, Recklinghausen, Germany.
ELSA
 
[109]
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[108]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller, J., Kuchemüller, K. B., Moser, A., Hass, V. C., Hernández Rodriguez, T., Deppe, S., … Pörtner, R. (2019). Model-Assisted Design of Experiments. Presented at the 5th European Congress of Applied Biotechnology, Florence, Italy.
ELSA
 
[107]
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, J., Pörtner, R., & Frahm, B. (2019). Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating. Presented at the 26th Meeting of the European Society for Animal Cell Technology (ESACT): Cell culture technologies: bridging academia and industry to provide solutions for patients, Copenhagen, Denmark.
ELSA
 
[106]
2019 | Konferenz - Poster | ELSA-ID: 3006
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Multivariable control strategy for the photosynthetic cultures of microalgae. Presented at the 23rd International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania.
ELSA
 
[105]
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Ifrim, G. A., Titica, M., Deppe, S., Frahm, B., Barbu, M., & Caraman, S. (2019). Novel control strategy for microalgae in photobioreactor. Presented at the 23rd International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania.
ELSA
 
[104]
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Deppe, S., Ifrim, G. A., Moser, A., … Pörtner, R. (2019). Model-Assisted Design of Experiments – Software Toolbox. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[103]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391
Hernández Rodriguez, T., Posch, C., Schmutzhard, J., Stettner, J., Weihs, C., Pörtner, R., & Frahm, B. (2019). Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method. Biotechnology and Bioengineering, 116(11), 2944–2959. https://doi.org/10.1002/bit.27125
ELSA | DOI | Download (ext.)
 
[102]
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe, S., Hernández Rodriguez, T., Gassenmeier, V., Tölle, M., Kuhfuß, F., Möller, J., … Frahm, B. (2019). Model-assisted Design of Experiments for algae cultivation. Presented at the DECHEMA Himmelfahrtstagung “Intensification and digitalisation for integral bioprocessing,” Hamburg, Germany.
ELSA
 
[101]
2019 | Konferenz - Vortrag | ELSA-ID: 7928
Frahm, B. (2019). Scale-up of stirred vessels. Presented at the International Week “Welfare and Responsibility,” SeAMK, Seinäjoki, Finnland.
ELSA
 
[100]
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Pörtner, R., Möller, J., Frahm, B., & Hass, V. C. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. Presented at the Bioprocessing Summit Europe: Practical Solutions for Today’s Bioprocess Challenges, Lisbon, Portugal.
ELSA
 
[99]
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez, T., Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hass, V. C., … Pörtner, R. (2018). Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. Presented at the 5th BioProScale Symposium: Innovative scale up and scale down for bioprocess intensification, Berlin, Germany.
ELSA
 
[98]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390
Möller, J., Kuchemüller, K. B., Hernández Rodriguez, T., Frahm, B., Hass, V. C., & Pörtner, R. (2018). Model-Assisted Design of Process Strategies for Cell Culture Processes. American Pharmaceutical Review, 3, 39–41.
ELSA | Download (ext.)
 
[97]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2018). Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. BMC Proceedings (Vol. 112, p. P175). Lausanne, Switzerland: BioMed Central. https://doi.org/10.1186/s12919-018-0097-x
ELSA | Dateien verfügbar | DOI
 
[96]
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller, J., Kuchemüller, K. B., Freiberger, F., Levermann, P., Hernández Rodriguez, T., Frahm, B., … Pörtner, R. (2018). Model-Assisted Design and Optimization of Process Strategies. Presented at the BioProcessingDays 2018, Recklinghausen, Germany.
ELSA
 
[95]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez, T., Frahm, B., Posch, C., Schmutzhard, J., & Stettner, J. (2018). A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization. Presented at the Sandoz, Kundl, Austria.
ELSA
 
[94]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez, T., Koopmann, K. S., Klaes, J., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the MATLAB EXPO, Track “Optimierungsaufgaben in der Praxis,” Munic, Germany.
ELSA
 
[93]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez, T., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2017). Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. Presented at the 3. Lippischer Automatisierungstreff der Produktions- und Werkstofftechnik (LAT/PWT), Lemgo, Germany.
ELSA
 
[92]
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez, T., Koopmann, K. S., Pörtner, R., & Frahm, B. (2017). Influence of parameter accuracies in cell culture seed train simulations. Presented at the BioProcessingDays 2017, Recklinghausen, Germany.
ELSA
 
[91]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner, R., Möller, J., Hernández Rodriguez, T., Frahm, B., & Hass, V. C. (2017). Model-assisted design and optimization of biotechnological processes. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
ELSA
 
[90]
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez, T., Krull, S., Hass, V. C., Möller, J., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the 25th Meeting of the European Society for Animal Cell Technology (ESACT): Cell technologies for innovative therapies, Lausanne, Switzerland.
ELSA
 
[89]
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez, T., Krull, S., Hass, V. C., Pörtner, R., & Frahm, B. (2017). Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization. Presented at the DECHEMA Himmelfahrtstagung “Models for Developing and Optimising Biotech Production,” Neu-Ulm, Germany.
ELSA
 
[88]
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann, K. S., Hernández Rodriguez, T., Vörtler, S., Beshay, U., Möller, J., Pörtner, R., & Frahm, B. (2016). Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies. Presented at the DECHEMA Himmelfahrtstagung “New Frontiers for Biotech-Processes,” Koblenz, Germany.
ELSA
 
[87]
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
Pörtner, R., Platas Barradas, O., Frahm, B., & Hass, V. C. (2016). Advanced Process and Control Strategies for Bioreactors. In Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls (pp. 463–493). Amsterdam: Elsevier. https://doi.org/10.1016/b978-0-444-63663-8.00016-1
ELSA | DOI
 
[86]
2016 | Konferenz - Poster | ELSA-ID: 2991
Beshay, U., Feldt, S., Schwarze, B., Wefing, P., Hahne, T., Moschinski, J., … Frahm, B. (2016). DMA Photobioreactor System – Cultivation at low shear stress and optional membrane aeration. Presented at the BioProcessingDays 2016, Recklinghausen, Germany.
ELSA
 
[85]
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez, T., Vörtler, S., Kern, S., Platas Barradas, O., Pörtner, R., & Frahm, B. (2016). A software tool for biopharmaceutical seed train design and optimization. Presented at the BioProcessingDays 2016, Recklinghausen, Germany.
ELSA
 
[84]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm, B., Pörtner, R., Kern, S., & Hernández Rodriguez, T. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the ACHEMA 2015, Frankfurt am Main, Germany.
ELSA | Dateien verfügbar
 
[83]
2015 | Konferenz - Poster | ELSA-ID: 2986
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Presented at the DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses,” Hamburg, Germany.
ELSA
 
[82]
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). A software tool for biopharmaceutical seed train design and optimization. Presented at the MATLAB EXPO, Munic, Germany.
ELSA
 
[81]
2015 | Konferenzband - Beitrag | ELSA-ID: 2820
Kern, S., Platas Barradas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. BMC proceedings / BioMed Central (Vol. 9). BioMed Central. https://doi.org/10.1186/1753-6561-9-s9-p44
ELSA | DOI | Download (ext.)
 
[80]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm, B., Hernández Rodriguez, T., Kern, S., Koopmann, K. S., Beshay, U., Platas-Barradas, O., & Pörtner, R. (2015). Seed train design and optimization for animal cell suspension culture. Presented at the Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg, Germany.
ELSA
 
[79]
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the 24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products, Barcelona, Spain.
ELSA
 
[78]
2015 | Konferenz - Poster | ELSA-ID: 2990
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Presented at the 24th Meeting of the European Society for Animal Cell Technology (ESACT): C2P2: Cells, Culture, Patients, Products, Barcelona, Spain.
ELSA
 
[77]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. BMC proceedings / BioMed Central (Vol. 9). BioMed Central. https://doi.org/10.1186/1753-6561-9-s9-p43
ELSA | DOI | Download (ext.)
 
[76]
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Kern, S., Platas-Barradas, O., Pörtner, R., & Frahm, B. (2015). Model-based strategy for cell culture seed train layout verified at lab scale. Cytotechnology, 68(4), 1019–1032. https://doi.org/10.1007/s10616-015-9858-9
ELSA | DOI | Download (ext.)
 
[75]
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2015). Considerations for cell passaging in cell culture seed trains. Presented at the DECHEMA Himmelfahrtstagung “Scale-up and scale-down of bioprocesses,” Hamburg, Germany.
ELSA
 
[74]
2014 | Patent | ELSA-ID: 2878
Frahm, B., & Meier, U. (2014). Beleuchtung von disposable Bioreaktoren.
ELSA
 
[73]
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Hahne, T., Schwarze, B., Kramer, M., & Frahm, B. (2014). Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags. Journal of Algal Biomass Utilization, 5(2), 66–73.
ELSA
 
[72]
2014 | Konferenz - Poster | ELSA-ID: 2984
Drews, F., Drews, G., Folz, C., Platz, G., Gassenmeier, T., Kramer, M., … Frahm, B. (2014). Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. Presented at the 7. Bundesalgenstammtisch, Köthen, Germany.
ELSA
 
[71]
2013 | Konferenz - Poster | ELSA-ID: 2981
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Model-based design of the first steps of a seed train for cell culture processes. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.
ELSA
 
[70]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. BMC proceedings / BioMed Central (Vol. 7). BioMed Central . https://doi.org/10.1186/1753-6561-7-s6-p9
ELSA | DOI | Download (ext.)
 
[69]
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne, T., Schwarze, B., Moschinski, J., Kuttig, A., Kramer, M., & Frahm, B. (2013). Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags. Presented at the 6. Bundesalgenstammtisch, Hamburg, Germany.
ELSA
 
[68]
2013 | Konferenzband - Beitrag | ELSA-ID: 2818
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Model-based design of the first steps of a seed train for cell culture processes. BMC proceedings / BioMed Central (Vol. 7). BioMed Central. https://doi.org/10.1186/1753-6561-7-s6-p11
ELSA | DOI | Download (ext.)
 
[67]
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, T., Pörtner, R., & Frahm, B. (2013). Seed train optimization for suspension cell culture. Presented at the 23rd Meeting of the European Society for Animal Cell Technology (ESACT): Better Cells for Better Health, Lille, France.
ELSA
 
[66]
2013 | Konferenz - Poster | ELSA-ID: 2980
Kern, S., Platas, O., Schaletzky, M., Sandig, V., Frahm, B., & Pörtner, R. (2013). Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung “Effiziente Verfahren und Anlagen in der Bioverfahrenstechnik und Lebensmittelbiotechnologie,” Bad Wildungen, Germany.
ELSA
 
[65]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816
Frahm, B., & Brod, H. (2012). Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA). Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009 (Vol. 5, pp. 355–359). Dordrecht: Springer. https://doi.org/10.1007/978-94-007-0884-6_56
ELSA | DOI | Download (ext.)
 
[64]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., & Ludwig, R. (2012). Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Achema 2012. Frankfurt am Main, Germany: Vogel Business Media.
ELSA
 
[63]
2012 | Patent | ELSA-ID: 2877
Brod, H., & Frahm, B. (2012). Photobioreaktor mit rotatorisch oszillierenden Lichtquellen.
ELSA
 
[62]
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui, R., Pörtner, R., & Frahm, B. (2012). Optimierung des Seed trains von Suspensions-Zellkulturen. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung “Biopharmazeutische Produktion,” Freiburg, Germany.
ELSA
 
[61]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., Dewulf, J., Van Langenhove, H., & Ludwig, R. (2011). A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor. Journal of Molecular Catalysis B: Enzymatic, 68(2), 154–161. https://doi.org/10.1016/j.molcatb.2010.10.004
ELSA | DOI | Download (ext.)
 
[60]
2011 | Patent | ELSA-ID: 2876
Brod, H., Frahm, B., Jenne, M., Kauling, J., Schmitt, F., & Seletzky, J. (2011). Flüssigkeitsbegaser.
ELSA
 
[59]
2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., & Ludwig, R. (2011). Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor. Presented at the 1st European Congress of Applied Biotechnology together with DECHEMA’s Biotechnology Annual Meeting, Berlin, Germany.
ELSA
 
[58]
2010 | Patent | ELSA-ID: 2873
Brod, H., Frahm, B., & Kauling, J. (2010). Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen.
ELSA
 
[57]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm, B., & Brod, H. (2010). Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration. Presented at the 6th annual Optimizing Cell Culture Technology-Meeting as part of The Bioprocessing Summit - Practical Solutions for Today’s Laboratory Challenges, Boston, USA.
ELSA
 
[56]
2010 | Patent | ELSA-ID: 2874
Brod, H., Frahm, B., Jenne, M., & Kauling, J. (2010). Bioreaktor.
ELSA
 
[55]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). Intensified absorption and distillation devices for modular chemical production processes. Presented at the 19th International Congress of Chemical and Process Engineering, CHISA , Prague, Czech Republic.
ELSA
 
[54]
2010 | Patent | ELSA-ID: 2875
Frahm, B., Kauling, J., Pütz, A., & Schindler, M. (2010). Begasungssystem.
ELSA
 
[53]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks, B., Frahm, B., Grünewald, M., Kenig, E., Lautenschleger, A., Gorak, A., … Zecirovic, R. (2010). Intensified absorption and distillation devices for modular chemical production processes. Proceedings 19th International Congress of Chemical and Process Engineering. Prague, CZ: Czech Society of Chemical Engineering.
ELSA
 
[52]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm, B., Brod, H., & Langer, U. (2009). Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). Presented at the Industrial Biotechnology Exhibition & Partnering Conference at ACHEMA , Frankfurt am Main, Germany.
ELSA
 
[51]
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm, B., Brod, H., & Langer, U. (2009). Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA). Presented at the 21st Meeting of the European Society for Animal Cell Technology (ESACT): Cellular Solutions for Clinical Challenges, Dublin, Ireland.
ELSA
 
[50]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349
Frahm, B., Brod, H., & Langer, U. (2009). Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration. Cytotechnology, 59(1), 17–30. https://doi.org/10.1007/s10616-009-9189-9
ELSA | DOI | Download (ext.)
 
[49]
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke, W., Van Langenhovve, H., Frahm, B., Brod, H., Dewulf, J., Haltrich, D., & Ludwig, R. (2009). Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor. Presented at the COST 928 Control and exploitation of enzymes for added-value products, 3rd Annual Workshop, Krakow, Poland.
ELSA
 
[48]
2009 | Patent | ELSA-ID: 2872
Braun, A., Brod, H., Frahm, B., Jenne, M., Kauling, J., & Kirchner, S. (2009). Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen.
ELSA
 
[47]
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm, B., Brod, H., Burnett, M., Langer, U., & Bödeker, B. (2008). High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). Presented at the Bayer Science Day, Palladium, Cologne, Germany.
ELSA
 
[46]
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm, B., & Brod, H. (2008). High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.
ELSA
 
[45]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod, H., Kauling, J., Frahm, B., Jenne, M., Langer, U., & Bödeker, B. (2008). Pushing the Limits in High-Density Mammalian Cell Fermentation. Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.
ELSA
 
[44]
2007 | Konferenz - Poster | ELSA-ID: 2967
Frahm, B., Kirchner, S., Rose, R., Jenne, M., Kauling, J., Brod, H., … Bödeker, B. (2007). High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA). Presented at the Technology Colloquium, BayKomm, Leverkusen, Germany.
ELSA
 
[43]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm, B., Kirchner, S., Kauling, J., Brod, H., Langer, U., & Bödeker, B. (2007). Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien. Chemie Ingenieur Technik, 79(7), 1052–1058. https://doi.org/10.1002/cite.200700070
ELSA | DOI | Download (ext.)
 
[42]
2007 | Patent | ELSA-ID: 2870
Brod, H., Frahm, B., Kauling, J., & Rose, R. (2007). Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component.
ELSA | Download (ext.)
 
[41]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Pörtner, R., Frahm, B., Lane, P., Munack, A., Kühn, K., & Hass, V. C. (2007). Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller. Cell Technology for Cell Products (Vol. 3, pp. 497–501). Dordrecht: Springer. https://doi.org/10.1007/978-1-4020-5476-1_84
ELSA | DOI
 
[40]
2007 | Patent | ELSA-ID: 2871
Brod, H., Frahm, B., Kauling, J., Poggel, M., Rose, R., & Schmidt, S. (2007). Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.
ELSA
 
[39]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod, H., Frahm, B., & Kauling, J. (2007). Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung „Aufarbeitung biotechnologischer Produkte", Osnabrück, Germany.
ELSA
 
[38]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod, H., Frahm, B., & Kauling, J. (2007). Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. Presented at the GVC Fachausschuss Mischvorgänge, Würzburg, Germany.
ELSA
 
[37]
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347
Frahm, B., Lane, P., Munack, A., & Pörtner, R. (2005). Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. Chemie Ingenieur Technik, 77(4), 429–435. https://doi.org/10.1002/cite.200407094
ELSA | DOI | Download (ext.)
 
[36]
2005 | Konferenzband - Beitrag | ELSA-ID: 2813
Frahm, B., & Pörtner, R. (2005). Flexible Fed-Batch Process Control of Animal Cells. Animal Cell Technology Meets Genomics (Vol. 2, pp. 693–695). Dordrecht: Springer. https://doi.org/10.1007/1-4020-3103-3_142
ELSA | DOI
 
[35]
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Pörtner, R., Frahm, B., Lane, P., & Munack, A. (2005). Optimisation of time-space-yield for hybridoma fed-batch cultures with an adaptive OLFO-controller. Presented at the 19th Meeting of the European Society for Animal Cell Technology (ESACT): Cell Technology for Cell Products, Harrogate, UK.
ELSA
 
[34]
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Pörtner, R., Frahm, B., Hass, V. C., Lane, P., & Munack, A. (2005). Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. Presented at the GVC / DECHEMA-Jahrestagungen 2005, Wiesbaden, Germany.
ELSA
 
[33]
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345
Pörtner, R., Schwabe, J.-O., & Frahm, B. (2004). Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line. Biotechnology and Applied Biochemistry, 40. https://doi.org/10.1042/ba20030168
ELSA | DOI | Download (ext.)
 
[32]
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Kühn, K., Frahm, B., Pörtner, R., Lane, P., Munack, A., & Hass, V. C. (2003). Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. (European Federation of Chemical Engineering, Ed.), ECCE - 4th European Congress of Chemical Engineering (Vol. 10). Granada: ECCE4.
ELSA
 
[31]
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Frahm, B., Lane, P., Munack, A., Hass, V. C., & Pörtner, R. (2003). Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies. Presented at the 27. ACHEMA 2003, Frankfurt am Main, Germany.
ELSA | Dateien verfügbar
 
[30]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343
Frahm, B., Hass, V. C., Lane, P., Munack, A., Märkl, H., & Pörtner, R. (2003). Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung. Chemie Ingenieur Technik, 75(4), 457–460. https://doi.org/10.1002/cite.200390093
ELSA | DOI | Download (ext.)
 
[29]
2003 | Dissertation | ELSA-ID: 2393
Frahm, B. (2003). Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Norderstedt: Books on Demand GmbH.
ELSA
 
[28]
2003 | Konferenz - Vortrag | ELSA-ID: 2906
Pörtner, R., Frahm, B., Lane, P., Hass, V. C., Munack, A., & Märkl, H. (2003). Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung. Presented at the GVC / DECHEMA Vortrags- und Diskussionstagung „Zellkulturen: Vom biologischen System zum Produktionsprozess“, Bad Dürkheim, Germany.
ELSA
 
[27]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344
Frahm, B., Lane, P., Märkl, H., & Pörtner, R. (2003). Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis. Bioprocess and Biosystems Engineering, 26(1), 1–10. https://doi.org/10.1007/s00449-003-0335-z
ELSA | DOI | Download (ext.)
 
[26]
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Frahm, B., & Pörtner, R. (2003). Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung. Presented at the “Zellkultur-Tag”, Sartorius-College, Göttingen, Germany.
ELSA
 
[25]
2003 | Konferenz - Poster | ELSA-ID: 2964
Frahm, B., & Pörtner, R. (2003). CO2-off-gas measurement for animal cell culture processes. Presented at the 13th ESACT UK Meeting, Manchester, UK.
ELSA
 
[24]
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Frahm, B., & Pörtner, R. (2003). Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies. Presented at the 13th ESACT UK Meeting, Manchester, UK.
ELSA
 
[23]
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Hass, V. C., Kühn, K., Frahm, B., Pörtner, R., Lane, P., & Munack, A. (2003). Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung. Presented at the 21. DECHEMA-Jahrestagung der Biotechnologen, München.
ELSA
 
[22]
2003 | Konferenz - Poster | ELSA-ID: 2965
Frahm, B., & Pörtner, R. (2003). Flexible fed-batch process control of animal cells. Presented at the 18th Meeting of the European Society for Animal Cell Technology (ESACT): Animal Cell Technology Meets Genomics, Granada, Spain.
ELSA
 
[21]
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Frahm, B., Müller-Landré, B., Wiggers de Almeida, G., Singer, M., Rausch, M., Lane, P., … Pörtner, R. (2003). Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. (D. Beckmann & Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld), Eds.), Technische Systeme für Biotechnologie und Umwelt (pp. 503–509). Heiligenstadt: Inst. für Bioprozess- und Analysenmesstechnik .
ELSA
 
[20]
2003 | Konferenz - Poster | ELSA-ID: 2966
Kühn, K., Frahm, B., Pörtner, R., Lane, P., Munack, A., & Hass, V. C. (2003). Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. Presented at the 4th European Congress on Chemical Engineering, Granada, Spain.
ELSA
 
[19]
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Frahm, B., & Pörtner, R. (2002). Reaktor-Abgasmessungen bei Zellkulturen. BIOforum, 4, 179–180.
ELSA
 
[18]
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Frahm, B., & Pörtner, R. (2002). Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. (H. Kaden & Forum Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung Biotechnologischer Prozesse (2001 : Waldheim), Eds.), Biosystemtechnik: Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung biotechnologischer Prozesse (pp. 39–48). Meinsberg : Kurt-Schwabe-Inst. .
ELSA
 
[17]
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Frahm, B., & Pörtner, R. (2002). Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. Presented at the DECHEMA Jahrestagung der Biotechnologen, Wiesbaden, Germany.
ELSA
 
[16]
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Frahm, B., Müller-Landré, B., Wiggers de Almeida, G., Singer, M., Rausch, M., Lane, P., … Pörtner, R. (2002). Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control. Presented at the 11. Heiligenstädter Kolloquium, Technische Systeme für Biotechnologie und Umwelt, Heilbad Heiligenstadt, Germany.
ELSA
 
[15]
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Frahm, B., & Pörtner, R. (2002). Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells. Presented at the Seminar of the Lonza Biologics R&D Group, Lonza Biologics, Slough, UK.
ELSA
 
[14]
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Frahm, B., & Pörtner, R. (2002). Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells. Presented at the Seminar at the University of Birmingham, Birmingham, UK.
ELSA
 
[13]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340
Frahm, B., Blank, H.-C., Cornand, P., Oelßner, W., Guth, U., Lane, P., … Pörtner, R. (2002). Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement. Journal of Biotechnology, 99(2), 133–148. https://doi.org/10.1016/S0168-1656(02)00180-3
ELSA | DOI | Download (ext.)
 
[12]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341
Frahm, B., Lane, P., Atzert, H., Munack, A., Hoffmann, M., Hass, V. C., & Pörtner, R. (2002). Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells. Biotechnology Progress, 18(5), 1095–1103. https://doi.org/10.1021/bp020035y
ELSA | DOI | Download (ext.)
 
[11]
2001 | Konferenz - Poster | ELSA-ID: 2429
Hass, V. C., Lane, P., Hoffmann, M., Frahm, B., Schwabe, J.-O., Pörtner, R., & Munack, A. (2001). Model-Based Control of Hybridoma Cell Cultures. Presented at the 8th International Conference on Computer Applications in Biotechnology, Québec City, Québec, Canada.
ELSA
 
[10]
2001 | Konferenz - Poster | ELSA-ID: 2962
Frahm, B., Atzert, H., Lane, P., Hoffmann, M., Hass, V. C., Munack, A., & Pörtner, R. (2001). Development of an automated, model-based, adaptive control for the effective cultivation of hybridoma cells. Presented at the 17th Meeting of the European Society for Animal Cell Technology (ESACT): From Target to Market, Tylösand, Sweden.
ELSA
 
[9]
2001 | Konferenzband - Beitrag | ELSA-ID: 2963
Hass, V. C., Lane, P., Hoffmann, M., Frahm, B., Schwabe, J.-O., Pörtner, R., & Munack, A. (2001). Model-Based Control of Hybridoma Cell Cultures. (Published for the International Federation of Automatic Control by Pergamon , Ed.), Computer Applications in Biotechnology, 2001: Modelling, Monitoring and Control of Biotechnological Processes (Vol. 34, pp. 323–329). Oxford: ScienceDirect. https://doi.org/10.1016/S1474-6670(17)34240-4
ELSA | DOI | Download (ext.)
 
[8]
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Hoffmann, M., Hass, V. C., Frahm, B., Schwabe, J.-O., Pörtner, R., Lane, P., & Munack, A. (2001). Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen. Presented at the 19. DECHEMA Jahrestagung der Biotechnologen, Leipzig, Germany.
ELSA
 
[7]
2001 | Konferenz - Vortrag | ELSA-ID: 7933
Frahm, B., & Pörtner, R. (2001). Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. Presented at the Innovationsforum 2001 „Innovative Biosystemtechnik – Sensorik, Aktorik und Auswertung biotechnologischer Prozesse“, Waldheim, Germany.
ELSA
 
[6]
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
Frahm, B., Atzert, H., Lane, P., Hoffmann, M., Hass, V. C., Munack, A., & Pörtner, R. (2001). Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells. Animal Cell Technology: From Target to Market (Vol. 1, pp. 446–448). Dordrecht: Springer. https://doi.org/10.1007/978-94-010-0369-8_107
ELSA | DOI
 
[5]
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Frahm, B., & Pörtner, R. (2001). Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik. Presented at the Biotechnica, Hannover.
ELSA
 
[4]
2001 | Konferenz - Poster | ELSA-ID: 2960
Frahm, B., Atzert, H., Schwabe, J.-O., Lane, P., Munack, A., Hoffmann, M., … Pörtner, R. (2001). Adaptive modellgestützte Steuerung von Zellkulturprozessen. Presented at the 19. DECHEMA Jahrestagung der Biotechnologen, Leipzig, Germany.
ELSA
 
[3]
2001 | Konferenz - Poster | ELSA-ID: 2961
Lane, P., Frahm, B., Atzert, H., Schwabe, J.-O., Hoffmann, M., Hass, V. C., & Pörtner, R. (2001). Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities. Presented at the 19. DECHEMA Jahrestagung der Biotechnologen, Leipzig, Germany.
ELSA
 
[2]
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Anderelei, T., Frahm, B., & Büchs, J. (2000). Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren. Presented at the GVC-Fachausschusstagung Bioverfahrenstechnik, Bamberg, Germany.
ELSA
 
[1]
2000 | Konferenz - Poster | ELSA-ID: 2959
Hoffmann, M., Frahm, B., Schwabe, J.-O., Lane, P., Pörtner, R., Hass, V. C., & Munack, A. (2000). Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. Presented at the 10. Heiligenstädter Kolloquium, Technische Systeme für Biotechnologie und Umwelt, Heilbad Heiligenstadt, Germany.
ELSA
 

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