Seed Train Optimization for Cell Culture

B. Frahm, in: Animal Cell Biotechnology, Humana Press, Totowa, NJ, 2013, pp. 355–367.

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DOI
10.1007/978-1-62703-733-4_22
Sammelwerk - Beitrag | Veröffentlicht | Englisch
Autor*in
Einrichtung
FB4 - Labor/Technika Biotechnologie
Abstract
For the production of biopharmaceuticals a seed train is required to generate an adequate number of cells for inoculation of the production bioreactor. This seed train is time- and cost-intensive but offers potential for optimization. A method and a protocol are described for the seed train mapping, directed modeling without major effort, and its optimization regarding selected optimization criteria such as optimal points in time for cell passaging. Furthermore, the method can also be applied for the set-up of a new seed train, for example for a new cell line. Although the chapter is directed towards suspension cell lines, the method is also generally applicable, e.g. for adherent cell lines.
Stichworte
Seed train Optimization Modeling Prediction Space-Time-Yield (STY) Systems approach Bioinformatics Computational biotechnology Suspension Production
Erscheinungsjahr
2013
Buchtitel
Animal Cell Biotechnology
Band
1104
Seite
355-367
ISBN
9781627037327
eISBN
9781627037334
ISSN
1064-3745, 1940-6029
ELSA-ID

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Frahm B. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology. Vol 1104. Methods in Molecular Biology . Totowa, NJ: Humana Press; 2013:355-367. doi:10.1007/978-1-62703-733-4_22
Frahm, B. (2013). Seed Train Optimization for Cell Culture. In Animal Cell Biotechnology (Vol. 1104, pp. 355–367). Totowa, NJ: Humana Press. https://doi.org/10.1007/978-1-62703-733-4_22
Frahm B (2013) Seed Train Optimization for Cell Culture. Animal Cell Biotechnology, vol. 1104. Totowa, NJ: Humana Press, pp. 355–367.
Frahm, Björn. “Seed Train Optimization for Cell Culture.” In Animal Cell Biotechnology, 1104:355–67. Methods in Molecular Biology . Totowa, NJ: Humana Press, 2013. https://doi.org/10.1007/978-1-62703-733-4_22.
Frahm, Björn. 2013. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology, 1104:355–367. Methods in Molecular Biology . Totowa, NJ: Humana Press. doi:10.1007/978-1-62703-733-4_22, .
Frahm, Björn: Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology, Methods in Molecular Biology . Bd. 1104. Totowa, NJ : Humana Press, 2013, S. 355–367
B. Frahm, Seed Train Optimization for Cell Culture, in: Animal Cell Biotechnology, Humana Press, Totowa, NJ, 2013: pp. 355–367.
B. Frahm, “Seed Train Optimization for Cell Culture,” in Animal Cell Biotechnology, vol. 1104, Totowa, NJ: Humana Press, 2013, pp. 355–367.
Frahm, Björn. “Seed Train Optimization for Cell Culture.” Animal Cell Biotechnology, vol. 1104, Humana Press, 2013, pp. 355–67, doi:10.1007/978-1-62703-733-4_22.
Frahm, Björn (2013): Seed Train Optimization for Cell Culture, in: Animal Cell Biotechnology (=Methods in Molecular Biology 1104), Totowa, NJ, S. 355–367.
Frahm B. Seed Train Optimization for Cell Culture. In: Animal Cell Biotechnology. Totowa, NJ: Humana Press; 2013. p. 355–67. (Methods in Molecular Biology ; vol. 1104).

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