168 Publikationen
2024 | Konferenz - Vortrag | ELSA-ID: 12021
Segermann, Jan, et al. Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie. 2024.
ELSA
2024 | Konferenz - Vortrag | ELSA-ID: 12022
Luttmann, Mario, et al. Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen. 2024.
ELSA
2024 | Konferenz - Poster | ELSA-ID: 12395
Müller, Carolin, et al. Investigation of Microbial Spoilage in Vegan Foods. 2024.
ELSA
2024 | Konferenz - Poster | ELSA-ID: 12396
Gassenmeier, Veronika, et al. Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-Situ Monitoring of Hybridoma Cell Culture. 2024.
ELSA
2024 | Konferenz - Poster | ELSA-ID: 12397
Blome, André, et al. Process Optimization in Baked Goods Production Using Inline Sensors and Objective Product Evaluation. 2024.
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2024 | Preprint | ELSA-ID: 12400 |

Ramm, Selina, et al. Semi-Automated vs. Manual: Comparative Study of Cell Culture Counting Methods Using Validation Parameters. bioRxiv, 2024, https://doi.org/10.1101/2024.05.30.596619.
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2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Kosse, Pascal, et al. “Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.” Chemie Ingenieur Technik, vol. 96, no. 4, 2024, pp. 528–34, https://doi.org/10.1002/cite.202300188.
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2024 | Konferenz - Poster | ELSA-ID: 10957
Reinhardt, Lena, et al. Mycelium-Based Materials from Residues of the Regional Wood Industry.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 12483
Blome, André, et al. Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. 2023.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 12485
Luttmann, Mario, et al. Teig 4.0 - Promotionsthemen. 2023.
ELSA
2023 | Konferenz - Vortrag | ELSA-ID: 11109
Blome, André, et al. Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung. 2023.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11110
Blome, André, et al. Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. 2023.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11378
Gassenmeier, Veronika, et al. Real-Time Monitoring of DCO2 in Addition to DO.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11381
Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11382 |

Gassenmeier, Veronika, et al. View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks.
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2023 | Konferenz - Vortrag | ELSA-ID: 11383
Hernández Rodriguez, Tanja, et al. Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V., 2023.
ELSA
2023 | Konferenzband - Beitrag | ELSA-ID: 11384 |

Müller, Carolin, et al. “Microbial Spoilage in Vegan Foods.” Proceedings of the 10th International Congress of Food Technologists, Biotechnologists and Nutritionists: Smart Food for a Healthy Planet and Human Prosperity, Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023, pp. 64–67.
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2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Kosse, Pascal, et al. “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations.” Chemie Ingenieur Technik, vol. 95, no. 12, 2023, pp. 1960–69, https://doi.org/10.1002/cite.202300082.
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2023 | Konferenz - Poster | ELSA-ID: 11487 |

Ramm, Selina, et al. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.
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2023 | Konferenz - Poster | ELSA-ID: 10201 |

Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. 2023.
ELSA
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2023 | Konferenzband - Beitrag | ELSA-ID: 10788 |

Ramm, Selina, et al. “Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities.” 2023 IEEE 21st International Conference on Industrial Informatics (INDIN), edited by Jürgen Jasperneite et al., IEEE, 2023, pp. 1–6, https://doi.org/10.1109/INDIN51400.2023.10218012.
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2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Processes, vol. 10, no. 5, 883, 2022, https://doi.org/10.3390/pr10050883.
ELSA
| DOI
2022 | Datenpublikation | ELSA-ID: 10190
Gassenmeier, Veronika, and Björn Frahm. Real-Time Monitoring of DCO2 in Addition to DO. assets-labs, 2022.
ELSA
| Dateien verfügbar
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, edited by Ralf Pörtner and Johannes Möller, vol. special issue, MDPI, 2022, pp. 21–48, https://doi.org/10.3390/pr10050883.
ELSA
| DOI
2022 | Konferenzband - Beitrag | ELSA-ID: 10195
Blome, André, et al. “Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products.” Proceedings of the 33rd VH Yeast Conference 2022: Advances in Applied Research & Industrial Production of Baker’s Yeast, “100th Anniversary of VH Berlin & Yeast(s) as an Alternative Protein Source,” Versuchsanstalt der Hefeindustrie e.V., 2022, pp. 61–66.
ELSA
2022 | Konferenz - Vortrag | ELSA-ID: 10196
Blome, André, et al. Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products. 2022.
ELSA
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez, Tanja, et al. “Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture.” ACHEMA 2022, 2022.
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion.
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10199 |

Müller, Carolin, et al. “Microbial Spoilage in Vegan Foods.” PBN 2022 Congress, 2022.
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2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development.
ELSA
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier, Veronika, et al. “Model-Assisted DoE Applied to Microalgae Processes, Current Research in Biotechnology.” Current Research in Biotechnology, vol. 4, 2022, pp. 102–19, https://doi.org/10.1016/j.crbiot.2022.01.005.
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2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
Kuhfuß, Fabian, et al. “View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks.” Bioprocess and Biosystems Engineering, vol. 45, 2022, pp. 15–30, https://doi.org/10.1007/s00449-021-02627-2.
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study.” Processes, vol. 9, no. 6, 964, 2021, https://doi.org/10.3390/pr9060964.
ELSA
| DOI
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins and Statistical Methods.” Digital Twins Tools and Concepts for Smart Biomanufacturing, edited by Christoph Herwig et al., vol. 176, Springer, 2021, pp. 97–131, https://doi.org/10.1007/10_2020_137.
ELSA
| DOI
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez, Tanja, and Björn Frahm. Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction. 2021.
ELSA
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser, André, et al. Model-Assisted Design of Experiments - Concept, Software and Applications. 2021.
ELSA
2021 | Lexikoneintrag | ELSA-ID: 7939
Wirtanen, Gun, et al. “Bovine Colostrum for Human Consumption.” MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021.
ELSA
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
Fasse, Sylvia, et al. “Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing.” Dairy, vol. 2, no. 4, 2021, pp. 556–75, https://doi.org/10.3390/dairy2040044.
ELSA
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| WoS
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study.” Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue, MDPI, 2021, pp. 49–74, https://doi.org/10.3390/pr9060964.
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez, Tanja, et al. “Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train.” Bioprocess and Biosystems Engineering, vol. 44, no. 4, 2021, pp. 793–808, https://doi.org/10.1007/s00449-020-02488-1 .
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser, André, et al. “Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses.” Bioprocess and Biosystems Engineering, vol. 44, no. 4, 2021, pp. 683–700, https://doi.org/10.1007/s00449-020-02478-3.
ELSA
| DOI
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Blome, André, et al. “Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung.” Seminar Life Science Technologies 2021-04-28, 2021.
ELSA
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
Möller, Johannes, et al. “Model Uncertainty-Based Evaluation of Process Strategies during Scale-up of Biopharmaceutical Processes.” Computers & Chemical Engineering, vol. 134, Elsevier, 2020, pp. 1–13, doi:10.1016/j.compchemeng.2019.106693.
ELSA
| DOI
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Hernández Rodríguez, Tanja, and Björn Frahm. “Design, Optimization and Adaptive Control of Cell Culture Seed Trains.” Animal Cell Biotechnology - Methods and Protocols, edited by Ralf Pörtner, vol. 2095, Springer, 2020, pp. 251–67, doi:10.1007/978-1-0716-0191-4_14.
ELSA
| DOI
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
Deppe, S., et al. “Estimation of Process Model Parameters.” Animal Cell Biotechnology: Methods and Protocols, edited by Ralf Pörtner, vol. 2095, Springer, 2020, pp. 213–34, doi:10.1007/978-1-0716-0191-4_12.
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez, Tanja, et al. “Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach.” BMC Proceedings, vol. 14, BioMed Central, 2020, p. P408, doi:10.1186/s12919-020-00188-y.
ELSA
| Dateien verfügbar
| DOI
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß, F., et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe, S., et al. Model-Assisted Design of Experiments for Algae Cultivation. 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim, George Adrian, et al. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez, Tanja, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez, Tanja, et al. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. 2020.
ELSA
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez, Tanja, et al. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support. 2020.
ELSA
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez, Tanja, et al. “Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration.” Chemie Ingenieur Technik, Tagungsband Zur 10. ProcessNet-Jahrestagung Und 34. DECHEMA-Jahrestagung Der Biotechnologen 2020, vol. No. 9, Wiley, 2020, pp. 1225 – 1226, doi:10.1002/cite.202055235.
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez, Tanja, et al. “Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes.” Chemie Ingenieur Technik, Tagungsband Zur 10. ProcessNet-Jahrestagung Und 34. DECHEMA-Jahrestagung Der Biotechnologen 2020, vol. No. 9, Wiley, 2020, pp. 1241 – 1242, doi:10.1002/cite.202055234.
ELSA
| DOI
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 |

Hernández Rodriguez, Tanja, et al. “Predicting Industrial‐scale Cell Culture Seed Trains–A Bayesian Framework for Model Fitting and Parameter Estimation, Dealing with Uncertainty in Measurements and Model Parameters, Applied to a Nonlinear Kinetic Cell Culture Model, Using an MCMC Method.” Biotechnology and Bioengineering, vol. 116, no. 11, Wiley, 2019, pp. 2944–59, doi:10.1002/bit.27125.
ELSA
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2019 | Konferenzband - Beitrag | ELSA-ID: 2400
Ifrim, George Adrian, et al. “Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae.” 2019 23rd International Conference on System Theory, Control and Computing (ICSTCC), IEEE, 2019, doi:10.1109/icstcc.2019.8886109.
ELSA
| DOI
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller, J., et al. Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes. 2019.
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller, J., et al. Model-Assisted Design of Experiments. 2019.
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Ifrim, George Adrian, et al. Novel Control Strategy for Microalgae in Photobioreactor. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez, Tanja, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez, Tanja, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller, J., et al. Model-Assisted Design of Experiments – Software Toolbox. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe, S., et al. Model-Assisted Design of Experiments for Algae Cultivation. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim, George Adrian, et al. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez, Tanja, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3006
Ifrim, George Adrian, et al. Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae. 2019.
ELSA
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 |

Möller, J., et al. “Model-Assisted Design of Process Strategies for Cell Culture Processes.” American Pharmaceutical Review, vol. 3, Russel, 2018, pp. 39–41.
ELSA
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2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez, Tanja, et al. “Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization.” BMC Proceedings, vol. 112, BioMed Central, 2018, p. P175, doi:10.1186/s12919-018-0097-x.
ELSA
| Dateien verfügbar
| DOI
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Pörtner, R., et al. Model-Assisted Design of Process Strategies for Cell Culture Processes. 2018.
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller, J., et al. Model-Assisted Design and Optimization of Process Strategies. 2018.
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez, Tanja, et al. Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. 2018.
ELSA
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez, Tanja, et al. A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization. 2018.
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez, Tanja, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017.
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner, R., et al. Model-Assisted Design and Optimization of Biotechnological Processes. 2017.
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez, Tanja, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez, Tanja, et al. Influence of Parameter Accuracies in Cell Culture Seed Train Simulations. 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez, Tanja, et al. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez, Tanja, et al. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. 2017.
ELSA
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
Pörtner, R., et al. “Advanced Process and Control Strategies for Bioreactors.” Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls, Elsevier, 2016, pp. 463–93, doi:10.1016/b978-0-444-63663-8.00016-1.
ELSA
| DOI
2016 | Konferenz - Poster | ELSA-ID: 2991
Beshay, U., et al. DMA Photobioreactor System – Cultivation at Low Shear Stress and Optional Membrane Aeration. 2016.
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez, Tanja, et al. A Software Tool for Biopharmaceutical Seed Train Design and Optimization. 2016.
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann, K. S., et al. Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies. 2016.
ELSA
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Kern, Simon, et al. “Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale.” Cytotechnology, vol. 68, no. 4, Springer, 2015, pp. 1019–32, doi:10.1007/s10616-015-9858-9.
ELSA
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2015 | Konferenzband - Beitrag | ELSA-ID: 2819 |

Hernández Rodriguez, Tanja, et al. “Considerations for Cell Passaging in Cell Culture Seed Trains.” BMC Proceedings / BioMed Central, vol. 9, BioMed Central, 2015, doi:10.1186/1753-6561-9-s9-p43.
ELSA
| DOI
| Download (ext.)
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 |

Kern, Simon, et al. “Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale.” BMC Proceedings / BioMed Central, vol. 9, BioMed Central, 2015, doi:10.1186/1753-6561-9-s9-p44.
ELSA
| DOI
| Download (ext.)
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm, Björn, et al. Seed Train Design and Optimization for Animal Cell Suspension Culture. 2015.
ELSA
| Dateien verfügbar
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm, Björn, et al. Seed Train Design and Optimization for Animal Cell Suspension Culture. 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez, Tanja, et al. Considerations for Cell Passaging in Cell Culture Seed Trains. 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2986
Kern, S., et al. Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez, Tanja, et al. A Software Tool for Biopharmaceutical Seed Train Design and Optimization. 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez, Tanja, et al. Considerations for Cell Passaging in Cell Culture Seed Trains. 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2990
Kern, S., et al. Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. 2015.
ELSA
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Hahne, T., et al. “Disposable Algae Cultivation for High-Value Products Using All around LED-Illumination Directly on the Bags.” Journal of Algal Biomass Utilization, vol. 5, no. 2, PHYCO SPECTRUM, 2014, pp. 66–73.
ELSA
2014 | Patent | ELSA-ID: 2878
Frahm, Björn, and Uwe Meier. Beleuchtung von Disposable Bioreaktoren. 2014.
ELSA
2014 | Konferenz - Poster | ELSA-ID: 2984
Drews, F., et al. Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. 2014.
ELSA
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 |

Hernández Rodriguez, Tanja, et al. “Seed Train Optimization for Suspension Cell Culture.” BMC Proceedings / BioMed Central , vol. 7, BioMed Central , 2013, doi:10.1186/1753-6561-7-s6-p9.
ELSA
| DOI
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2013 | Konferenzband - Beitrag | ELSA-ID: 2818 |

Kern, Simon, et al. “Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes.” BMC Proceedings / BioMed Central , vol. 7, BioMed Central, 2013, doi:10.1186/1753-6561-7-s6-p11.
ELSA
| DOI
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2013 | Sammelwerk - Beitrag | ELSA-ID: 10214
Frahm, Björn. “Seed Train Optimization for Cell Culture.” Animal Cell Biotechnology - Methods and Protocols, edited by Ralf Pörtner, 3rd ed., vol. 1104, Humana Press, 2013, pp. 355–67, https://doi.org/10.1007/978-1-62703-733-4_22.
ELSA
| DOI
2013 | Konferenz - Poster | ELSA-ID: 2980
Kern, S., et al. Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse. 2013.
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2981
Kern, S., et al. Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes. 2013.
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne, T., et al. Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags. 2013.
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, Tanja, et al. Seed Train Optimization for Suspension Cell Culture. 2013.
ELSA
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 |

Frahm, Björn, and H. Brod. “Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA).” Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009, vol. 5, Springer, 2012, pp. 355–59, doi:10.1007/978-94-007-0884-6_56.
ELSA
| DOI
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2012 | Patent | ELSA-ID: 2877
Brod, Helmut, and Björn Frahm. Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen. 2012.
ELSA
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke, W., et al. “Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor.” Achema 2012, Vogel Business Media, 2012.
ELSA
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui, R., et al. Optimierung des Seed trains von Suspensions-Zellkulturen. 2012.
ELSA
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke, Wouter, et al. “A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor.” Journal of Molecular Catalysis B: Enzymatic, vol. 68, no. 2, Elsevier, 2011, pp. 154–61, doi:10.1016/j.molcatb.2010.10.004.
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2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke, W., et al. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. 2011.
ELSA
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks, B., et al. “Intensified Absorption and Distillation Devices for Modular Chemical Production Processes.” Proceedings 19th International Congress of Chemical and Process Engineering, Czech Society of Chemical Engineering, 2010.
ELSA
2010 | Patent | ELSA-ID: 2873
Brod, Helmut, et al. Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen. 2010.
ELSA
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm, Björn, and Helmut Brod. Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration. 2010.
ELSA
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks, B., et al. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. 2010.
ELSA
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 |

Frahm, Björn, et al. “Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration.” Cytotechnology, vol. 59, no. 1, Springer, 2009, pp. 17–30, doi:10.1007/s10616-009-9189-9.
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2009 | Patent | ELSA-ID: 2872
Braun, Arndt, et al. Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen. 2009.
ELSA
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm, Björn, et al. Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA). 2009.
ELSA
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm, Björn, et al. Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA). 2009.
ELSA
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke, W., et al. Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor. 2009.
ELSA
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod, H., et al. Pushing the Limits in High-Density Mammalian Cell Fermentation. 2008.
ELSA
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm, Björn, et al. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). 2008.
ELSA
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm, Björn, and Helmut Brod. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). 2008.
ELSA
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm, Björn, et al. “Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien.” Chemie Ingenieur Technik, vol. 79, no. 7, WILEY-VCH Verlag, 2007, pp. 1052–58, doi:10.1002/cite.200700070.
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2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Pörtner, Ralf, et al. “Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller.” Cell Technology for Cell Products, vol. 3, Springer, 2007, pp. 497–501, doi:10.1007/978-1-4020-5476-1_84.
ELSA
| DOI
2007 | Patent | ELSA-ID: 2870 |

Brod, Helmut, et al. Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component. 2007.
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2007 | Patent | ELSA-ID: 2871
Brod, Helmut, et al. Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen. 2007.
ELSA
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod, Helmut, et al. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. 2007.
ELSA
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod, Helmut, et al. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. 2007.
ELSA
2007 | Konferenz - Poster | ELSA-ID: 2967
Frahm, Björn, et al. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). 2007.
ELSA
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 |

Frahm, Björn, et al. “Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode.” Chemie Ingenieur Technik, vol. 77, no. 4, WILEY-VCH Verlag, 2005, pp. 429–35, doi:10.1002/cite.200407094.
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2005 | Konferenzband - Beitrag | ELSA-ID: 2813
Frahm, Björn, and R. Pörtner. “Flexible Fed-Batch Process Control of Animal Cells.” Animal Cell Technology Meets Genomics, vol. 2, Springer, 2005, pp. 693–95, doi:10.1007/1-4020-3103-3_142.
ELSA
| DOI
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Pörtner, Ralf, et al. Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive OLFO-Controller. 2005.
ELSA
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Pörtner, R., et al. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. 2005.
ELSA
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 |

Pörtner, Ralf, et al. “Evaluation of Selected Control Strategies for Fed-Batch Cultures of a Hybridoma Cell Line.” Biotechnology and Applied Biochemistry, vol. 40, 47, Wiley-Blackwell, 2004, doi:10.1042/ba20030168.
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2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 |

Frahm, Björn, et al. “Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung.” Chemie Ingenieur Technik, vol. 75, no. 4, WILEY-VCH Verlag, 2003, pp. 457–60, doi:10.1002/cite.200390093.
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2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 |

Frahm, Björn, et al. “Improvement of a Mammalian Cell Culture Process by Adaptive, Model-Based Dialysis Fed-Batch Cultivation and Suppression of Apoptosis.” Bioprocess and Biosystems Engineering, vol. 26, no. 1, Springer, 2003, pp. 1–10, doi:10.1007/s00449-003-0335-z.
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2003 | Dissertation | ELSA-ID: 2393
Frahm, Björn. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Books on Demand GmbH, 2003.
ELSA
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Frahm, Björn, et al. “Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control.” Technische Systeme Für Biotechnologie Und Umwelt, edited by Dieter Beckmann and Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld), Inst. für Bioprozess- und Analysenmesstechnik , 2003, pp. 503–09.
ELSA
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Kühn, K., et al. “Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells.” ECCE - 4th European Congress of Chemical Engineering, edited by European Federation of Chemical Engineering, vol. 10, ECCE4, 2003.
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Frahm, Björn, and Ralf Pörtner. Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung. 2003.
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Hass, V. C., et al. Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung. 2003.
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Frahm, Björn, et al. Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies. 2003.
ELSA
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2003 | Konferenz - Vortrag | ELSA-ID: 2906
Pörtner, Ralf, et al. Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung. 2003.
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2964
Frahm, Björn, and Ralf Pörtner. CO2-off-Gas Measurement for Animal Cell Culture Processes. 2003.
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2965
Frahm, Björn, and Ralf Pörtner. Flexible Fed-Batch Process Control of Animal Cells. 2003.
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2966
Kühn, K., et al. Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. 2003.
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Frahm, Björn, and Ralf Pörtner. Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies. 2003.
ELSA
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 |

Frahm, Björn, et al. “Determination of Dissolved CO2 Concentration and CO2 Production Rate of Mammalian Cell Suspension Culture Based on Off-Gas Measurement.” Journal of Biotechnology, vol. 99, no. 2, Elsevier, 2002, pp. 133–48, doi:https://doi.org/10.1016/S0168-1656(02)00180-3.
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2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 |

Frahm, Björn, et al. “Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells.” Biotechnology Progress, vol. 18, no. 5, Wiley , 2002, pp. 1095–103, doi:10.1021/bp020035y.
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2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Frahm, Björn, and R. Pörtner. “Reaktor-Abgasmessungen bei Zellkulturen.” BIOforum, vol. 4, GIT-Verlag, 2002, pp. 179–80.
ELSA
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Frahm, Björn, and Ralf Pörtner. “Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen.” Biosystemtechnik: Innovative Biosystemtechnik - Sensorik, Aktorik Und Auswertung Biotechnologischer Prozesse, edited by Heiner Kaden and Forum Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung Biotechnologischer Prozesse (2001 : Waldheim), Kurt-Schwabe-Inst. , 2002, pp. 39–48.
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Frahm, Björn, and Ralf Pörtner. Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. 2002.
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Frahm, Björn, and Ralf Pörtner. Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells. 2002.
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Frahm, Björn, and Ralf Pörtner. Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells. 2002.
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Frahm, Björn, et al. Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control. 2002.
ELSA
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
Frahm, Björn, et al. “Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells.” Animal Cell Technology: From Target to Market, vol. 1, Springer, 2001, pp. 446–48, doi:10.1007/978-94-010-0369-8_107.
ELSA
| DOI
2001 | Konferenz - Poster | ELSA-ID: 2429
Hass, V. C., et al. Model-Based Control of Hybridoma Cell Cultures. 2001.
ELSA
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Hoffmann, M., et al. Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen. 2001.
ELSA
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Frahm, Björn, and R. Pörtner. Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik. 2001.
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2960
Frahm, Björn, et al. Adaptive Modellgestützte Steuerung von Zellkulturprozessen. 2001.
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2961
Lane, P., et al. Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities. 2001.
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2962
Frahm, Björn, et al. Development of an Automated, Model-Based, Adaptive Control for the Effective Cultivation of Hybridoma Cells. 2001.
ELSA
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 |

Hass, V. C., et al. “Model-Based Control of Hybridoma Cell Cultures.” Computer Applications in Biotechnology, 2001: Modelling, Monitoring and Control of Biotechnological Processes, edited by Published for the International Federation of Automatic Control by Pergamon , vol. 34, ScienceDirect, 2001, pp. 323–29, doi:https://doi.org/10.1016/S1474-6670(17)34240-4.
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2001 | Konferenz - Vortrag | ELSA-ID: 7933
Frahm, Björn, and Ralf Pörtner. Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen. 2001.
ELSA
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Anderelei, T., et al. Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren. 2000.
ELSA
2000 | Konferenz - Poster | ELSA-ID: 2959
Hoffmann, M., et al. Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. 2000.
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168 Publikationen
2024 | Konferenz - Vortrag | ELSA-ID: 12021
Segermann, Jan, et al. Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie. 2024.
ELSA
2024 | Konferenz - Vortrag | ELSA-ID: 12022
Luttmann, Mario, et al. Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen. 2024.
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2024 | Konferenz - Poster | ELSA-ID: 12395
Müller, Carolin, et al. Investigation of Microbial Spoilage in Vegan Foods. 2024.
ELSA
2024 | Konferenz - Poster | ELSA-ID: 12396
Gassenmeier, Veronika, et al. Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-Situ Monitoring of Hybridoma Cell Culture. 2024.
ELSA
2024 | Konferenz - Poster | ELSA-ID: 12397
Blome, André, et al. Process Optimization in Baked Goods Production Using Inline Sensors and Objective Product Evaluation. 2024.
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2024 | Preprint | ELSA-ID: 12400 |

Ramm, Selina, et al. Semi-Automated vs. Manual: Comparative Study of Cell Culture Counting Methods Using Validation Parameters. bioRxiv, 2024, https://doi.org/10.1101/2024.05.30.596619.
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2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Kosse, Pascal, et al. “Comparative Analysis of PH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator.” Chemie Ingenieur Technik, vol. 96, no. 4, 2024, pp. 528–34, https://doi.org/10.1002/cite.202300188.
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2024 | Konferenz - Poster | ELSA-ID: 10957
Reinhardt, Lena, et al. Mycelium-Based Materials from Residues of the Regional Wood Industry.
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2023 | Konferenz - Poster | ELSA-ID: 12483
Blome, André, et al. Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. 2023.
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2023 | Konferenz - Poster | ELSA-ID: 12485
Luttmann, Mario, et al. Teig 4.0 - Promotionsthemen. 2023.
ELSA
2023 | Konferenz - Vortrag | ELSA-ID: 11109
Blome, André, et al. Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung. 2023.
ELSA
2023 | Konferenz - Poster | ELSA-ID: 11110
Blome, André, et al. Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung. 2023.
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2023 | Konferenz - Poster | ELSA-ID: 11378
Gassenmeier, Veronika, et al. Real-Time Monitoring of DCO2 in Addition to DO.
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2023 | Konferenz - Poster | ELSA-ID: 11381
Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. DECHEMA e.V.
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2023 | Konferenz - Poster | ELSA-ID: 11382 |

Gassenmeier, Veronika, et al. View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks.
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2023 | Konferenz - Vortrag | ELSA-ID: 11383
Hernández Rodriguez, Tanja, et al. Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture. DECHEMA e.V., 2023.
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2023 | Konferenzband - Beitrag | ELSA-ID: 11384 |

Müller, Carolin, et al. “Microbial Spoilage in Vegan Foods.” Proceedings of the 10th International Congress of Food Technologists, Biotechnologists and Nutritionists: Smart Food for a Healthy Planet and Human Prosperity, Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023, pp. 64–67.
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2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Kosse, Pascal, et al. “Validation and Uncertainty Assessment of a Software‐Integrated Workflow for PH Calculations.” Chemie Ingenieur Technik, vol. 95, no. 12, 2023, pp. 1960–69, https://doi.org/10.1002/cite.202300082.
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2023 | Konferenz - Poster | ELSA-ID: 11487 |

Ramm, Selina, et al. Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression . DECHEMA e.V.
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2023 | Konferenz - Poster | ELSA-ID: 10201 |

Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development. 2023.
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2023 | Konferenzband - Beitrag | ELSA-ID: 10788 |

Ramm, Selina, et al. “Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities.” 2023 IEEE 21st International Conference on Industrial Informatics (INDIN), edited by Jürgen Jasperneite et al., IEEE, 2023, pp. 1–6, https://doi.org/10.1109/INDIN51400.2023.10218012.
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2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Processes, vol. 10, no. 5, 883, 2022, https://doi.org/10.3390/pr10050883.
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2022 | Datenpublikation | ELSA-ID: 10190
Gassenmeier, Veronika, and Björn Frahm. Real-Time Monitoring of DCO2 in Addition to DO. assets-labs, 2022.
ELSA
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2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Hernández Rodriguez, Tanja, et al. “Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design.” Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, edited by Ralf Pörtner and Johannes Möller, vol. special issue, MDPI, 2022, pp. 21–48, https://doi.org/10.3390/pr10050883.
ELSA
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2022 | Konferenzband - Beitrag | ELSA-ID: 10195
Blome, André, et al. “Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products.” Proceedings of the 33rd VH Yeast Conference 2022: Advances in Applied Research & Industrial Production of Baker’s Yeast, “100th Anniversary of VH Berlin & Yeast(s) as an Alternative Protein Source,” Versuchsanstalt der Hefeindustrie e.V., 2022, pp. 61–66.
ELSA
2022 | Konferenz - Vortrag | ELSA-ID: 10196
Blome, André, et al. Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products. 2022.
ELSA
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Hernández Rodriguez, Tanja, et al. “Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture.” ACHEMA 2022, 2022.
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10198
Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion.
ELSA
2022 | Konferenz - Poster | ELSA-ID: 10199 |

Müller, Carolin, et al. “Microbial Spoilage in Vegan Foods.” PBN 2022 Congress, 2022.
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2022 | Konferenz - Poster | ELSA-ID: 7932
Hernández Rodriguez, Tanja, et al. A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development.
ELSA
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Gassenmeier, Veronika, et al. “Model-Assisted DoE Applied to Microalgae Processes, Current Research in Biotechnology.” Current Research in Biotechnology, vol. 4, 2022, pp. 102–19, https://doi.org/10.1016/j.crbiot.2022.01.005.
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2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
Kuhfuß, Fabian, et al. “View on a Mechanistic Model of Chlorella Vulgaris in Incubated Shake Flasks.” Bioprocess and Biosystems Engineering, vol. 45, 2022, pp. 15–30, https://doi.org/10.1007/s00449-021-02627-2.
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study.” Processes, vol. 9, no. 6, 964, 2021, https://doi.org/10.3390/pr9060964.
ELSA
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2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Hernández Rodriguez, Tanja, and Björn Frahm. “Digital Seed Train Twins and Statistical Methods.” Digital Twins Tools and Concepts for Smart Biomanufacturing, edited by Christoph Herwig et al., vol. 176, Springer, 2021, pp. 97–131, https://doi.org/10.1007/10_2020_137.
ELSA
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2021 | Konferenz - Vortrag | ELSA-ID: 7927
Hernández Rodriguez, Tanja, and Björn Frahm. Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction. 2021.
ELSA
2021 | Konferenz - Poster | ELSA-ID: 7931
Moser, André, et al. Model-Assisted Design of Experiments - Concept, Software and Applications. 2021.
ELSA
2021 | Lexikoneintrag | ELSA-ID: 7939
Wirtanen, Gun, et al. “Bovine Colostrum for Human Consumption.” MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021.
ELSA
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
Fasse, Sylvia, et al. “Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing.” Dairy, vol. 2, no. 4, 2021, pp. 556–75, https://doi.org/10.3390/dairy2040044.
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| WoS
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Hernández Rodriguez, Tanja, et al. “Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection – a Simulation Study.” Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, vol. special issue, MDPI, 2021, pp. 49–74, https://doi.org/10.3390/pr9060964.
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Hernández Rodriguez, Tanja, et al. “Dynamic Parameter Estimation and Prediction over Consecutive Scales, Based on Moving Horizon Estimation - Applied to an Industrial Cell Culture Seed Train.” Bioprocess and Biosystems Engineering, vol. 44, no. 4, 2021, pp. 793–808, https://doi.org/10.1007/s00449-020-02488-1 .
ELSA
| DOI
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Moser, André, et al. “Model-Assisted DoE Software: Optimization of Growth and Biocatalysis in Saccharomyces Cerevisiae Bioprocesses.” Bioprocess and Biosystems Engineering, vol. 44, no. 4, 2021, pp. 683–700, https://doi.org/10.1007/s00449-020-02478-3.
ELSA
| DOI
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Blome, André, et al. “Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung.” Seminar Life Science Technologies 2021-04-28, 2021.
ELSA
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
Möller, Johannes, et al. “Model Uncertainty-Based Evaluation of Process Strategies during Scale-up of Biopharmaceutical Processes.” Computers & Chemical Engineering, vol. 134, Elsevier, 2020, pp. 1–13, doi:10.1016/j.compchemeng.2019.106693.
ELSA
| DOI
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Hernández Rodríguez, Tanja, and Björn Frahm. “Design, Optimization and Adaptive Control of Cell Culture Seed Trains.” Animal Cell Biotechnology - Methods and Protocols, edited by Ralf Pörtner, vol. 2095, Springer, 2020, pp. 251–67, doi:10.1007/978-1-0716-0191-4_14.
ELSA
| DOI
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
Deppe, S., et al. “Estimation of Process Model Parameters.” Animal Cell Biotechnology: Methods and Protocols, edited by Ralf Pörtner, vol. 2095, Springer, 2020, pp. 213–34, doi:10.1007/978-1-0716-0191-4_12.
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Hernández Rodriguez, Tanja, et al. “Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach.” BMC Proceedings, vol. 14, BioMed Central, 2020, p. P408, doi:10.1186/s12919-020-00188-y.
ELSA
| Dateien verfügbar
| DOI
2020 | Konferenz - Poster | ELSA-ID: 3007
Kuhfuß, F., et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3008
Deppe, S., et al. Model-Assisted Design of Experiments for Algae Cultivation. 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 3009
Ifrim, George Adrian, et al. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 7929
Hernández Rodriguez, Tanja, et al. Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration. 2020.
ELSA
2020 | Konferenz - Poster | ELSA-ID: 7930
Hernández Rodriguez, Tanja, et al. Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes. 2020.
ELSA
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Hernández Rodriguez, Tanja, et al. Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support. 2020.
ELSA
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Hernández Rodriguez, Tanja, et al. “Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration.” Chemie Ingenieur Technik, Tagungsband Zur 10. ProcessNet-Jahrestagung Und 34. DECHEMA-Jahrestagung Der Biotechnologen 2020, vol. No. 9, Wiley, 2020, pp. 1225 – 1226, doi:10.1002/cite.202055235.
ELSA
| DOI
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Hernández Rodriguez, Tanja, et al. “Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes.” Chemie Ingenieur Technik, Tagungsband Zur 10. ProcessNet-Jahrestagung Und 34. DECHEMA-Jahrestagung Der Biotechnologen 2020, vol. No. 9, Wiley, 2020, pp. 1241 – 1242, doi:10.1002/cite.202055234.
ELSA
| DOI
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 |

Hernández Rodriguez, Tanja, et al. “Predicting Industrial‐scale Cell Culture Seed Trains–A Bayesian Framework for Model Fitting and Parameter Estimation, Dealing with Uncertainty in Measurements and Model Parameters, Applied to a Nonlinear Kinetic Cell Culture Model, Using an MCMC Method.” Biotechnology and Bioengineering, vol. 116, no. 11, Wiley, 2019, pp. 2944–59, doi:10.1002/bit.27125.
ELSA
| DOI
| Download (ext.)
2019 | Konferenzband - Beitrag | ELSA-ID: 2400
Ifrim, George Adrian, et al. “Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae.” 2019 23rd International Conference on System Theory, Control and Computing (ICSTCC), IEEE, 2019, doi:10.1109/icstcc.2019.8886109.
ELSA
| DOI
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Möller, J., et al. Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes. 2019.
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Möller, J., et al. Model-Assisted Design of Experiments. 2019.
ELSA
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Ifrim, George Adrian, et al. Novel Control Strategy for Microalgae in Photobioreactor. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3000
Hernández Rodriguez, Tanja, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3001
Hernández Rodriguez, Tanja, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3002
Möller, J., et al. Model-Assisted Design of Experiments – Software Toolbox. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3003
Deppe, S., et al. Model-Assisted Design of Experiments for Algae Cultivation. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3004
Ifrim, George Adrian, et al. Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3005
Hernández Rodriguez, Tanja, et al. Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating. 2019.
ELSA
2019 | Konferenz - Poster | ELSA-ID: 3006
Ifrim, George Adrian, et al. Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae. 2019.
ELSA
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 |

Möller, J., et al. “Model-Assisted Design of Process Strategies for Cell Culture Processes.” American Pharmaceutical Review, vol. 3, Russel, 2018, pp. 39–41.
ELSA
| Download (ext.)
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Hernández Rodriguez, Tanja, et al. “Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization.” BMC Proceedings, vol. 112, BioMed Central, 2018, p. P175, doi:10.1186/s12919-018-0097-x.
ELSA
| Dateien verfügbar
| DOI
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Pörtner, R., et al. Model-Assisted Design of Process Strategies for Cell Culture Processes. 2018.
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2997
Möller, J., et al. Model-Assisted Design and Optimization of Process Strategies. 2018.
ELSA
2018 | Konferenz - Poster | ELSA-ID: 2999
Hernández Rodriguez, Tanja, et al. Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses. 2018.
ELSA
2018 | Konferenz - Vortrag | ELSA-ID: 7935
Hernández Rodriguez, Tanja, et al. A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization. 2018.
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Hernández Rodriguez, Tanja, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017.
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Pörtner, R., et al. Model-Assisted Design and Optimization of Biotechnological Processes. 2017.
ELSA
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Hernández Rodriguez, Tanja, et al. Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren. 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2994
Hernández Rodriguez, Tanja, et al. Influence of Parameter Accuracies in Cell Culture Seed Train Simulations. 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2995
Hernández Rodriguez, Tanja, et al. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. 2017.
ELSA
2017 | Konferenz - Poster | ELSA-ID: 2996
Hernández Rodriguez, Tanja, et al. Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization. 2017.
ELSA
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
Pörtner, R., et al. “Advanced Process and Control Strategies for Bioreactors.” Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls, Elsevier, 2016, pp. 463–93, doi:10.1016/b978-0-444-63663-8.00016-1.
ELSA
| DOI
2016 | Konferenz - Poster | ELSA-ID: 2991
Beshay, U., et al. DMA Photobioreactor System – Cultivation at Low Shear Stress and Optional Membrane Aeration. 2016.
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2992
Hernández Rodriguez, Tanja, et al. A Software Tool for Biopharmaceutical Seed Train Design and Optimization. 2016.
ELSA
2016 | Konferenz - Poster | ELSA-ID: 2993
Koopmann, K. S., et al. Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies. 2016.
ELSA
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Kern, Simon, et al. “Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale.” Cytotechnology, vol. 68, no. 4, Springer, 2015, pp. 1019–32, doi:10.1007/s10616-015-9858-9.
ELSA
| DOI
| Download (ext.)
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 |

Hernández Rodriguez, Tanja, et al. “Considerations for Cell Passaging in Cell Culture Seed Trains.” BMC Proceedings / BioMed Central, vol. 9, BioMed Central, 2015, doi:10.1186/1753-6561-9-s9-p43.
ELSA
| DOI
| Download (ext.)
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 |

Kern, Simon, et al. “Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale.” BMC Proceedings / BioMed Central, vol. 9, BioMed Central, 2015, doi:10.1186/1753-6561-9-s9-p44.
ELSA
| DOI
| Download (ext.)
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Frahm, Björn, et al. Seed Train Design and Optimization for Animal Cell Suspension Culture. 2015.
ELSA
| Dateien verfügbar
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Frahm, Björn, et al. Seed Train Design and Optimization for Animal Cell Suspension Culture. 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2985
Hernández Rodriguez, Tanja, et al. Considerations for Cell Passaging in Cell Culture Seed Trains. 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2986
Kern, S., et al. Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2987
Hernández Rodriguez, Tanja, et al. A Software Tool for Biopharmaceutical Seed Train Design and Optimization. 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2988
Hernández Rodriguez, Tanja, et al. Considerations for Cell Passaging in Cell Culture Seed Trains. 2015.
ELSA
2015 | Konferenz - Poster | ELSA-ID: 2990
Kern, S., et al. Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale. 2015.
ELSA
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Hahne, T., et al. “Disposable Algae Cultivation for High-Value Products Using All around LED-Illumination Directly on the Bags.” Journal of Algal Biomass Utilization, vol. 5, no. 2, PHYCO SPECTRUM, 2014, pp. 66–73.
ELSA
2014 | Patent | ELSA-ID: 2878
Frahm, Björn, and Uwe Meier. Beleuchtung von Disposable Bioreaktoren. 2014.
ELSA
2014 | Konferenz - Poster | ELSA-ID: 2984
Drews, F., et al. Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche. 2014.
ELSA
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 |

Hernández Rodriguez, Tanja, et al. “Seed Train Optimization for Suspension Cell Culture.” BMC Proceedings / BioMed Central , vol. 7, BioMed Central , 2013, doi:10.1186/1753-6561-7-s6-p9.
ELSA
| DOI
| Download (ext.)
2013 | Konferenzband - Beitrag | ELSA-ID: 2818 |

Kern, Simon, et al. “Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes.” BMC Proceedings / BioMed Central , vol. 7, BioMed Central, 2013, doi:10.1186/1753-6561-7-s6-p11.
ELSA
| DOI
| Download (ext.)
2013 | Sammelwerk - Beitrag | ELSA-ID: 10214
Frahm, Björn. “Seed Train Optimization for Cell Culture.” Animal Cell Biotechnology - Methods and Protocols, edited by Ralf Pörtner, 3rd ed., vol. 1104, Humana Press, 2013, pp. 355–67, https://doi.org/10.1007/978-1-62703-733-4_22.
ELSA
| DOI
2013 | Konferenz - Poster | ELSA-ID: 2980
Kern, S., et al. Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse. 2013.
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2981
Kern, S., et al. Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes. 2013.
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2982
Hahne, T., et al. Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags. 2013.
ELSA
2013 | Konferenz - Poster | ELSA-ID: 2983
Hernández Rodriguez, Tanja, et al. Seed Train Optimization for Suspension Cell Culture. 2013.
ELSA
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 |

Frahm, Björn, and H. Brod. “Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA).” Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009, vol. 5, Springer, 2012, pp. 355–59, doi:10.1007/978-94-007-0884-6_56.
ELSA
| DOI
| Download (ext.)
2012 | Patent | ELSA-ID: 2877
Brod, Helmut, and Björn Frahm. Photobioreaktor Mit Rotatorisch Oszillierenden Lichtquellen. 2012.
ELSA
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Van Hecke, W., et al. “Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor.” Achema 2012, Vogel Business Media, 2012.
ELSA
2012 | Konferenz - Poster | ELSA-ID: 2973
Marzougui, R., et al. Optimierung des Seed trains von Suspensions-Zellkulturen. 2012.
ELSA
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
Van Hecke, Wouter, et al. “A Biocatalytic Cascade Reaction Sensitive to the Gas–Liquid Interface: Modeling and Upscaling in a Dynamic Membrane Aeration Reactor.” Journal of Molecular Catalysis B: Enzymatic, vol. 68, no. 2, Elsevier, 2011, pp. 154–61, doi:10.1016/j.molcatb.2010.10.004.
ELSA
| DOI
| Download (ext.)
2011 | Konferenz - Poster | ELSA-ID: 2972
Van Hecke, W., et al. Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor. 2011.
ELSA
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Dercks, B., et al. “Intensified Absorption and Distillation Devices for Modular Chemical Production Processes.” Proceedings 19th International Congress of Chemical and Process Engineering, Czech Society of Chemical Engineering, 2010.
ELSA
2010 | Patent | ELSA-ID: 2873
Brod, Helmut, et al. Verfahren Zur Reduzierung von Ablagerungen Bei Der Kultivierung von Organismen. 2010.
ELSA
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Frahm, Björn, and Helmut Brod. Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration. 2010.
ELSA
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Dercks, B., et al. Intensified Absorption and Distillation Devices for Modular Chemical Production Processes. 2010.
ELSA
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 |

Frahm, Björn, et al. “Improving Bioreactor Cultivation Conditions for Sensitive Cell Lines by Dynamic Membrane Aeration.” Cytotechnology, vol. 59, no. 1, Springer, 2009, pp. 17–30, doi:10.1007/s10616-009-9189-9.
ELSA
| DOI
| Download (ext.)
2009 | Patent | ELSA-ID: 2872
Braun, Arndt, et al. Verfahren Und Vorrichtung Zur Rückhaltung Und Rückführung von Zellen. 2009.
ELSA
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Frahm, Björn, et al. Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA). 2009.
ELSA
2009 | Konferenz - Poster | ELSA-ID: 2970
Frahm, Björn, et al. Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA). 2009.
ELSA
2009 | Konferenz - Poster | ELSA-ID: 2971
Van Hecke, W., et al. Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor. 2009.
ELSA
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Brod, H., et al. Pushing the Limits in High-Density Mammalian Cell Fermentation. 2008.
ELSA
2008 | Konferenz - Poster | ELSA-ID: 2968
Frahm, Björn, et al. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). 2008.
ELSA
2008 | Konferenz - Poster | ELSA-ID: 2969
Frahm, Björn, and Helmut Brod. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). 2008.
ELSA
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Frahm, Björn, et al. “Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien.” Chemie Ingenieur Technik, vol. 79, no. 7, WILEY-VCH Verlag, 2007, pp. 1052–58, doi:10.1002/cite.200700070.
ELSA
| DOI
| Download (ext.)
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Pörtner, Ralf, et al. “Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller.” Cell Technology for Cell Products, vol. 3, Springer, 2007, pp. 497–501, doi:10.1007/978-1-4020-5476-1_84.
ELSA
| DOI
2007 | Patent | ELSA-ID: 2870 |

Brod, Helmut, et al. Procedure for Gassing of Liquid for Cell Cultures, Comprises Exchanging of Gas over Immersed Membrane Surfaces and Controlling the Gassing Rate Change of the Gas Concentration and/or Pressure of the Gas or Gas Mixture or Gas Component. 2007.
ELSA
| Download (ext.)
2007 | Patent | ELSA-ID: 2871
Brod, Helmut, et al. Verfahren Und Vorrichtung Zur Be- Und Entgasung von Flüssigkeiten, Insbesondere in Der Biotechnologie Und Speziell von Zellkulturen. 2007.
ELSA
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Brod, Helmut, et al. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. 2007.
ELSA
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Brod, Helmut, et al. Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen. 2007.
ELSA
2007 | Konferenz - Poster | ELSA-ID: 2967
Frahm, Björn, et al. High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA). 2007.
ELSA
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 |

Frahm, Björn, et al. “Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode.” Chemie Ingenieur Technik, vol. 77, no. 4, WILEY-VCH Verlag, 2005, pp. 429–35, doi:10.1002/cite.200407094.
ELSA
| DOI
| Download (ext.)
2005 | Konferenzband - Beitrag | ELSA-ID: 2813
Frahm, Björn, and R. Pörtner. “Flexible Fed-Batch Process Control of Animal Cells.” Animal Cell Technology Meets Genomics, vol. 2, Springer, 2005, pp. 693–95, doi:10.1007/1-4020-3103-3_142.
ELSA
| DOI
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Pörtner, Ralf, et al. Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive OLFO-Controller. 2005.
ELSA
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Pörtner, R., et al. Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode. 2005.
ELSA
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 |

Pörtner, Ralf, et al. “Evaluation of Selected Control Strategies for Fed-Batch Cultures of a Hybridoma Cell Line.” Biotechnology and Applied Biochemistry, vol. 40, 47, Wiley-Blackwell, 2004, doi:10.1042/ba20030168.
ELSA
| DOI
| Download (ext.)
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 |

Frahm, Björn, et al. “Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung.” Chemie Ingenieur Technik, vol. 75, no. 4, WILEY-VCH Verlag, 2003, pp. 457–60, doi:10.1002/cite.200390093.
ELSA
| DOI
| Download (ext.)
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 |

Frahm, Björn, et al. “Improvement of a Mammalian Cell Culture Process by Adaptive, Model-Based Dialysis Fed-Batch Cultivation and Suppression of Apoptosis.” Bioprocess and Biosystems Engineering, vol. 26, no. 1, Springer, 2003, pp. 1–10, doi:10.1007/s00449-003-0335-z.
ELSA
| DOI
| Download (ext.)
2003 | Dissertation | ELSA-ID: 2393
Frahm, Björn. Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen. Books on Demand GmbH, 2003.
ELSA
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Frahm, Björn, et al. “Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control.” Technische Systeme Für Biotechnologie Und Umwelt, edited by Dieter Beckmann and Heiligenstädter Kolloquium (11 : 2002 : Heiligenstadt, Eichsfeld), Inst. für Bioprozess- und Analysenmesstechnik , 2003, pp. 503–09.
ELSA
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Kühn, K., et al. “Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells.” ECCE - 4th European Congress of Chemical Engineering, edited by European Federation of Chemical Engineering, vol. 10, ECCE4, 2003.
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Frahm, Björn, and Ralf Pörtner. Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung. 2003.
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Hass, V. C., et al. Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung. 2003.
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Frahm, Björn, et al. Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies. 2003.
ELSA
| Dateien verfügbar
2003 | Konferenz - Vortrag | ELSA-ID: 2906
Pörtner, Ralf, et al. Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung. 2003.
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2964
Frahm, Björn, and Ralf Pörtner. CO2-off-Gas Measurement for Animal Cell Culture Processes. 2003.
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2965
Frahm, Björn, and Ralf Pörtner. Flexible Fed-Batch Process Control of Animal Cells. 2003.
ELSA
2003 | Konferenz - Poster | ELSA-ID: 2966
Kühn, K., et al. Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells. 2003.
ELSA
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Frahm, Björn, and Ralf Pörtner. Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies. 2003.
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2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 |

Frahm, Björn, et al. “Determination of Dissolved CO2 Concentration and CO2 Production Rate of Mammalian Cell Suspension Culture Based on Off-Gas Measurement.” Journal of Biotechnology, vol. 99, no. 2, Elsevier, 2002, pp. 133–48, doi:https://doi.org/10.1016/S0168-1656(02)00180-3.
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2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 |

Frahm, Björn, et al. “Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells.” Biotechnology Progress, vol. 18, no. 5, Wiley , 2002, pp. 1095–103, doi:10.1021/bp020035y.
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2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Frahm, Björn, and R. Pörtner. “Reaktor-Abgasmessungen bei Zellkulturen.” BIOforum, vol. 4, GIT-Verlag, 2002, pp. 179–80.
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2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Frahm, Björn, and Ralf Pörtner. “Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen.” Biosystemtechnik: Innovative Biosystemtechnik - Sensorik, Aktorik Und Auswertung Biotechnologischer Prozesse, edited by Heiner Kaden and Forum Innovative Biosystemtechnik - Sensorik, Aktorik und Auswertung Biotechnologischer Prozesse (2001 : Waldheim), Kurt-Schwabe-Inst. , 2002, pp. 39–48.
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Frahm, Björn, and Ralf Pörtner. Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen. 2002.
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Frahm, Björn, and Ralf Pörtner. Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells. 2002.
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Frahm, Björn, and Ralf Pörtner. Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells. 2002.
ELSA
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Frahm, Björn, et al. Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control. 2002.
ELSA
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
Frahm, Björn, et al. “Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells.” Animal Cell Technology: From Target to Market, vol. 1, Springer, 2001, pp. 446–48, doi:10.1007/978-94-010-0369-8_107.
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| DOI
2001 | Konferenz - Poster | ELSA-ID: 2429
Hass, V. C., et al. Model-Based Control of Hybridoma Cell Cultures. 2001.
ELSA
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Hoffmann, M., et al. Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen. 2001.
ELSA
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Frahm, Björn, and R. Pörtner. Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik. 2001.
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2960
Frahm, Björn, et al. Adaptive Modellgestützte Steuerung von Zellkulturprozessen. 2001.
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2001 | Konferenz - Poster | ELSA-ID: 2961
Lane, P., et al. Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities. 2001.
ELSA
2001 | Konferenz - Poster | ELSA-ID: 2962
Frahm, Björn, et al. Development of an Automated, Model-Based, Adaptive Control for the Effective Cultivation of Hybridoma Cells. 2001.
ELSA
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 |

Hass, V. C., et al. “Model-Based Control of Hybridoma Cell Cultures.” Computer Applications in Biotechnology, 2001: Modelling, Monitoring and Control of Biotechnological Processes, edited by Published for the International Federation of Automatic Control by Pergamon , vol. 34, ScienceDirect, 2001, pp. 323–29, doi:https://doi.org/10.1016/S1474-6670(17)34240-4.
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2001 | Konferenz - Vortrag | ELSA-ID: 7933
Frahm, Björn, and Ralf Pörtner. Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen. 2001.
ELSA
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Anderelei, T., et al. Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren. 2000.
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2000 | Konferenz - Poster | ELSA-ID: 2959
Hoffmann, M., et al. Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus. 2000.
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