Björn Frahm

Fachbereich 4 Life Science Technologies
bjoern.frahm@th-owl.de
ID
45666

168 Publikationen

Alle markieren

[168]
2024 | Konferenz - Vortrag | ELSA-ID: 12021
Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie
J. Segermann, M. Luttmann, A. Blome, S. Feldt, S. Sivanesan, C.-A. Holst, V. Lohweg, B. Frahm, U. Müller, Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie, 2024.
ELSA
 
[167]
2024 | Konferenz - Vortrag | ELSA-ID: 12022
Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen
M. Luttmann, A. Blome, J. Segermann, M. Jekle, B. Frahm, U. Müller, Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen, 2024.
ELSA
 
[166]
2024 | Konferenz - Poster | ELSA-ID: 12395
Investigation of microbial spoilage in vegan foods
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Investigation of Microbial Spoilage in Vegan Foods, 2024.
ELSA
 
[165]
2024 | Konferenz - Poster | ELSA-ID: 12396
Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-situ Monitoring of Hybridoma Cell Culture
V. Gassenmeier, G. Campolongo, B. Frahm, Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-Situ Monitoring of Hybridoma Cell Culture, 2024.
ELSA
 
[164]
2024 | Konferenz - Poster | ELSA-ID: 12397
Process optimization in baked goods production using inline sensors and objective product evaluation
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process Optimization in Baked Goods Production Using Inline Sensors and Objective Product Evaluation, 2024.
ELSA
 
[163]
2024 | Preprint | ELSA-ID: 12400 | OA
Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters
S. Ramm, U. Odefey, B. Frahm, M. Pein-Hackelbusch, (2024).
ELSA | DOI | Download (ext.)
 
[162]
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 96 (2024) 528–534.
ELSA | DOI | WoS
 
[161]
2024 | Konferenz - Poster | ELSA-ID: 10957
Mycelium-based materials from residues of the regional wood industry
L. Reinhardt, V. Gassenmeier, S. Feldt, S. Plate, M. Tremmel, B. Frahm, M. Stosch, Mycelium-Based Materials from Residues of the Regional Wood Industry, n.d.
ELSA
 
[160]
2023 | Konferenz - Poster | ELSA-ID: 12483
Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung, 2023.
ELSA
 
[159]
2023 | Konferenz - Poster | ELSA-ID: 12485
Teig 4.0 - Promotionsthemen
M. Luttmann, A. Blome, M. Jekle, B. Frahm, U. Müller, Teig 4.0 - Promotionsthemen, 2023.
ELSA
 
[158]
2023 | Konferenz - Vortrag | ELSA-ID: 11109
Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung
A. Blome, M. Luttmann, M. Jekle, B. Frahm, U. Müller, Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung, 2023.
ELSA
 
[157]
2023 | Konferenz - Poster | ELSA-ID: 11110
Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung, 2023.
ELSA
 
[156]
2023 | Konferenz - Poster | ELSA-ID: 11378
Real-time Monitoring of DCO2 in addition to DO
V. Gassenmeier, G. Campolongo, B. Frahm, Real-Time Monitoring of DCO2 in Addition to DO, n.d.
ELSA
 
[155]
2023 | Konferenz - Poster | ELSA-ID: 11381
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, DECHEMA e.V., n.d.
ELSA
 
[154]
2023 | Konferenz - Poster | ELSA-ID: 11382 | OA
View on a mechanistic model of Chlorella vulgaris in shake flasks
V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks, n.d.
ELSA | Download (ext.)
 
[153]
2023 | Konferenz - Vortrag | ELSA-ID: 11383
Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture
T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, DECHEMA e.V., 2023.
ELSA
 
[152]
2023 | Konferenzband - Beitrag | ELSA-ID: 11384 | OA
Microbial spoilage in vegan foods
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial Spoilage in Vegan Foods, Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023.
ELSA | Download (ext.)
 
[151]
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 95 (2023) 1960–1969.
ELSA | DOI | WoS
 
[150]
2023 | Konferenz - Poster | ELSA-ID: 11487 | OA
Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d.
ELSA | Download (ext.)
 
[149]
2023 | Konferenz - Poster | ELSA-ID: 10201 | OA
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, 2023.
ELSA | Download (ext.)
 
[148]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 | OA
Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.
ELSA | DOI | Download (ext.)
 
[147]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Processes 10 (2022).
ELSA | DOI
 
[146]
2022 | Datenpublikation | ELSA-ID: 10190
Real-time Monitoring of DCO2 in addition to DO
V. Gassenmeier, B. Frahm, Real-Time Monitoring of DCO2 in Addition to DO, assets-labs, 2022.
ELSA | Dateien verfügbar
 
[145]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022, pp. 21–48.
ELSA | DOI
 
[144]
2022 | Konferenzband - Beitrag | ELSA-ID: 10195
Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products, Versuchsanstalt der Hefeindustrie e.V., 2022.
ELSA
 
[143]
2022 | Konferenz - Vortrag | ELSA-ID: 10196
Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products, 2022.
ELSA
 
[142]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, 2022.
ELSA
 
[141]
2022 | Konferenz - Poster | ELSA-ID: 10198
A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion
T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion, n.d.
ELSA
 
[140]
2022 | Konferenz - Poster | ELSA-ID: 10199 | OA
Microbial spoilage in vegan foods
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial Spoilage in Vegan Foods, 2022.
ELSA | Download (ext.)
 
[139]
2022 | Konferenz - Poster | ELSA-ID: 7932
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, n.d.
ELSA
 
[138]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology
V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Current Research in Biotechnology 4 (2022) 102–119.
ELSA | DOI
 
[137]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
View on a mechanistic model of Chlorella vulgaris in incubated shake flasks
F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, Bioprocess and Biosystems Engineering 45 (2022) 15–30.
ELSA | DOI
 
[136]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Processes 9 (2021).
ELSA | DOI
 
[135]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Digital Seed Train Twins and Statistical Methods
T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021, pp. 97–131.
ELSA | DOI
 
[134]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction
T. Hernández Rodriguez, B. Frahm, Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction, 2021.
ELSA
 
[133]
2021 | Konferenz - Poster | ELSA-ID: 7931
Model-assisted Design of Experiments - Concept, Software and Applications
A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-Assisted Design of Experiments - Concept, Software and Applications, 2021.
ELSA
 
[132]
2021 | Lexikoneintrag | ELSA-ID: 7939
Bovine Colostrum for Human Consumption
G. Wirtanen, J. Alarinta, B. Frahm, S. Fasse, in: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021.
ELSA
 
[131]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing
S. Fasse, J. Alarinta, B. Frahm, G. Wirtanen, Dairy 2 (2021) 556–575.
ELSA | DOI | WoS
 
[130]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021, pp. 49–74.
ELSA | DOI
 
[129]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Bioprocess and Biosystems Engineering 44 (2021) 793–808.
ELSA | DOI
 
[128]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses
A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Bioprocess and Biosystems Engineering 44 (2021) 683–700.
ELSA | DOI
 
[127]
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung
A. Blome, M. Luttmann, B. Frahm, U. Müller, Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung, 2021.
ELSA
 
[126]
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes
J. Möller, T. Hernández Rodríguez, J. Müller, L. Arndt, K.B. Kuchemüller, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Computers & Chemical Engineering 134 (2020) 1–13.
ELSA | DOI
 
[125]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Design, Optimization and Adaptive Control of Cell Culture Seed Trains
T. Hernández Rodríguez, B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, Springer, Berlin, Heidelberg, New York, 2020, pp. 251–267.
ELSA | DOI
 
[124]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
Estimation of Process Model Parameters
S. Deppe, B. Frahm, V.C. Hass, T. Hernández Rodríguez, K.B. Kuchemüller, J. Möller, R. Pörtner, in: R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols, Springer, Berlin ; Heidelberg ; New York, 2020, pp. 213–234.
ELSA | DOI
 
[123]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, Claus Weihs, R. Pörtner, B. Frahm, Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, BioMed Central, 2020.
ELSA | Dateien verfügbar | DOI
 
[122]
2020 | Konferenz - Poster | ELSA-ID: 3007
Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration
F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, S. Deppe, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.
ELSA
 
[121]
2020 | Konferenz - Poster | ELSA-ID: 3008
Model-assisted Design of Experiments for algae cultivation
S. Deppe, F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, J. Möller, R. Pörtner, A. Moser, V.C. Hass, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2020.
ELSA
 
[120]
2020 | Konferenz - Poster | ELSA-ID: 3009
Modeling of microalgae in an air-lift photobioreactor for biomass production
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2020.
ELSA
 
[119]
2020 | Konferenz - Poster | ELSA-ID: 7929
Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.
ELSA
 
[118]
2020 | Konferenz - Poster | ELSA-ID: 7930
Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020.
ELSA
 
[117]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Integration of prior knowledge and digital tools for uncertainty-based decision support
T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support, 2020.
ELSA
 
[116]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration, Wiley, 2020.
ELSA | DOI
 
[115]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, Wiley, 2020.
ELSA | DOI
 
[114]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, C. Weihs, R. Pörtner, B. Frahm, Biotechnology and Bioengineering 116 (2019) 2944–2959.
ELSA | DOI | Download (ext.)
 
[113]
2019 | Konferenzband - Beitrag | ELSA-ID: 2400
Multivariable control strategy for the photosynthetic cultures of microalgae
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae, IEEE, 2019.
ELSA | DOI
 
[112]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Workflow for model-assisted design and scale-up of biopharmaceutical production processes
J. Möller, J. Müller, T. Hernández Rodriguez, K.B. Kuchemüller, L. Arndt, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes, 2019.
ELSA
 
[111]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Model-Assisted Design of Experiments
J. Möller, K.B. Kuchemüller, A. Moser, V.C. Hass, T. Hernández Rodriguez, S. Deppe, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments, 2019.
ELSA
 
[110]
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Novel control strategy for microalgae in photobioreactor
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Novel Control Strategy for Microalgae in Photobioreactor, 2019.
ELSA
 
[109]
2019 | Konferenz - Poster | ELSA-ID: 3000
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[108]
2019 | Konferenz - Poster | ELSA-ID: 3001
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[107]
2019 | Konferenz - Poster | ELSA-ID: 3002
Model-Assisted Design of Experiments – Software Toolbox
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, S. Deppe, G.A. Ifrim, A. Moser, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments – Software Toolbox, 2019.
ELSA
 
[106]
2019 | Konferenz - Poster | ELSA-ID: 3003
Model-assisted Design of Experiments for algae cultivation
S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K.B. Kuchemüller, R. Pörtner, A. Moser, V.C. Hass, G.A. Ifrim, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2019.
ELSA
 
[105]
2019 | Konferenz - Poster | ELSA-ID: 3004
Modeling of microalgae in an air-lift photobioreactor for biomass production
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2019.
ELSA
 
[104]
2019 | Konferenz - Poster | ELSA-ID: 3005
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[103]
2019 | Konferenz - Poster | ELSA-ID: 3006
Multivariable control strategy for the photosynthetic cultures of microalgae
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae, 2019.
ELSA
 
[102]
2019 | Konferenz - Vortrag | ELSA-ID: 7928
Scale-up of stirred vessels
B. Frahm, Scale-up of Stirred Vessels, 2019.
ELSA
 
[101]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
Model-Assisted Design of Process Strategies for Cell Culture Processes
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, American Pharmaceutical Review 3 (2018) 39–41.
ELSA | Download (ext.)
 
[100]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, BioMed Central, 2018.
ELSA | Dateien verfügbar | DOI
 
[99]
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Model-Assisted Design of Process Strategies for Cell Culture Processes
R. Pörtner, J. Möller, B. Frahm, V.C. Hass, Model-Assisted Design of Process Strategies for Cell Culture Processes, 2018.
ELSA
 
[98]
2018 | Konferenz - Poster | ELSA-ID: 2997
Model-Assisted Design and Optimization of Process Strategies
J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design and Optimization of Process Strategies, 2018.
ELSA
 
[97]
2018 | Konferenz - Poster | ELSA-ID: 2999
Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses
T. Hernández Rodriguez, J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018.
ELSA
 
[96]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization
T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, J. Stettner, A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization, 2018.
ELSA
 
[95]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren
T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[94]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Model-assisted design and optimization of biotechnological processes
R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, Model-Assisted Design and Optimization of Biotechnological Processes, 2017.
ELSA
 
[93]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren
T. Hernández Rodriguez, K.S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[92]
2017 | Konferenz - Poster | ELSA-ID: 2994
Influence of parameter accuracies in cell culture seed train simulations
T. Hernández Rodriguez, K.S. Koopmann, R. Pörtner, B. Frahm, Influence of Parameter Accuracies in Cell Culture Seed Train Simulations, 2017.
ELSA
 
[91]
2017 | Konferenz - Poster | ELSA-ID: 2995
Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017.
ELSA
 
[90]
2017 | Konferenz - Poster | ELSA-ID: 2996
Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017.
ELSA
 
[89]
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
Advanced Process and Control Strategies for Bioreactors
R. Pörtner, O. Platas Barradas, B. Frahm, V.C. Hass, in: Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls, Elsevier, Amsterdam, 2016, pp. 463–493.
ELSA | DOI
 
[88]
2016 | Konferenz - Poster | ELSA-ID: 2991
DMA Photobioreactor System – Cultivation at low shear stress and optional membrane aeration
U. Beshay, S. Feldt, B. Schwarze, P. Wefing, T. Hahne, J. Moschinski, C. Müller, R. Büker, M. Kramer, H. Brod, B. Frahm, DMA Photobioreactor System – Cultivation at Low Shear Stress and Optional Membrane Aeration, 2016.
ELSA
 
[87]
2016 | Konferenz - Poster | ELSA-ID: 2992
A software tool for biopharmaceutical seed train design and optimization
T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2016.
ELSA
 
[86]
2016 | Konferenz - Poster | ELSA-ID: 2993
Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies
K.S. Koopmann, T. Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, B. Frahm, Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies, 2016.
ELSA
 
[85]
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas-Barradas, R. Pörtner, B. Frahm, Cytotechnology 68 (2015) 1019–1032.
ELSA | DOI | Download (ext.)
 
[84]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[83]
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 | OA
Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas Barradas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[82]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Seed train design and optimization for animal cell suspension culture
B. Frahm, R. Pörtner, S. Kern, T. Hernández Rodriguez, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015.
ELSA | Dateien verfügbar
 
[81]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Seed train design and optimization for animal cell suspension culture
B. Frahm, T. Hernández Rodriguez, S. Kern, K.S. Koopmann, U. Beshay, O. Platas-Barradas, R. Pörtner, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015.
ELSA
 
[80]
2015 | Konferenz - Poster | ELSA-ID: 2985
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015.
ELSA
 
[79]
2015 | Konferenz - Poster | ELSA-ID: 2986
Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale, 2015.
ELSA
 
[78]
2015 | Konferenz - Poster | ELSA-ID: 2987
A software tool for biopharmaceutical seed train design and optimization
T. Hernández Rodriguez, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2015.
ELSA
 
[77]
2015 | Konferenz - Poster | ELSA-ID: 2988
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015.
ELSA
 
[76]
2015 | Konferenz - Poster | ELSA-ID: 2990
Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale, 2015.
ELSA
 
[75]
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags
T. Hahne, B. Schwarze, M. Kramer, B. Frahm, Journal of Algal Biomass Utilization 5 (2014) 66–73.
ELSA
 
[74]
2014 | Patent | ELSA-ID: 2878
Beleuchtung von disposable Bioreaktoren
B. Frahm, U. Meier, (2014).
ELSA
 
[73]
2014 | Konferenz - Poster | ELSA-ID: 2984
Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche
F. Drews, G. Drews, C. Folz, G. Platz, T. Gassenmeier, M. Kramer, C. Hundeiker, B. Schwarze, B. Frahm, Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche, 2014.
ELSA
 
[72]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
Seed train optimization for suspension cell culture
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, BioMed Central , 2013.
ELSA | DOI | Download (ext.)
 
[71]
2013 | Konferenzband - Beitrag | ELSA-ID: 2818 | OA
Model-based design of the first steps of a seed train for cell culture processes
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes, BioMed Central, 2013.
ELSA | DOI | Download (ext.)
 
[70]
2013 | Sammelwerk - Beitrag | ELSA-ID: 10214
Seed Train Optimization for Cell Culture
B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013, pp. 355–367.
ELSA | DOI
 
[69]
2013 | Konferenz - Poster | ELSA-ID: 2980
Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse, 2013.
ELSA
 
[68]
2013 | Konferenz - Poster | ELSA-ID: 2981
Model-based design of the first steps of a seed train for cell culture processes
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes, 2013.
ELSA
 
[67]
2013 | Konferenz - Poster | ELSA-ID: 2982
Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags
T. Hahne, B. Schwarze, J. Moschinski, A. Kuttig, M. Kramer, B. Frahm, Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags, 2013.
ELSA
 
[66]
2013 | Konferenz - Poster | ELSA-ID: 2983
Seed train optimization for suspension cell culture
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, 2013.
ELSA
 
[65]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 | OA
Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA), Springer, Dordrecht, 2012.
ELSA | DOI | Download (ext.)
 
[64]
2012 | Patent | ELSA-ID: 2877
Photobioreaktor mit rotatorisch oszillierenden Lichtquellen
H. Brod, B. Frahm, (2012).
ELSA
 
[63]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, Vogel Business Media, 2012.
ELSA
 
[62]
2012 | Konferenz - Poster | ELSA-ID: 2973
Optimierung des Seed trains von Suspensions-Zellkulturen
R. Marzougui, R. Pörtner, B. Frahm, Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.
ELSA
 
[61]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, J. Dewulf, H. Van Langenhove, R. Ludwig, Journal of Molecular Catalysis B: Enzymatic 68 (2011) 154–161.
ELSA | DOI | Download (ext.)
 
[60]
2011 | Patent | ELSA-ID: 2876
Flüssigkeitsbegaser
H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, J. Seletzky, (2011).
ELSA
 
[59]
2011 | Konferenz - Poster | ELSA-ID: 2972
Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, 2011.
ELSA
 
[58]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Intensified absorption and distillation devices for modular chemical production processes
B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, Czech Society of Chemical Engineering, 2010.
ELSA
 
[57]
2010 | Patent | ELSA-ID: 2873
Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen
H. Brod, B. Frahm, J. Kauling, (2010).
ELSA
 
[56]
2010 | Patent | ELSA-ID: 2874
Bioreaktor
H. Brod, B. Frahm, M. Jenne, J. Kauling, (2010).
ELSA
 
[55]
2010 | Patent | ELSA-ID: 2875
Begasungssystem
B. Frahm, J. Kauling, A. Pütz, M. Schindler, (2010).
ELSA
 
[54]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration
B. Frahm, H. Brod, Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration, 2010.
ELSA
 
[53]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Intensified absorption and distillation devices for modular chemical production processes
B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, 2010.
ELSA
 
[52]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 | OA
Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration
B. Frahm, H. Brod, U. Langer, Cytotechnology 59 (2009) 17–30.
ELSA | DOI | Download (ext.)
 
[51]
2009 | Patent | ELSA-ID: 2872
Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen
A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, (2009).
ELSA
 
[50]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, U. Langer, Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[49]
2009 | Konferenz - Poster | ELSA-ID: 2970
Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, U. Langer, Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[48]
2009 | Konferenz - Poster | ELSA-ID: 2971
Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor
W. Van Hecke, H. Van Langenhovve, B. Frahm, H. Brod, J. Dewulf, D. Haltrich, R. Ludwig, Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor, 2009.
ELSA
 
[47]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Pushing the Limits in High-Density Mammalian Cell Fermentation
H. Brod, J. Kauling, B. Frahm, M. Jenne, U. Langer, B. Bödeker, Pushing the Limits in High-Density Mammalian Cell Fermentation, 2008.
ELSA
 
[46]
2008 | Konferenz - Poster | ELSA-ID: 2968
High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, M. Burnett, U. Langer, B. Bödeker, High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[45]
2008 | Konferenz - Poster | ELSA-ID: 2969
High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[44]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien
B. Frahm, S. Kirchner, J. Kauling, H. Brod, U. Langer, B. Bödeker, Chemie Ingenieur Technik 79 (2007) 1052–1058.
ELSA | DOI | Download (ext.)
 
[43]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller
R. Pörtner, B. Frahm, P. Lane, A. Munack, K. Kühn, V.C. Hass, Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller, Springer, Dordrecht, 2007.
ELSA | DOI
 
[42]
2007 | Patent | ELSA-ID: 2870 | OA
Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component
H. Brod, B. Frahm, J. Kauling, R. Rose, (2007).
ELSA | Download (ext.)
 
[41]
2007 | Patent | ELSA-ID: 2871
Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen
H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, S. Schmidt, (2007).
ELSA
 
[40]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen
H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[39]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen
H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[38]
2007 | Konferenz - Poster | ELSA-ID: 2967
High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)
B. Frahm, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, B. Bödeker, High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2007.
ELSA
 
[37]
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 | OA
Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode
B. Frahm, P. Lane, A. Munack, R. Pörtner, Chemie Ingenieur Technik 77 (2005) 429–435.
ELSA | DOI | Download (ext.)
 
[36]
2005 | Konferenzband - Beitrag | ELSA-ID: 2813
Flexible Fed-Batch Process Control of Animal Cells
B. Frahm, R. Pörtner, Flexible Fed-Batch Process Control of Animal Cells, Springer, Dordrecht, 2005.
ELSA | DOI
 
[35]
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Optimisation of time-space-yield for hybridoma fed-batch cultures with an adaptive OLFO-controller
R. Pörtner, B. Frahm, P. Lane, A. Munack, Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive OLFO-Controller, 2005.
ELSA
 
[34]
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode
R. Pörtner, B. Frahm, V.C. Hass, P. Lane, A. Munack, Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode, 2005.
ELSA
 
[33]
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 | OA
Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line
R. Pörtner, J.-O. Schwabe, B. Frahm, Biotechnology and Applied Biochemistry 40 (2004).
ELSA | DOI | Download (ext.)
 
[32]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 | OA
Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung
B. Frahm, V.C. Hass, P. Lane, A. Munack, H. Märkl, R. Pörtner, Chemie Ingenieur Technik 75 (2003) 457–460.
ELSA | DOI | Download (ext.)
 
[31]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 | OA
Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis
B. Frahm, P. Lane, H. Märkl, R. Pörtner, Bioprocess and Biosystems Engineering 26 (2003) 1–10.
ELSA | DOI | Download (ext.)
 
[30]
2003 | Dissertation | ELSA-ID: 2393
Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen
B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003.
ELSA
 
[29]
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control
B. Frahm, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control, Inst. für Bioprozess- und Analysenmesstechnik , Heiligenstadt, 2003.
ELSA
 
[28]
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells
K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. Hass, Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, ECCE4, Granada, 2003.
ELSA
 
[27]
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung
B. Frahm, R. Pörtner, Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung, 2003.
ELSA
 
[26]
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung
V.C. Hass, K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung, 2003.
ELSA
 
[25]
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies
B. Frahm, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies, 2003.
ELSA | Dateien verfügbar
 
[24]
2003 | Konferenz - Vortrag | ELSA-ID: 2906
Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung
R. Pörtner, B. Frahm, P. Lane, V.C. Hass, A. Munack, H. Märkl, Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung, 2003.
ELSA
 
[23]
2003 | Konferenz - Poster | ELSA-ID: 2964
CO2-off-gas measurement for animal cell culture processes
B. Frahm, R. Pörtner, CO2-off-Gas Measurement for Animal Cell Culture Processes, 2003.
ELSA
 
[22]
2003 | Konferenz - Poster | ELSA-ID: 2965
Flexible fed-batch process control of animal cells
B. Frahm, R. Pörtner, Flexible Fed-Batch Process Control of Animal Cells, 2003.
ELSA
 
[21]
2003 | Konferenz - Poster | ELSA-ID: 2966
Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells
K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. Hass, Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, 2003.
ELSA
 
[20]
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies
B. Frahm, R. Pörtner, Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies, 2003.
ELSA
 
[19]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 | OA
Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement
B. Frahm, H.-C. Blank, P. Cornand, W. Oelßner, U. Guth, P. Lane, A. Munack, K. Johannsen, R. Pörtner, Journal of Biotechnology 99 (2002) 133–148.
ELSA | DOI | Download (ext.)
 
[18]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 | OA
Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells
B. Frahm, P. Lane, H. Atzert, A. Munack, M. Hoffmann, V.C. Hass, R. Pörtner, Biotechnology Progress 18 (2002) 1095–1103.
ELSA | DOI | Download (ext.)
 
[17]
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Reaktor-Abgasmessungen bei Zellkulturen
B. Frahm, R. Pörtner, BIOforum 4 (2002) 179–180.
ELSA
 
[16]
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen
B. Frahm, R. Pörtner, Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen, Kurt-Schwabe-Inst. , Meinsberg , 2002.
ELSA
 
[15]
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen
B. Frahm, R. Pörtner, Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen, 2002.
ELSA
 
[14]
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells
B. Frahm, R. Pörtner, Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells, 2002.
ELSA
 
[13]
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells
B. Frahm, R. Pörtner, Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells, 2002.
ELSA
 
[12]
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control
B. Frahm, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control, 2002.
ELSA
 
[11]
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells
B. Frahm, H. Atzert, P. Lane, M. Hoffmann, V.C. Hass, A. Munack, R. Pörtner, Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells, Springer, Dordrecht, 2001.
ELSA | DOI
 
[10]
2001 | Konferenz - Poster | ELSA-ID: 2429
Model-Based Control of Hybridoma Cell Cultures
V.C. Hass, P. Lane, M. Hoffmann, B. Frahm, J.-O. Schwabe, R. Pörtner, A. Munack, Model-Based Control of Hybridoma Cell Cultures, 2001.
ELSA
 
[9]
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen
M. Hoffmann, V.C. Hass, B. Frahm, J.-O. Schwabe, R. Pörtner, P. Lane, A. Munack, Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen, 2001.
ELSA
 
[8]
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik
B. Frahm, R. Pörtner, Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik, 2001.
ELSA
 
[7]
2001 | Konferenz - Poster | ELSA-ID: 2960
Adaptive modellgestützte Steuerung von Zellkulturprozessen
B. Frahm, H. Atzert, J.-O. Schwabe, P. Lane, A. Munack, M. Hoffmann, V.C. Hass, R. Pörtner, Adaptive Modellgestützte Steuerung von Zellkulturprozessen, 2001.
ELSA
 
[6]
2001 | Konferenz - Poster | ELSA-ID: 2961
Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities
P. Lane, B. Frahm, H. Atzert, J.-O. Schwabe, M. Hoffmann, V.C. Hass, R. Pörtner, Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities, 2001.
ELSA
 
[5]
2001 | Konferenz - Poster | ELSA-ID: 2962
Development of an automated, model-based, adaptive control for the effective cultivation of hybridoma cells
B. Frahm, H. Atzert, P. Lane, M. Hoffmann, V.C. Hass, A. Munack, R. Pörtner, Development of an Automated, Model-Based, Adaptive Control for the Effective Cultivation of Hybridoma Cells, 2001.
ELSA
 
[4]
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 | OA
Model-Based Control of Hybridoma Cell Cultures
V.C. Hass, P. Lane, M. Hoffmann, B. Frahm, J.-O. Schwabe, R. Pörtner, A. Munack, Model-Based Control of Hybridoma Cell Cultures, ScienceDirect, Oxford, 2001.
ELSA | DOI | Download (ext.)
 
[3]
2001 | Konferenz - Vortrag | ELSA-ID: 7933
Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen
B. Frahm, R. Pörtner, Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen, 2001.
ELSA
 
[2]
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren
T. Anderelei, B. Frahm, J. Büchs, Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren, 2000.
ELSA
 
[1]
2000 | Konferenz - Poster | ELSA-ID: 2959
Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus
M. Hoffmann, B. Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V.C. Hass, A. Munack, Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus, 2000.
ELSA
 
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[168]
2024 | Konferenz - Vortrag | ELSA-ID: 12021
Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie
J. Segermann, M. Luttmann, A. Blome, S. Feldt, S. Sivanesan, C.-A. Holst, V. Lohweg, B. Frahm, U. Müller, Die Rolle von ML-Modellen in der Lebensmitteltechnologie: Eine Fallstudie zur Sauerteigfermentation mit NIR-Spektroskopie, 2024.
ELSA
 
[167]
2024 | Konferenz - Vortrag | ELSA-ID: 12022
Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen
M. Luttmann, A. Blome, J. Segermann, M. Jekle, B. Frahm, U. Müller, Erkenntnisse zur Nutzung von Photogrammmetrie für die Untersuchung des Bräunungsverhaltens von Weizenbrötchen, 2024.
ELSA
 
[166]
2024 | Konferenz - Poster | ELSA-ID: 12395
Investigation of microbial spoilage in vegan foods
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Investigation of Microbial Spoilage in Vegan Foods, 2024.
ELSA
 
[165]
2024 | Konferenz - Poster | ELSA-ID: 12396
Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-situ Monitoring of Hybridoma Cell Culture
V. Gassenmeier, G. Campolongo, B. Frahm, Dissolved Carbon Dioxide in Addition to Dissolved Oxygen for In-Situ Monitoring of Hybridoma Cell Culture, 2024.
ELSA
 
[164]
2024 | Konferenz - Poster | ELSA-ID: 12397
Process optimization in baked goods production using inline sensors and objective product evaluation
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process Optimization in Baked Goods Production Using Inline Sensors and Objective Product Evaluation, 2024.
ELSA
 
[163]
2024 | Preprint | ELSA-ID: 12400 | OA
Semi-automated vs. manual: Comparative study of cell culture counting methods using validation parameters
S. Ramm, U. Odefey, B. Frahm, M. Pein-Hackelbusch, (2024).
ELSA | DOI | Download (ext.)
 
[162]
2024 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 12402
Comparative Analysis of pH Prediction Routines in ADM1 and a Specialized Water Chemistry Simulator
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 96 (2024) 528–534.
ELSA | DOI | WoS
 
[161]
2024 | Konferenz - Poster | ELSA-ID: 10957
Mycelium-based materials from residues of the regional wood industry
L. Reinhardt, V. Gassenmeier, S. Feldt, S. Plate, M. Tremmel, B. Frahm, M. Stosch, Mycelium-Based Materials from Residues of the Regional Wood Industry, n.d.
ELSA
 
[160]
2023 | Konferenz - Poster | ELSA-ID: 12483
Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung, 2023.
ELSA
 
[159]
2023 | Konferenz - Poster | ELSA-ID: 12485
Teig 4.0 - Promotionsthemen
M. Luttmann, A. Blome, M. Jekle, B. Frahm, U. Müller, Teig 4.0 - Promotionsthemen, 2023.
ELSA
 
[158]
2023 | Konferenz - Vortrag | ELSA-ID: 11109
Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung
A. Blome, M. Luttmann, M. Jekle, B. Frahm, U. Müller, Untersuchung der räumlichen Verteilung von viskoelastischen Kenngrößen während der Weizenteigbereitung, 2023.
ELSA
 
[157]
2023 | Konferenz - Poster | ELSA-ID: 11110
Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Vorstellung des Projektes „Teig 4.0“ - Prozessoptimierung im Bereich der industriellen Weizenteigverarbeitung, 2023.
ELSA
 
[156]
2023 | Konferenz - Poster | ELSA-ID: 11378
Real-time Monitoring of DCO2 in addition to DO
V. Gassenmeier, G. Campolongo, B. Frahm, Real-Time Monitoring of DCO2 in Addition to DO, n.d.
ELSA
 
[155]
2023 | Konferenz - Poster | ELSA-ID: 11381
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, DECHEMA e.V., n.d.
ELSA
 
[154]
2023 | Konferenz - Poster | ELSA-ID: 11382 | OA
View on a mechanistic model of Chlorella vulgaris in shake flasks
V. Gassenmeier, F. Kuhfuß, S. Deppe, G. Ifrim, T. Hernández Rodriguez, B. Frahm, View on a Mechanistic Model of Chlorella Vulgaris in Shake Flasks, n.d.
ELSA | Download (ext.)
 
[153]
2023 | Konferenz - Vortrag | ELSA-ID: 11383
Model-assisted design strategies for bioprocesses – Advanced statistical methods in industrial upstream cell culture
T. Hernández Rodriguez, C. Posch, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, Model-Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, DECHEMA e.V., 2023.
ELSA
 
[152]
2023 | Konferenzband - Beitrag | ELSA-ID: 11384 | OA
Microbial spoilage in vegan foods
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial Spoilage in Vegan Foods, Croatian Society of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, Editors: Draženka Komes, Sanja Vidaček Filipec and Bojana Voučko, 2023.
ELSA | Download (ext.)
 
[151]
2023 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11385
Validation and Uncertainty Assessment of a Software‐Integrated Workflow for pH Calculations
P. Kosse, T. Hernández Rodriguez, B. Frahm, M. Lübken, M. Wichern, Chemie Ingenieur Technik 95 (2023) 1960–1969.
ELSA | DOI | WoS
 
[150]
2023 | Konferenz - Poster | ELSA-ID: 11487 | OA
Comparison of Preprocessing Methods of Dielectric Spectroscopy Data and the Effects on Linear Regression
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Comparison of Preprocessing Methods of Dielectric Spectroscopy  Data and the Effects on Linear Regression , DECHEMA e.V., n.d.
ELSA | Download (ext.)
 
[149]
2023 | Konferenz - Poster | ELSA-ID: 10201 | OA
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, 2023.
ELSA | Download (ext.)
 
[148]
2023 | Konferenzband - Beitrag | ELSA-ID: 10788 | OA
Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities
S. Ramm, T. Hernández Rodriguez, B. Frahm, M. Pein-Hackelbusch, Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities, IEEE, [Piscataway, NJ], 2023.
ELSA | DOI | Download (ext.)
 
[147]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11377
Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biopharmaceutical Seed Train Design
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, Processes 10 (2022).
ELSA | DOI
 
[146]
2022 | Datenpublikation | ELSA-ID: 10190
Real-time Monitoring of DCO2 in addition to DO
V. Gassenmeier, B. Frahm, Real-Time Monitoring of DCO2 in Addition to DO, assets-labs, 2022.
ELSA | Dateien verfügbar
 
[145]
2022 | Sammelwerk - Beitrag | ELSA-ID: 10193
Designing robust biotechnological processes regarding variabilities using multi-objective optimization applied to a biopharmaceutical seed train design
T. Hernández Rodriguez, A. Sekulic, M. Lange-Hegermann, B. Frahm, in: R. Pörtner, J. Möller (Eds.), Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2022, pp. 21–48.
ELSA | DOI
 
[144]
2022 | Konferenzband - Beitrag | ELSA-ID: 10195
Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products, Versuchsanstalt der Hefeindustrie e.V., 2022.
ELSA
 
[143]
2022 | Konferenz - Vortrag | ELSA-ID: 10196
Process optimisation in the field of wheat dough processing using real-time recording of quality-relevant characteristics in raw materials, intermediates and final products
A. Blome, M. Luttmann, J. Segermann, M. Jekle, B. Frahm, U. Müller, Process Optimisation in the Field of Wheat Dough Processing Using Real-Time Recording of Quality-Relevant Characteristics in Raw Materials, Intermediates and Final Products, 2022.
ELSA
 
[142]
2022 | Konferenz - Vortrag | ELSA-ID: 10197
Model assisted Design Strategies for Bioprocesses – Advanced statistical methods in industrial upstream cell culture
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Model Assisted Design Strategies for Bioprocesses – Advanced Statistical Methods in Industrial Upstream Cell Culture, 2022.
ELSA
 
[141]
2022 | Konferenz - Poster | ELSA-ID: 10198
A systematic, model-based approach for decision making in upstream development – Considerations regarding clone selection and cell expansion
T. Hernández Rodriguez, R. Pörtner, M. Lange-Hegermann, F.M. Wurm, B. Frahm, A Systematic, Model-Based Approach for Decision Making in Upstream Development – Considerations Regarding Clone Selection and Cell Expansion, n.d.
ELSA
 
[140]
2022 | Konferenz - Poster | ELSA-ID: 10199 | OA
Microbial spoilage in vegan foods
C. Müller, J. Alarinta, B. Frahm, G. Wirtanen, Microbial Spoilage in Vegan Foods, 2022.
ELSA | Download (ext.)
 
[139]
2022 | Konferenz - Poster | ELSA-ID: 7932
A systematic, model-based workflow for risk-based decision making in upstream development
T. Hernández Rodriguez, S. Ramm, M. Lange-Hegermann, B. Frahm, A Systematic, Model-Based Workflow for Risk-Based Decision Making in Upstream Development, n.d.
ELSA
 
[138]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7976
Model-assisted DoE applied to microalgae processes, Current Research in Biotechnology
V. Gassenmeier, S. Deppe, T. Hernández Rodriguez, F. Kuhfuß, A. Moser, V.C. Hass, K.B. Kuchemüller, R. Pörtner, J. Möller, G.A. Ifrim, B. Frahm, Current Research in Biotechnology 4 (2022) 102–119.
ELSA | DOI
 
[137]
2022 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7977
View on a mechanistic model of Chlorella vulgaris in incubated shake flasks
F. Kuhfuß, V. Gassenmeier, S. Deppe, G.A. Ifrim, T. Hernández Rodriguez, B. Frahm, Bioprocess and Biosystems Engineering 45 (2022) 15–30.
ELSA | DOI
 
[136]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 11376
Considerations of the Impacts of Cell-Specific Growth and Production Rate on Clone Selection—A Simulation Study
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, Processes 9 (2021).
ELSA | DOI
 
[135]
2021 | Sammelwerk - Beitrag | ELSA-ID: 3349
Digital Seed Train Twins and Statistical Methods
T. Hernández Rodriguez, B. Frahm, in: C. Herwig, R. Pörtner, J. Möller (Eds.), Digital Twins Tools and Concepts for Smart Biomanufacturing, Springer, Berlin, Heidelberg, 2021, pp. 97–131.
ELSA | DOI
 
[134]
2021 | Konferenz - Vortrag | ELSA-ID: 7927
Model-based methods in bioprocess technology - Bioprocess modeling, simulation and prediction
T. Hernández Rodriguez, B. Frahm, Model-Based Methods in Bioprocess Technology - Bioprocess Modeling, Simulation and Prediction, 2021.
ELSA
 
[133]
2021 | Konferenz - Poster | ELSA-ID: 7931
Model-assisted Design of Experiments - Concept, Software and Applications
A. Moser, J. Möller, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, B. Frahm, R. Pörtner, V.C. Hass, Model-Assisted Design of Experiments - Concept, Software and Applications, 2021.
ELSA
 
[132]
2021 | Lexikoneintrag | ELSA-ID: 7939
Bovine Colostrum for Human Consumption
G. Wirtanen, J. Alarinta, B. Frahm, S. Fasse, in: MDPI Encyclopedia, Scholarly Community Encyclopedia, Category: Agriculture, Dairy & Animal Science, 2021.
ELSA
 
[131]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7981
Bovine Colostrum for Human Consumption - Improving Microbial Quality and Maintaining Bioactive Characteristics through Processing
S. Fasse, J. Alarinta, B. Frahm, G. Wirtanen, Dairy 2 (2021) 556–575.
ELSA | DOI | WoS
 
[130]
2021 | Sammelwerk - Beitrag | ELSA-ID: 7983
Considerations of the impacts of cell-specific growth and production rate on clone selection – a simulation study
T. Hernández Rodriguez, S. Morerod, R. Pörtner, F.M. Wurm, B. Frahm, in: Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing, MDPI, Basel, 2021, pp. 49–74.
ELSA | DOI
 
[129]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7985
Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation - applied to an industrial cell culture seed train
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Bioprocess and Biosystems Engineering 44 (2021) 793–808.
ELSA | DOI
 
[128]
2021 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 7986
Model-assisted DoE software: Optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses
A. Moser, K.B. Kuchemüller, S. Deppe, T. Hernández Rodriguez, B. Frahm, R. Pörtner, V.C. Hass, J. Möller, Bioprocess and Biosystems Engineering 44 (2021) 683–700.
ELSA | DOI
 
[127]
2021 | Konferenz - Vortrag | ELSA-ID: 8078
Messtechnikkonzepte für die Erfassung von qualitätsrelevanten Parametern und Merkmalen bei der Weizenteigverarbeitung
A. Blome, M. Luttmann, B. Frahm, U. Müller, Messtechnikkonzepte Für Die Erfassung von Qualitätsrelevanten Parametern Und Merkmalen Bei Der Weizenteigverarbeitung, 2021.
ELSA
 
[126]
2020 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2392
Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes
J. Möller, T. Hernández Rodríguez, J. Müller, L. Arndt, K.B. Kuchemüller, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Computers & Chemical Engineering 134 (2020) 1–13.
ELSA | DOI
 
[125]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2397
Design, Optimization and Adaptive Control of Cell Culture Seed Trains
T. Hernández Rodríguez, B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, Springer, Berlin, Heidelberg, New York, 2020, pp. 251–267.
ELSA | DOI
 
[124]
2020 | Sammelwerk - Beitrag | ELSA-ID: 2399
Estimation of Process Model Parameters
S. Deppe, B. Frahm, V.C. Hass, T. Hernández Rodríguez, K.B. Kuchemüller, J. Möller, R. Pörtner, in: R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols, Springer, Berlin ; Heidelberg ; New York, 2020, pp. 213–234.
ELSA | DOI
 
[123]
2020 | Konferenzband - Beitrag | ELSA-ID: 2822
Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, Claus Weihs, R. Pörtner, B. Frahm, Predicting Industrial Cell Culture Seed Trains - A Bayesian Approach, BioMed Central, 2020.
ELSA | Dateien verfügbar | DOI
 
[122]
2020 | Konferenz - Poster | ELSA-ID: 3007
Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration
F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, S. Deppe, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.
ELSA
 
[121]
2020 | Konferenz - Poster | ELSA-ID: 3008
Model-assisted Design of Experiments for algae cultivation
S. Deppe, F. Kuhfuß, M. Tölle, T. Hernández Rodriguez, V. Gassenmeier, G.A. Ifrim, J. Möller, R. Pörtner, A. Moser, V.C. Hass, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2020.
ELSA
 
[120]
2020 | Konferenz - Poster | ELSA-ID: 3009
Modeling of microalgae in an air-lift photobioreactor for biomass production
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2020.
ELSA
 
[119]
2020 | Konferenz - Poster | ELSA-ID: 7929
Modeling of Chlorella vulgaris in shake flasks with respect to light intensity and light duration
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris in Shake Flasks with Respect to Light Intensity and Light Duration, 2020.
ELSA
 
[118]
2020 | Konferenz - Poster | ELSA-ID: 7930
Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, 2020.
ELSA
 
[117]
2020 | Konferenz - Vortrag | ELSA-ID: 7936
Integration of prior knowledge and digital tools for uncertainty-based decision support
T. Hernández Rodriguez, B. Frahm, C. Posch, Integration of Prior Knowledge and Digital Tools for Uncertainty-Based Decision Support, 2020.
ELSA
 
[116]
2020 | Konferenzband - Beitrag | ELSA-ID: 7937
Modeling of Chlorella vulgaris algae in shake flasks with respect to light intensity and light duration
T. Hernández Rodriguez, S. Deppe, V. Gassenmeier, F. Kuhfuß, M. Tölle, G.A. Ifrim, B. Frahm, Modeling of Chlorella Vulgaris Algae in Shake Flasks with Respect to Light Intensity and Light Duration, Wiley, 2020.
ELSA | DOI
 
[115]
2020 | Konferenzband - Beitrag | ELSA-ID: 7938
Towards integration of prior knowledge and propagation of uncertainty for digital twins of biopharmaceutical production processes
T. Hernández Rodriguez, C. Posch, R. Pörtner, B. Frahm, Towards Integration of Prior Knowledge and Propagation of Uncertainty for Digital Twins of Biopharmaceutical Production Processes, Wiley, 2020.
ELSA | DOI
 
[114]
2019 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2391 | OA
Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, C. Weihs, R. Pörtner, B. Frahm, Biotechnology and Bioengineering 116 (2019) 2944–2959.
ELSA | DOI | Download (ext.)
 
[113]
2019 | Konferenzband - Beitrag | ELSA-ID: 2400
Multivariable control strategy for the photosynthetic cultures of microalgae
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae, IEEE, 2019.
ELSA | DOI
 
[112]
2019 | Konferenz - Vortrag | ELSA-ID: 2956
Workflow for model-assisted design and scale-up of biopharmaceutical production processes
J. Möller, J. Müller, T. Hernández Rodriguez, K.B. Kuchemüller, L. Arndt, B. Frahm, R. Eibl, D. Eibl, R. Pörtner, Workflow for Model-Assisted Design and Scale-up of Biopharmaceutical Production Processes, 2019.
ELSA
 
[111]
2019 | Konferenz - Vortrag | ELSA-ID: 2957
Model-Assisted Design of Experiments
J. Möller, K.B. Kuchemüller, A. Moser, V.C. Hass, T. Hernández Rodriguez, S. Deppe, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments, 2019.
ELSA
 
[110]
2019 | Konferenz - Vortrag | ELSA-ID: 2958
Novel control strategy for microalgae in photobioreactor
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Novel Control Strategy for Microalgae in Photobioreactor, 2019.
ELSA
 
[109]
2019 | Konferenz - Poster | ELSA-ID: 3000
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[108]
2019 | Konferenz - Poster | ELSA-ID: 3001
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[107]
2019 | Konferenz - Poster | ELSA-ID: 3002
Model-Assisted Design of Experiments – Software Toolbox
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, S. Deppe, G.A. Ifrim, A. Moser, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Design of Experiments – Software Toolbox, 2019.
ELSA
 
[106]
2019 | Konferenz - Poster | ELSA-ID: 3003
Model-assisted Design of Experiments for algae cultivation
S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, M. Tölle, F. Kuhfuß, J. Möller, K.B. Kuchemüller, R. Pörtner, A. Moser, V.C. Hass, G.A. Ifrim, B. Frahm, Model-Assisted Design of Experiments for Algae Cultivation, 2019.
ELSA
 
[105]
2019 | Konferenz - Poster | ELSA-ID: 3004
Modeling of microalgae in an air-lift photobioreactor for biomass production
G.A. Ifrim, S. Deppe, T. Hernández Rodriguez, V. Gassenmeier, B. Frahm, Modeling of Microalgae in an Air-Lift Photobioreactor for Biomass Production, 2019.
ELSA
 
[104]
2019 | Konferenz - Poster | ELSA-ID: 3005
Predicting industrial scale cell culture seed trains – considerations of input uncertainty, new process data and prognostic intervals using a Bayesian approach and sequential Bayesian updating
T. Hernández Rodriguez, C. Posch, J. Schmutzhard, J. Stettner, J. Weihs, R. Pörtner, B. Frahm, Predicting Industrial Scale Cell Culture Seed Trains – Considerations of Input Uncertainty, New Process Data and Prognostic Intervals Using a Bayesian Approach and Sequential Bayesian Updating, 2019.
ELSA
 
[103]
2019 | Konferenz - Poster | ELSA-ID: 3006
Multivariable control strategy for the photosynthetic cultures of microalgae
G.A. Ifrim, M. Titica, S. Deppe, B. Frahm, M. Barbu, S. Caraman, Multivariable Control Strategy for the Photosynthetic Cultures of Microalgae, 2019.
ELSA
 
[102]
2019 | Konferenz - Vortrag | ELSA-ID: 7928
Scale-up of stirred vessels
B. Frahm, Scale-up of Stirred Vessels, 2019.
ELSA
 
[101]
2018 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2390 | OA
Model-Assisted Design of Process Strategies for Cell Culture Processes
J. Möller, K.B. Kuchemüller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, American Pharmaceutical Review 3 (2018) 39–41.
ELSA | Download (ext.)
 
[100]
2018 | Konferenzband - Beitrag | ELSA-ID: 2821
Model-assisted cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Assisted Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, BioMed Central, 2018.
ELSA | Dateien verfügbar | DOI
 
[99]
2018 | Konferenz - Vortrag | ELSA-ID: 2955
Model-Assisted Design of Process Strategies for Cell Culture Processes
R. Pörtner, J. Möller, B. Frahm, V.C. Hass, Model-Assisted Design of Process Strategies for Cell Culture Processes, 2018.
ELSA
 
[98]
2018 | Konferenz - Poster | ELSA-ID: 2997
Model-Assisted Design and Optimization of Process Strategies
J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, T. Hernández Rodriguez, B. Frahm, V.C. Hass, R. Pörtner, Model-Assisted Design and Optimization of Process Strategies, 2018.
ELSA
 
[97]
2018 | Konferenz - Poster | ELSA-ID: 2999
Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses
T. Hernández Rodriguez, J. Möller, K.B. Kuchemüller, F. Freiberger, P. Levermann, V.C. Hass, B. Frahm, R. Pörtner, Model-Assisted Strategies for Design, Optimization and Control of Bioprocesses, 2018.
ELSA
 
[96]
2018 | Konferenz - Vortrag | ELSA-ID: 7935
A model-assisted approach for design, optimization and control of bioprocesses – a software tool for seed train simulation and optimization
T. Hernández Rodriguez, B. Frahm, C. Posch, J. Schmutzhard, J. Stettner, A Model-Assisted Approach for Design, Optimization and Control of Bioprocesses – a Software Tool for Seed Train Simulation and Optimization, 2018.
ELSA
 
[95]
2017 | Konferenz - Vortrag | ELSA-ID: 2920
Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren
T. Hernández Rodriguez, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[94]
2017 | Konferenz - Vortrag | ELSA-ID: 2921
Model-assisted design and optimization of biotechnological processes
R. Pörtner, J. Möller, T. Hernández Rodriguez, B. Frahm, V.C. Hass, Model-Assisted Design and Optimization of Biotechnological Processes, 2017.
ELSA
 
[93]
2017 | Konferenz - Vortrag | ELSA-ID: 2950
Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren
T. Hernández Rodriguez, K.S. Koopmann, J. Klaes, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, Produktion von Biopharmazeutika – Ein MATLAB©-Tool zur Simulation und Optimierung von Zellvermehrungsverfahren, 2017.
ELSA
 
[92]
2017 | Konferenz - Poster | ELSA-ID: 2994
Influence of parameter accuracies in cell culture seed train simulations
T. Hernández Rodriguez, K.S. Koopmann, R. Pörtner, B. Frahm, Influence of Parameter Accuracies in Cell Culture Seed Train Simulations, 2017.
ELSA
 
[91]
2017 | Konferenz - Poster | ELSA-ID: 2995
Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, J. Möller, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017.
ELSA
 
[90]
2017 | Konferenz - Poster | ELSA-ID: 2996
Model-based cell culture control – unstructured, unsegregated models as a key element for adaptive seed train and fed-batch optimization
T. Hernández Rodriguez, S. Krull, V.C. Hass, R. Pörtner, B. Frahm, Model-Based Cell Culture Control – Unstructured, Unsegregated Models as a Key Element for Adaptive Seed Train and Fed-Batch Optimization, 2017.
ELSA
 
[89]
2016 | Sammelwerk - Beitrag | ELSA-ID: 2395
Advanced Process and Control Strategies for Bioreactors
R. Pörtner, O. Platas Barradas, B. Frahm, V.C. Hass, in: Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls, Elsevier, Amsterdam, 2016, pp. 463–493.
ELSA | DOI
 
[88]
2016 | Konferenz - Poster | ELSA-ID: 2991
DMA Photobioreactor System – Cultivation at low shear stress and optional membrane aeration
U. Beshay, S. Feldt, B. Schwarze, P. Wefing, T. Hahne, J. Moschinski, C. Müller, R. Büker, M. Kramer, H. Brod, B. Frahm, DMA Photobioreactor System – Cultivation at Low Shear Stress and Optional Membrane Aeration, 2016.
ELSA
 
[87]
2016 | Konferenz - Poster | ELSA-ID: 2992
A software tool for biopharmaceutical seed train design and optimization
T. Hernández Rodriguez, S. Vörtler, S. Kern, O. Platas Barradas, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2016.
ELSA
 
[86]
2016 | Konferenz - Poster | ELSA-ID: 2993
Simulation of cell culture seed trains – investigation of the influence of parameter inaccuracies
K.S. Koopmann, T. Hernández Rodriguez, S. Vörtler, U. Beshay, J. Möller, R. Pörtner, B. Frahm, Simulation of Cell Culture Seed Trains – Investigation of the Influence of Parameter Inaccuracies, 2016.
ELSA
 
[85]
2015 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2389
Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas-Barradas, R. Pörtner, B. Frahm, Cytotechnology 68 (2015) 1019–1032.
ELSA | DOI | Download (ext.)
 
[84]
2015 | Konferenzband - Beitrag | ELSA-ID: 2819 | OA
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[83]
2015 | Konferenzband - Beitrag | ELSA-ID: 2820 | OA
Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas Barradas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale, BioMed Central, 2015.
ELSA | DOI | Download (ext.)
 
[82]
2015 | Konferenz - Vortrag | ELSA-ID: 2917
Seed train design and optimization for animal cell suspension culture
B. Frahm, R. Pörtner, S. Kern, T. Hernández Rodriguez, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015.
ELSA | Dateien verfügbar
 
[81]
2015 | Konferenz - Vortrag | ELSA-ID: 2919
Seed train design and optimization for animal cell suspension culture
B. Frahm, T. Hernández Rodriguez, S. Kern, K.S. Koopmann, U. Beshay, O. Platas-Barradas, R. Pörtner, Seed Train Design and Optimization for Animal Cell Suspension Culture, 2015.
ELSA
 
[80]
2015 | Konferenz - Poster | ELSA-ID: 2985
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015.
ELSA
 
[79]
2015 | Konferenz - Poster | ELSA-ID: 2986
Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale, 2015.
ELSA
 
[78]
2015 | Konferenz - Poster | ELSA-ID: 2987
A software tool for biopharmaceutical seed train design and optimization
T. Hernández Rodriguez, R. Pörtner, B. Frahm, A Software Tool for Biopharmaceutical Seed Train Design and Optimization, 2015.
ELSA
 
[77]
2015 | Konferenz - Poster | ELSA-ID: 2988
Considerations for cell passaging in cell culture seed trains
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Considerations for Cell Passaging in Cell Culture Seed Trains, 2015.
ELSA
 
[76]
2015 | Konferenz - Poster | ELSA-ID: 2990
Model-based strategy for cell culture seed train layout verified at lab scale
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Strategy for Cell Culture Seed Train Layout Verified at Lab Scale, 2015.
ELSA
 
[75]
2014 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2388
Disposable algae cultivation for high-value products using all around LED-illumination directly on the bags
T. Hahne, B. Schwarze, M. Kramer, B. Frahm, Journal of Algal Biomass Utilization 5 (2014) 66–73.
ELSA
 
[74]
2014 | Patent | ELSA-ID: 2878
Beleuchtung von disposable Bioreaktoren
B. Frahm, U. Meier, (2014).
ELSA
 
[73]
2014 | Konferenz - Poster | ELSA-ID: 2984
Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche
F. Drews, G. Drews, C. Folz, G. Platz, T. Gassenmeier, M. Kramer, C. Hundeiker, B. Schwarze, B. Frahm, Herstellung von Paramylon mit Euglena gracilis im disposable Bag mit LED-Beleuchtung direkt auf dessen Oberfläche, 2014.
ELSA
 
[72]
2013 | Konferenzband - Beitrag | ELSA-ID: 2817 | OA
Seed train optimization for suspension cell culture
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, BioMed Central , 2013.
ELSA | DOI | Download (ext.)
 
[71]
2013 | Konferenzband - Beitrag | ELSA-ID: 2818 | OA
Model-based design of the first steps of a seed train for cell culture processes
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes, BioMed Central, 2013.
ELSA | DOI | Download (ext.)
 
[70]
2013 | Sammelwerk - Beitrag | ELSA-ID: 10214
Seed Train Optimization for Cell Culture
B. Frahm, in: R. Pörtner (Ed.), Animal Cell Biotechnology - Methods and Protocols, 3rd ed., Humana Press, Totowa, NJ, 2013, pp. 355–367.
ELSA | DOI
 
[69]
2013 | Konferenz - Poster | ELSA-ID: 2980
Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Modellgestützte Auslegung der ersten Schritte eines Seed-Trains für Zellkulturprozesse, 2013.
ELSA
 
[68]
2013 | Konferenz - Poster | ELSA-ID: 2981
Model-based design of the first steps of a seed train for cell culture processes
S. Kern, O. Platas, M. Schaletzky, V. Sandig, B. Frahm, R. Pörtner, Model-Based Design of the First Steps of a Seed Train for Cell Culture Processes, 2013.
ELSA
 
[67]
2013 | Konferenz - Poster | ELSA-ID: 2982
Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags
T. Hahne, B. Schwarze, J. Moschinski, A. Kuttig, M. Kramer, B. Frahm, Disposable Algenkultivierung für hochpreisige Produkte mittels LED-Rundumbeleuchtung direkt auf den Bags, 2013.
ELSA
 
[66]
2013 | Konferenz - Poster | ELSA-ID: 2983
Seed train optimization for suspension cell culture
T. Hernández Rodriguez, R. Pörtner, B. Frahm, Seed Train Optimization for Suspension Cell Culture, 2013.
ELSA
 
[65]
2012 | Konferenzband - Beitrag | ELSA-ID: 2816 | OA
Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, Improving Cell Culture Bioreactor Performance for Sensitive Cell Lines by Dynamic Membrane Aeration (DMA), Springer, Dordrecht, 2012.
ELSA | DOI | Download (ext.)
 
[64]
2012 | Patent | ELSA-ID: 2877
Photobioreaktor mit rotatorisch oszillierenden Lichtquellen
H. Brod, B. Frahm, (2012).
ELSA
 
[63]
2012 | Konferenz - Vortrag | ELSA-ID: 2918
Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, Vogel Business Media, 2012.
ELSA
 
[62]
2012 | Konferenz - Poster | ELSA-ID: 2973
Optimierung des Seed trains von Suspensions-Zellkulturen
R. Marzougui, R. Pörtner, B. Frahm, Optimierung des Seed trains von Suspensions-Zellkulturen, 2012.
ELSA
 
[61]
2011 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2350
A biocatalytic cascade reaction sensitive to the gas–liquid interface: Modeling and upscaling in a dynamic membrane aeration reactor
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, J. Dewulf, H. Van Langenhove, R. Ludwig, Journal of Molecular Catalysis B: Enzymatic 68 (2011) 154–161.
ELSA | DOI | Download (ext.)
 
[60]
2011 | Patent | ELSA-ID: 2876
Flüssigkeitsbegaser
H. Brod, B. Frahm, M. Jenne, J. Kauling, F. Schmitt, J. Seletzky, (2011).
ELSA
 
[59]
2011 | Konferenz - Poster | ELSA-ID: 2972
Modelling and upscaling of a biocatalytic cascade oxidation in a dynamic membrane aeration reactor
W. Van Hecke, D. Haltrich, B. Frahm, H. Brod, R. Ludwig, Modelling and Upscaling of a Biocatalytic Cascade Oxidation in a Dynamic Membrane Aeration Reactor, 2011.
ELSA
 
[58]
2010 | Konferenzband - Beitrag | ELSA-ID: 2815
Intensified absorption and distillation devices for modular chemical production processes
B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, Czech Society of Chemical Engineering, 2010.
ELSA
 
[57]
2010 | Patent | ELSA-ID: 2873
Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen
H. Brod, B. Frahm, J. Kauling, (2010).
ELSA
 
[56]
2010 | Patent | ELSA-ID: 2874
Bioreaktor
H. Brod, B. Frahm, M. Jenne, J. Kauling, (2010).
ELSA
 
[55]
2010 | Patent | ELSA-ID: 2875
Begasungssystem
B. Frahm, J. Kauling, A. Pütz, M. Schindler, (2010).
ELSA
 
[54]
2010 | Konferenz - Vortrag | ELSA-ID: 2892
Cultivation of sensitive cell lines - Improving bioreactor performance by Dynamic Membrane Aeration
B. Frahm, H. Brod, Cultivation of Sensitive Cell Lines - Improving Bioreactor Performance by Dynamic Membrane Aeration, 2010.
ELSA
 
[53]
2010 | Konferenz - Vortrag | ELSA-ID: 2913
Intensified absorption and distillation devices for modular chemical production processes
B. Dercks, B. Frahm, M. Grünewald, E. Kenig, A. Lautenschleger, A. Gorak, P. Schmidt, D. Sudhoff, S. Ressler, R. Zecirovic, Intensified Absorption and Distillation Devices for Modular Chemical Production Processes, 2010.
ELSA
 
[52]
2009 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2349 | OA
Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration
B. Frahm, H. Brod, U. Langer, Cytotechnology 59 (2009) 17–30.
ELSA | DOI | Download (ext.)
 
[51]
2009 | Patent | ELSA-ID: 2872
Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen
A. Braun, H. Brod, B. Frahm, M. Jenne, J. Kauling, S. Kirchner, (2009).
ELSA
 
[50]
2009 | Konferenz - Vortrag | ELSA-ID: 2912
Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, U. Langer, Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[49]
2009 | Konferenz - Poster | ELSA-ID: 2970
Improving cell culture bioreactor performance by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, U. Langer, Improving Cell Culture Bioreactor Performance by Dynamic Membrane Aeration (DMA), 2009.
ELSA
 
[48]
2009 | Konferenz - Poster | ELSA-ID: 2971
Upscaling the biocatalytic conversion of lactose to lactobionic acid with the dynamic membrane aeration reactor
W. Van Hecke, H. Van Langenhovve, B. Frahm, H. Brod, J. Dewulf, D. Haltrich, R. Ludwig, Upscaling the Biocatalytic Conversion of Lactose to Lactobionic Acid with the Dynamic Membrane Aeration Reactor, 2009.
ELSA
 
[47]
2008 | Konferenz - Vortrag | ELSA-ID: 2911
Pushing the Limits in High-Density Mammalian Cell Fermentation
H. Brod, J. Kauling, B. Frahm, M. Jenne, U. Langer, B. Bödeker, Pushing the Limits in High-Density Mammalian Cell Fermentation, 2008.
ELSA
 
[46]
2008 | Konferenz - Poster | ELSA-ID: 2968
High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, M. Burnett, U. Langer, B. Bödeker, High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[45]
2008 | Konferenz - Poster | ELSA-ID: 2969
High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)
B. Frahm, H. Brod, High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2008.
ELSA
 
[44]
2007 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2348
Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien
B. Frahm, S. Kirchner, J. Kauling, H. Brod, U. Langer, B. Bödeker, Chemie Ingenieur Technik 79 (2007) 1052–1058.
ELSA | DOI | Download (ext.)
 
[43]
2007 | Konferenzband - Beitrag | ELSA-ID: 2814
Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller
R. Pörtner, B. Frahm, P. Lane, A. Munack, K. Kühn, V.C. Hass, Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive Olfo-Controller, Springer, Dordrecht, 2007.
ELSA | DOI
 
[42]
2007 | Patent | ELSA-ID: 2870 | OA
Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component
H. Brod, B. Frahm, J. Kauling, R. Rose, (2007).
ELSA | Download (ext.)
 
[41]
2007 | Patent | ELSA-ID: 2871
Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen
H. Brod, B. Frahm, J. Kauling, M. Poggel, R. Rose, S. Schmidt, (2007).
ELSA
 
[40]
2007 | Konferenz - Vortrag | ELSA-ID: 2909
Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen
H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[39]
2007 | Konferenz - Vortrag | ELSA-ID: 2910
Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen
H. Brod, B. Frahm, J. Kauling, Die dynamische Membranbegasung – ein Ansatz zur Intensivierung der Sauerstoffversorgung tierischer Zellkulturen, 2007.
ELSA
 
[38]
2007 | Konferenz - Poster | ELSA-ID: 2967
High cell density bioreactor cultivation by Dynamic Membrane Aeration (DMA)
B. Frahm, S. Kirchner, R. Rose, M. Jenne, J. Kauling, H. Brod, K. Jöris, M. Wischniewski, U. Langer, B. Bödeker, High Cell Density Bioreactor Cultivation by Dynamic Membrane Aeration (DMA), 2007.
ELSA
 
[37]
2005 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2347 | OA
Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode
B. Frahm, P. Lane, A. Munack, R. Pörtner, Chemie Ingenieur Technik 77 (2005) 429–435.
ELSA | DOI | Download (ext.)
 
[36]
2005 | Konferenzband - Beitrag | ELSA-ID: 2813
Flexible Fed-Batch Process Control of Animal Cells
B. Frahm, R. Pörtner, Flexible Fed-Batch Process Control of Animal Cells, Springer, Dordrecht, 2005.
ELSA | DOI
 
[35]
2005 | Konferenz - Vortrag | ELSA-ID: 2907
Optimisation of time-space-yield for hybridoma fed-batch cultures with an adaptive OLFO-controller
R. Pörtner, B. Frahm, P. Lane, A. Munack, Optimisation of Time-Space-Yield for Hybridoma Fed-Batch Cultures with an Adaptive OLFO-Controller, 2005.
ELSA
 
[34]
2005 | Konferenz - Vortrag | ELSA-ID: 2908
Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode
R. Pörtner, B. Frahm, V.C. Hass, P. Lane, A. Munack, Optimierung und Steuerung von Zellkultur-Fed-Batch-Prozessen mittels einer Kollokationsmethode, 2005.
ELSA
 
[33]
2004 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2345 | OA
Evaluation of selected control strategies for fed-batch cultures of a hybridoma cell line
R. Pörtner, J.-O. Schwabe, B. Frahm, Biotechnology and Applied Biochemistry 40 (2004).
ELSA | DOI | Download (ext.)
 
[32]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2343 | OA
Fed-Batch-Kultivierung tierischer Zellen - Eine Herausforderung zur adaptiven, modellbasierten Steuerung
B. Frahm, V.C. Hass, P. Lane, A. Munack, H. Märkl, R. Pörtner, Chemie Ingenieur Technik 75 (2003) 457–460.
ELSA | DOI | Download (ext.)
 
[31]
2003 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2344 | OA
Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis
B. Frahm, P. Lane, H. Märkl, R. Pörtner, Bioprocess and Biosystems Engineering 26 (2003) 1–10.
ELSA | DOI | Download (ext.)
 
[30]
2003 | Dissertation | ELSA-ID: 2393
Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen
B. Frahm, Adaptive, modellgestützte Prozessführung von Suspensionskulturen tierischer Zellen, Books on Demand GmbH, Norderstedt, 2003.
ELSA
 
[29]
2003 | Konferenzband - Beitrag | ELSA-ID: 2435
Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control
B. Frahm, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control, Inst. für Bioprozess- und Analysenmesstechnik , Heiligenstadt, 2003.
ELSA
 
[28]
2003 | Konferenzband - Beitrag | ELSA-ID: 2436
Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells
K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. Hass, Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, ECCE4, Granada, 2003.
ELSA
 
[27]
2003 | Konferenz - Vortrag | ELSA-ID: 2902
Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung
B. Frahm, R. Pörtner, Fed-Batch-Kultivierungen tierischer Zellen – eine Herausforderung an eine modellgestützte, adaptive Steuerung, 2003.
ELSA
 
[26]
2003 | Konferenz - Vortrag | ELSA-ID: 2903
Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung
V.C. Hass, K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, Ein strukturiertes Kompartiment-Modell zur Beschreibung der Kultivierung von Hybridomazellen als Teil einer adaptiven, modellgestützten Prozessführung, 2003.
ELSA
 
[25]
2003 | Konferenz - Vortrag | ELSA-ID: 2905
Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies
B. Frahm, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies, 2003.
ELSA | Dateien verfügbar
 
[24]
2003 | Konferenz - Vortrag | ELSA-ID: 2906
Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung
R. Pörtner, B. Frahm, P. Lane, V.C. Hass, A. Munack, H. Märkl, Fed-Batch-Kultivierung tierischer Zellen – eine Herausforderung für eine adaptive, modellgestützte Steuerung, 2003.
ELSA
 
[23]
2003 | Konferenz - Poster | ELSA-ID: 2964
CO2-off-gas measurement for animal cell culture processes
B. Frahm, R. Pörtner, CO2-off-Gas Measurement for Animal Cell Culture Processes, 2003.
ELSA
 
[22]
2003 | Konferenz - Poster | ELSA-ID: 2965
Flexible fed-batch process control of animal cells
B. Frahm, R. Pörtner, Flexible Fed-Batch Process Control of Animal Cells, 2003.
ELSA
 
[21]
2003 | Konferenz - Poster | ELSA-ID: 2966
Adaptive, Model-based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells
K. Kühn, B. Frahm, R. Pörtner, P. Lane, A. Munack, V.C. Hass, Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Cultivation of Hybridoma Cells, 2003.
ELSA
 
[20]
2003 | Konferenz - Vortrag | ELSA-ID: 7934
Fed-batch-cultivation of animal cells: Model-based, adaptive control in comparison to alternative control strategies
B. Frahm, R. Pörtner, Fed-Batch-Cultivation of Animal Cells: Model-Based, Adaptive Control in Comparison to Alternative Control Strategies, 2003.
ELSA
 
[19]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2340 | OA
Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement
B. Frahm, H.-C. Blank, P. Cornand, W. Oelßner, U. Guth, P. Lane, A. Munack, K. Johannsen, R. Pörtner, Journal of Biotechnology 99 (2002) 133–148.
ELSA | DOI | Download (ext.)
 
[18]
2002 | Zeitschriftenaufsatz (wiss.) | ELSA-ID: 2341 | OA
Adaptive, Model-Based Control by the Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch Cultivation of Hybridoma Cells
B. Frahm, P. Lane, H. Atzert, A. Munack, M. Hoffmann, V.C. Hass, R. Pörtner, Biotechnology Progress 18 (2002) 1095–1103.
ELSA | DOI | Download (ext.)
 
[17]
2002 | Zeitschriftenaufsatz | ELSA-ID: 2342
Reaktor-Abgasmessungen bei Zellkulturen
B. Frahm, R. Pörtner, BIOforum 4 (2002) 179–180.
ELSA
 
[16]
2002 | Konferenzband - Beitrag | ELSA-ID: 2431
Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen
B. Frahm, R. Pörtner, Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen, Kurt-Schwabe-Inst. , Meinsberg , 2002.
ELSA
 
[15]
2002 | Konferenz - Vortrag | ELSA-ID: 2897
Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen
B. Frahm, R. Pörtner, Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen, 2002.
ELSA
 
[14]
2002 | Konferenz - Vortrag | ELSA-ID: 2898
Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells
B. Frahm, R. Pörtner, Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells, 2002.
ELSA
 
[13]
2002 | Konferenz - Vortrag | ELSA-ID: 2899
Adaptive, model-based control by the OLFO-controller for the fed-batch cultivation of animal cells
B. Frahm, R. Pörtner, Adaptive, Model-Based Control by the OLFO-Controller for the Fed-Batch Cultivation of Animal Cells, 2002.
ELSA
 
[12]
2002 | Konferenz - Vortrag | ELSA-ID: 2900
Fed-batch cultivation of animal cells - a challenge for adaptive, model-based control
B. Frahm, B. Müller-Landré, G. Wiggers de Almeida, M. Singer, M. Rausch, P. Lane, A. Munack, V.C. Hass, R. Pörtner, Fed-Batch Cultivation of Animal Cells - a Challenge for Adaptive, Model-Based Control, 2002.
ELSA
 
[11]
2001 | Konferenzband - Beitrag | ELSA-ID: 2427
Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells
B. Frahm, H. Atzert, P. Lane, M. Hoffmann, V.C. Hass, A. Munack, R. Pörtner, Development of an Automated, Adaptive Model-Based Control for the Effective Cultivation of Hybridoma Cells, Springer, Dordrecht, 2001.
ELSA | DOI
 
[10]
2001 | Konferenz - Poster | ELSA-ID: 2429
Model-Based Control of Hybridoma Cell Cultures
V.C. Hass, P. Lane, M. Hoffmann, B. Frahm, J.-O. Schwabe, R. Pörtner, A. Munack, Model-Based Control of Hybridoma Cell Cultures, 2001.
ELSA
 
[9]
2001 | Konferenz - Vortrag | ELSA-ID: 2894
Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen
M. Hoffmann, V.C. Hass, B. Frahm, J.-O. Schwabe, R. Pörtner, P. Lane, A. Munack, Untersuchung verschiedener mathematischer Modelle in Hinblick auf ihre Eignung für die adaptive Prozessführung von Hybridoma Zellkulturen, 2001.
ELSA
 
[8]
2001 | Konferenz - Vortrag | ELSA-ID: 2895
Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik
B. Frahm, R. Pörtner, Arbeitsschwerpunkte TUHH, Bioprozess- und Bioverfahrenstechnik, Arbeitsgruppe Zellkulturtechnik, 2001.
ELSA
 
[7]
2001 | Konferenz - Poster | ELSA-ID: 2960
Adaptive modellgestützte Steuerung von Zellkulturprozessen
B. Frahm, H. Atzert, J.-O. Schwabe, P. Lane, A. Munack, M. Hoffmann, V.C. Hass, R. Pörtner, Adaptive Modellgestützte Steuerung von Zellkulturprozessen, 2001.
ELSA
 
[6]
2001 | Konferenz - Poster | ELSA-ID: 2961
Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities
P. Lane, B. Frahm, H. Atzert, J.-O. Schwabe, M. Hoffmann, V.C. Hass, R. Pörtner, Design of Feeding Strategies for Fed-Batch Cultures of Animal Cells by the Method of Inequalities, 2001.
ELSA
 
[5]
2001 | Konferenz - Poster | ELSA-ID: 2962
Development of an automated, model-based, adaptive control for the effective cultivation of hybridoma cells
B. Frahm, H. Atzert, P. Lane, M. Hoffmann, V.C. Hass, A. Munack, R. Pörtner, Development of an Automated, Model-Based, Adaptive Control for the Effective Cultivation of Hybridoma Cells, 2001.
ELSA
 
[4]
2001 | Konferenzband - Beitrag | ELSA-ID: 2963 | OA
Model-Based Control of Hybridoma Cell Cultures
V.C. Hass, P. Lane, M. Hoffmann, B. Frahm, J.-O. Schwabe, R. Pörtner, A. Munack, Model-Based Control of Hybridoma Cell Cultures, ScienceDirect, Oxford, 2001.
ELSA | DOI | Download (ext.)
 
[3]
2001 | Konferenz - Vortrag | ELSA-ID: 7933
Messung und Simulation des Kohlendioxidausstoßes von Zellkulturprozessen
B. Frahm, R. Pörtner, Messung Und Simulation Des Kohlendioxidausstoßes von Zellkulturprozessen, 2001.
ELSA
 
[2]
2000 | Konferenz - Vortrag | ELSA-ID: 2893
Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren
T. Anderelei, B. Frahm, J. Büchs, Online-Bestimmung der Sauerstofftransferrate (OTR) und der Kohlendioxidtransferrate (CTR) in geschüttelten Bioreaktoren, 2000.
ELSA
 
[1]
2000 | Konferenz - Poster | ELSA-ID: 2959
Modellgestützte Prozessführung für Hybridoma-Kulturen mit Hilfe des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus
M. Hoffmann, B. Frahm, J.-O. Schwabe, P. Lane, R. Pörtner, V.C. Hass, A. Munack, Modellgestützte Prozessführung Für Hybridoma-Kulturen Mit Hilfe Des Open-Loop-Feedback-Optimal (OLFO)- Algorithmus, 2000.
ELSA
 
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