Bioactive peptides in cosmetic formulations: Review of current in vitro and ex vivo evidence

N. van Walraven, R.J. FitzGerald, H.-J. Danneel, M. Amigo-Benavent, Eptides : An International Journal 193 (2025).

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Zeitschriftenaufsatz (wiss.) | Veröffentlicht | Englisch
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Abstract
Bioactive peptides are increasingly employed in cosmetic products and these are generically known as cosmetic peptides. This review aims to provide an update on current information related to commercially available cosmetic peptides, and the in vitro and ex vivo evidence for their potential biological effects. A total of 102 commercially available cosmetic peptides were identified. The majority of these peptides are inspired by molecules already found in the human body, including sequences from extracellular matrix molecules, also known as matrikines. Cosmetic peptides are produced either through chemical synthesis or via biotechnological processes. Their claimed biological activities include signaling to increase collagen and hyaluronic acid production, modulation of pigmentation, maintenance of a healthy skin microbiome, antioxidant activity and cellular defense, immunomodulation, neurotransmitter inhibition, enzyme activity inhibition and trace mineral carriers. The primary structure and current scientific evidence for the bioactivities of these peptides are presented and discussed. The review highlights the diverse methodological approaches used and the outcomes measured in the assessment of cosmetic peptide efficacy. Overall, a large range of cosmetic peptides are commercially available whose efficacy is supported by divergent levels of in vitro and ex vivo data.
Erscheinungsjahr
Zeitschriftentitel
eptides : an international journal
Band
193
Zeitschriftennummer
11
Artikelnummer
171440
ISSN
ELSA-ID

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van Walraven N, FitzGerald RJ, Danneel HJ, Amigo-Benavent M. Bioactive peptides in cosmetic formulations: Review of current in vitro and ex vivo evidence. eptides : an international journal . 2025;193(11). doi:10.1016/j.peptides.2025.171440
van Walraven, N., FitzGerald, R. J., Danneel, H.-J., & Amigo-Benavent, M. (2025). Bioactive peptides in cosmetic formulations: Review of current in vitro and ex vivo evidence. Eptides : An International Journal , 193(11), Article 171440. https://doi.org/10.1016/j.peptides.2025.171440
van Walraven N et al. (2025) Bioactive Peptides in Cosmetic Formulations: Review of Current in Vitro and Ex Vivo Evidence. eptides : an international journal 193.
Walraven, Nathalie van, Richard J. FitzGerald, Hans-Jürgen Danneel, and Miryam Amigo-Benavent. “Bioactive Peptides in Cosmetic Formulations: Review of Current in Vitro and Ex Vivo Evidence.” Eptides : An International Journal 193, no. 11 (2025). https://doi.org/10.1016/j.peptides.2025.171440.
van Walraven, Nathalie, Richard J. FitzGerald, Hans-Jürgen Danneel und Miryam Amigo-Benavent. 2025. Bioactive peptides in cosmetic formulations: Review of current in vitro and ex vivo evidence. eptides : an international journal 193, Nr. 11. doi:10.1016/j.peptides.2025.171440, .
van Walraven, Nathalie ; FitzGerald, Richard J. ; Danneel, Hans-Jürgen ; Amigo-Benavent, Miryam: Bioactive peptides in cosmetic formulations: Review of current in vitro and ex vivo evidence. In: eptides : an international journal Bd. 193. Amsterdam [u.a.], Elsevier BV (2025), Nr. 11
N. van Walraven, R.J. FitzGerald, H.-J. Danneel, M. Amigo-Benavent, Bioactive peptides in cosmetic formulations: Review of current in vitro and ex vivo evidence, Eptides : An International Journal . 193 (2025).
N. van Walraven, R. J. FitzGerald, H.-J. Danneel, and M. Amigo-Benavent, “Bioactive peptides in cosmetic formulations: Review of current in vitro and ex vivo evidence,” eptides : an international journal , vol. 193, no. 11, Art. no. 171440, 2025, doi: 10.1016/j.peptides.2025.171440.
van Walraven, Nathalie, et al. “Bioactive Peptides in Cosmetic Formulations: Review of Current in Vitro and Ex Vivo Evidence.” Eptides : An International Journal , vol. 193, no. 11, 171440, 2025, https://doi.org/10.1016/j.peptides.2025.171440.
Walraven, Nathalie van u. a.: Bioactive peptides in cosmetic formulations: Review of current in vitro and ex vivo evidence, in: eptides : an international journal 193 (2025), H. 11.
van Walraven N, FitzGerald RJ, Danneel HJ, Amigo-Benavent M. Bioactive peptides in cosmetic formulations: Review of current in vitro and ex vivo evidence. eptides : an international journal . 2025;193(11).

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